Basil Rigas

Basil Rigas

UNVERIFIED PROFILE

Are you Basil Rigas?   Register this Author

Register author
Basil Rigas

Basil Rigas

Publications by authors named "Basil Rigas"

Are you Basil Rigas?   Register this Author

100Publications

1038Reads

37Profile Views

Establishment of a Severe Dry Eye Model Using Complete Dacryoadenectomy in Rabbits.

J Vis Exp 2020 Jan 8(155). Epub 2020 Jan 8.

Department of Medicine, Stony Brook University; Department of Preventive Medicine, Stony Brook University.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3791/60126DOI Listing
January 2020

A Rabbit Model of Aqueous-Deficient Dry Eye Disease Induced by Concanavalin A Injection into the Lacrimal Glands: Application to Drug Efficacy Studies.

J Vis Exp 2020 Jan 24(155). Epub 2020 Jan 24.

Department of Preventive Medicine, Stony Brook University.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3791/59631DOI Listing
January 2020

A New Rabbit Model of Chronic Dry Eye Disease Induced by Complete Surgical Dacryoadenectomy.

Curr Eye Res 2019 Aug 15;44(8):863-872. Epub 2019 Apr 15.

e Department of Preventive Medicine, Stony Brook University , Stony Brook , NY , USA.

View Article

Download full-text PDF

Source
https://www.tandfonline.com/doi/full/10.1080/02713683.2019.1
Publisher Site
http://dx.doi.org/10.1080/02713683.2019.1594933DOI Listing
August 2019

NSAID-induced corneal melt: Clinical importance, pathogenesis, and risk mitigation.

Surv Ophthalmol 2020 Jan - Feb;65(1):1-11. Epub 2019 Jul 12.

Department of Ophthalmology, Stony Brook University, Stony Brook, New York, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.survophthal.2019.07.001DOI Listing
July 2019

Correction: The Chemoprevention of Ovarian Cancer: the Need and the Options.

Curr Pharmacol Rep 2018;4(5):414. Epub 2018 Sep 10.

Department of Medicine, Stony Brook University, Stony Brook, NY USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s40495-018-0159-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6208779PMC
September 2018

Phosphosulindac is efficacious in an improved concanavalin A-based rabbit model of chronic dry eye disease.

Transl Res 2018 08 10;198:58-72. Epub 2018 Apr 10.

Department of Medicine, Stony Brook University, Stony Brook, New York. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.trsl.2018.04.002DOI Listing
August 2018

The Chemoprevention of Ovarian Cancer: the Need and the Options.

Curr Pharmacol Rep 2018 2;4(3):250-260. Epub 2018 May 2.

Department of Medicine, Stony Brook University, Stony Brook, NY USA.

View Article

Download full-text PDF

Source
http://link.springer.com/10.1007/s40495-018-0133-6
Publisher Site
http://dx.doi.org/10.1007/s40495-018-0133-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6182352PMC
May 2018

Alkaline Ceramidase 1 Protects Mice from Premature Hair Loss by Maintaining the Homeostasis of Hair Follicle Stem Cells.

Stem Cell Reports 2017 11 19;9(5):1488-1500. Epub 2017 Oct 19.

Department of Medicine, Stony Brook University, Stony Brook, NY, USA; Department of Medicine and Stony Brook Cancer Center, Stony Brook University, HSC T15-023, Stony Brook, NY 11794, USA; Graduate Program in Molecular and Cellular Biology, Stony Brook University, Stony Brook, NY, USA; Department of Dermatology, Stony Brook University, Stony Brook, NY, USA. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.stemcr.2017.09.015DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5829345PMC
November 2017

Phospho-Aspirin (MDC-22) Prevents Pancreatic Carcinogenesis in Mice.

Cancer Prev Res (Phila) 2016 Jul 2;9(7):624-34. Epub 2016 May 2.

Department of Medicine, Stony Brook University, Stony Brook, New York. Department of Family, Population and Preventive Medicine, Stony Brook University, Stony Brook, New York. Stony Brook Cancer Center, Stony Brook University, Stony Brook, New York.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1158/1940-6207.CAPR-15-0344DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4930743PMC
July 2016

NSAIDs and Colorectal Cancer Control: Promise and Challenges.

Curr Pharmacol Rep 2015 Oct 14;1(5):295-301. Epub 2015 May 14.

