Publications by authors named "Barbara Klink"

69Publications

AN1-type zinc finger protein 3 (ZFAND3) is a transcriptional regulator that drives Glioblastoma invasion.

Authors:
Anne Schuster Eliane Klein Virginie Neirinckx Arnon Møldrup Knudsen Carina Fabian Ann-Christin Hau Monika Dieterle Anais Oudin Petr V Nazarov Anna Golebiewska Arnaud Muller Daniel Perez-Hernandez Sophie Rodius Gunnar Dittmar Rolf Bjerkvig Christel Herold-Mende Barbara Klink Bjarne Winther Kristensen Simone P Niclou

Nat Commun 2020 12 11;11(1):6366. Epub 2020 Dec 11.

NORLUX Neuro-Oncology Laboratory, Department of Oncology, Luxembourg Institute of Health, Luxembourg, Luxembourg.

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December 2020

Patient-derived organoids and orthotopic xenografts of primary and recurrent gliomas represent relevant patient avatars for precision oncology.

Authors:
Anna Golebiewska Ann-Christin Hau Anaïs Oudin Daniel Stieber Yahaya A Yabo Virginie Baus Vanessa Barthelemy Eliane Klein Sébastien Bougnaud Olivier Keunen May Wantz Alessandro Michelucci Virginie Neirinckx Arnaud Muller Tony Kaoma Petr V Nazarov Francisco Azuaje Alfonso De Falco Ben Flies Lorraine Richart Suresh Poovathingal Thais Arns Kamil Grzyb Andreas Mock Christel Herold-Mende Anne Steino Dennis Brown Patrick May Hrvoje Miletic Tathiane M Malta Houtan Noushmehr Yong-Jun Kwon Winnie Jahn Barbara Klink Georgette Tanner Lucy F Stead Michel Mittelbronn Alexander Skupin Frank Hertel Rolf Bjerkvig Simone P Niclou

Acta Neuropathol 2020 12 3;140(6):919-949. Epub 2020 Oct 3.

NORLUX Neuro-Oncology Laboratory, Department of Oncology, Luxembourg Institute of Health, 84, Val Fleuri, 1526, Luxembourg, Luxembourg.

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December 2020

A mathematical model of the metastatic bottleneck predicts patient outcome and response to cancer treatment.

Authors:
Ewa Szczurek Tyll Krüger Barbara Klink Niko Beerenwinkel

PLoS Comput Biol 2020 10 2;16(10):e1008056. Epub 2020 Oct 2.

Department of Biosystems Science and Engineering, ETH Zurich, Basel, Switzerland.

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October 2020

Correction: Diagnostic value of partial exome sequencing in developmental disorders.

Authors:
Laura Gieldon Luisa Mackenroth Anne-Karin Kahlert Johannes R Lemke Joseph Porrmann Jens Schallner Maja von der Hagen Susanne Markus Sabine Weidensee Barbara Novotna Charlotte Soerensen Barbara Klink Johannes Wagner Andreas Tzschach Arne Jahn Franziska Kuhlee Karl Hackmann Evelin Schrock Nataliya Di Donato Andreas Rump

PLoS One 2020 24;15(9):e0239959. Epub 2020 Sep 24.

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September 2020

Molecular Characterization of Astrocytoma Progression Towards Secondary Glioblastomas Utilizing Patient-Matched Tumor Pairs.

Authors:
Michael Seifert Gabriele Schackert Achim Temme Evelin Schröck Andreas Deutsch Barbara Klink

Cancers (Basel) 2020 Jun 26;12(6). Epub 2020 Jun 26.

National Center for Tumor Diseases (NCT), Partner Site Dresden, D-01307 Dresden, Germany.

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June 2020

Metabolomics, machine learning and immunohistochemistry to predict succinate dehydrogenase mutational status in phaeochromocytomas and paragangliomas.

