Publications by authors named "Bart P Braeckman"

70Publications

Phenotypic Screening in as a Tool for the Discovery of New Geroprotective Drugs.

Pharmaceuticals (Basel) 2020 Jul 25;13(8). Epub 2020 Jul 25.

Laboratory of Aging Physiology and Molecular Evolution, Department of Biology, Ghent University, 9000 Ghent, Belgium.

View Article and Find Full Text PDF
July 2020

DAF-16/FoxO in and Its Role in Metabolic Remodeling.

Cells 2020 01 2;9(1). Epub 2020 Jan 2.

Laboratory of Aging Physiology and Molecular Evolution, Department of Biology, Ghent University, 9000 Ghent, Belgium.

View Article and Find Full Text PDF
January 2020

The nutritional requirements of .

Genes Nutr 2019 6;14:15. Epub 2019 May 6.

Department of Biology, Laboratory of Aging Physiology and Molecular Evolution, Ghent University, 9000 Ghent, Belgium.

View Article and Find Full Text PDF
May 2019

Assessment of graft perfusion and oxygenation for improved outcome in esophageal cancer surgery: Protocol for a single-center prospective observational study.

Medicine (Baltimore) 2018 Sep;97(38):e12073

Department of Gastrointestinal Surgery Department of Electronics and Information Systems Department of Aging Physiology and Molecular Evolution Department of Pathology Department of Anaesthesiology, Ghent University Hospital/Ghent University, Ghent, Belgium.

View Article and Find Full Text PDF
September 2018

Bioassay-guided isolation of three anthelmintic compounds from Warburgia ugandensis Sprague subspecies ugandensis, and the mechanism of action of polygodial.

Int J Parasitol 2018 09 18;48(11):833-844. Epub 2018 Jul 18.

Department of Biology, Animal Physiology and Neurobiology Section, KU Leuven, Naamsestraat 59, Box 2465, 3000 Leuven, Belgium.

View Article and Find Full Text PDF
September 2018

Multiple Molecular Mechanisms Rescue mtDNA Disease in C. elegans.

Cell Rep 2018 03;22(12):3115-3125

Department of Pathology and Laboratory Medicine, Children's Hospital of Philadelphia, PA 19104, USA. Electronic address:

View Article and Find Full Text PDF
March 2018

CBP-1 Acts in GABAergic Neurons to Double Life Span in Axenically Cultured Caenorhabditis elegans.

J Gerontol A Biol Sci Med Sci 2019 07;74(8):1198-1205

Laboratory of Aging Physiology and Molecular Evolution, Biology Department, Ghent University, Belgium.

View Article and Find Full Text PDF
July 2019

Changes of Protein Turnover in Aging .

Mol Cell Proteomics 2017 09 5;16(9):1621-1633. Epub 2017 Jul 5.

From the ‡Laboratory for Aging Physiology and Molecular Evolution, Biology Department, Ghent University, K.L. Ledeganckstraat 35, 9000 Ghent Belgium;

View Article and Find Full Text PDF
September 2017

Single swim sessions in C. elegans induce key features of mammalian exercise.

BMC Biol 2017 04 10;15(1):30. Epub 2017 Apr 10.

Department of Molecular Biology and Biochemistry, Nelson Biological Laboratories, Rutgers, The State University of New Jersey, Piscataway, NJ, USA.

View Article and Find Full Text PDF
April 2017

Unbiased RNA Shotgun Metagenomics in Social and Solitary Wild Bees Detects Associations with Eukaryote Parasites and New Viruses.

PLoS One 2016 22;11(12):e0168456. Epub 2016 Dec 22.

Laboratory of Molecular Entomology and Bee Pathology, Department of Biochemistry and Microbiology, Faculty of Sciences, Ghent University, Ghent, Belgium.

View Article and Find Full Text PDF
July 2017

Globin-based redox signaling.

Worm 2016 29;5(3):e1184390. Epub 2016 Apr 29.

Biology Department, Ghent University , Ghent, Belgium.

View Article and Find Full Text PDF
April 2016

Proteome-wide Changes in Protein Turnover Rates in C. elegans Models of Longevity and Age-Related Disease.

Cell Rep 2016 09;16(11):3041-3051

Center for Molecular Medicine, Molecular Cancer Research Section, University Medical Center Utrecht, Universiteitsweg 100, 3584 CG Utrecht, the Netherlands. Electronic address:

View Article and Find Full Text PDF
September 2016

FOXO/DAF-16 Activation Slows Down Turnover of the Majority of Proteins in C. elegans.

Cell Rep 2016 09;16(11):3028-3040

Laboratory for Aging Physiology and Molecular Evolution, Biology Department, Ghent University, Proeftuinstraat 86 N1, 9000 Ghent, Belgium. Electronic address:

View Article and Find Full Text PDF
September 2016

In Vivo Detection of Reactive Oxygen Species and Redox Status in Caenorhabditis elegans.

Antioxid Redox Signal 2016 10 12;25(10):577-92. Epub 2016 Sep 12.