Stony Brook University, HSC, L4, Room 169, Stony Brook, NY 11794-8430, Tel: 631-638-2141;

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s40495-015-0042-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4683110PMC
October 2015

Phospho-aspirin-2 (MDC-22) inhibits estrogen receptor positive breast cancer growth both in vitro and in vivo by a redox-dependent effect.

PLoS One 2014 4;9(11):e111720. Epub 2014 Nov 4.

Division of Cancer Prevention, Department of Medicine, Stony Brook University, Stony Brook, New York, United States of America; Medicon Pharmaceuticals, Inc, Setauket, New York, United States of America.

View Article

Download full-text PDF

Source
http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0111720PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4219766PMC
June 2015

Phospho-NSAIDs have enhanced efficacy in mice lacking plasma carboxylesterase: implications for their clinical pharmacology.

Pharm Res 2015 May 13;32(5):1663-75. Epub 2014 Nov 13.

Division of Cancer Prevention, Department of Medicine, Stony Brook University, HSC, T-17 Room 080, Stony Brook, NY, 11794-8173, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s11095-014-1565-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4382427PMC
May 2015

The evolving role of nonsteroidal anti-inflammatory drugs in colon cancer prevention: a cause for optimism.

J Pharmacol Exp Ther 2015 Apr;353(1):2-8

Department of Medicine, Stony Brook University, Stony Brook, NY, USA. basil.rigas@stonybrookmedicine

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1124/jpet.114.220806DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4366757PMC
April 2015

Repurposing the antipsychotic trifluoperazine as an antimetastasis agent.

Mol Pharmacol 2015 31;87(3):501-12. Epub 2014 Dec 31.

Department of Pharmacological Sciences/Cancer Prevention (A.P.G.), Department of Medicine/Cancer Prevention (C.Z., Y.L., B.R., J.C.), and Department of Medicine/Hematology & Oncology (S.Z.), Stony Brook University, Stony Brook, New York; Jimei University, Xiamen, China (J.L.); and Department of Pathology, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, China (N.O.)

View Article

Download full-text PDF

Source
http://molpharm.aspetjournals.org/content/87/3/501.full.pdf
Web Search
http://molpharm.aspetjournals.org/cgi/doi/10.1124/mol.114.09
Publisher Site
http://dx.doi.org/10.1124/mol.114.096941DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4419284PMC
March 2015

A novel ibuprofen derivative with anti-lung cancer properties: synthesis, formulation, pharmacokinetic and efficacy studies.

Int J Pharm 2014 Dec 11;477(1-2):236-43. Epub 2014 Oct 11.

Division of Cancer Prevention, Department of Medicine, Stony Brook University, Stony Brook, NY, USA. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.ijpharm.2014.10.019DOI Listing
December 2014

Pegylation improves the pharmacokinetics and bioavailability of small-molecule drugs hydrolyzable by esterases: a study of phospho-Ibuprofen.

J Pharmacol Exp Ther 2014 Oct 21;351(1):61-6. Epub 2014 Jul 21.

Department of Medicine, Stony Brook University, Stony Brook, New York (G.M., C.C.W., Y.S., C.A.A., R.R., B.R.); and Medicon Pharmaceuticals, Inc. (P.P.C., B.R.), Stony Brook, New York

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1124/jpet.114.217208DOI Listing
October 2014

The in vitro metabolism of phospho-sulindac amide, a novel potential anticancer agent.

Biochem Pharmacol 2014 Sep 18;91(2):249-55. Epub 2014 Jul 18.

Division of Cancer Prevention, Department of Medicine, Stony Brook University, Stony Brook, NY 11794, USA; Medicon Pharmaceuticals, Inc., Stony Brook, NY 11790, USA. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.bcp.2014.07.007DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4142141PMC
September 2014

Phospho-sulindac inhibits pancreatic cancer growth: NFATc1 as a drug resistance candidate.

Int J Oncol 2014 Feb 27;44(2):521-9. Epub 2013 Nov 27.

Division of Cancer Prevention, Department of Medicine, Stony Brook University, Stony Brook, NY 11794-8173, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3892/ijo.2013.2190DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3898803PMC
February 2014

A novel Ras inhibitor (MDC-1016) reduces human pancreatic tumor growth in mice.

