Bart De Strooper

Bart De Strooper

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Bart De Strooper

Bart De Strooper

Publications by authors named "Bart De Strooper"

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Diabetes and Alzheimer's Disease: A Link not as Simple as it Seems.

Neurochem Res 2019 Jun 6;44(6):1271-1278. Epub 2018 Dec 6.

VIB Center for Brain and Disease Research, Leuven, Belgium.

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http://dx.doi.org/10.1007/s11064-018-2690-9DOI Listing
June 2019

Subtle behavioral changes and increased prefrontal-hippocampal network synchronicity in APP mice before prominent plaque deposition.

Behav Brain Res 2019 05 20;364:431-441. Epub 2017 Nov 20.

Laboratory of Biological Psychology, University of Leuven, KU Leuven, Belgium. Electronic address:

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http://dx.doi.org/10.1016/j.bbr.2017.11.017DOI Listing
May 2019

The role of astroglia in Alzheimer's disease: pathophysiology and clinical implications.

Lancet Neurol 2019 Apr 19;18(4):406-414. Epub 2019 Feb 19.

VIB Center for Brain and Disease Research, Leuven, Belgium; Department of Neurosciences, Katholieke Universiteit Leuven, Leuven, Belgium; Dementia Research Institute, University College London, London, UK. Electronic address:

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http://dx.doi.org/10.1016/S1474-4422(18)30490-3DOI Listing
April 2019

The Major Risk Factors for Alzheimer's Disease: Age, Sex, and Genes Modulate the Microglia Response to Aβ Plaques.

Cell Rep 2019 Apr;27(4):1293-1306.e6

VIB Centre for Brain Disease Research, Leuven, Belgium; University of Leuven, Department of Neurosciences and Leuven Brain Institute, Leuven, Belgium; UK Dementia Research Institute, University College London, London, UK. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2019.03.099DOI Listing
April 2019

Generation of a human induced pluripotent stem cell-based model for tauopathies combining three microtubule-associated protein TAU mutations which displays several phenotypes linked to neurodegeneration.

Alzheimers Dement 2018 10 20;14(10):1261-1280. Epub 2018 Jul 20.

Department of Development and Regeneration, Stem Cell Biology and Embryology, KU Leuven Stem Cell Institute, Leuven, Belgium; KU Leuven-Department of Neurosciences, Experimental Neurology and Leuven Research Institute for Neuroscience and Disease (LIND), Leuven, Belgium. Electronic address:

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http://dx.doi.org/10.1016/j.jalz.2018.05.007DOI Listing
October 2018

Self-Maintaining Gut Macrophages Are Essential for Intestinal Homeostasis.

Cell 2018 10 30;175(2):400-415.e13. Epub 2018 Aug 30.

Laboratory for Intestinal Neuroimmune Interactions, Translational Research Center for Gastrointestinal Disorders, Department of Chronic Diseases, Metabolism and Ageing, University of Leuven, Leuven, Belgium. Electronic address:

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http://dx.doi.org/10.1016/j.cell.2018.07.048DOI Listing
October 2018

Modulation of BACE1 Activity by Chemically Modified Aptamers.

Chembiochem 2018 04 19;19(7):754-763. Epub 2018 Feb 19.

Univ Evry, CNRS-UMR8030-Laboratoire iSSB, CEA, DRF, IG, Genoscope, Université Paris-Saclay, 5 rue Henri Desbruères, Évry, 91030, France.

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http://dx.doi.org/10.1002/cbic.201700461DOI Listing
April 2018

Modulation of γ- and β-Secretases as Early Prevention Against Alzheimer's Disease.

Biol Psychiatry 2018 02 10;83(4):320-327. Epub 2017 Aug 10.

KU Leuven Department for Neurosciences, Leuven, Belgium; VIB-KU Leuven Center for Brain and Disease Research, Leuven, Belgium.

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http://dx.doi.org/10.1016/j.biopsych.2017.08.001DOI Listing
February 2018

Synaptogyrin-3 Mediates Presynaptic Dysfunction Induced by Tau.

Neuron 2018 02 1;97(4):823-835.e8. Epub 2018 Feb 1.

VIB-KU Leuven Center for Brain & Disease Research, 3000 Leuven, Belgium; Department of Neurosciences and Leuven Brain Institute, KU Leuven, 3000 Leuven, Belgium. Electronic address:

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http://dx.doi.org/10.1016/j.neuron.2018.01.022DOI Listing
February 2018

BACE2 distribution in major brain cell types and identification of novel substrates.

