Publications by authors named "Bart Staels"

100Publications

Perspectives on the use of super-enhancers as a defining feature of cell/tissue-identity genes.

Epigenomics 2020 Apr 12;12(8):715-723. Epub 2020 May 12.

University of Lille, Inserm, CHU Lille, Institut Pasteur de Lille, U1011-EGID, Lille F-59000 Lille, France.

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http://dx.doi.org/10.2217/epi-2019-0290DOI Listing
April 2020

Plasma BCAA Changes in Patients With NAFLD Are Sex Dependent.

J Clin Endocrinol Metab 2020 Jul;105(7)

University of Lille, Inserm, CHU Lille, Institut Pasteur de Lille, U1011-EGID, Lille, France.

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http://dx.doi.org/10.1210/clinem/dgaa175DOI Listing
July 2020

Electrothermal patches driving the transdermal delivery of insulin.

Nanoscale Horiz 2020 Apr 2;5(4):663-670. Epub 2020 Jan 2.

Univ. Lille, CNRS, Centrale Lille, Yncréa ISEN, Univ. Polytechnique Hauts-de-France, UMR 8520 - IEMN, F-59000 Lille, France.

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http://dx.doi.org/10.1039/c9nh00576eDOI Listing
April 2020

Pirfenidone Is an Agonistic Ligand for PPARα and Improves NASH by Activation of SIRT1/LKB1/pAMPK.

Hepatol Commun 2020 Mar 16;4(3):434-449. Epub 2020 Jan 16.

Department of Molecular Biology and Genomics Institute for Molecular Biology in Medicine and Gene Therapy Health Sciences University Center University of Guadalajara Guadalajara México.

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http://dx.doi.org/10.1002/hep4.1474DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7049672PMC
March 2020

Microbiome Modulation of the Host Adaptive Immunity through Bile Acid Modification.

Cell Metab 2020 Mar;31(3):445-447

Univ. Lille, Inserm, CHU Lille, Institut Pasteur de Lille, U1011- EGID, 59000 Lille, France.

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http://dx.doi.org/10.1016/j.cmet.2020.02.006DOI Listing
March 2020

Analysis of the association of MPO and MMP-9 with stroke severity and outcome: Cohort study.

Neurology 2020 Jul 28;95(1):e97-e108. Epub 2020 Feb 28.

From the Departments of Neurology (I.M., A.-M.M., C.C., D.L.) and Medical Pharmacology (S.G., R.B.), Degenerative and Vascular Cognitive Disorders, University Hospital CHU Lille, Inserm U1171, University of Lille, France; Department of Human Neurosciences (I.M.), "Sapienza" University of Rome, Italy; and European Genomic Institute for Diabetes (M.T., A.D., S.S., A.T., E.V., B.S.), University Hospital CHU Lille, Inserm U1011, Institut Pasteur of Lille, University of Lille, France.

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http://dx.doi.org/10.1212/WNL.0000000000009179DOI Listing
July 2020

Bile acids associate with glucose metabolism, but do not predict conversion from impaired fasting glucose to diabetes.

Metabolism 2020 02 27;103:154042. Epub 2019 Nov 27.

L'institut du thorax, Department of Endocrinology, CIC 1413 INSERM, CHU Nantes, Nantes, France; L'institut du thorax, INSERM, CNRS, Univ. Nantes, CHU Nantes, Nantes, France. Electronic address:

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http://dx.doi.org/10.1016/j.metabol.2019.154042DOI Listing
February 2020

Synthesis of benzopyran derivatives as PPARα and/or PPARγ activators.

Bioorg Med Chem 2019 12 30;27(24):115162. Epub 2019 Oct 30.

Departamento de Farmacología, Universidad de Valencia, Valencia, Spain; Instituto de Investigación Sanitaria - INCLIVA, Hospital Clínico Universitario de Valencia, Valencia 46010, Spain. Electronic address:

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http://dx.doi.org/10.1016/j.bmc.2019.115162DOI Listing
December 2019

Near-infrared light activatable hydrogels for metformin delivery.

Nanoscale 2019 Aug;11(34):15810-15820

Univ. Lille, CNRS, Centrale Lille, ISEN, Univ. Valenciennes, UMR 8520 - IEMN, F-59000 Lille, France.

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http://dx.doi.org/10.1039/c9nr02707fDOI Listing
August 2019

Mathematical models converge on PGC1α as the key metabolic integrator of SIRT1 and AMPK regulation of the circadian clock.