Authors:
Paal W Wallace Catleen Conrad Sascha Brückmann Ying Pang Eduardo Caleiras Masanori Murakami Esther Korpershoek Zhengping Zhuang Elena Rapizzi Matthias Kroiss Volker Gudziol Henri Jlm Timmers Massimo Mannelli Jens Pietzsch Felix Beuschlein Karel Pacak Mercedes Robledo Barbara Klink Mirko Peitzsch Anthony J Gill Arthur S Tischler Ronald R de Krijger Thomas Papathomas Daniela Aust Graeme Eisenhofer Susan Richter

J Pathol 2020 08 1;251(4):378-387. Epub 2020 Jul 1.

Institute of Clinical Chemistry and Laboratory Medicine, University Hospital Carl Gustav Carus, Medical Faculty Carl Gustav Carus, Technische Universität Dresden, Dresden, Germany.

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August 2020

The landscape of chromothripsis across adult cancer types.

Authors:
Natalia Voronina John K L Wong Daniel Hübschmann Mario Hlevnjak Sebastian Uhrig Christoph E Heilig Peter Horak Simon Kreutzfeldt Andreas Mock Albrecht Stenzinger Barbara Hutter Martina Fröhlich Benedikt Brors Arne Jahn Barbara Klink Laura Gieldon Lina Sieverling Lars Feuerbach Priya Chudasama Katja Beck Matthias Kroiss Christoph Heining Lino Möhrmann Andrea Fischer Evelin Schröck Hanno Glimm Marc Zapatka Peter Lichter Stefan Fröhling Aurélie Ernst

Nat Commun 2020 05 8;11(1):2320. Epub 2020 May 8.

Group Genome Instability in Tumors, DKFZ, Heidelberg, Germany.

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May 2020

Mutant IDH1 Differently Affects Redox State and Metabolism in Glial Cells of Normal and Tumor Origin.

Authors:
Julia Biedermann Matthias Preussler Marina Conde Mirko Peitzsch Susan Richter Ralf Wiedemuth Khalil Abou-El-Ardat Alexander Krüger Matthias Meinhardt Gabriele Schackert William P Leenders Christel Herold-Mende Simone P Niclou Rolf Bjerkvig Graeme Eisenhofer Achim Temme Michael Seifert Leoni A Kunz-Schughart Evelin Schröck Barbara Klink

Cancers (Basel) 2019 Dec 16;11(12). Epub 2019 Dec 16.

Institute for Clinical Genetics, Faculty of Medicine Carl Gustav Carus, Technische Universität Dresden, Fetscherstraße 74, 01307 Dresden, Germany.

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December 2019

Network-based analysis of prostate cancer cell lines reveals novel marker gene candidates associated with radioresistance and patient relapse.

Authors:
Michael Seifert Claudia Peitzsch Ielizaveta Gorodetska Caroline Börner Barbara Klink Anna Dubrovska

PLoS Comput Biol 2019 11 4;15(11):e1007460. Epub 2019 Nov 4.

OncoRay - National Center for Radiation Research in Oncology, Faculty of Medicine and University Hospital Carl Gustav Carus, Technische Universität Dresden, Helmholtz-Zentrum Dresden-Rossendorf (HZDR), Dresden, Germany.

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November 2019

Synergistic Highly Potent Targeted Drug Combinations in Different Pheochromocytoma Models Including Human Tumor Cultures.

Authors:
Maria Fankhauser Nicole Bechmann Michael Lauseker Judith Goncalves Judith Favier Barbara Klink Doreen William Laura Gieldon Julian Maurer Gerald Spöttl Petra Rank Thomas Knösel Michael Orth Christian G Ziegler Elke Tatjana Aristizabal Prada German Rubinstein Martin Fassnacht Christine Spitzweg Ashley B Grossman Karel Pacak Felix Beuschlein Stefan R Bornstein Graeme Eisenhofer Christoph J Auernhammer Martin Reincke Svenja Nölting

Endocrinology 2019 11;160(11):2600-2617

Medizinische Klinik und Poliklinik IV, Klinikum der Universität, LMU München, Munich, Germany.

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November 2019

Deep sequencing of a recurrent oligodendroglioma and the derived xenografts reveals new insights into the evolution of human oligodendroglioma and candidate driver genes.

