Dr. Barry L Wanner, PhD - Harvard Medical School - Lecturer

Dr. Barry L Wanner

PhD

Harvard Medical School

Lecturer

Boston, MA | United States

Main Specialties: Biology

Additional Specialties: Synthetic Biology

Dr. Barry L Wanner, PhD - Harvard Medical School - Lecturer

Dr. Barry L Wanner

PhD

Introduction

Primary Affiliation: Harvard Medical School - Boston, MA , United States

Specialties:

Additional Specialties:

Publications

38Publications

907Reads

-Profile Views

4164PubMed Central Citations

Development of a system for discovery of genetic interactions for essential genes in Escherichia coli K-12.

Genes Genet Syst 2013 ;88(4):233-40

Graduate School of Biological Science, Nara Institute of Science and Technology.

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http://dx.doi.org/10.1266/ggs.88.233DOI Listing
September 2014
53 Reads
1 Citation
0.930 Impact Factor

Unprecedented high-resolution view of bacterial operon architecture revealed by RNA sequencing.

mBio 2014 Jul 8;5(4):e01442-14. Epub 2014 Jul 8.

Department of Biological Sciences, Purdue University, West Lafayette, Indiana, USA

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http://dx.doi.org/10.1128/mBio.01442-14DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4161252PMC
July 2014
61 Reads
37 Citations
6.790 Impact Factor

Colony-live--a high-throughput method for measuring microbial colony growth kinetics--reveals diverse growth effects of gene knockouts in Escherichia coli.

BMC Microbiol 2014 Jun 26;14:171. Epub 2014 Jun 26.

Graduate School of Biological Sciences, Nara Institute of Science and Technology, Ikoma, Nara, Japan.

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http://dx.doi.org/10.1186/1471-2180-14-171DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4096534PMC
June 2014
13 Reads
9 Citations
2.730 Impact Factor

What hath DNA wrought? CRISPR-CAS gene silencing and engineering from bacteria to humans: comment on "Diversity, evolution, and therapeutic applications of small RNAs in prokaryotic and eukaryotic immune systems" by Edwin L. Cooper and Nicola Overstreet.

Phys Life Rev 2014 Mar 12;11(1):144-5; discussion 149-51. Epub 2013 Dec 12.

Graduate School of Biological Sciences, Nara Institute of Science and Technology, Ikoma, Nara, Japan.

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http://dx.doi.org/10.1016/j.plrev.2013.12.003DOI Listing
March 2014
9 Reads
7.480 Impact Factor

Dynamics of the serine chemoreceptor in the Escherichia coli inner membrane: a high-speed single-molecule tracking study.

Biophys J 2014 Jan;106(1):145-53

Department of Physics, Purdue University, West Lafayette, Indiana. Electronic address:

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http://dx.doi.org/10.1016/j.bpj.2013.09.059DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3907255PMC
January 2014
5 Reads
11 Citations
3.972 Impact Factor

The tRNA thiolation pathway modulates the intracellular redox state in Escherichia coli.

J Bacteriol 2013 May 1;195(9):2039-49. Epub 2013 Mar 1.

Graduate School of Biological Sciences, Nara Institute of Science and Technology, Ikoma, Nara, Japan.

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http://dx.doi.org/10.1128/JB.02180-12DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3624572PMC
May 2013
44 Reads
7 Citations
2.810 Impact Factor

Molecular memory of prior infections activates the CRISPR/Cas adaptive bacterial immunity system.

Nat Commun 2012 Jul 10;3:945. Epub 2012 Jul 10.

Waksman Institute, Piscataway, New Jersey 08854, USA.

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http://dx.doi.org/10.1038/ncomms1937DOI Listing
July 2012
85 Reads
175 Citations
10.742 Impact Factor

Characterization of peptide chain length and constituency requirements for YejABEF-mediated uptake of microcin C analogues.

J Bacteriol 2011 Jul 20;193(14):3618-23. Epub 2011 May 20.

Laboratory of Medicinal Chemistry, Rega Institute for Medical Research, Katholieke Universiteit Leuven, Minderbroedersstraat 10, B-3000 Leuven, Belgium.

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http://dx.doi.org/10.1128/JB.00172-11DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3133342PMC
July 2011
31 Reads
9 Citations
2.810 Impact Factor

Welcome to microbial informatics and experimentation.

Microb Inform Exp 2011 Jun 14;1(1). Epub 2011 Jun 14.

Biomolecular, Biomedical and Chemical Sciences, M310, University of Western Australia, Crawley WA 6009, Australia.

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http://dx.doi.org/10.1186/2042-5783-1-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3298189PMC
June 2011
3 Reads

Environmental dependency of gene knockouts on phenotype microarray analysis in Escherichia coli.

