Barbara B Kahn

Barbara B Kahn

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Barbara B Kahn

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PAHSAs enhance hepatic and systemic insulin sensitivity through direct and indirect mechanisms.

J Clin Invest 2019 Oct;129(10):4138-4150

Division of Endocrinology, Diabetes and Metabolism, Department of Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts, USA.

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http://dx.doi.org/10.1172/JCI127092DOI Listing
October 2019

PAHSAs attenuate immune responses and promote β cell survival in autoimmune diabetic mice.

J Clin Invest 2019 08 5;129:3717-3731. Epub 2019 Aug 5.

Division of Endocrinology, Diabetes and Metabolism, Department of Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts, USA.

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http://dx.doi.org/10.1172/JCI122445DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6715391PMC
August 2019

Discovery of FAHFA-Containing Triacylglycerols and Their Metabolic Regulation.

J Am Chem Soc 2019 Jun 13;141(22):8798-8806. Epub 2019 May 13.

Clayton Foundation Laboratories for Peptide Biology , Salk Institute for Biological Studies , 10010 North Torrey Pines Road , La Jolla , California 92037-1002 , United States.

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http://dx.doi.org/10.1021/jacs.9b00045DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6662584PMC
June 2019

Adipose Tissue, Inter-Organ Communication, and the Path to Type 2 Diabetes: The 2016 Banting Medal for Scientific Achievement Lecture.

Authors:
Barbara B Kahn

Diabetes 2019 01;68(1):3-14

Division of Endocrinology, Diabetes and Metabolism, Department of Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA

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http://dx.doi.org/10.2337/dbi18-0035DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6302542PMC
January 2019

Brown Adipose Tissue Controls Skeletal Muscle Function via the Secretion of Myostatin.

Cell Metab 2018 10 2;28(4):631-643.e3. Epub 2018 Aug 2.

Division of Endocrinology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA; Broad Institute, Cambridge, MA 02142, USA. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S15504131183044
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http://dx.doi.org/10.1016/j.cmet.2018.07.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6170693PMC
October 2018

Metabolites as regulators of insulin sensitivity and metabolism.

Nat Rev Mol Cell Biol 2018 10;19(10):654-672

Division of Endocrinology, Diabetes and Metabolism, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA, USA.

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http://www.nature.com/articles/s41580-018-0044-8
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http://dx.doi.org/10.1038/s41580-018-0044-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6380503PMC
October 2018

Methodological Issues in Studying PAHSA Biology: Masking PAHSA Effects.

Cell Metab 2018 10 20;28(4):543-546. Epub 2018 Sep 20.

Division of Endocrinology, Diabetes, and Metabolism, Department of Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, 330 Brookline Avenue, Boston, MA 02215, USA. Electronic address:

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http://dx.doi.org/10.1016/j.cmet.2018.09.007DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6542592PMC
October 2018

Adipose tissue dysfunction is associated with low levels of the novel Palmitic Acid Hydroxystearic Acids.

Sci Rep 2018 10 25;8(1):15757. Epub 2018 Oct 25.

The Lundberg Laboratory for Diabetes Research, Departments of Molecular and Clinical Medicine, Institute of Medicine, Sahlgrenska Academy at the University of Gothenburg, Gothenburg, Sweden.

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http://www.nature.com/articles/s41598-018-34113-3
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http://dx.doi.org/10.1038/s41598-018-34113-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6202399PMC
October 2018

Faster Protocol for Endogenous Fatty Acid Esters of Hydroxy Fatty Acid (FAHFA) Measurements.

Anal Chem 2018 04 26;90(8):5358-5365. Epub 2018 Mar 26.

Clayton Foundation Laboratories for Peptide Biology , Salk Institute for Biological Studies , 10010 North Torrey Pines Road , La Jolla , California 92037 , United States.