Neoplasia 2013 Oct;15(10):1184-95

Division of Cancer Prevention, Department of Medicine, Stony Brook University, Stony Brook, NY ; Department of Preventive Medicine, Stony Brook University, Stony Brook, NY.

View Article

Download full-text PDF

Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3819634PMC
http://dx.doi.org/10.1593/neo.131368DOI Listing
October 2013

Curcumin enhances the lung cancer chemopreventive efficacy of phospho-sulindac by improving its pharmacokinetics.

Int J Oncol 2013 Sep 27;43(3):895-902. Epub 2013 Jun 27.

Division of Cancer Prevention, Department of Medicine, Stony Brook University, Stony Brook, NY 11794-8173, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3892/ijo.2013.1995DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3787887PMC
September 2013

Aerosol administration of phospho-sulindac inhibits lung tumorigenesis.

Mol Cancer Ther 2013 Aug 3;12(8):1417-28. Epub 2013 May 3.

Division of Cancer Prevention, Stony Brook University, Stony Brook, NY 11794, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1158/1535-7163.MCT-13-0006-TDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3780561PMC
August 2013

Topically applied phospho-sulindac hydrogel is efficacious and safe in the treatment of experimental arthritis in rats.

Pharm Res 2013 Jun 13;30(6):1471-82. Epub 2013 Mar 13.

Division of Cancer Prevention, Department of Medicine, Stony Brook University, HSC T17-080, Stony Brook, New York 11794-8173, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s11095-012-0953-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4395004PMC
June 2013

The anticancer effect of phospho-tyrosol-indomethacin (MPI-621), a novel phosphoderivative of indomethacin: in vitro and in vivo studies.

Carcinogenesis 2013 Apr 21;34(4):943-51. Epub 2013 Jan 21.

Division of Cancer Prevention, Department of Medicine, Stony Brook University, Stony Brook, NY 11794-8175, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1093/carcin/bgs394DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3616666PMC
April 2013

Comparative in vitro metabolism of phospho-tyrosol-indomethacin by mice, rats and humans.

Biochem Pharmacol 2013 Apr 8;85(8):1195-202. Epub 2013 Feb 8.

Division of Cancer Prevention, Department of Medicine, Stony Brook University, HSC, T17-080, Stony Brook, NY 11794, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.bcp.2013.01.031DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3604040PMC
April 2013

Platinum folate nanoparticles toxicity: cancer vs. normal cells.

Toxicol In Vitro 2013 Mar 11;27(2):882-9. Epub 2013 Jan 11.

Department of Medicine, Stem Cell Facility, Stony Brook University, Stony Brook, NY 11794, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.tiv.2013.01.005DOI Listing
March 2013

In vitro and in vivo metabolic studies of phospho-aspirin (MDC-22).

Pharm Res 2012 Dec 11;29(12):3292-301. Epub 2012 Jul 11.

Stony Brook University, Division of Cancer Prevention, HSC, T17-080, Stony Brook, New York 11794-8175, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s11095-012-0821-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3602912PMC
December 2012

FT-IR microspectroscopy of mouse colon tissues: insight into the chemistry of carcinogenesis and diagnostic potential.

Am J Pathol 2012 Dec 10;181(6):1961-8. Epub 2012 Oct 10.

Department of Integrated Science and Technology, Marshall University, Huntington, West Virginia, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.ajpath.2012.08.039DOI Listing
December 2012

MC-12, an annexin A1-based peptide, is effective in the treatment of experimental colitis.

PLoS One 2012 23;7(7):e41585. Epub 2012 Jul 23.

Department of Medicine, Stony Brook University, Stony Brook, New York, United States of America.

View Article

Download full-text PDF

Source
http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0041585PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3402399PMC
November 2012

Phosphosulindac (OXT-328) selectively targets breast cancer stem cells in vitro and in human breast cancer xenografts.

Stem Cells 2012 Oct;30(10):2065-75

Division of Cancer Prevention, Department of Medicine, Stony Brook University, Stony Brook, New York 11794-8173, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/stem.1139DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3621090PMC
October 2012

Topical phospho-sulindac (OXT-328) is effective in the treatment of non-melanoma skin cancer.

Int J Oncol 2012 Oct 27;41(4):1199-203. Epub 2012 Jul 27.

