Publications by authors named "Bart Staels"

100Publications

A blood-based biomarker panel (NIS4) for non-invasive diagnosis of non-alcoholic steatohepatitis and liver fibrosis: a prospective derivation and global validation study.

Authors:
Stephen A Harrison Vlad Ratziu Jérôme Boursier Sven Francque Pierre Bedossa Zouher Majd Geneviève Cordonnier Fouad Ben Sudrik Raphael Darteil Roman Liebe Jérémy Magnanensi Yacine Hajji John Brozek Alice Roudot Bart Staels Dean W Hum Sophie Jeannin Megnien Suneil Hosmane Noémie Dam Pierre Chaumat Rémy Hanf Quentin M Anstee Arun J Sanyal

Lancet Gastroenterol Hepatol 2020 Aug 4. Epub 2020 Aug 4.

Department of Internal Medicine, Virginia Commonwealth University School of Medicine, Richmond, VA, USA.

View Article

Download full-text PDF

 Source
http://dx.doi.org/10.1016/S2468-1253(20)30252-1DOI Listing
August 2020

Author Correction: Transcriptional network analysis implicates altered hepatic immune function in NASH development and resolution.

Authors:
Joel T Haas Luisa Vonghia Denis A Mogilenko An Verrijken Olivier Molendi-Coste Sébastien Fleury Audrey Deprince Artemii Nikitin Eloïse Woitrain Lucie Ducrocq-Geoffroy Samuel Pic Bruno Derudas Hélène Dehondt Céline Gheeraert Luc Van Gaal Ann Driessen Philippe Lefebvre Bart Staels Sven Francque David Dombrowicz

Nat Metab 2019 Jul;1(7):744

University of Lille, Inserm, CHU Lille, Institut Pasteur de Lille, U1011-EGID, Lille, France.

View Article

Download full-text PDF

 Source
http://dx.doi.org/10.1038/s42255-019-0093-0DOI Listing
July 2019

Endoplasmic reticulum stress actively suppresses hepatic molecular identity in damaged liver.

Authors:
Vanessa Dubois Céline Gheeraert Wouter Vankrunkelsven Julie Dubois-Chevalier Hélène Dehondt Marie Bobowski-Gerard Manjula Vinod Francesco Paolo Zummo Fabian Güiza Maheul Ploton Emilie Dorchies Laurent Pineau Alexis Boulinguiez Emmanuelle Vallez Eloise Woitrain Eric Baugé Fanny Lalloyer Christian Duhem Nabil Rabhi Ronald E van Kesteren Cheng-Ming Chiang Steve Lancel Hélène Duez Jean-Sébastien Annicotte Réjane Paumelle Ilse Vanhorebeek Greet Van den Berghe Bart Staels Philippe Lefebvre Jérôme Eeckhoute

Mol Syst Biol 2020 05;16(5):e9156

Inserm, CHU Lille, Institut Pasteur de Lille, U1011-EGID, University of Lille, Lille, France.

View Article

Download full-text PDF

 Source
http://dx.doi.org/10.15252/msb.20199156DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7224309PMC
May 2020

Deletion of fibroblast activation protein provides atheroprotection.

Authors:
Sokrates Stein Julien Weber Stefanie Nusser-Stein Jürgen Pahla Hui E Zhang Shafeeq A Mohammed Sara Oppi Daniel S Gaul Francesco Paneni Anne Tailleux Bart Staels Ferdinand von Meyenn Frank Ruschitzka Mark D Gorrell Thomas F Lüscher Christian M Matter

Cardiovasc Res 2020 May 13. Epub 2020 May 13.

Center for Molecular Cardiology, University of Zurich, CH-8952 Schlieren, Switzerland.

View Article

Download full-text PDF

 Source
http://dx.doi.org/10.1093/cvr/cvaa142DOI Listing
May 2020

Perspectives on the use of super-enhancers as a defining feature of cell/tissue-identity genes.

Authors:
Julie Dubois-Chevalier Vanessa Dubois Bart Staels Philippe Lefebvre Jérôme Eeckhoute

Epigenomics 2020 Apr 12;12(8):715-723. Epub 2020 May 12.

University of Lille, Inserm, CHU Lille, Institut Pasteur de Lille, U1011-EGID, Lille F-59000 Lille, France.

View Article

Download full-text PDF

 Source
http://dx.doi.org/10.2217/epi-2019-0290DOI Listing
April 2020

Hepatic molecular signatures highlight the sexual dimorphism of Non-Alcoholic SteatoHepatitis (NASH).

Authors:
Jimmy Vandel Julie Dubois-Chevalier Céline Gheeraert Bruno Derudas Violetta Raverdy Dorothée Thuillier Luc Van Gaal Sven Francque François Pattou Bart Staels Jérôme Eeckhoute Philippe Lefebvre

Hepatology 2020 May 11. Epub 2020 May 11.

Univ. Lille, Inserm, CHU Lille, Institut Pasteur de Lille, U1011-EGID, Lille, France.

View Article

Download full-text PDF

 Source
http://dx.doi.org/10.1002/hep.31312DOI Listing
May 2020

Hepatic saturated fatty acid fraction is associated with de novo lipogenesis and hepatic insulin resistance.

Authors:
Kay H M Roumans Lucas Lindeboom Pandichelvam Veeraiah Carlijn M E Remie Esther Phielix Bas Havekes Yvonne M H Bruls Martijn C G J Brouwers Marcus Ståhlman Marjan Alssema Harry P F Peters Renée de Mutsert Bart Staels Marja-Riitta Taskinen Jan Borén Patrick Schrauwen Vera B Schrauwen-Hinderling

Nat Commun 2020 04 20;11(1):1891. Epub 2020 Apr 20.

Department of Nutrition and Movement Sciences, Maastricht University, P.O. BOX 616, 6200 MD, Maastricht, The Netherlands.

View Article

Download full-text PDF

 Source
http://dx.doi.org/10.1038/s41467-020-15684-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7170906PMC
April 2020

Plasma BCAA Changes in Patients With NAFLD Are Sex Dependent.

Authors:
Guillaume Grzych Luisa Vonghia Marie-Adélaïde Bout Jonas Weyler An Verrijken Eveline Dirinck Marie Joncquel Chevalier Curt Luc Van Gaal Réjane Paumelle Sven Francque Anne Tailleux Joel T Haas Bart Staels

J Clin Endocrinol Metab 2020 Jul;105(7)

University of Lille, Inserm, CHU Lille, Institut Pasteur de Lille, U1011-EGID, Lille, France.

View Article

Download full-text PDF

 Source
http://dx.doi.org/10.1210/clinem/dgaa175DOI Listing
July 2020

Cross-omics analysis revealed gut microbiome-related metabolic pathways underlying atherosclerosis development after antibiotics treatment.

Authors:
Ben Arpad Kappel Lorenzo De Angelis Michael Heiser Marta Ballanti Robert Stoehr Claudia Goettsch Maria Mavilio Anna Artati Omero A Paoluzi Jerzy Adamski Geltrude Mingrone Bart Staels Remy Burcelin Giovanni Monteleone Rossella Menghini Nikolaus Marx Massimo Federici

Mol Metab 2020 Jun 13;36:100976. Epub 2020 Mar 13.

Department of Systems Medicine, University of Rome Tor Vergata, Rome, Italy; Center for Atherosclerosis, Policlinico Tor Vergata, Rome, Italy. Electronic address:

View Article

Download full-text PDF

 Source
http://dx.doi.org/10.1016/j.molmet.2020.100976DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7183232PMC
June 2020

Electrothermal patches driving the transdermal delivery of insulin.

Authors:
Quentin Pagneux Ran Ye Li Chengnan Alexandre Barras Nathalie Hennuyer Bart Staels D Caina J I Avila Osses Amar Abderrahmani Valérie Plaisance Valérie Pawlowski Rabah Boukherroub Sorin Melinte Sabine Szunerits

Nanoscale Horiz 2020 Apr 2;5(4):663-670. Epub 2020 Jan 2.

Univ. Lille, CNRS, Centrale Lille, Yncréa ISEN, Univ. Polytechnique Hauts-de-France, UMR 8520 - IEMN, F-59000 Lille, France.

View Article

Download full-text PDF

 Source
http://dx.doi.org/10.1039/c9nh00576eDOI Listing
April 2020

Incretin combination therapy for the treatment of non-alcoholic steatohepatitis.

Authors:
Aimo Kannt Andreas Nygaard Madsen Claire Kammermeier Ralf Elvert Tim Klöckener Martin Bossart Torsten Haack Andreas Evers Katrin Lorenz Wolfgang Hennerici Corinne Rocher Zsolt Böcskei Jean-Claude Guillemot Vincent Mikol Francois Pattou Bart Staels Michael Wagner

Diabetes Obes Metab 2020 Aug 12;22(8):1328-1338. Epub 2020 Apr 12.

Sanofi Research and Development, Frankfurt, Germany.

View Article

Download full-text PDF

 Source
http://dx.doi.org/10.1111/dom.14035DOI Listing
August 2020

Pirfenidone Is an Agonistic Ligand for PPARα and Improves NASH by Activation of SIRT1/LKB1/pAMPK.

Authors:
Ana Sandoval-Rodriguez Hugo Christian Monroy-Ramirez Alejandra Meza-Rios Jesus Garcia-Bañuelos Jose Vera-Cruz Jorge Gutiérrez-Cuevas Jorge Silva-Gomez Bart Staels Jose Dominguez-Rosales Marina Galicia-Moreno Monica Vazquez-Del Mercado Jose Navarro-Partida Arturo Santos-Garcia Juan Armendariz-Borunda

Hepatol Commun 2020 Mar 16;4(3):434-449. Epub 2020 Jan 16.

Department of Molecular Biology and Genomics Institute for Molecular Biology in Medicine and Gene Therapy Health Sciences University Center University of Guadalajara Guadalajara México.

View Article

Download full-text PDF

 Source
http://dx.doi.org/10.1002/hep4.1474DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7049672PMC
March 2020

Microbiome Modulation of the Host Adaptive Immunity through Bile Acid Modification.

Authors:
Folkert Kuipers Jan Freark de Boer Bart Staels

Cell Metab 2020 Mar;31(3):445-447

Univ. Lille, Inserm, CHU Lille, Institut Pasteur de Lille, U1011- EGID, 59000 Lille, France.

