Publications by authors named "Balram Chowbay"

81Publications

Genetic association study of exfoliation syndrome identifies a protective rare variant at LOXL1 and five new susceptibility loci.

Authors:
Tin Aung Mineo Ozaki Mei Chin Lee Ursula Schlötzer-Schrehardt Gudmar Thorleifsson Takanori Mizoguchi Robert P Igo Aravind Haripriya Susan E Williams Yury S Astakhov Andrew C Orr Kathryn P Burdon Satoko Nakano Kazuhiko Mori Khaled Abu-Amero Michael Hauser Zheng Li Gopalakrishnan Prakadeeswari Jessica N Cooke Bailey Alina Popa Cherecheanu Jae H Kang Sarah Nelson Ken Hayashi Shin-Ichi Manabe Shigeyasu Kazama Tomasz Zarnowski Kenji Inoue Murat Irkec Miguel Coca-Prados Kazuhisa Sugiyama Irma Järvelä Patricio Schlottmann S Fabian Lerner Hasnaa Lamari Yildirim Nilgün Mukharram Bikbov Ki Ho Park Soon Cheol Cha Kenji Yamashiro Juan C Zenteno Jost B Jonas Rajesh S Kumar Shamira A Perera Anita S Y Chan Nino Kobakhidze Ronnie George Lingam Vijaya Tan Do Deepak P Edward Lourdes de Juan Marcos Mohammad Pakravan Sasan Moghimi Ryuichi Ideta Daniella Bach-Holm Per Kappelgaard Barbara Wirostko Samuel Thomas Daniel Gaston Karen Bedard Wenda L Greer Zhenglin Yang Xueyi Chen Lulin Huang Jinghong Sang Hongyan Jia Liyun Jia Chunyan Qiao Hui Zhang Xuyang Liu Bowen Zhao Ya-Xing Wang Liang Xu Stéphanie Leruez Pascal Reynier George Chichua Sergo Tabagari Steffen Uebe Matthias Zenkel Daniel Berner Georg Mossböck Nicole Weisschuh Ursula Hoja Ulrich-Christoph Welge-Luessen Christian Mardin Panayiota Founti Anthi Chatzikyriakidou Theofanis Pappas Eleftherios Anastasopoulos Alexandros Lambropoulos Arkasubhra Ghosh Rohit Shetty Natalia Porporato Vijayan Saravanan Rengaraj Venkatesh Chandrashekaran Shivkumar Narendran Kalpana Sripriya Sarangapani Mozhgan R Kanavi Afsaneh Naderi Beni Shahin Yazdani Alireza Lashay Homa Naderifar Nassim Khatibi Antonio Fea Carlo Lavia Laura Dallorto Teresa Rolle Paolo Frezzotti Daniela Paoli Erika Salvi Paolo Manunta Yosai Mori Kazunori Miyata Tomomi Higashide Etsuo Chihara Satoshi Ishiko Akitoshi Yoshida Masahide Yanagi Yoshiaki Kiuchi Tsutomu Ohashi Toshiya Sakurai Takako Sugimoto Hideki Chuman Makoto Aihara Masaru Inatani Masahiro Miyake Norimoto Gotoh Fumihiko Matsuda Nagahisa Yoshimura Yoko Ikeda Morio Ueno Chie Sotozono Jin Wook Jeoung Min Sagong Kyu Hyung Park Jeeyun Ahn Marisa Cruz-Aguilar Sidi M Ezzouhairi Abderrahman Rafei Yaan Fun