Division of Cancer Prevention, Department of Medicine, Stony Brook University, Stony Brook, NY, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3892/ijo.2012.1577DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3583614PMC
October 2012

Nanodelivery strategies in cancer chemotherapy: biological rationale and pharmaceutical perspectives.

Nanomedicine (Lond) 2012 Oct;7(10):1577-90

Division of Cancer Prevention, Department of Medicine, Stony Brook University, Stony Brook, NY, USA.

View Article

Download full-text PDF

Source
https://www.futuremedicine.com/doi/10.2217/nnm.12.128
Publisher Site
http://dx.doi.org/10.2217/nnm.12.128DOI Listing
October 2012

Sterically stabilized liposomes incorporating the novel anticancer agent phospho-ibuprofen (MDC-917): preparation, characterization, and in vitro/in vivo evaluation.

Pharm Res 2012 Jun 10;29(6):1435-43. Epub 2011 Nov 10.

Division of Cancer Prevention, Department of Medicine, Stony Brook University Stony Brook, Stony Brook, New York 11794-8173, USA.

View Article

Download full-text PDF

Source
http://link.springer.com/10.1007/s11095-011-0619-y
Publisher Site
http://dx.doi.org/10.1007/s11095-011-0619-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4428579PMC
June 2012

Preclinical predictors of anticancer drug efficacy: critical assessment with emphasis on whether nanomolar potency should be required of candidate agents.

J Pharmacol Exp Ther 2012 Jun 23;341(3):572-8. Epub 2012 Mar 23.

Division of Cancer Prevention, Department of Medicine, Stony Brook University, Stony Brook, New York 11794-8173, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1124/jpet.112.191957DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3362883PMC
June 2012

Carboxylesterases 1 and 2 hydrolyze phospho-nonsteroidal anti-inflammatory drugs: relevance to their pharmacological activity.

J Pharmacol Exp Ther 2012 Feb 15;340(2):422-32. Epub 2011 Nov 15.

Division of Cancer Prevention, Department of Medicine, Stony Brook University, Stony Brook, New York 11794-8173, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1124/jpet.111.188508DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3263964PMC
February 2012

Phospho-ibuprofen (MDC-917) suppresses breast cancer growth: an effect controlled by the thioredoxin system.

Breast Cancer Res 2012 Jan 31;14(1):R20. Epub 2012 Jan 31.

Division of Cancer Prevention, Department of Medicine, Stony Brook University, Stony Brook, NY 11794-8173, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/bcr3105DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3496138PMC
January 2012

Chemotherapeutic properties of phospho-nonsteroidal anti-inflammatory drugs, a new class of anticancer compounds.

Cancer Res 2011 Dec 24;71(24):7617-27. Epub 2011 Oct 24.

Department of Medicine, Division of Cancer Prevention, Stony Brook University, Stony Brook, New York 11794, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1158/0008-5472.CAN-11-2349DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3242900PMC
December 2011

Structure-activity relationship study of novel anticancer aspirin-based compounds.

Mol Med Rep 2011 Sep-Oct;4(5):891-9. Epub 2011 Jul 6.

Division of Cancer Prevention, Department of Medicine, Stony Brook University, Health Sciences Center T17-080, Stony Brook, NY 11794-8173, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3892/mmr.2011.534DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3565583PMC
November 2011

Oxidative stress mediates through apoptosis the anticancer effect of phospho-nonsteroidal anti-inflammatory drugs: implications for the role of oxidative stress in the action of anticancer agents.

J Pharmacol Exp Ther 2011 Sep 6;338(3):775-83. Epub 2011 Jun 6.

Division of Cancer Prevention, Department of Medicine, Stony Brook University, Stony Brook, New York, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1124/jpet.111.183533DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3164348PMC
September 2011

NO-Donating NSAIDs, PPARdelta, and Cancer: Does PPARdelta Contribute to Colon Carcinogenesis?

PPAR Res 2008 ;2008:919572

Division of Cancer Prevention, Department of Medicine, Stony Brook University, Stony Brook, NY 11794-5200, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1155/2008/919572DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2408682PMC
July 2011

Phospho-sulindac (OXT-328) combined with difluoromethylornithine prevents colon cancer in mice.

Cancer Prev Res (Phila) 2011 Jul 4;4(7):1052-60. Epub 2011 Apr 4.