View Article

Download full-text PDF

 Source
http://dx.doi.org/10.1016/j.cmet.2020.02.006DOI Listing
March 2020

Analysis of the association of MPO and MMP-9 with stroke severity and outcome: Cohort study.

Authors:
Ilaria Maestrini Madjid Tagzirt Sophie Gautier Annabelle Dupont Anne-Marie Mendyk Sophie Susen Anne Tailleux Emmanuelle Vallez Bart Staels Charlotte Cordonnier Didier Leys Regis Bordet

Neurology 2020 Jul 28;95(1):e97-e108. Epub 2020 Feb 28.

From the Departments of Neurology (I.M., A.-M.M., C.C., D.L.) and Medical Pharmacology (S.G., R.B.), Degenerative and Vascular Cognitive Disorders, University Hospital CHU Lille, Inserm U1171, University of Lille, France; Department of Human Neurosciences (I.M.), "Sapienza" University of Rome, Italy; and European Genomic Institute for Diabetes (M.T., A.D., S.S., A.T., E.V., B.S.), University Hospital CHU Lille, Inserm U1011, Institut Pasteur of Lille, University of Lille, France.

View Article

Download full-text PDF

 Source
http://dx.doi.org/10.1212/WNL.0000000000009179DOI Listing
July 2020

Differential unfolded protein response in skeletal muscle from non-diabetic glucose tolerant or intolerant patients with obesity before and after bariatric surgery.

Authors:
Camille Marciniak Christian Duhem Alexis Boulinguiez Violeta Raverdy Gregory Baud Hélène Verkindt Robert Caiazzo Bart Staels Hélène Duez François Pattou Steve Lancel

Acta Diabetol 2020 Jul 21;57(7):819-826. Epub 2020 Feb 21.

Univ. Lille, Inserm, CHU Lille, Institut Pasteur de Lille, U1011 - EGID, F-59000, Lille, France.

View Article

Download full-text PDF

 Source
http://dx.doi.org/10.1007/s00592-020-01490-zDOI Listing
July 2020

Clinical significance of electrocardiographic markers of myocardial damage prior to aortic valve replacement.

Authors:
Augustin Coisne Sandro Ninni François Pontana Samy Aghezzaf Florent Janvier Stéphanie Mouton Hélène Ridon Staniel Ortmans Claire Seunes Marine Wautier Amandine Coppin Anne-Laure Madika Bertrand Boutie Mohamad Koussa Antoine Bical André Vincentelli Francis Juthier Valentin Loobuyck Arnaud Sudre Stella Marchetta Christophe Martinez Bart Staels Patrizio Lancellotti Thomas Modine David Montaigne

Int J Cardiol 2020 May 29;307:130-135. Epub 2020 Jan 29.

CHU Lille, Department of Clinical Physiology and Echocardiography, France; Univ. Lille, U1011 - EGID, F-59000 Lille, France; Inserm, U1011, F-59000 Lille, France; Institut Pasteur de Lille, F-59000 Lille, France.

View Article

Download full-text PDF

 Source
http://dx.doi.org/10.1016/j.ijcard.2020.01.073DOI Listing
May 2020

Sirt6 deletion in bone marrow-derived cells increases atherosclerosis - Central role of macrophage scavenger receptor 1.

Authors:
Tasneem Arsiwala Jürgen Pahla Lambertus J van Tits Lavinia Bisceglie Daniel S Gaul Sarah Costantino Melroy X Miranda Kathrin Nussbaum Simona Stivala Przemyslaw Blyszczuk Julien Weber Anne Tailleux Sokrates Stein Francesco Paneni Jürg H Beer Melanie Greter Burkhard Becher Raul Mostoslavsky Urs Eriksson Bart Staels Johan Auwerx Michael O Hottiger Thomas F Lüscher Christian M Matter

J Mol Cell Cardiol 2020 02 21;139:24-32. Epub 2020 Jan 21.

Center for Molecular Cardiology, University of Zurich, Zurich, Switzerland; Department of Cardiology, University Heart Center, Zurich University Hospital, Zurich, Switzerland. Electronic address:

View Article

Download full-text PDF

 Source
http://dx.doi.org/10.1016/j.yjmcc.2020.01.002DOI Listing
February 2020

Effect of 6-Benzoyl-benzothiazol-2-one scaffold on the pharmacological profile of α-alkoxyphenylpropionic acid derived PPAR agonists.

Authors:
Aurélie Hurtevent Morgan Le Naour Veronique Leclerc Pascal Carato Patricia Melnyk Nathalie Hennuyer Bart Staels Monique Beucher-Gaudin Daniel-Henri Caignard Catherine Dacquet Nicolas Lebegue

J Enzyme Inhib Med Chem 2020 Dec;35(1):524-538

Univ. Lille, Inserm, CHU Lille, UMR-S 1172 - JPArc - Centre de Recherche Jean-Pierre AUBERT Neurosciences et Cancer, Lille, France.

View Article

Download full-text PDF

 Source
http://dx.doi.org/10.1080/14756366.2020.1713771DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7006651PMC
December 2020

The nuclear receptor FXR inhibits Glucagon-Like Peptide-1 secretion in response to microbiota-derived Short-Chain Fatty Acids.

Authors:
Sarah Ducastel Véronique Touche Mohamed-Sami Trabelsi Alexis Boulinguiez Laura Butruille Margaux Nawrot Simon Peschard Oscar Chávez-Talavera Emilie Dorchies Emmanuelle Vallez Jean-Sébastien Annicotte Steve Lancel Olivier Briand Kadiombo Bantubungi Sandrine Caron Laure B Bindels Nathalie M Delzenne Anne Tailleux Bart Staels Sophie Lestavel

Sci Rep 2020 01 13;10(1):174. Epub 2020 Jan 13.

Université de Lille, Inserm, CHU Lille, Institut Pasteur de Lille, U1011- EGID, F-59000, Lille, France.

View Article

Download full-text PDF

 Source
http://dx.doi.org/10.1038/s41598-019-56743-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6957696PMC
January 2020

Interindividual Heterogeneity of SGLT2 Expression and Function in Human Pancreatic Islets.

Authors:
Chiara Saponaro Markus Mühlemann Ana Acosta-Montalvo Anthony Piron Valery Gmyr Nathalie Delalleau Ericka Moerman Julien Thévenet Gianni Pasquetti Anais Coddeville Miriam Cnop Julie Kerr-Conte Bart Staels François Pattou Caroline Bonner

Diabetes 2020 May 2;69(5):902-914. Epub 2020 Jan 2.

INSERM, U1190, Lille, France

View Article

Download full-text PDF

 Source
http://dx.doi.org/10.2337/db19-0888DOI Listing
May 2020

Bile acids associate with glucose metabolism, but do not predict conversion from impaired fasting glucose to diabetes.

Authors:
Oscar Chávez-Talavera Matthieu Wargny Matthieu Pichelin Amandine Descat Emmanuelle Vallez Mostafa Kouach Edith Bigot-Corbel Marielle Joliveau Jean-François Goossens Cédric Le May Samy Hadjadj Rémy Hanf Anne Tailleux Bart Staels Bertrand Cariou

Metabolism 2020 02 27;103:154042. Epub 2019 Nov 27.

L'institut du thorax, Department of Endocrinology, CIC 1413 INSERM, CHU Nantes, Nantes, France; L'institut du thorax, INSERM, CNRS, Univ. Nantes, CHU Nantes, Nantes, France. Electronic address:

View Article

Download full-text PDF

 Source
http://dx.doi.org/10.1016/j.metabol.2019.154042DOI Listing
February 2020

Synthesis of benzopyran derivatives as PPARα and/or PPARγ activators.

Authors:
Almudena Bermejo Isabel Barrachina Noureddine El Aouad Xavier Franck Nadia Chahboune Inmaculada Andreu Bruno Figadère Laura Vila Nathalie Hennuyer Bart Staels Catherine Dacquet Daniel H Caignard María-Jesús Sanz Diego Cortes Nuria Cabedo

Bioorg Med Chem 2019 12 30;27(24):115162. Epub 2019 Oct 30.

Departamento de Farmacología, Universidad de Valencia, Valencia, Spain; Instituto de Investigación Sanitaria - INCLIVA, Hospital Clínico Universitario de Valencia, Valencia 46010, Spain. Electronic address:

View Article

Download full-text PDF

 Source
http://dx.doi.org/10.1016/j.bmc.2019.115162DOI Listing
December 2019

Transcriptional Network Analysis Implicates Altered Hepatic Immune Function in NASH development and resolution.

Authors:
Joel T Haas Luisa Vonghia Denis A Mogilenko An Verrijken Olivier Molendi-Coste Sébastien Fleury Audrey Deprince Artemii Nikitin Eloïse Woitrain Lucie Ducrocq-Geoffroy Samuel Pic Bruno Derudas Hélène Dehondt Céline Gheeraert Luc Van Gaal Ann Driessen Philippe Lefebvre Bart Staels Sven Francque David Dombrowicz

Nat Metab 2019 Jun 14;1(6):604-614. Epub 2019 Jun 14.

University of Lille, EGID, Inserm, CHU Lille, Institut Pasteur de Lille, U1011, Lille, France.

View Article

Download full-text PDF

 Source
http://dx.doi.org/10.1038/s42255-019-0076-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6837876PMC
June 2019

Glycogen Dynamics Drives Lipid Droplet Biogenesis during Brown Adipocyte Differentiation.

Authors:
Alicia Mayeuf-Louchart Steve Lancel Yasmine Sebti Benoit Pourcet Anne Loyens Stéphane Delhaye Christian Duhem Justine Beauchamp Lise Ferri Quentin Thorel Alexis Boulinguiez Mathilde Zecchin Julie Dubois-Chevalier Jérôme Eeckhoute Logan T Vaughn Peter J Roach Christian Dani Bartholomew A Pederson Stéphane D Vincent Bart Staels Hélène Duez

Cell Rep 2019 11;29(6):1410-1418.e6

Univ. Lille, INSERM, CHU Lille, Institut Pasteur de Lille, U1011-EGID, 59000 Lille, France.

View Article

Download full-text PDF

 Source
http://dx.doi.org/10.1016/j.celrep.2019.09.073DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7057258PMC
November 2019

Transcription profiling in the liver of undernourished male rat offspring reveals altered lipid metabolism pathways and predisposition to hepatic steatosis.

