Bart Vanhaesebroeck, PhD - University College London - Professor

Bart Vanhaesebroeck

PhD

University College London

Professor

London | United Kingdom

Bart Vanhaesebroeck, PhD - University College London - Professor

Bart Vanhaesebroeck

PhD

Introduction

Primary Affiliation: University College London - London , United Kingdom

Publications

103Publications

1973Reads

2Profile Views

3490PubMed Central Citations

Lessons for cancer drug treatment from tackling a non-cancerous overgrowth syndrome.

Nature 2018 06;558(7711):523-525

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http://dx.doi.org/10.1038/d41586-018-05365-wDOI Listing
June 2018
1 Citation
42.351 Impact Factor

Determinants and clinical implications of chromosomal instability in cancer.

Nat Rev Clin Oncol 2018 03 3;15(3):139-150. Epub 2018 Jan 3.

The Francis Crick Institute, 1 Midland Road, Kings Cross, London NW1 1AT, UK.

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http://dx.doi.org/10.1038/nrclinonc.2017.198DOI Listing
March 2018
26 Reads
3 Citations
14.180 Impact Factor

Clinical spectrum and features of activated phosphoinositide 3-kinase δ syndrome: A large patient cohort study.

J Allergy Clin Immunol 2017 02 16;139(2):597-606.e4. Epub 2016 Jul 16.

Department of Paediatric Immunology, Newcastle upon Tyne hospitals NHS Foundation Trust, Newcastle upon Tyne, United Kingdom; Institute of Cellular Medicine, Newcastle University, Newcastle upon Tyne Hospitals NHS Trust, Newcastle upon Tyne, United Kingdom.

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http://dx.doi.org/10.1016/j.jaci.2016.06.021DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5292996PMC
February 2017
145 Reads
31 Citations
11.480 Impact Factor

Phosphoproteomic comparison of Pik3ca and Pten signalling identifies the nucleotidase NT5C as a novel AKT substrate.

Sci Rep 2017 01 6;7:39985. Epub 2017 Jan 6.

UCL Cancer Institute, Paul O'Gorman Building, University College London, 72 Huntley Street London WC1E 6DD, UK.

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http://dx.doi.org/10.1038/srep39985DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5216349PMC
January 2017
29 Reads
4 Citations
5.080 Impact Factor

Phosphoinositide 3-kinase: a new kid on the block in vascular anomalies.

J Pathol 2016 12 20;240(4):387-396. Epub 2016 Oct 20.

UCL Institute of Child Health & Great Ormond Street Hospital for Children, London, UK.

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http://dx.doi.org/10.1002/path.4802DOI Listing
December 2016
9 Reads
2 Citations
7.430 Impact Factor

Targeting PI3K in Cancer: Impact on Tumor Cells, Their Protective Stroma, Angiogenesis, and Immunotherapy.

Cancer Discov 2016 10 21;6(10):1090-1105. Epub 2016 Sep 21.

UCL Cancer Institute, University College London, London, United Kingdom.

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http://dx.doi.org/10.1158/2159-8290.CD-16-0716DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5293166PMC
October 2016
1 Read
24 Citations
15.930 Impact Factor

Inactivation of class II PI3K-C2α induces leptin resistance, age-dependent insulin resistance and obesity in male mice.

Diabetologia 2016 07 30;59(7):1503-1512. Epub 2016 Apr 30.

UCL Cancer Institute, University College London, 72 Huntley Street, London, WC1E 6DD, UK.

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http://dx.doi.org/10.1007/s00125-016-3963-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4901096PMC
July 2016
2 Reads
1 Citation
6.671 Impact Factor

The class I phosphoinositide 3-kinases α and β control antiphospholipid antibodies-induced platelet activation.

Thromb Haemost 2016 06 28;115(6):1138-46. Epub 2016 Jan 28.

Anne-Dominique Terrisse, Inserm U1048, I2MC, 1 Avenue Jean Poulhés, BP 84225, 31432 Toulouse Cedex 04, France, Tel.: +33 5 3122 4150, Fax: +33 5 6132 5621, E-mail:

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http://dx.doi.org/10.1160/TH15-08-0661DOI Listing
June 2016
10 Reads
1 Citation
4.984 Impact Factor

Plasma Metabolomic Changes following PI3K Inhibition as Pharmacodynamic Biomarkers: Preclinical Discovery to Phase I Trial Evaluation.

Mol Cancer Ther 2016 06 5;15(6):1412-24. Epub 2016 Apr 5.

Cancer Research UK Cancer Therapeutics Unit, The Institute of Cancer Research, London, United Kingdom. Drug Development Unit, The Royal Marsden NHS Foundation Trust, Sutton, United Kingdom.

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http://dx.doi.org/10.1158/1535-7163.MCT-15-0815DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5321508PMC
June 2016
59 Reads
3 Citations
5.683 Impact Factor

Molecules in medicine mini-review: isoforms of PI3K in biology and disease.

J Mol Med (Berl) 2016 Jan 10;94(1):5-11. Epub 2015 Dec 10.

UCL Cancer Institute, University College London, 72 Huntley Street, London, WC1E 6BT, UK.

