Barbara Picconi

Barbara Picconi

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Barbara Picconi

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Differential effect of FHM2 mutation on synaptic plasticity in distinct hippocampal regions.

Cephalalgia 2019 Mar 28:333102419839967. Epub 2019 Mar 28.

1 Neurological Clinic, Department of Medicine, Hospital Santa Maria della Misericordia, University of Perugia, Perugia, Italy.

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http://dx.doi.org/10.1177/0333102419839967DOI Listing
March 2019

NMDA receptor GluN2D subunit participates to levodopa-induced dyskinesia pathophysiology.

Neurobiol Dis 2019 01 24;121:338-349. Epub 2018 Sep 24.

Dipartimento di Scienze Farmacologiche e Biomolecolari (DiSFeB), Università degli Studi di Milano - La Statale, 20133 Milano, Italy. Electronic address:

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http://dx.doi.org/10.1016/j.nbd.2018.09.021DOI Listing
January 2019

Levodopa-induced dyskinesia in Parkinson disease: Current and evolving concepts.

Ann Neurol 2018 Dec 30;84(6):797-811. Epub 2018 Nov 30.

Edmond J. Safra Program in Parkinson's Disease, Morton and Gloria Shulman Movement Disorders Clinic, Toronto Western Hospital, University Health Network, Division of Neurology, University of Toronto, Toronto, Ontario, Canada.

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http://doi.wiley.com/10.1002/ana.25364
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http://dx.doi.org/10.1002/ana.25364DOI Listing
December 2018

Synaptic plasticity and levodopa-induced dyskinesia: electrophysiological and structural abnormalities.

J Neural Transm (Vienna) 2018 Aug 28;125(8):1263-1271. Epub 2018 Feb 28.

Laboratory of Neurophysiology, IRCCS Fondazione Santa Lucia c/o CERC, via del Fosso di Fiorano 64, 00143, Rome, Italy.

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http://link.springer.com/10.1007/s00702-018-1864-6
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http://dx.doi.org/10.1007/s00702-018-1864-6DOI Listing
August 2018

Motor complications in Parkinson's disease: Striatal molecular and electrophysiological mechanisms of dyskinesias.

Mov Disord 2018 07 8;33(6):867-876. Epub 2017 Dec 8.

Fondazione Santa Lucia, IRCCS, Rome, Italy.

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http://dx.doi.org/10.1002/mds.27261DOI Listing
July 2018

Switching on the lights of dyskinesia: Perspectives and limits of the optogenetic approaches.

Mov Disord 2017 04 3;32(4):485-486. Epub 2017 Apr 3.

Fondazione Santa Lucia, IRCCS, Rome, Italy.

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http://dx.doi.org/10.1002/mds.26999DOI Listing
April 2017

Early synaptic dysfunction in Parkinson's disease: Insights from animal models.

Mov Disord 2016 06 19;31(6):802-13. Epub 2016 May 19.

Department of Systems Medicine, University of Rome "Tor Vergata", Rome, Italy.

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http://dx.doi.org/10.1002/mds.26620DOI Listing
June 2016

Hyperkinetic disorders and loss of synaptic downscaling.

Nat Neurosci 2016 06;19(7):868-75

Fondazione Santa Lucia, IRCCS, Rome, Italy.

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http://dx.doi.org/10.1038/nn.4306DOI Listing
June 2016

Memantine alters striatal plasticity inducing a shift of synaptic responses toward long-term depression.

Neuropharmacology 2016 Feb 3;101:341-50. Epub 2015 Dec 3.

Laboratorio di Neurofisiologia, Fondazione Santa Lucia, IRCCS, via del Fosso di Fiorano 64, 00143 Rome, Italy. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S00283908153013
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http://dx.doi.org/10.1016/j.neuropharm.2015.10.015DOI Listing
February 2016

Interaction between basal ganglia and limbic circuits in learning and memory processes.

Parkinsonism Relat Disord 2016 Jan 5;22 Suppl 1:S65-8. Epub 2015 Sep 5.

Fondazione Santa Lucia, IRCCS, Via del Fosso di Fiorano 64, 00143 Rome, Italy; Università degli Studi di Perugia, Dipartmento di Filosofia, Scienze Sociali, Umane e della Formazione, Perugia, Italy.

