Publications by authors named "Behrooz Barikbin"

26 Publications

  • Page 1 of 1

The Efficacy of IPL in Periorbital Skin Rejuvenation: An Open-Label Study.

J Lasers Med Sci 2019 1;10(Suppl 1):S64-S67. Epub 2019 Dec 1.

Laser Application in Medical Sciences Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

Intense pulsed light (IPL) is one of the effective methods used to treat the signs of facial aging. However, its efficacy in improving the appearance of periorbital wrinkles has always been evaluated in the context of whole-face rejuvenation and not studied in its own right. Therefore, in this study, we sought to examine the effectiveness and side effects of IPL in periorbital skin rejuvenation. In this uncontrolled, open-label clinical trial, 38 patients referred to the Behrooz professional skin clinic for signs of periorbital skin aging were recruited. The patients underwent three treatment sessions with IPL at one-month intervals and were evaluated for treatment side effects after each session. Six months after the final IPL session, patients were examined to assess the level of symptom improvement. The patients were photographed at each treatment session and on the 6-month follow-up visit. Before and after treatment, the patient images were evaluated by two dermatologists unaffiliated with the study to determine the extent of improvement in the appearance of wrinkles and skin texture. Six months' post-treatment, excellent improvement was observed in 3 patients (9.1%), considerable improvement in 7 patients (21.2%), moderate improvement in 9 patients (27.3%), mild improvement in 9 patients (27.3%), and finally little or no improvement in 5 patients (15.1%). A comparison of improvement scores based on the Fitzpatrick skin phenotype did not show significant differences (P=0.674). Four patients (12.1%) were dissatisfied with the treatment, whilst 17 patients (51.5%) reported moderate to considerable satisfaction with IPL rejuvenation. During facial rejuvenation, IPL can be used to improve periorbital skin aging.
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http://dx.doi.org/10.15171/jlms.2019.S12DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6983864PMC
December 2019

Comparison of the effects of 665 nm low level diode Laser Hat versus and a combination of 665 nm and 808nm low level diode Laser Scanner of hair growth in androgenic alopecia.

J Cosmet Laser Ther 2017 May 17. Epub 2017 May 17.

e Department of Epidemiology and Biostatistics , School of Public Health, Tehran University of Medical Sciences , Tehran , Iran .

Background: This study aimed to evaluate the effectiveness of a combined set of low level diode laser scanner (665 nm and 808nm) on hair growth, and assessment of safety and effectiveness of a new laser scanner on hair growth treatment procedure in androgenic alopecia.

Methods: 90 patients (18 to 70 years) with androgenic alopecia were randomized into three groups. The first group (n=30) received 655 nm red light using laser hat, the second group (n=30) received 655 nm red laser plus 808 nm infrared laser using a laser scanner of hair growth device (with the patent number: 77733) and the third group (n=30) received no laser as the control group.

Results: Patients in laser scanner group had better results and showed a higher increase in terminal hair density compared with laser hat group (mean of 9.61 versus 9.16 per cm). We found significant decrease in terminal hair density from baseline in control group (mean -1.8 per cm, p<0.0001).

Conclusion: Results showed a statistically significant improvement in the laser scanner of the hair growth group compared with laser hat and the control group. The study showed that treatment with new laser devise had a promising result without any observable adverse effects.
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http://dx.doi.org/10.1080/14764172.2017.1326609DOI Listing
May 2017

Blunt Blade Subcision: An Evolution in the Treatment of Atrophic Acne Scars.

Dermatol Surg 2017 Jan;43 Suppl 1:S57-S63

*Laser Application in Medical Sciences Research Center, Shohada-e Tajrish Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran; †Center for Research and Training in Skin Disease and Leprosy, Tehran University of Medical Sciences, Tehran, Iran.

Background: Subcision is the mainstay of atrophic acne scar treatment but the efficacy and safety of the procedure is controversial.

Objective: To improve the efficacy of the subcision procedure, a blunt subcision blade was designed and evaluated.

Methods: Eighteen patients with bilateral atrophic acne scars considered eligible for subcision were enrolled. Before subcision, a tumescent solution was injected subdermally to anesthetize the treatment area and aid the dissection of the dermal-subcutaneous tissue. Patients underwent treatment using the blunt subcision blade, a long metal blade with gradually narrowing edges, and a rounded blunt tip. Early postoperative complications, overall aesthetic improvement and persistent discoloration, or lumpiness were assessed 7 days after subcision and at a 6-month follow-up visit.