Division of Cancer Prevention, Department of Medicine, Stony Brook University, Stony Brook, NY 11794, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1158/1940-6207.CAPR-11-0067DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3131469PMC
July 2011

Protein nitration and nitrosylation by NO-donating aspirin in colon cancer cells: Relevance to its mechanism of action.

Exp Cell Res 2011 Jun 22;317(10):1359-67. Epub 2011 Mar 22.

Division of Cancer Prevention, Stony Brook University, HSC, T17-080, Stony Brook, NY 11794-8173, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.yexcr.2011.03.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3096692PMC
June 2011

Phospho-ibuprofen (MDC-917) is a novel agent against colon cancer: efficacy, metabolism, and pharmacokinetics in mouse models.

J Pharmacol Exp Ther 2011 Jun 21;337(3):876-86. Epub 2011 Mar 21.

Division of Cancer Prevention, Department of Medicine, Stony Brook University, Stony Brook, NY 11794-8173, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1124/jpet.111.180224DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3101013PMC
June 2011

Phospho-sulindac (OXT-922) inhibits the growth of human colon cancer cell lines: a redox/polyamine-dependent effect.

Carcinogenesis 2010 Nov 12;31(11):1982-90. Epub 2010 Jul 12.

Division of Cancer Prevention, Department of Medicine, Stony Brook University, Stony Brook, NY 11794, USA.

View Article

Download full-text PDF

Source
https://academic.oup.com/carcin/article-lookup/doi/10.1093/c
Publisher Site
http://dx.doi.org/10.1093/carcin/bgq149DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2966552PMC
November 2010

Phospho-sulindac (OXT-328), a novel sulindac derivative, is safe and effective in colon cancer prevention in mice.

Gastroenterology 2010 Oct 20;139(4):1320-32. Epub 2010 Jun 20.

Division of Cancer Prevention, Department of Medicine, Stony Brook University, Stony Brook, New York 11794-8173, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1053/j.gastro.2010.06.044DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2949489PMC
October 2010

Annexin 1 induced by anti-inflammatory drugs binds to NF-kappaB and inhibits its activation: anticancer effects in vitro and in vivo.

Cancer Res 2010 Mar 9;70(6):2379-88. Epub 2010 Mar 9.

Division of Cancer Prevention, Department of Medicine, Stony Brook University, Stony Brook, New York 11794-8173, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1158/0008-5472.CAN-09-4204DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2953961PMC
March 2010

Regulation of peroxisome proliferator-activated receptor-beta/delta by the APC/beta-CATENIN pathway and nonsteroidal antiinflammatory drugs.

Mol Carcinog 2009 Oct;48(10):942-52

Department of Veterinary and Biomedical Sciences, The Center for Molecular Toxicology and Carcinogenesis, The Pennsylvania State University, University Park, Pennsylvania 16802, USA.

View Article

Download full-text PDF

Source
http://doi.wiley.com/10.1002/mc.20546
Publisher Site
http://dx.doi.org/10.1002/mc.20546DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2790141PMC
October 2009

The differential cell signaling effects of two positional isomers of the anticancer NO-donating aspirin.

Int J Oncol 2009 Oct;35(4):837-44

Division of Cancer Prevention, Department of Medicine, Stony Brook University, Stony Brook, New York 11794-5200, USA.

View Article

Download full-text PDF

Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3565755PMC
http://dx.doi.org/10.3892/ijo_00000397DOI Listing
October 2009

Phosphoaspirin (MDC-43), a novel benzyl ester of aspirin, inhibits the growth of human cancer cell lines more potently than aspirin: a redox-dependent effect.

Carcinogenesis 2009 Mar 9;30(3):512-9. Epub 2009 Jan 9.

Department of Medicine, Division of Cancer Prevention, Stony Brook University, Stony Brook, NY 11794-5200, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1093/carcin/bgp015DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2650796PMC
March 2009

Food components, alternative medicine, and cancer: progress and promise.

Nutr Cancer 2008 ;60 Suppl 1

Division of Cancer Prevention, Stony Brook University, Life Sciences Building, Room 006, Stony Brook, NY 11794-5200, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1080/01635580802393134DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2596752PMC
February 2009

Nitric oxide-donating aspirin inhibits the growth of pancreatic cancer cells through redox-dependent signaling.

Cancer Lett 2009 Jan 20;273(2):292-9. Epub 2008 Sep 20.