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http://dx.doi.org/10.1016/j.parkreldis.2015.09.017DOI Listing
January 2016

Levodopa-induced plasticity: a double-edged sword in Parkinson's disease?

Philos Trans R Soc Lond B Biol Sci 2015 Jul;370(1672)

Fondazione Santa Lucia, IRCCS, via del Fosso di Fiorano 64, Rome 00143, Italy.

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http://dx.doi.org/10.1098/rstb.2014.0184DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4455753PMC
July 2015

Environmental enrichment restores CA1 hippocampal LTP and reduces severity of seizures in epileptic mice.

Exp Neurol 2014 Nov 20;261:320-7. Epub 2014 May 20.

Fondazione Santa Lucia, IRCCS, Laboratory of Neurophysiology, Rome, Italy; Clinica Neurologica, Università degli Studi di Perugia, Ospedale S. Maria della Misericordia, Perugia, Italy. Electronic address:

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http://dx.doi.org/10.1016/j.expneurol.2014.05.010DOI Listing
November 2014

Direct and indirect pathways of basal ganglia: a critical reappraisal.

Nat Neurosci 2014 Aug 28;17(8):1022-30. Epub 2014 Jul 28.

Clinica Neurologica, Dipartimento di Medicina, Università degli Studi di Perugia, Ospedale Santa Maria della Misericordia, S. Andrea delle Fratte, Perugia, Italy.

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http://dx.doi.org/10.1038/nn.3743DOI Listing
August 2014

Targeting metabotropic glutamate receptors as a new strategy against levodopa-induced dyskinesia in Parkinson's disease?

Mov Disord 2014 May 3;29(6):715-9. Epub 2014 Mar 3.

Fondazione Santa Lucia, IRCCS, Rome, Italy.

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http://dx.doi.org/10.1002/mds.25851DOI Listing
May 2014

New experimental and clinical links between the hippocampus and the dopaminergic system in Parkinson's disease.

Lancet Neurol 2013 Aug;12(8):811-21

Clinica Neurologica, Università degli Studi di Perugia, Ospedale S Maria della Misericordia, Perugia, Italy.

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http://dx.doi.org/10.1016/S1474-4422(13)70118-2DOI Listing
August 2013

Targeting NR2A-containing NMDA receptors reduces L-DOPA-induced dyskinesias.

Neurobiol Aging 2012 Sep 6;33(9):2138-44. Epub 2011 Aug 6.

Dipartimento Scienze Farmacologiche, Università degli Studi di Milano, Milano, Italy.

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http://dx.doi.org/10.1016/j.neurobiolaging.2011.06.019DOI Listing
September 2012

Mechanisms underlying altered striatal synaptic plasticity in old A53T-α synuclein overexpressing mice.

Neurobiol Aging 2012 Aug 17;33(8):1792-9. Epub 2011 Jun 17.

Clinica Neurologica, Università di Perugia, Ospedale S. Maria della Misericordia, Perugia, Italy.

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http://dx.doi.org/10.1016/j.neurobiolaging.2011.05.002DOI Listing
August 2012

Θ-burst stimulation and striatal plasticity in experimental parkinsonism.

Exp Neurol 2012 Aug 1;236(2):395-8. Epub 2012 May 1.

Laboratorio di Neurofisiologia, Fondazione Santa Lucia, IRCCS, via del Fosso di Fiorano 65, 00143 Rome, Italy.

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http://dx.doi.org/10.1016/j.expneurol.2012.04.020DOI Listing
August 2012

Corticostriatal Plastic Changes in Experimental L-DOPA-Induced Dyskinesia.

Parkinsons Dis 2012 13;2012:358176. Epub 2012 May 13.

Laboratorio di Neurofisiologia, Fondazione Santa Lucia, IRCCS, Via del Fosso di Fiorano 64, 00143 Rome, Italy.

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http://dx.doi.org/10.1155/2012/358176DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3359773PMC
August 2012

Synaptic dysfunction in Parkinson's disease.

Adv Exp Med Biol 2012 ;970:553-72

Laboratorio di Neurofisiologia, Fondazione Santa Lucia IRCCS, 00143 Rome, Italy.

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http://dx.doi.org/10.1007/978-3-7091-0932-8_24DOI Listing
June 2012

Rhes-mTORC1 interaction: a new possible therapeutic target in Parkinson's disease and L-dopa-induced dyskinesia?