Results: Moderate to marked improvement of atrophic scars was observed in 15 cases (83.3%). Mild to moderate tenderness, periorbital ecchymoses, and swelling were reported by some patients, but resolved completely within 1 week after the procedure. No cases of persistent discoloration or lumpiness were observed at the final visit.

Conclusion: The blunt blade subcision procedure is suggested as an effective method for the treatment of atrophic acne scars.
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http://dx.doi.org/10.1097/DSS.0000000000000650DOI Listing
January 2017

Herbal Extracts Induce Dermal Papilla Cell Proliferation of Human Hair Follicles.

Ann Dermatol 2015 Dec 7;27(6):667-75. Epub 2015 Dec 7.

Tehran University of Medical Science, Razi Hospital, Tehran, Iran.

Background: The number of people suffering from balding or hair thinning is increasing, despite the advances in various medical therapies. Therefore, it is highly important to develop new therapies to inhibit balding and increase hair proliferation.

Objective: We investigated the effects of herbal extracts commonly used for improving balding in traditional medicine to identify potential agents for hair proliferation.

Methods: The expression levels of 5α-reductase isoforms (type I and II) were analyzed using quantitative real-time reverse transcription polymerase chain reaction in the human follicular dermal papilla cells (DPCs). The 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenylteterazolium bromide and bromodeoxyuridine tests were used to evaluate the cell proliferation effect of herbal extracts in DPCs. The expression levels of extracellular signal-regulated kinase (ERK), Akt, cyclin D1, cyclin-dependent kinase 4 (Cdk4), B-cell lymphoma (Bcl-2) and Bcl-2-associated X protein (Bax) were measured using western blot analysis.

Results: The 5α-reductase isoform mRNAs and proteins were detected in the cultured DPCs, and the expression level of 5α-R2 in DPCs in the presence of the herbal extracts was gradually decreased. Herbal extracts were found to significantly increase the proliferation of human DPCs at concentrations ranging from 1.5% to 4.5%. These results show that the herbal extracts tested affected the protein expressions of ERK, Akt, cyclin D1, Cdk4, Bcl-2, and Bax in DPCs.

Conclusion: These results suggest that herbal extracts exert positive effects on hair proliferation via ERK, Akt, cyclin D1, and Cdk4 signaling in DPCs; they also suggest that herbal extracts could be a great alternative therapy for increasing hair proliferation.
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http://dx.doi.org/10.5021/ad.2015.27.6.667DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4695417PMC
December 2015

Evaluation of safety and efficacy of 980-nm diode laser-assisted lipolysis versus traditional liposuction for submental rejuvenation: A randomized clinical trial.

J Cosmet Laser Ther 2016 3;18(1):41-5. Epub 2015 Jul 3.

c Department of Imaging , Shohada-e-Tajrish Hospital, Shahid Beheshti University of Medical Sciences , Tehran , Iran.

Background: Submental fat accumulation and skin laxity is a frequent concern of cosmetic patients.

Objective: The aim of this randomized prospective controlled clinical trial was to compare the efficacy and safety of laser-assisted lipolysis and liposuction in the submental rejuvenation.

Material And Methods: Thirty-six female adults were enrolled in this clinical trial and were categorized into two groups: group 1 underwent 980-nm diode laser with the power of 6-8 W and group 2 underwent traditional liposuction. Patients were evaluated with ultrasonography 2 weeks and 2 months after the procedures.

Results: Ultrasonographic evaluation reported the significant reduction of fat thickness in each group compared with the baseline (p value < 0.001). At the 2 weeks and 2 months follow-up visit, fat thickness reduction was significantly higher in the lipolysis group (p value < 0.05). Overall patients' satisfaction in lipolysis group was higher than liposuction with 11 (61%) of lipolysis patients being very satisfied in contrast to 10 (55.5%) of liposuction patients reporting "dissatisfied or neutral" results.