Authors:
Simon Lecoutre Valérie Montel Emmanuelle Vallez Charlène Pourpe Anne Delmont Elodie Eury Marie Verbanck Anne Dickes-Coopman Pierre Daubersies Jean Lesage Christine Laborie Anne Tailleux Bart Staels Philippe Froguel Christophe Breton Didier Vieau

Am J Physiol Endocrinol Metab 2019 12 22;317(6):E1094-E1107. Epub 2019 Oct 22.

Université Lille, EA4489, Equipe Malnutrition Maternelle et Programmation des Maladies Métaboliques, Lille, France.

View Article

Download full-text PDF

 Source
http://dx.doi.org/10.1152/ajpendo.00291.2019DOI Listing
December 2019

Mechanisms Underlying the Functional Cooperation Between PPARα and GRα to Attenuate Inflammatory Responses.

Authors:
Nadia Bougarne Viacheslav Mylka Dariusz Ratman Ilse M Beck Jonathan Thommis Lode De Cauwer Jan Tavernier Bart Staels Claude Libert Karolien De Bosscher

Front Immunol 2019 9;10:1769. Epub 2019 Aug 9.

Translational Nuclear Receptor Research Lab, Ghent, Belgium.

View Article

Download full-text PDF

 Source
http://dx.doi.org/10.3389/fimmu.2019.01769DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6695567PMC
August 2019

The GLP1R Agonist Liraglutide Reduces Hyperglucagonemia Induced by the SGLT2 Inhibitor Dapagliflozin via Somatostatin Release.

Authors:
Chiara Saponaro Valéry Gmyr Julien Thévenet Ericka Moerman Nathalie Delalleau Gianni Pasquetti Anais Coddeville Audrey Quenon Mehdi Daoudi Thomas Hubert Marie-Christine Vantyghem Corinne Bousquet Yvan Martineau Julie Kerr-Conte Bart Staels François Pattou Caroline Bonner

Cell Rep 2019 08;28(6):1447-1454.e4

University of Lille, U1190-EGID, 59000 Lille, France; INSERM, U1190, 59000 Lille, France; Institut Pasteur de Lille, 59000 Lille, France. Electronic address:

View Article

Download full-text PDF

 Source
http://dx.doi.org/10.1016/j.celrep.2019.07.009DOI Listing
August 2019

Near-infrared light activatable hydrogels for metformin delivery.

Authors:
Li Chengnan Quentin Pagneux Anna Voronova Alexandre Barras Amar Abderrahmani Valérie Plaisance Valerie Pawlowski Nathalie Hennuyer Bart Staels Lea Rosselle Nadia Skandrani Musen Li Rabah Boukherroub Sabine Szunerits

Nanoscale 2019 Aug;11(34):15810-15820

Univ. Lille, CNRS, Centrale Lille, ISEN, Univ. Valenciennes, UMR 8520 - IEMN, F-59000 Lille, France.

View Article

Download full-text PDF

 Source
http://dx.doi.org/10.1039/c9nr02707fDOI Listing
August 2019

FXR overexpression alters adipose tissue architecture in mice and limits its storage capacity leading to metabolic derangements.

Authors:
Tim van Zutphen Johanna H M Stroeve Jiufang Yang Vincent W Bloks Angelika Jurdzinski Han Roelofsen Nicolette C A Huijkman Theo H van Dijk Roel J Vonk Jan van Deursen Bart Staels Albert K Groen Folkert Kuipers

J Lipid Res 2019 09 28;60(9):1547-1561. Epub 2019 Jun 28.

Departments of PediatricsUniversity of Groningen, Groningen 9700 RB, The Netherlands

View Article

Download full-text PDF

 Source
http://dx.doi.org/10.1194/jlr.M094508DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6718433PMC
September 2019

Metabolic and Innate Immune Cues Merge into a Specific Inflammatory Response via the UPR.

Authors:
Denis A Mogilenko Joel T Haas Laurent L'homme Sébastien Fleury Sandrine Quemener Matthieu Levavasseur Coralie Becquart Julien Wartelle Alexandra Bogomolova Laurent Pineau Olivier Molendi-Coste Steve Lancel Hélène Dehondt Celine Gheeraert Aurelie Melchior Cédric Dewas Artemii Nikitin Samuel Pic Nabil Rabhi Jean-Sébastien Annicotte Seiichi Oyadomari Talia Velasco-Hernandez Jörg Cammenga Marc Foretz Benoit Viollet Milica Vukovic Arnaud Villacreces Kamil Kranc Peter Carmeliet Guillemette Marot Alexis Boulter Simon Tavernier Luciana Berod Maria P Longhi Christophe Paget Sophie Janssens Delphine Staumont-Sallé Ezra Aksoy Bart Staels David Dombrowicz

Cell 2019 Jun;178(1):263

View Article

Download full-text PDF

 Source
https://linkinghub.elsevier.com/retrieve/pii/S00928674193068
Publisher Site
http://dx.doi.org/10.1016/j.cell.2019.06.017DOI Listing
June 2019

Mathematical models converge on PGC1α as the key metabolic integrator of SIRT1 and AMPK regulation of the circadian clock.

Authors:
Alessandro Furlan Marine Jacquier Aurore Woller Laurent Héliot Hélène Duez Bart Staels Marc Lefranc

Proc Natl Acad Sci U S A 2019 07 25;116(27):13171-13172. Epub 2019 Jun 25.

University of Lille, CNRS, UMR 8523, PhLAM-Physique des Lasers Atomes et Molécules, F-59000 Lille, France;

View Article

Download full-text PDF

 Source
http://dx.doi.org/10.1073/pnas.1907751116DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6613102PMC
July 2019

Hepatic transcriptomic signatures of statin treatment are associated with impaired glucose homeostasis in severely obese patients.

Authors:
Daniel Margerie Philippe Lefebvre Violeta Raverdy Uwe Schwahn Hartmut Ruetten Philip Larsen Alain Duhamel Julien Labreuche Dorothée Thuillier Bruno Derudas Céline Gheeraert Hélène Dehondt Quentin Dhalluin Jérémy Alexandre Robert Caiazzo Pamela Nesslany Helene Verkindt François Pattou Bart Staels

BMC Med Genomics 2019 06 3;12(1):80. Epub 2019 Jun 3.

Univ. Lille, INSERM, CHU Lille, Institut Pasteur de Lille, U1011 - EGID, F-59000, Lille, France.

View Article

Download full-text PDF

 Source
http://dx.doi.org/10.1186/s12920-019-0536-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6545676PMC
June 2019

Metabolic and Innate Immune Cues Merge into a Specific Inflammatory Response via the UPR.

Authors:
Denis A Mogilenko Joel T Haas Laurent L'homme Sébastien Fleury Sandrine Quemener Matthieu Levavasseur Coralie Becquart Julien Wartelle Alexandra Bogomolova Laurent Pineau Olivier Molendi-Coste Steve Lancel Hélène Dehondt Celine Gheeraert Aurelie Melchior Cédric Dewas Artemii Nikitin Samuel Pic Nabil Rabhi Jean-Sébastien Annicotte Seiichi Oyadomari Talia Velasco-Hernandez Jörg Cammenga Marc Foretz Benoit Viollet Milica Vukovic Arnaud Villacreces Kamil Kranc Peter Carmeliet Guillemette Marot Alexis Boulter Simon Tavernier Luciana Berod Maria P Longhi Christophe Paget Sophie Janssens Delphine Staumont-Sallé Ezra Aksoy Bart Staels David Dombrowicz

Cell 2019 05 25;177(5):1201-1216.e19. Epub 2019 Apr 25.

University of Lille, EGID, INSERM, CHU Lille, Institut Pasteur de Lille, U1011, 59019 Lille, France. Electronic address:

View Article

Download full-text PDF

 Source
http://dx.doi.org/10.1016/j.cell.2019.03.018DOI Listing
May 2019

Understanding lipid metabolism through hepatic steat-omics.

Authors:
Joel T Haas Bart Staels

Nat Rev Endocrinol 2019 06;15(6):321-322

INSERM UMR1011, European Genomic Institute for Diabetes, University of Lille, CHU Lille, Institut Pasteur de Lille, Lille, France.

View Article

Download full-text PDF

 Source
http://dx.doi.org/10.1038/s41574-019-0203-9DOI Listing
June 2019

Hepatocyte-specific loss of GPS2 in mice reduces non-alcoholic steatohepatitis via activation of PPARα.

Authors:
Ning Liang Anastasius Damdimopoulos Saioa Goñi Zhiqiang Huang Lise-Lotte Vedin Tomas Jakobsson Marco Giudici Osman Ahmed Matteo Pedrelli Serena Barilla Fawaz Alzaid Arturo Mendoza Tarja Schröder Raoul Kuiper Paolo Parini Anthony Hollenberg Philippe Lefebvre Sven Francque Luc Van Gaal Bart Staels Nicolas Venteclef Eckardt Treuter Rongrong Fan

Nat Commun 2019 04 11;10(1):1684. Epub 2019 Apr 11.

Department of Biosciences and Nutrition, Karolinska Institutet, Huddinge, 14157, Sweden.

View Article

Download full-text PDF

 Source
http://dx.doi.org/10.1038/s41467-019-09524-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6459876PMC
April 2019

The circadian clock and liver function in health and disease.

Authors:
Atish Mukherji Shannon M Bailey Bart Staels Thomas F Baumert

J Hepatol 2019 07 28;71(1):200-211. Epub 2019 Mar 28.

Institut de Recherche sur les Maladies Virales et Hépatiques INSERM, UMR 1110, Université de Strasbourg, Strasbourg, France; Pôle Hépato-Digestif, Institut Hospitalo-Universitaire, Hôpitaux Universitaires de Strasbourg, Strasbourg, France. Electronic address:

View Article

Download full-text PDF

 Source
https://linkinghub.elsevier.com/retrieve/pii/S01688278193019
Publisher Site
http://dx.doi.org/10.1016/j.jhep.2019.03.020DOI Listing
July 2019

Liver-specific RORα deletion does not affect the metabolic susceptibility to western style diet feeding.

Authors:
Antonio Molinaro Robert Caesar Laurent L'homme Ara Koh Marcus Ståhlman Bart Staels Fredrik Bäckhed

Mol Metab 2019 05 9;23:82-87. Epub 2019 Mar 9.