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http://dx.doi.org/10.1021/acs.analchem.8b00503DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5962352PMC
April 2018

Palmitic Acid Hydroxystearic Acids Activate GPR40, Which Is Involved in Their Beneficial Effects on Glucose Homeostasis.

Cell Metab 2018 02;27(2):419-427.e4

Division of Endocrinology, Diabetes, and Metabolism, Department of Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, Center for Life Sciences, Room 747, 330 Brookline Avenue, Boston, MA 02215, USA. Electronic address:

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http://dx.doi.org/10.1016/j.cmet.2018.01.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5807007PMC
February 2018

Activation of AMPK-Regulated CRH Neurons in the PVH is Sufficient and Necessary to Induce Dietary Preference for Carbohydrate over Fat.

Cell Rep 2018 01;22(3):706-721

Division of Endocrinology and Metabolism, Department of Homeostatic Regulation, National Institute for Physiological Sciences, National Institute of Natural Sciences, 38 Nishigonaka, Myodaiji, Okazaki, Aichi 444-8585, Japan; Department of Physiological Sciences, School of Life Science, SOKENDAI (The Graduate University for Advanced Studies), 38 Nishigonaka, Myodaiji, Okazaki, Aichi 444-8585, Japan. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2017.11.102DOI Listing
January 2018

GLUT4 Is Not Necessary for Overload-Induced Glucose Uptake or Hypertrophic Growth in Mouse Skeletal Muscle.

Diabetes 2017 06 9;66(6):1491-1500. Epub 2017 Mar 9.

Department of Kinesiology, East Carolina University, Greenville, NC

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http://dx.doi.org/10.2337/db16-1075DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5440020PMC
June 2017

Stereochemistry of Endogenous Palmitic Acid Ester of 9-Hydroxystearic Acid and Relevance of Absolute Configuration to Regulation.

J Am Chem Soc 2017 04 28;139(13):4943-4947. Epub 2017 Mar 28.

Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California-San Diego , 9500 Gilman Drive, La Jolla, California 92093-0934, United States.

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http://pubs.acs.org/doi/10.1021/jacs.7b01269
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http://dx.doi.org/10.1021/jacs.7b01269DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5568760PMC
April 2017

Brain GLUT4 Knockout Mice Have Impaired Glucose Tolerance, Decreased Insulin Sensitivity, and Impaired Hypoglycemic Counterregulation.

Diabetes 2017 03 17;66(3):587-597. Epub 2016 Oct 17.

Division of Endocrinology, Metabolism, and Lipid Research, Department of Medicine, Washington University in St. Louis, St. Louis, MO

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http://dx.doi.org/10.2337/db16-0917DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5319720PMC
March 2017

Adipocyte-specific overexpression of retinol-binding protein 4 causes hepatic steatosis in mice.

Hepatology 2016 11 4;64(5):1534-1546. Epub 2016 Jul 4.

Department of Medicine, College of Physicians and Surgeons, Columbia University, New York, NY.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5074895PMC
http://dx.doi.org/10.1002/hep.28659DOI Listing
November 2016

Branched Fatty Acid Esters of Hydroxy Fatty Acids Are Preferred Substrates of the MODY8 Protein Carboxyl Ester Lipase.

Biochemistry 2016 08 10;55(33):4636-41. Epub 2016 Aug 10.

Peptide Biology Laboratories, Helmsley Center for Genomic Medicine, Salk Institute for Biological Studies , La Jolla, California 92037, United States.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5056623PMC
http://dx.doi.org/10.1021/acs.biochem.6b00565DOI Listing
August 2016

GLUT4 Expression in Adipocytes Regulates De Novo Lipogenesis and Levels of a Novel Class of Lipids With Antidiabetic and Anti-inflammatory Effects.

Diabetes 2016 07 10;65(7):1808-15. Epub 2016 Jun 10.

Division of Endocrinology, Diabetes, and Metabolism, Department of Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA

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http://dx.doi.org/10.2337/db16-0221DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4915575PMC
July 2016

A Postsynaptic AMPK→p21-Activated Kinase Pathway Drives Fasting-Induced Synaptic Plasticity in AgRP Neurons.