Conclusion: Laser-assisted lipolysis using 980-nm diode is approved to be safe and effective for skin tightening and rejuvenation of the submental area and seems to be a better option than traditional techniques for treatment of this cosmetic problem.
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http://dx.doi.org/10.3109/14764172.2015.1039041DOI Listing
January 2017

Nasal alar necrosis following hyaluronic Acid injection into nasolabial folds: a case report.

World J Plast Surg 2015 Jan;4(1):74-8

School of Medicine, Islamic Azad University, Tehran Branch, Tehran, Iran.

Injection of synthetic fillers for soft tissue augmentation is increasing over the last decade. One of the most common materials used is hyaluronic acid (HA) that is safe and temporary filler for soft tissue augmentation. We present a case of 54-year-old female who experienced vascular occlusion and nasal alar necrosis following HA injection to the nasolabial folds. She suffered from pain, necrosis, infection, and alar loss that finally required a reconstructive surgery for cosmetic appearance of the nose. The case highlights the importance of proper injection technique by an anesthesiologist, as well as the need for immediate recognition and treatment of vascular occlusion.
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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4298868PMC
January 2015

Comparing the Healing Effects of Arnebia euchroma Ointment With Petrolatum on the Ulcers Caused by Fractional CO2 Laser: A Single-Blinded Clinical Trial.

Iran Red Crescent Med J 2014 Oct 5;16(10):e16239. Epub 2014 Oct 5.

Traditional Medicine Clinical Trial Research Center, Shahed University, Tehran, IR Iran.

Background: Arnebia euchroma ointment (AEO) has been used in Iranian traditional medicine for burn wound healing.

Objectives: The aim of this study is to evaluate wound healing efficacy of AEO in burn wounds after fractional Co2 laser.

Patients And Methods: This split-face, single-blinded, single-center clinical study was performed in Shohada-e-Tajrish Hospital, Tehran, Iran. A total of 26 subjects with facial acne scar, who were to receive fractional CO2 laser resurfacing were recruited. After laser procedure, AEO was applied to one side of the face and petrolatum on the other side for wound healing. Digital photographs were taken from acne scar area before resurfacing and on each of the assessment sessions. Three researchers, who were unaware of the applied medications, assessed these digital photographs for erythema, edema, epithelial confluence, crusting/scabbing, and general wound appearance. Subject's irritations such as dryness and itching were evaluated on the second, fifth, and seventh days.

Results: Our study indicated higher epithelial confluence and general wound appearance scores (P = 0.045 for both) and less erythema and edema on fifth day in petrolatum (P = 0.009 and P = 0.034, respectively). The results showed less crusting and erythema (P = 0.016 and P = 0.035, respectively) and higher general wound appearance scores in petrolatum on the second day (P = 0.035 and P = 0.001, respectively). Dryness was the most common subjective complaint in both groups; however, it was more severe in AEO, especially on the second day (P = 0.023).

Conclusions: Despite the healing effects of AEO in burn wounds, petrolatum was more effective than AEO in post-laser wound.
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http://dx.doi.org/10.5812/ircmj.16239DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4270663PMC
October 2014

Effect of Arnebia euchroma ointment on post-laser wound healing in rats.

J Cosmet Laser Ther 2015 Feb 27;17(1):41-5. Epub 2014 Oct 27.

Traditional Medicine Clinical Trial Research Center, Shahed University , Tehran , Iran.

Introduction: Arnebia euchroma ointment has been used in Iranian Traditional Medicine for burn wound healing. The aim of this study is to evaluate wound healing efficacy of A. euchroma ointment on wounds induced after fractional CO2 laser in rats.

Material And Methods: In this study, after anesthetizing two bilateral burn wounds were induced on dorsal skin of the rat using fractional ablative CO2 laser. After applying laser, A. euchroma ointment, petrolatum, and silver sulfadiazine cream were used topically on wounds twice daily for 10 days. Digital photographs were captured from the wound surfaces every day. At the end of the study, two blinded dermatologists observed the photograph of 3rd, 5th, 7th, and 9th days after laser injury and assessed erythema, crusting/scabbing, epithelial confluence, and general wound appearance to determine the efficacy of wound healing. These wound-healing parameters were assessed using the 5-point scales.

Results: This study showed significantly less erythema and crusting (P = 0.024 and P = 0.004, respectively) on 9th day and higher epithelial confluence and general wound appearance scores on 7th (P = 0.037 and p = 0.016, respectively) and 9th days (P = 0.008 and P = 0.016, respectively) in A. euchroma ointment compared with other groups.