Wallenberg Laboratory, Department of Molecular and Clinical Medicine, Sahlgrenska Academy, University of Gothenburg, 413 45, Gothenburg, Sweden; Novo Nordisk Foundation Center for Basic Metabolic Research and Section for Metabolic Receptology and Enteroendocrinology, Faculty of Health Sciences, University of Copenhagen, Copenhagen, 2200, Denmark. Electronic address:

View Article

Download full-text PDF

 Source
http://dx.doi.org/10.1016/j.molmet.2019.02.010DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6479759PMC
May 2019

Dietary Sargassum fusiforme improves memory and reduces amyloid plaque load in an Alzheimer's disease mouse model.

Authors:
Jeroen Bogie Cindy Hoeks Melissa Schepers Assia Tiane Ann Cuypers Frank Leijten Yupyn Chintapakorn Thiti Suttiyut Surachai Pornpakakul Dicky Struik Anja Kerksiek Hong-Bing Liu Niels Hellings Pilar Martinez-Martinez Johan W Jonker Ilse Dewachter Eric Sijbrands Jochen Walter Jerome Hendriks Albert Groen Bart Staels Dieter Lütjohann Tim Vanmierlo Monique Mulder

Sci Rep 2019 03 20;9(1):4908. Epub 2019 Mar 20.

Department of Internal Medicine, Laboratory of Vascular Medicine, Erasmus University Medical Center, Wytemaweg 80, 3015 CN, Rotterdam, The Netherlands.

View Article

Download full-text PDF

 Source
http://dx.doi.org/10.1038/s41598-019-41399-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6426980PMC
March 2019

Sex-regulated gene dosage effect of PPARα on synaptic plasticity.

Authors:
Nathalie Pierrot Laurence Ris Ilie-Cosmin Stancu Anna Doshina Floriane Ribeiro Donatienne Tyteca Eric Baugé Fanny Lalloyer Liza Malong Olivier Schakman Karelle Leroy Pascal Kienlen-Campard Philippe Gailly Jean-Pierre Brion Ilse Dewachter Bart Staels Jean-Noël Octave

Life Sci Alliance 2019 04 20;2(2). Epub 2019 Mar 20.

Université Catholique de Louvain, Brussels, Belgium.

View Article

Download full-text PDF

 Source
http://dx.doi.org/10.26508/lsa.201800262DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6427998PMC
April 2019

Bile acid alterations in nonalcoholic fatty liver disease, obesity, insulin resistance and type 2 diabetes: what do the human studies tell?

Authors:
Oscar Chávez-Talavera Joel Haas Guillaume Grzych Anne Tailleux Bart Staels

Curr Opin Lipidol 2019 06;30(3):244-254

View Article

Download full-text PDF

 Source
http://dx.doi.org/10.1097/MOL.0000000000000597DOI Listing
June 2019

The LPS/D-Galactosamine-Induced Fulminant Hepatitis Model to Assess the Role of Ligand-Activated Nuclear Receptors on the NLRP3 Inflammasome Pathway In Vivo.

Authors:
Yasmine Sebti Lise Ferri Mathilde Zecchin Justine Beauchamp Denis Mogilenko Bart Staels Hélène Duez Benoit Pourcet

Methods Mol Biol 2019 ;1951:189-207

European Genomic Institute for Diabetes (E.G.I.D.), Lille, France.

View Article

Download full-text PDF

 Source
http://dx.doi.org/10.1007/978-1-4939-9130-3_15DOI Listing
July 2019

Hepatic PPARα is critical in the metabolic adaptation to sepsis.

Authors:
Réjane Paumelle Joel T Haas Nathalie Hennuyer Eric Baugé Yann Deleye Dieter Mesotten Lies Langouche Jonathan Vanhoutte Céline Cudejko Kristiaan Wouters Sarah Anissa Hannou Vanessa Legry Steve Lancel Fanny Lalloyer Arnaud Polizzi Sarra Smati Pierre Gourdy Emmanuelle Vallez Emmanuel Bouchaert Bruno Derudas Hélène Dehondt Céline Gheeraert Sébastien Fleury Anne Tailleux Alexandra Montagner Walter Wahli Greet Van Den Berghe Hervé Guillou David Dombrowicz Bart Staels

J Hepatol 2019 05 21;70(5):963-973. Epub 2019 Jan 21.

Univ. Lille, Inserm, CHU Lille, Institut Pasteur de Lille, U1011 - EGID, F-59000 Lille, France. Electronic address:

View Article

Download full-text PDF

 Source
http://dx.doi.org/10.1016/j.jhep.2018.12.037DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6774768PMC
May 2019

Brain insulin response and peripheral metabolic changes in a Tau transgenic mouse model.

Authors:
Antoine Leboucher Tariq Ahmed Emilie Caron Anne Tailleux Sylvie Raison Aurélie Joly-Amado Elodie Marciniak Kevin Carvalho Malika Hamdane Kadiombo Bantubungi Steve Lancel Sabiha Eddarkaoui Raphaelle Caillierez Emmanuelle Vallez Bart Staels Didier Vieau Detlef Balschun Luc Buee David Blum

Neurobiol Dis 2019 05 19;125:14-22. Epub 2019 Jan 19.

Univ. Lille, Inserm, CHU Lille, UMR-S 1172 - JPArc, F-59000 Lille, France; LabEx DISTALZ, F-59000 Lille, France. Electronic address:

View Article

Download full-text PDF

 Source
http://dx.doi.org/10.1016/j.nbd.2019.01.008DOI Listing
May 2019

ATF6α downregulation of PPARα promotes lipotoxicity-induced tubulointerstitial fibrosis.

Authors:
Tzu-Ming Jao Masaomi Nangaku Chia-Hsien Wu Mai Sugahara Hisako Saito Hiroshi Maekawa Yu Ishimoto Mari Aoe Tsuyoshi Inoue Tetsuhiro Tanaka Bart Staels Kazutoshi Mori Reiko Inagi

Kidney Int 2019 03 11;95(3):577-589. Epub 2019 Jan 11.

Division of Chronic Kidney Disease Pathophysiology, The University of Tokyo Graduate School of Medicine, Tokyo, Japan. Electronic address:

View Article

Download full-text PDF

 Source
http://dx.doi.org/10.1016/j.kint.2018.09.023DOI Listing
March 2019

Combinatorial regulation of hepatic cytoplasmic signaling and nuclear transcriptional events by the OGT/REV-ERBα complex.

Authors:
Alexandre Berthier Manjula Vinod Geoffrey Porez Agata Steenackers Jérémy Alexandre Nao Yamakawa Céline Gheeraert Maheul Ploton Xavier Maréchal Julie Dubois-Chevalier Agnès Hovasse Christine Schaeffer-Reiss Sarah Cianférani Christian Rolando Fabrice Bray Hélène Duez Jérôme Eeckhoute Tony Lefebvre Bart Staels Philippe Lefebvre

Proc Natl Acad Sci U S A 2018 11 5;115(47):E11033-E11042. Epub 2018 Nov 5.

University of Lille, Inserm, Centre Hospitalier Universitaire de Lille, Institut Pasteur de Lille, European Genomic Institute for Diabetes, U1011, Lille F-59045, France;

View Article

Download full-text PDF

 Source
http://dx.doi.org/10.1073/pnas.1805397115DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6255172PMC
November 2018

Time to Check the Clock in Cardiovascular Research and Medicine.

Authors:
David Montaigne Bart Staels

Circ Res 2018 08;123(6):648-650

From the European Genomic Institute for Diabetes, University of Lille, France (D.M., B.S.).

View Article

Download full-text PDF

 Source
http://dx.doi.org/10.1161/CIRCRESAHA.118.313543DOI Listing
August 2018

Epicardial fat amount is associated with the magnitude of left ventricular remodeling in aortic stenosis.

Authors:
Augustin Coisne Sandro Ninni Staniel Ortmans Laurent Davin Kevin Kasprzak Benjamin Longère Claire Seunes Amandine Coppin Stéphanie Mouton Hélène Ridon Cedric Klein Brieuc Noirot-Cosson Bart Staels Patrizio Lancellotti David Montaigne François Pontana

Int J Cardiovasc Imaging 2019 Feb 17;35(2):267-273. Epub 2018 Oct 17.

European Genomic Institute for Diabetes (E.G.I.D), FR 3508, 59000, Lille, France.

View Article

Download full-text PDF

 Source
http://link.springer.com/10.1007/s10554-018-1477-z
Publisher Site
http://dx.doi.org/10.1007/s10554-018-1477-zDOI Listing
February 2019

Heart failure and diabetes: metabolic alterations and therapeutic interventions: a state-of-the-art review from the Translational Research Committee of the Heart Failure Association-European Society of Cardiology.

Authors:
Christoph Maack Michael Lehrke Johannes Backs Frank R Heinzel Jean-Sebastien Hulot Nikolaus Marx Walter J Paulus Patrick Rossignol Heinrich Taegtmeyer Johann Bauersachs Antoni Bayes-Genis Dirk Brutsaert Heiko Bugger Kieran Clarke Francesco Cosentino Gilles De Keulenaer Alessandra Dei Cas Arantxa González Martin Huelsmann Guido Iaccarino Ida Gjervold Lunde Alexander R Lyon Piero Pollesello Graham Rena Niels P Riksen Giuseppe Rosano Bart Staels Linda W van Laake Christoph Wanner Dimitrios Farmakis Gerasimos Filippatos Frank Ruschitzka Petar Seferovic Rudolf A de Boer Stephane Heymans

Eur Heart J 2018 12;39(48):4243-4254

Department of Cardiology, Cardiovascular Research Institute Maastricht, Maastricht University Medical Centre, Maastricht, The Netherlands.

View Article

Download full-text PDF

 Source
https://academic.oup.com/eurheartj/advance-article/doi/10.10
Publisher Site
http://dx.doi.org/10.1093/eurheartj/ehy596DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6302261PMC
December 2018

Circulating PCSK9 levels are not associated with the severity of hepatic steatosis and NASH in a high-risk population.

Authors:
Matthieu Wargny Pierre-Henri Ducluzeau Jean-Michel Petit Cédric Le May Sarra Smati Lucie Arnaud Matthieu Pichelin Benjamin Bouillet Adrien Lannes Odile Blanchet Philippe Lefebvre Sven Francque Luc Van Gaal Bart Staels Bruno Vergès Jérôme Boursier Bertrand Cariou

Atherosclerosis 2018 11 13;278:82-90. Epub 2018 Sep 13.