Neuron 2016 07 16;91(1):25-33. Epub 2016 Jun 16.

Division of Endocrinology, Diabetes, and Metabolism, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, 3 Blackfan Circle, Boston, MA 02215, USA; Program in Neuroscience, Harvard Medical School, Boston, MA 02115, USA. Electronic address:

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http://dx.doi.org/10.1016/j.neuron.2016.05.025DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4938763PMC
July 2016

Antigen Presentation and T-Cell Activation Are Critical for RBP4-Induced Insulin Resistance.

Diabetes 2016 05 2;65(5):1317-27. Epub 2016 Mar 2.

Division of Endocrinology, Diabetes and Metabolism, Department of Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA

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http://dx.doi.org/10.2337/db15-1696DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4839203PMC
May 2016

AIG1 and ADTRP are atypical integral membrane hydrolases that degrade bioactive FAHFAs.

Nat Chem Biol 2016 May 28;12(5):367-372. Epub 2016 Mar 28.

The Skaggs Institute for Chemical Biology, Department of Chemical Physiology, The Scripps Research Institute, La Jolla, CA 92037.

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http://dx.doi.org/10.1038/nchembio.2051DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4837090PMC
May 2016

PKD1 Inhibits AMPKα2 through Phosphorylation of Serine 491 and Impairs Insulin Signaling in Skeletal Muscle Cells.

J Biol Chem 2016 Mar 21;291(11):5664-75. Epub 2016 Jan 21.

From the Endocrinology, Diabetes, and Nutrition Section, Department of Medicine, Boston University School of Medicine, Boston, Massachusetts 02118,

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http://dx.doi.org/10.1074/jbc.M115.696849DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4786706PMC
March 2016

Novel role for retinol-binding protein 4 in the regulation of blood pressure.

FASEB J 2015 Aug 24;29(8):3133-40. Epub 2015 Apr 24.

*Division of Endocrinology, Diabetes, and Metabolism, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts, USA; Cardiovascular Medicine Division, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, USA, and Department of Medicine, College of Physicians and Surgeons, Columbia University, New York, New York, USA

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http://dx.doi.org/10.1096/fj.14-266064DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4511195PMC
August 2015

Transthyretin Antisense Oligonucleotides Lower Circulating RBP4 Levels and Improve Insulin Sensitivity in Obese Mice.

Diabetes 2015 May 18;64(5):1603-14. Epub 2014 Dec 18.

Division of Endocrinology, Diabetes and Metabolism, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA

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http://dx.doi.org/10.2337/db14-0970DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4407860PMC
May 2015

Lipid Extraction from Mouse Feces.

Bio Protoc 2015 Jan;5(1)

Department of Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4838042PMC
January 2015

Data-driven synthesis of proteolysis-resistant peptide hormones.

J Am Chem Soc 2014 Dec 12;136(51):17710-3. Epub 2014 Dec 12.

Department of Chemistry and Chemical Biology, Harvard University , Cambridge, Massachusetts 02138, United States.

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http://dx.doi.org/10.1021/ja5065735DOI Listing
December 2014

Nicotinamide N-methyltransferase knockdown protects against diet-induced obesity.

Nature 2014 Apr;508(7495):258-62

Division of Endocrinology, Diabetes, and Metabolism, Department of Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, 330 Brookline Avenue, Boston, Massachusetts 02215, USA.

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http://dx.doi.org/10.1038/nature13198DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4107212PMC
April 2014

Downregulation of STRA6 in adipocytes and adipose stromovascular fraction in obesity and effects of adipocyte-specific STRA6 knockdown in vivo.

Mol Cell Biol 2014 Mar 13;34(6):1170-86. Epub 2014 Jan 13.

Division of Endocrinology, Diabetes, and Metabolism, Department of Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts, USA.