Mov Disord 2012 Jun;27(7):815

IRCCS Santa Lucia Foundation, Rome, Italy.

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June 2012

Prenatal stress and hippocampal BDNF expression: a fading imperative.

J Physiol 2012 Mar;590(6):1309-10

Laboratory of Neurophysiology, Fondazione Santa Lucia, IRCCS, via del Fosso di Fiorano 64, 00143, Rome, Italy.

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http://dx.doi.org/10.1113/jphysiol.2012.227777DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3382320PMC
March 2012

Striatum-hippocampus balance: from physiological behavior to interneuronal pathology.

Prog Neurobiol 2011 Jul 14;94(2):102-14. Epub 2011 Apr 14.

Fondazione Santa Lucia - IRCCS, via del Fosso di Fiorano, Rome, Italy.

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http://dx.doi.org/10.1016/j.pneurobio.2011.04.005DOI Listing
July 2011

mTOR inhibitor rapamycin suppresses striatal post-ischemic LTP.

Exp Neurol 2010 Dec 18;226(2):328-31. Epub 2010 Sep 18.

Fondazione Santa Lucia - IRCCS, via del Fosso di Fiorano, 64, 00143, Rome, Italy.

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http://dx.doi.org/10.1016/j.expneurol.2010.09.012DOI Listing
December 2010

Levodopa-induced dyskinesias in patients with Parkinson's disease: filling the bench-to-bedside gap.

Lancet Neurol 2010 Nov 27;9(11):1106-17. Epub 2010 Sep 27.

Clinica Neurologica, Università degli Studi di Perugia, Ospedale Santa Maria della Misericordia, Perugia, Italy.

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http://dx.doi.org/10.1016/S1474-4422(10)70218-0DOI Listing
November 2010

Mitochondria and the link between neuroinflammation and neurodegeneration.

J Alzheimers Dis 2010 ;20 Suppl 2:S369-79

Clinica Neurologica, Università di Perugia, Perugia, Italy.

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http://dx.doi.org/10.3233/JAD-2010-100543DOI Listing
September 2010

Impaired plasticity at specific subset of striatal synapses in the Ts65Dn mouse model of Down syndrome.

Biol Psychiatry 2010 Apr 8;67(7):666-71. Epub 2009 Oct 8.

Clinica Neurologica, Università degli Studi di Perugia, Ospedale S. Maria della Misericordia, Via S. Andrea delle Fratte, 06156 Perugia, Italy.

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http://dx.doi.org/10.1016/j.biopsych.2009.08.018DOI Listing
April 2010

Synaptic dysfunction in Parkinson's disease.

Biochem Soc Trans 2010 Apr;38(2):493-7

Laboratorio di Neurofisiologia, Fondazione Santa Lucia, I.R.C.C.S., 00143 Rome, Italy.

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http://dx.doi.org/10.1042/BST0380493DOI Listing
April 2010

Downstream mechanisms triggered by mitochondrial dysfunction in the basal ganglia: from experimental models to neurodegenerative diseases.

Biochim Biophys Acta 2010 Jan 14;1802(1):151-61. Epub 2009 Aug 14.

Institut de Biologie du Développement de Marseille-Luminy (IBDML), UMR6216 (CNRS/Université de la Méditerranée), Marseille, France.

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http://dx.doi.org/10.1016/j.bbadis.2009.08.001DOI Listing
January 2010

Electrophysiological actions of zonisamide on striatal neurons: Selective neuroprotection against complex I mitochondrial dysfunction.

Exp Neurol 2010 Jan 11;221(1):217-24. Epub 2009 Nov 11.

Clinica Neurologica, Università degli Studi di Perugia, Ospedale S. Maria della Misericordia, Perugia, Italy.

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http://dx.doi.org/10.1016/j.expneurol.2009.11.002DOI Listing
January 2010

A2A adenosine receptor antagonists protect the striatum against rotenone-induced neurotoxicity.

Exp Neurol 2009 May 29;217(1):231-4. Epub 2009 Jan 29.

Clinica Neurologia, Università di Perugia, Ospedale S. Maria della Misericordia, Perugia, Italy.

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http://dx.doi.org/10.1016/j.expneurol.2009.01.010DOI Listing
May 2009

Short-term and long-term plasticity at corticostriatal synapses: implications for learning and memory.

