Bei B Zhang

Bei B Zhang

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Bei B Zhang

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A novel series of indazole-/indole-based glucagon receptor antagonists.

Bioorg Med Chem Lett 2015 Oct 8;25(19):4143-7. Epub 2015 Aug 8.

Early Development and Discovery Science, and Preclinical Development, Merck Research Laboratories, 2015 Galloping Hill Rd, Kenilworth, NJ 07033, United States.

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http://dx.doi.org/10.1016/j.bmcl.2015.08.015DOI Listing
October 2015

Bombesin receptor subtype-3 (BRS-3) regulates glucose-stimulated insulin secretion in pancreatic islets across multiple species.

Endocrinology 2011 Nov 30;152(11):4106-15. Epub 2011 Aug 30.

Department of Diabetes and Obesity, Merck Research Laboratories, Rahway, New Jersey 07065, USA.

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https://academic.oup.com/endo/article-lookup/doi/10.1210/en.
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http://dx.doi.org/10.1210/en.2011-1440DOI Listing
November 2011

A model selection approach for expression quantitative trait loci (eQTL) mapping.

Genetics 2011 Feb 29;187(2):611-21. Epub 2010 Nov 29.

Department of Statistics, University of Wisconsin, Madison, Wisconsin 53726, USA.

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http://dx.doi.org/10.1534/genetics.110.122796DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3030500PMC
February 2011

A small-molecule glucokinase activator lowers blood glucose in the sulfonylurea-desensitized rat.

Eur J Pharmacol 2010 Aug 11;640(1-3):250-6. Epub 2010 May 11.

Tsukuba Research Institute, Banyu Pharmaceutical Co., Ltd., 3 Okubo, Tsukuba, Ibaraki 300-2611, Japan.

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http://linkinghub.elsevier.com/retrieve/pii/S001429991000386
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http://dx.doi.org/10.1016/j.ejphar.2010.04.054DOI Listing
August 2010

AMPK: an emerging drug target for diabetes and the metabolic syndrome.

Cell Metab 2009 May;9(5):407-16

Department of Metabolic Disorders, Merck Research Laboratories, Rahway, NJ 07065, USA.

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https://linkinghub.elsevier.com/retrieve/pii/S15504131090009
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http://dx.doi.org/10.1016/j.cmet.2009.03.012DOI Listing
May 2009

Relationship among brain and blood glucose levels and spontaneous and glucoprivic feeding.

J Neurosci 2009 May;29(21):7015-22

Neurology Service, Department of Veterans Affairs New Jersey Health Care System, East Orange, New Jersey 07018, USA.

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http://dx.doi.org/10.1523/JNEUROSCI.0334-09.2009DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2728115PMC
May 2009

Metabolic dysregulation and adipose tissue fibrosis: role of collagen VI.

Mol Cell Biol 2009 Mar 29;29(6):1575-91. Epub 2008 Dec 29.

Department of Cell Biology, Diabetes Research Center, Albert Einstein College of Medicine, Bronx, New York 10461, USA.

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http://mcb.asm.org/cgi/doi/10.1128/MCB.01300-08
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http://dx.doi.org/10.1128/MCB.01300-08DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2648231PMC
March 2009

PANIC-ATTAC: a mouse model for inducible and reversible beta-cell ablation.

Diabetes 2008 Aug 9;57(8):2137-48. Epub 2008 May 9.

Department of Cell Biology, Albert Einstein College of Medicine, Bronx, New York, USA.

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http://dx.doi.org/10.2337/db07-1631DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2494693PMC
August 2008

Malonyl CoenzymeA decarboxylase regulates lipid and glucose metabolism in human skeletal muscle.

Diabetes 2008 Jun 26;57(6):1508-16. Epub 2008 Feb 26.

Department of Molecular Medicine and Surgery, Karolinska University Hospital, Karolinska Institutet, Stockholm, Sweden.

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http://dx.doi.org/10.2337/db07-0583DOI Listing
June 2008

Ventromedial hypothalamic glucokinase is an important mediator of the counterregulatory response to insulin-induced hypoglycemia.

