Bart O Roep

Bart O Roep

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Bart O Roep

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A Future for Autologous Hematopoietic Stem Cell Transplantation in Type 1 Diabetes.

Front Immunol 2018 6;9:690. Epub 2018 Apr 6.

Department of Diabetes Immunology, Diabetes & Metabolism Research Institute, Beckman Research Institute at the City of Hope, Duarte, CA, United States.

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http://dx.doi.org/10.3389/fimmu.2018.00690DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5904498PMC
June 2019

Epitope Stealing as a Mechanism of Dominant Protection by HLA-DQ6 in Type 1 Diabetes.

Diabetes 2019 04 9;68(4):787-795. Epub 2019 Jan 9.

Department of Immunohematology and Blood Transfusion, Leiden University Medical Center, Leiden, the Netherlands

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http://diabetes.diabetesjournals.org/lookup/doi/10.2337/db18
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http://dx.doi.org/10.2337/db18-0501DOI Listing
April 2019

Activated Mesenchymal Stromal Cells Process and Present Antigens Regulating Adaptive Immunity.

Front Immunol 2019 3;10:694. Epub 2019 Apr 3.

Department of Diabetes Immunology, Diabetes and Metabolism Research Institute at the Beckman Research Institute of City of Hope, Duarte, CA, United States.

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https://www.frontiersin.org/article/10.3389/fimmu.2019.00694
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http://dx.doi.org/10.3389/fimmu.2019.00694DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6457321PMC
April 2019

Diabetes relief in mice by glucose-sensing insulin-secreting human α-cells.

Nature 2019 03 13;567(7746):43-48. Epub 2019 Feb 13.

Department of Genetic Medicine and Development, iGE3 and Centre Facultaire du Diabète, Faculty of Medicine, University of Geneva, Geneva, Switzerland.

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http://dx.doi.org/10.1038/s41586-019-0942-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6624841PMC
March 2019

The challenge of modulating β-cell autoimmunity in type 1 diabetes.

Lancet Diabetes Endocrinol 2019 Jan 24;7(1):52-64. Epub 2018 Oct 24.

Peter Gorer Department of Immunobiology, Faculty of Life Sciences & Medicine, King's College London, London, UK; King's Health Partners Institute of Diabetes, Obesity and Endocrinology, London, UK.

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https://linkinghub.elsevier.com/retrieve/pii/S22138587183011
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http://dx.doi.org/10.1016/S2213-8587(18)30112-8DOI Listing
January 2019

Antigen-based immune modulation therapy for type 1 diabetes: the era of precision medicine.

Lancet Diabetes Endocrinol 2019 Jan 24;7(1):65-74. Epub 2018 Oct 24.

Peter Gorer Department of Immunobiology, Faculty of Life Sciences & Medicine, King's College London, London, UK; King's Health Partners Institute of Diabetes, Obesity and Endocrinology, London, UK. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S22138587183010
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http://dx.doi.org/10.1016/S2213-8587(18)30109-8DOI Listing
January 2019

Syntaxin 4 Expression in Pancreatic β-Cells Promotes Islet Function and Protects Functional β-Cell Mass.

Diabetes 2018 12 10;67(12):2626-2639. Epub 2018 Oct 10.

Department of Molecular and Cellular Endocrinology, Diabetes and Metabolism Research Institute of City of Hope, Duarte, CA

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http://diabetes.diabetesjournals.org/lookup/doi/10.2337/db18
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http://dx.doi.org/10.2337/db18-0259DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6245223PMC
December 2018

Bioluminescent reporter assay for monitoring ER stress in human beta cells.

Sci Rep 2018 Dec 10;8(1):17738. Epub 2018 Dec 10.

Departments of Cell and Chemical Biology, Leiden University Medical Center, Leiden, The Netherlands.

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http://www.nature.com/articles/s41598-018-36142-4
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http://dx.doi.org/10.1038/s41598-018-36142-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6288136PMC
December 2018

Islet stress, degradation and autoimmunity.

Diabetes Obes Metab 2018 09;20 Suppl 2:88-94

Department of Immunohematology and Blood bank Leiden University Medical Center, Leiden University Medical Center, Leiden, The Netherlands.