Behav Brain Res 2009 Apr 2;199(1):108-18. Epub 2008 Oct 2.

Clinica Neurologica, Laboratori di Neurologia Sperimentale, Universita' di Perugia, Perugia, Italy.

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http://dx.doi.org/10.1016/j.bbr.2008.09.025DOI Listing
April 2009

Neuronal networks and synaptic plasticity in Parkinson's disease: beyond motor deficits.

Parkinsonism Relat Disord 2007 ;13 Suppl 3:S259-62

Clinica Neurologica, Università degli Studi di Perugia, Ospedale S. Maria della Misericordia, Perugia, Italy.

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http://dx.doi.org/10.1016/S1353-8020(08)70013-0DOI Listing
April 2009

Molecular mechanisms underlying levodopa-induced dyskinesia.

Mov Disord 2008 ;23 Suppl 3:S570-9

Clinica Neurologica, Università degli Studi di Perugia, Ospedale S. Maria della Misericordia, Perugia, Italy.

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http://dx.doi.org/10.1002/mds.22019DOI Listing
February 2009

Decreased NR2B subunit synaptic levels cause impaired long-term potentiation but not long-term depression.

J Neurosci 2009 Jan;29(3):669-77

Department of Pharmacological Sciences and Centre of Excellence on Neurodegenerative Diseases, University of Milan, Milan, Italy.

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http://dx.doi.org/10.1523/JNEUROSCI.3921-08.2009DOI Listing
January 2009

Striatal synaptic changes in experimental parkinsonism: role of NMDA receptor trafficking in PSD.

Parkinsonism Relat Disord 2008 25;14 Suppl 2:S145-9. Epub 2008 Jun 25.

Laboratorio di Neurofisiologia, Fondazione Santa Lucia, IRCCS c/o CERC, Via del Fosso di Fiorano 64, Rome, Italy.

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http://dx.doi.org/10.1016/j.parkreldis.2008.04.019DOI Listing
December 2008

The endocannabinoid system in Parkinson's disease.

Curr Pharm Des 2008 ;14(23):2337-47

Clinica Neurologica, Ospedale S. Maria della Misericordia, Universita' di Perugia, 06156 Perugia, Italy.

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November 2008

Plasticity and repair in the post-ischemic brain.

Neuropharmacology 2008 Sep 13;55(3):353-62. Epub 2008 Feb 13.

Clinica Neurologica, Università degli Studi di Perugia, Ospedale S Maria della Misericordia, Via S Andrea delle Fratte, Perugia, Italy.

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http://dx.doi.org/10.1016/j.neuropharm.2008.01.012DOI Listing
September 2008

Acetyl-L-Carnitine selectively prevents post-ischemic LTP via a possible action on mitochondrial energy metabolism.

Neuropharmacology 2008 Aug 24;55(2):223-9. Epub 2008 May 24.

Laboratorio di Neurofisiologia, Fondazione Santa Lucia, IRCCS c/o CERC, Via del Fosso di Fiorano 64, 00143 Rome, Italy.

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http://dx.doi.org/10.1016/j.neuropharm.2008.05.015DOI Listing
August 2008

Neuroinflammation and synaptic plasticity: theoretical basis for a novel, immune-centred, therapeutic approach to neurological disorders.

Trends Pharmacol Sci 2008 Aug 9;29(8):402-12. Epub 2008 Jul 9.

Clinica Neurologica, Università degli Studi di Perugia, Perugia, Italy.

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http://dx.doi.org/10.1016/j.tips.2008.06.005DOI Listing
August 2008

l-DOPA dosage is critically involved in dyskinesia via loss of synaptic depotentiation.

Neurobiol Dis 2008 Feb 11;29(2):327-35. Epub 2007 Oct 11.

Laboratorio di Neurofisiologia, Fondazione Santa Lucia, IRCCS c/o CERC, Rome, Italy.

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http://dx.doi.org/10.1016/j.nbd.2007.10.001DOI Listing
February 2008

Interaction of A2A adenosine and D2 dopamine receptors modulates corticostriatal glutamatergic transmission.

Neuropharmacology 2007 Nov 16;53(6):783-9. Epub 2007 Aug 16.

Clinica Neurologia, Università di Perugia, Ospedale S. Maria della Misericordia, 06156 Perugia, Italy.