1 Biology Department, Ghent University , Ghent, Belgium .

View Article and Find Full Text PDF
October 2016

Increased Protein Stability and Decreased Protein Turnover in the Caenorhabditis elegans Ins/IGF-1 daf-2 Mutant.

J Gerontol A Biol Sci Med Sci 2016 12 10;71(12):1553-1559. Epub 2016 Feb 10.

Laboratory for Aging Physiology and Molecular Evolution, Department of Biology, Ghent University, Belgium.

View Article and Find Full Text PDF
December 2016

Life history trade-offs imposed by dragline use in two money spiders.

J Exp Biol 2016 Jan 23;219(Pt 1):26-30. Epub 2015 Nov 23.

Ghent University, Department of Biology, Laboratory of Ageing Physiology and Molecular Evolution, Proeftuinstraat 86 N1, Gent 9000, Belgium.

View Article and Find Full Text PDF
January 2016

Iron-Starvation-Induced Mitophagy Mediates Lifespan Extension upon Mitochondrial Stress in C. elegans.

Curr Biol 2015 Jul 2;25(14):1810-22. Epub 2015 Jul 2.

Institute for Clinical Chemistry and Laboratory Diagnostic, Medical Faculty of the Heinrich Heine University, 40225 Düsseldorf, Germany; IUF-Leibniz Research Institute for Environmental Medicine, 40225 Düsseldorf, Germany; Department of Biomedicine and Prevention, University of Rome Tor Vergata, 00133 Rome, Italy. Electronic address:

View Article and Find Full Text PDF
July 2015

Metabolic profiling of a transgenic Alzheimer model.

Metabolomics 2015;11(2):477-486. Epub 2014 Jul 30.

Metabolomics Australia, School of Botany, University of Melbourne, Melbourne, Australia.

View Article and Find Full Text PDF
July 2014

Germline quality control: eEF2K stands guard to eliminate defective oocytes.

Dev Cell 2014 Mar 27;28(5):561-572. Epub 2014 Feb 27.

Department of Pharmacology, Rutgers The State University of New Jersey - Robert Wood Johnson Medical School, Piscataway, New Jersey, 08854, USA.

View Article and Find Full Text PDF
March 2014

Mitochondrial efficiency is increased in axenically cultured Caenorhabditis elegans.

Exp Gerontol 2014 Aug 18;56:26-36. Epub 2014 Feb 18.

Department of Biology, Ghent University, Proeftuinstraat 86, 9000 Gent, Belgium. Electronic address:

View Article and Find Full Text PDF
August 2014

GLB-13 is associated with oxidative stress resistance in Caenorhabditis elegans.

IUBMB Life 2013 May 18;65(5):423-34. Epub 2013 Mar 18.

Beijing Institute of Radiation Medicine, State Key Laboratory of Proteomics, Cognitive and Mental Health Research Center, Beijing, China.

View Article and Find Full Text PDF
May 2013

ROS in aging Caenorhabditis elegans: damage or signaling?

Oxid Med Cell Longev 2012 15;2012:608478. Epub 2012 Aug 15.

Laboratory for Aging Physiology and Molecular Evolution, Department of Biology, Ghent University, K. L. Ledeganckstraat 35, 9000 Ghent, Belgium.

View Article and Find Full Text PDF
January 2013

A simplified hydroethidine method for fast and accurate detection of superoxide production in isolated mitochondria.

Anal Biochem 2012 Apr 24;423(1):147-51. Epub 2012 Jan 24.

Laboratory for Aging Physiology and Molecular Evolution, Department of Biology, Ghent University, 9000 Ghent, Belgium.

View Article and Find Full Text PDF
April 2012

Exploring real-time in vivo redox biology of developing and aging Caenorhabditis elegans.

Free Radic Biol Med 2012 Mar 23;52(5):850-9. Epub 2011 Dec 23.

Laboratory for Aging Physiology and Molecular Evolution, Department of Biology, Ghent University, Ghent, Belgium.

View Article and Find Full Text PDF
March 2012

Increased life span from overexpression of superoxide dismutase in Caenorhabditis elegans is not caused by decreased oxidative damage.

Free Radic Biol Med 2011 Oct 31;51(8):1575-82. Epub 2011 Jul 31.

Institute of Healthy Ageing and Research Department of Genetics, Evolution and Environment, University College London, London WC1E 6BT, UK.

View Article and Find Full Text PDF
October 2011

Lack of metabolic ageing in the long-lived flatworm Schmidtea polychroa.

Exp Gerontol 2011 Sep 23;46(9):755-61. Epub 2011 Apr 23.

Laboratory for Ageing Physiology and Molecular Evolution, Biology Department, Ghent University, K.L. Ledeganckstraat 35, 9000 Ghent, Belgium.

View Article and Find Full Text PDF
September 2011

Globins in Caenorhabditis elegans.

IUBMB Life 2011 Mar;63(3):166-74

Department of Biomedical Sciences, University of Antwerp, Antwerp, Belgium.

View Article and Find Full Text PDF
March 2011

Protein metabolism and lifespan in Caenorhabditis elegans.

Adv Exp Med Biol 2010 ;694:81-107

Department of Biology, Ghent University, K.L. Ledeganckstraat 35, B-9000 Ghent, Belgium.

