Publications by authors named "Bastiaan T Heijmans"

100Publications

Repeat UVA exposure of human skin fibroblasts induces both a transitionary and recovery DNA methylation response.

Epigenomics 2020 Apr 9;12(7):563-573. Epub 2020 Jun 9.

Molecular Epidemiology, Department of Biomedical Data Sciences, Leiden University Medical Center, Leiden, The Netherlands.

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http://dx.doi.org/10.2217/epi-2019-0251DOI Listing
April 2020

The tissue-specific aspect of genome-wide DNA methylation in newborn and placental tissues: implications for epigenetic epidemiologic studies.

J Dev Orig Health Dis 2020 Apr 24:1-11. Epub 2020 Apr 24.

Department of Obstetrics and Gynaecology, Erasmus MC, University Medical Centre Rotterdam, Postbus 2040, 3000 CARotterdam, The Netherlands.

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http://dx.doi.org/10.1017/S2040174420000136DOI Listing
April 2020

Genome-wide analysis of constitutional DNA methylation in familial melanoma.

Clin Epigenetics 2020 Mar 6;12(1):43. Epub 2020 Mar 6.

Department of Dermatology, Leiden University Medical Center, Leiden, PO Box 9600, 2300 RC, Leiden, The Netherlands.

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http://dx.doi.org/10.1186/s13148-020-00831-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7060565PMC
March 2020

Reply to 'Chinese famine and the diabetes mellitus epidemic'.

Nat Rev Endocrinol 2020 02;16(2):123-124

Department of Epidemiology, Mailman School of Public Health, Columbia University, New York, NY, USA.

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http://dx.doi.org/10.1038/s41574-019-0301-8DOI Listing
February 2020

Reply to 'Early-life exposure to the Chinese Famine and subsequent T2DM'.

Nat Rev Endocrinol 2020 02;16(2):125-126

Department of Epidemiology, Mailman School of Public Health, Columbia University, New York, NY, USA.

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http://dx.doi.org/10.1038/s41574-019-0302-7DOI Listing
February 2020

: The win ongitudinal nvestigation of tal Discordance.

Twin Res Hum Genet 2019 12 25;22(6):617-622. Epub 2019 Jul 25.

Molecular Epidemiology, Department of Biomedical Data Sciences, Leiden University Medical Center, Leiden, The Netherlands.

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http://dx.doi.org/10.1017/thg.2019.38DOI Listing
December 2019

Human monocyte-to-macrophage differentiation involves highly localized gain and loss of DNA methylation at transcription factor binding sites.

Epigenetics Chromatin 2019 06 6;12(1):34. Epub 2019 Jun 6.

Department of Medical Biochemistry, Amsterdam Cardiovascular Sciences, Meibergdreef 9, Amsterdam UMC, University of Amsterdam, Amsterdam, The Netherlands.

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http://dx.doi.org/10.1186/s13072-019-0279-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6551876PMC
June 2019

The effect of the Chinese Famine on type 2 diabetes mellitus epidemics.

Nat Rev Endocrinol 2019 06;15(6):313-314

Department of Epidemiology, Mailman School of Public Health, Columbia University, New York, NY, USA.

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http://www.nature.com/articles/s41574-019-0195-5
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http://dx.doi.org/10.1038/s41574-019-0195-5DOI Listing
June 2019

Selective Survival of Embryos Can Explain DNA Methylation Signatures of Adverse Prenatal Environments.

Cell Rep 2018 12;25(10):2660-2667.e4

Edward Grey Institute, Department of Zoology, University of Oxford, South Parks Road, Oxford OX1 3PS, UK; Department of Biology, University of Lund, Sölvegatan 37, 22362 Lund, Sweden.

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https://linkinghub.elsevier.com/retrieve/pii/S22111247183176
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http://dx.doi.org/10.1016/j.celrep.2018.11.023DOI Listing
December 2018

Association of maternal prenatal smoking GFI1-locus and cardio-metabolic phenotypes in 18,212 adults.

