Barbara Chiavarina

Institut de Recherche en Cancérologie de Montpellier, Tumor Microenvironment and Resistance to Treatment Lab, Campus Val d'Aurelle, F-34298 Montpellier Cedex 5. France.

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September 2017

Methylglyoxal-Mediated Stress Correlates with High Metabolic Activity and Promotes Tumor Growth in Colorectal Cancer.

Authors:

Barbara Chiavarina Marie-Julie Nokin Justine Bellier Florence Durieux Noëlla Bletard Félicie Sherer Pierre Lovinfosse Olivier Peulen Laurine Verset Romain Dehon Pieter Demetter Andrei Turtoi Koji Uchida Serge Goldman Roland Hustinx Philippe Delvenne Vincent Castronovo Akeila Bellahcène

Int J Mol Sci 2017 Jan 21;18(1). Epub 2017 Jan 21.

Metastasis Research Laboratory, GIGA-Cancer, University of Liège, 4000 Liège, Belgium.

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January 2017

Methylglyoxal, a glycolysis side-product, induces Hsp90 glycation and YAP-mediated tumor growth and metastasis.

Elife 2016 10 19;5. Epub 2016 Oct 19.

Metastasis Research Laboratory, GIGA-CANCER, University of Liège, Liège, Belgium.

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October 2016

Triple negative tumors accumulate significantly less methylglyoxal specific adducts than other human breast cancer subtypes.

Authors:

Barbara Chiavarina Marie-Julie Nokin Florence Durieux Elettra Bianchi Andrei Turtoi Olivier Peulen Paul Peixoto Philippe Irigaray Koji Uchida Dominique Belpomme Philippe Delvenne Vincent Castronovo Akeila Bellahcène

Oncotarget 2014 Jul;5(14):5472-82

Metastasis Research Laboratory, GIGA-Cancer, University of Liège, Liège, Belgium.

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July 2014

CDK inhibitors (p16/p19/p21) induce senescence and autophagy in cancer-associated fibroblasts, "fueling" tumor growth via paracrine interactions, without an increase in neo-angiogenesis.

Authors:

Claudia Capparelli Barbara Chiavarina Diana Whitaker-Menezes Timothy G Pestell Richard G Pestell James Hulit Sebastiano Andò Anthony Howell Ubaldo E Martinez-Outschoorn Federica Sotgia Michael P Lisanti

Cell Cycle 2012 Oct 30;11(19):3599-610. Epub 2012 Aug 30.

The Jefferson Stem Cell Biology and Regenerative Medicine Center, Kimmel Cancer Center, Thomas Jefferson University, Philadelphia, PA, USA.

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October 2012

Metabolic reprogramming and two-compartment tumor metabolism: opposing role(s) of HIF1α and HIF2α in tumor-associated fibroblasts and human breast cancer cells.

Authors:

Barbara Chiavarina Ubaldo E Martinez-Outschoorn Diana Whitaker-Menezes Anthony Howell Herbert B Tanowitz Richard G Pestell Federica Sotgia Michael P Lisanti

Cell Cycle 2012 Sep 16;11(17):3280-9. Epub 2012 Aug 16.

The Jefferson Stem Cell Biology and Regenerative Medicine Center, Department of Stem Cell Biology & Regenerative Medicine, Kimmel Cancer Center, Thomas Jefferson University, Philadelphia, PA, USA.

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September 2012

Pyruvate kinase expression (PKM1 and PKM2) in cancer-associated fibroblasts drives stromal nutrient production and tumor growth.

Authors:

Barbara Chiavarina Diana Whitaker-Menezes Ubaldo E Martinez-Outschoorn Agnieszka K Witkiewicz Ruth Birbe Anthony Howell Richard G Pestell Johanna Smith Rene Daniel Federica Sotgia Michael P Lisanti

Cancer Biol Ther 2011 Dec 15;12(12):1101-13. Epub 2011 Dec 15.

Departments of Stem Cell Biology and Regenerative Medicine and Cancer Biology, Kimmel Cancer Center, Thomas Jefferson University, Philadelphia, PA, USA.

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December 2011

Mitochondrial oxidative stress in cancer-associated fibroblasts drives lactate production, promoting breast cancer tumor growth: understanding the aging and cancer connection.