Conclusion: This study showed A. euchroma ointment has good healing effects on post-laser wounds in rats.
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http://dx.doi.org/10.3109/14764172.2014.968583DOI Listing
February 2015

Multifocal epithelial hyperplasia: report of 3 cases.

Dermatol Online J 2014 Aug 17;20(8). Epub 2014 Aug 17.

Shahid Beheshti University of Medical Sciences.

Multifocal epithelial hyperplasia (MEH) is a rare disorder characterized by multiple painless discrete and soft flattened papules on the oral mucosa. It is caused by human papilloma virus 13 and 32. The frequency of this disease varies widely from one geographic region to another. Generally it is very rare in Asia. Herein we report 3 Iranian cases with oral lesions, which showed clinical and histopathological characteristics of MEH disease. Two of them were siblings and HPV13 was detected in one of the patients.
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August 2014

Low-power fractional CO₂ laser versus low-fluence Q-switch 1,064 nm Nd:YAG laser for treatment of melasma: a randomized, controlled, split-face study.

Am J Clin Dermatol 2014 Aug;15(4):357-63

Laser Application in Medical Sciences Research Center, Shahid Beheshti University of Medical Sciences, Tajrish Sq, PO Box 1989934148, Tehran, Iran.

Background: Various laser treatments are currently available for melasma but their use remains challenging because of potential side effects.

Objective: The aim of this randomized controlled study was to compare the efficacy and safety of low-fluence Q-switch 1,064 nm Nd:YAG and low-power fractional CO2 laser using a split-face design.

Materials And Methods: A total of 40 female patients with symmetric melasma were enrolled to the study and each side of their face was randomly allocated to either low-fluence Q-switch 1,064 nm Nd:YAG or low-power fractional CO2 laser. They were treated every 3 weeks for five consecutive sessions and followed for 2 months after the last treatment session. Response to treatment was assessed using the Melanin Index (MI) score, modified Melasma Area and Severity Index (mMASI) score, and a subjective self-assessment method.

Results: At the 2-month follow-up visit, both sides of the face had statistically significant reductions in the MI and mMASI scores compared with the first visit (p < 0.001). The differences between the mean MI and mMASI scores at baseline and at 2-month follow-up were compared between the two treatments and results showed that the reduction of MI and mMASI score in the fractional CO2 laser-treated side was significantly more than on the Q-switch 1,064 nm Nd:YAG laser-treated side (p < 0.001). There were no significant adverse effects with either of the laser treatments.

Conclusion: The present study shows that low-power fractional CO2 laser is safe and effective and can be considered as a valuable approach in the treatment of melasma.
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http://dx.doi.org/10.1007/s40257-014-0080-xDOI Listing
August 2014

Lichen planus of the uterine cervix: a rare manifestation of mucocutaneous lichen planus.

Indian J Dermatol Venereol Leprol 2014 May-Jun;80(3):264-5

Skin Research Center, Shahid Beheshti University of Medical Sciences, Shohada-e Tajrish Hospital, Tehran, Iran.

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http://dx.doi.org/10.4103/0378-6323.132262DOI Listing
December 2014

Treatment of multifocal epithelial hyperplasia with imiquimod.

Indian J Dermatol Venereol Leprol 2014 Mar-Apr;80(2):175-7

Department of Dermatology, Skin Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

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http://dx.doi.org/10.4103/0378-6323.129415DOI Listing
November 2014

Ulcerative nodule on a chronic discoid lupus erythematosus lesion.

Indian J Dermatol 2013 Sep;58(5):412

Skin Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

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http://dx.doi.org/10.4103/0019-5154.117374DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3778831PMC
September 2013

Combination of herbal extracts and platelet-rich plasma induced dermal papilla cell proliferation: involvement of ERK and Akt pathways.

J Cosmet Dermatol 2013 Jun;12(2):116-22

Food and Drug Control Laboratory and Research Center, Tehran, Iran.

Background And Aims: Recently, platelet-rich plasma (PRP) has attracted attention in various medical fields, including plastic surgery, treatment for problematic wounds, and dermatology. Specifically, PRP has been tested during hair transplantation to reduce swelling and pain and to increase hair density. We examined the effects of PRP and herbal extracts combination in order to identify potential stimulants of hair growth.