Proc Natl Acad Sci U S A 2019 07 25;116(27):13171-13172. Epub 2019 Jun 25.

University of Lille, CNRS, UMR 8523, PhLAM-Physique des Lasers Atomes et Molécules, F-59000 Lille, France;

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http://dx.doi.org/10.1073/pnas.1907751116DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6613102PMC
July 2019

Understanding lipid metabolism through hepatic steat-omics.

Nat Rev Endocrinol 2019 06;15(6):321-322

INSERM UMR1011, European Genomic Institute for Diabetes, University of Lille, CHU Lille, Institut Pasteur de Lille, Lille, France.

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http://dx.doi.org/10.1038/s41574-019-0203-9DOI Listing
June 2019

The circadian clock and liver function in health and disease.

J Hepatol 2019 07 28;71(1):200-211. Epub 2019 Mar 28.

Institut de Recherche sur les Maladies Virales et Hépatiques INSERM, UMR 1110, Université de Strasbourg, Strasbourg, France; Pôle Hépato-Digestif, Institut Hospitalo-Universitaire, Hôpitaux Universitaires de Strasbourg, Strasbourg, France. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S01688278193019
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http://dx.doi.org/10.1016/j.jhep.2019.03.020DOI Listing
July 2019

Liver-specific RORα deletion does not affect the metabolic susceptibility to western style diet feeding.

Mol Metab 2019 05 9;23:82-87. Epub 2019 Mar 9.

Wallenberg Laboratory, Department of Molecular and Clinical Medicine, Sahlgrenska Academy, University of Gothenburg, 413 45, Gothenburg, Sweden; Novo Nordisk Foundation Center for Basic Metabolic Research and Section for Metabolic Receptology and Enteroendocrinology, Faculty of Health Sciences, University of Copenhagen, Copenhagen, 2200, Denmark. Electronic address:

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http://dx.doi.org/10.1016/j.molmet.2019.02.010DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6479759PMC
May 2019

ATF6α downregulation of PPARα promotes lipotoxicity-induced tubulointerstitial fibrosis.

Kidney Int 2019 03 11;95(3):577-589. Epub 2019 Jan 11.

Division of Chronic Kidney Disease Pathophysiology, The University of Tokyo Graduate School of Medicine, Tokyo, Japan. Electronic address:

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http://dx.doi.org/10.1016/j.kint.2018.09.023DOI Listing
March 2019

Time to Check the Clock in Cardiovascular Research and Medicine.

Circ Res 2018 08;123(6):648-650

From the European Genomic Institute for Diabetes, University of Lille, France (D.M., B.S.).

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http://dx.doi.org/10.1161/CIRCRESAHA.118.313543DOI Listing
August 2018

Circulating PCSK9 levels are not associated with the severity of hepatic steatosis and NASH in a high-risk population.

Atherosclerosis 2018 11 13;278:82-90. Epub 2018 Sep 13.

L'institut du thorax, Department of Endocrinology, CIC 1413 INSERM, CHU Nantes, Nantes, France; L'institut du thorax, INSERM, CNRS, CHU Nantes, Nantes, France. Electronic address:

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http://dx.doi.org/10.1016/j.atherosclerosis.2018.09.008DOI Listing
November 2018

Keratinocyte Expression of A20/TNFAIP3 Controls Skin Inflammation Associated with Atopic Dermatitis and Psoriasis.

J Invest Dermatol 2019 01 14;139(1):135-145. Epub 2018 Aug 14.

Université de Lille, INSERM, Centre Hospitalier Universitaire de Lille, Institut Pasteur de Lille, U1011-EGID, Lille, France. Electronic address:

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http://dx.doi.org/10.1016/j.jid.2018.06.191DOI Listing
January 2019

MuscleJ: a high-content analysis method to study skeletal muscle with a new Fiji tool.

Skelet Muscle 2018 08 6;8(1):25. Epub 2018 Aug 6.

Experimental Neuropathology Unit, Infection and Epidemiology Department, Institut Pasteur, 25, rue du Docteur Roux, 75015, Paris, France.

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http://dx.doi.org/10.1186/s13395-018-0171-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6091189PMC
August 2018

Peri-operative acute kidney injury upon cardiac surgery time-of-day.

Int J Cardiol 2018 Dec 19;272:54-59. Epub 2018 Jul 19.