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http://doi.wiley.com/10.1111/dom.13387
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http://dx.doi.org/10.1111/dom.13387DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6174957PMC
September 2018

Abnormal islet sphingolipid metabolism in type 1 diabetes.

Diabetologia 2018 07 18;61(7):1650-1661. Epub 2018 Apr 18.

The Bartholin Institute, Department of Pathology, Rigshospitalet, Copenhagen Biocenter, Ole Maaløes Vej 5, 2200, Copenhagen N, Denmark.

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http://dx.doi.org/10.1007/s00125-018-4614-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6445476PMC
July 2018

Erratum to: Understanding and preventing type 1 diabetes through the unique working model of TrialNet.

Diabetologia 2017 12;60(12):2540

Department of Immunobiology, Faculty of Life Sciences & Medicine, King's College London, London, SE1 9RT, UK.

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http://dx.doi.org/10.1007/s00125-017-4446-5DOI Listing
December 2017

Relapsing/remitting type 1 diabetes.

Diabetologia 2017 11 23;60(11):2252-2255. Epub 2017 Aug 23.

Department of Diabetes Immunology, Diabetes & Metabolism Research Institute, Beckman Research Institute at the City of Hope, 1500 E Duarte Rd, Duarte, CA, 91010, USA.

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http://link.springer.com/10.1007/s00125-017-4403-3
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http://dx.doi.org/10.1007/s00125-017-4403-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6448902PMC
November 2017

Translating Mechanism of Regulatory Action of Tolerogenic Dendritic Cells to Monitoring Endpoints in Clinical Trials.

Front Immunol 2017 22;8:1598. Epub 2017 Nov 22.

Department of Immunohematology and Blood Transfusion, Leiden University Medical Center, Leiden, Netherlands.

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http://journal.frontiersin.org/article/10.3389/fimmu.2017.01
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http://dx.doi.org/10.3389/fimmu.2017.01598DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5715363PMC
November 2017

The elusive role of B lymphocytes and islet autoantibodies in (human) type 1 diabetes.

Diabetologia 2017 07 24;60(7):1185-1189. Epub 2017 Apr 24.

Department of Immunohaematology and Blood Transfusion, Leiden University Medical Center, Leiden, the Netherlands.

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http://link.springer.com/10.1007/s00125-017-4284-5
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http://dx.doi.org/10.1007/s00125-017-4284-5DOI Listing
July 2017

Autoimmunity against a defective ribosomal insulin gene product in type 1 diabetes.

Nat Med 2017 Apr 27;23(4):501-507. Epub 2017 Feb 27.

Departments of Immunohematology &Blood Transfusion, Leiden University Medical Center, Leiden, the Netherlands.

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http://dx.doi.org/10.1038/nm.4289DOI Listing
April 2017

Immunological Balance Is Associated with Clinical Outcome after Autologous Hematopoietic Stem Cell Transplantation in Type 1 Diabetes.

Front Immunol 2017 22;8:167. Epub 2017 Feb 22.

Center for Cell-based Therapy, Regional Blood Center of Ribeirão Preto, Ribeirão Preto Medical School, University of São Paulo, Ribeirão Preto, Brazil; Department of Internal Medicine, Ribeirão Preto Medical School, University of São Paulo, Ribeirão Preto, Brazil.

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http://dx.doi.org/10.3389/fimmu.2017.00167DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5319960PMC
February 2017

Immunogenicity of human embryonic stem cell-derived beta cells.

Diabetologia 2017 01 27;60(1):126-133. Epub 2016 Oct 27.

Department of Immunohaematology and Blood Transfusion, E3-Q, Leiden University Medical Center, P.O. Box 9600, NL-2300 RC, Leiden, the Netherlands.

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http://link.springer.com/10.1007/s00125-016-4125-y
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http://dx.doi.org/10.1007/s00125-016-4125-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6518073PMC
January 2017

A roadmap of the generation of neoantigens as targets of the immune system in type 1 diabetes.

Curr Opin Immunol 2016 12 7;43:67-73. Epub 2016 Oct 7.

Department of Molecular Cell Biology, Leiden University Medical Center, Leiden, The Netherlands.