Diabetes 2008 May 21;57(5):1371-9. Epub 2008 Feb 21.

Neurology Service, Department of Veterans Affairs New Jersey Health Care System, East Orange, New Jersey 07018-1095, USA.

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http://diabetes.diabetesjournals.org/cgi/doi/10.2337/db07-17
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http://dx.doi.org/10.2337/db07-1755DOI Listing
May 2008

Cloning and expression of canine glucagon receptor and its use to evaluate glucagon receptor antagonists in vitro and in vivo.

Eur J Pharmacol 2007 Jan 21;555(1):8-16. Epub 2006 Oct 21.

Department of Metabolic Disorder-Molecular Endocrinology, Merck Research Laboratories, Rahway, NJ 07065, USA.

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http://dx.doi.org/10.1016/j.ejphar.2006.10.033DOI Listing
January 2007

A miniaturized cell-based fluorescence resonance energy transfer assay for insulin-receptor activation.

Anal Biochem 2006 Aug 9;355(2):267-77. Epub 2006 Jun 9.

Department of Automated Biotechnology, Merck & Co., Inc., 502 Louise Lane, North Wales, PA 19454, USA.

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http://dx.doi.org/10.1016/j.ab.2006.05.016DOI Listing
August 2006

siRNA-based gene silencing reveals specialized roles of IRS-1/Akt2 and IRS-2/Akt1 in glucose and lipid metabolism in human skeletal muscle.

Cell Metab 2006 Jul;4(1):89-96

Department of Molecular Medicine and Surgery, Karolinska University Hospital, Karolinska Institutet, Stockholm, Sweden.

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http://dx.doi.org/10.1016/j.cmet.2006.04.008DOI Listing
July 2006

Glucokinase is a critical regulator of ventromedial hypothalamic neuronal glucosensing.

Diabetes 2006 Feb;55(2):412-20

Department of Neurology and Neuroscience, New Jersey Medical School, Newark, USA.

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http://dx.doi.org/10.2337/diabetes.55.02.06.db05-1229DOI Listing
February 2006

Therapeutic actions of an insulin receptor activator and a novel peroxisome proliferator-activated receptor gamma agonist in the spontaneously hypertensive obese rat model of metabolic syndrome X.

J Pharmacol Exp Ther 2005 Jul 15;314(1):422-30. Epub 2005 Apr 15.

Department of Nutrition, Case Western Reserve University School of Medicine, Cleveland, OH 44106-4906, USA.

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http://dx.doi.org/10.1124/jpet.104.080606DOI Listing
July 2005

Prevention of obesity in mice by antisense oligonucleotide inhibitors of stearoyl-CoA desaturase-1.

J Clin Invest 2005 Apr 10;115(4):1030-8. Epub 2005 Mar 10.

Metabolic Disorders - Diabetes and Comparative Medicine, Merck Research Laboratories, Rahway, New Jersey 07065, USA.

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http://dx.doi.org/10.1172/JCI23962DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1062893PMC
April 2005

Small-molecule insulin mimetic reduces hyperglycemia and obesity in a nongenetic mouse model of type 2 diabetes.

Endocrinology 2004 Nov 5;145(11):5259-68. Epub 2004 Aug 5.

Medizinische Klinik mit Schwerpunkt Hepatologie, Gastroenterologie, Endokrinologie, und Stoffwechsel Charité-Universitätsmedizin Berlin, Campus Virchow-Klinikum, Augustenburger Platz 1, 13353 Berlin, Germany.

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http://dx.doi.org/10.1210/en.2004-0610DOI Listing
November 2004

Rosiglitazone, an agonist of peroxisome-proliferator-activated receptor gamma (PPARgamma), decreases inhibitory serine phosphorylation of IRS1 in vitro and in vivo.

Biochem J 2004 Jan;377(Pt 2):339-46

Molecular Endocrinology - Diabetes, Merck Research Laboratories, RY80N-C31, P.O. Box 2000, Rahway, NJ 07065, USA.