Chong Xiao Yu Ng Shuang Ru Goh Yueming Chen Victor H K Yong Muhammad Imran Khan Olusola O Olawoye Adeyinka O Ashaye Idakwo Ugbede Adeola Onakoya Nkiru Kizor-Akaraiwe Chaiwat Teekhasaenee Yanin Suwan Wasu Supakontanasan Suhanya Okeke Nkechi J Uche Ifeoma Asimadu Humaira Ayub Farah Akhtar Ewa Kosior-Jarecka Urszula Lukasik Ignacio Lischinsky Vania Castro Rodolfo Perez Grossmann Gordana Sunaric Megevand Sylvain Roy Edward Dervan Eoin Silke Aparna Rao Priti Sahay Pablo Fornero Osvaldo Cuello Delia Sivori Tamara Zompa Richard A Mills Emmanuelle Souzeau Paul Mitchell Jie Jin Wang Alex W Hewitt Michael Coote Jonathan G Crowston Sergei Y Astakhov Eugeny L Akopov Anton Emelyanov Vera Vysochinskaya Gyulli Kazakbaeva Rinat Fayzrakhmanov Saleh A Al-Obeidan Ohoud Owaidhah Leyla Ali Aljasim Balram Chowbay Jia Nee Foo Raphael Q Soh Kar Seng Sim Zhicheng Xie Augustine W O Cheong Shi Qi Mok Hui Meng Soo Xiao Yin Chen Su Qin Peh Khai Koon Heng Rahat Husain Su-Ling Ho Axel M Hillmer Ching-Yu Cheng Francisco A Escudero-Domínguez Rogelio González-Sarmiento Frederico Martinon-Torres Antonio Salas Kessara Pathanapitoon Linda Hansapinyo Boonsong Wanichwecharugruang Naris Kitnarong Anavaj Sakuntabhai Hip X Nguyn Giang T T Nguyn Trình V Nguyn Werner Zenz Alexander Binder Daniela S Klobassa Martin L Hibberd Sonia Davila Stefan Herms Markus M Nöthen Susanne Moebus Robyn M Rautenbach Ari Ziskind Trevor R Carmichael Michele Ramsay Lydia Álvarez Montserrat García Héctor González-Iglesias Pedro P Rodríguez-Calvo Luis Fernández-Vega Cueto Çilingir Oguz Nevbahar Tamcelik Eray Atalay Bilge Batu Dilek Aktas Burcu Kasım M Roy Wilson Anne L Coleman Yutao Liu Pratap Challa Leon Herndon Rachel W Kuchtey John Kuchtey Karen Curtin Craig J Chaya Alan Crandall Linda M Zangwill Tien Yin Wong Masakazu Nakano Shigeru Kinoshita Anneke I den Hollander Eija Vesti John H Fingert Richard K Lee Arthur J Sit Bradford J Shingleton Ningli Wang Daniele Cusi Raheel Qamar Peter Kraft Margaret A Pericak-Vance Soumya Raychaudhuri Steffen Heegaard Tero Kivelä André Reis Friedrich E Kruse Robert N Weinreb Louis R Pasquale Jonathan L Haines Unnur Thorsteinsdottir Fridbert Jonasson R Rand Allingham Dan Milea Robert Ritch Toshiaki Kubota Kei Tashiro Eranga N Vithana Shazia Micheal Fotis Topouzis Jamie E Craig Michael Dubina Periasamy Sundaresan Kari Stefansson Janey L Wiggs Francesca Pasutto Chiea Chuen Khor