Authors:

Renee M Balliet Claudia Capparelli Carmela Guido Timothy G Pestell Ubaldo E Martinez-Outschoorn Zhao Lin Diana Whitaker-Menezes Barbara Chiavarina Richard G Pestell Anthony Howell Federica Sotgia Michael P Lisanti

Cell Cycle 2011 Dec 1;10(23):4065-73. Epub 2011 Dec 1.

The Jefferson Stem Cell Biology and Regenerative Medicine Center, Department of Stem Cell Biology and Regenerative Medicine, Thomas Jefferson University, Philadelphia, PA, USA.

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December 2011

The autophagic tumor stroma model of cancer or "battery-operated tumor growth": A simple solution to the autophagy paradox.

Authors:

Ubaldo E Martinez-Outschoorn Diana Whitaker-Menezes Stephanos Pavlides Barbara Chiavarina Gloria Bonuccelli Trimmer Casey Aristotelis Tsirigos Gemma Migneco Agnieszka Witkiewicz Renee Balliet Isabelle Mercier Chengwang Wang Neal Flomenberg Anthony Howell Zhao Lin Jaime Caro Richard G Pestell Federica Sotgia Michael P Lisanti

Cell Cycle 2010 Nov 30;9(21):4297-306. Epub 2010 Nov 30.

The Jefferson Stem Cell Biology and Regenerative Medicine Center, Thomas Jefferson University, Philadelphia, PA, USA.

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November 2010

HIF1-alpha functions as a tumor promoter in cancer associated fibroblasts, and as a tumor suppressor in breast cancer cells: Autophagy drives compartment-specific oncogenesis.

Authors:

Barbara Chiavarina Diana Whitaker-Menezes Gemma Migneco Ubaldo E Martinez-Outschoorn Stephanos Pavlides Anthony Howell Herbert B Tanowitz Mathew C Casimiro Chenguang Wang Richard G Pestell Philip Grieshaber Jaime Caro Federica Sotgia Michael P Lisanti

Cell Cycle 2010 Sep 4;9(17):3534-51. Epub 2010 Sep 4.

Department of Stem Cell Biology & Regenerative Medicine, Kimmel Cancer Center, Thomas Jefferson University, Philadelphia, PA, USA.

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September 2010

The autophagic tumor stroma model of cancer: Role of oxidative stress and ketone production in fueling tumor cell metabolism.

Authors:

Stephanos Pavlides Aristotelis Tsirigos Gemma Migneco Diana Whitaker-Menezes Barbara Chiavarina Neal Flomenberg Philippe G Frank Mathew C Casimiro Chenguang Wang Richard G Pestell Ubaldo E Martinez-Outschoorn Anthony Howell Federica Sotgia Michael P Lisanti

Cell Cycle 2010 Sep;9(17):3485-505

Department of Stem Cell Biology and Regenerative Medicine, Kimmel Cancer Center, Thomas Jefferson University, Philadelphia, PA, USA.

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September 2010

Understanding the "lethal" drivers of tumor-stroma co-evolution: emerging role(s) for hypoxia, oxidative stress and autophagy/mitophagy in the tumor micro-environment.

Authors:

Michael P Lisanti Ubaldo E Martinez-Outschoorn Barbara Chiavarina Stephanos Pavlides Diana Whitaker-Menezes Aristotelis Tsirigos Agnieszka Witkiewicz Zhao Lin Renee Balliet Anthony Howell Federica Sotgia

Cancer Biol Ther 2010 Sep 19;10(6):537-42. Epub 2010 Sep 19.

The Jefferson Stem Cell Biology and Regenerative Medicine Center, Department of Medical Oncology, Kimmel Cancer Center, Thomas Jefferson University, Philadelphia, PA, USA.

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September 2010

Autophagy in cancer associated fibroblasts promotes tumor cell survival: Role of hypoxia, HIF1 induction and NFκB activation in the tumor stromal microenvironment.

Authors:

Ubaldo E Martinez-Outschoorn Casey Trimmer Zhao Lin Diana Whitaker-Menezes Barbara Chiavarina Jie Zhou Chengwang Wang Stephanos Pavlides Maria P Martinez-Cantarin Franco Capozza Agnieszka K Witkiewicz Neal Flomenberg Anthony Howell Richard G Pestell Jaime Caro Michael P Lisanti Federica Sotgia

Cell Cycle 2010 Sep 9;9(17):3515-33. Epub 2010 Sep 9.