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http://dx.doi.org/10.1128/MCB.01106-13DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3958040PMC
March 2014

RBP4 activates antigen-presenting cells, leading to adipose tissue inflammation and systemic insulin resistance.

Cell Metab 2014 Mar;19(3):512-26

Division of Endocrinology, Diabetes, and Metabolism, Department of Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, 330 Brookline Avenue, Boston, MA 02215, USA. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S15504131140002
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http://dx.doi.org/10.1016/j.cmet.2014.01.018DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4078000PMC
March 2014

Leptin, GABA, and glucose control.

Cell Metab 2013 Sep;18(3):304-6

Division of Endocrinology, Diabetes, and Metabolism, Department of Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA 02215, USA. Electronic address:

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http://dx.doi.org/10.1016/j.cmet.2013.08.015DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4097301PMC
September 2013

Application of combined omics platforms to accelerate biomedical discovery in diabesity.

Ann N Y Acad Sci 2013 May 9;1287:1-16. Epub 2013 May 9.

Department of Medicine, Stable Isotope and Metabolomics Core Facility, Albert Einstein College of Medicine Diabetes Center, Bronx, New York 10461, USA.

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http://dx.doi.org/10.1111/nyas.12116DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3709136PMC
May 2013

Lessons on conditional gene targeting in mouse adipose tissue.

Diabetes 2013 Mar 15;62(3):864-74. Epub 2013 Jan 15.

Section on Integrative Physiology and Metabolism, Joslin Diabetes Center, Harvard Medical School, Boston, Massachusetts, USA.

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http://dx.doi.org/10.2337/db12-1089DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3581196PMC
March 2013

Ca2+/calmodulin-dependent protein kinase kinase is not involved in hypothalamic AMP-activated protein kinase activation by neuroglucopenia.

PLoS One 2012 10;7(5):e36335. Epub 2012 May 10.

Division of Endocrinology, Diabetes and Metabolism, Department of Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0036335PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3349669PMC
September 2012

Adipose tissue dysregulation and reduced insulin sensitivity in non-obese individuals with enlarged abdominal adipose cells.

Diabetol Metab Syndr 2012 Sep 19;4(1):42. Epub 2012 Sep 19.

The Lundberg Laboratory for Diabetes Research, Center of Excellence for Metabolic and Cardiovascular Research, Department of Molecular and Clinical Medicine, the Sahlgrenska Academy at the University of Gothenburg, Gothenburg, SE-413 45, Sweden.

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http://dx.doi.org/10.1186/1758-5996-4-42DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3523053PMC
September 2012

p70S6 kinase phosphorylates AMPK on serine 491 to mediate leptin's effect on food intake.

Cell Metab 2012 Jul 21;16(1):104-12. Epub 2012 Jun 21.

Division of Endocrinology, Diabetes, and Metabolism, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA.

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http://dx.doi.org/10.1016/j.cmet.2012.05.010DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3407689PMC
July 2012

A novel ChREBP isoform in adipose tissue regulates systemic glucose metabolism.

Nature 2012 Apr;484(7394):333-8

Division of Endocrinology, Diabetes and Metabolism, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts 02215, USA.

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http://dx.doi.org/10.1038/nature10986DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3341994PMC
April 2012

Quantitative measurement of full-length and C-terminal proteolyzed RBP4 in serum of normal and insulin-resistant humans using a novel mass spectrometry immunoassay.

Endocrinology 2012 Mar 17;153(3):1519-27. Epub 2012 Jan 17.

Division of Endocrinology, Diabetes and Metabolism, Department of Medicine, Beth Israel Deaconess Medical Center, CLS 747, 330 Brookline Avenue, Boston, Massachusetts 02215, USA.

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http://dx.doi.org/10.1210/en.2011-1750DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3281532PMC
March 2012

CREB and ChREBP oppositely regulate SIRT1 expression in response to energy availability.