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http://dx.doi.org/10.1007/s00109-015-1352-5DOI Listing
January 2016
3 Reads
17 Citations
5.110 Impact Factor

Essential role of class II PI3K-C2α in platelet membrane morphology.

Blood 2015 Aug 24;126(9):1128-37. Epub 2015 Jun 24.

Inserm, U1048-Université Toulouse III, Institut des Maladies Métaboliques et Cardiovasculaires, Toulouse, France;

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http://dx.doi.org/10.1182/blood-2015-03-636670DOI Listing
August 2015
3 Reads
5 Citations
10.452 Impact Factor

PI3Kα is essential for the recovery from Cre/tamoxifen cardiotoxicity and in myocardial insulin signalling but is not required for normal myocardial contractility in the adult heart.

Cardiovasc Res 2015 Mar 24;105(3):292-303. Epub 2015 Jan 24.

Department of Physiology, University of Alberta, Edmonton, Alberta, Canada Mazankowski Alberta Heart Institute, University of Alberta, Edmonton, Alberta, Canada Division of Cardiology, Department of Medicine, University of Alberta, Mazankowski Alberta Heart Institute, Edmonton, Alberta, Canada

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http://dx.doi.org/10.1093/cvr/cvv016DOI Listing
March 2015
14 Reads
2 Citations
5.940 Impact Factor

Platelet PI3Kβ and GSK3 regulate thrombus stability at a high shear rate.

Blood 2015 Jan 14;125(5):881-8. Epub 2014 Nov 14.

INSERM, U1048 and Université Toulouse III, Institut de Maladies Métaboliques et Cardiovasculaires, Centre Hospitalier Universitaire-Rangueil, Toulouse, France;

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http://dx.doi.org/10.1182/blood-2014-07-588335DOI Listing
January 2015
8 Reads
8 Citations
10.452 Impact Factor

Cinderella finds her shoe: the first Vps34 inhibitor uncovers a new PI3K-AGC protein kinase connection.

Biochem J 2014 Dec;464(2):e7-10

*UCL Cancer Institute, Paul O'Gorman Building University College London, 72 Huntley Street, London WC1E 6BT, U.K.

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http://dx.doi.org/10.1042/BJ20141218DOI Listing
December 2014
15 Reads
2 Citations
4.400 Impact Factor

Pancreatic cell plasticity and cancer initiation induced by oncogenic Kras is completely dependent on wild-type PI 3-kinase p110α.

Genes Dev 2014 Dec;28(23):2621-35

UMR1037, Le Centre de Recherches en Cancérologie de Toulouse (CRCT), Inserm, F-31000 Toulouse, France; UMR1037, CRCT, Université Toulouse III-Paul Sabatier, F-31000 Toulouse, France; Equipe Labellisée Ligue Contre le Cancer, F-31000 Toulouse, France;

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http://dx.doi.org/10.1101/gad.249409.114DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4248293PMC
December 2014
50 Reads
20 Citations
10.800 Impact Factor

A new TIPE of phosphoinositide regulator in cancer.

Cancer Cell 2014 Oct;26(4):443-4

UCL Cancer Institute, University College London, 72 Huntley Street, London WC1E 6BT, UK. Electronic address:

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http://dx.doi.org/10.1016/j.ccell.2014.09.017DOI Listing
October 2014
10 Reads
23.523 Impact Factor

Phosphoinositide 3-kinase β mediates microvascular endothelial repair of thrombotic microangiopathy.

Blood 2014 Sep 18;124(13):2142-9. Epub 2014 Aug 18.

Department of Medicine.

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http://dx.doi.org/10.1182/blood-2014-02-557975DOI Listing
September 2014
28 Reads
1 Citation
10.452 Impact Factor

Phosphoinositide 3-kinases p110α and p110β have differential roles in insulin-like growth factor-1-mediated Akt phosphorylation and platelet priming.

Arterioscler Thromb Vasc Biol 2014 Aug 5;34(8):1681-8. Epub 2014 Jun 5.

From the School of Physiology and Pharmacology, University of Bristol, Bristol, United Kingdom (T.A.B., S.F.M., C.M.W., A.W.P., I.H.); and Research Department of Oncology, UCL Cancer Institute, University College London, London, United Kingdom (B.V.).

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http://dx.doi.org/10.1161/ATVBAHA.114.303954DOI Listing
August 2014
46 Reads
6 Citations
6.000 Impact Factor

The phosphoinositide 3-kinase isoform PI3Kβ regulates osteoclast-mediated bone resorption in humans and mice.

Arthritis Rheumatol 2014 Aug;66(8):2210-21

Semmelweis University School of Medicine, and MTA-SE "Lendület" Inflammation Physiology Research Group of the Hungarian Academy of Sciences and Semmelweis University, Budapest, Hungary.

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http://doi.wiley.com/10.1002/art.38660
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http://dx.doi.org/10.1002/art.38660DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4314683PMC
August 2014
24 Reads
4 Citations

Inactivation of PI(3)K p110δ breaks regulatory T-cell-mediated immune tolerance to cancer.

Nature 2014 06 11;510(7505):407-411. Epub 2014 Jun 11.

UCL Cancer Institute, Paul O'Gorman Building, University College London, 72 Huntley Street London WC1E 6DD, UK.

