Barbara S Nikolajczyk

Barbara S Nikolajczyk

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Barbara S Nikolajczyk

Barbara S Nikolajczyk

Publications by authors named "Barbara S Nikolajczyk"

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Origin of Th17 Cells in Type 2 Diabetes-Potentiated Periodontal Disease.

Adv Exp Med Biol 2019 ;1197:45-54

Department of Oral Health Practice, Division of Periodontology, College of Dentistry, University of Kentucky, Lexington, KY, USA.

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http://dx.doi.org/10.1007/978-3-030-28524-1_4DOI Listing
November 2019

Fatty Acid Metabolites Combine with Reduced β Oxidation to Activate Th17 Inflammation in Human Type 2 Diabetes.

Cell Metab 2019 Sep 1;30(3):447-461.e5. Epub 2019 Aug 1.

Department of Microbiology, Boston University School of Medicine, Boston, MA 02118 USA; Department of Pharmacology and Nutritional Sciences, University of Kentucky, Lexington, KY 40536, USA; Department of Pathology, Boston University School of Medicine, Boston, MA 02118, USA; Barnstable Brown Diabetes and Obesity Center, University of Kentucky, Lexington, KY 40536, USA. Electronic address:

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http://dx.doi.org/10.1016/j.cmet.2019.07.004DOI Listing
September 2019

Tissue Immune Cells Fuel Obesity-Associated Inflammation in Adipose Tissue and Beyond.

Front Immunol 2019 17;10:1587. Epub 2019 Jul 17.

Department of Pharmacology and Nutritional Sciences, Barnstable Brown Diabetes and Obesity Research Center, University of Kentucky, Lexington, KY, United States.

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http://dx.doi.org/10.3389/fimmu.2019.01587DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6653202PMC
July 2019

Adaptive Immunity and Metabolic Health: Harmony Becomes Dissonant in Obesity and Aging.

Compr Physiol 2017 Sep 12;7(4):1307-1337. Epub 2017 Sep 12.

Department of Microbiology, Boston University School of Medicine, Boston, Massachusetts, USA.

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http://dx.doi.org/10.1002/cphy.c160042DOI Listing
September 2017

The Immune System in Obesity: Developing Paradigms Amidst Inconvenient Truths.

Curr Diab Rep 2017 08 15;17(10):87. Epub 2017 Aug 15.

Department of Microbiology, Boston University School of Medicine, 72 East Concord Street L-516, Boston, MA, 02118, USA.

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http://dx.doi.org/10.1007/s11892-017-0917-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6826336PMC
August 2017

BET bromodomain proteins and epigenetic regulation of inflammation: implications for type 2 diabetes and breast cancer.

Cell Mol Life Sci 2017 01 4;74(2):231-243. Epub 2016 Aug 4.

Cancer Center, Boston University School of Medicine, 72 East Concord Street, Room K520, Boston, MA, 02118, USA.

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http://dx.doi.org/10.1007/s00018-016-2320-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5222701PMC
January 2017

The impact of bariatric surgery on inflammation: quenching the fire of obesity?

Curr Opin Endocrinol Diabetes Obes 2016 10;23(5):373-8

aSection of Endocrinology, Diabetes and Nutrition, Boston University School of Medicine, Boston, Massachusetts bWeis Center for Research; Geisinger Obesity Institute, Geisinger Clinic, Danville, Pennsylvania cDepartment of Microbiology; Department of Pathology; Department of Medicine; Department of Molecular and Cell Biology, Boston University School of Medicine, Boston, Massachusetts, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5067163PMC
http://dx.doi.org/10.1097/MED.0000000000000277DOI Listing
October 2016

B cells shed light on diminished vaccine responses in obesity.

Obesity (Silver Spring) 2016 Mar 5;24(3):551. Epub 2016 Feb 5.

Department of Microbiology, Boston, Massachusetts, USA.

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http://dx.doi.org/10.1002/oby.21429DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6494080PMC
March 2016

Comment on "The B Cell-Stimulatory Cytokines BLyS and APRIL Are Elevated in Human Periodontitis and Are Required for B Cell-Dependent Bone Loss in Experimental Murine Periodontitis.".

