Barbara J Graves

Barbara J Graves

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Barbara J Graves

Barbara J Graves

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The Biophysical Basis for Phosphorylation-Enhanced DNA-Binding Autoinhibition of the ETS1 Transcription Factor.

J Mol Biol 2019 Feb 28;431(3):593-614. Epub 2018 Dec 28.

Genome Sciences and Technology Program, University of British Columbia, Vancouver, BC, Canada V6T 1Z3; Department of Biochemistry and Molecular Biology, University of British Columbia, Vancouver, BC, Canada V6T 1Z3; Department of Chemistry, University of British Columbia, Vancouver, BC, Canada V6T 1Z1; Michael Smith Laboratories, University of British Columbia, Vancouver, BC, Canada V6T 1Z4. Electronic address:

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http://dx.doi.org/10.1016/j.jmb.2018.12.011DOI Listing
February 2019

Development of High-Throughput Screening Assays for Inhibitors of ETS Transcription Factors.

SLAS Discov 2019 01 11;24(1):77-85. Epub 2018 Sep 11.

1 Department of Oncological Sciences, School of Medicine, Huntsman Cancer Institute, University of Utah, Salt Lake City, UT, USA.

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http://dx.doi.org/10.1177/2472555218798571DOI Listing
January 2019

ETV4 and AP1 Transcription Factors Form Multivalent Interactions with three Sites on the MED25 Activator-Interacting Domain.

J Mol Biol 2017 10 17;429(20):2975-2995. Epub 2017 Jul 17.

Department of Oncological Sciences, University of Utah School of Medicine, Salt Lake City, UT, 84112-5500, USA; Huntsman Cancer Institute, University of Utah, Salt Lake City, UT, 84112-5500, USA; Howard Hughes Medical Institute, Chevy Chase, MD, 20815-6789, USA. Electronic address:

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http://dx.doi.org/10.1016/j.jmb.2017.06.024DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5632138PMC
October 2017

Conformational Dynamics and the Binding of Specific and Nonspecific DNA by the Autoinhibited Transcription Factor Ets-1.

Biochemistry 2016 07 15;55(29):4105-18. Epub 2016 Jul 15.

Department of Biochemistry and Molecular Biology, Department of Chemistry, and Michael Smith Laboratories, University of British Columbia , Vancouver, British Columbia V6T 1Z3, Canada.

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http://dx.doi.org/10.1021/acs.biochem.6b00460DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5568661PMC
July 2016

Autoinhibition of ETV6 DNA Binding Is Established by the Stability of Its Inhibitory Helix.

J Mol Biol 2016 Apr 23;428(8):1515-30. Epub 2016 Feb 23.

Department of Biochemistry and Molecular Biology, Department of Chemistry, and Michael Smith Laboratories, University of British Columbia, Vancouver, BC V6T 1Z3, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.jmb.2016.02.020DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5575937PMC
April 2016

Synergy of aromatic residues and phosphoserines within the intrinsically disordered DNA-binding inhibitory elements of the Ets-1 transcription factor.

Proc Natl Acad Sci U S A 2014 Jul 14;111(30):11019-24. Epub 2014 Jul 14.

Department of Biochemistry and Molecular Biology, Department of Chemistry, and Michael Smith Laboratories, University of British Columbia, Vancouver, BC, Canada V6T 1Z3;

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http://dx.doi.org/10.1073/pnas.1401891111DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4121781PMC
July 2014

Dual views of SRF: a genomic exposure.

Genes Dev 2014 May;28(9):926-8

Department of Oncological Sciences, University of Utah School of Medicine, Salt Lake City, Utah 84112, USA;

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http://dx.doi.org/10.1101/gad.242420.114DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4018491PMC
May 2014

Steric mechanism of auto-inhibitory regulation of specific and non-specific DNA binding by the ETS transcriptional repressor ETV6.

J Mol Biol 2014 Apr 12;426(7):1390-406. Epub 2013 Dec 12.

Department of Biochemistry and Molecular Biology, Department of Chemistry, and Michael Smith Laboratories, University of British Columbia, Vancouver, BC, Canada V6T 1Z3. Electronic address:

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http://dx.doi.org/10.1016/j.jmb.2013.11.031DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4278593PMC
April 2014

Autoinhibition of ETV6 (TEL) DNA binding: appended helices sterically block the ETS domain.

J Mol Biol 2012 Aug 12;421(1):67-84. Epub 2012 May 12.

Department of Biochemistry and Molecular Biology, University of British Columbia, Vancouver, BC, Canada V6T 1Z3.

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http://dx.doi.org/10.1016/j.jmb.2012.05.010DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3392548PMC
August 2012

Genomic and biochemical insights into the specificity of ETS transcription factors.

Annu Rev Biochem 2011 ;80:437-71

Medical Sciences, Indiana University School of Medicine, Bloomington, Indiana 47405, USA.

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http://dx.doi.org/10.1146/annurev.biochem.79.081507.103945DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5568663PMC
October 2011

Oncogenic ETS proteins mimic activated RAS/MAPK signaling in prostate cells.

