Publications by authors named "Bei-Yun Zhou"

3 Publications

  • Page 1 of 1

Evaluation of Subjective Sleep Disturbances in Cancer Patients: A Cross-Sectional Study in a Radiotherapy Department.

Front Psychiatry 2021 18;12:648896. Epub 2021 Mar 18.

Department of Radiation Oncology, The First Affiliated Hospital of Xiamen University, Xiamen, China.

The factors associated with sleep disturbances in cancer patients remains unclear. This study aimed to explore the prevalence of sleep disorders and predictors associated with sleep disturbance in cancer patients from a radiotherapy department. Patients with cancers were recruited before the start of radiotherapy from our institution between January 2019 and February 2020. Pittsburgh Sleep Quality Index (PSQI) scale was used to assess sleep quality. Descriptive statistics, Chi-square test, and multivariate logistic regression analysis were used to conduct statistical analysis. A total of 330 eligible patients were included. Of them, 38.3% ( = 127) had the globe PSQI score >7, indicating that they suffered from sleep disorders. Patients with lung cancer (45.2%) were more likely to suffer from sleep disturbance, followed by cervical cancer (43.8%), nasopharyngeal carcinoma (41.7%), esophageal cancer (41.5%), breast cancer (37.7%), and colorectal cancer (30%). With regard to the PSQI components, the mean sleep duration was 8 h, 20.3% ( = 67) of them reported poor subjective sleep quality, 6.1% ( = 20) needed medication to improve sleep, and 53.6% ( = 177) suffered daytime dysfunction. Multivariate logistic regression models showed body mass index (BMI) ≥ 20 kg/m [odds ratio (OR) 0.599, 95% confidence interval (CI) 0.329-0.948, = 0.031] and the receipt of surgery (OR 0.507, 95% CI 0.258-0.996, = 0.048) were the significant favorable predictors for sleep disturbance, while age, gender, marital status, education level, comorbidity, metastasis status, diagnostic status, and cancer type were not significantly associated with sleep disturbance. Approximately 40% of the cancer patients suffer from sleep disturbance before the start of radiotherapy. Patients with BMI ≥ 20 kg/m and receiving surgery are less likely to develop sleep disturbance in comparison with others.
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March 2021

Cloning and Sequencing of Rhizobium huakuii exoA Gene Encoding a Glucosyl-transferase.

Sheng Wu Hua Xue Yu Sheng Wu Wu Li Xue Bao (Shanghai) 1998 ;30(4):319-324

Institute of Plant Physiology, the Chinese Academy of Sciences, Shanghai 200031, China.

From exoR'-11 which could complement two Exo(-) mutants of R. huakuii 107: NA03 and NA10, a 2.0kb BglI fragment was subcloned in pRK415. The resulted plasmid pJB-H701 could restore the Exo(-) phenotype of NA03 and NA10. The complete nucleotide sequence of the fragment was determined, which contains the structural genes of a glucosyl-transferase, as well as the 5'- and 3'- flanking regions. An open reading frame of 984 base pairs was identified as R. huakuii exoA gene. The MW of ExoA, as deduced from the nucleotide sequence, was estimated as 35 kD. Comparison of the nucleotide sequences revealed a high similarity between exoA genes of R. huakuii and R. meliloti. The deduced amino acid sequence of R. huakuii ExoA also showed a high similarity with that of R. meliloti ExoA. Furthermore, the exoA-lacZ transcription fusion gene was constructed and the expression of exoA-lacZ was analyzed.
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January 1998

Sequence Analysis of the exo1 Gene Involved in the Exopolysaccharide Synthesis of Rhizobium huakuii.

Sheng Wu Hua Xue Yu Sheng Wu Wu Li Xue Bao (Shanghai) 1997 ;29(5):481-488

Shanghai Institute of Plant Physiology, the Chinese Academy of Sciences, Shanghai 200032, China.

The 2.6 kb fragment which can complement the Exo(-)Ndv(-)Fix(-) mutants of R. huakuii to Exo(+)Nod(+)Fix(+) was sequenced. The result revealed the presence of an open reading frame exo1, which encodes 340 amino acids. Analysis of the hydrophobicity plot of the putative protein indicated that it was a cytoplasmic protein. Exo1 displayed strong homology to the ExoU protein of R. meliloti, which was a glucosyltransferase. A transcriptional fusion to lacZ using the promoterless vector pMP221 showed that there were two regions with promoter activity in exo1. Pexo1a was identified upstream of exo1, and Pexo1b in the middle of exo1. Pexo1a probably contains the promoter of exo1 gene.
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January 1997