L'institut du thorax, Department of Endocrinology, CIC 1413 INSERM, CHU Nantes, Nantes, France; L'institut du thorax, INSERM, CNRS, CHU Nantes, Nantes, France. Electronic address:

View Article

Download full-text PDF

 Source
http://dx.doi.org/10.1016/j.atherosclerosis.2018.09.008DOI Listing
November 2018

Retinoids Issued from Hepatic Stellate Cell Lipid Droplet Loss as Potential Signaling Molecules Orchestrating a Multicellular Liver Injury Response.

Authors:
Marie Bobowski-Gerard Francesco Paolo Zummo Bart Staels Philippe Lefebvre Jérôme Eeckhoute

Cells 2018 Sep 13;7(9). Epub 2018 Sep 13.

Institut Pasteur de Lille, The University of Lille, Inserm, CHU Lille, U1011-EGID, F-59000 Lille, France.

View Article

Download full-text PDF

 Source
http://dx.doi.org/10.3390/cells7090137DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6162435PMC
September 2018

Keratinocyte Expression of A20/TNFAIP3 Controls Skin Inflammation Associated with Atopic Dermatitis and Psoriasis.

Authors:
Michael Devos Denis A Mogilenko Sébastien Fleury Barbara Gilbert Coralie Becquart Sandrine Quemener Hélène Dehondt Peter Tougaard Bart Staels Claus Bachert Peter Vandenabeele Geert Van Loo Delphine Staumont-Salle Wim Declercq David Dombrowicz

J Invest Dermatol 2019 01 14;139(1):135-145. Epub 2018 Aug 14.

Université de Lille, INSERM, Centre Hospitalier Universitaire de Lille, Institut Pasteur de Lille, U1011-EGID, Lille, France. Electronic address:

View Article

Download full-text PDF

 Source
http://dx.doi.org/10.1016/j.jid.2018.06.191DOI Listing
January 2019

MuscleJ: a high-content analysis method to study skeletal muscle with a new Fiji tool.

Authors:
Alicia Mayeuf-Louchart David Hardy Quentin Thorel Pascal Roux Lorna Gueniot David Briand Aurélien Mazeraud Adrien Bouglé Spencer L Shorte Bart Staels Fabrice Chrétien Hélène Duez Anne Danckaert

Skelet Muscle 2018 08 6;8(1):25. Epub 2018 Aug 6.

Experimental Neuropathology Unit, Infection and Epidemiology Department, Institut Pasteur, 25, rue du Docteur Roux, 75015, Paris, France.

View Article

Download full-text PDF

 Source
http://dx.doi.org/10.1186/s13395-018-0171-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6091189PMC
August 2018

Peri-operative acute kidney injury upon cardiac surgery time-of-day.

Authors:
Sandro Ninni Claire Seunes Staniel Ortmans Stéphanie Mouton Thomas Modine Mohamed Koussa Bruno Jegou Jean-Louis Edme Bart Staels David Montaigne Augustin Coisne

Int J Cardiol 2018 Dec 19;272:54-59. Epub 2018 Jul 19.

CHU Lille, Department of Clinical Physiology and Echocardiography, Heart Valve Clinic, F-59000 Lille, France; European Genomic Institute for Diabetes (E.G.I.D), Univ Lille, F-59000 Lille, France; Inserm, U1011, F-59000 Lille, France; Institut Pasteur de Lille, F-59019 Lille, France. Electronic address:

View Article

Download full-text PDF

 Source
http://dx.doi.org/10.1016/j.ijcard.2018.07.081DOI Listing
December 2018

Molecular Actions of PPARα in Lipid Metabolism and Inflammation.

Authors:
Nadia Bougarne Basiel Weyers Sofie J Desmet Julie Deckers David W Ray Bart Staels Karolien De Bosscher

Endocr Rev 2018 10;39(5):760-802

Department of Biomolecular Medicine, Ghent University, Ghent, Belgium.

View Article

Download full-text PDF

 Source
https://academic.oup.com/edrv/article/39/5/760/5055100
Publisher Site
http://dx.doi.org/10.1210/er.2018-00064DOI Listing
October 2018

Circadian misalignment induces fatty acid metabolism gene profiles and compromises insulin sensitivity in human skeletal muscle.

Authors:
Jakob Wefers Dirk van Moorsel Jan Hansen Niels J Connell Bas Havekes Joris Hoeks Wouter D van Marken Lichtenbelt Hélène Duez Esther Phielix Andries Kalsbeek Mark V Boekschoten Guido J Hooiveld Matthijs K C Hesselink Sander Kersten Bart Staels Frank A J L Scheer Patrick Schrauwen

Proc Natl Acad Sci U S A 2018 07 9;115(30):7789-7794. Epub 2018 Jul 9.

Department of Nutrition and Movement Sciences, School for Nutrition and Translational Research in Metabolism, Maastricht University Medical Center, 6200 MD Maastricht, The Netherlands;

View Article

Download full-text PDF

 Source
http://dx.doi.org/10.1073/pnas.1722295115DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6065021PMC
July 2018

The nuclear bile acid receptor FXR is a PKA- and FOXA2-sensitive activator of fasting hepatic gluconeogenesis.

Authors:
Maheul Ploton Claire Mazuy Céline Gheeraert Vanessa Dubois Alexandre Berthier Julie Dubois-Chevalier Xavier Maréchal Kadiombo Bantubungi Hélène Diemer Sarah Cianférani Jean-Marc Strub Audrey Helleboid-Chapman Jérôme Eeckhoute Bart Staels Philippe Lefebvre

J Hepatol 2018 Nov 5;69(5):1099-1109. Epub 2018 Jul 5.

Univ. Lille, Inserm, CHU Lille, Institut Pasteur de Lille, U1011 - EGID, F-59000 Lille, France. Electronic address:

View Article

Download full-text PDF

 Source
https://linkinghub.elsevier.com/retrieve/pii/S01688278183217
Publisher Site
http://dx.doi.org/10.1016/j.jhep.2018.06.022DOI Listing
November 2018

Development and implementation of a cell-based assay to discover agonists of the nuclear receptor REV-ERBα.

Authors:
Yuliya Hering Alexandre Berthier Helene Duez Philippe Lefebvre Benoit Deprez Philip Gribbon Markus Wolf Jeanette Reinshagen Francoise Halley Juliane Hannemann Rainer Böger Bart Staels Sheraz Gul

J Biol Methods 2018 25;5(3):e94. Epub 2018 Jun 25.

Fraunhofer Institute for Molecular Biology and Applied Ecology, ScreeningPort, Schnackenburgallee 114, D-22525 Hamburg, Germany.

View Article

Download full-text PDF

 Source
http://dx.doi.org/10.14440/jbm.2018.244DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6706147PMC
June 2018

Obesity Paradox in the Clinical Significance of Effective Prosthetic Orifice Area After Aortic Valve Replacement.

Authors:
Augustin Coisne Sandro Ninni Jean-Louis Edmé Thomas Modine Stéphanie Mouton Rosario Pilato Hélène Ridon Marjorie Richardson Cedric Klein Staniel Ortmans Claire Seunes Anne-Laure Madika Guillaume Ledieu Mathilde Jacquelinet Bertrand Boutie Alexandre Altes Flavien Vincent Mohamad Koussa Bruno Jegou André Vincentelli Francis Juthier Emmanuel Robin Bart Staels Patrizio Lancellotti David Montaigne

JACC Cardiovasc Imaging 2019 01 13;12(1):208-210. Epub 2018 Jun 13.

View Article

Download full-text PDF

 Source
https://linkinghub.elsevier.com/retrieve/pii/S1936878X183037
Publisher Site
http://dx.doi.org/10.1016/j.jcmg.2018.04.018DOI Listing
January 2019

Daytime variations in perioperative myocardial injury - Authors' reply.

Authors:
David Montaigne Augustin Coisne Xavier Marechal Philippe Lefebvre Bart Staels

Lancet 2018 05 24;391(10135):2106. Epub 2018 May 24.

University of Lille, EGID, F-59000 Lille, France; Inserm, U1011, F-Lille, France; University Hospital CHU Lille, Lille, France; Institut Pasteur de Lille, Lille, France.

View Article

Download full-text PDF

 Source
http://dx.doi.org/10.1016/S0140-6736(18)30758-XDOI Listing
May 2018

Arterial Pulsatility and Circulating von Willebrand Factor in Patients on Mechanical Circulatory Support.

Authors:
Flavien Vincent Antoine Rauch Valentin Loobuyck Emmanuel Robin Christoph Nix André Vincentelli David M Smadja Pascal Leprince Julien Amour Gilles Lemesle Hugues Spillemaeker Nicolas Debry Christian Latremouille Piet Jansen Antoine Capel Mouhamed Moussa Natacha Rousse Guillaume Schurtz Cédric Delhaye Camille Paris Emmanuelle Jeanpierre Annabelle Dupont Delphine Corseaux Mickaël Rosa Yoann Sottejeau Svenja Barth Claudia Mourran Valérie Gomane Augustin Coisne Marjorie Richardson Claudine Caron Cristian Preda Alexandre Ung Alain Carpentier Thomas Hubert Cécile Denis Bart Staels Peter J Lenting Eric Van Belle Sophie Susen

J Am Coll Cardiol 2018 05;71(19):2106-2118

University of Lille, INSERM U1011-EGID, Lille, France; Institut Pasteur de Lille, Lille, France; CHU Lille, Hematology Transfusion, Lille, France. Electronic address:

View Article

Download full-text PDF

 Source
http://dx.doi.org/10.1016/j.jacc.2018.02.075DOI Listing
May 2018

Increased Hepatic PDGF-AA Signaling Mediates Liver Insulin Resistance in Obesity-Associated Type 2 Diabetes.

Authors:
Amar Abderrahmani Loïc Yengo Robert Caiazzo Mickaël Canouil Stéphane Cauchi Violeta Raverdy Valérie Plaisance Valérie Pawlowski Stéphane Lobbens Julie Maillet Laure Rolland Raphael Boutry Gurvan Queniat Maxime Kwapich Mathie Tenenbaum Julien Bricambert Sophie Saussenthaler Elodie Anthony Pooja Jha Julien Derop Olivier Sand Iandry Rabearivelo Audrey Leloire Marie Pigeyre Martine Daujat-Chavanieu Sabine Gerbal-Chaloin Tasnim Dayeh Guillaume Lassailly Philippe Mathurin Bart Staels Johan Auwerx Annette Schürmann Catherine Postic Clemens Schafmayer Jochen Hampe Amélie Bonnefond François Pattou Philippe Froguel

Diabetes 2018 07 4;67(7):1310-1321. Epub 2018 May 4.