CHU Lille, Department of Clinical Physiology and Echocardiography, Heart Valve Clinic, F-59000 Lille, France; European Genomic Institute for Diabetes (E.G.I.D), Univ Lille, F-59000 Lille, France; Inserm, U1011, F-59000 Lille, France; Institut Pasteur de Lille, F-59019 Lille, France. Electronic address:

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http://dx.doi.org/10.1016/j.ijcard.2018.07.081DOI Listing
December 2018

Molecular Actions of PPARα in Lipid Metabolism and Inflammation.

Endocr Rev 2018 10;39(5):760-802

Department of Biomolecular Medicine, Ghent University, Ghent, Belgium.

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https://academic.oup.com/edrv/article/39/5/760/5055100
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http://dx.doi.org/10.1210/er.2018-00064DOI Listing
October 2018

Circadian misalignment induces fatty acid metabolism gene profiles and compromises insulin sensitivity in human skeletal muscle.

Proc Natl Acad Sci U S A 2018 07 9;115(30):7789-7794. Epub 2018 Jul 9.

Department of Nutrition and Movement Sciences, School for Nutrition and Translational Research in Metabolism, Maastricht University Medical Center, 6200 MD Maastricht, The Netherlands;

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http://dx.doi.org/10.1073/pnas.1722295115DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6065021PMC
July 2018

Daytime variations in perioperative myocardial injury - Authors' reply.

Lancet 2018 05 24;391(10135):2106. Epub 2018 May 24.

University of Lille, EGID, F-59000 Lille, France; Inserm, U1011, F-Lille, France; University Hospital CHU Lille, Lille, France; Institut Pasteur de Lille, Lille, France.

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http://dx.doi.org/10.1016/S0140-6736(18)30758-XDOI Listing
May 2018

Alternative macrophages in atherosclerosis: not always protective!

J Clin Invest 2018 03 19;128(3):910-912. Epub 2018 Feb 19.

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http://dx.doi.org/10.1172/JCI120123DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5824921PMC
March 2018

Organizing combinatorial transcription factor recruitment at cis-regulatory modules.

Transcription 2018 28;9(4):233-239. Epub 2017 Nov 28.

a Université de Lille - Inserm - Chru de Lille, Institut Pasteur de Lille , U1011- EGID, F-59000 Lille , France.

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http://dx.doi.org/10.1080/21541264.2017.1394424DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6104691PMC
October 2018

Risperidone-induced metabolic dysfunction is attenuated by Curcuma longa extract administration in mice.

Metab Brain Dis 2018 02 16;33(1):63-77. Epub 2017 Oct 16.

Inserm, CHU Lille, U1171 - Degenerative & Vascular Cognitive Disorders, University of Lille, F-59000, Lille, France.

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http://link.springer.com/10.1007/s11011-017-0133-y
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http://dx.doi.org/10.1007/s11011-017-0133-yDOI Listing
February 2018

Fasting the Microbiota to Improve Metabolism?

Cell Metab 2017 Oct;26(4):584-585

European Genomic Institute for Diabetes (E.G.I.D), University of Lille, EGID, 59000 Lille, France; INSERM UMR 1011, 59000 Lille, France; Institut Pasteur de Lille, 59000 Lille, France; University Hospital CHU Lille, 59000 Lille, France. Electronic address:

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http://dx.doi.org/10.1016/j.cmet.2017.09.013DOI Listing
October 2017

Bile Acid Alterations Are Associated With Insulin Resistance, but Not With NASH, in Obese Subjects.

J Clin Endocrinol Metab 2017 10;102(10):3783-3794

Université Lille, INSERM, Centre Hospitalier Universitaire de Lille, Institut Pasteur de Lille, U1011-European Genomic Institute for Diabetes, F-59000 Lille, France.

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http://dx.doi.org/10.1210/jc.2017-01397DOI Listing
October 2017

Ffar2 expression regulates leukaemic cell growth in vivo.

Br J Cancer 2017 Oct 5;117(9):1336-1340. Epub 2017 Sep 5.

Metabolism and Nutrition Research Group, Louvain Drug Research Institute, Université Catholique de Louvain, Avenue Mounier 73, Box B1.73.11, Brussels 1200, Belgium.

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http://dx.doi.org/10.1038/bjc.2017.307DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5672929PMC
October 2017

Circadian control of metabolism and pathological consequences of clock perturbations.

Biochimie 2017 Dec 2;143:42-50. Epub 2017 Aug 2.