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http://dx.doi.org/10.1016/j.coi.2016.09.007DOI Listing
December 2016

Vitamin D receptor polymorphisms and growth until adulthood after very premature birth.

J Bone Miner Metab 2016 Sep 28;34(5):564-70. Epub 2015 Jul 28.

Department of Pediatrics, Leiden University Medical Center, P.O. Box 9600, 2300 RC, Leiden, The Netherlands.

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http://dx.doi.org/10.1007/s00774-015-0697-8DOI Listing
September 2016

Where, How, and When: Positioning Posttranslational Modification Within Type 1 Diabetes Pathogenesis.

Curr Diab Rep 2016 07;16(7):63

Department of Immunohematology and Blood Transfusion, Leiden University Medical Center, E3-Q, PO Box 9600, 2300 RC, Leiden, The Netherlands.

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http://dx.doi.org/10.1007/s11892-016-0752-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4863913PMC
July 2016

Neoantigens and Microenvironment in Type 1 Diabetes: Lessons from Antitumor Immunity.

Trends Endocrinol Metab 2016 06 16;27(6):353-362. Epub 2016 Apr 16.

Department of Immunohematology and Blood Transfusion, Leiden University Medical Center, Leiden, The Netherlands; Department of Diabetes Immunology, Diabetes and Metabolism Research Institute at the Beckman Research Institute of the City of Hope, Duarte, CA 91010, USA. Electronic address:

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http://dx.doi.org/10.1016/j.tem.2016.03.013DOI Listing
June 2016

Dendritic Cells Guide Islet Autoimmunity through a Restricted and Uniquely Processed Peptidome Presented by High-Risk HLA-DR.

J Immunol 2016 Apr 4;196(8):3253-63. Epub 2016 Mar 4.

Department of Immunohematology and Blood Transfusion, Leiden University Medical Center, 2300 RC Leiden, the Netherlands; Department of Diabetes Immunology, Diabetes and Metabolism Research Institute, Beckman Research Institute of City of Hope, Duarte, CA 91010

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http://www.jimmunol.org/lookup/doi/10.4049/jimmunol.1501282
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http://dx.doi.org/10.4049/jimmunol.1501282DOI Listing
April 2016

Discovery of a Selective Islet Peptidome Presented by the Highest-Risk HLA-DQ8trans Molecule.

Diabetes 2016 Mar 30;65(3):732-41. Epub 2015 Dec 30.

Department of Immunohematology and Blood Transfusion, Leiden University Medical Center, Leiden, the Netherlands Department of Diabetes Immunology, Diabetes & Metabolism Research Institute at the Beckman Research Institute of City of Hope, Duarte, CA

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http://dx.doi.org/10.2337/db15-1031DOI Listing
March 2016

Insulitis Revisited.

Authors:
Bart O Roep

Diabetes 2016 Mar;65(3):545-7

Department of Immunohematology and Blood Transfusion, Leiden University Medical Center, Leiden, the Netherlands, and Department of Diabetes Immunology, Diabetes & Metabolism Research Institute, Beckman Research Institute of City of Hope, Duarte, CA

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http://dx.doi.org/10.2337/dbi15-0040DOI Listing
March 2016

Innate and adaptive immunity to human beta cell lines: implications for beta cell therapy.

Diabetologia 2016 Jan;59(1):170-175

Department of Immunohematology and Blood Transfusion, Leiden University Medical Center, E3-Q, P.O. Box 9600, 2300 RC, Leiden, the Netherlands.

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http://dx.doi.org/10.1007/s00125-015-3779-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4670455PMC
January 2016

Inducing tissue specific tolerance in autoimmune disease with tolerogenic dendritic cells.

Clin Exp Rheumatol 2015 Jul-Aug;33(4 Suppl 92):S97-103. Epub 2015 Oct 12.

Department of Immunohematology and Blood Transfusion, Leiden University Medical Center, Leiden, The Netherlands.

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December 2015

Impact of disease heterogeneity on treatment efficacy of immunotherapy in Type 1 diabetes: different shades of gray.

Immunotherapy 2015 ;7(2):163-74

Department of Immunohematology & Blood Transfusion, Leiden University Medical Center, E3-Q, LUMC, PO Box 9600, NL-2300RC Leiden, The Netherlands.