Methods: PRP was prepared using the double-spin method and applied to dermal papilla cells (DPCs). MTT viability test and BrdU cell proliferation assay were used to study the effect of herbal extracts and PRP on proliferation of DPCs. To understand the mechanisms of herbal extracts and PRP involved in the regulation of hair growth, we evaluated signaling pathways and measured the expressions of ERK and Akt, by Western blot.

Results: Combination of herbal extracts and PRP was found to induce significant proliferation of human DPCs at concentrations ranging from 1.5% to 4.5%. The present study shows that herbal extracts and PRP affect the expressions of extracellular signal-regulated kinase (ERK) and Akt in DPCs.

Conclusion: In this study, we have shown that combination of herbal extracts and PRP plays an active role in promoting the proliferation of human dermal papilla (DP) cells via the regulation of ERK and Akt proteins, and this may be applicable to the future development of herbal extracts and PRP combination therapeutics to enhance hair growth.
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http://dx.doi.org/10.1111/jocd.12033DOI Listing
June 2013

Focal high-concentration trichloroacetic acid peeling for treatment of atrophic facial chickenpox scar: an open-label study.

Dermatol Surg 2012 Oct 18;38(10):1662-7. Epub 2012 Sep 18.

Skin Research Center, Shohada-e Tajrish Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

Background: Despite their prevalence, there is a paucity of information in the medical literature on the treatment of atrophic chickenpox scars.

Objective: To evaluate the efficacy and safety of using the chemical reconstruction of skin scar technique for the treatment of atrophic facial chickenpox scars.

Methods And Materials: One hundred patients (mean age 23 years; Fitzpatrick skin types II-IV) were treated with focal chemical peeling with 70% trichloroacetic acid (TCA) for a maximum of six sessions. Improvement rate, frequency of adverse events and patient satisfaction were assessed.

Results: Five hundred thirty-three peeling sessions in 100 consecutive patients were performed. Final assessment at 12-week follow-up visit after the last treatment revealed improvement in 95% of patients: mild improvement in 12 cases, moderate improvement in 42 cases, and marked improvement in 41 cases. The appearance of scars did not change in five patients. Seventy-nine patients expressed moderate to high satisfaction with the results. Post-treatment side effects were mild and transient, resolving gradually within the study period.

Conclusion: Focal peeling with high-concentration TCA appears to be a safe and effective alternative in the treatment of atrophic facial chickenpox scars.
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http://dx.doi.org/10.1111/j.1524-4725.2012.02541.xDOI Listing
October 2012

A case of sarcoidosis mimicking Wegener's granulomatosis.

Int J Dermatol 2013 Oct 22;52(10):1288-90. Epub 2012 May 22.

Tehran University of Medical Sciences, Razi Hospital, Tehran, Iran Skin Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

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http://dx.doi.org/10.1111/j.1365-4632.2011.05137.xDOI Listing
October 2013

Uric Acid: a new antioxidant in patients with pemphigus vulgaris.

Indian J Dermatol 2011 May;56(3):278-81

Skin Research Center, Shohada-e-Tajrish Hospital, Shahid Beheshti Medical University, Tehran, Iran.

Background: Increased reactive oxygen species (ROS) and lipid peroxidation are seen in many dermatologic disorders, for example, atopic dermatitis, psoriasis, vitiligo, acne vulgaris, pemphigus vulgaris (PV), lichen planus, and alopecia areata. ROS has an important role in the inflammation process. In PV, increased production of ROS leads to decline of antioxidants in plasma and red blood cells which results in oxidative stress. We aimed to evaluate the level of these antioxidants in PV patients and compare it to the controls.

Materials And Methods: Among patients attending the dermatology clinics, 30 patients with PV, who had never been on treatment, were enrolled to the study. The control group consisted of 30 age- and sex-matched healthy non-smoker individuals. Venous blood was collected from the subjects for the evaluation of plasma levels of glutathione peroxidase, vitamin C, selenium, bilirubin, and uric acid.