Authors:
Nadin D Exner Jaime Alberto Campos Valenzuela Khalil Abou-El-Ardat Hrvoje Miletic Peter C Huszthy Petra M Radehaus Evelin Schröck Rolf Bjerkvig Lars Kaderali Barbara Klink Janice M Nigro

Oncotarget 2019 Jun 4;10(38):3641-3653. Epub 2019 Jun 4.

Department of Biomedicine, University of Bergen, Bergen, Norway.

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June 2019

Optimizing Genetic Workup in Pheochromocytoma and Paraganglioma by Integrating Diagnostic and Research Approaches.

Authors:
Laura Gieldon Doreen William Karl Hackmann Winnie Jahn Arne Jahn Johannes Wagner Andreas Rump Nicole Bechmann Svenja Nölting Thomas Knösel Volker Gudziol Georgiana Constantinescu Jimmy Masjkur Felix Beuschlein Henri Jlm Timmers Letizia Canu Karel Pacak Mercedes Robledo Daniela Aust Evelin Schröck Graeme Eisenhofer Susan Richter Barbara Klink

Cancers (Basel) 2019 Jun 11;11(6). Epub 2019 Jun 11.

Institute for Clinical Genetics, Medical Faculty Carl Gustav Carus, Technische Universität Dresden, 01307 Dresden, Germany.

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June 2019

Controlling distinct signaling states in cultured cancer cells provides a new platform for drug discovery.

Authors:
Steven W Poser Oliver Otto Carina Arps-Forker Yan Ge Maik Herbig Cordula Andree Konrad Gruetzmann Melissa F Adasme Szymon Stodolak Polyxeni Nikolakopoulou Deric M Park Alan Mcintyre Mathias Lesche Andreas Dahl Petra Lennig Stefan R Bornstein Evelin Schroeck Barbara Klink Ronen R Leker Marc Bickle George P Chrousos Michael Schroeder Carlo Vittorio Cannistraci Jochen Guck Andreas Androutsellis-Theotokis

FASEB J 2019 08 30;33(8):9235-9249. Epub 2019 May 30.

Department of Internal Medicine III, Technische Universität Dresden, Dresden, Germany.

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August 2019

Targeted capture-based NGS is superior to multiplex PCR-based NGS for hereditary BRCA1 and BRCA2 gene analysis in FFPE tumor samples.

Authors:
Falk Zakrzewski Laura Gieldon Andreas Rump Michael Seifert Konrad Grützmann Alexander Krüger Sina Loos Silke Zeugner Karl Hackmann Joseph Porrmann Johannes Wagner Karin Kast Pauline Wimberger Gustavo Baretton Evelin Schröck Daniela Aust Barbara Klink

BMC Cancer 2019 Apr 27;19(1):396. Epub 2019 Apr 27.

Core Unit for Molecular Tumor Diagnostics (CMTD), National Center for Tumor Diseases (NCT), Schubertstraße 15, 01307, Dresden, Germany.

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April 2019

Defective homologous recombination DNA repair as therapeutic target in advanced chordoma.

Authors:
Stefan Gröschel Daniel Hübschmann Francesco Raimondi Peter Horak Gregor Warsow Martina Fröhlich Barbara Klink Laura Gieldon Barbara Hutter Kortine Kleinheinz David Bonekamp Oliver Marschal Priya Chudasama Jagoda Mika Marie Groth Sebastian Uhrig Stephen Krämer Christoph Heining Christoph E Heilig Daniela Richter Eva Reisinger Katrin Pfütze Roland Eils Stephan Wolf Christof von Kalle Christian Brandts Claudia Scholl Wilko Weichert Stephan Richter Sebastian Bauer Roland Penzel Evelin Schröck Albrecht Stenzinger Richard F Schlenk Benedikt Brors Robert B Russell Hanno Glimm Matthias Schlesner Stefan Fröhling

Nat Commun 2019 04 9;10(1):1635. Epub 2019 Apr 9.

German Cancer Consortium (DKTK), 69120, Heidelberg, Germany.