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http://dx.doi.org/10.1016/j.neuropharm.2007.08.006DOI Listing
November 2007

Synaptic plasticity during recovery from permanent occlusion of the middle cerebral artery.

Neurobiol Dis 2007 Jul 5;27(1):44-53. Epub 2007 Apr 5.

Clinica Neurologica, Dipartimento di Neuroscienze, Università Tor Vergata, Rome, Italy.

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http://dx.doi.org/10.1016/j.nbd.2007.03.012DOI Listing
July 2007

Dopamine-mediated regulation of corticostriatal synaptic plasticity.

Trends Neurosci 2007 May 23;30(5):211-9. Epub 2007 Mar 23.

Clinica Neurologica, Università di Perugia, Ospedale S. Maria della Misericordia, Via S. Andrea delle Fratte, 06156, Perugia, Italy.

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http://dx.doi.org/10.1016/j.tins.2007.03.001DOI Listing
May 2007

Plastic abnormalities in experimental Huntington's disease.

Curr Opin Pharmacol 2007 Feb 30;7(1):106-11. Epub 2006 Oct 30.

Clinica Neurologica, Università degli Studi di Perugia, Ospedale S. Maria della Misericordia, Via S Andrea delle Fratte, 06156, Perugia, Italy; IRCCS Fondazione Santa Lucia, Rome, Italy.

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http://dx.doi.org/10.1016/j.coph.2006.08.010DOI Listing
February 2007

NR2B-containing NMDA receptors promote the neurotoxic effects of 3-nitropropionic acid but not of rotenone in the striatum.

Exp Neurol 2006 Dec 17;202(2):470-9. Epub 2006 Aug 17.

Clinica Neurologica, Dipartimento di Neuroscienze, Università Tor Vergata, 00133 Rome, Italy.

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http://dx.doi.org/10.1016/j.expneurol.2006.07.009DOI Listing
December 2006

Deficits of glutamate transmission in the striatum of toxic and genetic models of Huntington's disease.

Neurosci Lett 2006 Dec 27;410(1):6-10. Epub 2006 Oct 27.

Clinica Neurologica, Dipartimento di Neuroscienze, Università Tor Vergata, Via Montpellier 1, 00133 Rome, Italy.

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http://dx.doi.org/10.1016/j.neulet.2006.09.056DOI Listing
December 2006

A convergent model for cognitive dysfunctions in Parkinson's disease: the critical dopamine-acetylcholine synaptic balance.

Lancet Neurol 2006 Nov;5(11):974-83

Clinica Neurologica, Dip. Specialità Medico-Chirurgiche, Università di Perugia, Italy.

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http://dx.doi.org/10.1016/S1474-4422(06)70600-7DOI Listing
November 2006

Pathways of neurodegeneration and experimental models of basal ganglia disorders: downstream effects of mitochondrial inhibition.

Eur J Pharmacol 2006 Sep 16;545(1):65-72. Epub 2006 Jun 16.

Clinica Neurologica, Università degli Studi di Perugia, Ospedale Silvestrini, Perugia, Italy.

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http://dx.doi.org/10.1016/j.ejphar.2006.06.024DOI Listing
September 2006

Acetyl-L-carnitine protects striatal neurons against in vitro ischemia: the role of endogenous acetylcholine.

Neuropharmacology 2006 Jun 24;50(8):917-23. Epub 2006 Feb 24.

Laboratorio di Neurofisiologia, Fondazione Santa Lucia, IRCCS, Rome, Italy.

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http://dx.doi.org/10.1016/j.neuropharm.2006.01.002DOI Listing
June 2006

L-DOPA treatment of parkinsonian rats changes the expression of Src, Lyn and PKC kinases.

Neurosci Lett 2006 May 9;398(3):211-4. Epub 2006 Mar 9.

Dipartimento di Medicina Sperimentale e Patologia, Università La Sapienza, viale Regina Elena 324, 00161 Rome, Italy.

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http://dx.doi.org/10.1016/j.neulet.2005.12.077DOI Listing
May 2006

Multiple mechanisms underlying the neuroprotective effects of antiepileptic drugs against in vitro ischemia.

Stroke 2006 May 30;37(5):1319-26. Epub 2006 Mar 30.