J Immunol 2015 Dec;195(11):5099

Department of Microbiology, Boston University School of Medicine, Boston, MA 02118; Department of Pathology, Boston University School of Medicine, Boston, MA 02118; Department of Medicine, Boston University School of Medicine, Boston, MA 02118; and Department of Molecular and Cell Biology, Boston University School of Medicine, Boston, MA 02118

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http://dx.doi.org/10.4049/jimmunol.1502059DOI Listing
December 2015

Lymphocyte roles in metabolic dysfunction: of men and mice.

Trends Endocrinol Metab 2015 Feb 5;26(2):91-100. Epub 2015 Jan 5.

Department of Microbiology, Boston University, Boston, MA, USA; Department of Medicine, Boston University, Boston, MA, USA. Electronic address:

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http://dx.doi.org/10.1016/j.tem.2014.12.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4315738PMC
February 2015

Immune regulators of inflammation in obesity-associated type 2 diabetes and coronary artery disease.

Curr Opin Endocrinol Diabetes Obes 2014 Oct;21(5):330-8

aDepartment of Medicine bCancer Research Center cDepartment of Microbiology, Boston University School of Medicine, Boston, Massachusetts, USA.

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http://dx.doi.org/10.1097/MED.0000000000000085DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4251956PMC
October 2014

B cells promote obesity-associated periodontitis and oral pathogen-associated inflammation.

J Leukoc Biol 2014 Aug 29;96(2):349-57. Epub 2014 Apr 29.

Department of Microbiology, Boston University School of Medicine, Boston, Massachusetts, USA;

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http://dx.doi.org/10.1189/jlb.4A0214-095RDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4101090PMC
August 2014

The double bromodomain protein Brd2 promotes B cell expansion and mitogenesis.

J Leukoc Biol 2014 Mar 6;95(3):451-60. Epub 2013 Dec 6.

1.72 East Concord St., Rm. K520, Boston, MA 02118, USA. Twitter: http://www.twitter.com/GdenisBoston.

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http://dx.doi.org/10.1189/jlb.1112588DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3923082PMC
March 2014

BET protein function is required for inflammation: Brd2 genetic disruption and BET inhibitor JQ1 impair mouse macrophage inflammatory responses.

J Immunol 2013 Apr 18;190(7):3670-8. Epub 2013 Feb 18.

Cancer Research Center, Boston University School of Medicine, Boston, MA 02118, USA.

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http://dx.doi.org/10.4049/jimmunol.1202838DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3608815PMC
April 2013

When diet and exercise are not enough, think immunomodulation.

Mol Aspects Med 2013 Feb 16;34(1):30-8. Epub 2012 Oct 16.

Boston University, Department of Microbiology, 72 East Concord Street L-516, Boston, MA 02118, United States.

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http://dx.doi.org/10.1016/j.mam.2012.10.003DOI Listing
February 2013

The Bidirectional Relationship between Metabolism and Immune Responses.

Discoveries (Craiova) 2013;1(1):e6

Boston University School of Medicine, Department of Microbiology, Boston, MA, USA.

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http://dx.doi.org/10.15190/d.2013.6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4563811PMC
January 2013

The outliers become a stampede as immunometabolism reaches a tipping point.

Immunol Rev 2012 Sep;249(1):253-75

Department of Microbiology, Boston University, Boston, MA 02118, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3419483PMC
http://dx.doi.org/10.1111/j.1600-065X.2012.01142.xDOI Listing
September 2012

Differential regulation of TLR4 expression in human B cells and monocytes.

Mol Immunol 2010 Nov-Dec;48(1-3):82-8. Epub 2010 Oct 16.

Department of Medicine, Section of Infectious Diseases, Evans Biomedical Research Center, Boston Medical Center, Boston, MA 02118, USA.

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http://dx.doi.org/10.1016/j.molimm.2010.09.008DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2993761PMC
January 2011

An emerging role for bromodomain-containing proteins in chromatin regulation and transcriptional control of adipogenesis.

FEBS Lett 2010 Aug 21;584(15):3260-8. Epub 2010 May 21.

Cancer Research Center, Department of Microbiology, Boston University School of Medicine, Boston, MA 02118, USA.

