Publications by authors named "Bart Ghesquière"

75Publications

ILF3 is a substrate of SPOP for regulating serine biosynthesis in colorectal cancer.

Cell Res 2020 02 26;30(2):163-178. Epub 2019 Nov 26.

Guangdong Provincial Key laboratory of Colorectal and Pelvic Floor Disease, The Sixth Affiliated Hospital of Sun Yat-sen University, 510655, Guangzhou, China.

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http://dx.doi.org/10.1038/s41422-019-0257-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7015059PMC
February 2020

Analysis of Endothelial Fatty Acid Metabolism Using Tracer Metabolomics.

Methods Mol Biol 2019 ;1978:259-268

Laboratory of Angiogenesis and Vascular Metabolism, VIB Center for Cancer Biology (CCB), VIB, Leuven, Belgium.

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http://link.springer.com/10.1007/978-1-4939-9236-2_16
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http://dx.doi.org/10.1007/978-1-4939-9236-2_16DOI Listing
November 2019

The Metabolic Map into the Pathomechanism and Treatment of PGM1-CDG.

Am J Hum Genet 2019 05 11;104(5):835-846. Epub 2019 Apr 11.

Metabolomics Expertise Center, Center for Cancer Biology, VIB Center for Cancer Biology, 3000 Leuven, Belgium; Metabolomics Expertise Center, Department of Oncology, Katholieke Universiteit Leuven, 3000 Leuven, Belgium. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S00029297193009
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http://dx.doi.org/10.1016/j.ajhg.2019.03.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6506806PMC
May 2019

Quiescent Endothelial Cells Upregulate Fatty Acid β-Oxidation for Vasculoprotection via Redox Homeostasis.

Cell Metab 2018 12 23;28(6):881-894.e13. Epub 2018 Aug 23.

Laboratory of Angiogenesis and Vascular Metabolism, VIB Center for Cancer Biology (CCB), VIB, 3000 Leuven, Belgium; State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-Sen University, Guangzhou 51006, Guangdong, P.R. China; Laboratory of Angiogenesis and Vascular Metabolism, Department of Oncology and Leuven Cancer Institute (LKI), KU Leuven, 3000 Leuven, Belgium. Electronic address:

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http://dx.doi.org/10.1016/j.cmet.2018.07.016DOI Listing
December 2018

Impairment of Angiogenesis by Fatty Acid Synthase Inhibition Involves mTOR Malonylation.

Cell Metab 2018 12 23;28(6):866-880.e15. Epub 2018 Aug 23.

Laboratory of Angiogenesis and Vascular Metabolism, VIB Center for Cancer Biology (CCB), VIB, 3000 Leuven, Belgium; State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-Sen University, Guangzhou 510060, Guangdong, P.R. China; Laboratory of Angiogenesis and Vascular Metabolism, Department of Oncology and Leuven Cancer Institute (LKI), KU Leuven, 3000 Leuven, Belgium. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S15504131183046
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http://dx.doi.org/10.1016/j.cmet.2018.07.019DOI Listing
December 2018

Serine Synthesis via PHGDH Is Essential for Heme Production in Endothelial Cells.

Cell Metab 2018 10 12;28(4):573-587.e13. Epub 2018 Jul 12.

Laboratory of Angiogenesis and Vascular Metabolism, VIB Center for Cancer Biology, VIB, Leuven 3000, Belgium; State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-Sen University, Guangzhou 510060, Guangdong, P.R. China; Laboratory of Angiogenesis and Vascular Metabolism, VIB-KU Leuven Center for Cancer Biology, Department of Oncology, KU Leuven, Leuven 3000, Belgium. Electronic address:

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http://dx.doi.org/10.1016/j.cmet.2018.06.009DOI Listing
October 2018

Consensus guidelines for the use and interpretation of angiogenesis assays.

Angiogenesis 2018 08;21(3):425-532

Angiogenesis Laboratory, Department of Medical Oncology, VU University Medical Center, Cancer Center Amsterdam, De Boelelaan 1117, 1081 HV, Amsterdam, The Netherlands.

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http://dx.doi.org/10.1007/s10456-018-9613-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6237663PMC
August 2018

Tumor vessel disintegration by maximum tolerable PFKFB3 blockade.

Angiogenesis 2017 Nov 5;20(4):599-613. Epub 2017 Sep 5.

Laboratory of Angiogenesis and Vascular Metabolism, Department of Oncology, KU Leuven, 3000, Leuven, Belgium.

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http://dx.doi.org/10.1007/s10456-017-9573-6DOI Listing
November 2017

Clinical Metabolomics and Glaucoma.