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http://dx.doi.org/10.2217/imt.14.104DOI Listing
November 2015

T cell receptor reversed polarity recognition of a self-antigen major histocompatibility complex.

Nat Immunol 2015 Nov 5;16(11):1153-61. Epub 2015 Oct 5.

Infection and Immunity Program and The Department of Biochemistry and Molecular Biology, Biomedicine Discovery Institute, Monash University, Clayton, Victoria, Australia.

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http://dx.doi.org/10.1038/ni.3271DOI Listing
November 2015

Primary prevention for type 1 diabetes mellitus?

Authors:
Bart O Roep

Nat Rev Endocrinol 2015 Aug 16;11(8):451-2. Epub 2015 Jun 16.

Department of Immunohaematology and Blood Transfusion, Leiden University Medical Center, P.O. Box 9600, NL-2300RC Leiden, Netherlands.

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http://dx.doi.org/10.1038/nrendo.2015.95DOI Listing
August 2015

Immune modulation in humans: implications for type 1 diabetes mellitus.

Nat Rev Endocrinol 2014 Apr 28;10(4):229-42. Epub 2014 Jan 28.

Department of Immunobiology, King's College London, School of Medicine, London SE1 9RT, UK.

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http://www.nature.com/articles/nrendo.2014.2
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http://dx.doi.org/10.1038/nrendo.2014.2DOI Listing
April 2014

Posttranslational modification of HLA-DQ binding islet autoantigens in type 1 diabetes.

Diabetes 2014 Jan 2;63(1):237-47. Epub 2013 Oct 2.

Department of Immunohematology and Blood Transfusion, Leiden University Medical Center, Leiden, the Netherlands.

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http://diabetes.diabetesjournals.org/cgi/doi/10.2337/db12-12
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http://dx.doi.org/10.2337/db12-1214DOI Listing
January 2014

Infectious tolerance as candidate therapy for type 1 diabetes: transfer of immunoregulatory properties from human regulatory T cells to other T cells and proinflammatory dendritic cells.

Crit Rev Immunol 2013 ;33(5):415-34

Department of Immunohematology & Blood Transfusion, Leiden University Medical Center, Leiden, The Netherlands.

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January 2014

Biomarkers for immune intervention trials in type 1 diabetes.

Clin Immunol 2013 Dec 27;149(3):286-96. Epub 2013 Feb 27.

Cochin Institute, INSERM U1016, DeAR Lab Avenir, Paris, France; Paris Descartes University, Sorbonne Paris Cité, Faculté de Médecine, Paris, France; Assistance Publique Hôpitaux de Paris, Hôtel Dieu, Service de Diabétologie, Paris, France. Electronic address:

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http://dx.doi.org/10.1016/j.clim.2013.02.009DOI Listing
December 2013

Immune intervention therapy in type 1 diabetes: safety first.

Authors:
Bart O Roep

Lancet Diabetes Endocrinol 2013 Dec 8;1(4):263-5. Epub 2013 Oct 8.

Department of Immunohaematology and Blood Transfusion, Leiden University Medical Center, Leiden NL-2333ZA 2, Netherlands. Electronic address:

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http://dx.doi.org/10.1016/S2213-8587(13)70124-4DOI Listing
December 2013

Targeting proinsulin-reactive CD8+ T cells: a new direction for type 1 diabetes treatment.

Expert Rev Clin Immunol 2013 Nov;9(11):1001-3

Department of Immunohematology & Blood Transfusion, Leiden University Medical Center, Leiden, The Netherlands.

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http://www.tandfonline.com/doi/full/10.1586/1744666X.2013.85
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http://dx.doi.org/10.1586/1744666X.2013.852958DOI Listing
November 2013

Pretransplantation GAD-autoantibody status to guide prophylactic antibody induction therapy in simultaneous pancreas and kidney transplantation.