Nat Genet 2017 07 29;49(7):993-1004. Epub 2017 May 29.

Singapore Eye Research Institute, Singapore.

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http://dx.doi.org/10.1038/ng.3875DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6685441PMC
July 2017

Influence of the KDM4A rs586339 polymorphism on overall survival in Asian non-small-cell lung cancer patients.

Pharmacogenet Genomics 2017 03;27(3):120-123

aLaboratory of Clinical Pharmacology, Division of Medical Sciences, Humphrey Oei Institute of Cancer Research bNational Cancer Centre, Division of Medical Oncology cClinical Pharmacology, SingHealth dDepartment of Clinical Sciences, Duke-NUS Medical School, Singapore.

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http://dx.doi.org/10.1097/FPC.0000000000000266DOI Listing
March 2017

Metronomic chemotherapy: A relook at its basis and rationale.

Cancer Lett 2017 03 18;388:328-333. Epub 2016 Dec 18.

Division of Medical Oncology, National Cancer Centre, Singapore. Electronic address:

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http://dx.doi.org/10.1016/j.canlet.2016.12.013DOI Listing
March 2017

EGFR Mutation Subtypes Influence Survival Outcomes following First-Line Gefitinib Therapy in Advanced Asian NSCLC Patients.

J Thorac Oncol 2017 03 28;12(3):529-538. Epub 2016 Nov 28.

Clinical Pharmacology, SingHealth, Singapore; Laboratory of Clinical Pharmacology, Division of Medical Sciences, Humphrey Oei Institute of Cancer Research, National Cancer Centre, Singapore; Office of Clinical Sciences, Duke-National University of Singapore Medical School, Singapore. Electronic address:

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http://dx.doi.org/10.1016/j.jtho.2016.11.2225DOI Listing
March 2017

Pharmacogenetics of drug transporters in modulating imatinib disposition and treatment outcomes in chronic myeloid leukemia & gastrointestinal stromal tumor patients.

Pharmacogenomics 2016 Nov 2;17(17):1941-1955. Epub 2016 Nov 2.

Laboratory of Clinical Pharmacology, Division of Medical Sciences, Humphrey Oei Institute of Cancer Research, National Cancer Centre Singapore, Singapore.

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https://www.futuremedicine.com/doi/10.2217/pgs-2016-0124
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http://dx.doi.org/10.2217/pgs-2016-0124DOI Listing
November 2016

A Single Dose-Escalation Study to Evaluate the Safety and Pharmacokinetics of Orally Administered Des-Aspartate Angiotensin I in Healthy Subjects.

Drugs R D 2016 Dec;16(4):317-326

Department of Pharmacology, Yong Loo Lin School of Medicine, Block MD 3 Level 4 #04-01, 16 Medical Drive, Singapore, 117600, Singapore.

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http://dx.doi.org/10.1007/s40268-016-0143-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5114201PMC
December 2016

Pharmacogenetics of irinotecan, doxorubicin and docetaxel transporters in Asian and Caucasian cancer patients: a comparative review.

Drug Metab Rev 2016 11;48(4):502-540

a Clinical Pharmacology Laboratory, Division of Medical Sciences , Humphrey Oei Institute of Cancer Research , National Cancer Center Singapore , Singapore.

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http://dx.doi.org/10.1080/03602532.2016.1226896DOI Listing
November 2016

Corrigendum: a common variant mapping to CACNA1A is associated with susceptibility to exfoliation syndrome.