Univ. Lille, Inserm, CHU Lille, Institut Pasteur de Lille, U1011 - EGID, F-59000, Lille, France. Electronic address:

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http://dx.doi.org/10.1016/j.biochi.2017.07.017DOI Listing
December 2017

Anti-diabetic activity of fused PPARγ-SIRT1 ligands with limited body-weight gain by mimicking calorie restriction and decreasing SGK1 expression.

Eur J Med Chem 2017 Sep 12;137:310-326. Epub 2017 Jun 12.

Univ. Lille, Inserm, CHU Lille, UMR-S 1172 - JPArc - Centre de Recherche Jean-Pierre AUBERT Neurosciences et Cancer, F-59000 Lille, France. Electronic address:

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http://dx.doi.org/10.1016/j.ejmech.2017.06.006DOI Listing
September 2017

Cardiovascular Protection by Sodium Glucose Cotransporter 2 Inhibitors: Potential Mechanisms.

Authors:
Bart Staels

Am J Cardiol 2017 07 30;120(1S):S28-S36. Epub 2017 May 30.

Université Lille, INSERM, CHU Lille, Institut Pasteur de Lille, U1011-EGID, Lille, France. Electronic address:

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http://dx.doi.org/10.1016/j.amjcard.2017.05.013DOI Listing
July 2017

Mitochondria and endoplasmic reticulum: Targets for a better insulin sensitivity in skeletal muscle?

Biochim Biophys Acta Mol Cell Biol Lipids 2017 Sep 18;1862(9):901-916. Epub 2017 May 18.

Univ. Lille, Inserm, CHU Lille, Institut Pasteur de Lille, U1011 - EGID, F-59000, Lille, France. Electronic address:

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http://dx.doi.org/10.1016/j.bbalip.2017.05.011DOI Listing
September 2017

Cardiovascular Protection by Sodium Glucose Cotransporter 2 Inhibitors: Potential Mechanisms.

Authors:
Bart Staels

Am J Med 2017 Jun;130(6S):S30-S39

Université Lille, INSERM, CHU Lille, Institut Pasteur de Lille, U1011-EGID, Lille, France. Electronic address:

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http://dx.doi.org/10.1016/j.amjmed.2017.04.009DOI Listing
June 2017

Human Alternative Macrophages Populate Calcified Areas of Atherosclerotic Lesions and Display Impaired RANKL-Induced Osteoclastic Bone Resorption Activity.

Circ Res 2017 Jun 24;121(1):19-30. Epub 2017 Apr 24.

From the Université de Lille, Inserm, CHU Lille, Institut Pasteur de Lille, U1011, EGID, Lille, France (G.C.-G., M.D., M.R., M.V., C.C., M.F., J.V., B.D., L.B., C.Z., S.S., J.E., B.S.); University of Côte d'Azur, CHU, Inserm, CNRS, IRCAN, Nice, France (G.C.-G.); Inserm U1088, University of Picardie Jules Verne, and Amiens University Hospital, Amiens, France (L.L.); CHU Lille, Lille, France (S.H.); Division of Nephrology, Ambroise Paré University Hospital, AP-HP, Boulogne-Billancourt (Z.A.M.); and INSERM U1018, Team 5, CESP, UVSQ, Paris-Saclay University, Villejuif/Paris, France (Z.A.M.).

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http://dx.doi.org/10.1161/CIRCRESAHA.116.310262DOI Listing
June 2017

Leptin induces osteoblast differentiation of human valvular interstitial cells via the Akt and ERK pathways.

Acta Diabetol 2017 Jun 18;54(6):551-560. Epub 2017 Mar 18.

European Genomic Institute for Diabetes (E.G.I.D.), FR 3508, UNIV LILLE, Inserm UMR 1011, 59000, Lille, France.

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http://dx.doi.org/10.1007/s00592-017-0980-3DOI Listing
June 2017

Bile Acid Control of Metabolism and Inflammation in Obesity, Type 2 Diabetes, Dyslipidemia, and Nonalcoholic Fatty Liver Disease.

Gastroenterology 2017 05 15;152(7):1679-1694.e3. Epub 2017 Feb 15.

Univ. Lille, Inserm, CHU Lille, Institut Pasteur de Lille, U1011 - EGID, F-59000 Lille, France. Electronic address:

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http://dx.doi.org/10.1053/j.gastro.2017.01.055DOI Listing
May 2017

Anacetrapib, but not evacetrapib, impairs endothelial function in CETP-transgenic mice in spite of marked HDL-C increase.

