Publications by authors named "Bart De Strooper"

273Publications

Reactive astrocyte nomenclature, definitions, and future directions.

Nat Neurosci 2021 Feb 15. Epub 2021 Feb 15.

Faculty of Biology, Medicine and Health, The University of Manchester, Manchester, UK.

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February 2021

Dementia and COVID-19: a health and research funding crisis.

Lancet Neurol 2021 02 20;20(2):90. Epub 2021 Jan 20.

VIB-KU Leuven Center for Brain and Disease Research, and Department of Neurosciences, Leuven Brain Institute, KU Leuven, Belgium; UK Dementia Research Institute, University College London WC1E 6BT, London, UK. Electronic address:

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February 2021

Lowering Synaptogyrin-3 expression rescues Tau-induced memory defects and synaptic loss in the presence of microglial activation.

Neuron 2021 Jan 7. Epub 2021 Jan 7.

VIB-KU Leuven Center for Brain & Disease Research, Leuven, Belgium; KU Leuven, Department of Neurosciences, Leuven Brain Institute, Mission Lucidity, Leuven, Belgium. Electronic address:

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January 2021

Stem-cell-derived human microglia transplanted into mouse brain to study human disease.

Nat Protoc 2021 Feb 11;16(2):1013-1033. Epub 2021 Jan 11.

Centre for Brain and Disease Research, Flanders Institute for Biotechnology (VIB), Leuven, Belgium.

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February 2021

The App mouse retina is a site for preclinical Alzheimer's disease diagnosis and research.

Acta Neuropathol Commun 2021 01 6;9(1). Epub 2021 Jan 6.

Neural Circuit Development and Regeneration Research Group, Department of Biology, University of Leuven (KU Leuven), Naamsestraat 61, Box 2464, 3000, Leuven, Belgium.

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January 2021

Computational Analysis of Alzheimer Amyloid Plaque Composition in 2D- and Elastically Reconstructed 3D-MALDI MS Images.

Anal Chem 2020 11 14;92(21):14484-14493. Epub 2020 Oct 14.

Center for Mass Spectrometry and Optical Spectroscopy (CeMOS), Mannheim University of Applied Sciences, Paul-Wittsack Str. 10, Mannheim 68163, Germany.

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November 2020

Modeling the β-secretase cleavage site and humanizing amyloid-beta precursor protein in rat and mouse to study Alzheimer's disease.

Mol Neurodegener 2020 10 19;15(1):60. Epub 2020 Oct 19.

Centre for Brain and Disease Research, Flanders Institute for Biotechnology (VIB), Leuven, Belgium.

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October 2020

Single-Nucleus RNA-Seq Is Not Suitable for Detection of Microglial Activation Genes in Humans.

Cell Rep 2020 09;32(13):108189

Centre for Brain and Disease Research, Flanders Institute for Biotechnology (VIB), Leuven, Belgium; Department of Neurosciences and Leuven Brain Institute, KU Leuven, Leuven, Belgium; UK Dementia Research Institute at University College London, University College London, London, UK. Electronic address:

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September 2020

Mixing Aβ(1-40) and Aβ(1-42) peptides generates unique amyloid fibrils.

Chem Commun (Camb) 2020 Aug 6;56(62):8830-8833. Epub 2020 Jul 6.

Magnetic Resonance Center (CERM), University of Florence and Interuniversity Consortium for Magnetic Resonance of Metalloproteins (CIRMMP), Via L. Sacconi 6, 50019, Sesto Fiorentino (FI), Italy.

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August 2020

Spatial Transcriptomics and In Situ Sequencing to Study Alzheimer's Disease.

Cell 2020 Aug 22;182(4):976-991.e19. Epub 2020 Jul 22.

VIB Center for Brain & Disease Research, Leuven 3000, Belgium; KU Leuven, Department of Neurosciences, Leuven Brain Institute, Leuven 3000, Belgium; UK Dementia Research Institute at University College London, London WC1E 6BT, UK. Electronic address:

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August 2020

Microglia Require CD4 T Cells to Complete the Fetal-to-Adult Transition.

Cell 2020 Aug 22;182(3):625-640.e24. Epub 2020 Jul 22.

VIB Center for Brain and Disease Research, VIB, Leuven 3000, Belgium; Department of Microbiology and Immunology, KU Leuven-University of Leuven, Leuven 3000, Belgium; Laboratory of Lymphocyte Signalling and Development, The Babraham Institute, Cambridge CB22 3AT, UK. Electronic address:

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August 2020

Tipping the Scales: Peptide-Dependent Dysregulation of Neural Circuit Dynamics in Alzheimer's Disease.

Neuron 2020 08 23;107(3):417-435. Epub 2020 Jun 23.

UK Dementia Research Institute at UCL, University College London, WC1E 6BT London, UK. Electronic address:

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August 2020

The β-Secretase BACE1 in Alzheimer's Disease.

Biol Psychiatry 2020 Feb 13. Epub 2020 Feb 13.

From the Neurology Business Group, Eisai Inc., Woodcliff Lake, New Jersey; Sorbonne University, GRC No. 21, Alzheimer Precision Medicine, Pitié-Salpêtrière Hospital, Paris, France; Institute of Memory and Alzheimer's Disease, Department of Neurology, Pitié-Salpêtrière Hospital, Paris, France; Brain & Spine Institute, INSERM U 1127, CNRS UMR 7225, Paris, France. Electronic address:

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February 2020