Publications by authors named "Bart O Roep"

100Publications

Safety and feasibility of intradermal injection with tolerogenic dendritic cells pulsed with proinsulin peptide-for type 1 diabetes.

Lancet Diabetes Endocrinol 2020 06 5;8(6):470-472. Epub 2020 May 5.

Immunomodulation and Regenerative Cell Therapy, Leiden University Medical Center, 2333 ZA Leiden, Netherlands; Department of Diabetes Immunology, Diabetes and Metabolism Research Institute, Beckman Research Institute at City of Hope, Duarte, CA, USA.

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http://dx.doi.org/10.1016/S2213-8587(20)30104-2DOI Listing
June 2020

Anti-PD-1 Therapy-Associated Type 1 Diabetes in a Pediatric Patient With Relapsed Classical Hodgkin Lymphoma.

Diabetes Care 2020 Sep 2;43(9):2293-2295. Epub 2020 Jul 2.

Department of Diabetes Immunology, Diabetes & Metabolism Research Institute, City of Hope, Duarte, CA

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http://dx.doi.org/10.2337/dc20-0740DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7440902PMC
September 2020

GAD-alum immunotherapy in type 1 diabetes expands bifunctional Th1/Th2 autoreactive CD4 T cells.

Diabetologia 2020 Jun 4;63(6):1186-1198. Epub 2020 Apr 4.

Peter Gorer Department of Immunobiology, King's College London Faculty of Life Sciences and Medicine, 2nd Floor, Borough Wing, Guy's Hospital, London, SE1 9RT, UK.

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http://dx.doi.org/10.1007/s00125-020-05130-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7228993PMC
June 2020

Improving Clinical Islet Transplantation Outcomes.

Authors:
Bart O Roep

Diabetes Care 2020 Apr;43(4):698-700

Department of Diabetes Immunology, Diabetes & Metabolism Research Institute at the Beckman Research Institute, City of Hope National Medical Center, Duarte, CA

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http://dx.doi.org/10.2337/dci19-0080DOI Listing
April 2020

A viral link for type 1 diabetes.

Authors:
Bart O Roep

Nat Med 2019 12;25(12):1816-1818

Department of Diabetes Immunology, Diabetes & Metabolism Research Institute at the Beckman Research Institute, National Medical Center, City of Hope, Duarte, CA, USA.

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http://dx.doi.org/10.1038/s41591-019-0689-7DOI Listing
December 2019

Multidimensional analyses of proinsulin peptide-specific regulatory T cells induced by tolerogenic dendritic cells.

J Autoimmun 2020 02 24;107:102361. Epub 2019 Nov 24.

Department of Immunohematology and Blood Transfusion, Leiden University Medical Center, Leiden, Netherlands; Department of Diabetes Immunology, Diabetes & Metabolism Research Institute at the Beckman Research Institute, City of Hope, USA. Electronic address:

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http://dx.doi.org/10.1016/j.jaut.2019.102361DOI Listing
February 2020

Clinical and genetic correlates of islet-autoimmune signatures in juvenile-onset type 1 diabetes.

Diabetologia 2020 02 21;63(2):351-361. Epub 2019 Nov 21.

Department of Immunohaematology and Blood Transfusion, Leiden University Medical Center, Leiden, the Netherlands.

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http://dx.doi.org/10.1007/s00125-019-05032-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6946733PMC
February 2020

Intra-pancreatic tissue-derived mesenchymal stromal cells: a promising therapeutic potential with anti-inflammatory and pro-angiogenic profiles.

Stem Cell Res Ther 2019 11 15;10(1):322. Epub 2019 Nov 15.

Department of Translational Research and Cellular Therapeutics, Diabetes and Metabolism Research Institute, Beckman Research Institute of City of Hope, 1500 E. Duarte Rd, Duarte, CA, 91010, USA.

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http://dx.doi.org/10.1186/s13287-019-1435-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6858763PMC
November 2019

Activated Mesenchymal Stromal Cells Process and Present Antigens Regulating Adaptive Immunity.

Front Immunol 2019 3;10:694. Epub 2019 Apr 3.

Department of Diabetes Immunology, Diabetes and Metabolism Research Institute at the Beckman Research Institute of City of Hope, Duarte, CA, United States.