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http://dx.doi.org/10.1016/j.febslet.2010.05.030DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2914217PMC
August 2010

B cells as under-appreciated mediators of non-auto-immune inflammatory disease.

Cytokine 2010 Jun 10;50(3):234-42. Epub 2010 Apr 10.

Departments of Microbiology and Medicine, Boston University School of Medicine, 72 East Concord Street, L-516, Boston, MA 02118, USA.

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http://dx.doi.org/10.1016/j.cyto.2010.02.022DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2917985PMC
June 2010

Hyperactivated B cells in human inflammatory bowel disease.

J Leukoc Biol 2009 Oct 9;86(4):1007-16. Epub 2009 Jul 9.

Section of Infectious Disease, Department of Medicine, Boston University School of Medicine, Boston, MA 02118, USA.

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http://dx.doi.org/10.1189/jlb.0309203DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2796625PMC
October 2009

B cells from periodontal disease patients express surface Toll-like receptor 4.

J Leukoc Biol 2009 Apr 31;85(4):648-55. Epub 2008 Dec 31.

Department of Microbiology, Boston University School of Medicine, Boston, MA 02118, USA.

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http://dx.doi.org/10.1189/jlb.0708428DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2718806PMC
April 2009

Dynamic protein associations define two phases of IL-1beta transcriptional activation.

J Immunol 2008 Jul;181(1):503-12

Department of Microbiology, Boston University School of Medicine, Boston, MA 02118, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2967210PMC
http://dx.doi.org/10.4049/jimmunol.181.1.503DOI Listing
July 2008

Immunoglobulin kappa enhancers are differentially regulated at the level of chromatin structure.

Mol Immunol 2007 Jul 26;44(13):3407-15. Epub 2007 Mar 26.

Departments of Microbiology and Medicine, Boston University School of Medicine, Boston, MA 02118, USA.

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http://dx.doi.org/10.1016/j.molimm.2007.02.010DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2442924PMC
July 2007

Changes in immunoglobulin-nucleoprotein complex structure mapped by chromatin immunoprecipitation.

Mol Immunol 2006 Apr 28;43(10):1541-8. Epub 2005 Nov 28.

Department of Medicine, Boston Medical Center, Boston, MA 02118, USA.

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http://dx.doi.org/10.1016/j.molimm.2005.10.003DOI Listing
April 2006

The interleukin-1beta gene is transcribed from a poised promoter architecture in monocytes.

J Biol Chem 2006 Apr 26;281(14):9227-37. Epub 2006 Jan 26.

Department of Pathology, Boston University School of Medicine, Boston, MA 02118, USA.

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http://dx.doi.org/10.1074/jbc.M510700200DOI Listing
April 2006

The Ig kappa 3' enhancer is activated by gradients of chromatin accessibility and protein association.

J Immunol 2005 Mar;174(5):2834-42

Department of Medicine, Immunobiology Unit, Evans Memorial Department of Clinical Research, Boston Medical Center, Boston, MA 02118, USA.

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http://dx.doi.org/10.4049/jimmunol.174.5.2834DOI Listing
March 2005

PU.1 as a chromatin accessibility factor for immunoglobulin genes.

Mol Immunol 2004 Jan;40(10):723-31

Department of Medicine, Boston University School of Medicine, 650 Albany Street X-438, Boston, MA 02118, USA.

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http://dx.doi.org/10.1016/j.molimm.2003.08.007DOI Listing
January 2004

HMGA1 co-activates transcription in B cells through indirect association with DNA.

J Biol Chem 2003 Oct 7;278(43):42106-14. Epub 2003 Aug 7.

Department of Microbiology, Boston University School of Medicine, Boston, MA 02118, USA.

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http://dx.doi.org/10.1074/jbc.M308586200DOI Listing
October 2003

Dominant-negative HMGA1 blocks mu enhancer activation through a novel mechanism.

Biochem Biophys Res Commun 2002 Mar;292(2):427-33

Department of Medicine, Immunobiology Unit, Evans Memorial Department of Clinical Research, EBRC-438, Boston Medical Center, 650 Albany Street, Boston, Massachusetts 02118, USA.

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http://dx.doi.org/10.1006/bbrc.2002.6672DOI Listing
March 2002