Transplantation 2013 Oct;96(8):745-52

1 Department of Surgery, Leiden University Medical Center, Leiden, The Netherlands. 2 Department of Immunohematology & Blood Transfusion, Leiden University Medical Center, Leiden, The Netherlands. 3 Department of Nephrology, Leiden University Medical Center, Leiden, The Netherlands. 4 Department of Immunology of Diabetes Unit, San Raffaele Scientific Institute Milan, Italy. 5 Center for Regenerative Therapies Dresden, Dresden, Germany. 6 Address correspondence to: Johan W. de Fijter, M.D., Ph.D., Department of Nephrology, Leiden University Medical Center, C3-P22, P.O. Box 9600, NL-2300 RC Leiden, The Netherlands.

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http://dx.doi.org/10.1097/TP.0b013e3182a012ccDOI Listing
October 2013

Changing faces, unmasking the beta-cell: post-translational modification of antigens in type 1 diabetes.

Curr Opin Endocrinol Diabetes Obes 2013 Aug;20(4):299-306

Department of Immunohematology and Blood Transfusion, Leiden University Medical Center, Leiden, The Netherlands.

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http://dx.doi.org/10.1097/MED.0b013e3283631417DOI Listing
August 2013

β-Cells, autoimmunity, and the innate immune system: "un ménage á trois"?

Authors:
Bart O Roep

Diabetes 2013 Jun;62(6):1821-2

Department of Immunohaematology and Blood Transfusion, Leiden University Medical Center, Leiden, The Netherlands.

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http://diabetes.diabetesjournals.org/cgi/doi/10.2337/db13-02
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http://dx.doi.org/10.2337/db13-0276DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3661633PMC
June 2013

Regulatory multitasking of tolerogenic dendritic cells - lessons taken from vitamin d3-treated tolerogenic dendritic cells.

Front Immunol 2013 14;4:113. Epub 2013 May 14.

Department of Immunohematology and Blood Transfusion, Leiden University Medical Center Leiden, Netherlands.

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http://dx.doi.org/10.3389/fimmu.2013.00113DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3653108PMC
May 2013

Notch controls generation and function of human effector CD8+ T cells.

Blood 2013 Apr 4;121(14):2638-46. Epub 2013 Feb 4.

Department of Molecular Cell Biology and Immunology, VU University Medical Center Amsterdam, Amsterdam, The Netherlands.

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http://dx.doi.org/10.1182/blood-2012-07-442962DOI Listing
April 2013

Local autoantigen expression as essential gatekeeper of memory T-cell recruitment to islet grafts in diabetic hosts.

Diabetes 2013 Mar 16;62(3):905-11. Epub 2012 Nov 16.

Julia McFarlane Diabetes Research Centre and Department of Microbiology, Immunology, and Infectious Diseases, Faculty of Medicine, University of Calgary, Calgary, Alberta, Canada.

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http://diabetes.diabetesjournals.org/content/early/2012/11/1
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http://diabetes.diabetesjournals.org/cgi/doi/10.2337/db12-06
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http://dx.doi.org/10.2337/db12-0600DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3581210PMC
March 2013

Tolerogenic dendritic cells impede priming of naïve CD8⁺ T cells and deplete memory CD8⁺ T cells.

Eur J Immunol 2013 Jan 12;43(1):85-92. Epub 2012 Nov 12.

Department of Immunohematology and Blood Transfusion, Leiden University Medical Center, Leiden, The Netherlands.

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http://dx.doi.org/10.1002/eji.201242879DOI Listing
January 2013

[Immunotherapy for type 1 diabetes mellitus (DM1)].

Ned Tijdschr Geneeskd 2012 ;156(15):A4268

Leids Universitair Medisch Centrum, afd. Immunohaematologie & Bloedtransfusie, Leiden, the Netherlands.

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May 2012

Antigen targets of type 1 diabetes autoimmunity.

Cold Spring Harb Perspect Med 2012 Apr;2(4):a007781

Department of Immunohematology and Blood Transfusion, Leiden University Medical Center, 2333 Leiden, The Netherlands.

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http://dx.doi.org/10.1101/cshperspect.a007781DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3312399PMC
April 2012

Differential protein pathways in 1,25-dihydroxyvitamin d(3) and dexamethasone modulated tolerogenic human dendritic cells.

J Proteome Res 2012 Feb 15;11(2):941-71. Epub 2011 Dec 15.