Ophthalmic Res 2018 1;59(1):1-6. Epub 2017 Sep 1.

Laboratory of Ophthalmology, Department of Neurosciences, KU Leuven, Leuven, Belgium.

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http://dx.doi.org/10.1159/000479158DOI Listing
March 2018

A Fatty Acid Oxidation-Dependent Metabolic Shift Regulates Adult Neural Stem Cell Activity.

Cell Rep 2017 Aug;20(9):2144-2155

Laboratory of Neural Plasticity, Faculty of Medicine and Science, Brain Research Institute, University of Zurich, 8057 Zurich, Switzerland. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2017.08.029DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5583518PMC
August 2017

Pharmacologic or Genetic Targeting of Glutamine Synthetase Skews Macrophages toward an M1-like Phenotype and Inhibits Tumor Metastasis.

Cell Rep 2017 08;20(7):1654-1666

Department of Biosciences, Biotechnologies and Biopharmaceutics, University of Bari, 70125 Bari, Italy; Hematology Unit, National Cancer Research Center, Istituto Tumori "Giovanni Paolo II," 70124 Bari, Italy. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2017.07.054DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5575233PMC
August 2017

Sex-specific, reciprocal regulation of ERα and miR-22 controls muscle lipid metabolism in male mice.

EMBO J 2017 05 17;36(9):1199-1214. Epub 2017 Mar 17.

Department of Cardiac Development and Remodelling, Max Planck Institute for Heart and Lung Research, Bad Nauheim, Germany

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http://dx.doi.org/10.15252/embj.201695988DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5412813PMC
May 2017

Macrophage Metabolism Controls Tumor Blood Vessel Morphogenesis and Metastasis.

Cell Metab 2016 11 20;24(5):701-715. Epub 2016 Oct 20.

Lab of Tumor Inflammation and Angiogenesis, VIB, 3000 Leuven, Belgium; Lab of Tumor Inflammation and Angiogenesis, Department of Oncology, KU Leuven, 3000 Leuven, Belgium. Electronic address:

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http://dx.doi.org/10.1016/j.cmet.2016.09.008DOI Listing
November 2016

Adequate hypoxia inducible factor 1α signaling is indispensable for bone regeneration.

Bone 2016 06 4;87:176-86. Epub 2016 Apr 4.

Laboratory of Clinical and Experimental Endocrinology, Department of Clinical and Experimental Medicine, KU Leuven, 3000 Leuven, Belgium; Prometheus, Division of Skeletal Tissue Engineering, KU Leuven, 3000 Leuven, Belgium. Electronic address:

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http://dx.doi.org/10.1016/j.bone.2016.03.014DOI Listing
June 2016

The Oxygen Sensor PHD2 Controls Dendritic Spines and Synapses via Modification of Filamin A.

Cell Rep 2016 Mar 10;14(11):2653-67. Epub 2016 Mar 10.

Laboratory of Angiogenesis and Vascular Metabolism, Department of Oncology, KU Leuven, 3000 Leuven, Belgium; Laboratory of Angiogenesis and Vascular Metabolism, Vesalius Research Center, VIB, 3000 Leuven, Belgium. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2016.02.047DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4805856PMC
March 2016

HIF-1α Promotes Glutamine-Mediated Redox Homeostasis and Glycogen-Dependent Bioenergetics to Support Postimplantation Bone Cell Survival.

Cell Metab 2016 Feb;23(2):265-79

Laboratory of Clinical and Experimental Endocrinology, Department of Clinical and Experimental Medicine, KU Leuven, 3000 Leuven, Belgium; Prometheus, Division of Skeletal Tissue Engineering, KU Leuven, 3000 Leuven, Belgium. Electronic address:

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http://dx.doi.org/10.1016/j.cmet.2016.01.002DOI Listing
February 2016

Protein Methionine Sulfoxide Dynamics in Arabidopsis thaliana under Oxidative Stress.

Mol Cell Proteomics 2015 May 18;14(5):1217-29. Epub 2015 Feb 18.

From the Department of Medical Protein Research, VIB, B-9000 Ghent, Belgium, Department of Biochemistry, Ghent University, B-9000 Ghent, Belgium,

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http://dx.doi.org/10.1074/mcp.M114.043729DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4424394PMC
May 2015

Tumor vessel normalization by chloroquine independent of autophagy.

Cancer Cell 2014 Aug;26(2):190-206

Department of Oncology, Laboratory of Angiogenesis and Neurovascular Link, KU Leuven, B-3000 Leuven, Belgium; Vesalius Research Center, Laboratory of Angiogenesis and Neurovascular Link, VIB, B-3000 Leuven, Belgium.