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https://www.frontiersin.org/article/10.3389/fimmu.2019.00694
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http://dx.doi.org/10.3389/fimmu.2019.00694DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6457321PMC
July 2020

Diabetes relief in mice by glucose-sensing insulin-secreting human α-cells.

Nature 2019 03 13;567(7746):43-48. Epub 2019 Feb 13.

Department of Genetic Medicine and Development, iGE3 and Centre Facultaire du Diabète, Faculty of Medicine, University of Geneva, Geneva, Switzerland.

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http://dx.doi.org/10.1038/s41586-019-0942-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6624841PMC
March 2019

Epitope Stealing as a Mechanism of Dominant Protection by HLA-DQ6 in Type 1 Diabetes.

Diabetes 2019 04 9;68(4):787-795. Epub 2019 Jan 9.

Department of Immunohematology and Blood Transfusion, Leiden University Medical Center, Leiden, the Netherlands

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http://diabetes.diabetesjournals.org/lookup/doi/10.2337/db18
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http://dx.doi.org/10.2337/db18-0501DOI Listing
April 2019

Bioluminescent reporter assay for monitoring ER stress in human beta cells.

Sci Rep 2018 12 10;8(1):17738. Epub 2018 Dec 10.

Departments of Cell and Chemical Biology, Leiden University Medical Center, Leiden, The Netherlands.

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http://www.nature.com/articles/s41598-018-36142-4
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http://dx.doi.org/10.1038/s41598-018-36142-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6288136PMC
December 2018

Antigen-based immune modulation therapy for type 1 diabetes: the era of precision medicine.

Lancet Diabetes Endocrinol 2019 01 24;7(1):65-74. Epub 2018 Oct 24.

Peter Gorer Department of Immunobiology, Faculty of Life Sciences & Medicine, King's College London, London, UK; King's Health Partners Institute of Diabetes, Obesity and Endocrinology, London, UK. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S22138587183010
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http://dx.doi.org/10.1016/S2213-8587(18)30109-8DOI Listing
January 2019

The challenge of modulating β-cell autoimmunity in type 1 diabetes.

Lancet Diabetes Endocrinol 2019 01 24;7(1):52-64. Epub 2018 Oct 24.

Peter Gorer Department of Immunobiology, Faculty of Life Sciences & Medicine, King's College London, London, UK; King's Health Partners Institute of Diabetes, Obesity and Endocrinology, London, UK.

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https://linkinghub.elsevier.com/retrieve/pii/S22138587183011
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http://dx.doi.org/10.1016/S2213-8587(18)30112-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7322790PMC
January 2019

Syntaxin 4 Expression in Pancreatic β-Cells Promotes Islet Function and Protects Functional β-Cell Mass.

Diabetes 2018 12 10;67(12):2626-2639. Epub 2018 Oct 10.

Department of Molecular and Cellular Endocrinology, Diabetes and Metabolism Research Institute of City of Hope, Duarte, CA

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http://diabetes.diabetesjournals.org/lookup/doi/10.2337/db18
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http://dx.doi.org/10.2337/db18-0259DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6245223PMC
December 2018

Islet stress, degradation and autoimmunity.

Diabetes Obes Metab 2018 09;20 Suppl 2:88-94

Department of Immunohematology and Blood bank Leiden University Medical Center, Leiden University Medical Center, Leiden, The Netherlands.

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http://doi.wiley.com/10.1111/dom.13387
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http://dx.doi.org/10.1111/dom.13387DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6174957PMC
September 2018

A Future for Autologous Hematopoietic Stem Cell Transplantation in Type 1 Diabetes.

Front Immunol 2018 6;9:690. Epub 2018 Apr 6.

Department of Diabetes Immunology, Diabetes & Metabolism Research Institute, Beckman Research Institute at the City of Hope, Duarte, CA, United States.

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http://dx.doi.org/10.3389/fimmu.2018.00690DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5904498PMC
June 2019

Abnormal islet sphingolipid metabolism in type 1 diabetes.

Diabetologia 2018 07 18;61(7):1650-1661. Epub 2018 Apr 18.

The Bartholin Institute, Department of Pathology, Rigshospitalet, Copenhagen Biocenter, Ole Maaløes Vej 5, 2200, Copenhagen N, Denmark.

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http://dx.doi.org/10.1007/s00125-018-4614-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6445476PMC
July 2018

Translating Mechanism of Regulatory Action of Tolerogenic Dendritic Cells to Monitoring Endpoints in Clinical Trials.