EMBO Rep 2011 Sep 30;12(10):1069-76. Epub 2011 Sep 30.

Ecole Polytechnique Fédérale de Lausanne, Laboratory of Integrative and Systems Physiology and Nestlé Chair in Energy Metabolism, 1015 Lausanne, Switzerland.

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http://dx.doi.org/10.1038/embor.2011.151DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3185337PMC
September 2011

Adrenergic regulation of AMP-activated protein kinase in brown adipose tissue in vivo.

J Biol Chem 2011 Mar 5;286(11):8798-809. Epub 2011 Jan 5.

Division of Endocrinology, Diabetes, and Metabolism, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts 02215, USA.

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http://www.jbc.org/content/286/11/8798.full.pdf
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http://www.jbc.org/cgi/doi/10.1074/jbc.M111.218719
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http://dx.doi.org/10.1074/jbc.M111.218719DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3059037PMC
March 2011

Rosiglitazone, PPARγ, and type 2 diabetes.

N Engl J Med 2010 Dec;363(27):2667-9

Division of Endocrinology, Diabetes, and Metabolism, Beth Israel Deaconess Medical Center, and Harvard Medical School, Boston, USA.

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http://dx.doi.org/10.1056/NEJMcibr1012075DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3733169PMC
December 2010

Macrophage alpha1 AMP-activated protein kinase (alpha1AMPK) antagonizes fatty acid-induced inflammation through SIRT1.

J Biol Chem 2010 Jun 26;285(25):19051-9. Epub 2010 Apr 26.

Department of Internal Medicine, Wake Forest University School of Medicine, Winston-Salem, North Carolina 27157, USA.

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http://www.jbc.org/lookup/doi/10.1074/jbc.M110.123620
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http://dx.doi.org/10.1074/jbc.M110.123620DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2885183PMC
June 2010

Adipose tissue branched chain amino acid (BCAA) metabolism modulates circulating BCAA levels.

J Biol Chem 2010 Apr 21;285(15):11348-56. Epub 2010 Jan 21.

Division of Endocrinology, Diabetes and Metabolism, Beth Israel Deaconess Medical Center, and Department of Medicine, Harvard Medical School, Boston, Massachusetts 02215, USA.

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http://dx.doi.org/10.1074/jbc.M109.075184DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2857013PMC
April 2010

Leveraging leptin for type I diabetes?

Proc Natl Acad Sci U S A 2010 Mar 8;107(11):4793-4. Epub 2010 Mar 8.

Division of Endocrinology, Diabetes, and Metabolism, Department of Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA 02215, USA.

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http://dx.doi.org/10.1073/pnas.1000736107DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2841872PMC
March 2010

Long-term Fenretinide treatment prevents high-fat diet-induced obesity, insulin resistance, and hepatic steatosis.

Am J Physiol Endocrinol Metab 2009 Dec 13;297(6):E1420-9. Epub 2009 Oct 13.

Division of Endocrinology, Diabetes, and Metabolism, Department of Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts, USA.

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http://dx.doi.org/10.1152/ajpendo.00362.2009DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2793052PMC
December 2009

Impact of type 1 diabetes and insulin treatment on plasma levels and fractional synthesis rate of retinol-binding protein 4.

J Clin Endocrinol Metab 2009 Dec 22;94(12):5125-30. Epub 2009 Oct 22.

Division of Endocrinology and Metabolism, Endocrine Research Unit, Mayo Clinic, Rochester, Minnesota 55905, USA.

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https://academic.oup.com/jcem/article-lookup/doi/10.1210/jc.
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http://dx.doi.org/10.1210/jc.2009-1331DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2795661PMC
December 2009

Phosphatidyl inositol 3-kinase signaling in hypothalamic proopiomelanocortin neurons contributes to the regulation of glucose homeostasis.

Endocrinology 2009 Nov 9;150(11):4874-82. Epub 2009 Oct 9.

Division of Hypothalamic Research, Department of Internal Medicine, The University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, Texas 75390-9077, USA.