Atherosclerosis 2017 02 16;257:186-194. Epub 2017 Jan 16.

Center for Molecular Cardiology, Campus Schlieren, University of Zürich, Switzerland; University Heart Center, Cardiology, University Hospital Zürich, Switzerland. Electronic address:

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http://dx.doi.org/10.1016/j.atherosclerosis.2017.01.011DOI Listing
February 2017

DHA-derived oxylipins, neuroprostanes and protectins, differentially and dose-dependently modulate the inflammatory response in human macrophages: Putative mechanisms through PPAR activation.

Free Radic Biol Med 2017 02 14;103:146-154. Epub 2016 Dec 14.

INRA, UMR 1019, UNH, CRNH Auvergne, F-63000 Clermont-Ferrand, France; Clermont Université, Université d'Auvergne, Unité de Nutrition Humaine, BP 10448, F-63000 Clermont-Ferrand, France. Electronic address:

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http://dx.doi.org/10.1016/j.freeradbiomed.2016.12.018DOI Listing
February 2017

Impaired histone deacetylases 5 and 6 expression mimics the effects of obesity and hypoxia on adipocyte function.

Mol Metab 2016 12 5;5(12):1200-1207. Epub 2016 Oct 5.

Univ. Lille, CNRS, Institut Pasteur de Lille, UMR 8199 - EGID, F-59000 Lille, France; Department of Genomic of Common Disease, Imperial College London, UK. Electronic address:

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http://dx.doi.org/10.1016/j.molmet.2016.09.011DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5123204PMC
December 2016

Intestinal bile acid receptors are key regulators of glucose homeostasis.

Proc Nutr Soc 2017 08 16;76(3):192-202. Epub 2016 Nov 16.

Institut National de la Santé et de la Recherche Médicale, U1048, Université Paul Sabatier, UPS, Institut des Maladies Métaboliques et Cardiovasculaires (I2MC),CHU Rangueil,1 Avenue Jean Poulhès,BP84225, 31432 Toulouse,Cedex 4,France.

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http://dx.doi.org/10.1017/S0029665116002834DOI Listing
August 2017

PPARs in obesity-induced T2DM, dyslipidaemia and NAFLD.

Nat Rev Endocrinol 2017 01 16;13(1):36-49. Epub 2016 Sep 16.

Université de Lille, INSERM, CHU Lille, Institut Pasteur de Lille, U1011-EGID, F-59000 Lille, France.

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http://dx.doi.org/10.1038/nrendo.2016.135DOI Listing
January 2017

Omentin-1, epicardial fat and coronary artery disease.

Atherosclerosis 2016 12 13;255:224-225. Epub 2016 Oct 13.

CHU de Lille, Department of Echocardiography and Cardiovascular explorations, Lille, France; European Genomic Institute for Diabetes (E.G.I.D), FR 3508, F-59000, Lille, France; Univ Lille, F-59000, Lille, France; Inserm UMR 1011, F-59000, Lille, France; Institut Pasteur de Lille, F-59000, Lille, France.

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http://dx.doi.org/10.1016/j.atherosclerosis.2016.10.021DOI Listing
December 2016

A Mathematical Model of the Liver Circadian Clock Linking Feeding and Fasting Cycles to Clock Function.

Cell Rep 2016 10;17(4):1087-1097

University of Lille, CNRS, UMR 8523-PhLAM-Physique des Lasers, Atomes et Molécules, 59000 Lille, France. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2016.09.060DOI Listing
October 2016

Farnesoid X Receptor and Its Ligands Inhibit the Function of Platelets.

Arterioscler Thromb Vasc Biol 2016 12 6;36(12):2324-2333. Epub 2016 Oct 6.

Institute for Cardiovascular and Metabolic Research, School of Biological Sciences, Harborne Building, University of Reading, Reading, Berkshire, RG6 6AS, UK.

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http://dx.doi.org/10.1161/ATVBAHA.116.308093DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5144997PMC
December 2016

Synchronized human skeletal myotubes of lean, obese and type 2 diabetic patients maintain circadian oscillation of clock genes.

Sci Rep 2016 10 19;6:35047. Epub 2016 Oct 19.

Department of Human Biology and Human Movement Sciences, NUTRIM School for Nutrition and Translational Research in Metabolism, Maastricht University Medical Center, Maastricht, The Netherlands.

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http://dx.doi.org/10.1038/srep35047DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5069469PMC
October 2016