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http://dx.doi.org/10.1016/j.ccr.2014.06.025DOI Listing
August 2014

Metabolism of stromal and immune cells in health and disease.

Nature 2014 Jul;511(7508):167-76

1] Laboratory of Angiogenesis and Neurovascular Link, Vesalius Research Center, Department of Oncology, University of Leuven, Leuven B-3000, Belgium [2] Laboratory of Angiogenesis and Neurovascular Link, Vesalius Research Center, VIB, Leuven B-3000, Belgium.

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http://dx.doi.org/10.1038/nature13312DOI Listing
July 2014

Unraveling the specificities of the different human methionine sulfoxide reductases.

Proteomics 2014 Sep 28;14(17-18):1990-8. Epub 2014 May 28.

Department of Medical Protein Research, VIB, Ghent, Belgium; Department of Biochemistry, Ghent University, Ghent, Belgium.

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http://dx.doi.org/10.1002/pmic.201300357DOI Listing
September 2014

Partial and transient reduction of glycolysis by PFKFB3 blockade reduces pathological angiogenesis.

Cell Metab 2014 Jan 12;19(1):37-48. Epub 2013 Dec 12.

Laboratory of Angiogenesis and Neurovascular link, Vesalius Research Center, Department of Oncology, University of Leuven, Leuven 3000, Belgium; Laboratory of Angiogenesis and Neurovascular link, Vesalius Research Center, VIB, Leuven 3000, Belgium. Electronic address:

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http://dx.doi.org/10.1016/j.cmet.2013.11.008DOI Listing
January 2014

Proteomics methods to study methionine oxidation.

Mass Spectrom Rev 2014 Mar-Apr;33(2):147-56. Epub 2013 Oct 31.

Department of Medical Protein Research, VIB, B-9000, Ghent, Belgium; Department of Biochemistry, Ghent University, B-9000, Ghent, Belgium.

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http://dx.doi.org/10.1002/mas.21386DOI Listing
September 2014

High entomotoxicity and mechanism of the fungal GalNAc/Gal-specific Rhizoctonia solani lectin in pest insects.

J Insect Physiol 2013 Mar 2;59(3):295-305. Epub 2013 Jan 2.

Department of Crop Protection, Faculty of Bioscience Engineering, Ghent University, Coupure links 653, B-9000 Ghent, Belgium.

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http://dx.doi.org/10.1016/j.jinsphys.2012.12.003DOI Listing
March 2013

Plant proteins under oxidative attack.

Proteomics 2013 Mar 4;13(6):932-40. Epub 2013 Feb 4.

Department of Medical Protein Research, VIB, Ghent, Belgium.

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http://dx.doi.org/10.1002/pmic.201200237DOI Listing
March 2013

Characterization and solution structure of mouse myristoylated methionine sulfoxide reductase A.

J Biol Chem 2012 Jul 1;287(30):25589-95. Epub 2012 Jun 1.

Laboratory of Biochemistry, NHLBI, National Institutes of Health, Bethesda, Maryland 20892-8012, USA.

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http://dx.doi.org/10.1074/jbc.M112.368936DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3408158PMC
July 2012

A novel strategy for the comprehensive analysis of the biomolecular composition of isolated plasma membranes.

Mol Syst Biol 2011 Oct 25;7:541. Epub 2011 Oct 25.

Department of Molecular and Developmental Genetics (VIB11), Laboratory for Membrane Trafficking and Center for Human Genetics (KULeuven), Gasthuisberg O&N4, Leuven, Belgium.

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http://dx.doi.org/10.1038/msb.2011.74DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3261717PMC
October 2011

Diversity in protein glycosylation among insect species.

PLoS One 2011 Feb 23;6(2):e16682. Epub 2011 Feb 23.

Laboratory of Agrozoology, Department of Crop Protection, Faculty of Bioscience Engineering, Ghent University, Ghent, Belgium.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0016682PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3044136PMC
February 2011

A stringent approach to improve the quality of nitrotyrosine peptide identifications.

Proteomics 2011 Mar 7;11(6):1094-8. Epub 2011 Feb 7.

Department of Medical Protein Research, VIB, Ghent, Belgium.

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http://dx.doi.org/10.1002/pmic.201000526DOI Listing
March 2011

Interaction of the tobacco lectin with histone proteins.

Plant Physiol 2011 Mar 11;155(3):1091-102. Epub 2011 Jan 11.

Laboratory of Biochemistry and Glycobiology, Department of Molecular Biotechnology, Faculty of Bioscience Engineering, Ghent University, B-9000 Ghent, Belgium.

