Publications by authors named "Bambang Sasongko Noegroho"

9 Publications

  • Page 1 of 1

Validation of FGSI Scores in Predicting Fournier Gangrene in Tertiary Hospital.

Res Rep Urol 2021 9;13:341-346. Epub 2021 Jun 9.

Urology Department, Hasan Sadikin Academic Medical Center, Universitas Padjajaran Bandung, Barat, Indonesia.

Background And Aim: Fournier gangrene (FG) is a necrotizing fasciitis of perineal and/or genital regions that may progressively spread; necrotic tissue may cause morbidity and mortality related to sepsis and multi-organ dysfunction. Surgical intervention required for patients with Fournier gangrene may vary according to the severity of the infection. A Fournier Gangrene Severity Index (FGSI) has been devised to assess the risk of mortality in patients with Fournier gangrene. The aim of this study was to validate the implementation of the FGSI in predicting mortality of FG patients in our hospital.

Methods: A retrospective study was performed on all patients with Fournier gangrene admitted and treated in Hasan Sadikin General Hospital during 2015-2019. Data were collected from the medical records of the emergency room and outpatient clinics. Sociodemographic variables, preexisting comorbidities, outcome, management, and FGSI score were included as variables.

Results: In this study, 83 patients were included from the period 2015-2019, divided into two groups. From the Charlson Comorbidity Index, we found the first group average score was 2.5 (0-9), and the second group this was 2 (1-8). From the FGSI, in the first group, we found the average score was 5.5 (2-15), and the average was 14 (10-19) in the second group, which is significantly higher than the first group (p = 0.001).

Conclusion: We find that the FGSI score system is a good tool for predicting severity of the disease and mortality risk of the patients, which is consistent with findings in other studies.
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http://dx.doi.org/10.2147/RRU.S309145DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8200139PMC
June 2021

Factors Affecting Survival Outcome After Percutaneous Nephrostomy as Palliative Urinary Diversion in Obstructive Uropathy due to Advance Cervical Cancer Patients.

Asian Pac J Cancer Prev 2021 Apr 1;22(4):1211-1216. Epub 2021 Apr 1.

Department of Urology, Faculty of Medicine Universitas Padjadjaran/Hasan Sadikin General Hospital, Bandung, Indonesia.

Introduction: Cervical cancer is the 3rd most common cancer in women. In late stages, obstructive uropathy due to mass infiltration is common and the mainstay of treatment for this condition is palliative urinary diversion through percutaneous nephrostomy. Nevertheless, complications due to nephrostomy may have adverse effects on some patients. Further study is necessary to determine whether nephrostomy is suitable for all cervical cancer patients with obstructive uropathy. This study aims to identify the determinants of survival rate of cervical cancer patients undergoing nephrostomy for obstructive uropathy and determine the group of cervical cancer patients that would benefit the most from nephrostomy.

Methods: Data were obtained from medical records of cervical cancer patients in Hasan Sadikin Central Public Hospital from January 2018 to December 2019. Log-rank analysis was performed to assess the survival rate of patients based on clinical conditions (age, metastasis, and ECOG performance status) and initial laboratory results (hemoglobin, leukocyte, thrombocyte and blood acidity).

Results: A total of 163 cases were identified from the medical records, with a median survival of 5(1-17) months. The results of the analysis showed that the survival rates of cervical cancer patients undergoing nephrostomy were significantly affected by age (p = 0.0001), metastasis (p = 0.0001), and ECOG performance status (p = 0.0001), while laboratory findings were not significant factors affecting survival (pHb=0.501; pLeu=0.634; pTr=0.077; pBGA=0.687).

Conclusion: The survival after nephrostomy in advanced cervical cancer patients is largely affected by age, metastasis, and performance status. The choices of doing nephrostomy in those patients should be considering those factors to maximize the benefit over the risk of complications.
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http://dx.doi.org/10.31557/APJCP.2021.22.4.1211DOI Listing
April 2021

Inverted mucosa and avulsion ureteral injury in ureteroscopic procedure: A very rare complication of a common procedure in urology.

Urol Case Rep 2021 Jul 12;37:101605. Epub 2021 Feb 12.

Department of Urology, Faculty of Medicine, Padjadjaran University, Hasan Sadikin General Hospital, Jl. Pasteur no. 38, Bandung, West Java, 40161, Indonesia.

An avulsion is very rare and the most serious complication that may occur during ureteroscopy in 0.06-0.45% of patients during the ureteral stone procedure. A sixty years-old female with a small stone in the upper third of the right ureter with high-grade hydronephrosis and underwent a ureteroscopy procedure. During withdrawal of the scope, the ureter was brought out in urethral meatus, with inverted fashion, nearly the whole length of the ureter was avulsed out. A nephrectomy of the right kidney was then performed. Knowledge about signs of the ureteral avulsion, pitfalls when to stop, and treatments is really important.
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http://dx.doi.org/10.1016/j.eucr.2021.101605DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7905439PMC
July 2021

Polymorphism of II, 1, and SNP 12 Estrogen Receptor 1 (ESR1) in Hipospadias Patients at Tertiary Hospital Center.