Life Sci Alliance 2018 Jan 15;1(1):e201800026. Epub 2018 Feb 15.

Department of Neurosciences, Katholieke Universiteit Leuven, Leuven, Belgium.

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http://dx.doi.org/10.26508/lsa.201800026DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6238391PMC
January 2018

Noncoding RNAs in neurodegeneration.

Nat Rev Neurosci 2017 10 17;18(10):627-640. Epub 2017 Aug 17.

VIB Center for Brain and Disease Research, Herestraat 49, 3000 Leuven, Belgium.

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http://dx.doi.org/10.1038/nrn.2017.90DOI Listing
October 2017

APP mouse models for Alzheimer's disease preclinical studies.

EMBO J 2017 09 1;36(17):2473-2487. Epub 2017 Aug 1.

Laboratory for Proteolytic Neuroscience, RIKEN Brain Science Institute, Wako, Japan

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http://dx.doi.org/10.15252/embj.201797397DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5579350PMC
September 2017

Deletion of exons 9 and 10 of the Presenilin 1 gene in a patient with Early-onset Alzheimer Disease generates longer amyloid seeds.

Neurobiol Dis 2017 Aug 28;104:97-103. Epub 2017 Apr 28.

Normandie Univ, UNIROUEN, Inserm U1245, Rouen University Hospital, Department of Genetics and CNR-MAJ, Normandy Center for Genomic and Personalized Medicine, F 76000 Rouen, France. Electronic address:

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http://dx.doi.org/10.1016/j.nbd.2017.04.020DOI Listing
August 2017

Identification and characterization of Nanobodies targeting the EphA4 receptor.

J Biol Chem 2017 07 19;292(27):11452-11465. Epub 2017 May 19.

From the KU Leuven-University of Leuven, Department of Neurosciences, Experimental Neurology and Leuven Research Institute for Neuroscience and Disease (LIND), 3000 Leuven, Belgium,

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http://dx.doi.org/10.1074/jbc.M116.774141DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5500810PMC
July 2017

Alzheimer's-Causing Mutations Shift Aβ Length by Destabilizing γ-Secretase-Aβn Interactions.

Cell 2017 Jul;170(3):443-456.e14

KU Leuven-VIB Center for Brain & Disease Research, VIB, 3000 Leuven, Belgium; Department of Neurosciences, Leuven Institute for Neuroscience and Disease, KU Leuven, 3000 Leuven, Belgium. Electronic address:

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http://dx.doi.org/10.1016/j.cell.2017.07.004DOI Listing
July 2017

Phenotypic Screening Identifies Modulators of Amyloid Precursor Protein Processing in Human Stem Cell Models of Alzheimer's Disease.

Stem Cell Reports 2017 04 9;8(4):870-882. Epub 2017 Mar 9.

The Gurdon Institute and Department of Biochemistry, University of Cambridge, Cambridge CB2 1QN, UK. Electronic address:

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http://dx.doi.org/10.1016/j.stemcr.2017.02.006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5390098PMC
April 2017

Alzheimer's disease: where next for anti-amyloid therapies?

Brain 2017 04;140(4):853-855

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http://dx.doi.org/10.1093/brain/awx059DOI Listing
April 2017

Hallmarks of Alzheimer's Disease in Stem-Cell-Derived Human Neurons Transplanted into Mouse Brain.

Neuron 2017 Mar 23;93(5):1066-1081.e8. Epub 2017 Feb 23.

VIB Center for Brain and Disease Research, VIB-Leuven, 3000 Leuven, Belgium; Center for Human Genetics, Universitaire ziekenhuizen and LIND, KU Leuven, 3000 Leuven, Belgium; Institute of Neurology and Dementia Research Institute, University College London, Queen Square, WC1N 3BG London, UK. Electronic address:

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http://dx.doi.org/10.1016/j.neuron.2017.02.001DOI Listing
March 2017

microRNA-132: a key noncoding RNA operating in the cellular phase of Alzheimer's disease.

FASEB J 2017 02;31(2):424-433

Vlaams Instituut voor Biotechnologie (VIB) Center for Brain and Disease, VIB-Leuven, Leuven, Belgium;

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http://dx.doi.org/10.1096/fj.201601308DOI Listing
February 2017

PLD3 gene and processing of APP.