Laboratory for Experimental Medicine and Endocrinology (LEGENDO), University Hospital Gasthuisberg, Catholic University of Leuven, Herestraat 49, box 902, B-3000 Leuven, Belgium.

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http://pubs.acs.org/doi/10.1021/pr200724e
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http://dx.doi.org/10.1021/pr200724eDOI Listing
February 2012

The problems and promises of research into human immunology and autoimmune disease.

Nat Med 2012 Jan 6;18(1):48-53. Epub 2012 Jan 6.

Leiden University Medical Center, National Diabetes Expert Center, Department of Immunohaematology and Blood Transfusion, Leiden, The Netherlands.

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http://dx.doi.org/10.1038/nm.2626DOI Listing
January 2012

Structure-based selection of small molecules to alter allele-specific MHC class II antigen presentation.

J Immunol 2011 Dec 31;187(11):5921-30. Epub 2011 Oct 31.

Barbara Davis Center for Childhood Diabetes, University of Colorado Denver, Aurora, CO 80045, USA.

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http://dx.doi.org/10.4049/jimmunol.1100746DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3221928PMC
December 2011

Diabetogenic T lymphocytes in human Type 1 diabetes.

Curr Opin Immunol 2011 Dec 1;23(6):746-53. Epub 2011 Nov 1.

Department of Immunohematology and Blood Transfusion, Leiden University Medical Centre, Leiden, The Netherlands.

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http://dx.doi.org/10.1016/j.coi.2011.10.001DOI Listing
December 2011

Transfer of regulatory properties from tolerogenic to proinflammatory dendritic cells via induced autoreactive regulatory T cells.

J Immunol 2011 Dec 14;187(12):6357-64. Epub 2011 Nov 14.

Department of Immunohematology and Blood Transfusion, Leiden University Medical Center, 2333 ZA Leiden, The Netherlands.

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http://dx.doi.org/10.4049/jimmunol.1101638DOI Listing
December 2011

IGF1 promoter polymorphism and cranial growth in individuals born very preterm.

Horm Res Paediatr 2011 31;76(1):27-34. Epub 2011 Mar 31.

Department of Clinical Epidemiology, Leiden University Medical Center, The Netherlands.

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https://www.karger.com/Article/FullText/324460
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http://dx.doi.org/10.1159/000324460DOI Listing
November 2011

Gluten-specific T cells cross-react between HLA-DQ8 and the HLA-DQ2α/DQ8β transdimer.

J Immunol 2011 Nov 17;187(10):5123-9. Epub 2011 Oct 17.

Department of Immunohematology and Blood Transfusion, Leiden University Medical Center, 2333 ZA Leiden, The Netherlands.

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http://www.jimmunol.org/lookup/doi/10.4049/jimmunol.1101179
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http://dx.doi.org/10.4049/jimmunol.1101179DOI Listing
November 2011

Preservation of recall immunity in anti-CD3-treated recent onset type 1 diabetes patients.

Diabetes Metab Res Rev 2011 Nov;27(8):925-7

Juvenile Diabetes Research Foundation Center for β-Cell Therapy in Diabetes, Leiden, The Netherlands.

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http://dx.doi.org/10.1002/dmrr.1273DOI Listing
November 2011

New hope for immune intervention therapy in type 1 diabetes.

Authors:
Bart O Roep

Lancet 2011 Jul 28;378(9789):376-8. Epub 2011 Jun 28.

Department of Immunohaematology and Blood Transfusion, Leiden University Medical Center, Leiden NL-2300RC, Netherlands.

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http://dx.doi.org/10.1016/S0140-6736(11)60977-XDOI Listing
July 2011

Beta cells under attack: toward a better understanding of type 1 diabetes immunopathology.

Semin Immunopathol 2011 Jan 18;33(1):1-7. Epub 2010 Dec 18.

La Jolla Institute for Allergy and Immunology, 9420 Athena Circle, La Jolla, CA 92037, USA.

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http://dx.doi.org/10.1007/s00281-010-0236-6DOI Listing
January 2011

Critical role for TNF in the induction of human antigen-specific regulatory T cells by tolerogenic dendritic cells.

J Immunol 2010 Aug 23;185(3):1412-8. Epub 2010 Jun 23.