Department of Medical Oncology and The Jefferson Stem Cell Biology and Regenerative Medicine Center, Thomas Jefferson University, Philadelphia, PA, USA.

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September 2010

Ketones and lactate "fuel" tumor growth and metastasis: Evidence that epithelial cancer cells use oxidative mitochondrial metabolism.

Authors:

Gloria Bonuccelli Aristotelis Tsirigos Diana Whitaker-Menezes Stephanos Pavlides Richard G Pestell Barbara Chiavarina Philippe G Frank Neal Flomenberg Anthony Howell Ubaldo E Martinez-Outschoorn Federica Sotgia Michael P Lisanti

Cell Cycle 2010 Sep 21;9(17):3506-14. Epub 2010 Sep 21.

Department of Stem Cell Biology & Regenerative Medicine, Kimmel Cancer Center, Thomas Jefferson University, Philadelphia, PA, USA.

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September 2010

Oxidative stress in cancer associated fibroblasts drives tumor-stroma co-evolution: A new paradigm for understanding tumor metabolism, the field effect and genomic instability in cancer cells.

Authors:

Ubaldo E Martinez-Outschoorn Renee M Balliet Dayana B Rivadeneira Barbara Chiavarina Stephanos Pavlides Chenguang Wang Diana Whitaker-Menezes Kristin M Daumer Zhao Lin Agnieszka K Witkiewicz Neal Flomenberg Anthony Howell Richard G Pestell Erik S Knudsen Federica Sotgia Michael P Lisanti

Cell Cycle 2010 Aug 28;9(16):3256-76. Epub 2010 Aug 28.

Department of Medical Oncology, Thomas Jefferson University, Philadelphia, PA, USA.

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August 2010

Glycolytic cancer associated fibroblasts promote breast cancer tumor growth, without a measurable increase in angiogenesis: evidence for stromal-epithelial metabolic coupling.

Authors:

Gemma Migneco Diana Whitaker-Menezes Barbara Chiavarina Remedios Castello-Cros Stephanos Pavlides Richard G Pestell Alessandro Fatatis Neal Flomenberg Aristotelis Tsirigos Anthony Howell Ubaldo E Martinez-Outschoorn Federica Sotgia Michael P Lisanti

Cell Cycle 2010 Jun 15;9(12):2412-22. Epub 2010 Jun 15.

Department of Stem Cell Biology & Regenerative Medicine, Thomas Jefferson University, Philadelphia, PA, USA.

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June 2010

Tumor cells induce the cancer associated fibroblast phenotype via caveolin-1 degradation: implications for breast cancer and DCIS therapy with autophagy inhibitors.

Authors:

Ubaldo E Martinez-Outschoorn Stephanos Pavlides Diana Whitaker-Menezes Kristin M Daumer Janet N Milliman Barbara Chiavarina Gemma Migneco Agnieszka K Witkiewicz Maria P Martinez-Cantarin Neal Flomenberg Anthony Howell Richard G Pestell Michael P Lisanti Federica Sotgia

Cell Cycle 2010 Jun 15;9(12):2423-33. Epub 2010 Jun 15.

Department of Medical Oncology, Thomas Jefferson University, Philadelphia, PA, USA.

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June 2010

The reverse Warburg effect: glycolysis inhibitors prevent the tumor promoting effects of caveolin-1 deficient cancer associated fibroblasts.

Authors:

Gloria Bonuccelli Diana Whitaker-Menezes Remedios Castello-Cros Stephanos Pavlides Richard G Pestell Alessandro Fatatis Agnieszka K Witkiewicz Matthew G Vander Heiden Gemma Migneco Barbara Chiavarina Philippe G Frank Franco Capozza Neal Flomenberg Ubaldo E Martinez-Outschoorn Federica Sotgia Michael P Lisanti

Cell Cycle 2010 May 15;9(10):1960-71. Epub 2010 May 15.

Department of Stem Cell Biology and Regenerative Medicine, Thomas Jefferson University, Philadelphia, PA, USA.

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May 2010

Endothelial colony-forming cells from patients with chronic myeloproliferative disorders lack the disease-specific molecular clonality marker.