Nature 2017 01;541(7638):E1-E2

VIB Center for the Biology of Disease, Leuven, Belgium.

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http://www.nature.com/articles/nature21030
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http://dx.doi.org/10.1038/nature21030DOI Listing
January 2017

PARL: The mitochondrial rhomboid protease.

Semin Cell Dev Biol 2016 12 5;60:19-28. Epub 2016 Aug 5.

VIB Center for the Biology of Disease, O&N4 Herestraat 49 box 602, 3000, Leuven, Belgium; KU Leuven Center for Human Genetics, O&N4 Herestraat 49 box 602, 3000, Leuven, Belgium; UCL Institute of Neurology, University College London, WC1N 3BG, UK. Electronic address:

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http://dx.doi.org/10.1016/j.semcdb.2016.07.034DOI Listing
December 2016

Clinical phenotype and genetic associations in autosomal dominant familial Alzheimer's disease: a case series.

Lancet Neurol 2016 Dec 21;15(13):1326-1335. Epub 2016 Oct 21.

Dementia Research Centre, Department of Neurodegenerative Disease, University College London Institute of Neurology, London, UK.

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http://dx.doi.org/10.1016/S1474-4422(16)30193-4DOI Listing
December 2016

A LRRK2-Dependent EndophilinA Phosphoswitch Is Critical for Macroautophagy at Presynaptic Terminals.

Neuron 2016 Nov 6;92(4):829-844. Epub 2016 Oct 6.

VIB Center for Brain & Disease Research, Leuven Institute for Neurodegenerative Disease, 3000 Leuven, Belgium; KU Leuven, Department for Human Genetics, Leuven Institute for Neurodegenerative Disease, 3000 Leuven, Belgium. Electronic address:

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http://dx.doi.org/10.1016/j.neuron.2016.09.037DOI Listing
November 2016

Neurodegeneration: From cellular concepts to clinical applications.

Sci Transl Med 2016 11;8(364):364ps18

Baylor College of Medicine, Howard Hughes Medical Institute, and Jan and Dan Duncan Neurological Research Institute at Texas Children's Hospital, Houston, TX 77030, USA.

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http://dx.doi.org/10.1126/scitranslmed.aal2074DOI Listing
November 2016

The amyloid cascade hypothesis: are we poised for success or failure?

J Neurochem 2016 10 3;139 Suppl 2:237-252. Epub 2016 Jun 3.

VIB Center for the Biology of Disease, VIB-Leuven, Leuven, Belgium.

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http://dx.doi.org/10.1111/jnc.13632DOI Listing
October 2016

miR-132 loss de-represses ITPKB and aggravates amyloid and TAU pathology in Alzheimer's brain.

EMBO Mol Med 2016 09 1;8(9):1005-18. Epub 2016 Sep 1.

VIB Center for the Biology of Disease, Leuven, Belgium Center for Human Genetics, Universitaire ziekenhuizen and LIND, KU, Leuven, Belgium Institute of Neurology, University College London, London, UK

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http://dx.doi.org/10.15252/emmm.201606520DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5009807PMC
September 2016

Probing γ-secretase-substrate interactions at the single amino acid residue level.

EMBO J 2016 08 1;35(15):1597-9. Epub 2016 Jul 1.

VIB Center for the Biology of Disease, VIB-Leuven, Leuven, Belgium Center for Human Genetics, Universitaire Ziekenhuizen and LIND, KU Leuven, Leuven, Belgium Institute of Neurology, University College London, London, UK.

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http://dx.doi.org/10.15252/embj.201694978DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4969572PMC
August 2016

Alzheimer's disease.

Lancet 2016 Jul 24;388(10043):505-17. Epub 2016 Feb 24.

Department of Epidemiology and Biostatistics, VU University Medical Center, Amsterdam, Netherlands.

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http://dx.doi.org/10.1016/S0140-6736(15)01124-1DOI Listing
July 2016

Alzheimer's Disease Mechanisms and Emerging Roads to Novel Therapeutics.

Annu Rev Neurosci 2016 07 4;39:57-79. Epub 2016 Apr 4.

VIB Center for the Biology of Disease, Vlaams Instituut voor Biotechnologie, Leuven 3000, Belgium; email: ,

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http://dx.doi.org/10.1146/annurev-neuro-070815-014015DOI Listing
July 2016

Familial Alzheimer's Disease Mutations in Presenilin Generate Amyloidogenic Aβ Peptide Seeds.