Division of Cancer Prevention, Stony Brook University, Life Sciences Building, Room 006, Stony Brook, NY 11794-5200, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.canlet.2008.08.006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2649683PMC
January 2009

Chemopreventive agents induce oxidative stress in cancer cells leading to COX-2 overexpression and COX-2-independent cell death.

Carcinogenesis 2009 Jan 24;30(1):93-100. Epub 2008 Oct 24.

Division of Cancer Prevention, Stony Brook University, Life Sciences Building, Stony Brook, NY 11794-5200, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1093/carcin/bgn242DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2639032PMC
January 2009

Pharmacokinetic and pharmacodynamic study of NO-donating aspirin in F344 rats.

Int J Oncol 2008 Oct;33(4):799-805

Department of Medicine, Hematology-Oncology Section, University of Oklahoma Health Sciences Center, Oklahoma City, OK 73104, USA.

View Article

Download full-text PDF

Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2579329PMC
http://dx.doi.org/10.3892/ijo_00000067DOI Listing
October 2008

Dietary induction of colonic tumors in a mouse model of sporadic colon cancer.

Cancer Res 2008 Oct;68(19):7803-10

Strang Cancer Research Laboratory, Department of Medicine, Gastroenterology and Hepatology, Weill Medical College of Cornell University, New York, New York 10467, USA.

View Article

Download full-text PDF

Source
http://cancerres.aacrjournals.org/cgi/doi/10.1158/0008-5472.
Publisher Site
http://dx.doi.org/10.1158/0008-5472.CAN-08-1209DOI Listing
October 2008

The thioredoxin system mediates redox-induced cell death in human colon cancer cells: implications for the mechanism of action of anticancer agents.

Authors:
Yu Sun Basil Rigas

Cancer Res 2008 Oct;68(20):8269-77

Department of Medicine, Division of Cancer Prevention, Stony Brook University, Stony Brook, New York 11794-5200, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1158/0008-5472.CAN-08-2010DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3565581PMC
October 2008

NO-donating NSAIDs and cancer: an overview with a note on whether NO is required for their action.

Nitric Oxide 2008 Sep 29;19(2):199-204. Epub 2008 Apr 29.

Division of Cancer Prevention, Stony Brook University, Life Sciences Building, Stony Brook, NY 11794-5200, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.niox.2008.04.022DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2560981PMC
September 2008

A potentiometric protein sensor built with surface molecular imprinting method.

Biosens Bioelectron 2008 Sep 20;24(1):162-6. Epub 2008 Apr 20.

Department of Materials Science and Engineering, Stony Brook University, Stony Brook, NY 11794-2275, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.bios.2008.04.010DOI Listing
September 2008

NO-donating aspirin inhibits angiogenesis by suppressing VEGF expression in HT-29 human colon cancer mouse xenografts.

Carcinogenesis 2008 Sep 9;29(9):1794-8. Epub 2008 Jun 9.

Division of Cancer Prevention, Stony Brook University, Stony Brook, NY 11794, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1093/carcin/bgn127DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2527643PMC
September 2008

Screening for colorectal cancer: does it all start with aberrant crypt foci?

Gastrointest Endosc 2008 Jun;67(7):1103-5

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.gie.2007.10.038DOI Listing
June 2008

NO-donating aspirin inhibits the activation of NF-kappaB in human cancer cell lines and Min mice.

Carcinogenesis 2008 Feb 3;29(2):390-7. Epub 2008 Jan 3.

Division of Cancer Prevention, Department of Medicine, State University of New York at Stony Brook, Stony Brook, NY 11794-5200, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1093/carcin/bgm275DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2679698PMC
February 2008

The novel phenylester anticancer compounds: Study of a derivative of aspirin (phoshoaspirin).

Int J Oncol 2008 Jan;32(1):97-100

Division of Cancer Prevention, Stony Brook University, Stony Brook, NY 11794-5200, USA.

View Article

Download full-text PDF

Source
January 2008

Nitric oxide-donating aspirin derivatives suppress microsatellite instability in mismatch repair-deficient and hereditary nonpolyposis colorectal cancer cells.

Cancer Res 2007 Nov;67(22):10966-75

Department of Molecular Virology, Immunology, and Medical Genetics, The Ohio State University Comprehensive Cancer Center and Medical Center, Columbus, Ohio 43026, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1158/0008-5472.CAN-07-2562DOI Listing
November 2007

Development of novel agents based on nitric oxide for the control of colon cancer.