Res Rep Urol 2021 25;13:105-110. Epub 2021 Feb 25.

Department of Molecular Genetic Laboratory Universitas Padjadjaran, Bandung City, West Java Province, Indonesia.

Introduction: The prevalence of hypospadias ranges between 1: 250 to 300 per live birth. Estrogen exposure has been associated with the increasing incidence of hypospadias in humans and a significant relationship between Estrogen Receptor 1 (ESR1) polymorphisms and hypospadias was determined from the previous study. This study aims to determine the proportion of ESR1 polymorphism.

Methods: This was a descriptive study aimed to find the incidence of ESR1 gene polymorphism in hypospadias patients visiting the Urology Outpatient Unit of the Hasan Sadikin Bandung Hospital who will undergo hypospadias surgery. Deoxyribonucleic acid (DNA) was performed using foreskin of hypospadias patient during the surgery then being extracted and will be analyzed using polymerase chain reaction (PCR) sequencing.

Results: Thirty eight samples of hypospadias were identified, 5 samples were unable to sequence and 33 samples were successfully sequenced using the PCR method. The Pvull ESR1 gene was dominated by the T allele which is a wild-type allele and the genotype containing the T allele, namely TT + TC (57,2%). Normal genotype (TT) were more frequent in distal hypospadias, and Heterozygous polymorphisms (TC) was higher in proximal hypospadias. The ESR1 Xba1 gene polymorphism was dominated by the A allele which is a wild-type allele and the AA + AG genotype (76,1%). Normal genotype (AA) was more frequent in distal hypospadias, and both heterozygous hypospadias (AG) and homozygous hypospadias (GG) were found only in proximal hypospadias. The ESR1 SNP 12 gene polymorphisms were found in the combination of genotypes that played a role, namely GA + AA (81%) and the G allele which is a wild-type allele. Heterozygous polymorphisms (GA) was the most finding genotype and more frequent in proximal hypospadias.

Conclusion: ESR1 gene polymorphisms (PvuII, XbaI, and SNP 12) were found in hypospadias patients. ESR1 polymorphisms may correlate with the severity of hypospadias. Further research with a larger sample and better hypospadias grouping is needed to confirm.
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http://dx.doi.org/10.2147/RRU.S296941DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7920578PMC
February 2021

Penile strangulation injury by metallic ring: A study of 4 cases.

Int J Surg Case Rep 2021 Mar 1;80:105609. Epub 2021 Feb 1.

Department of Urology, Faculty of Medicine Universitas Padjadjaran, Hasan Sadikin Hospital, Indonesia.

Penile strangulation by metallic ring is an emergency situation which requires urgent management. Strangulation of the penis usually performed in order to increase sexual performance or because underlying mental disorder or paraphilia. It is an uncommon urological emergency, if not treated as soon as possible it can lead to complications such as gangrene and amputation of the penis. There is no standard of care that has been found to be superior, with each case managed individually according to its clinical findings and operative settings. In this study, we present four cases of penile strangulation in last two years in a tertiary care hospital.
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http://dx.doi.org/10.1016/j.ijscr.2021.01.103DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7898070PMC
March 2021

Intratesticular Human Adipose-Derived Stem Cell (hADSC) Transplantation Decreased Oxidative Stress in Testicular Torsion Model of Wistar Rat.

Res Rep Urol 2021 6;13:1-8. Epub 2021 Jan 6.

Department of Urology, Faculty of Medicine Universitas Padjadjaran, Hasan Sadikin General Hospital, Banding, Indonesia.

Introduction: Testicular torsion is a sudden rotation of the testis towards its axis, which causes the twisting of the spermatic cord. Post-detorsion reperfusion will cause inflammation and trigger oxidative stress, which generates reactive oxygen species (ROS). Malondialdehyde (MDA) is an organic compound formed from ROS frequently used as an oxidative stress biomarker during ischemia and ischemia-reperfusion injury. In some organs, stem cell administration on the damaged organ is essential in preventing cellular damage and death. This study aimed to learn about the effect of hADSC administration on an ischemia-reperfusion injury.

Material And Methods: A total of 22 Wistar rats divided into 5 groups, two groups each consist of 5 male Wistar rats with testicular torsion model without hADSC therapy (group I), while 2 other groups consist of 5 rats with testicular torsion model were given 1.0×10 cells intratesticular hADSC injection 30 minutes after testicular detorsion (group II). Both groups were euthanized at 1 and 4 weeks of observation. The last group consists of 2 rats without any treatment or model (negative control group). Following euthanasia, testicular tissue was harvested for MDA expression measurement using ELISA and histopathological examination. Statistical analysis using an one way ANOVA was done with SPSS version 21.0.