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https://academic.oup.com/endo/article-lookup/doi/10.1210/en.
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http://dx.doi.org/10.1210/en.2009-0454DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2775989PMC
November 2009

Retinol-binding protein 4 (RBP4): a biomarker for subclinical atherosclerosis?

Am J Hypertens 2009 Sep;22(9):948-9

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http://dx.doi.org/10.1038/ajh.2009.124DOI Listing
September 2009

Deletion of cd39/entpd1 results in hepatic insulin resistance.

Diabetes 2008 Sep 20;57(9):2311-20. Epub 2008 Jun 20.

Liver Center, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts, USA.

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http://dx.doi.org/10.2337/db07-1265DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2518482PMC
September 2008

Protein-tyrosine phosphatase 1B expression is induced by inflammation in vivo.

J Biol Chem 2008 May 14;283(21):14230-41. Epub 2008 Feb 14.

Division of Endocrinology, Diabetes, and Metabolism and Cancer Biology Program, Department of Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA 02215, USA.

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http://dx.doi.org/10.1074/jbc.M800061200DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2386946PMC
May 2008

Decreased clearance of serum retinol-binding protein and elevated levels of transthyretin in insulin-resistant ob/ob mice.

Am J Physiol Endocrinol Metab 2008 Apr 19;294(4):E785-93. Epub 2008 Feb 19.

Division of Endocrinology, Diabetes and Metabolism, Department of Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA 02215, USA.

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http://dx.doi.org/10.1152/ajpendo.00521.2007DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2711779PMC
April 2008

Improved glucose homeostasis in mice with muscle-specific deletion of protein-tyrosine phosphatase 1B.

Mol Cell Biol 2007 Nov 27;27(21):7727-34. Epub 2007 Aug 27.

Cancer Biology Program, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts, USA.

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http://dx.doi.org/10.1128/MCB.00959-07DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2169063PMC
November 2007

Protein-tyrosine phosphatase 1B deficiency reduces insulin resistance and the diabetic phenotype in mice with polygenic insulin resistance.

J Biol Chem 2007 Aug 1;282(33):23829-40. Epub 2007 Jun 1.

Division of Endocrinology, Diabetes, and Metabolism, Beth Israel Deaconess Medical Center, Boston, Massachusetts 02215, USA.

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http://dx.doi.org/10.1074/jbc.M609680200DOI Listing
August 2007

Cathepsin L activity controls adipogenesis and glucose tolerance.

Nat Cell Biol 2007 Aug 22;9(8):970-7. Epub 2007 Jul 22.

Cardiovascular Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA.

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http://dx.doi.org/10.1038/ncb1623DOI Listing
August 2007

A high-fat, ketogenic diet induces a unique metabolic state in mice.

Am J Physiol Endocrinol Metab 2007 Jun 13;292(6):E1724-39. Epub 2007 Feb 13.

Division of Endocrinology, Departmentof Medicine, Beth Israel Deaconess Medical Center, 330 Brookline Ave., Boston, MA 02215, USA.

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http://dx.doi.org/10.1152/ajpendo.00717.2006DOI Listing
June 2007

Reduction of elevated serum retinol binding protein in obese children by lifestyle intervention: association with subclinical inflammation.

J Clin Endocrinol Metab 2007 May 6;92(5):1971-4. Epub 2007 Mar 6.

Mayo Clinic College of Medicine, and Nemours Children's Clinic, 807 Children's Way, Jacksonville, FL 32207, USA.

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http://dx.doi.org/10.1210/jc.2006-2712DOI Listing
May 2007

Regulation of gluconeogenesis by Krüppel-like factor 15.

Cell Metab 2007 Apr;5(4):305-12

Cardiovascular Division, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA.

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http://dx.doi.org/10.1016/j.cmet.2007.03.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1892530PMC
April 2007

Role of hypothalamic adenosine 5'-monophosphate-activated protein kinase in the impaired counterregulatory response induced by repetitive neuroglucopenia.