Authors:
Tin Aung Mineo Ozaki Takanori Mizoguchi R Rand Allingham Zheng Li Aravind Haripriya Satoko Nakano Steffen Uebe Jeffrey M Harder Anita S Y Chan Mei Chin Lee Kathryn P Burdon Yury S Astakhov Khaled K Abu-Amero Juan C Zenteno Yildirim Nilgün Tomasz Zarnowski Mohammad Pakravan Leen Abu Safieh Liyun Jia Ya Xing Wang Susan Williams Daniela Paoli Patricio G Schlottmann Lulin Huang Kar Seng Sim Jia Nee Foo Masakazu Nakano Yoko Ikeda Rajesh S Kumar Morio Ueno Shin-Ichi Manabe Ken Hayashi Shigeyasu Kazama Ryuichi Ideta Yosai Mori Kazunori Miyata Kazuhisa Sugiyama Tomomi Higashide Etsuo Chihara Kenji Inoue Satoshi Ishiko Akitoshi Yoshida Masahide Yanagi Yoshiaki Kiuchi Makoto Aihara Tsutomu Ohashi Toshiya Sakurai Takako Sugimoto Hideki Chuman Fumihiko Matsuda Kenji Yamashiro Norimoto Gotoh Masahiro Miyake Sergei Y Astakhov Essam A Osman Saleh A Al-Obeidan Ohoud Owaidhah Leyla Al-Jasim Sami Al Shahwan Rhys A Fogarty Paul Leo Yaz Yetkin Çilingir Oğuz Mozhgan Rezaei Kanavi Afsaneh Naderi Beni Shahin Yazdani Evgeny L Akopov Kai-Yee Toh Gareth R Howell Andrew C Orr Yufen Goh Wee Yang Meah Su Qin Peh Ewa Kosior-Jarecka Urszula Lukasik Mandy Krumbiegel Eranga N Vithana Tien Yin Wong Yutao Liu Allison E Ashley Koch Pratap Challa Robyn M Rautenbach David A Mackey Alex W Hewitt Paul Mitchell Jie Jin Wang Ari Ziskind Trevor Carmichael Rangappa Ramakrishnan Kalpana Narendran Rangaraj Venkatesh Saravanan Vijayan Peiquan Zhao Xueyi Chen Dalia Guadarrama-Vallejo Ching Yu Cheng Shamira A Perera Rahat Husain Su-Ling Ho Ulrich-Christoph Welge-Luessen Christian Mardin Ursula Schloetzer-Schrehardt Axel M Hillmer Stefan Herms Susanne Moebus Markus M Nöthen Nicole Weisschuh Rohit Shetty Arkasubhra Ghosh Yik Ying Teo Matthew A Brown Ignacio Lischinsky Jonathan G Crowston Michae Coote Bowen Zhao Jinghong Sang Nihong Zhang Qisheng You Vera Vysochinskaya Panayiota Founti Anthoula Chatzikyriakidou Alexandros Lambropoulos Eleftherios Anastasopoulos Anne L Coleman M Roy Wilson Douglas J Rhee Jae Hee Kang Inna May-Bolchakova Steffen Heegaard Kazuhiko Mori Wallace L M Alward Jost B Jonas Liang Xu Jeffrey M Liebmann Balram Chowbay Elke Schaeffeler Matthias Schwab Fabian Lerner Ningli Wang Zhenglin Yang Paolo Frezzotti Shigeru Kinoshita John H Fingert Masaru Inatani Kei Tashiro André Reis Deepak P Edward Louis R Pasquale Toshiaki Kubota Janey L Wiggs Francesca Pasutto Fotis Topouzis Michael Dubina Jamie E Craig Nagahisa Yoshimura Periasamy Sundaresan Simon W M John Robert Ritch Michael A Hauser Chiea-Chuen Khor

Nat Genet 2015 Jun;47(6):689

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http://dx.doi.org/10.1038/ng0615-689cDOI Listing
June 2015

Colchicine effectiveness in symptom and inflammation modification in knee osteoarthritis (COLKOA): study protocol for a randomized controlled trial.

Trials 2015 Apr 30;16:200. Epub 2015 Apr 30.

The Duke Molecular Physiology Institute and Division of Rheumatology, Department of Medicine, Duke University School of Medicine, Durham, NC, USA.

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http://dx.doi.org/10.1186/s13063-015-0726-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4434529PMC
April 2015

A common variant mapping to CACNA1A is associated with susceptibility to exfoliation syndrome.