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http://dx.doi.org/10.1038/nature13444DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4501086PMC
June 2014
42 Reads
87 Citations
42.351 Impact Factor

PI3Kδ inhibition hits a sensitive spot in B cell malignancies.

Cancer Cell 2014 Mar;25(3):269-71

UCL Cancer Institute, University College London, 72 Huntley Street, London WC1E 6DD, UK.

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http://dx.doi.org/10.1016/j.ccr.2014.02.012DOI Listing
March 2014
6 Reads
12 Citations
23.523 Impact Factor

Signaling by Fyn-ADAP via the Carma1-Bcl-10-MAP3K7 signalosome exclusively regulates inflammatory cytokine production in NK cells.

Nat Immunol 2013 Nov 15;14(11):1127-36. Epub 2013 Sep 15.

Laboratory of Molecular Immunology and Immunotherapy, Blood Research Institute, Milwaukee, Wisconsin, USA.

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http://dx.doi.org/10.1038/ni.2708DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3855032PMC
November 2013
23 Reads
23 Citations
20.004 Impact Factor

Inhibition of the p110α isoform of PI 3-kinase stimulates nonfunctional tumor angiogenesis.

J Exp Med 2013 Sep 16;210(10):1937-45. Epub 2013 Sep 16.

Vascular Signaling Laboratory; and 2 Translational Research Laboratory, Catalan Institute of Oncology, Institut d'Investigació Biomèdica de Bellvitge (IDIBELL), 08907 L'Hospitalet de Llobregat, Barcelona, Spain.

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http://dx.doi.org/10.1084/jem.20121571DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3782054PMC
September 2013
8 Reads
12 Citations
12.520 Impact Factor

Class III phosphoinositide 3-kinase/VPS34 and dynamin are critical for apical endocytic recycling.

Traffic 2013 Aug 3;14(8):933-48. Epub 2013 Jun 3.

CELL Unit, Université catholique de Louvain & de Duve Institute, Brussels, Belgium.

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http://dx.doi.org/10.1111/tra.12079DOI Listing
August 2013
49 Reads
12 Citations
4.350 Impact Factor

AKT-ing out: SGK kinases come to the fore.

Biochem J 2013 Jun;452(3):e11-3

Centre for Cell Signalling, Barts Cancer Institute, Queen Mary University of London, Charterhouse Square, London EC1M 6BQ, UK.

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http://dx.doi.org/10.1042/BJ20130617DOI Listing
June 2013
16 Reads
6 Citations
4.400 Impact Factor

Long-term p110α PI3K inactivation exerts a beneficial effect on metabolism.

EMBO Mol Med 2013 Apr 11;5(4):563-71. Epub 2013 Mar 11.

Institute of Healthy Ageing and Department of Genetics, Evolution and Environment, University College London, Darwin Building, Gower Street, London, UK.

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http://dx.doi.org/10.1002/emmm.201201953DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3628103PMC
April 2013
6 Reads
17 Citations
8.665 Impact Factor

Polyamine production is downstream and upstream of oncogenic PI3K signalling and contributes to tumour cell growth.

Biochem J 2013 Mar;450(3):619-28

Analytical Signaling Group, Centre for Cell Signaling, Barts Cancer Institute, Queen Mary University of London, Charterhouse Square, London EC1M 6BQ, UK.

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http://dx.doi.org/10.1042/BJ20121525DOI Listing
March 2013
4 Reads
3 Citations
4.400 Impact Factor

Kinase-substrate enrichment analysis provides insights into the heterogeneity of signaling pathway activation in leukemia cells.

Sci Signal 2013 Mar 26;6(268):rs6. Epub 2013 Mar 26.

Analytical Signalling Group, Centre for Cell Signalling, Barts Cancer Institute, Queen Mary University of London, London EC1B 6BQ, UK.

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http://dx.doi.org/10.1126/scisignal.2003573DOI Listing
March 2013
22 Reads
48 Citations
6.280 Impact Factor

The p110δ isoform of the kinase PI(3)K controls the subcellular compartmentalization of TLR4 signaling and protects from endotoxic shock.

Nat Immunol 2012 Nov 30;13(11):1045-1054. Epub 2012 Sep 30.

Centre for Cell Signaling, Barts Institute of Cancer, Queen Mary, University of London, London, UK.

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http://dx.doi.org/10.1038/ni.2426DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4018573PMC
November 2012
20 Reads
54 Citations
20.004 Impact Factor

Developmental defects and rescue from glucose intolerance of a catalytically-inactive novel Ship2 mutant mouse.

Cell Signal 2012 Nov 30;24(11):1971-80. Epub 2012 Jun 30.

Institut de Recherche Interdisciplinaire en Biologie Humaine et Moléculaire (IRIBHM), Institut de Biologie et de Médecine Moléculaires (IBMM), Université Libre de Bruxelles (ULB), Gosselies, Belgium.

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http://dx.doi.org/10.1016/j.cellsig.2012.06.012DOI Listing
November 2012
3 Reads
7 Citations
4.320 Impact Factor

Different PI 3-kinase inhibitors have distinct effects on endothelial permeability and leukocyte transmigration.

Int J Biochem Cell Biol 2012 Nov 17;44(11):1929-36. Epub 2012 Jul 17.