Front Immunol 2017 22;8:1598. Epub 2017 Nov 22.

Department of Immunohematology and Blood Transfusion, Leiden University Medical Center, Leiden, Netherlands.

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http://journal.frontiersin.org/article/10.3389/fimmu.2017.01
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http://dx.doi.org/10.3389/fimmu.2017.01598DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5715363PMC
November 2017

Relapsing/remitting type 1 diabetes.

Diabetologia 2017 11 23;60(11):2252-2255. Epub 2017 Aug 23.

Department of Diabetes Immunology, Diabetes & Metabolism Research Institute, Beckman Research Institute at the City of Hope, 1500 E Duarte Rd, Duarte, CA, 91010, USA.

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http://link.springer.com/10.1007/s00125-017-4403-3
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http://dx.doi.org/10.1007/s00125-017-4403-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6448902PMC
November 2017

The elusive role of B lymphocytes and islet autoantibodies in (human) type 1 diabetes.

Diabetologia 2017 07 24;60(7):1185-1189. Epub 2017 Apr 24.

Department of Immunohaematology and Blood Transfusion, Leiden University Medical Center, Leiden, the Netherlands.

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http://link.springer.com/10.1007/s00125-017-4284-5
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http://dx.doi.org/10.1007/s00125-017-4284-5DOI Listing
July 2017

Immunological Balance Is Associated with Clinical Outcome after Autologous Hematopoietic Stem Cell Transplantation in Type 1 Diabetes.

Front Immunol 2017 22;8:167. Epub 2017 Feb 22.

Center for Cell-based Therapy, Regional Blood Center of Ribeirão Preto, Ribeirão Preto Medical School, University of São Paulo, Ribeirão Preto, Brazil; Department of Internal Medicine, Ribeirão Preto Medical School, University of São Paulo, Ribeirão Preto, Brazil.

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http://dx.doi.org/10.3389/fimmu.2017.00167DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5319960PMC
February 2017

Autoimmunity against a defective ribosomal insulin gene product in type 1 diabetes.

Nat Med 2017 Apr 27;23(4):501-507. Epub 2017 Feb 27.

Departments of Immunohematology &Blood Transfusion, Leiden University Medical Center, Leiden, the Netherlands.

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http://dx.doi.org/10.1038/nm.4289DOI Listing
April 2017

Immunogenicity of human embryonic stem cell-derived beta cells.

Diabetologia 2017 01 27;60(1):126-133. Epub 2016 Oct 27.

Department of Immunohaematology and Blood Transfusion, E3-Q, Leiden University Medical Center, P.O. Box 9600, NL-2300 RC, Leiden, the Netherlands.

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http://link.springer.com/10.1007/s00125-016-4125-y
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http://dx.doi.org/10.1007/s00125-016-4125-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6518073PMC
January 2017

A roadmap of the generation of neoantigens as targets of the immune system in type 1 diabetes.

Curr Opin Immunol 2016 12 7;43:67-73. Epub 2016 Oct 7.

Department of Molecular Cell Biology, Leiden University Medical Center, Leiden, The Netherlands.

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http://dx.doi.org/10.1016/j.coi.2016.09.007DOI Listing
December 2016

Where, How, and When: Positioning Posttranslational Modification Within Type 1 Diabetes Pathogenesis.

Curr Diab Rep 2016 07;16(7):63

Department of Immunohematology and Blood Transfusion, Leiden University Medical Center, E3-Q, PO Box 9600, 2300 RC, Leiden, The Netherlands.

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http://dx.doi.org/10.1007/s11892-016-0752-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4863913PMC
July 2016

Neoantigens and Microenvironment in Type 1 Diabetes: Lessons from Antitumor Immunity.

Trends Endocrinol Metab 2016 06 16;27(6):353-362. Epub 2016 Apr 16.

Department of Immunohematology and Blood Transfusion, Leiden University Medical Center, Leiden, The Netherlands; Department of Diabetes Immunology, Diabetes and Metabolism Research Institute at the Beckman Research Institute of the City of Hope, Duarte, CA 91010, USA. Electronic address:

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http://dx.doi.org/10.1016/j.tem.2016.03.013DOI Listing
June 2016

Dendritic Cells Guide Islet Autoimmunity through a Restricted and Uniquely Processed Peptidome Presented by High-Risk HLA-DR.