Neuron 2016 04;90(2):410-6

VIB Center for the Biology of Disease, 3000 Leuven, Belgium; Center for Human Genetics, and Leuven Institute for Neurodegenerative Diseases (LIND), University of Leuven (KU Leuven), 3000 Leuven, Belgium; Institute of Neurology, University College London, London, WC1N 3BG, UK. Electronic address:

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http://dx.doi.org/10.1016/j.neuron.2016.03.010DOI Listing
April 2016

BACE1 Physiological Functions May Limit Its Use as Therapeutic Target for Alzheimer's Disease.

Trends Neurosci 2016 Mar 30;39(3):158-169. Epub 2016 Jan 30.

VIB Center for the Biology of Disease, 3000 Leuven, Belgium; Center for Human Genetics, Universitaire Ziekenhuizen and LIND, KU Leuven, 3000 Leuven, Belgium; Institute of Neurology, University College London, Queen Square, London WC1N 3BG, UK. Electronic address:

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http://www.cell.com/trends/neurosciences/pdf/S0166-2236(16)0
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http://linkinghub.elsevier.com/retrieve/pii/S016622361600004
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http://dx.doi.org/10.1016/j.tins.2016.01.003DOI Listing
March 2016

The Cellular Phase of Alzheimer's Disease.

Cell 2016 Feb;164(4):603-15

Center for Human Genetics, Universitaire Ziekenhuizen and LIND, KU Leuven, 3000 Leuven, Belgium; Institute of Neurology, University College London, Queen Square, WC1N 3BG London, UK; Alzheimer Research UK, Cambridge, CB21 6AD, UK.

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http://dx.doi.org/10.1016/j.cell.2015.12.056DOI Listing
February 2016

On the identification of low allele frequency mosaic mutations in the brains of Alzheimer's disease patients.

Alzheimers Dement 2015 Nov 29;11(11):1265-76. Epub 2015 Apr 29.

VIB Center for the Biology of Disease, KU Leuven, Leuven, Belgium; Center for Human Genetics, KU Leuven, Leuven, Belgium; Department of Molecular Neuroscience, University College London (UCL) Institute of Neurology, London, UK. Electronic address:

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http://dx.doi.org/10.1016/j.jalz.2015.02.007DOI Listing
November 2015

Qualitative changes in human γ-secretase underlie familial Alzheimer's disease.

J Exp Med 2015 Nov 19;212(12):2003-13. Epub 2015 Oct 19.

VIB Center for the Biology of Disease, University of Leuven (KU Leuven), 3000 Leuven, Belgium Center for Human Genetics (CME) and Leuven Research Institute for Neuroscience and Disease (LIND), University of Leuven (KU Leuven), 3000 Leuven, Belgium

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http://dx.doi.org/10.1084/jem.20150892DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4647268PMC
November 2015

Learning by failing: ideas and concepts to tackle γ-secretases in Alzheimer's disease and beyond.

Annu Rev Pharmacol Toxicol 2015 1;55:419-37. Epub 2014 Oct 1.

VIB Center for the Biology of Disease, Vlaams Instituut voor Biotechnologie, BE-3000 Leuven, Belgium.

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http://dx.doi.org/10.1146/annurev-pharmtox-010814-124309DOI Listing
September 2015

Antagonistic Effects of BACE1 and APH1B-γ-Secretase Control Axonal Guidance by Regulating Growth Cone Collapse.

Cell Rep 2015 Sep 20;12(9):1367-76. Epub 2015 Aug 20.

VIB Center for the Biology of Disease, VIB-Leuven 3000, Belgium; Center for Human Genetics, Universitaire ziekenhuizen and LIND, KU Leuven, Leuven 3000, Belgium; Institute of Neurology, University College London, Queen Square, WC1N 3BG London, UK. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2015.07.059DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4820248PMC
September 2015

Amyloid β Oligomers Disrupt Blood-CSF Barrier Integrity by Activating Matrix Metalloproteinases.

J Neurosci 2015 Sep;35(37):12766-78

Inflammation Research Center, VIB, B-9052 Ghent, Belgium, Department of Biomedical Molecular Biology, Ghent University, B-9052 Ghent, Belgium,

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http://dx.doi.org/10.1523/JNEUROSCI.0006-15.2015DOI Listing
September 2015

Dysregulated ADAM10-Mediated Processing of APP during a Critical Time Window Leads to Synaptic Deficits in Fragile X Syndrome.