Randall Division of Cell and Molecular Biophysics, King’s College London, New Hunt’s House, Guy’s Campus, London SE1 1UL, UK.

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http://dx.doi.org/10.1016/j.biocel.2012.07.009DOI Listing
November 2012
2 Reads
5 Citations
4.050 Impact Factor

Phosphoproteomic analysis of leukemia cells under basal and drug-treated conditions identifies markers of kinase pathway activation and mechanisms of resistance.

Mol Cell Proteomics 2012 Aug 29;11(8):453-66. Epub 2012 Apr 29.

Analytical Signalling Group, Centre for Cell Signalling, Barts Cancer Institute, Queen Mary University of London, Barts and the London School of Medicine and Dentistry, London EC1M 6BQ, United Kingdom.

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http://dx.doi.org/10.1074/mcp.M112.017483DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3412974PMC
August 2012
64 Reads
23 Citations
6.564 Impact Factor

High levels of p110δ PI3K expression in solid tumor cells suppress PTEN activity, generating cellular sensitivity to p110δ inhibitors through PTEN activation.

FASEB J 2012 Jun 5;26(6):2498-508. Epub 2012 Mar 5.

Department of Biochemistry, School of Medicine, University of Crete, Vassilika Vouton, GR-71110 Heraklion, Greece.

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http://dx.doi.org/10.1096/fj.11-198192DOI Listing
June 2012
9 Reads
15 Citations
5.043 Impact Factor

Attenuation of phosphoinositide 3-kinase δ signaling restrains autoimmune disease.

J Autoimmun 2012 Jun 25;38(4):381-91. Epub 2012 Apr 25.

Leukocyte Signalling Laboratory, Department of Immunology, Alfred Medical Research and Education Precinct, Monash University, Commercial Road, Melbourne, Victoria 3004, Australia.

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http://dx.doi.org/10.1016/j.jaut.2012.04.001DOI Listing
June 2012
9 Reads
12 Citations
8.410 Impact Factor

Isoform-selective induction of human p110δ PI3K expression by TNFα: identification of a new and inducible PIK3CD promoter.

Biochem J 2012 May;443(3):857-67

Centre for Cell Signalling, Barts Cancer Institute, Queen Mary University of London, Charterhouse Square, London EC1M 6BQ, UK.

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http://biochemj.org/lookup/doi/10.1042/BJ20112214
Publisher Site
http://dx.doi.org/10.1042/BJ20112214DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3328000PMC
May 2012
10 Reads
8 Citations
4.400 Impact Factor

Functional CSF-1 receptors are located at the nuclear envelope and activated via the p110δ isoform of PI 3-kinase.

FASEB J 2012 Feb 11;26(2):691-706. Epub 2011 Nov 11.

Department of Biochemistry, School of Medicine, University of Crete, Heraklion, Greece.

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http://dx.doi.org/10.1096/fj.11-189753DOI Listing
February 2012
4 Reads
6 Citations
5.043 Impact Factor

Both p110α and p110β isoforms of PI3K can modulate the impact of loss-of-function of the PTEN tumour suppressor.

Biochem J 2012 Feb;442(1):151-9

Centre for Cell Signalling, Barts Cancer Institute, Queen Mary University of London, Charterhouse Square, London EC1M 6BQ, UK.

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http://dx.doi.org/10.1042/BJ20111741DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3268223PMC
February 2012
11 Reads
26 Citations
4.400 Impact Factor

PI3K signalling: the path to discovery and understanding.

Nat Rev Mol Cell Biol 2012 02 23;13(3):195-203. Epub 2012 Feb 23.

Centre for Cell Signalling, Barts Cancer Institute, Queen Mary University of London, Charterhouse Square, London EC1M 6BQ, United Kingdom.

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http://dx.doi.org/10.1038/nrm3290DOI Listing
February 2012
209 Citations
36.460 Impact Factor

Syndecan-2 is a novel ligand for the protein tyrosine phosphatase receptor CD148.

Mol Biol Cell 2011 Oct 3;22(19):3609-24. Epub 2011 Aug 3.

Centre for Microvascular Research, William Harvey Research Institute, Barts and the London School of Medicine and Dentistry, Queen Mary University of London, London EC1M 6BQ, United Kingdom.

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http://www.molbiolcell.org/content/22/19/3609.full.pdf
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http://www.molbiolcell.org/cgi/doi/10.1091/mbc.E11-02-0099
Publisher Site
http://dx.doi.org/10.1091/mbc.E11-02-0099DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3183016PMC
October 2011
2 Reads
23 Citations
4.470 Impact Factor

Phosphatidylinositol(4,5)bisphosphate coordinates actin-mediated mobilization and translocation of secretory vesicles to the plasma membrane of chromaffin cells.

Nat Commun 2011 Oct 4;2:491. Epub 2011 Oct 4.

The University of Queensland, Queensland Brain Institute and School of Biomedical Sciences, Brisbane, Queensland 4072, Australia.

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http://dx.doi.org/10.1038/ncomms1500DOI Listing
October 2011
6 Reads
23 Citations
10.742 Impact Factor

Calpain interacts with class IA phosphoinositide 3-kinases regulating their stability and signaling activity.

Proc Natl Acad Sci U S A 2011 Sep 19;108(39):16217-22. Epub 2011 Sep 19.