University Lille, Centre National de la Recherche Scientifique, Institut Pasteur de Lille, UMR 8199 - European Genomic Institute for Diabetes, Lille, France

View Article

Download full-text PDF

 Source
http://dx.doi.org/10.2337/db17-1539DOI Listing
July 2018

Endospanin-2 enhances skeletal muscle energy metabolism and running endurance capacity.

Authors:
Steve Lancel Matthijs Kc Hesselink Estelle Woldt Yves Rouillé Emilie Dorchies Stephane Delhaye Christian Duhem Quentin Thorel Alicia Mayeuf-Louchart Benoit Pourcet Valérie Montel Gert Schaart Nicolas Beton Florence Picquet Olivier Briand Jean Pierre Salles Hélène Duez Patrick Schrauwen Bruno Bastide Bernard Bailleul Bart Staels Yasmine Sebti

JCI Insight 2018 05 3;3(9). Epub 2018 May 3.

Université de Lille, U1011 - EGID, F-59000 Lille, France.

View Article

Download full-text PDF

 Source
http://dx.doi.org/10.1172/jci.insight.98081DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6012521PMC
May 2018

Alternative macrophages in atherosclerosis: not always protective!

Authors:
Benoit Pourcet Bart Staels

J Clin Invest 2018 03 19;128(3):910-912. Epub 2018 Feb 19.

View Article

Download full-text PDF

 Source
http://dx.doi.org/10.1172/JCI120123DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5824921PMC
March 2018

Nuclear Receptor Subfamily 1 Group D Member 1 Regulates Circadian Activity of NLRP3 Inflammasome to Reduce the Severity of Fulminant Hepatitis in Mice.

Authors:
Benoit Pourcet Mathilde Zecchin Lise Ferri Justine Beauchamp Sadicha Sitaula Cyrielle Billon Stéphane Delhaye Jonathan Vanhoutte Alicia Mayeuf-Louchart Quentin Thorel Joel T Haas Jérome Eeckhoute David Dombrowicz Christian Duhem Alexis Boulinguiez Steve Lancel Yasmine Sebti Thomas P Burris Bart Staels Hélène M Duez

Gastroenterology 2018 04 24;154(5):1449-1464.e20. Epub 2017 Dec 24.

Univ. Lille, Inserm, CHU Lille, Institut Pasteur de Lille, U1011 - EGID, F-59000, Lille, France. Electronic address:

View Article

Download full-text PDF

 Source
http://dx.doi.org/10.1053/j.gastro.2017.12.019DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5892845PMC
April 2018

Daytime variation of perioperative myocardial injury in cardiac surgery and its prevention by Rev-Erbα antagonism: a single-centre propensity-matched cohort study and a randomised study.

Authors:
David Montaigne Xavier Marechal Thomas Modine Augustin Coisne Stéphanie Mouton Georges Fayad Sandro Ninni Cédric Klein Staniel Ortmans Claire Seunes Charlotte Potelle Alexandre Berthier Celine Gheeraert Catherine Piveteau Rebecca Deprez Jérome Eeckhoute Hélène Duez Dominique Lacroix Benoit Deprez Bruno Jegou Mohamed Koussa Jean-Louis Edme Philippe Lefebvre Bart Staels

Lancet 2018 01 26;391(10115):59-69. Epub 2017 Oct 26.

University of Lille, EGID, Lille, France; Inserm, U1011, Lille, France; University Hospital CHU Lille, Lille, France; Institut Pasteur de Lille, Lille, France.

View Article

Download full-text PDF

 Source
http://dx.doi.org/10.1016/S0140-6736(17)32132-3DOI Listing
January 2018

Organizing combinatorial transcription factor recruitment at cis-regulatory modules.

Authors:
Julie Dubois-Chevalier Parisa Mazrooei Mathieu Lupien Bart Staels Philippe Lefebvre Jérôme Eeckhoute

Transcription 2018 28;9(4):233-239. Epub 2017 Nov 28.

a Université de Lille - Inserm - Chru de Lille, Institut Pasteur de Lille , U1011- EGID, F-59000 Lille , France.

View Article

Download full-text PDF

 Source
http://dx.doi.org/10.1080/21541264.2017.1394424DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6104691PMC
October 2018

Rev-erb-α regulates atrophy-related genes to control skeletal muscle mass.

Authors:
Alicia Mayeuf-Louchart Quentin Thorel Stéphane Delhaye Justine Beauchamp Christian Duhem Anne Danckaert Steve Lancel Benoit Pourcet Estelle Woldt Alexis Boulinguiez Lise Ferri Mathilde Zecchin Bart Staels Yasmine Sebti Hélène Duez

Sci Rep 2017 10 30;7(1):14383. Epub 2017 Oct 30.

Univ. Lille, Inserm, CHU Lille, Institut Pasteur de Lille, U1011 - EGID, F-59000, Lille, France.

View Article

Download full-text PDF

 Source
http://dx.doi.org/10.1038/s41598-017-14596-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5662766PMC
October 2017

The RBM14/CoAA-interacting, long intergenic non-coding RNA Paral1 regulates adipogenesis and coactivates the nuclear receptor PPARγ.

Authors:
François F Firmin Frederik Oger Céline Gheeraert Julie Dubois-Chevalier Anne-Sophie Vercoutter-Edouart Fawaz Alzaid Claire Mazuy Hélène Dehondt Jeremy Alexandre Bruno Derudas Quentin Dhalluin Maheul Ploton Alexandre Berthier Eloise Woitrain Tony Lefebvre Nicolas Venteclef François Pattou Bart Staels Jérôme Eeckhoute Philippe Lefebvre

Sci Rep 2017 10 26;7(1):14087. Epub 2017 Oct 26.

Univ. Lille, Inserm, CHU Lille, Institut Pasteur de Lille, U1011- EGID, F-59000, Lille, France.

View Article

Download full-text PDF

 Source
http://dx.doi.org/10.1038/s41598-017-14570-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5658386PMC
October 2017

Risperidone-induced metabolic dysfunction is attenuated by Curcuma longa extract administration in mice.

Authors:
Florent Auger Françoise Martin Olivier Pétrault Jennifer Samaillie Thierry Hennebelle Mohamed-Sami Trabelsi François Bailleul Bart Staels Régis Bordet Patrick Duriez

Metab Brain Dis 2018 02 16;33(1):63-77. Epub 2017 Oct 16.

Inserm, CHU Lille, U1171 - Degenerative & Vascular Cognitive Disorders, University of Lille, F-59000, Lille, France.

View Article

Download full-text PDF

 Source
http://link.springer.com/10.1007/s11011-017-0133-y
Publisher Site
http://dx.doi.org/10.1007/s11011-017-0133-yDOI Listing
February 2018

Fasting the Microbiota to Improve Metabolism?

Authors:
Joel T Haas Bart Staels

Cell Metab 2017 Oct;26(4):584-585

European Genomic Institute for Diabetes (E.G.I.D), University of Lille, EGID, 59000 Lille, France; INSERM UMR 1011, 59000 Lille, France; Institut Pasteur de Lille, 59000 Lille, France; University Hospital CHU Lille, 59000 Lille, France. Electronic address:

View Article

Download full-text PDF

 Source
http://dx.doi.org/10.1016/j.cmet.2017.09.013DOI Listing
October 2017

Bile Acid Alterations Are Associated With Insulin Resistance, but Not With NASH, in Obese Subjects.

Authors:
Vanessa Legry Sven Francque Joel T Haas An Verrijken Sandrine Caron Oscar Chávez-Talavera Emmanuelle Vallez Luisa Vonghia Eveline Dirinck Ann Verhaegen Mostafa Kouach Sophie Lestavel Philippe Lefebvre Luc Van Gaal Anne Tailleux Réjane Paumelle Bart Staels

J Clin Endocrinol Metab 2017 10;102(10):3783-3794

Université Lille, INSERM, Centre Hospitalier Universitaire de Lille, Institut Pasteur de Lille, U1011-European Genomic Institute for Diabetes, F-59000 Lille, France.

View Article

Download full-text PDF

 Source
http://dx.doi.org/10.1210/jc.2017-01397DOI Listing
October 2017

Ffar2 expression regulates leukaemic cell growth in vivo.

Authors:
Laure B Bindels Paolo E Porporato Sarah Ducastel Martina Sboarina Audrey M Neyrinck Evelyne M Dewulf Olivier Feron Sophie Lestavel Patrice D Cani Bart Staels Pierre Sonveaux Nathalie M Delzenne

Br J Cancer 2017 Oct 5;117(9):1336-1340. Epub 2017 Sep 5.

Metabolism and Nutrition Research Group, Louvain Drug Research Institute, Université Catholique de Louvain, Avenue Mounier 73, Box B1.73.11, Brussels 1200, Belgium.

View Article

Download full-text PDF

 Source
http://dx.doi.org/10.1038/bjc.2017.307DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5672929PMC
October 2017

The tumour suppressor CDKN2A/p16 regulates adipogenesis and bone marrow-dependent development of perivascular adipose tissue.

Authors:
Kristiaan Wouters Yann Deleye Sarah A Hannou Jonathan Vanhoutte Xavier Maréchal Augustin Coisne Madjid Tagzirt Bruno Derudas Emmanuel Bouchaert Christian Duhem Emmanuelle Vallez Casper G Schalkwijk François Pattou David Montaigne Bart Staels Réjane Paumelle

Diab Vasc Dis Res 2017 11 2;14(6):516-524. Epub 2017 Sep 2.

1 Université Lille 2, Inserm, CHU Lille, Institut Pasteur de Lille, U1011-EGID, Lille, France.

View Article

Download full-text PDF

 Source
http://dx.doi.org/10.1177/1479164117728012DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5652646PMC
November 2017

Circadian control of metabolism and pathological consequences of clock perturbations.

Authors:
Alicia Mayeuf-Louchart Mathilde Zecchin Bart Staels Hélène Duez

Biochimie 2017 Dec 2;143:42-50. Epub 2017 Aug 2.