J Bioinform Comput Biol 2010 Dec;8 Suppl 1:83-99

Department of Bioinformatics, Ritsumeikan University, Kusatu, Shiga, Japan.

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http://dx.doi.org/10.1142/s021972001000521xDOI Listing
December 2010
6 Reads
4 Citations
0.931 Impact Factor

Transcription, processing and function of CRISPR cassettes in Escherichia coli.

Mol Microbiol 2010 Sep;77(6):1367-79

Institutes of Molecular Genetics and Gene Biology, Russian Academy of Sciences, Moscow, Russia.

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http://dx.doi.org/10.1111/j.1365-2958.2010.07265.xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2939963PMC
September 2010
17 Reads
79 Citations
4.420 Impact Factor

Global regulation by the seven-component Pi signaling system.

Curr Opin Microbiol 2010 Apr 18;13(2):198-203. Epub 2010 Feb 18.

Department of Biological Sciences, Purdue University, West Lafayette, IN 47907, USA.

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http://dx.doi.org/10.1016/j.mib.2010.01.014DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2847643PMC
April 2010
14 Reads
95 Citations
5.900 Impact Factor

Stochastic kinetic model of two component system signalling reveals all-or-none, graded and mixed mode stochastic switching responses.

Mol Biosyst 2010 Mar 2;6(3):531-42. Epub 2009 Dec 2.

Faculty of Health and Medical Sciences, University of Surrey, Guildford, Surrey, UK GU2 7XH.

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http://dx.doi.org/10.1039/b906951hDOI Listing
March 2010
3 Reads
8 Citations

Evidence against the physiological role of acetyl phosphate in the phosphorylation of the ArcA response regulator in Escherichia coli.

J Microbiol 2009 Oct 24;47(5):657-62. Epub 2009 Oct 24.

Department of Microbiology and Molecular Genetics, Harvard Medical School, Boston, MA 02115, USA.

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http://dx.doi.org/10.1007/s12275-009-0087-9DOI Listing
October 2009
5 Reads
6 Citations
1.440 Impact Factor

Genome-wide screens: novel mechanisms in colicin import and cytotoxicity.

Mol Microbiol 2009 Aug 22;73(4):571-85. Epub 2009 Jul 22.

Department of Biological Sciences, Lilly Hall of Life Sciences, Purdue University, West Lafayette, IN 47907, USA.

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http://dx.doi.org/10.1111/j.1365-2958.2009.06788.xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3100173PMC
August 2009
22 Reads
11 Citations
4.420 Impact Factor

In vivo recognition of Bacillus subtilis by desorption electrospray ionization mass spectrometry (DESI-MS).

Analyst 2009 May 16;134(5):838-41. Epub 2009 Mar 16.

Department of Chemistry, Purdue University, West Lafayette, IN 47907, USA.

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http://dx.doi.org/10.1039/b900069kDOI Listing
May 2009
5 Reads
8 Citations
4.110 Impact Factor

High-throughput, quantitative analyses of genetic interactions in E. coli.

Nat Methods 2008 Sep;5(9):781-7

Department of Microbiology and Immunology, University of California at San Francisco, 600 16th Street, San Francisco, California 94158, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2700713PMC
http://dx.doi.org/10.1038/nmeth.1240DOI Listing
September 2008
15 Reads
94 Citations
32.072 Impact Factor

The applications of systematic in-frame, single-gene knockout mutant collection of Escherichia coli K-12.

Methods Mol Biol 2008 ;416:183-94

Graduate School of Biological Sciences, Nara Institute of Science and Technology, Ikoma, Nara, Japan.

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http://dx.doi.org/10.1007/978-1-59745-321-9_12DOI Listing
June 2008
12 Reads
17 Citations

The phosphate regulon and bacterial virulence: a regulatory network connecting phosphate homeostasis and pathogenesis.

FEMS Microbiol Rev 2008 May 29;32(3):461-73. Epub 2008 Jan 29.

Groupe de Recherche sur les Maladies Infectieuses du Porc, Faculté de médecine vétérinaire, Université de Montréal, Saint-Hyacinthe, Québec, Canada.

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http://dx.doi.org/10.1111/j.1574-6976.2008.00101.xDOI Listing
May 2008
1 Read
130 Citations
13.244 Impact Factor

Escherichia coli peptidase A, B, or N can process translation inhibitor microcin C.

J Bacteriol 2008 Apr 25;190(7):2607-10. Epub 2008 Jan 25.

Institute of Molecular Genetics, Russian Academy of Sciences, Moscow 123182, Russia.

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http://dx.doi.org/10.1128/JB.01956-07DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2293190PMC
April 2008
46 Reads
19 Citations
2.810 Impact Factor

Analysis of promoter targets for Escherichia coli transcription elongation factor GreA in vivo and in vitro.