Analytical Signaling Group, Centre for Cell Signaling, Barts Cancer Institute, Queen Mary University of London, Charterhouse Square, London EC1M 6BQ, United Kingdom.

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http://dx.doi.org/10.1073/pnas.1107692108DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3182684PMC
September 2011
3 Reads
5 Citations
9.810 Impact Factor

Activation of the PI3K pathway increases TLR-induced TNF-α and IL-6 but reduces IL-1β production in mast cells.

Cell Signal 2011 May 22;23(5):866-75. Epub 2011 Jan 22.

Department of Biochemistry and Molecular Immunology, Institute of Biochemistry and Molecular Biology, University Clinic, RWTH Aachen University, Aachen, Germany.

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http://dx.doi.org/10.1016/j.cellsig.2011.01.012DOI Listing
May 2011
6 Reads
11 Citations
4.320 Impact Factor

PI3Kδ drives the pathogenesis of experimental autoimmune encephalomyelitis by inhibiting effector T cell apoptosis and promoting Th17 differentiation.

J Autoimmun 2011 May 10;36(3-4):278-87. Epub 2011 Mar 10.

Chemokine Biology Group, School of Molecular & Biomedical Science, University of Adelaide, North Terrace Campus, Adelaide, South Australia 5005, Australia.

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http://dx.doi.org/10.1016/j.jaut.2011.02.006DOI Listing
May 2011
15 Reads
22 Citations
8.410 Impact Factor

PI3K: from the bench to the clinic and back.

Curr Top Microbiol Immunol 2010 ;347:1-19

University of London, London, EC1M 6BQ, UK.

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http://dx.doi.org/10.1007/82_2010_65DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2954281PMC
January 2011
14 Reads
29 Citations
4.100 Impact Factor

Altered macrophage function contributes to colitis in mice defective in the phosphoinositide-3 kinase subunit p110δ.

Gastroenterology 2010 Nov 14;139(5):1642-53, 1653.e1-6. Epub 2010 Jul 14.

Department of Medicine, University of North Carolina School of Medicine, Chapel Hill, North Carolina, USA.

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http://dx.doi.org/10.1053/j.gastro.2010.07.008DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2967619PMC
November 2010
17 Reads
22 Citations
16.720 Impact Factor

A new tool to dissect the function of p70 S6 kinase.

Biochem J 2010 Oct;431(2):e1-3

Centre for Cell Signalling, Institute of Cancer, Queen Mary University of London, Charterhouse Square, London, UK.

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http://www.biochemj.org/content/ppbiochemj/431/2/e1.full.pdf
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http://biochemj.org/lookup/doi/10.1042/BJ20101445
Publisher Site
http://dx.doi.org/10.1042/BJ20101445DOI Listing
October 2010
17 Reads
3 Citations
4.400 Impact Factor

Phosphoinositide 3-kinase δ regulates membrane fission of Golgi carriers for selective cytokine secretion.

J Cell Biol 2010 Sep 13;190(6):1053-65. Epub 2010 Sep 13.

Institute for Molecular Bioscience, University of Queensland, Brisbane, Queensland 4072, Australia.

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http://dx.doi.org/10.1083/jcb.201001028DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3101599PMC
September 2010
10 Reads
18 Citations
9.834 Impact Factor

The PI3K isoforms p110alpha and p110delta are essential for pre-B cell receptor signaling and B cell development.

Sci Signal 2010 Aug 10;3(134):ra60. Epub 2010 Aug 10.

1Laboratory of Lymphocyte Signalling and Development, Babraham Institute, Cambridge CB22 3AT, UK.

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http://dx.doi.org/10.1126/scisignal.2001104DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3540743PMC
August 2010
5 Reads
56 Citations
6.280 Impact Factor

Btk-dependent Rac activation and actin rearrangement following FcepsilonRI aggregation promotes enhanced chemotactic responses of mast cells.

J Cell Sci 2010 Aug 29;123(Pt 15):2576-85. Epub 2010 Jun 29.

Laboratory of Allergic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, 10 Center Drive MSC 1881, Bethesda, MD 20892-1881, USA.

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http://dx.doi.org/10.1242/jcs.071043DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2908047PMC
August 2010
24 Reads
22 Citations
5.432 Impact Factor

Activity of any class IA PI3K isoform can sustain cell proliferation and survival.

Proc Natl Acad Sci U S A 2010 Jun 7;107(25):11381-6. Epub 2010 Jun 7.

Centre for Cell Signalling, Institute of Cancer, Queen Mary University of London, London EC1M 6BQ, United Kingdom.

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http://dx.doi.org/10.1073/pnas.0906461107DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2895061PMC
June 2010
20 Reads
47 Citations
9.810 Impact Factor

The emerging mechanisms of isoform-specific PI3K signalling.

Nat Rev Mol Cell Biol 2010 May 9;11(5):329-41. Epub 2010 Apr 9.

Centre for Cell Signalling, Institute of Cancer, Queen Mary University of London, Charterhouse Square, London, UK.

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http://dx.doi.org/10.1038/nrm2882DOI Listing
May 2010
18 Reads
387 Citations
36.460 Impact Factor

The PI3K p110alpha isoform regulates endothelial adherens junctions via Pyk2 and Rac1.