EBioMedicine 2018 Dec 13;38:206-216. Epub 2018 Nov 13.

Center for Life Course Health Research, University of Oulu, Oulu, Finland; Biocenter Oulu, University of Oulu, Oulu, Finland; Medical Research Centre (MRC) Oulu, Oulu University Hospital, University of Oulu, Oulu, Finland. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S23523964183048
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http://dx.doi.org/10.1016/j.ebiom.2018.10.066DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6306313PMC
December 2018

Genome-wide analysis of DNA methylation in buccal cells: a study of monozygotic twins and mQTLs.

Epigenetics Chromatin 2018 09 25;11(1):54. Epub 2018 Sep 25.

Department of Biological Psychology, Amsterdam Public Health Research Institute, Vrije Universiteit Amsterdam, Van Der Boechorststraat 1, 1081BT, Amsterdam, The Netherlands.

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http://dx.doi.org/10.1186/s13072-018-0225-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6156977PMC
September 2018

Age-related DNA methylation changes are tissue-specific with ELOVL2 promoter methylation as exception.

Epigenetics Chromatin 2018 05 30;11(1):25. Epub 2018 May 30.

Molecular Epidemiology, Department of Biomedical Data Sciences, Leiden University Medical Center, Einthovenweg 20, 2333 ZC, Leiden, The Netherlands.

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http://dx.doi.org/10.1186/s13072-018-0191-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5975493PMC
May 2018

Visit-to-visit lipid variability: Clinical significance, effects of lipid-lowering treatment, and (pharmaco) genetics.

J Clin Lipidol 2018 Mar - Apr;12(2):266-276.e3. Epub 2018 Jan 11.

Department of Cardiology, Leiden University Medical Center, Leiden, The Netherlands; Section of Gerontology and Geriatrics, Department of Internal Medicine, LUMC, Leiden, The Netherlands.

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http://dx.doi.org/10.1016/j.jacl.2018.01.001DOI Listing
September 2019

omicsPrint: detection of data linkage errors in multiple omics studies.

Bioinformatics 2018 06;34(12):2142-2143

Molecular Epidemiology, Department of Medical Statistics and Bioinformatics, Leiden University Medical Center, ZC Leiden, The Netherlands.

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https://academic.oup.com/bioinformatics/article/34/12/2142/4
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http://dx.doi.org/10.1093/bioinformatics/bty062DOI Listing
June 2018

DNA methylation as a mediator of the association between prenatal adversity and risk factors for metabolic disease in adulthood.

Sci Adv 2018 01 31;4(1):eaao4364. Epub 2018 Jan 31.

Molecular Epidemiology, Department of Biomedical Data Sciences, Leiden University Medical Center, 2300 RC Leiden, Netherlands.

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http://dx.doi.org/10.1126/sciadv.aao4364DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5792223PMC
January 2018

IgG glycosylation and DNA methylation are interconnected with smoking.

Biochim Biophys Acta Gen Subj 2018 Mar 18;1862(3):637-648. Epub 2017 Oct 18.

Research Unit Molecular Epidemiology, Institute of Epidemiology 2, Helmholtz Zentrum München - German Research Center for Environmental Health, Neuherberg, Germany; Institute of Epidemiology 2, Helmholtz Zentrum München - German Research Center for Environmental Health, Neuherberg, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.bbagen.2017.10.012DOI Listing
March 2018

Handling blood cell composition in epigenetic studies on ageing.

Int J Epidemiol 2017 10;46(5):1717-1718

Department of Public Health.

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http://dx.doi.org/10.1093/ije/dyx083DOI Listing
October 2017

Controlling bias and inflation in epigenome- and transcriptome-wide association studies using the empirical null distribution.

Genome Biol 2017 01 27;18(1):19. Epub 2017 Jan 27.

Molecular Epidemiology section, Department of Medical Statistics and Bioinformatics, Leiden University Medical Center, Leiden, the Netherlands.

