Publications by authors named "Baohua Luo"

5 Publications

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Intestinal microbiota: A potential target for enhancing the antitumor efficacy and reducing the toxicity of immune checkpoint inhibitors.

Cancer Lett 2021 Jul 14;509:53-62. Epub 2021 Apr 14.

Division of Cancer Biology, Laboratory Animal Center, The Fourth Military Medical University, Xi'an, Shaanxi, 710032, China. Electronic address:

Accumulating evidence suggests that the intestinal microbiota is associated with the antitumor efficacy of immune checkpoint inhibitors (ICIs) and the occurrence of immune-related adverse events (irAEs) following ICI treatment. However, the mechanisms underlying these interactions remain unclear. Recent technological advances have allowed more extensive investigation into the interplay between the intestinal microbiota and the tumor immune microenvironment. Breakthroughs by two research groups revealed that Bifidobacterium enhanced the efficacy of ICIs via the stimulator of interferon genes (STING) and adenosine 2A receptor (AR) signaling pathways, highlighting the molecular mechanisms through which the intestinal microbiota modulates immunotherapy. In this review, we summarize recent findings related to the potential role and mechanisms of the gut microbiota in ICI therapy, available microbiota-targeting strategies, and ongoing clinical trials. Further we discuss the associated challenges that remain in this field of research. The current review aims to evaluate the potential of the intestinal microbiota in maximizing the antitumor efficacy of ICIs while minimizing their toxic effects and guiding the development of more specific treatment regimens.
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http://dx.doi.org/10.1016/j.canlet.2021.04.001DOI Listing
July 2021

Corrigendum to 'The lumbar autonomic nerves in male: A few anatomical insights into anterior lumbar interbody fusion' [The Spine Journal 20/12 (2002) p2006-2013].

Spine J 2021 Feb 14;21(2):355-356. Epub 2020 Nov 14.

Department of Orthopedics, The Third Affiliated Hospital of Southern Medical University, No. 183, Zhongshan Rd West, Guangzhou 510630, China. Electronic address:

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http://dx.doi.org/10.1016/j.spinee.2020.10.020DOI Listing
February 2021

The lumbar autonomic nerves in males: a few anatomical insights into anterior lumbar interbody fusion.

Spine J 2020 12 25;20(12):2006-2013. Epub 2020 Jul 25.

Department of Orthopedics, The Third Affiliated Hospital of Southern Medical University, No. 183, Zhongshan Rd West, Guangzhou 510630, China. Electronic address:

Background Context: Lumbar autonomic nerve injury is an underappreciated complication of anterior lumbar spinal surgery. A detailed description of lumbar autonomic nerve anatomy would be helpful for surgeons to minimize the risk of this complication.

Purpose: This study was designed to investigate the anatomical characteristics of lumbar autonomic nerves and provide a better understanding of these nerves for anterior lumbar spinal surgery.

Study Design: A dissection-based study of 10 embalmed male cadavers.

Methods: The lumbar autonomic nerves from 10 embalmed male cadavers were dissected in this study. The position of the lumbar sympathetic trunks was recorded. Distance between the initial sites of the lumbar splanchnic nerves (LSNs) and the corresponding lumbar vertebral inferior endplate, distance between the ipsilateral and adjacent LSNs, angles formed by the LSNs and the vertical axis were measured. This study has been supported by grants from Science and Technology Planning Project of Guangdong Province (CN) (Grant No. 2017B020210010) without potential conflict of interest-associated biases in the text of the paper.

Results: In this study, a total of 72 LSNs were identified in the 10 human cadavers. On average, the investigation found that the initial sites of the first, second, third, and fourth LSNs were 9 mm distal, 5 mm distal, 9 mm proximal, and 9 mm distal to the inferior endplates of the L1, L2, L3, and L4 vertebrae, respectively, with variations from 6 to 11 mm for each nerve among specimens. There was no significant difference in the angle between each lumbar splanchnic nerve and the vertical axis (H=2.461, p=.482), with an angle of approximately 50°±6°. The distance between the first and the second LSNs, the second and the third LSNs, or the third and the fourth LSNs were 24±6 mm, 22±8 mm, and 55±11 mm, respectively. The bilateral lumbar sympathetic trunks (N=57, 95%) were more likely to be located in the first third of the sagittal plane at the level of the L2/3, L3/4, and L4/5 intervertebral discs.

Conclusions: The study found the same number and parallel courses of LSNs on each side, and on both the left and right side, the distance between the third and the fourth LSNs was much larger than the distance between the other two adjacent LSNs. The initial sites of 80.6% (n=58) of LSNs were superior to the inferior endplate of the L3 vertebra. Improved knowledge of lumbar autonomic nerve anatomy may be of great significance in reducing complications and improving surgical safety.
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http://dx.doi.org/10.1016/j.spinee.2020.07.015DOI Listing
December 2020

Ultrabroad supercontinuum generated from a highly nonlinear Ge-Sb-Se fiber.

Opt Lett 2016 Jul;41(14):3201-4

We report the fabrication of a novel high nonlinear fiber made of Ge-Sb-Se chalcogenide glasses with high numerical aperture (∼1.0), where the core and the cladding glasses consist of Ge15Sb25Se60 and Ge15Sb20Se65 (mol. %), respectively. The nonlinear refractive index (n2) of the core glass is 19×10-18  m2/W at 1.55 μm, and its laser-induced damage threshold under irradiation of 3.0 μm fs laser is approximately 3674  GW/cm2. By pumping a 20-cm-long fiber with a core diameter of 23 μm using 150 fs pulses at 6.0 μm, supercontinuum spanning from ∼1.8 to ∼14  μm was generated.
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http://dx.doi.org/10.1364/OL.41.003201DOI Listing
July 2016

Acupuncture for Pain Management in Cancer: A Systematic Review and Meta-Analysis.

Evid Based Complement Alternat Med 2016 10;2016:1720239. Epub 2016 Feb 10.

The Second Clinical Medical School, Guangzhou University of Chinese Medicine, Guangzhou 510405, China.

Objective. To evaluate the effectiveness and safety of acupuncture for cancer-related pain. Methods. A systematic review of literatures published from database inception to February 2015 was conducted in eight databases. RCTs involving acupuncture for treatment of cancer-related pain were identified. Two researchers independently performed article selection, data extraction, and quality assessment of data. Results. 1,639 participants in twenty RCTs were analyzed. All selected RCTs were associated with high risk of bias. Meta-analysis indicated that acupuncture alone did not have superior pain-relieving effects as compared with conventional drug therapy. However, as compared with the drug therapy alone, acupuncture plus drug therapy resulted in increased pain remission rate, shorter onset time of pain relief, longer pain-free duration, and better quality of life without serious adverse effects. However, GRADE analysis revealed that the quality of all outcomes about acupuncture plus drug therapy was very low. Conclusions. Acupuncture plus drug therapy is more effective than conventional drug therapy alone for cancer-related pain. However, multicenter high-quality RCTs with larger sample sizes are needed to provide stronger evidence for the effectiveness of acupuncture in cancer-related pain due to the low data quality of the studies included in the current meta-analysis.
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http://dx.doi.org/10.1155/2016/1720239DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4764722PMC
March 2016