J Cell Biol 2010 Mar;188(6):863-76

Randall Division of Cell and Molecular Biophysics, King's College London, London SE1 1UL, England, UK.

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http://dx.doi.org/10.1083/jcb.200907135DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2845076PMC
March 2010
21 Reads
43 Citations
9.834 Impact Factor

Deletion of the p110beta isoform of phosphoinositide 3-kinase in platelets reveals its central role in Akt activation and thrombus formation in vitro and in vivo.

Blood 2010 Mar 11;115(10):2008-13. Epub 2010 Jan 11.

Inserm, U563, Centre de Physiopathologie de Toulouse Purpan, Département d'Oncogenèse, Signalisation et Innovation thérapeutique, and Université Toulouse III Paul-Sabatier, Toulouse, France.

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http://dx.doi.org/10.1182/blood-2009-04-217224DOI Listing
March 2010
19 Reads
28 Citations
10.452 Impact Factor

PI3K regulatory subunits lose control in cancer.

Cancer Cell 2009 Dec;16(6):449-50

Centre for Cell Signalling, Institute of Cancer, Queen Mary University of London, Charterhouse Square, London EC1M 6BQ, UK.

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http://dx.doi.org/10.1016/j.ccr.2009.11.017DOI Listing
December 2009
12 Reads
9 Citations
23.523 Impact Factor

Phosphoinositide 3-kinase p110 delta regulates natural antibody production, marginal zone and B-1 B cell function, and autoantibody responses.

J Immunol 2009 Nov;183(9):5673-84

Department of Microbiology and Immunology, Infection, Inflammation, and Immunity (I(3)) and CELL Research Groups, Life Sciences Institute, University of British Columbia, Vancouver, British Columbia, Canada.

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http://dx.doi.org/10.4049/jimmunol.0900432DOI Listing
November 2009
19 Reads
42 Citations
4.922 Impact Factor

Regulation of p110delta PI 3-kinase gene expression.

PLoS One 2009 9;4(4):e5145. Epub 2009 Apr 9.

Centre for Cell Signalling, Institute of Cancer, Queen Mary University of London, Charterhouse Square, London, United Kingdom.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0005145PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2663053PMC
October 2009
4 Reads
17 Citations
3.234 Impact Factor

The p110delta isoform of phosphatidylinositol 3-kinase controls susceptibility to Leishmania major by regulating expansion and tissue homing of regulatory T cells.

J Immunol 2009 Aug 13;183(3):1921-33. Epub 2009 Jul 13.

Department of Immunology, University of Manitoba, Winnipeg, Manitoba, Canada.

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http://dx.doi.org/10.4049/jimmunol.0901099DOI Listing
August 2009
20 Reads
31 Citations
4.922 Impact Factor

CCL21 mediates CD4+ T-cell costimulation via a DOCK2/Rac-dependent pathway.

Blood 2009 Jul 18;114(3):580-8. Epub 2009 May 18.

Theodor Kocher Institute, University of Bern, Freiestrasse 1, Bern, Switzerland.

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http://dx.doi.org/10.1182/blood-2009-01-200923DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2713469PMC
July 2009
5 Reads
18 Citations
10.452 Impact Factor

Regulation of phosphoinositide 3-kinase expression in health and disease.

Trends Biochem Sci 2009 Mar 18;34(3):115-27. Epub 2009 Mar 18.

Centre for Cell Signalling, Institute of Cancer, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, Charterhouse Square, London EC1 M 6BQ, UK.

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http://dx.doi.org/10.1016/j.tibs.2009.01.003DOI Listing
March 2009
2 Reads
63 Citations
11.230 Impact Factor

Inhibition of class I phosphoinositide 3-kinase activity impairs proliferation and triggers apoptosis in acute promyelocytic leukemia without affecting atra-induced differentiation.

Cancer Res 2009 Feb 27;69(3):1027-36. Epub 2009 Jan 27.

Centre for Cell Signalling, Queen Mary University of London, Institute of Cancer, Barts and The London School of Medicine, John Vane Science Centre University College London, London, United Kingdom.

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http://dx.doi.org/10.1158/0008-5472.CAN-08-2608DOI Listing
February 2009
4 Reads
20 Citations
9.330 Impact Factor

Distinct roles of class IA PI3K isoforms in primary and immortalised macrophages.

J Cell Sci 2008 Dec 25;121(Pt 24):4124-33. Epub 2008 Nov 25.

Centre for Cell Signalling, Institute of Cancer, Queen Mary, University of London, Charterhouse Square, London EC1M 6BQ, UK.

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http://dx.doi.org/10.1242/jcs.032763DOI Listing
December 2008
7 Reads
37 Citations
5.432 Impact Factor

Killing two kinase families with one stone.

Nat Chem Biol 2008 Nov;4(11):648-9

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http://dx.doi.org/10.1038/nchembio1108-648DOI Listing
November 2008
3 Reads
8 Citations
13.000 Impact Factor

Genetic or pharmaceutical blockade of p110delta phosphoinositide 3-kinase enhances IgE production.