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http://dx.doi.org/10.1104/pp.110.170134DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3046571PMC
March 2011

Angiotensin I-converting enzyme inhibitory activity of gelatin hydrolysates and identification of bioactive peptides.

J Agric Food Chem 2011 Jan 21;59(2):552-8. Epub 2010 Dec 21.

Department of Crop Protection, Faculty of Bioscience Engineering, Ghent University, B-9000 Ghent, Belgium.

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http://dx.doi.org/10.1021/jf1037823DOI Listing
January 2011

Glycosylation signatures in Drosophila: fishing with lectins.

J Proteome Res 2010 Jun;9(6):3235-42

Laboratory of Agrozoology, Department of Crop Protection, Faculty of Bioscience Engineering, Ghent University, Coupure links 653, Ghent, Belgium.

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http://pubs.acs.org/doi/abs/10.1021/pr1001753
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http://dx.doi.org/10.1021/pr1001753DOI Listing
June 2010

Integrated proteomic analysis reveals a substantial enrichment of protein trafficking processes in hippocampus tissue after hypoxic stress.

J Proteome Res 2010 Jan;9(1):204-15

Department of Biomedical Sciences, University of Antwerp, B-2610 Antwerp, Belgium.

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http://dx.doi.org/10.1021/pr900517mDOI Listing
January 2010

Stable isotopic labeling in proteomics.

Proteomics 2008 Dec;8(23-24):4873-85

Department of Medical Protein Research, VIB, Ghent University, Ghent, Belgium.

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http://dx.doi.org/10.1002/pmic.200800421DOI Listing
December 2008

A new approach for mapping sialylated N-glycosites in serum proteomes.

J Proteome Res 2007 Nov 5;6(11):4304-12. Epub 2007 Oct 5.

Department of Medical Protein Research, VIB, B-9000 Ghent, Belgium.

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http://dx.doi.org/10.1021/pr0703728DOI Listing
November 2007

A la carte proteomics with an emphasis on gel-free techniques.

Proteomics 2007 Aug;7(16):2698-718

Department of Medical Protein Research, VIB, Ghent, Belgium.

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http://dx.doi.org/10.1002/pmic.200700114DOI Listing
August 2007

Protein processing and other modifications analyzed by diagonal peptide chromatography.

Biochim Biophys Acta 2006 Dec 14;1764(12):1801-10. Epub 2006 Sep 14.

Department of Medical Protein Research and Biochemistry, Flanders Interuniversity Institute for Biotechnology and Faculty of Medicine and Health Sciences, Ghent University, A. Baertsoenkaai 3, B-9000 Ghent, Belgium.

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http://dx.doi.org/10.1016/j.bbapap.2006.09.003DOI Listing
December 2006

Proteome-wide characterization of N-glycosylation events by diagonal chromatography.

J Proteome Res 2006 Sep;5(9):2438-47

Department of Biochemistry and Medical Protein Research, Faculty of Medicine and Health Sciences, Ghent University, A. Baertsoenkaai 3, B9000 Ghent, Belgium.

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http://dx.doi.org/10.1021/pr060186mDOI Listing
September 2006

Improved tandem mass spectrometric characterization of 3-nitrotyrosine sites in peptides.

Rapid Commun Mass Spectrom 2006 ;20(19):2885-93

Department of Medical Protein Research and Biochemistry, Flanders Interuniversity Institute for Biotechnology and Faculty of Medicine and Health Sciences, Ghent University, A. Baertsoenkaai 3, B-9000 Ghent, Belgium.

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http://dx.doi.org/10.1002/rcm.2676DOI Listing
September 2007

The human platelet proteome mapped by peptide-centric proteomics: a functional protein profile.

Proteomics 2005 Aug;5(12):3193-204

Department of Medical Protein Research, Flanders Interuniversity Institute for Biotechnology, Department of Biochemistry, Ghent University, A. Baertsoenkaai 3, B-9000 Ghent, Belgium.

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http://dx.doi.org/10.1002/pmic.200401142DOI Listing
August 2005

Reversible labeling of cysteine-containing peptides allows their specific chromatographic isolation for non-gel proteome studies.

Proteomics 2004 Apr;4(4):897-908

Department of Biochemistry, Faculty of Medicine and Health Sciences, Ghent University and Flanders Interuniversity Institute for Biotechnology, Ghent, Belgium.

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http://doi.wiley.com/10.1002/pmic.200300641
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http://dx.doi.org/10.1002/pmic.200300641DOI Listing
April 2004