Clinica Neurologica, Università di Perugia, Ospedale Silvestrini, S. Andrea delle Fratte, Perugia, Italy.

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http://dx.doi.org/10.1161/01.STR.0000217303.22856.38DOI Listing
May 2006

Plastic and behavioral abnormalities in experimental Huntington's disease: a crucial role for cholinergic interneurons.

Neurobiol Dis 2006 Apr 2;22(1):143-52. Epub 2005 Dec 2.

Laboratorio di Neurofisiologia, Fondazione Santa Lucia, IRCCS, Via del Fosso di Fiorano 65, 00143 Rome, Italy.

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http://dx.doi.org/10.1016/j.nbd.2005.10.009DOI Listing
April 2006

A critical interaction between NR2B and MAGUK in L-DOPA induced dyskinesia.

J Neurosci 2006 Mar;26(11):2914-22

Center of Excellence on Neurodegenerative Diseases, Department of Pharmacological Sciences, University of Milan, 20133 Milan, Italy.

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http://dx.doi.org/10.1523/JNEUROSCI.5326-05.2006DOI Listing
March 2006

Pathological synaptic plasticity in the striatum: implications for Parkinson's disease.

Neurotoxicology 2005 Oct 31;26(5):779-83. Epub 2005 May 31.

Clinica Neurologica, Dipartimento di Neuroscienze, Università di Roma Tor Vergata and Fondazione Santa Lucia, I.R.C.C.S., Via di Tor Vergata 135, Roma, Italy.

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http://dx.doi.org/10.1016/j.neuro.2005.02.002DOI Listing
October 2005

Chronic haloperidol promotes corticostriatal long-term potentiation by targeting dopamine D2L receptors.

J Neurosci 2004 Sep;24(38):8214-22

Clinica Neurologica, Dipartimento di Neuroscienze, Università Tor Vergata, 00133 Rome, Italy.

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http://dx.doi.org/10.1523/JNEUROSCI.1274-04.2004DOI Listing
September 2004

Therapeutic doses of L-dopa reverse hypersensitivity of corticostriatal D2-dopamine receptors and glutamatergic overactivity in experimental parkinsonism.

Brain 2004 Jul 20;127(Pt 7):1661-9. Epub 2004 May 20.

Dipartimento di Neuroscienze, Clinica Neurologica, Universita di Roma 'Tor Vergata', Rome, Italy.

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http://dx.doi.org/10.1093/brain/awh190DOI Listing
July 2004

Abnormal Ca2+-calmodulin-dependent protein kinase II function mediates synaptic and motor deficits in experimental parkinsonism.

J Neurosci 2004 Jun;24(23):5283-91

Clinica Neurologica, Dipartimento di Neuroscienze, Universita di Roma Tor Vergata, 00133 Rome, Italy.

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http://dx.doi.org/10.1523/JNEUROSCI.1224-04.2004DOI Listing
June 2004

Loss of bidirectional striatal synaptic plasticity in L-DOPA-induced dyskinesia.

Nat Neurosci 2003 May;6(5):501-6

Clinica Neurologica, Dipartimento di Neuroscienze, Università di Roma Tor Vergata, Via Montpellier 1, 00133 Rome, Italy.

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http://dx.doi.org/10.1038/nn1040DOI Listing
May 2003

Levodopa treatment reverses endocannabinoid system abnormalities in experimental parkinsonism.

J Neurochem 2003 May;85(4):1018-25

Dipartimento di Medicina Sperimentale e Scienze Biochimiche and Dipartimento di Neuroscienze, Università degli Studi di Roma Tor Vergata, Via Montpellier 1, 00133 Rome, Italy.

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May 2003

Striatal metabotropic glutamate receptor function following experimental parkinsonism and chronic levodopa treatment.

Brain 2002 Dec;125(Pt 12):2635-45

Clinica Neurologica, Dipartimento di Neuroscienze, Università di Roma Tor Vergata, I.R.C.C.S. Fondazione Santa Lucia, Italy.

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http://dx.doi.org/10.1093/brain/awf269DOI Listing
December 2002

Experimental parkinsonism modulates multiple genes involved in the transduction of dopaminergic signals in the striatum.

Neurobiol Dis 2002 Aug;10(3):387-95

Dipartimento di Medicina Sperimentale e Patologia, Università La Sapienza, Rome, Italy.

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August 2002