Univ. Lille, Inserm, CHU Lille, Institut Pasteur de Lille, U1011 - EGID, F-59000, Lille, France. Electronic address:

View Article

Download full-text PDF

 Source
http://dx.doi.org/10.1016/j.biochi.2017.07.017DOI Listing
December 2017

Interspecies NASH disease activity whole-genome profiling identifies a fibrogenic role of PPARα-regulated dermatopontin.

Authors:
Philippe Lefebvre Fanny Lalloyer Eric Baugé Michal Pawlak Céline Gheeraert Hélène Dehondt Jonathan Vanhoutte Eloise Woitrain Nathalie Hennuyer Claire Mazuy Marie Bobowski-Gérard Francesco Paolo Zummo Bruno Derudas Ann Driessen Guy Hubens Luisa Vonghia Wilhelmus J Kwanten Peter Michielsen Thomas Vanwolleghem Jérôme Eeckhoute An Verrijken Luc Van Gaal Sven Francque Bart Staels

JCI Insight 2017 Jul 6;2(13). Epub 2017 Jul 6.

University Lille, Inserm, CHU-Lille, Institut Pasteur de Lille, U1011-EGID, Lille, France.

View Article

Download full-text PDF

 Source
http://dx.doi.org/10.1172/jci.insight.92264DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5499370PMC
July 2017

Tau deletion promotes brain insulin resistance.

Authors:
Elodie Marciniak Antoine Leboucher Emilie Caron Tariq Ahmed Anne Tailleux Julie Dumont Tarik Issad Ellen Gerhardt Patrick Pagesy Margaux Vileno Clément Bournonville Malika Hamdane Kadiombo Bantubungi Steve Lancel Dominique Demeyer Sabiha Eddarkaoui Emmanuelle Vallez Didier Vieau Sandrine Humez Emilie Faivre Benjamin Grenier-Boley Tiago F Outeiro Bart Staels Philippe Amouyel Detlef Balschun Luc Buee David Blum

J Exp Med 2017 Aug 26;214(8):2257-2269. Epub 2017 Jun 26.

Université de Lille, Institut National de la Santé et de la Recherche Medicale (INSERM), CHU Lille, UMR-S 1172 JPArc, Lille, France

View Article

Download full-text PDF

 Source
http://dx.doi.org/10.1084/jem.20161731DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5551570PMC
August 2017

Anti-diabetic activity of fused PPARγ-SIRT1 ligands with limited body-weight gain by mimicking calorie restriction and decreasing SGK1 expression.

Authors:
Celine Pirat Catherine Dacquet Veronique Leclerc Nathalie Hennuyer Monique Beucher-Gaudin Ghislaine Zanirato Anne Géant Bart Staels Alain Ktorza Amaury Farce Daniel-Henri Caignard Pascal Berthelot Nicolas Lebegue

Eur J Med Chem 2017 Sep 12;137:310-326. Epub 2017 Jun 12.

Univ. Lille, Inserm, CHU Lille, UMR-S 1172 - JPArc - Centre de Recherche Jean-Pierre AUBERT Neurosciences et Cancer, F-59000 Lille, France. Electronic address:

View Article

Download full-text PDF

 Source
http://dx.doi.org/10.1016/j.ejmech.2017.06.006DOI Listing
September 2017

Cardiovascular Protection by Sodium Glucose Cotransporter 2 Inhibitors: Potential Mechanisms.

Authors:
Bart Staels

Am J Cardiol 2017 07 30;120(1S):S28-S36. Epub 2017 May 30.

Université Lille, INSERM, CHU Lille, Institut Pasteur de Lille, U1011-EGID, Lille, France. Electronic address:

View Article

Download full-text PDF

 Source
http://dx.doi.org/10.1016/j.amjcard.2017.05.013DOI Listing
July 2017

Mitochondria and endoplasmic reticulum: Targets for a better insulin sensitivity in skeletal muscle?

Authors:
Alexis Boulinguiez Bart Staels Hélène Duez Steve Lancel

Biochim Biophys Acta Mol Cell Biol Lipids 2017 Sep 18;1862(9):901-916. Epub 2017 May 18.

Univ. Lille, Inserm, CHU Lille, Institut Pasteur de Lille, U1011 - EGID, F-59000, Lille, France. Electronic address:

View Article

Download full-text PDF

 Source
http://dx.doi.org/10.1016/j.bbalip.2017.05.011DOI Listing
September 2017

Cardiovascular Protection by Sodium Glucose Cotransporter 2 Inhibitors: Potential Mechanisms.

Authors:
Bart Staels

Am J Med 2017 Jun;130(6S):S30-S39

Université Lille, INSERM, CHU Lille, Institut Pasteur de Lille, U1011-EGID, Lille, France. Electronic address:

View Article

Download full-text PDF

 Source
http://dx.doi.org/10.1016/j.amjmed.2017.04.009DOI Listing
June 2017

Human Alternative Macrophages Populate Calcified Areas of Atherosclerotic Lesions and Display Impaired RANKL-Induced Osteoclastic Bone Resorption Activity.

Authors:
Giulia Chinetti-Gbaguidi Mehdi Daoudi Mickael Rosa Manjula Vinod Loïc Louvet Corinne Copin Mélanie Fanchon Jonathan Vanhoutte Bruno Derudas Loic Belloy Stephan Haulon Christophe Zawadzki Sophie Susen Ziad A Massy Jérôme Eeckhoute Bart Staels

Circ Res 2017 Jun 24;121(1):19-30. Epub 2017 Apr 24.

From the Université de Lille, Inserm, CHU Lille, Institut Pasteur de Lille, U1011, EGID, Lille, France (G.C.-G., M.D., M.R., M.V., C.C., M.F., J.V., B.D., L.B., C.Z., S.S., J.E., B.S.); University of Côte d'Azur, CHU, Inserm, CNRS, IRCAN, Nice, France (G.C.-G.); Inserm U1088, University of Picardie Jules Verne, and Amiens University Hospital, Amiens, France (L.L.); CHU Lille, Lille, France (S.H.); Division of Nephrology, Ambroise Paré University Hospital, AP-HP, Boulogne-Billancourt (Z.A.M.); and INSERM U1018, Team 5, CESP, UVSQ, Paris-Saclay University, Villejuif/Paris, France (Z.A.M.).

View Article

Download full-text PDF

 Source
http://dx.doi.org/10.1161/CIRCRESAHA.116.310262DOI Listing
June 2017

Topical Intestinal Aminoimidazole Agonists of G-Protein-Coupled Bile Acid Receptor 1 Promote Glucagon Like Peptide-1 Secretion and Improve Glucose Tolerance.

Authors:
Manuel Lasalle Vanessa Hoguet Nathalie Hennuyer Florence Leroux Catherine Piveteau Loïc Belloy Sophie Lestavel Emmanuelle Vallez Emilie Dorchies Isabelle Duplan Emmanuel Sevin Maxime Culot Fabien Gosselet Rajaa Boulahjar Adrien Herledan Bart Staels Benoit Deprez Anne Tailleux Julie Charton

J Med Chem 2017 05 5;60(10):4185-4211. Epub 2017 May 5.

Univ. Lille, Inserm, Institut Pasteur de Lille, U1177 - Drugs and Molecules for Living Systems, F-59000 Lille, France.

View Article

Download full-text PDF

 Source
http://dx.doi.org/10.1021/acs.jmedchem.6b01873DOI Listing
May 2017

The logic of transcriptional regulator recruitment architecture at -regulatory modules controlling liver functions.

Authors:
Julie Dubois-Chevalier Vanessa Dubois Hélène Dehondt Parisa Mazrooei Claire Mazuy Aurélien A Sérandour Céline Gheeraert Penderia Guillaume Eric Baugé Bruno Derudas Nathalie Hennuyer Réjane Paumelle Guillemette Marot Jason S Carroll Mathieu Lupien Bart Staels Philippe Lefebvre Jérôme Eeckhoute

Genome Res 2017 06 11;27(6):985-996. Epub 2017 Apr 11.

Université Lille, Inserm, CHU Lille, Institut Pasteur de Lille, U1011-EGID, F-59000 Lille, France.

View Article

Download full-text PDF

 Source
http://dx.doi.org/10.1101/gr.217075.116DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5453331PMC
June 2017

Targeting the gut microbiota with inulin-type fructans: preclinical demonstration of a novel approach in the management of endothelial dysfunction.

Authors:
Emilie Catry Laure B Bindels Anne Tailleux Sophie Lestavel Audrey M Neyrinck Jean-François Goossens Irina Lobysheva Hubert Plovier Ahmed Essaghir Jean-Baptiste Demoulin Caroline Bouzin Barbara D Pachikian Patrice D Cani Bart Staels Chantal Dessy Nathalie M Delzenne

Gut 2018 02 4;67(2):271-283. Epub 2017 Apr 4.

Metabolism and Nutrition Research Group, Louvain Drug Research Institute, Université catholique de Louvain, Brussels, Belgium.

View Article

Download full-text PDF

 Source
http://dx.doi.org/10.1136/gutjnl-2016-313316DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5868295PMC
February 2018

Distinct but complementary contributions of PPAR isotypes to energy homeostasis.

Authors:
Vanessa Dubois Jérôme Eeckhoute Philippe Lefebvre Bart Staels

J Clin Invest 2017 Apr 3;127(4):1202-1214. Epub 2017 Apr 3.

View Article

Download full-text PDF

 Source
http://dx.doi.org/10.1172/JCI88894DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5373878PMC
April 2017

Leptin induces osteoblast differentiation of human valvular interstitial cells via the Akt and ERK pathways.

Authors:
Mickael Rosa Camille Paris Yoann Sottejeau Delphine Corseaux Emmanuel Robin Madjid Tagzirt Francis Juthier Ramadan Jashari Antoine Rauch André Vincentelli Bart Staels Eric Van Belle Sophie Susen Annabelle Dupont

Acta Diabetol 2017 Jun 18;54(6):551-560. Epub 2017 Mar 18.

European Genomic Institute for Diabetes (E.G.I.D.), FR 3508, UNIV LILLE, Inserm UMR 1011, 59000, Lille, France.

View Article

Download full-text PDF

 Source
http://dx.doi.org/10.1007/s00592-017-0980-3DOI Listing
June 2017

Bile Acid Control of Metabolism and Inflammation in Obesity, Type 2 Diabetes, Dyslipidemia, and Nonalcoholic Fatty Liver Disease.