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April 2019

Response to olaparib in a germline mutated prostate cancer and genetic events associated with resistance.

Authors:
Peter Horak Joachim Weischenfeldt Gunhild von Amsberg Burkhard Beyer Andreas Schütte Sebastian Uhrig Laura Gieldon Barbara Klink Lars Feuerbach Daniel Hübschmann Simon Kreutzfeldt Christoph Heining Sebastian Maier Barbara Hutter Roland Penzel Matthias Schlesner Roland Eils Guido Sauter Albrecht Stenzinger Benedikt Brors Evelin Schröck Hanno Glimm Stefan Fröhling Thorsten Schlomm

Cold Spring Harb Mol Case Stud 2019 04 1;5(2). Epub 2019 Apr 1.

Department of Urology, Charité-Universitätsmedizin Berlin, 10117 Berlin, Germany.

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April 2019

Patterns of Tumor Progression Predict Small and Tissue-Specific Tumor-Originating Niches.

Authors:
Thomas Buder Andreas Deutsch Barbara Klink Anja Voss-Böhme

Front Oncol 2018 10;8:668. Epub 2019 Jan 10.

Center for Information Services and High Performance Computing, Technische Universität Dresden, Dresden, Germany.

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January 2019

The CD98 Heavy Chain Is a Marker and Regulator of Head and Neck Squamous Cell Carcinoma Radiosensitivity.

Authors:
David Digomann Ina Kurth Anna Tyutyunnykova Oleg Chen Steffen Löck Ielizaveta Gorodetska Claudia Peitzsch Ira-Ida Skvortsova Giulia Negro Bertram Aschenbrenner Graeme Eisenhofer Susan Richter Stephan Heiden Joseph Porrmann Barbara Klink Christian Schwager Adam A Dowle Linda Hein Leoni A Kunz-Schughart Amir Abdollahi Fabian Lohaus Mechthild Krause Michael Baumann Annett Linge Anna Dubrovska

Clin Cancer Res 2019 05 22;25(10):3152-3163. Epub 2019 Jan 22.

OncoRay-National Center for Radiation Research in Oncology, Faculty of Medicine and University Hospital Carl Gustav Carus, Technische Universität Dresden, Helmholtz-Zentrum Dresden-Rossendorf, Dresden, Germany.

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May 2019

Author Correction: Variants in exons 5 and 6 of ACTB cause syndromic thrombocytopenia.

Authors:
Sharissa L Latham Nadja Ehmke Patrick Y A Reinke Manuel H Taft Dorothee Eicke Theresia Reindl Werner Stenzel Michael J Lyons Michael J Friez Jennifer A Lee Ramona Hecker Michael C Frühwald Kerstin Becker Teresa M Neuhann Denise Horn Evelin Schrock Indra Niehaus Katharina Sarnow Konrad Grützmann Luzie Gawehn Barbara Klink Andreas Rump Christine Chaponnier Constanca Figueiredo Ralf Knöfler Dietmar J Manstein Nataliya Di Donato

Nat Commun 2018 11 19;9(1):4930. Epub 2018 Nov 19.

Institute for Clinical Genetics, TU Dresden, 01307, Dresden, Germany.

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November 2018

Variants in exons 5 and 6 of ACTB cause syndromic thrombocytopenia.

Authors:
Sharissa L Latham Nadja Ehmke Patrick Y A Reinke Manuel H Taft Dorothee Eicke Theresia Reindl Werner Stenzel Michael J Lyons Michael J Friez Jennifer A Lee Ramona Hecker Michael C Frühwald Kerstin Becker Teresa M Neuhann Denise Horn Evelin Schrock Indra Niehaus Katharina Sarnow Konrad Grützmann Luzie Gawehn Barbara Klink Andreas Rump Christine Chaponnier Constanca Figueiredo Ralf Knöfler Dietmar J Manstein Nataliya Di Donato

Nat Commun 2018 10 12;9(1):4250. Epub 2018 Oct 12.

Institute for Clinical Genetics, TU Dresden, Dresden, 01307, Germany.

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October 2018