Results: Age mean and standard deviation of the patients (40.83, 12.74) was comparable to the controls (41.96, 13.08). Mean level of uric acid was significantly lower in PV patients compared to the controls (P = 0.006). Other antioxidants were not different between the two groups. Uric acid of the patients with mucosal involvement was significantly lower than patients with mucocutaneous involvement (P = 0.049).

Limitations: The blood level of other antioxidants (e.g. malondialdehyde) was not evaluated.

Conclusions: Uric acid as an antioxidant in our study had similar changes to previous studies in the field of other diseases but selenium, bilirubin, and glutathione peroxidase did not differ between patients and controls.
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http://dx.doi.org/10.4103/0019-5154.82480DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3132903PMC
May 2011

Darier disease associated with HIV infection: a case report.

HIV Clin Trials 2011 Jan-Feb;12(1):48-53

Skin Research Center, Mazandaran University of Medical Sciences, Sari, Iran.

AIDS is characterized with immune dysregulation and depletion of CD4+ T cells and increased vulnerability to different pathological conditions, including many dermatoses. The present report describes features of Darier disease (DD) in an HIV-positive patient. The subject of this report was a 45-year old Ghanaian man referred to the dermatology unit of the Iranian Red Crescent Society in Accra, Ghana. He presented with numerous follicular keratotic red-brown papules on the scalp, face, retroauricular regions, ears, sternum, upper trunk, hands, axilla, and inguinal regions. The lesions first appeared on the dorsal surface of the hands and face and subsequently appeared on the other parts of the body including the outline of the scalp. This is the first report of DD in the setting of HIV infection. Significant features of this case associated with HIV in comparison with non-HIV cases are negative family history of DD, late onset, and wide distribution of the disease without abnormality on the nails and mucous membranes beginning a few years after involvement with HIV virus.
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http://dx.doi.org/10.1310/hct1201-48DOI Listing
April 2011

Pimecrolimus versus placebo in genital aphthous ulcers of Behcet's disease: a randomized double-blind controlled trial.

Int J Rheum Dis 2010 Aug;13(3):253-8

Behçet's Disease Unit, Rheumatology Research Center, Kargar Avenue, Tehran 14114, Iran.

Background: Genital aphthous ulcers of Behcet's disease (BD) are painful and usually resistant to local treatments. Pimecrolimus is an ascomycin macrolactam, used in inflammatory skin diseases.

Objective: To discover if pimecrolimus can accelerate the healing of BD genital aphthous ulcers.

Methods: Ninety patients with genital aphthous ulcers were enrolled. Only patients treated with colchicine alone were selected. All patients signed a written consent form. Patients were randomly assigned to pimecrolimus or placebo cream, applied twice daily for 1 week. The primary outcome was the healing period. Up to 7 days, it was considered as a positive result. Results were compared by chi-square test. The mean healing time was compared by analysis of variance. Analyses were done both by the 'intention-to-treat' and 'treatment-completed' methods.

Results: Both groups were similar at the entry (gender, age, ulcer size, pain intensity and treatment delay). By intention-to-treat analysis, in the pimecrolimus group, 18 patients had positive and 27 negative results. In the control group, four had positive and 41 negative results. The difference was significant (chi(2) = 10.167, P = 0.001). By treatment-completed analysis, with pimecrolimus, 18 patients had positive and 22 negative results. With placebo, four had positive, and 41 negative results. The difference was significant (chi(2) = 12.574, P = 0.0004). Comparison of mean healing time in the pimecrolimus versus placebo group, demonstrated a significant acceleration both in intention-to-treat analysis (10.7 vs. 20.7 days, F = 17.466, P < 0.0001) and treatment-completed analysis (8.3 vs. 20.7 days, F = 29.289, P < 0.0001).

Conclusion: Pimecrolimus is safe and efficient in the treatment of BD genital ulcers, by accelerating the healing process.
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http://dx.doi.org/10.1111/j.1756-185X.2010.01531.xDOI Listing
August 2010

Solitary cutaneous leiomyoma in an infant.

Pediatr Dermatol 2009 Sep-Oct;26(5):621-3

Skin Research Center, Shohada-e Tajrish Hospital, Shahid Beheshti University, Tehran, Iran.

This report describes a case of leiomyoma of the ankle occurring at an unusual age. A 5-month-old girl presented with an asymptomatic nodule on her left ankle.
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http://dx.doi.org/10.1111/j.1525-1470.2009.01000.xDOI Listing
January 2010

An unusual case of adult disseminated cutaneous Langerhans cell histiocytosis.