J Immunol 2016 Apr 4;196(8):3253-63. Epub 2016 Mar 4.

Department of Immunohematology and Blood Transfusion, Leiden University Medical Center, 2300 RC Leiden, the Netherlands; Department of Diabetes Immunology, Diabetes and Metabolism Research Institute, Beckman Research Institute of City of Hope, Duarte, CA 91010

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http://www.jimmunol.org/lookup/doi/10.4049/jimmunol.1501282
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http://dx.doi.org/10.4049/jimmunol.1501282DOI Listing
April 2016

Insulitis Revisited.

Authors:
Bart O Roep

Diabetes 2016 Mar;65(3):545-7

Department of Immunohematology and Blood Transfusion, Leiden University Medical Center, Leiden, the Netherlands, and Department of Diabetes Immunology, Diabetes & Metabolism Research Institute, Beckman Research Institute of City of Hope, Duarte, CA

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http://dx.doi.org/10.2337/dbi15-0040DOI Listing
March 2016

Discovery of a Selective Islet Peptidome Presented by the Highest-Risk HLA-DQ8trans Molecule.

Diabetes 2016 Mar 30;65(3):732-41. Epub 2015 Dec 30.

Department of Immunohematology and Blood Transfusion, Leiden University Medical Center, Leiden, the Netherlands Department of Diabetes Immunology, Diabetes & Metabolism Research Institute at the Beckman Research Institute of City of Hope, Duarte, CA

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http://dx.doi.org/10.2337/db15-1031DOI Listing
March 2016

Innate and adaptive immunity to human beta cell lines: implications for beta cell therapy.

Diabetologia 2016 Jan;59(1):170-175

Department of Immunohematology and Blood Transfusion, Leiden University Medical Center, E3-Q, P.O. Box 9600, 2300 RC, Leiden, the Netherlands.

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http://dx.doi.org/10.1007/s00125-015-3779-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4670455PMC
January 2016

Inducing tissue specific tolerance in autoimmune disease with tolerogenic dendritic cells.

Clin Exp Rheumatol 2015 Jul-Aug;33(4 Suppl 92):S97-103. Epub 2015 Oct 12.

Department of Immunohematology and Blood Transfusion, Leiden University Medical Center, Leiden, The Netherlands.

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December 2015

T cell receptor reversed polarity recognition of a self-antigen major histocompatibility complex.

Nat Immunol 2015 Nov 5;16(11):1153-61. Epub 2015 Oct 5.

Infection and Immunity Program and The Department of Biochemistry and Molecular Biology, Biomedicine Discovery Institute, Monash University, Clayton, Victoria, Australia.

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http://dx.doi.org/10.1038/ni.3271DOI Listing
November 2015

Vitamin D receptor polymorphisms and growth until adulthood after very premature birth.

J Bone Miner Metab 2016 Sep 28;34(5):564-70. Epub 2015 Jul 28.

Department of Pediatrics, Leiden University Medical Center, P.O. Box 9600, 2300 RC, Leiden, The Netherlands.

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http://dx.doi.org/10.1007/s00774-015-0697-8DOI Listing
September 2016

Primary prevention for type 1 diabetes mellitus?

Authors:
Bart O Roep

Nat Rev Endocrinol 2015 Aug 16;11(8):451-2. Epub 2015 Jun 16.

Department of Immunohaematology and Blood Transfusion, Leiden University Medical Center, P.O. Box 9600, NL-2300RC Leiden, Netherlands.

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http://dx.doi.org/10.1038/nrendo.2015.95DOI Listing
August 2015

Impact of disease heterogeneity on treatment efficacy of immunotherapy in Type 1 diabetes: different shades of gray.

Immunotherapy 2015 ;7(2):163-74

Department of Immunohematology & Blood Transfusion, Leiden University Medical Center, E3-Q, LUMC, PO Box 9600, NL-2300RC Leiden, The Netherlands.

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http://dx.doi.org/10.2217/imt.14.104DOI Listing
November 2015

Immune intervention therapy in type 1 diabetes: safety first.

Authors:
Bart O Roep

Lancet Diabetes Endocrinol 2013 Dec 8;1(4):263-5. Epub 2013 Oct 8.