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http://dx.doi.org/10.1186/s13059-016-1131-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5273857PMC
January 2017

Epigenome-wide association study of body mass index, and the adverse outcomes of adiposity.

Authors:
Simone Wahl Alexander Drong Benjamin Lehne Marie Loh William R Scott Sonja Kunze Pei-Chien Tsai Janina S Ried Weihua Zhang Youwen Yang Sili Tan Giovanni Fiorito Lude Franke Simonetta Guarrera Silva Kasela Jennifer Kriebel Rebecca C Richmond Marco Adamo Uzma Afzal Mika Ala-Korpela Benedetta Albetti Ole Ammerpohl Jane F Apperley Marian Beekman Pier Alberto Bertazzi S Lucas Black Christine Blancher Marc-Jan Bonder Mario Brosch Maren Carstensen-Kirberg Anton J M de Craen Simon de Lusignan Abbas Dehghan Mohamed Elkalaawy Krista Fischer Oscar H Franco Tom R Gaunt Jochen Hampe Majid Hashemi Aaron Isaacs Andrew Jenkinson Sujeet Jha Norihiro Kato Vittorio Krogh Michael Laffan Christa Meisinger Thomas Meitinger Zuan Yu Mok Valeria Motta Hong Kiat Ng Zacharoula Nikolakopoulou Georgios Nteliopoulos Salvatore Panico Natalia Pervjakova Holger Prokisch Wolfgang Rathmann Michael Roden Federica Rota Michelle Ann Rozario Johanna K Sandling Clemens Schafmayer Katharina Schramm Reiner Siebert P Eline Slagboom Pasi Soininen Lisette Stolk Konstantin Strauch E-Shyong Tai Letizia Tarantini Barbara Thorand Ettje F Tigchelaar Rosario Tumino Andre G Uitterlinden Cornelia van Duijn Joyce B J van Meurs Paolo Vineis Ananda Rajitha Wickremasinghe Cisca Wijmenga Tsun-Po Yang Wei Yuan Alexandra Zhernakova Rachel L Batterham George Davey Smith Panos Deloukas Bastiaan T Heijmans Christian Herder Albert Hofman Cecilia M Lindgren Lili Milani Pim van der Harst Annette Peters Thomas Illig Caroline L Relton Melanie Waldenberger Marjo-Riitta Järvelin Valentina Bollati Richie Soong Tim D Spector James Scott Mark I McCarthy Paul Elliott Jordana T Bell Giuseppe Matullo Christian Gieger Jaspal S Kooner Harald Grallert John C Chambers

Nature 2017 01 21;541(7635):81-86. Epub 2016 Dec 21.

Department of Epidemiology and Biostatistics, MRC-PHE Centre for Environment and Health, School of Public Health, Imperial College London, London W2 1PG, UK.

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http://dx.doi.org/10.1038/nature20784DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5570525PMC
January 2017

Epigenetic drift in the aging genome: a ten-year follow-up in an elderly twin cohort.

Int J Epidemiol 2016 08 6;45(4):1146-1158. Epub 2016 Aug 6.

Epidemiology, Biostatistics and Biodemography, Department of Public Health, University of Southern Denmark, Odense C, Denmark.

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http://dx.doi.org/10.1093/ije/dyw132DOI Listing
August 2016

The multifaceted interplay between lipids and epigenetics.

Curr Opin Lipidol 2016 06;27(3):288-94

aMolecular Epidemiology section bDepartment of Cardiology, Leiden University Medical Center, Leiden, The Netherlands.

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http://dx.doi.org/10.1097/MOL.0000000000000301DOI Listing
June 2016

Epigenome-Wide Association Study of Aggressive Behavior.

Twin Res Hum Genet 2015 Dec 28;18(6):686-98. Epub 2015 Oct 28.

Department of Biological Psychology,VU Amsterdam,Amsterdam,The Netherlands.

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http://dx.doi.org/10.1017/thg.2015.74DOI Listing
December 2015

DNA Methylation Landscapes of Human Fetal Development.