Endocrinology 2007 Mar 21;148(3):1367-75. Epub 2006 Dec 21.

Division of Endocrinology, Diabetes and Metabolism, Beth Israel Deaconess Medical Center, 99 Brookline Avenue, Boston, MA 02215, USA.

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http://dx.doi.org/10.1210/en.2006-1039DOI Listing
March 2007

Neuronal PTP1B regulates body weight, adiposity and leptin action.

Nat Med 2006 Aug 16;12(8):917-24. Epub 2006 Jul 16.

Cancer Biology Program, Division of Hematology/Oncology, Department of Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, NRB 1030, 77 Avenue Louis Pasteur, Boston, Massachusetts 02115, USA.

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http://www.nature.com/articles/nm1435
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http://dx.doi.org/10.1038/nm1435DOI Listing
August 2006

Diet-induced obesity alters AMP kinase activity in hypothalamus and skeletal muscle.

J Biol Chem 2006 Jul 10;281(28):18933-41. Epub 2006 May 10.

Division of Endocrinology, Diabetes, and Metabolism, Department of Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts 02215, USA.

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http://dx.doi.org/10.1074/jbc.M512831200DOI Listing
July 2006

AMPK integrates nutrient and hormonal signals to regulate food intake and energy balance through effects in the hypothalamus and peripheral tissues.

J Physiol 2006 Jul 18;574(Pt 1):73-83. Epub 2006 May 18.

Division of Endocrinology, Diabetes and Metabolism, Beth Israel Deaconess Medical Center, 330 Brookline Avenue, Research North 380C, Boston, MA 02215, USA.

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http://dx.doi.org/10.1113/jphysiol.2006.113217DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1817809PMC
July 2006

Glucose transport and sensing in the maintenance of glucose homeostasis and metabolic harmony.

J Clin Invest 2006 Jul;116(7):1767-75

Division of Endocrinology, Diabetes and Metabolism, Department of Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts 02215, USA.

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http://www.jci.org/cgi/doi/10.1172/JCI29027
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http://dx.doi.org/10.1172/JCI29027DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1483149PMC
July 2006

mTOR tells the brain that the body is hungry.

Nat Med 2006 Jun;12(6):615-7

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http://dx.doi.org/10.1038/nm0606-615DOI Listing
June 2006

Retinol-binding protein 4 and insulin resistance in lean, obese, and diabetic subjects.

N Engl J Med 2006 Jun;354(24):2552-63

Division of Endocrinology, Diabetes, and Metabolism, Department of Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA 02215, USA.

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http://dx.doi.org/10.1056/NEJMoa054862DOI Listing
June 2006

Muscle-specific deletion of the Glut4 glucose transporter alters multiple regulatory steps in glycogen metabolism.

Mol Cell Biol 2005 Nov;25(21):9713-23

Division of Endocrinology, Diabetes and Metabolism, Beth Israel Deaconess Medical Center, 99 Brookline Avenue, Boston, MA 02215, USA.

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http://dx.doi.org/10.1128/MCB.25.21.9713-9723.2005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1265843PMC
November 2005

Adipose-specific overexpression of GLUT4 reverses insulin resistance and diabetes in mice lacking GLUT4 selectively in muscle.

Am J Physiol Endocrinol Metab 2005 Oct 31;289(4):E551-61. Epub 2005 May 31.

Division of Endocrinology, Diabetes, and Metabolism, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA.

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http://www.physiology.org/doi/10.1152/ajpendo.00116.2005
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October 2005

Role of Rho-kinase in regulation of insulin action and glucose homeostasis.

Cell Metab 2005 Aug;2(2):119-29

Division of Endocrinology, Diabetes and Metabolism, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts 02215, USA.

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http://dx.doi.org/10.1016/j.cmet.2005.06.011DOI Listing
August 2005

Serum retinol binding protein 4 contributes to insulin resistance in obesity and type 2 diabetes.