Department of Immunohaematology and Blood Transfusion, Leiden University Medical Center, Leiden NL-2333ZA 2, Netherlands. Electronic address:

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http://dx.doi.org/10.1016/S2213-8587(13)70124-4DOI Listing
December 2013

Immune modulation in humans: implications for type 1 diabetes mellitus.

Nat Rev Endocrinol 2014 Apr 28;10(4):229-42. Epub 2014 Jan 28.

Department of Immunobiology, King's College London, School of Medicine, London SE1 9RT, UK.

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http://www.nature.com/articles/nrendo.2014.2
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http://dx.doi.org/10.1038/nrendo.2014.2DOI Listing
April 2014

Targeting proinsulin-reactive CD8+ T cells: a new direction for type 1 diabetes treatment.

Expert Rev Clin Immunol 2013 Nov;9(11):1001-3

Department of Immunohematology & Blood Transfusion, Leiden University Medical Center, Leiden, The Netherlands.

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http://www.tandfonline.com/doi/full/10.1586/1744666X.2013.85
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http://dx.doi.org/10.1586/1744666X.2013.852958DOI Listing
November 2013

Infectious tolerance as candidate therapy for type 1 diabetes: transfer of immunoregulatory properties from human regulatory T cells to other T cells and proinflammatory dendritic cells.

Crit Rev Immunol 2013 ;33(5):415-34

Department of Immunohematology & Blood Transfusion, Leiden University Medical Center, Leiden, The Netherlands.

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http://dx.doi.org/10.1615/critrevimmunol.2013006782DOI Listing
January 2014

Posttranslational modification of HLA-DQ binding islet autoantigens in type 1 diabetes.

Diabetes 2014 Jan 2;63(1):237-47. Epub 2013 Oct 2.

Department of Immunohematology and Blood Transfusion, Leiden University Medical Center, Leiden, the Netherlands.

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http://diabetes.diabetesjournals.org/cgi/doi/10.2337/db12-12
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http://dx.doi.org/10.2337/db12-1214DOI Listing
January 2014

Pretransplantation GAD-autoantibody status to guide prophylactic antibody induction therapy in simultaneous pancreas and kidney transplantation.

Transplantation 2013 Oct;96(8):745-52

1 Department of Surgery, Leiden University Medical Center, Leiden, The Netherlands. 2 Department of Immunohematology & Blood Transfusion, Leiden University Medical Center, Leiden, The Netherlands. 3 Department of Nephrology, Leiden University Medical Center, Leiden, The Netherlands. 4 Department of Immunology of Diabetes Unit, San Raffaele Scientific Institute Milan, Italy. 5 Center for Regenerative Therapies Dresden, Dresden, Germany. 6 Address correspondence to: Johan W. de Fijter, M.D., Ph.D., Department of Nephrology, Leiden University Medical Center, C3-P22, P.O. Box 9600, NL-2300 RC Leiden, The Netherlands.

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http://dx.doi.org/10.1097/TP.0b013e3182a012ccDOI Listing
October 2013

Changing faces, unmasking the beta-cell: post-translational modification of antigens in type 1 diabetes.

Curr Opin Endocrinol Diabetes Obes 2013 Aug;20(4):299-306

Department of Immunohematology and Blood Transfusion, Leiden University Medical Center, Leiden, The Netherlands.

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http://dx.doi.org/10.1097/MED.0b013e3283631417DOI Listing
August 2013

Regulatory multitasking of tolerogenic dendritic cells - lessons taken from vitamin d3-treated tolerogenic dendritic cells.

Front Immunol 2013 14;4:113. Epub 2013 May 14.

Department of Immunohematology and Blood Transfusion, Leiden University Medical Center Leiden, Netherlands.

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http://dx.doi.org/10.3389/fimmu.2013.00113DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3653108PMC
May 2013

β-Cells, autoimmunity, and the innate immune system: "un ménage á trois"?

Authors:
Bart O Roep

Diabetes 2013 Jun;62(6):1821-2

Department of Immunohaematology and Blood Transfusion, Leiden University Medical Center, Leiden, The Netherlands.

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http://diabetes.diabetesjournals.org/cgi/doi/10.2337/db13-02
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http://dx.doi.org/10.2337/db13-0276DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3661633PMC
June 2013

Biomarkers for immune intervention trials in type 1 diabetes.