J Allergy Clin Immunol 2008 Oct;122(4):811-819.e2

CIHR National Training Program in Allergy and Asthma Research, University of Manitoba, Winnipeg, Manitoba, Canada; Department of Immunology, University of Manitoba, Winnipeg, Manitoba, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.jaci.2008.08.008DOI Listing
October 2008
14 Reads
19 Citations
11.480 Impact Factor

The p110 delta of PI3K plays a critical role in NK cell terminal maturation and cytokine/chemokine generation.

J Exp Med 2008 Sep 22;205(10):2419-35. Epub 2008 Sep 22.

Laboratory of Molecular Immunology, Blood Research Institute, Medical College of Wisconsin, Milwaukee, WI 53226, USA.

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http://dx.doi.org/10.1084/jem.20072327DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2556795PMC
September 2008
9 Reads
39 Citations
12.520 Impact Factor

The p110beta isoform of phosphoinositide 3-kinase signals downstream of G protein-coupled receptors and is functionally redundant with p110gamma.

Proc Natl Acad Sci U S A 2008 Jun 10;105(24):8292-7. Epub 2008 Jun 10.

Center for Cell Signaling, Institute of Cancer, Queen Mary University of London, Charterhouse Square, London EC1M 6BQ, United Kingdom.

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http://dx.doi.org/10.1073/pnas.0707761105DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2448830PMC
June 2008
13 Reads
134 Citations
9.810 Impact Factor

Angiogenesis selectively requires the p110alpha isoform of PI3K to control endothelial cell migration.

Nature 2008 May 30;453(7195):662-6. Epub 2008 Apr 30.

Centre for Cell Signalling, Institute of Cancer, Queen Mary, University of London, Charterhouse Square, London EC1M 6BQ, UK.

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http://dx.doi.org/10.1038/nature06892DOI Listing
May 2008
25 Reads
140 Citations
42.351 Impact Factor

Activation of c-Kit in dendritic cells regulates T helper cell differentiation and allergic asthma.

Nat Med 2008 May 4;14(5):565-73. Epub 2008 May 4.

Division of Pulmonary, Allergy and Critical Care Medicine, Department of Medicine, University of Pittsburgh School of Medicine, 3459 Fifth Avenue, Pittsburgh, Pennsylvania 15213, USA.

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http://dx.doi.org/10.1038/nm1766DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3664066PMC
May 2008
2 Reads
64 Citations
27.363 Impact Factor

Activation of phosphoinositide 3-kinase by the NBS1 DNA repair protein through a novel activation motif.

J Mol Med (Berl) 2008 Apr 13;86(4):401-12. Epub 2008 Feb 13.

Institute of Biochemistry and Molecular Biology, National Yang-Ming University, No.155, Li-Nong St., Sec.2, Peitou, Taipei 112, Taiwan.

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http://dx.doi.org/10.1007/s00109-008-0302-xDOI Listing
April 2008
40 Reads
10 Citations
5.110 Impact Factor

Isoform-specific functions of phosphoinositide 3-kinases: p110 delta but not p110 gamma promotes optimal allergic responses in vivo.

J Immunol 2008 Feb;180(4):2538-44

Centre for Cell Signalling, Institute of Cancer, Queen Mary University of London, Sir John Vane Research Centre, Charterhouse Square, London, United Kingdom.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2643005PMC
http://dx.doi.org/10.4049/jimmunol.180.4.2538DOI Listing
February 2008
5 Reads
34 Citations
4.922 Impact Factor

Quantitative profile of five murine core proteomes using label-free functional proteomics.

Mol Cell Proteomics 2007 Sep 12;6(9):1560-73. Epub 2007 Jun 12.

Cell Signalling Group, Ludwig Institute for Cancer Research, London, UK.

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http://dx.doi.org/10.1074/mcp.M700037-MCP200DOI Listing
September 2007
3 Reads
35 Citations
6.564 Impact Factor

The p110delta isoform of PI 3-kinase negatively controls RhoA and PTEN.

EMBO J 2007 Jul 21;26(13):3050-61. Epub 2007 Jun 21.

Ludwig Institute for Cancer Research, London, UK.

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http://dx.doi.org/10.1038/sj.emboj.7601763DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1914109PMC
July 2007
47 Citations
10.434 Impact Factor

Class IA phosphoinositide 3-kinases are obligate p85-p110 heterodimers.

Proc Natl Acad Sci U S A 2007 May 30;104(19):7809-14. Epub 2007 Apr 30.

Ludwig Institute for Cancer Research, 91 Riding House Street, London W1W 7BS, United Kingdom.

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http://dx.doi.org/10.1073/pnas.0700373104DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1876529PMC
May 2007
5 Reads
75 Citations
9.810 Impact Factor

The Pten/PI3K pathway governs the homeostasis of Valpha14iNKT cells.

Blood 2007 Apr 14;109(8):3316-24. Epub 2006 Dec 14.

Department of Molecular Biology, Akita University School of Medicine, Hondo 1-1-1, Akita 0108-543, Japan.

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http://dx.doi.org/10.1182/blood-2006-07-038059DOI Listing
April 2007
22 Reads
23 Citations
10.452 Impact Factor

Antigen receptor signalling: a distinctive role for the p110delta isoform of PI3K.

Trends Immunol 2007 Feb 5;28(2):80-7. Epub 2007 Jan 5.

Laboratory of Lymphocyte Signalling and Development, Babraham Institute, Cambridge, UK, CB2 4AT.