Nature 2005 Jul;436(7049):356-62

Division of Endocrinology, Diabetes and Metabolism, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts 02215, USA.

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http://dx.doi.org/10.1038/nature03711DOI Listing
July 2005

Insulin resistance in the skeletal muscle of women with PCOS involves intrinsic and acquired defects in insulin signaling.

Am J Physiol Endocrinol Metab 2005 May 21;288(5):E1047-54. Epub 2004 Dec 21.

Division of Women's Health, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA.

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http://dx.doi.org/10.1152/ajpendo.00361.2004DOI Listing
May 2005

Liver-specific protein-tyrosine phosphatase 1B (PTP1B) re-expression alters glucose homeostasis of PTP1B-/-mice.

J Biol Chem 2005 Apr 7;280(15):15038-46. Epub 2005 Feb 7.

Cancer Biology Program, Division of Hematology-Oncology, Department of Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts, 02215, USA.

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http://dx.doi.org/10.1074/jbc.M413240200DOI Listing
April 2005

Deletion of PPARgamma in adipose tissues of mice protects against high fat diet-induced obesity and insulin resistance.

Proc Natl Acad Sci U S A 2005 Apr 15;102(17):6207-12. Epub 2005 Apr 15.

Department of Molecular Physiology and Biophysics, Vanderbilt University Medical Center, Nashville, TN 37232, USA.

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http://dx.doi.org/10.1073/pnas.0306743102DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC556131PMC
April 2005

Recombinant methionyl human leptin administration activates signal transducer and activator of transcription 3 signaling in peripheral blood mononuclear cells in vivo and regulates soluble tumor necrosis factor-alpha receptor levels in humans with relative leptin deficiency.

J Clin Endocrinol Metab 2005 Mar 21;90(3):1625-31. Epub 2004 Dec 21.

D.Sc., Division of Endocrinology, Diabetes, and Metabolism, Beth Israel Deaconess Medical Center, Harvard Medical School, 330 Brookline Avenue, ST 816, Boston, Massachusetts 02215, USA.

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http://dx.doi.org/10.1210/jc.2004-1823DOI Listing
March 2005

Insulin hypersensitivity and resistance to streptozotocin-induced diabetes in mice lacking PTEN in adipose tissue.

Mol Cell Biol 2005 Mar;25(6):2498-510

Department of Pediatrics, Division of Neonatology, David Geffen School of Medicine at UCLA, Los Angeles, California 90095, USA.

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http://mcb.asm.org/cgi/doi/10.1128/MCB.25.6.2498-2510.2005
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http://dx.doi.org/10.1128/MCB.25.6.2498-2510.2005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1061603PMC
March 2005

Coordinated regulation of insulin signaling by the protein tyrosine phosphatases PTP1B and TCPTP.

Mol Cell Biol 2005 Jan;25(2):819-29

Department of Biochemistry and Molecular Biology, P.O. Box 13D, Monash University, Victoria 3800, Australia.

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http://dx.doi.org/10.1128/MCB.25.2.819-829.2005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC543412PMC
January 2005

AMP-activated protein kinase: ancient energy gauge provides clues to modern understanding of metabolism.

Cell Metab 2005 Jan;1(1):15-25

Division of Endocrinology, Diabetes and Metabolism, Beth Israel Deaconess Medical Center and Department of Medicine, Harvard Medical School, Boston, Massachusetts 02215, USA.

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http://dx.doi.org/10.1016/j.cmet.2004.12.003DOI Listing
January 2005

GLUT4 glucose transporter deficiency increases hepatic lipid production and peripheral lipid utilization.

J Clin Invest 2004 Dec;114(11):1666-75

Division of Endocrinology, Diabetes and Metabolism, Department of Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts, USA.

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http://dx.doi.org/10.1172/JCI21341DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC529279PMC
December 2004