Clin Immunol 2013 Dec 27;149(3):286-96. Epub 2013 Feb 27.

Cochin Institute, INSERM U1016, DeAR Lab Avenir, Paris, France; Paris Descartes University, Sorbonne Paris Cité, Faculté de Médecine, Paris, France; Assistance Publique Hôpitaux de Paris, Hôtel Dieu, Service de Diabétologie, Paris, France. Electronic address:

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http://dx.doi.org/10.1016/j.clim.2013.02.009DOI Listing
December 2013

Notch controls generation and function of human effector CD8+ T cells.

Blood 2013 Apr 4;121(14):2638-46. Epub 2013 Feb 4.

Department of Molecular Cell Biology and Immunology, VU University Medical Center Amsterdam, Amsterdam, The Netherlands.

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http://dx.doi.org/10.1182/blood-2012-07-442962DOI Listing
April 2013

Local autoantigen expression as essential gatekeeper of memory T-cell recruitment to islet grafts in diabetic hosts.

Diabetes 2013 Mar 16;62(3):905-11. Epub 2012 Nov 16.

Julia McFarlane Diabetes Research Centre and Department of Microbiology, Immunology, and Infectious Diseases, Faculty of Medicine, University of Calgary, Calgary, Alberta, Canada.

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http://diabetes.diabetesjournals.org/content/early/2012/11/1
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http://diabetes.diabetesjournals.org/cgi/doi/10.2337/db12-06
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http://dx.doi.org/10.2337/db12-0600DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3581210PMC
March 2013

Tolerogenic dendritic cells impede priming of naïve CD8⁺ T cells and deplete memory CD8⁺ T cells.

Eur J Immunol 2013 Jan 12;43(1):85-92. Epub 2012 Nov 12.

Department of Immunohematology and Blood Transfusion, Leiden University Medical Center, Leiden, The Netherlands.

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http://dx.doi.org/10.1002/eji.201242879DOI Listing
January 2013

[Immunotherapy for type 1 diabetes mellitus (DM1)].

Ned Tijdschr Geneeskd 2012 ;156(15):A4268

Leids Universitair Medisch Centrum, afd. Immunohaematologie & Bloedtransfusie, Leiden, the Netherlands.

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May 2012

Antigen targets of type 1 diabetes autoimmunity.

Cold Spring Harb Perspect Med 2012 Apr;2(4):a007781

Department of Immunohematology and Blood Transfusion, Leiden University Medical Center, 2333 Leiden, The Netherlands.

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http://dx.doi.org/10.1101/cshperspect.a007781DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3312399PMC
April 2012

The problems and promises of research into human immunology and autoimmune disease.

Nat Med 2012 Jan 6;18(1):48-53. Epub 2012 Jan 6.

Leiden University Medical Center, National Diabetes Expert Center, Department of Immunohaematology and Blood Transfusion, Leiden, The Netherlands.

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http://dx.doi.org/10.1038/nm.2626DOI Listing
January 2012

Differential protein pathways in 1,25-dihydroxyvitamin d(3) and dexamethasone modulated tolerogenic human dendritic cells.

J Proteome Res 2012 Feb 15;11(2):941-71. Epub 2011 Dec 15.

Laboratory for Experimental Medicine and Endocrinology (LEGENDO), University Hospital Gasthuisberg, Catholic University of Leuven, Herestraat 49, box 902, B-3000 Leuven, Belgium.

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http://pubs.acs.org/doi/10.1021/pr200724e
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http://dx.doi.org/10.1021/pr200724eDOI Listing
February 2012

Transfer of regulatory properties from tolerogenic to proinflammatory dendritic cells via induced autoreactive regulatory T cells.

J Immunol 2011 Dec 14;187(12):6357-64. Epub 2011 Nov 14.

Department of Immunohematology and Blood Transfusion, Leiden University Medical Center, 2333 ZA Leiden, The Netherlands.

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http://dx.doi.org/10.4049/jimmunol.1101638DOI Listing
December 2011

Preservation of recall immunity in anti-CD3-treated recent onset type 1 diabetes patients.

Diabetes Metab Res Rev 2011 Nov;27(8):925-7

Juvenile Diabetes Research Foundation Center for β-Cell Therapy in Diabetes, Leiden, The Netherlands.