PLoS Genet 2015 Oct 22;11(10):e1005583. Epub 2015 Oct 22.

Department of Anatomy and Embryology, Leiden University Medical Center, Leiden, The Netherlands; Department for Reproductive Medicine, Ghent University Hospital, Ghent, Belgium.

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http://dx.doi.org/10.1371/journal.pgen.1005583DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4619663PMC
October 2015

Design, measurement and processing of region-specific DNA methylation assays: the mass spectrometry-based method EpiTYPER.

Front Genet 2015 17;6:287. Epub 2015 Sep 17.

Molecular Epidemiology, Department of Medical Statistics and Bioinformatics, Leiden University Medical Center Leiden, Netherlands.

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http://dx.doi.org/10.3389/fgene.2015.00287DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4585020PMC
October 2015

Early gestation as the critical time-window for changes in the prenatal environment to affect the adult human blood methylome.

Int J Epidemiol 2015 Aug 5;44(4):1211-23. Epub 2015 May 5.

Molecular Epidemiology, Leiden University Medical Center, Leiden, The Netherlands, Department of Epidemiology, Mailman School of Public Health, Columbia University, New York, New York USA

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http://dx.doi.org/10.1093/ije/dyv043DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4588866PMC
August 2015

LDL cholesterol still a problem in old age? A Mendelian randomization study.

Int J Epidemiol 2015 Apr 7;44(2):604-12. Epub 2015 Apr 7.

Department of Gerontology and Geriatrics, Leiden University Medical Center, Leiden, The Netherlands, Netherlands Consortium for Healthy Ageing, Leiden, The Netherlands, Department of Molecular Epidemiology, Leiden University Medical Center, Leiden, The Netherlands, Department of Epidemiology, Erasmus University Medical Center, Rotterdam, The Netherlands, Department of Cardiology, Leiden University Medical Center, Leiden, The Netherlands, Leyden Academy of Vitality and Ageing, Leiden, The Netherlands, Faculty of Health and Medical Sciences, Department of Public Health, University of Copenhagen, Copenhagen, Denmark, Durrer Center for Cardiogenetic Research, Amsterdam, The Netherlands and Interuniversity Cardiology Institute of the Netherlands, Utrecht, The Netherlands Department of Gerontology and Geriatrics, Leiden University Medical Center, Leiden, The Netherlands, Netherlands Consortium for Healthy Ageing, Leiden, The Netherlands, Department of Molecular Epidemiology, Leiden University Medical Center, Leiden, The Netherlands, Department of Epidemiology, Erasmus University Medical Center, Rotterdam, The Netherlands, Department of Cardiology, Leiden University Medical Center, Leiden, The Netherlands, Leyden Academy of Vitality and Ageing, Leiden, The Netherlands, Faculty of Health and Medical Sciences, Department of Public Health, University of Copenhagen, Copenhagen, Denmark, Durrer Center for Cardiogenetic Research, Amsterdam, The Netherlands and Interuniversity Cardiology Institute of the Netherlands, Utrecht, The Netherlands Department of Gerontology and Geriatrics, Leiden University Medical Center, Leiden, The Netherlands, Netherlands Consortium for Healthy Ageing, Leiden, The Netherlands, Department of Molecular Epidemiology, Leiden University Medical Center, Leiden, The Netherlands, Department of Epidemiology, Erasmus University Medical Center, Rotterdam, The Netherlands, Department of Cardiology, Leiden University Medical Center, Leiden, The Netherlands, Leyd

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http://dx.doi.org/10.1093/ije/dyv031DOI Listing
April 2015

Epigenetic signature of birth weight discordance in adult twins.

BMC Genomics 2014 Dec 4;15:1062. Epub 2014 Dec 4.

Epidemiology, Biostatistics and Biodemography, Institute of Public Health, University of Southern Denmark, J, B, Winsløws Vej 9B, DK-5000 Odense C, Denmark.