Neuron 2015 Jul;87(2):382-98

Center for Human Genetics and Leuven Research Institute for Neuroscience and Disease (LIND), KU Leuven, 3000 Leuven, Belgium; VIB Center for the Biology of Disease, 3000 Leuven, Belgium; Department of Biomedicine and Prevention, University of Rome Tor Vergata, 00133 Rome, Italy. Electronic address:

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http://dx.doi.org/10.1016/j.neuron.2015.06.032DOI Listing
July 2015

Synaptic Contacts Enhance Cell-to-Cell Tau Pathology Propagation.

Cell Rep 2015 May 14;11(8):1176-83. Epub 2015 May 14.

Neuroscience Department, Janssen Research and Development, a Division of Janssen Pharmaceutica NV, 2340 Beerse, Belgium. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2015.04.043DOI Listing
May 2015

miR-29a maintains mouse hematopoietic stem cell self-renewal by regulating Dnmt3a.

Blood 2015 Apr 29;125(14):2206-16. Epub 2015 Jan 29.

Human Oncology and Pathogenesis Program, Sloan-Kettering Cancer Center, New York, NY; Departments of Pathology and Laboratory Medicine, Memorial Sloan Kettering Cancer Center, New York, NY.

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http://dx.doi.org/10.1182/blood-2014-06-585273DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4383797PMC
April 2015

PINK1 activation-turning on a promiscuous kinase.

Biochem Soc Trans 2015 Apr;43(2):280-6

*Center for Human Genetics, LIND and KU Leuven, O&N1 Herestraat 49 box 602, 3000 Leuven, Belgium.

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http://dx.doi.org/10.1042/BST20150002DOI Listing
April 2015

Assay to probe proteolytic processing of Notch by γ-secretase.

Methods Mol Biol 2014 ;1187:223-9

VIB Center for the Biology of Disease - VIB11 and Center for Human Genetics, VIB and KU Leuven, O&N 4, Herestraat 49, 602, Leuven, 3000, Belgium.

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http://dx.doi.org/10.1007/978-1-4939-1139-4_17DOI Listing
March 2015

Small molecules that inhibit Notch signaling.

Methods Mol Biol 2014 ;1187:311-22

VIB Center for the Biology of Disease, O&N 4, Herestraat 49, 602, Leuven, 3000, Belgium.

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http://dx.doi.org/10.1007/978-1-4939-1139-4_23DOI Listing
March 2015

Deficiency of the miR-29a/b-1 cluster leads to ataxic features and cerebellar alterations in mice.

Neurobiol Dis 2015 Jan 12;73:275-88. Epub 2014 Oct 12.

VIB Center for the Biology of Disease, VIB Leuven 3000 Leuven, Belgium; Center for Human Genetics and Leuven institute for neurodegenerative disorders (LIND), KU Leuven and Universitaire Ziekenhuizen, 3000 Leuven, Belgium; Department of Molecular Neuroscience, UCL Institute of Neurology, WC1N 3BG London, UK. Electronic address:

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http://dx.doi.org/10.1016/j.nbd.2014.10.006DOI Listing
January 2015

PINK1 kinase catalytic activity is regulated by phosphorylation on serines 228 and 402.

J Biol Chem 2015 Jan 19;290(5):2798-811. Epub 2014 Dec 19.

From the Center for the Biology of Disease, Flemish Institute for Biotechnology (VIB) and Center for Human Genetics, Leuven Institute for Neurodegenerative Disorders and University Hospitals Leuven, University of Leuven, 3000 Leuven, Belgium and

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http://dx.doi.org/10.1074/jbc.M114.620906DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4317039PMC
January 2015

The Alzheimer disease protective mutation A2T modulates kinetic and thermodynamic properties of amyloid-β (Aβ) aggregation.

J Biol Chem 2014 Nov 24;289(45):30977-89. Epub 2014 Sep 24.

From the VIB Center for the Biology of Disease, the Center for Human Genetics and Leuven Institute for Neurodegenerative Diseases, University of Leuven,

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http://dx.doi.org/10.1074/jbc.M114.599027DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4223304PMC
November 2014

Lessons from a failed γ-secretase Alzheimer trial.