J Bacteriol 2007 Dec 31;189(24):8772-85. Epub 2007 Aug 31.

Department of Cell Biology, UMDNJ-SOM at Stratford, 2 Medical Center Drive, Stratford, NJ 08084-1489, USA.

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http://dx.doi.org/10.1128/JB.00911-07DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2168603PMC
December 2007
19 Reads
37 Citations
2.810 Impact Factor

Structure of the complex of the colicin E2 R-domain and its BtuB receptor. The outer membrane colicin translocon.

J Biol Chem 2007 Aug 4;282(32):23163-70. Epub 2007 Jun 4.

Department of Biological Sciences, Lilly Hall of Life Sciences, Purdue University, West Lafayette, Indiana 47907, USA.

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http://dx.doi.org/10.1074/jbc.M703004200DOI Listing
August 2007
6 Reads
23 Citations
4.573 Impact Factor

The X-ray crystal structures of two constitutively active mutants of the Escherichia coli PhoB receiver domain give insights into activation.

J Mol Biol 2007 Feb 14;366(2):626-41. Epub 2006 Nov 14.

Institut de Biologia Molecular de Barcelona (CSIC), c/Jordi Girona 18-26, 08034 Barcelona, Spain.

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http://dx.doi.org/10.1016/j.jmb.2006.11.038DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1855202PMC
February 2007
4 Reads
16 Citations
4.333 Impact Factor

The pathogen-associated iroA gene cluster mediates bacterial evasion of lipocalin 2.

Proc Natl Acad Sci U S A 2006 Oct 23;103(44):16502-7. Epub 2006 Oct 23.

Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA 02115, USA.

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http://dx.doi.org/10.1073/pnas.0604636103DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1637611PMC
October 2006
40 Reads
109 Citations
9.810 Impact Factor

Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110.

Mol Syst Biol 2006 21;2:2006.0007. Epub 2006 Feb 21.

Division of Genome Dynamics, National Institute for Basic Biology, Myodaiji, Okazaki, Aichi Pref., Japan.

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http://dx.doi.org/10.1038/msb4100049DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1681481PMC
August 2006
17 Reads
151 Citations
10.872 Impact Factor

Chromosomal expression of foreign and native genes from regulatable promoters in Escherichia coli.

Methods Mol Biol 2004 ;267:123-34

Department of Biological Sciences, Purdue University, West Lafayette, IN, USA.

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http://dx.doi.org/10.1385/1-59259-774-2:123DOI Listing
October 2004
2 Reads
2 Citations

Genome-scale identification of conditionally essential genes in E. coli by DNA microarrays.

Biochem Biophys Res Commun 2004 Sep;322(1):347-54

Department of Pathology, Northwestern University, Chicago, IL 60611, USA.

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http://dx.doi.org/10.1016/j.bbrc.2004.07.110DOI Listing
September 2004
6 Reads
12 Citations
2.300 Impact Factor

Phenotype microarray analysis of Escherichia coli K-12 mutants with deletions of all two-component systems.

J Bacteriol 2003 Aug;185(16):4956-72

Department of Biological Sciences, Purdue University, West Lafayette, Indiana 47907, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC166450PMC
http://dx.doi.org/10.1128/jb.185.16.4956-4972.2003DOI Listing
August 2003
1 Read
122 Citations
2.810 Impact Factor

Functional genomics by NMR spectroscopy. Phenylacetate catabolism in Escherichia coli.

Eur J Biochem 2003 Jul;270(14):3047-54

Mikrobiologie, Institut für Biologie II, Universität Freiburg, Germany.

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http://dx.doi.org/10.1046/j.1432-1033.2003.03683.xDOI Listing
July 2003
6 Reads
27 Citations

Escherichia coli phnN, encoding ribose 1,5-bisphosphokinase activity (phosphoribosyl diphosphate forming): dual role in phosphonate degradation and NAD biosynthesis pathways.

J Bacteriol 2003 May;185(9):2793-801

Department of Biological Chemistry, Institute of Molecular Biology, University of Copenhagen, Copenhagen, Denmark.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC154390PMC
http://dx.doi.org/10.1128/jb.185.9.2793-2801.2003DOI Listing
May 2003
6 Reads
23 Citations
2.810 Impact Factor

Transcriptome analysis of all two-component regulatory system mutants of Escherichia coli K-12.

Mol Microbiol 2002 Oct;46(1):281-91

Research and Education Center for Genetic Information, Nara Institute of Science and Technology, Ikoma 630-0101, Japan.

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http://dx.doi.org/10.1046/j.1365-2958.2002.03170.xDOI Listing
October 2002
6 Reads
133 Citations
4.420 Impact Factor