Genes Dev 2011 Oct;25(20):2147-57

Medical Sciences, Indiana University School of Medicine, Bloomington, USA.

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http://dx.doi.org/10.1101/gad.17546311DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3205585PMC
October 2011

ETS-4 is a transcriptional regulator of life span in Caenorhabditis elegans.

PLoS Genet 2010 Sep 16;6(9):e1001125. Epub 2010 Sep 16.

Huntsman Cancer Institute, Department of Oncological Sciences, University of Utah, Salt Lake City, Utah, USA.

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http://dx.doi.org/10.1371/journal.pgen.1001125DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2940738PMC
September 2010

DNA binding by the ETS protein TEL (ETV6) is regulated by autoinhibition and self-association.

J Biol Chem 2010 Jun 16;285(24):18496-504. Epub 2010 Apr 16.

Department of Oncological Sciences, University of Utah School of Medicine, Huntsman Cancer Institute, University of Utah, Salt Lake City, Utah 84112-5550, USA.

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http://otter.biochem.ubc.ca/publications/Green_JBC_Tel_2010.
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http://www.jbc.org/content/285/24/18496.full.pdf
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http://www.jbc.org/lookup/doi/10.1074/jbc.M109.096958
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http://dx.doi.org/10.1074/jbc.M109.096958DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2881775PMC
June 2010

Ras signaling requires dynamic properties of Ets1 for phosphorylation-enhanced binding to coactivator CBP.

Proc Natl Acad Sci U S A 2010 Jun 13;107(22):10026-31. Epub 2010 May 13.

Department of Oncological Sciences, University of Utah School of Medicine, Huntsman Cancer Institute, University of Utah, Salt Lake City, UT, 84112, USA.

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http://dx.doi.org/10.1073/pnas.0915137107DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2890480PMC
June 2010

Human RNA polymerase III transcriptomes and relationships to Pol II promoter chromatin and enhancer-binding factors.

Nat Struct Mol Biol 2010 May 25;17(5):620-8. Epub 2010 Apr 25.

Department of Oncological Sciences, Huntsman Cancer Institute, University of Utah School of Medicine, Salt Lake City, Utah, USA.

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http://dx.doi.org/10.1038/nsmb.1801DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2945309PMC
May 2010

The GNUMAP algorithm: unbiased probabilistic mapping of oligonucleotides from next-generation sequencing.

Bioinformatics 2010 Jan 27;26(1):38-45. Epub 2009 Oct 27.

Department of Computer Science, Department of Statistics, Brigham Young University, Provo, UT 84602, USA.

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http://dx.doi.org/10.1093/bioinformatics/btp614DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6276904PMC
January 2010

DNA specificity determinants associate with distinct transcription factor functions.

PLoS Genet 2009 Dec 18;5(12):e1000778. Epub 2009 Dec 18.

Huntsman Cancer Institute, Department of Oncological Sciences, University of Utah, Salt Lake City, Utah, United States of America.

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http://dx.doi.org/10.1371/journal.pgen.1000778DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2787013PMC
December 2009

Detection and assignment of phosphoserine and phosphothreonine residues by (13)C- (31)P spin-echo difference NMR spectroscopy.

J Biomol NMR 2009 Jan 12;43(1):31-7. Epub 2008 Nov 12.

Department of Biochemistry, University of British Columbia, Vancouver, BC, Canada.

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http://dx.doi.org/10.1007/s10858-008-9287-6DOI Listing
January 2009

The affinity of Ets-1 for DNA is modulated by phosphorylation through transient interactions of an unstructured region.

J Mol Biol 2008 Oct 29;382(4):1014-30. Epub 2008 Jul 29.

Department of Biochemistry and Molecular Biology, University of British Columbia, Vancouver, BC, Canada V6T 1Z3.

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http://dx.doi.org/10.1016/j.jmb.2008.07.064DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4808631PMC
October 2008

Microsatellites as EWS/FLI response elements in Ewing's sarcoma.

Proc Natl Acad Sci U S A 2008 Jul 14;105(29):10149-54. Epub 2008 Jul 14.

Department of Oncological Sciences, Huntsman Cancer Institute, University of Utah, Salt Lake City, UT 84112, USA.

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http://dx.doi.org/10.1073/pnas.0801073105DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2481306PMC
July 2008

Role of Ets-1 phosphorylation in the effector function of Th cells.

Eur J Immunol 2008 Jun;38(6):1700-5

Division of Rheumatology, Immunology, and Allergy, Department of Medicine, Brigham and Women's Hospital, Boston, MA 02115, USA.

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http://dx.doi.org/10.1002/eji.200738112DOI Listing
June 2008

Identification and structural characterization of a CBP/p300-binding domain from the ETS family transcription factor GABP alpha.

J Mol Biol 2008 Mar 30;377(3):636-46. Epub 2008 Jan 30.

Department of Biochemistry and Molecular Biology, University of British Columbia, Vancouver, BC, Canada.