Authors:
Bart De Strooper

Cell 2014 Nov;159(4):721-6

VIB Center for the Biology of Disease, Leuven 3000, Belgium; KU Leuven Center for Human Genetics and Leuven Institute for Neurodegenerative disorders (LIND), University of Leuven 3000, Belgium; UCL Institute of Neurology, University College London, Queen Square, London WC1N 1PJ, UK. Electronic address:

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http://dx.doi.org/10.1016/j.cell.2014.10.016DOI Listing
November 2014

Gene and MicroRNA transcriptome analysis of Parkinson's related LRRK2 mouse models.

PLoS One 2014 10;9(1):e85510. Epub 2014 Jan 10.

Centre de recherche du CHU de Québec, CHUL, Québec, Québec, Canada ; Département de psychiatrie et de neurosciences, Université Laval, Québec, Québec, Canada.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0085510PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3888428PMC
October 2014

The deubiquitinase USP15 antagonizes Parkin-mediated mitochondrial ubiquitination and mitophagy.

Hum Mol Genet 2014 Oct 22;23(19):5227-42. Epub 2014 May 22.

Laboratory for Parkinson Research, Department of Neurosciences Department of Neurology, University Hospitals Leuven, Leuven 3000, Belgium

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http://hmg.oxfordjournals.org/content/early/2014/05/22/hmg.d
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http://www.hmg.oxfordjournals.org/cgi/doi/10.1093/hmg/ddu244
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http://dx.doi.org/10.1093/hmg/ddu244DOI Listing
October 2014

Regulation of amyloid precursor protein processing by serotonin signaling.

PLoS One 2014 21;9(1):e87014. Epub 2014 Jan 21.

KU Leuven Center for Human Genetics and Leuven research Institute for Neuroscience and Disease (LIND), Leuven, Belgium ; VIB Center for the Biology of Disease, Leuven, Belgium.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0087014PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3897773PMC
September 2014

Variance in the identification of microRNAs deregulated in Alzheimer's disease and possible role of lincRNAs in the pathology: the need of larger datasets.

Ageing Res Rev 2014 Sep 4;17:43-53. Epub 2014 Mar 4.

VIB Center for the Biology of Disease, 3000 Leuven, Belgium; Center for Human Genetics, Leuven Institute for Neurodegenerative Disorders (LIND) and University of Leuven, O&N4, Herestraat 49 Box 602, 3000 Leuven, Belgium; Department of Molecular Neuroscience, University College London (UCL) Institute of Neurology, London, United Kingdom. Electronic address:

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http://dx.doi.org/10.1016/j.arr.2014.02.006DOI Listing
September 2014

A self-organizing miR-132/Ctbp2 circuit regulates bimodal notch signals and glial progenitor fate choice during spinal cord maturation.

Dev Cell 2014 Aug 14;30(4):423-36. Epub 2014 Aug 14.

VIB Center for the Biology of Disease, 3000 Leuven, Belgium; Center for Human Genetics and Leuven Institute for Neurodegenerative Disorders, KU Leuven, 3000 Leuven, Belgium; Institute of Neurology, University College London, Queen Square, WC1N 3BG London, UK. Electronic address:

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http://dx.doi.org/10.1016/j.devcel.2014.07.006DOI Listing
August 2014

Near-infrared 808 nm light boosts complex IV-dependent respiration and rescues a Parkinson-related pink1 model.

PLoS One 2013 11;8(11):e78562. Epub 2013 Nov 11.

VIB Center for the Biology of Disease, Leuven, Belgium ; KU Leuven, Department of Human Genetics and Leuven Research Institute for Neuroscience and Disease (LIND), Leuven, Belgium.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0078562PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3823844PMC
July 2014

When the dust settles: what did we learn from the bexarotene discussion?

Alzheimers Res Ther 2013 7;5(6):54. Epub 2013 Nov 7.

VIB Center for the Biology of Disease, Herestraat 49, box 602, Leuven BE3000, Belgium ; Center for Human Genetics and Institute of Neuroscience and Disease (LIND), KU Leuven and Universitaire Ziekenhuizen, Leuven B-3000, Belgium.

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http://dx.doi.org/10.1186/alzrt218DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3979032PMC
May 2014

Amyloid and tau neuropathology differentially affect prefrontal synaptic plasticity and cognitive performance in mouse models of Alzheimer's disease.

J Alzheimers Dis 2013 ;37(1):109-25

Laboratory of Biological Psychology and Leuven Institute for Neuroscience & Disease, University of Leuven, Leuven, Belgium.

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http://dx.doi.org/10.3233/JAD-122296DOI Listing
April 2014

Epigenetically regulated microRNAs in Alzheimer's disease.