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http://dx.doi.org/10.1002/dmrr.1273DOI Listing
November 2011

Diabetogenic T lymphocytes in human Type 1 diabetes.

Curr Opin Immunol 2011 Dec 1;23(6):746-53. Epub 2011 Nov 1.

Department of Immunohematology and Blood Transfusion, Leiden University Medical Centre, Leiden, The Netherlands.

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http://dx.doi.org/10.1016/j.coi.2011.10.001DOI Listing
December 2011

Structure-based selection of small molecules to alter allele-specific MHC class II antigen presentation.

J Immunol 2011 Dec 31;187(11):5921-30. Epub 2011 Oct 31.

Barbara Davis Center for Childhood Diabetes, University of Colorado Denver, Aurora, CO 80045, USA.

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http://dx.doi.org/10.4049/jimmunol.1100746DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3221928PMC
December 2011

Gluten-specific T cells cross-react between HLA-DQ8 and the HLA-DQ2α/DQ8β transdimer.

J Immunol 2011 Nov 17;187(10):5123-9. Epub 2011 Oct 17.

Department of Immunohematology and Blood Transfusion, Leiden University Medical Center, 2333 ZA Leiden, The Netherlands.

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http://www.jimmunol.org/lookup/doi/10.4049/jimmunol.1101179
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http://dx.doi.org/10.4049/jimmunol.1101179DOI Listing
November 2011

New hope for immune intervention therapy in type 1 diabetes.

Authors:
Bart O Roep

Lancet 2011 Jul 28;378(9789):376-8. Epub 2011 Jun 28.

Department of Immunohaematology and Blood Transfusion, Leiden University Medical Center, Leiden NL-2300RC, Netherlands.

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http://dx.doi.org/10.1016/S0140-6736(11)60977-XDOI Listing
July 2011

IGF1 promoter polymorphism and cranial growth in individuals born very preterm.

Horm Res Paediatr 2011 31;76(1):27-34. Epub 2011 Mar 31.

Department of Clinical Epidemiology, Leiden University Medical Center, The Netherlands.

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https://www.karger.com/Article/FullText/324460
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http://dx.doi.org/10.1159/000324460DOI Listing
November 2011

Beta cells under attack: toward a better understanding of type 1 diabetes immunopathology.

Semin Immunopathol 2011 Jan 18;33(1):1-7. Epub 2010 Dec 18.

La Jolla Institute for Allergy and Immunology, 9420 Athena Circle, La Jolla, CA 92037, USA.

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http://dx.doi.org/10.1007/s00281-010-0236-6DOI Listing
January 2011

Critical role for TNF in the induction of human antigen-specific regulatory T cells by tolerogenic dendritic cells.

J Immunol 2010 Aug 23;185(3):1412-8. Epub 2010 Jun 23.

Department of Immunohematology and Blood Transfusion, Leiden University Medical Center, P.O. Box 9600, 2300 RC Leiden, The Netherlands.

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http://dx.doi.org/10.4049/jimmunol.1000560DOI Listing
August 2010

Association analysis of myosin IXB and type 1 diabetes.

Hum Immunol 2010 Jun 1;71(6):598-601. Epub 2010 Apr 1.

Department Immunohematology and Blood Transfusion, Leiden University Medical Center, Leiden, The Netherlands.

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http://dx.doi.org/10.1016/j.humimm.2010.03.002DOI Listing
June 2010

Surrogate end points in the design of immunotherapy trials: emerging lessons from type 1 diabetes.

Nat Rev Immunol 2010 02;10(2):145-52

Leiden University Medical Center, National Diabetes Expert Center, Leiden, The Netherlands.

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http://dx.doi.org/10.1038/nri2705DOI Listing
February 2010

Current advances and travails in islet transplantation.

Diabetes 2009 Oct;58(10):2175-84

National Institute of Diabetes and Digestive and Kidney Diseases/National Institutes of Health, Diabetes Branch, Bethesda, Maryland, USA.

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http://dx.doi.org/10.2337/db09-0476DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2750210PMC
October 2009

Challenges in developing endpoints for type 1 diabetes intervention studies.

Diabetes Metab Res Rev 2009 Nov;25(8):694-704

Department of Endocrinology and Diabetes, University Campus Bio-Medico, Rome, Italy.

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http://dx.doi.org/10.1002/dmrr.1002DOI Listing
November 2009