Authors:
Oscar Chávez-Talavera Anne Tailleux Philippe Lefebvre Bart Staels

Gastroenterology 2017 05 15;152(7):1679-1694.e3. Epub 2017 Feb 15.

Univ. Lille, Inserm, CHU Lille, Institut Pasteur de Lille, U1011 - EGID, F-59000 Lille, France. Electronic address:

View Article

Download full-text PDF

 Source
http://dx.doi.org/10.1053/j.gastro.2017.01.055DOI Listing
May 2017

Anacetrapib, but not evacetrapib, impairs endothelial function in CETP-transgenic mice in spite of marked HDL-C increase.

Authors:
Branko Simic Pavani Mocharla Margot Crucet Elena Osto Adelheid Kratzer Simona Stivala Susan Kühnast Thimoteus Speer Petia Doycheva Hans M Princen Jose W van der Hoorn J Wouter Jukema Hector Giral Anne Tailleux Ulf Landmesser Bart Staels Thomas F Lüscher

Atherosclerosis 2017 02 16;257:186-194. Epub 2017 Jan 16.

Center for Molecular Cardiology, Campus Schlieren, University of Zürich, Switzerland; University Heart Center, Cardiology, University Hospital Zürich, Switzerland. Electronic address:

View Article

Download full-text PDF

 Source
http://dx.doi.org/10.1016/j.atherosclerosis.2017.01.011DOI Listing
February 2017

Natalizumab Treatment Modulates Peroxisome Proliferator-Activated Receptors Expression in Women with Multiple Sclerosis.

Authors:
Véronique Ferret-Sena Alexandra Maia E Silva Armando Sena Inês Cavaleiro José Vale Bruno Derudas Giulia Chinetti-Gbaguidi Bart Staels

PPAR Res 2016 18;2016:5716415. Epub 2016 Dec 18.

University of Lille, Inserm, CHU Lille, Institut Pasteur de Lille, Lille, France.

View Article

Download full-text PDF

 Source
http://dx.doi.org/10.1155/2016/5716415DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5203914PMC
December 2016

Inactivation of the Nuclear Orphan Receptor COUP-TFII by Small Chemicals.

Authors:
Rémy Le Guével Frédérik Oger Celia P Martinez-Jimenez Maud Bizot Céline Gheeraert François Firmin Maheul Ploton Miroslava Kretova Gaëlle Palierne Bart Staels Peter Barath Iannis Talianidis Philippe Lefebvre Jérôme Eeckhoute Gilles Salbert

ACS Chem Biol 2017 03 13;12(3):654-663. Epub 2017 Jan 13.

Université Rennes 1 , F-35042 Rennes, France.

View Article

Download full-text PDF

 Source
http://dx.doi.org/10.1021/acschembio.6b00593DOI Listing
March 2017

The Sodium-Glucose Cotransporter 2 Inhibitor Dapagliflozin Prevents Cardiomyopathy in a Diabetic Lipodystrophic Mouse Model.

Authors:
Michael Joubert Benoît Jagu David Montaigne Xavier Marechal Angela Tesse Audrey Ayer Lucile Dollet Cédric Le May Gilles Toumaniantz Alain Manrique Flavien Charpentier Bart Staels Jocelyne Magré Bertrand Cariou Xavier Prieur

Diabetes 2017 04 4;66(4):1030-1040. Epub 2017 Jan 4.

L'Institut du Thorax, INSERM, CNRS, Université de Nantes, Nantes, France

View Article

Download full-text PDF

 Source
http://dx.doi.org/10.2337/db16-0733DOI Listing
April 2017

DHA-derived oxylipins, neuroprostanes and protectins, differentially and dose-dependently modulate the inflammatory response in human macrophages: Putative mechanisms through PPAR activation.

Authors:
Rémy Bosviel Laurie Joumard-Cubizolles Giulia Chinetti-Gbaguidi Dominique Bayle Corinne Copin Nathalie Hennuyer Isabelle Duplan Bart Staels Giuseppe Zanoni Alessio Porta Laurence Balas Jean-Marie Galano Camille Oger Andrzej Mazur Thierry Durand Cécile Gladine

Free Radic Biol Med 2017 02 14;103:146-154. Epub 2016 Dec 14.

INRA, UMR 1019, UNH, CRNH Auvergne, F-63000 Clermont-Ferrand, France; Clermont Université, Université d'Auvergne, Unité de Nutrition Humaine, BP 10448, F-63000 Clermont-Ferrand, France. Electronic address:

View Article

Download full-text PDF

 Source
http://dx.doi.org/10.1016/j.freeradbiomed.2016.12.018DOI Listing
February 2017

Impaired histone deacetylases 5 and 6 expression mimics the effects of obesity and hypoxia on adipocyte function.

Authors:
Julien Bricambert Dimitri Favre Saška Brajkovic Amélie Bonnefond Raphael Boutry Roberto Salvi Valérie Plaisance Mohamed Chikri Giulia Chinetti-Gbaguidi Bart Staels Vittorio Giusti Robert Caiazzo François Pattou Gérard Waeber Philippe Froguel Amar Abderrahmani

Mol Metab 2016 12 5;5(12):1200-1207. Epub 2016 Oct 5.

Univ. Lille, CNRS, Institut Pasteur de Lille, UMR 8199 - EGID, F-59000 Lille, France; Department of Genomic of Common Disease, Imperial College London, UK. Electronic address:

View Article

Download full-text PDF

 Source
http://dx.doi.org/10.1016/j.molmet.2016.09.011DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5123204PMC
December 2016

Intestinal bile acid receptors are key regulators of glucose homeostasis.

Authors:
Mohamed-Sami Trabelsi Sophie Lestavel Bart Staels Xavier Collet

Proc Nutr Soc 2017 08 16;76(3):192-202. Epub 2016 Nov 16.

Institut National de la Santé et de la Recherche Médicale, U1048, Université Paul Sabatier, UPS, Institut des Maladies Métaboliques et Cardiovasculaires (I2MC),CHU Rangueil,1 Avenue Jean Poulhès,BP84225, 31432 Toulouse,Cedex 4,France.

View Article

Download full-text PDF

 Source
http://dx.doi.org/10.1017/S0029665116002834DOI Listing
August 2017

PPARs in obesity-induced T2DM, dyslipidaemia and NAFLD.

Authors:
Barbara Gross Michal Pawlak Philippe Lefebvre Bart Staels

Nat Rev Endocrinol 2017 01 16;13(1):36-49. Epub 2016 Sep 16.

Université de Lille, INSERM, CHU Lille, Institut Pasteur de Lille, U1011-EGID, F-59000 Lille, France.

View Article

Download full-text PDF

 Source
http://dx.doi.org/10.1038/nrendo.2016.135DOI Listing
January 2017

Retrograde cholesterol transport in the human Caco-2/TC7 cell line: a model to study trans-intestinal cholesterol excretion in atherogenic and diabetic dyslipidemia.

Authors:
Camille Dugardin Olivier Briand Véronique Touche Marleen Schonewille François Moreau Cédric Le May Albert K Groen Bart Staels Sophie Lestavel

Acta Diabetol 2017 Feb 28;54(2):191-199. Epub 2016 Oct 28.

Inserm, CHU Lille, Institut Pasteur de Lille, U1011 - EGID, Univ. Lille, 59000, Lille, France.

View Article

Download full-text PDF

 Source
http://dx.doi.org/10.1007/s00592-016-0936-zDOI Listing
February 2017

Omentin-1, epicardial fat and coronary artery disease.

Authors:
Cedric Klein Sandro Ninni Augustin Coisne Bart Staels David Montaigne

Atherosclerosis 2016 12 13;255:224-225. Epub 2016 Oct 13.

CHU de Lille, Department of Echocardiography and Cardiovascular explorations, Lille, France; European Genomic Institute for Diabetes (E.G.I.D), FR 3508, F-59000, Lille, France; Univ Lille, F-59000, Lille, France; Inserm UMR 1011, F-59000, Lille, France; Institut Pasteur de Lille, F-59000, Lille, France.

View Article

Download full-text PDF

 Source
http://dx.doi.org/10.1016/j.atherosclerosis.2016.10.021DOI Listing
December 2016

A Mathematical Model of the Liver Circadian Clock Linking Feeding and Fasting Cycles to Clock Function.

Authors:
Aurore Woller Hélène Duez Bart Staels Marc Lefranc

Cell Rep 2016 10;17(4):1087-1097

University of Lille, CNRS, UMR 8523-PhLAM-Physique des Lasers, Atomes et Molécules, 59000 Lille, France. Electronic address:

View Article

Download full-text PDF

 Source
http://dx.doi.org/10.1016/j.celrep.2016.09.060DOI Listing
October 2016

Farnesoid X Receptor and Its Ligands Inhibit the Function of Platelets.

Authors:
Leonardo A Moraes Amanda J Unsworth Sakthivel Vaiyapuri Marfoua S Ali Parvathy Sasikumar Tanya Sage Gagan D Flora Alex P Bye Neline Kriek Emilie Dorchies Olivier Molendi-Coste David Dombrowicz Bart Staels David Bishop-Bailey Jonathan M Gibbins

Arterioscler Thromb Vasc Biol 2016 12 6;36(12):2324-2333. Epub 2016 Oct 6.

Institute for Cardiovascular and Metabolic Research, School of Biological Sciences, Harborne Building, University of Reading, Reading, Berkshire, RG6 6AS, UK.

View Article

Download full-text PDF

 Source
http://dx.doi.org/10.1161/ATVBAHA.116.308093DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5144997PMC
December 2016

Synchronized human skeletal myotubes of lean, obese and type 2 diabetic patients maintain circadian oscillation of clock genes.

Authors:
Jan Hansen Silvie Timmers Esther Moonen-Kornips Helene Duez Bart Staels Matthijs K C Hesselink Patrick Schrauwen

Sci Rep 2016 10 19;6:35047. Epub 2016 Oct 19.

Department of Human Biology and Human Movement Sciences, NUTRIM School for Nutrition and Translational Research in Metabolism, Maastricht University Medical Center, Maastricht, The Netherlands.

View Article

Download full-text PDF

 Source
http://dx.doi.org/10.1038/srep35047DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5069469PMC
October 2016