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http://dx.doi.org/10.1042/BJ20031207DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1223877PMC
January 2004

Mice lacking dipeptidyl peptidase IV are protected against obesity and insulin resistance.

Proc Natl Acad Sci U S A 2003 May 14;100(11):6825-30. Epub 2003 May 14.

Department of Metabolic Disorders and Molecular Endocrinology, Merck Research Laboratories, Rahway, NJ 07065, USA.

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http://dx.doi.org/10.1073/pnas.0631828100DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC164531PMC
May 2003

Glucagon and regulation of glucose metabolism.

Am J Physiol Endocrinol Metab 2003 Apr;284(4):E671-8

Department of Metabolic Disorders and Molecular Endocrinology, Merck Research Laboratory, Rahway, New Jersey 07065, USA.

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http://dx.doi.org/10.1152/ajpendo.00492.2002DOI Listing
April 2003

Somatostatin receptor subtype 5 regulates insulin secretion and glucose homeostasis.

Mol Endocrinol 2003 Jan;17(1):93-106

Department of Molecular Endocrinology, Merck Research Laboratories, Rahway, New Jersey 07065, USA.

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http://dx.doi.org/10.1210/me.2001-0035DOI Listing
January 2003

Hypothalamic insulin signaling is required for inhibition of glucose production.

Nat Med 2002 Dec 11;8(12):1376-82. Epub 2002 Nov 11.

Department of Medicine, Diabetes Research and Training Center, Albert Einstein College of Medicine, Bronx, New York, USA.

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http://dx.doi.org/10.1038/nm1202-798DOI Listing
December 2002

Regulation of insulin signal transduction pathway by a small-molecule insulin receptor activator.

Biochem J 2002 Oct;367(Pt 1):301-6

Department of Molecular Endocrinology, Merck Research Laboratories, PO Box 2000, 126 East Lincoln Avenue, Rahway, NJ 07065, U.S.A.

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http://dx.doi.org/10.1042/BJ20020708DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1222849PMC
October 2002

Decreased insulin receptor (IR) autophosphorylation in fibroblasts from patients with PCOS: effects of serine kinase inhibitors and IR activators.

J Clin Endocrinol Metab 2002 Sep;87(9):4088-93

University of California at San Francisco, Mount Zion Medical Center, San Francisco, California 94143, USA.

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https://academic.oup.com/jcem/article-lookup/doi/10.1210/jc.
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http://dx.doi.org/10.1210/jc.2002-020363DOI Listing
September 2002

Pi 3-kinase and its up- and down-stream modulators as potential targets for the treatment of type II diabetes.

Front Biosci 2002 Apr 1;7:d903-7. Epub 2002 Apr 1.

Metabolic Disorders-Diabetes, Merck Research Laboratories, RY80N-C31, P.O Box 2000, Rahway, NJ 07065, USA.

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April 2002

Detection of glucagon-dependent GTPgammaS binding in high-throughput format.

Anal Biochem 2002 Feb;301(1):156-9

Department of Molecular Endocrinology, Merck Research Laboratories, RY80N-C31, Rahway, New Jersey 07065, USA.

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http://dx.doi.org/10.1006/abio.2001.5483DOI Listing
February 2002

Effect of the insulin mimetic L-783,281 on intracellular Ca2+ and insulin secretion from pancreatic beta-cells.

Diabetes 2002 Feb;51 Suppl 1:S43-9

Department of Chemistry, University of Florida, Gainesville, FL, USA.

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http://dx.doi.org/10.2337/diabetes.51.2007.s43DOI Listing
February 2002

Small molecule insulin mimetics reduce food intake and body weight and prevent development of obesity.

Nat Med 2002 Feb;8(2):179-83

Department of Biomedical Sciences and Cell Biology, University of Cincinnati College of Medicine, Cincinnati, Ohio, USA.

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http://dx.doi.org/10.1038/nm0202-179DOI Listing
February 2002