Dermatol Online J 2006 Oct 31;12(6):13. Epub 2006 Oct 31.

Skin research center and department of dermatology, Shohada-e-tajrish hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

Langerhans cell histiocytosis (LCH) represents a group of rare histiocytic syndromes characterized by tissue infiltration with dendritic cells. The management of LCH is difficult because these disorders respond inconsistently to immunosuppressive and chemotherapeutic strategies. We describe a refractory and relapsing case of skin and nail limited LCH in a 27-year-old man. He presented with a 7-year history of an erythematous papular eruption of the scalp, ears, face, trunk, axillae, groins, fingernails, feet, and toenails. Diagnosis of LCH was made based on skin histopathology and immunohistochemical staining. Histological studies of biopsy specimens revealed a dense infiltrate of histiocytic mononuclear cells beneath the epidermis; these cells reacted strongly with anti-S-100 antibodies. In addition, CD1a was positive in most of the infiltrating cells. Extensive investigations failed to detect systemic involvement. The patient's cutaneous eruption did not respond to various therapeutic interventions, including phototherapy with oral psoralen with long-wave UV radiation in the A range (PUVA) and cyclosporine. Marked but temporary clinical improvement was achieved with thalidomide, etoposide with systemic steroid, and total body electron beam radiotherapy. Now the patient is on maintenance therapy with thalidomide and is under acceptable control.
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October 2006

A case of factitious subcutaneous emphysema.

Dermatol Online J 2006 May 30;12(4). Epub 2006 May 30.

Department of Dermatology, Tehran University of Medical Sciences, Razi Hospital, Tehran, Iran.

A 13-year-old girl presented with a 2-month history of recurrent soft tissue swelling of her right upper extremity. Dermatological examination revealed soft tissue crepitation and a small ulcer on the dorsum of her right hand. After several investigations including radiographic and systemic blood tests the diagnosis of factitious subcutaneous emphysema was made and the patient was referred to psychiatry for proper management.
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May 2006

Bilateral cutaneous leishmaniasis of upper eyelids: a case report.

Dermatol Online J 2006 Jan 27;12(1):20. Epub 2006 Jan 27.

Department of Ophthalmology, Farabi Hospital, Tehran University of Medical Sciences.

An 11-year-old girl presented with a 6-month history of bilateral upper eyelid erythema, induration, and blepharitis resistant to conventional antibiotic therapy. The lesions gradually progressed to symmetrical ulcerative nodules within 3 months. Cutaneous smear and biopsy revealed numerous amastigotes in macrophage cells. Therapy with systemic pentavalent antimonial resulted in successful healing of lesions. We conclude that cutaneous leishmaniasis must be kept in mind in the differential diagnosis of bilateral chronic eyelid swelling in endemic regions of the world.
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January 2006

Methotrexate-induced acral erythema with bullous reaction.

Dermatol Online J 2003 Feb;9(1):14

Dermatology Department of Tehran University of Medical Sciences, Iran.

Chemotherapy-induced acral erythema (CIAE), a toxic reaction to a number of different chomotherapeutic agents, causes a symmetrical, painful erythema of both the palms and soles which is self-limiting. The association of this syndrome with methotrexate is unusual; only nine cases have been reported in the literature. We describe the tenth case of this syndrome associated with methotrexate, which is also the third case of the bullous variant of methotrexate-induced acral erythema. Our case is unusual in that the acral erythema was present only on the soles of the feet and in that it was associated with the presence of diffuse maculopapular lesions over the legs and trunk.
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February 2003

Atypical crusted scabies in an Iranian man.

Dermatol Online J 2002 Oct;8(2):17

Dermatology Department, Tehran University of Medical Sciences, Iran.

Crusted scabies has been defined as a scabies-induced psoriasiform dermatosis on the hands and feet with dystrophy of the nails and an erythematous scaling eruption that may be generalized. This case report demonstrates a patient who presented with widespread psoriasiform plaques that were teeming with scabies mites and eggs, but who had absence of nail and palmar involvement. While patients with crusted scabies may have nail dystrophy and involvement of the palms, this involvement is not necessary.
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October 2002