Results: The result of MDA examination using the ELISA method has shown a concentration difference between group I (control) and group II (hADSC treatment). Testicular MDA concentration in the treatment group was significantly lower on the 1st and 4th week of observation (p=0.000, p=0.016). Post hoc analysis showed no statistically different between therapy and healthy group (p=0.972). On histopathological examination, Johnsen score in the treatment group was significantly higher on the 4th week of observation (p=0.044). Post hoc analysis showed no statistically different between therapy and healthy group (p=0.195).

Conclusion: Intratesticular hADSC administration can inhibit ROS formation due to ischemia-reperfusion injury in testicular tissue after testicular detorsion in Wistar rats.
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http://dx.doi.org/10.2147/RRU.S283861DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7797314PMC
January 2021

Reno-duodenal fistula as a rare complication of percutaneous nephrostomy: A case report.

Urol Case Rep 2021 Mar 21;35:101547. Epub 2020 Dec 21.

Department of Urology, Faculty of Medicine Padjadjaran University, Hasan Sadikin Hospital Bandung, Indonesia.

Renoduodenal fistula is a rare condition where a pathological tract is formed between the kidney and duodenum. This condition is caused by various etiologies, such as tuberculosis, malignancy, percutaneous nephrostomy procedure, cryoablation procedure in malignancy, and chronic infection. In this case, we report a case renoduodenal fistula caused by large staghorn calculus, precipitated by a previous history of trauma. Renoduodenal fistula is a rare condition that often presents without symptoms. This condition can be caused by chronic infection of the kidney, and one of the etiology is an infected large staghorn calculus.
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http://dx.doi.org/10.1016/j.eucr.2020.101547DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7770530PMC
March 2021

Giant vaginal stone as a complication of long-term urethrovaginal fistula: A case report.

Urol Case Rep 2021 Jan 11;34:101491. Epub 2020 Nov 11.

Department of Urology, Faculty of Medicine Padjadjaran University, Hasan Sadikin Hospital Bandung, Indonesia.

Case Presentation: A case of a 57 years old woman came with the chief complaint of urinary incontinence since 20 years ago. After labor, she complained of urinary incontinence and left untreated. Physical examination and urethrocystoscopy revealed vaginal stone sized 90 × 70 mm and urethrovaginal fistula. We performed hysterectomy and vaginal stone removal, continued with fistula closure and vaginal repair. Up to 2 months follow up, no sign of urinary leakage and incontinence was found.

Conclusion: Vaginal stone is a rare Case that might be present in a case of long term urethrovaginal fistula with neglected contraceptive device.
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http://dx.doi.org/10.1016/j.eucr.2020.101491DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7701185PMC
January 2021

The effect of intravenous human adipose-derived stem cells (hADSC) on transforming growth factor β1 (TGF-β1), collagen type 1, and kidney histopathological features in the unilateral ureteropelvic junction obstruction model of wistar rats.

Turk J Urol 2020 05 1;46(3):236-242. Epub 2020 May 1.

Department of Urology, Faculty of Medicine Universitas Padjadjaran, Dr. Hasan Sadikin General Hospital, Indonesia.

Objective: The fibrotic process of kidney resulting in glomerulosclerosis was found in patients with ureteropelvic junction obstruction (UPJO) who underwent renal biopsy during pyeloplasty. Transforming growth factor β1 (TGF-β1) plays a role in collagen accumulation, resulting in fibrosis. Adipose tissue-derived stem cells (ADSCs) have an anti-apoptotic effect on target cells and enhance the kidney function recovery. We will further investigate the use of ADSC in the prevention of kidney fibrosis in the unilateral UPJO model of Wistar rats.

Material And Methods: A total of twenty-two 12-week-old Wistar rats were divided into three groups. We made the UPJO models using nylon 6-0 inside the left ureter and tied the ureter with nylon 6-0, creating partial ureteral obstruction. The treatment group was then injected with 1.0 × 10 cells of human ADSC via the tail vein of rats. All rats were euthanized after 2 and 4 weeks of treatment. The left kidney used hematoxylin-eosin for histopathological examination. Statistical analysis using one-way analysis of variance (ANOVA) was done with SPSS version 21.0.

Results: TGF-β1 concentration in the treatment group was significantly lower in the 4 week of observation (p4=0.0001), as well as collagen type 1, which was also significantly lower in the 4 week (p4=0.0001). There was a significant difference in the glomerulus count between the control group and the human ADSC (hADSC) group therapy in week 2 and week 4 (p2=0.0001 and p4=0.026).

Conclusion: Administration of hADSC therapy reduces TGF-β1 and collagen type 1 levels and then improves the histopathological features in the process of renal fibrosis in the UPJO model.
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http://dx.doi.org/10.5152/tud.2020.20024DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7219970PMC
May 2020