Blood 2009 Oct 23;114(14):3127-30. Epub 2009 Jul 23.

Divisione Ematologia, Ospedale San Martino, Genova.

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October 2009

Mesenchymal stem cells protective effect in adriamycin model of nephropathy.

Authors:

Alberto Magnasco Mirko Corselli Roberta Bertelli Adalberto Ibatici Monica Peresi Gabriele Gaggero Valentina Cappiello Barbara Chiavarina Girolamo Mattioli Rosanna Gusmano Jean Louis Ravetti Francesco Frassoni Gian Marco Ghiggeri

Cell Transplant 2008 ;17(10-11):1157-67

Department of Nephrology, G. Gaslini Children Hospital, Genoa, Italy.

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February 2009

Diabetes impairs the vascular recruitment of normal stem cells by oxidant damage, reversed by increases in pAMPK, heme oxygenase-1, and adiponectin.

Authors:

Gianmario Sambuceti Silvia Morbelli Luca Vanella Claudia Kusmic Cecilia Marini Michela Massollo Carla Augeri Mirko Corselli Chiara Ghersi Barbara Chiavarina Luigi F Rodella Antonio L'Abbate George Drummond Nader G Abraham Francesco Frassoni

Stem Cells 2009 Feb;27(2):399-407

Department of Internal Medicine, University of Genoa, S. Martino Hospital, Genoa, Italy.

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February 2009

Study of feasibility of the treatment with procainamide hydrochloride and cisplatin in pregnant mice.

Authors:

Emanuela Ognio Barbara Chiavarina Miroslav Peterka Maria A Mariggiò Maurizio Viale

Chem Biol Interact 2006 Dec 10;164(3):232-40. Epub 2006 Oct 10.

Istituto Nazionale per la Ricerca sul Cancro, SS Sperimentazioni su Modelli Animali, Lgo R Benzi, 10, 16132 Genova, Italy.

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December 2006

Morphological and histochemical evidence of the protective effect of procainamide hydrochloride on tissue damage induced by repeated administration of low doses of cisplatin.

Authors:

Carla Fenoglio Eleonora Boncompagni Barbara Chiavarina Sergio Cafaggi Michele Cilli Maurizio Viale

Anticancer Res 2005 Nov-Dec;25(6B):4123-8

Dipartimento di Biologia Animale, Università di Pavia, P.za Botta 10, 27100 Pavia.

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January 2006

Inhibition of cell proliferation, cytotoxicity and induction of apoptosis of 1,4-bis(1-naphthyl)-2,3-dinitro-1,3-butadiene in gastrointestinal tumour cell lines and preliminary evaluation of its toxicity in vivo.

Authors:

Carlo Dell'Erba Barbara Chiavarina Carla Fenoglio Giovanni Petrillo Cinzia Cordazzo Eleonora Boncompagni Domenico Spinelli Emanuela Ognio Cinzia Aiello Maria A Mariggiò Maurizio Viale

Pharmacol Res 2005 Sep;52(3):271-82

Dipartimento di Chimica e Chimica Industriale, Università di Genova, Via Dodecaneso 31, 16146 Genova, Italy.

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September 2005

Preliminary evaluation in vitro of the inhibition of cell proliferation, cytotoxicity and induction of apoptosis by 1,4-bis(1-naphthyl)-2,3-dinitro-1,3-butadiene.

Authors:

Maurizio Viale Maria A Mariggiò Massimo Ottone Barbara Chiavarina Angela Vinella Claudia Prevosto Carlo Dell'Erba Giovanni Petrillo Marino Novi

Invest New Drugs 2004 Nov;22(4):359-67

Istituto Nazionale per la Ricerca sul Cancro, S.C. di Farmacologia e Neuroscienze, Lgo R. Benzi 10, 16132 Genova, Italy.

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November 2004

1,4-Bis(1-naphthyl)-2,3-dinitro-1,3-butadiene a novel anticancer compound effective against tumor cell lines characterized by different mechanisms of resistance.

Authors:

Marino Novi Massimo Ottone Carlo Dell'Erba Federica Barbieri Barbara Chiavarina Massimo Maccagno Maurizio Viale

Oncol Rep 2004 Jul;12(1):91-6

Dipartimento di Chimica e Chimica Industriale, Università di Genova, 16146 Genova, Italy.

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July 2004

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