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http://dx.doi.org/10.1186/1471-2164-15-1062DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4302120PMC
December 2014

An alternative approach to multiple testing for methylation QTL mapping reduces the proportion of falsely identified CpGs.

Bioinformatics 2015 Feb 4;31(3):340-5. Epub 2014 Oct 4.

Department of Molecular Epidemiology, Department of Medical Statistics and Bioinformatics, Leiden University Medical Center, 2333 ZC Leiden and Biostatistics, Department for Health Evidence, Radboud University Nijmegen Medical Center, 6500 HB Nijmegen, The Netherlands.

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http://dx.doi.org/10.1093/bioinformatics/btu654DOI Listing
February 2015

Differential methylation within the major histocompatibility complex region in rheumatoid arthritis: a replication study.

Rheumatology (Oxford) 2014 Dec 30;53(12):2317-8. Epub 2014 Sep 30.

Department of Rheumatology, Department of Molecular Epidemiology, Department of Medical Statistics and Bioinformatics, Leiden University Medical Center, Leiden, The Netherlands and Ignyta, Inc., San Diego, CA, USA.

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http://dx.doi.org/10.1093/rheumatology/keu380DOI Listing
December 2014

MethylAid: visual and interactive quality control of large Illumina 450k datasets.

Bioinformatics 2014 Dec 21;30(23):3435-7. Epub 2014 Aug 21.

Department of Molecular Epidemiology, Leiden University Medical Center, 2333 ZC Leiden, the Netherlands.

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http://dx.doi.org/10.1093/bioinformatics/btu566DOI Listing
December 2014

Epigenetic variation in monozygotic twins: a genome-wide analysis of DNA methylation in buccal cells.

Genes (Basel) 2014 May 5;5(2):347-65. Epub 2014 May 5.

Department of Biological Psychology, VU University Amsterdam, Van der Boechorststraat 1, 1081 BT Amsterdam, The Netherlands.

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http://dx.doi.org/10.3390/genes5020347DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4094937PMC
May 2014

Genome-wide association meta-analysis of human longevity identifies a novel locus conferring survival beyond 90 years of age.

Hum Mol Genet 2014 Aug 31;23(16):4420-32. Epub 2014 Mar 31.

Department of Molecular Epidemiology, Netherlands Consortium for Healthy Ageing,

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http://dx.doi.org/10.1093/hmg/ddu139DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4103672PMC
August 2014

DNA methylation of IGF2DMR and H19 is associated with fetal and infant growth: the generation R study.

PLoS One 2013 12;8(12):e81731. Epub 2013 Dec 12.

Department of Obstetrics and Gynecology, Erasmus Medical Centre, Rotterdam, The Netherlands ; Department of Clinical Genetics, Erasmus Medical Centre, Rotterdam, The Netherlands.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0081731PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3861253PMC
September 2014

DNA methylation profiles at birth and child ADHD symptoms.

J Psychiatr Res 2014 Feb 7;49:51-9. Epub 2013 Nov 7.

Department of Child and Adolescent Psychiatry, Erasmus MC, University Medical Center Rotterdam, Dr. Molewaterplein 50, 3015 GE Rotterdam, The Netherlands; Department of Epidemiology, Erasmus MC, University Medical Center Rotterdam, Dr. Molewaterplein 50, 3015 GE Rotterdam, The Netherlands; Department of Psychiatry, Erasmus MC, University Medical Center Rotterdam, Dr. Molewaterplein 50, 3015 GE Rotterdam, The Netherlands. Electronic address:

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http://dx.doi.org/10.1016/j.jpsychires.2013.10.017DOI Listing
February 2014

Duration of breastfeeding and gender are associated with methylation of the LEPTIN gene in very young children.

Pediatr Res 2013 Sep 11;74(3):344-9. Epub 2013 Jun 11.

Department of Obstetrics and Gynecology, Erasmus MC, Rotterdam, The Netherlands.