Department of Immunohematology and Blood Transfusion, Leiden University Medical Center, P.O. Box 9600, 2300 RC Leiden, The Netherlands.

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http://dx.doi.org/10.4049/jimmunol.1000560DOI Listing
August 2010

Association analysis of myosin IXB and type 1 diabetes.

Hum Immunol 2010 Jun 1;71(6):598-601. Epub 2010 Apr 1.

Department Immunohematology and Blood Transfusion, Leiden University Medical Center, Leiden, The Netherlands.

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http://dx.doi.org/10.1016/j.humimm.2010.03.002DOI Listing
June 2010

Surrogate end points in the design of immunotherapy trials: emerging lessons from type 1 diabetes.

Nat Rev Immunol 2010 02;10(2):145-52

Leiden University Medical Center, National Diabetes Expert Center, Leiden, The Netherlands.

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http://dx.doi.org/10.1038/nri2705DOI Listing
February 2010

Induction of Treg by monocyte-derived DC modulated by vitamin D3 or dexamethasone: differential role for PD-L1.

Eur J Immunol 2009 Nov;39(11):3147-59

Department of Immunohematology and Blood Transfusion, Leiden University Medical Center, Leiden, The Netherlands.

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http://dx.doi.org/10.1002/eji.200839103DOI Listing
November 2009

Challenges in developing endpoints for type 1 diabetes intervention studies.

Diabetes Metab Res Rev 2009 Nov;25(8):694-704

Department of Endocrinology and Diabetes, University Campus Bio-Medico, Rome, Italy.

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http://dx.doi.org/10.1002/dmrr.1002DOI Listing
November 2009

Current advances and travails in islet transplantation.

Diabetes 2009 Oct;58(10):2175-84

National Institute of Diabetes and Digestive and Kidney Diseases/National Institutes of Health, Diabetes Branch, Bethesda, Maryland, USA.

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http://dx.doi.org/10.2337/db09-0476DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2750210PMC
October 2009

TLR triggering on tolerogenic dendritic cells results in TLR2 up-regulation and a reduced proinflammatory immune program.

J Immunol 2009 Sep 31;183(5):2984-94. Epub 2009 Jul 31.

Department of Molecular Cell Biology and Immunology, Vrije University Medical Center, Amsterdam, The Netherlands.

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http://www.jimmunol.org/cgi/doi/10.4049/jimmunol.0801155
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http://dx.doi.org/10.4049/jimmunol.0801155DOI Listing
September 2009

Immune markers of disease and therapeutic intervention in type 1 diabetes.

Authors:
Bart O Roep

Novartis Found Symp 2008 ;292:159-71; discussion 171-3, 202-3

Department of Immunohaematology and Blood Transfusion, E3-Q, Leiden University Medical Center, PO Box 9600, NL-2300 RC Leiden, The Netherlands.

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March 2009

Islet antigen specific IL-10+ immune responses but not CD4+CD25+FoxP3+ cells at diagnosis predict glycemic control in type 1 diabetes.

Clin Immunol 2008 May 4;127(2):138-43. Epub 2008 Mar 4.

Benaroya Research Institute and the University of Washington School of Medicine, 1201 9th Avenue, Seattle, WA 98101, USA.

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http://dx.doi.org/10.1016/j.clim.2007.12.003DOI Listing
May 2008

Islet autoreactive CD8 T-cells in type 1 diabetes: licensed to kill?

Authors:
Bart O Roep

Diabetes 2008 May;57(5):1156

Department of Immunohaematology & Blood Transfusion, Leiden University Medical Center, Leiden, the Netherlands.

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http://dx.doi.org/10.2337/db08-0264DOI Listing
May 2008

Association of IL-1ra and adiponectin with C-peptide and remission in patients with type 1 diabetes.

Diabetes 2008 Apr 25;57(4):929-37. Epub 2008 Feb 25.

Institute for Clinical Diabetes Research at German Diabetes Centre, Leibniz Institute at Heinrich-Heine-University Düsseldorf, Auf'm Hennekamp 65, 40225 Düsseldorf, Germany.

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http://dx.doi.org/10.2337/db07-1697DOI Listing
April 2008