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http://dx.doi.org/10.1016/j.jmb.2008.01.054DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2486348PMC
March 2008

Genome-wide analyses reveal properties of redundant and specific promoter occupancy within the ETS gene family.

Genes Dev 2007 Aug 24;21(15):1882-94. Epub 2007 Jul 24.

Department of Oncological Sciences, Huntsman Cancer Institute, University of Utah, Salt Lake City, Utah 84112, USA.

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http://www.genesdev.org/cgi/doi/10.1101/gad.1561707
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http://dx.doi.org/10.1101/gad.1561707DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1935027PMC
August 2007

Transcription saga tells developmental stories.

Development 2006 Nov;133(22):4393-7

Department of Oncological Sciences, Huntsman Cancer Institute, University of Utah, Salt Lake City, UT 84112, USA.

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http://dx.doi.org/10.1242/dev.02639DOI Listing
November 2006

Beads-on-a-string, characterization of ETS-1 sumoylated within its flexible N-terminal sequence.

J Biol Chem 2006 Feb 29;281(7):4164-72. Epub 2005 Nov 29.

Department of Biochemistry and Molecular Biology, University of British Columbia, Vancouver, Canada.

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http://dx.doi.org/10.1074/jbc.M510488200DOI Listing
February 2006

Variable control of Ets-1 DNA binding by multiple phosphates in an unstructured region.

Science 2005 Jul;309(5731):142-5

Huntsman Cancer Institute, Department of Oncological Sciences, University of Utah, Salt Lake City, UT 84112-5550, USA.

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http://dx.doi.org/10.1126/science.1111915DOI Listing
July 2005

The structural and dynamic basis of Ets-1 DNA binding autoinhibition.

J Biol Chem 2005 Feb 9;280(8):7088-99. Epub 2004 Dec 9.

Department of Biochemistry and Molecular Biology, University of British Columbia, Vancouver, British Columbia V6T 1Z3, Canada.

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http://www.jbc.org/lookup/doi/10.1074/jbc.M410722200
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http://dx.doi.org/10.1074/jbc.M410722200DOI Listing
February 2005

Ras/mitogen-activated protein kinase signaling activates Ets-1 and Ets-2 by CBP/p300 recruitment.

Mol Cell Biol 2004 Dec;24(24):10954-64

Huntsman Cancer Institute, 2000 Circle of Hope, University of Utah, Salt Lake City, UT 84112-5550, USA.

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http://dx.doi.org/10.1128/MCB.24.24.10954-10964.2004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC533975PMC
December 2004

Expression profiles frame the promoter specificity dilemma of the ETS family of transcription factors.

Nucleic Acids Res 2004 21;32(18):5693-702. Epub 2004 Oct 21.

Department of Oncological Sciences, Huntsman Cancer Institute, 2000 Circle of Hope, University of Utah, Salt Lake City, UT 84112, USA.

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https://academic.oup.com/nar/article-lookup/doi/10.1093/nar/
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http://dx.doi.org/10.1093/nar/gkh906DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC524310PMC
November 2004

Autoinhibitory domains: modular effectors of cellular regulation.

Annu Rev Cell Dev Biol 2002 2;18:421-62. Epub 2002 Apr 2.

Huntsman Cancer Institute, Department of Oncological Sciences, University of Utah, 2000 Circle of Hope, Salt Lake City 84112-5550, USA.

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http://dx.doi.org/10.1146/annurev.cellbio.18.031502.133614DOI Listing
May 2003

Structural analysis of the autoinhibition of Ets-1 and its role in protein partnerships.

J Biol Chem 2002 Nov 6;277(47):45529-36. Epub 2002 Sep 6.

Department of Biophysics and Biophysical Chemistry and the Howard Hughes Medical Institute, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205-2185, USA.

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http://dx.doi.org/10.1074/jbc.M206327200DOI Listing
November 2002

Inhibitory module of Ets-1 allosterically regulates DNA binding through a dipole-facilitated phosphate contact.

J Biol Chem 2002 Jan 31;277(3):2225-33. Epub 2001 Oct 31.

Huntsman Cancer Institute, Department of Oncological Sciences, University of Utah, Salt Lake City, Utah 84112-5550, USA.

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http://dx.doi.org/10.1074/jbc.M109430200DOI Listing
January 2002

An ERK2 docking site in the Pointed domain distinguishes a subset of ETS transcription factors.

Genes Dev 2002 Jan;16(1):127-37

Huntsman Cancer Institute, Department of Oncological Sciences, University of Utah, Salt Lake City, Utah 84112-5550, USA.

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http://dx.doi.org/10.1101/gad.950902DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC155314PMC
January 2002

Ets-1 flips for new partner Pax-5.

Structure 2002 Jan;10(1):11-4

Department of Oncological Sciences, Huntsman Cancer Institute, University of Utah, 2000 Circle of Hope, Salt Lake City, UT 84112, USA.

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http://dx.doi.org/10.1016/s0969-2126(01)00701-8DOI Listing
January 2002