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http://dx.doi.org/10.1038/pr.2013.95DOI Listing
September 2013

From promises to practical strategies in epigenetic epidemiology.

Nat Rev Genet 2013 Aug 2;14(8):585-94. Epub 2013 Jul 2.

University of Exeter Medical School, Exeter University, St Luke's Campus, Magdalen Street, Exeter EX1 2LU, UK.

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http://www.nature.com/articles/nrg3405
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http://dx.doi.org/10.1038/nrg3405DOI Listing
August 2013

Commentary: The seven plagues of epigenetic epidemiology.

Int J Epidemiol 2012 Feb 23;41(1):74-8. Epub 2012 Jan 23.

Molecular Epidemiology, Leiden University Medical Center, Leiden, The Netherlands, Netherlands.

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https://academic.oup.com/ije/article-lookup/doi/10.1093/ije/
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http://dx.doi.org/10.1093/ije/dyr225DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3304528PMC
February 2012

Lipid metabolism in long-lived families: the Leiden Longevity Study.

Age (Dordr) 2011 Jun 3;33(2):219-27. Epub 2010 Sep 3.

Molecular Epidemiology Section, Department Medical Statistics and Bioinformatics, Leiden University Medical Centre, RC, Leiden, The Netherlands.

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http://dx.doi.org/10.1007/s11357-010-9172-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3127468PMC
June 2011

Variation, patterns, and temporal stability of DNA methylation: considerations for epigenetic epidemiology.

FASEB J 2010 Sep 12;24(9):3135-44. Epub 2010 Apr 12.

Department of Molecular Epidemiology, Leiden University Medical Center, Postal Zone S-05-P, PO box 9600, 2300RC, Leiden, The Nethelands.

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http://www.fasebj.org/doi/10.1096/fj.09-150490
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http://dx.doi.org/10.1096/fj.09-150490DOI Listing
September 2010

Human insulin/IGF-1 and familial longevity at middle age.

Aging (Albany NY) 2009 Jul 24;1(8):714-22. Epub 2009 Jul 24.

Department of Gerontology and Geriatrics, Leiden University Medical Center, 2300 RC, Leiden, the Netherlands.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2806046PMC
http://dx.doi.org/10.18632/aging.100071DOI Listing
July 2009

Low serum free triiodothyronine levels mark familial longevity: the Leiden Longevity Study.

J Gerontol A Biol Sci Med Sci 2010 Apr 16;65(4):365-8. Epub 2009 Dec 16.

Department of Gerontology and Geriatrics, Leiden University Medical Center, PO Box 9600, 2300 RC, Leiden, The Netherlands.

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http://dx.doi.org/10.1093/gerona/glp200DOI Listing
April 2010

The epigenome: archive of the prenatal environment.

Epigenetics 2009 Nov 6;4(8):526-31. Epub 2009 Nov 6.

Molecular Epidemiology, Leiden University Medical Center, Leiden, The Netherlands.

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http://dx.doi.org/10.4161/epi.4.8.10265DOI Listing
November 2009

Nonagenarian siblings and their offspring display lower risk of mortality and morbidity than sporadic nonagenarians: The Leiden Longevity Study.

J Am Geriatr Soc 2009 Sep 17;57(9):1634-7. Epub 2009 Jul 17.

Department of Gerontology and Geriatrics, Leiden University Medical Centre, PO Box 9600, 2300 RC Leiden, The Netherlands.

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http://dx.doi.org/10.1111/j.1532-5415.2009.02381.xDOI Listing
September 2009

DNA methylation differences after exposure to prenatal famine are common and timing- and sex-specific.

Hum Mol Genet 2009 Nov 4;18(21):4046-53. Epub 2009 Aug 4.

Molecular Epidemiology, Leiden University Medical Center, Leiden 2300 RC, The Netherlands.

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http://dx.doi.org/10.1093/hmg/ddp353DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2758137PMC
November 2009

Epigenetic histone acetylation modifiers in vascular remodelling: new targets for therapy in cardiovascular disease.