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http://dx.doi.org/10.1016/j.it.2006.12.007DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2358943PMC
February 2007
7 Reads
41 Citations
10.400 Impact Factor

Role of the phosphoinositide 3-kinase p110delta in generation of type 2 cytokine responses and allergic airway inflammation.

Eur J Immunol 2007 Feb;37(2):416-24

CIHR National Training Program in Allergy and Asthma Research and Department of Immunology, University of Manitoba, Winnipeg, Canada.

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http://dx.doi.org/10.1002/eji.200636401DOI Listing
February 2007
8 Reads
36 Citations
4.034 Impact Factor

Requirement for phosphoinositide 3-kinase p110delta signaling in B cell antigen receptor-mediated antigen presentation.

J Immunol 2007 Feb;178(4):2328-35

Department of Immunology, University of Manitoba, Winnipeg, Canada.

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http://dx.doi.org/10.4049/jimmunol.178.4.2328DOI Listing
February 2007
12 Reads
10 Citations
4.922 Impact Factor

Cutting edge: the phosphoinositide 3-kinase p110 delta is critical for the function of CD4+CD25+Foxp3+ regulatory T cells.

J Immunol 2006 Nov;177(10):6598-602

Laboratory of Lymphocyte Signalling and Development, Babraham Institute, Cambridge, United Kingdom.

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http://dx.doi.org/10.4049/jimmunol.177.10.6598DOI Listing
November 2006
14 Reads
84 Citations
4.922 Impact Factor

Charging the batteries to heal wounds through PI3K.

Nat Chem Biol 2006 Sep;2(9):453-5

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http://dx.doi.org/10.1038/nchembio0906-453DOI Listing
September 2006
8 Citations
13.000 Impact Factor

Ultrasensitive and absolute quantification of the phosphoinositide 3-kinase/Akt signal transduction pathway by mass spectrometry.

Proc Natl Acad Sci U S A 2006 Jun 2;103(24):8959-64. Epub 2006 Jun 2.

Cell Signaling in Cancer Laboratory, Ludwig Institute for Cancer Research, 91 Riding House Street, London W1W 7BS, United Kingdom.

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http://dx.doi.org/10.1073/pnas.0602101103DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1482548PMC
June 2006
6 Reads
9 Citations
9.810 Impact Factor

Critical role for the p110alpha phosphoinositide-3-OH kinase in growth and metabolic regulation.

Nature 2006 May 12;441(7091):366-70. Epub 2006 Apr 12.

Ludwig Institute for Cancer Research, 91 Riding House Street, London W1W 7BS, UK.

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http://dx.doi.org/10.1038/nature04694DOI Listing
May 2006
24 Reads
156 Citations
42.351 Impact Factor

Oncogenic transformation induced by the p110beta, -gamma, and -delta isoforms of class I phosphoinositide 3-kinase.

Proc Natl Acad Sci U S A 2006 Jan 23;103(5):1289-94. Epub 2006 Jan 23.

Department of Molecular and Experimental Medicine, The Scripps Research Institute, 10550 North Torrey Pines Road, BCC 239, La Jolla, CA 92037, USA.

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http://dx.doi.org/10.1073/pnas.0510772103DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1360601PMC
January 2006
14 Reads
89 Citations
9.810 Impact Factor

Key role of the p110delta isoform of PI3K in B-cell antigen and IL-4 receptor signaling: comparative analysis of genetic and pharmacologic interference with p110delta function in B cells.

Blood 2006 Jan 22;107(2):642-50. Epub 2005 Sep 22.

Ludwig Institute for Cancer Research, 91 Riding House Street, London, W1W 7BS, United Kingdom.

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http://dx.doi.org/10.1182/blood-2005-07-3041DOI Listing
January 2006
5 Reads
62 Citations
10.452 Impact Factor

Role of the p110delta PI 3-kinase in integrin and ITAM receptor signalling in platelets.

Platelets 2005 May-Jun;16(3-4):191-202

Centre for Cardiovascular Sciences, Division of Medical Sciences, Institute of Biomedical Research, Wolfson Drive, The Medical School, University of Birmingham, Edgbaston, Birmingham, UK.

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http://dx.doi.org/10.1080/09537100400016711DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1868960PMC
October 2005
28 Reads
6 Citations
2.630 Impact Factor

Quantification of gel-separated proteins and their phosphorylation sites by LC-MS using unlabeled internal standards: analysis of phosphoprotein dynamics in a B cell lymphoma cell line.

Mol Cell Proteomics 2005 Aug 5;4(8):1038-51. Epub 2005 May 5.

Cell Signalling Group, Ludwig Institute for Cancer Research, 91 Riding House Street, London, W1W 7BS.

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http://dx.doi.org/10.1074/mcp.M500078-MCP200DOI Listing
August 2005
31 Reads
22 Citations
6.564 Impact Factor

Signalling by PI3K isoforms: insights from gene-targeted mice.

Trends Biochem Sci 2005 Apr;30(4):194-204

Ludwig Institute for Cancer Research, 91 Riding House Street, London W1W 7BS, UK.

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http://dx.doi.org/10.1016/j.tibs.2005.02.008DOI Listing
April 2005
5 Reads
138 Citations
11.230 Impact Factor