Acta Pharmacol Sin 2007 Sep;28(9):1429-33

Division of Cancer Prevention, Stony Brook University, Stony Brook, NY 11794-5200, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/j.1745-7254.2007.00696.xDOI Listing
September 2007

Molecular targets of calcium and vitamin D in mouse genetic models of intestinal cancer.

Nutr Rev 2007 Aug;65(8 Pt 2):S134-7

Strang Cancer Prevention Center, New York, New York, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/j.1753-4887.2007.tb00342.xDOI Listing
August 2007

The mechanism of action of nitric oxide-donating aspirin.

Biochem Biophys Res Commun 2007 Jul 15;358(4):1096-101. Epub 2007 May 15.

Department of Physiology and Pharmacology, City University of New York Medical School, New York, NY 10031, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.bbrc.2007.05.038DOI Listing
July 2007

The use of nitric oxide-donating nonsteroidal anti-inflammatory drugs in the chemoprevention of colorectal neoplasia.

Authors:
Basil Rigas

Curr Opin Gastroenterol 2007 Jan;23(1):55-9

Division of Cancer Prevention and Gastroenterology, Department of Medicine, Stony Brook University, Stony Brook, New York 11794, USA.

View Article

Download full-text PDF

Source
https://insights.ovid.com/crossref?an=00001574-200701000-000
Publisher Site
http://dx.doi.org/10.1097/MOG.0b013e32801145b0DOI Listing
January 2007

NF-kappaB, inflammation and pancreatic carcinogenesis: NF-kappaB as a chemoprevention target (review).

Int J Oncol 2006 Jul;29(1):185-92

Department of Medicine, Division of Cancer Prevention, SUNY at Stony Brook, Stony Brook, NY 11794-5200, USA.

View Article

Download full-text PDF

Source
July 2006

NO-donating aspirin induces phase II enzymes in vitro and in vivo.

Carcinogenesis 2006 Apr 2;27(4):803-10. Epub 2005 Nov 2.

Division of Cancer Prevention, Department of Medicine, SUNY at Stony Brook, NY 11794, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1093/carcin/bgi262DOI Listing
April 2006

Nitric oxide-donating aspirin prevents pancreatic cancer in a hamster tumor model.

Cancer Res 2006 Apr;66(8):4503-11

Division of Cancer Prevention, State University of New York at Stony Brook, Stony Brook, New York 11794-5200, USA.

View Article

Download full-text PDF

Source
http://cancerres.aacrjournals.org/lookup/doi/10.1158/0008-54
Publisher Site
http://dx.doi.org/10.1158/0008-5472.CAN-05-3118DOI Listing
April 2006

NO-donating aspirin isomers downregulate peroxisome proliferator-activated receptor (PPAR)delta expression in APC(min/+) mice proportionally to their tumor inhibitory effect: Implications for the role of PPARdelta in carcinogenesis.

Carcinogenesis 2006 Feb 1;27(2):232-9. Epub 2005 Sep 1.

Division of Cancer Prevention, Department of Medicine, SUNY at Stony Brook, Stony Brook, NY 11794-5200, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1093/carcin/bgi221DOI Listing
February 2006

Nitric oxide-donating aspirin inhibits colon cancer cell growth via mitogen-activated protein kinase activation.

J Pharmacol Exp Ther 2006 Jan 16;316(1):25-34. Epub 2005 Sep 16.

Division of Cancer Prevention, Department of Medicine, Life Sciences Bldg. 06, State University of New York at Stony Brook, Stony Brook, NY 11794-5200, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1124/jpet.105.091363DOI Listing
January 2006

Nitric oxide-releasing medications and colorectal cancer risk: the framingham study.

Anticancer Res 2005 Nov-Dec;25(6C):4471-4

Department of Health Evaluation Sciences, Penn State College of Medicine, Hershey, PA 17033, USA.

View Article

Download full-text PDF

Source
January 2006

Nitric oxide-donating aspirin induces apoptosis in human colon cancer cells through induction of oxidative stress.

Proc Natl Acad Sci U S A 2005 Nov 10;102(47):17207-12. Epub 2005 Nov 10.

Division of Cancer Prevention, Department of Medicine, Stony Brook University, Stony Brook, NY 11794-5200, USA.