Eur Heart J 2009 Feb 15;30(3):266-77. Epub 2009 Jan 15.

Department of Cardiology, Leiden University Medical Center, C5-P, PO Box 9600, 2300 RC Leiden, The Netherlands.

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http://dx.doi.org/10.1093/eurheartj/ehn603DOI Listing
February 2009

Persistent epigenetic differences associated with prenatal exposure to famine in humans.

Proc Natl Acad Sci U S A 2008 Nov 27;105(44):17046-9. Epub 2008 Oct 27.

Departments of Molecular Epidemiology, Medical Statistics, and Gerontology and Geriatrics, Leiden University Medical Center, Leiden, The Netherlands.

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http://dx.doi.org/10.1073/pnas.0806560105DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2579375PMC
November 2008

Molecular epidemiology, candidate genes versus genome-wide scans.

Genes Nutr 2007 Oct;2(1):27-9

Department of Molecular Epidemiology, Leiden University Medical Centre, Research Building S5-P, PO Box 9600, 2300 RC, Leiden, The Netherlands,

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http://genesandnutrition.biomedcentral.com/articles/10.1007/
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http://dx.doi.org/10.1007/s12263-007-0002-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2474924PMC
October 2007

Heritable rather than age-related environmental and stochastic factors dominate variation in DNA methylation of the human IGF2/H19 locus.

Hum Mol Genet 2007 Mar 5;16(5):547-54. Epub 2007 Mar 5.

Molecular Epidemiology Section, Leiden University Medical Centre, Leiden 2333 ZC, The Netherlands.

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http://academic.oup.com/hmg/article/16/5/547/708270/Heritabl
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http://dx.doi.org/10.1093/hmg/ddm010DOI Listing
March 2007

Sex-limited genome-wide linkage scan for body mass index in an unselected sample of 933 Australian twin families.

Twin Res Hum Genet 2005 Dec;8(6):616-32

Genetic Epidemiology, Queensland Institute of Medical Research, Post Office Royal Brisbane Hospital, QLD, Australia

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December 2005

Reduced insulin/IGF-1 signalling and human longevity.

Aging Cell 2005 Apr;4(2):79-85

Section of Gerontology and Geriatrics, Department of General Internal Medicine, Leiden University Medical Centre, PO Box 9600, 2300 RC Leiden, The Netherlands.

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http://diyhpl.us/~bryan/papers2/longevity/Reduced%20insulin-
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http://doi.wiley.com/10.1111/j.1474-9728.2005.00148.x
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http://dx.doi.org/10.1111/j.1474-9728.2005.00148.xDOI Listing
April 2005

Impaired innate immunity predicts frailty in old age. The Leiden 85-plus study.

Exp Gerontol 2004 Sep;39(9):1407-14

Department of General Internal Medicine, Section Gerontology and Geriatrics, Leiden University Medical Center, C2-R, Albinusdreef 2, P.O. Box 9600, 2300 RC Leiden, the Netherlands.

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http://www.leidenlangleven.nl/uploads/publicaties/2004/2004_
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http://linkinghub.elsevier.com/retrieve/pii/S053155650400213
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http://dx.doi.org/10.1016/j.exger.2004.06.009DOI Listing
September 2004

Transcription of the IL10 gene reveals allele-specific regulation at the mRNA level.

Hum Mol Genet 2004 Aug 15;13(16):1755-62. Epub 2004 Jun 15.

Department of Rheumatology, Leiden University Medical Centre, The Netherlands.

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http://dx.doi.org/10.1093/hmg/ddh187DOI Listing
August 2004

Further evidence for a QTL influencing body mass index on chromosome 7p from a genome-wide scan in Dutch families.

Twin Res 2004 Apr;7(2):192-6

Molecular Epidemiology Section, Leiden University Medical Centre, Leiden, the Netherlands.

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http://dx.doi.org/10.1375/136905204323016177DOI Listing
April 2004