Neurobiol Aging 2014 Apr 18;35(4):731-45. Epub 2013 Oct 18.

School for Mental Health and Neuroscience (MHeNS), Faculty of Health, Medicine, and Life Sciences, European Graduate School of Neuroscience (EURON), Maastricht University Medical Centre, Maastricht, the Netherlands.

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http://dx.doi.org/10.1016/j.neurobiolaging.2013.10.082DOI Listing
April 2014

Signature amyloid β profiles are produced by different γ-secretase complexes.

J Biol Chem 2014 Feb 13;289(7):4346-55. Epub 2013 Dec 13.

From the Center for the Biology of Disease, Flemish Institute for Biology (VIB), 3000 Leuven, Belgium.

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http://dx.doi.org/10.1074/jbc.M113.530907DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3924297PMC
February 2014

Dose-dependent improvements in learning and memory deficits in APPPS1-21 transgenic mice treated with the orally active Aβ toxicity inhibitor SEN1500.

Neuropharmacology 2013 Dec 10;75:458-66. Epub 2013 Sep 10.

Laboratory of Biological Psychology, University of Leuven, Belgium; Leuven Institute for Neuroscience & Disease (LIND), Belgium. Electronic address:

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http://dx.doi.org/10.1016/j.neuropharm.2013.08.030DOI Listing
December 2013

Reduced expression of hsa-miR-27a-3p in CSF of patients with Alzheimer disease.

Neurology 2013 Dec 8;81(24):2103-6. Epub 2013 Nov 8.

From the VIB Center for the Biology of Disease (C.S.F., P.L., E.S., B.D.S.), Leuven; Center for Human Genetics and LIND (C.S.F., P.L., E.S., B.D.S.), and Alzheimer Research Centre KU Leuven, Leuven Institute for Neuroscience and Disease (R.V.), University of Leuven; Geriatric Medicine (J.T.), and Neurology Department (R.V.), University Hospitals Leuven; Department of Clinical and Experimental Medicine and LIND (J.T.), Laboratory for Cognitive Neurology, Department of Neurosciences (R.V.), KU Leuven, Belgium; Netherlands Institute for Neuroscience (K.B.), Amsterdam, the Netherlands; Clinical Neurochemistry Laboratory (A.W., M.B., H.Z., K.B.), Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry, The Sahlgrenska Academy at the University of Gothenburg, Mölndal, Sweden; and UCL Institute of Neurology (H.Z.), Queen Square, London, UK.

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http://www.neurology.org/cgi/doi/10.1212/01.wnl.0000437306.3
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December 2013

Soluble amyloid-β precursor protein binds its cell surface receptor in a cooperative fashion with glypican and syndecan proteoglycans.

J Cell Sci 2013 Nov 28;126(Pt 21):4856-61. Epub 2013 Aug 28.

VIB Center for the Biology of Disease, VIB, B-3000 Leuven, Belgium.

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http://dx.doi.org/10.1242/jcs.137919DOI Listing
November 2013

Alteration of the microRNA network during the progression of Alzheimer's disease.

EMBO Mol Med 2013 10 9;5(10):1613-34. Epub 2013 Sep 9.

VIB Center for the Biology of Disease, Leuven, Belgium; Center for Human Genetics, Leuven Institute for Neurodegenerative Disorders (LIND) University Hospitals Leuven, and University of Leuven, O&N4, Herestraat, Leuven, Belgium.

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http://dx.doi.org/10.1002/emmm.201201974DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3799583PMC
October 2013

Neuroscience. Promiscuous Alzheimer's amyloid: yet another partner.

Science 2013 Sep;341(6152):1354-5

Vlaams Instituut voor Biotechnologie Center for the Biology of Disease, 3000 Leuven, Belgium.

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http://dx.doi.org/10.1126/science.1244166DOI Listing
September 2013

BACE2 processes PMEL to form the melanosome amyloid matrix in pigment cells.

Proc Natl Acad Sci U S A 2013 Jun 10;110(26):10658-63. Epub 2013 Jun 10.

Institut Curie, and Unité Mixte de Recherche 144, Centre National de la Recherche Scientifique, F-75248 Paris, France.

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http://www.pnas.org/content/110/26/10658.full.pdf
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http://www.pnas.org/cgi/doi/10.1073/pnas.1220748110
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http://dx.doi.org/10.1073/pnas.1220748110DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3696817PMC
June 2013