View Article

Download full-text PDF

Source
http://www.pnas.org/cgi/doi/10.1073/pnas.0506893102
Publisher Site
http://dx.doi.org/10.1073/pnas.0506893102DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1287992PMC
November 2005

Non-COX-2 targets and cancer: expanding the molecular target repertoire of chemoprevention.

Biochem Pharmacol 2005 Oct;70(7):969-86

Department of Physiology and Pharmacology, City University of New York Medical School, 138th Street and Convent Avenue, New York, NY 10031, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.bcp.2005.05.004DOI Listing
October 2005

Cancer prevention: a new era beyond cyclooxygenase-2.

J Pharmacol Exp Ther 2005 Jul 1;314(1):1-8. Epub 2005 Apr 1.

Division of Cancer Prevention, Department of Medicine, SUNY at Stony Brook, Stony Brook, NY 11794-8160, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1124/jpet.104.080564DOI Listing
July 2005

In vitro metabolism of nitric oxide-donating aspirin: the effect of positional isomerism.

J Pharmacol Exp Ther 2005 Mar 4;312(3):989-97. Epub 2004 Nov 4.

Division of Cancer Prevention, Department of Medicine, SUNY at Stony Brook, Stony Brook, NY 11794-8160, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1124/jpet.104.076190DOI Listing
March 2005

Positional isomerism markedly affects the growth inhibition of colon cancer cells by nitric oxide-donating aspirin in vitro and in vivo.

J Pharmacol Exp Ther 2005 Mar 4;312(3):978-88. Epub 2004 Nov 4.

Division of Cancer Prevention, Department of Medicine, SUNY at Stony Brook, Stony Brook, NY 11794-8160, USA.

View Article

Download full-text PDF

Source
http://jpet.aspetjournals.org/cgi/doi/10.1124/jpet.104.07599
Publisher Site
http://dx.doi.org/10.1124/jpet.104.075994DOI Listing
March 2005

NO-donating aspirin inhibits the growth of leukemic Jurkat cells and modulates beta-catenin expression.

Biochem Biophys Res Commun 2005 Jan;326(1):93-9

Department of Physiology and Pharmacology, City University of New York Medical School, New York, NY 10031, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.bbrc.2004.11.009DOI Listing
January 2005

Nitric-oxide-donating NSAIDs as agents for cancer prevention.

Trends Mol Med 2004 Jul;10(7):324-30

Division of Cancer Prevention, Department of Medicine, SUNY at Stony Brook, Stony Brook, NY 11794-8160, USA.

View Article

Download full-text PDF

Source
http://linkinghub.elsevier.com/retrieve/pii/S147149140400126
Publisher Site
http://dx.doi.org/10.1016/j.molmed.2004.05.004DOI Listing
July 2004

NO-donating aspirin inhibits intestinal carcinogenesis in Min (APC(Min/+)) mice.

Biochem Biophys Res Commun 2004 Jan;313(3):784-8

American Health Foundation Cancer Center, Institute for Cancer Prevention, Valhalla, NY 06595, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.bbrc.2003.12.015DOI Listing
January 2004

Nitric oxide-donating aspirin inhibits beta-catenin/T cell factor (TCF) signaling in SW480 colon cancer cells by disrupting the nuclear beta-catenin-TCF association.

Proc Natl Acad Sci U S A 2003 Oct 17;100(22):12584-9. Epub 2003 Oct 17.

Department of Physiology and Pharmacology, City University of New York Medical School, New York, NY 10031.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1073/pnas.2134840100DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC240661PMC
October 2003

Insulin resistance and its contribution to colon carcinogenesis.

Exp Biol Med (Maywood) 2003 Apr;228(4):396-405

American Health Foundation, New York Medical College, Valhalla, New York 10595, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1177/153537020322800410DOI Listing
April 2003

Regional response leading to tumorigenesis after sulindac in small and large intestine of mice with Apc mutations.

Carcinogenesis 2003 Mar;24(3):605-11

Strang Cancer Research Laboratory at The Rockefeller University, 1230 York Avenue, New York, NY 10021, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1093/carcin/24.3.605DOI Listing
March 2003

The role of NSAIDs in the prevention of colon cancer.

Cancer Invest 2002 ;20(7-8):1002-11

Division of Gastroenterology, New York Medical College, NY, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1081/cnv-120005917DOI Listing
December 2002