View Article and Find Full Text PDF
October 2010

Disruption of insulin signalling preserves bioenergetic competence of mitochondria in ageing Caenorhabditis elegans.

BMC Biol 2010 Jun 28;8:91. Epub 2010 Jun 28.

Department of Biology, Ghent University, K L Ledeganckstraat 35, Ghent B-9000, Belgium.

View Article and Find Full Text PDF
June 2010

Effects of sod gene overexpression and deletion mutation on the expression profiles of reporter genes of major detoxification pathways in Caenorhabditis elegans.

Exp Gerontol 2010 Aug 22;45(7-8):603-10. Epub 2010 Jan 22.

Laboratory for Aging Physiology and Molecular Evolution, Department of Biology, Ghent University, K.L. Ledeganckstraat 35, Ghent, Belgium.

View Article and Find Full Text PDF
August 2010

Demographic analysis reveals gradual senescence in the flatworm Macrostomum lignano.

Front Zool 2009 Jul 30;6:15. Epub 2009 Jul 30.

Nematology Unit, Department of Biology, Ghent University, Ledeganckstraat 35, 9000 Ghent, Belgium.

View Article and Find Full Text PDF
July 2009

Intermediary metabolism.

WormBook 2009 Feb 16:1-24. Epub 2009 Feb 16.

Biology Department, Ghent University, K.L.Ledeganckstraat 35, B-9000 Ghent, Belgium.

View Article and Find Full Text PDF
February 2009

Prooxidant activity of the superoxide dismutase (SOD)-mimetic EUK-8 in proliferating and growth-arrested Escherichia coli cells.

Free Radic Biol Med 2008 Sep 4;45(5):708-15. Epub 2008 Jun 4.

Department of Biology, Ghent University, Ledeganckstraat 35, B-9000 Ghent, Belgium.

View Article and Find Full Text PDF
September 2008

Testing the rate-of-living/oxidative damage theory of aging in the nematode model Caenorhabditis elegans.

Exp Gerontol 2007 Sep 20;42(9):845-51. Epub 2007 Feb 20.

Biology Department, Ghent University, K.L.Ledeganckstraat 35, B-9000 Ghent, Belgium.

View Article and Find Full Text PDF
September 2007

Genetic control of longevity in C. elegans.

Exp Gerontol 2007 Jan-Feb;42(1-2):90-8. Epub 2006 Jul 10.

Biology Department, Ghent University, K.L.Ledeganckstraat 35, B-9000 Ghent, Belgium.

View Article and Find Full Text PDF
October 2007

The dietary restriction effect in C. elegans and humans: is the worm a one-millimeter human?

Biogerontology 2006 Jun;7(3):127-33

Department of Biology, Ghent University, Ledeganckstraat 35, 9000 Ghent, Belgium.

View Article and Find Full Text PDF
June 2006

Metabolic rate is not reduced by dietary-restriction or by lowered insulin/IGF-1 signalling and is not correlated with individual lifespan in Drosophila melanogaster.

Exp Gerontol 2004 Aug;39(8):1137-43

Metabolic Research Centre and School of Biological Sciences, University of Wollongong, Wollongong, NSW 2522, Australia.

View Article and Find Full Text PDF
August 2004

Life extension via dietary restriction is independent of the Ins/IGF-1 signalling pathway in Caenorhabditis elegans.

Exp Gerontol 2003 Sep;38(9):947-54

Department of Biology, Ghent University, KL Ledeganckstraat 35, B-9000 Ghent, Belgium.

View Article and Find Full Text PDF
September 2003

Rebuttal to Van Voorhies: 'the influence of metabolic rate on longevity in the nematode Caenorhabditis elegans'.

Aging Cell 2002 Dec;1(2):89-90

Department of Biology, Ghent Universty, K.L. Ledeganckstraat 35, B-9000 Ghent, Belgium.

View Article and Find Full Text PDF
December 2002

Assessing metabolic activity in aging Caenorhabditis elegans: concepts and controversies.

Aging Cell 2002 Dec;1(2):82-8; discussion 102-3

Department of Biology, Ghent University, K.L. Ledeganckstraat 35, B-9000 Ghent, Belgium.

View Article and Find Full Text PDF
December 2002

No reduction of metabolic rate in food restricted Caenorhabditis elegans.

Exp Gerontol 2002 Dec;37(12):1359-69

Department of Biology, Ghent University, K.L. Ledeganckstraat 35, B-9000 Ghent, Belgium.

View Article and Find Full Text PDF
December 2002

No reduction of energy metabolism in Clk mutants.

Mech Ageing Dev 2002 Sep;123(11):1447-56

Department of Biology, Ghent University, K L Ledeganckstraat 35, B-9000, Ghent, Belgium.

View Article and Find Full Text PDF
September 2002

Assaying metabolic activity in ageing Caenorhabditis elegans.

Mech Ageing Dev 2002 Jan;123(2-3):105-19

Department of Biology, Ghent University, Ledeganckstraat 35, B-9000, Ghent, Belgium.

View Article and Find Full Text PDF
January 2002