Authors:
Tin Aung Mineo Ozaki Takanori Mizoguchi R Rand Allingham Zheng Li Aravind Haripriya Satoko Nakano Steffen Uebe Jeffrey M Harder Anita S Y Chan Mei Chin Lee Kathryn P Burdon Yury S Astakhov Khaled K Abu-Amero Juan C Zenteno Yildirim Nilgün Tomasz Zarnowski Mohammad Pakravan Leen Abu Safieh Liyun Jia Ya Xing Wang Susan Williams Daniela Paoli Patricio G Schlottmann Lulin Huang Kar Seng Sim Jia Nee Foo Masakazu Nakano Yoko Ikeda Rajesh S Kumar Morio Ueno Shin-ichi Manabe Ken Hayashi Shigeyasu Kazama Ryuichi Ideta Yosai Mori Kazunori Miyata Kazuhisa Sugiyama Tomomi Higashide Etsuo Chihara Kenji Inoue Satoshi Ishiko Akitoshi Yoshida Masahide Yanagi Yoshiaki Kiuchi Makoto Aihara Tsutomu Ohashi Toshiya Sakurai Takako Sugimoto Hideki Chuman Fumihiko Matsuda Kenji Yamashiro Norimoto Gotoh Masahiro Miyake Sergei Y Astakhov Essam A Osman Saleh A Al-Obeidan Ohoud Owaidhah Leyla Al-Jasim Sami Al Shahwan Rhys A Fogarty Paul Leo Yaz Yetkin Çilingir Oğuz Mozhgan Rezaei Kanavi Afsaneh Nederi Beni Shahin Yazdani Evgeny L Akopov Kai-Yee Toh Gareth R Howell Andrew C Orr Yufen Goh Wee Yang Meah Su Qin Peh Ewa Kosior-Jarecka Urszula Lukasik Mandy Krumbiegel Eranga N Vithana Tien Yin Wong Yutao Liu Allison E Ashley Koch Pratap Challa Robyn M Rautenbach David A Mackey Alex W Hewitt Paul Mitchell Jie Jin Wang Ari Ziskind Trevor Carmichael Rangappa Ramakrishnan Kalpana Narendran Rangaraj Venkatesh Saravanan Vijayan Peiquan Zhao Xueyi Chen Dalia Guadarrama-Vallejo Ching Yu Cheng Shamira A Perera Rahat Husain Su-Ling Ho Ulrich-Christoph Welge-Luessen Christian Mardin Ursula Schloetzer-Schrehardt Axel M Hillmer Stefan Herms Susanne Moebus Markus M Nöthen Nicole Weisschuh Rohit Shetty Arkasubhra Ghosh Yik Ying Teo Matthew A Brown Ignacio Lischinsky Jonathan G Crowston Michael Coote Bowen Zhao Jinghong Sang Nihong Zhang Qisheng You Vera Vysochinskaya Panayiota Founti Anthoula Chatzikyriakidou Alexandros Lambropoulos Eleftherios Anastasopoulos Anne L Coleman M Roy Wilson Douglas J Rhee Jae Hee Kang Inna May-Bolchakova Steffen Heegaard Kazuhiko Mori Wallace L M Alward Jost B Jonas Liang Xu Jeffrey M Liebmann Balram Chowbay Elke Schaeffeler Matthias Schwab Fabian Lerner Ningli Wang Zhenglin Yang Paolo Frezzotti Shigeru Kinoshita John H Fingert Masaru Inatani Kei Tashiro André Reis Deepak P Edward Louis R Pasquale Toshiaki Kubota Janey L Wiggs Francesca Pasutto Fotis Topouzis Michael Dubina Jamie E Craig Nagahisa Yoshimura Periasamy Sundaresan Simon W M John Robert Ritch Michael A Hauser Chiea-Chuen Khor

Nat Genet 2015 Apr 23;47(4):387-92. Epub 2015 Feb 23.

1] Singapore Eye Research Institute, Singapore. [2] Department of Ophthalmology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore. [3] Division of Human Genetics, Genome Institute of Singapore, Singapore.

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http://dx.doi.org/10.1038/ng.3226DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4605818PMC
April 2015

Pharmacogenetic effects of regulatory nuclear receptors (PXR, CAR, RXRα and HNF4α) on docetaxel disposition in Chinese nasopharyngeal cancer patients.

Eur J Clin Pharmacol 2014 Feb 6;70(2):155-66. Epub 2013 Nov 6.

Department of Pharmacology, Yong Loo Lin School of Medicine, National University of Singapore, 10 Medical Drive, Singapore, Singapore, 117597.

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http://dx.doi.org/10.1007/s00228-013-1596-3DOI Listing
February 2014

Pharmacogenetics and its relevance to clinical practice.

Ann Acad Med Singap 2013 Sep;42(9):429-31

Laboratory of Clinical Pharmacology, Humphrey Oei Institute of Cancer Research, National Cancer Centre, Singapore.

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September 2013

SLC22A1-ABCB1 haplotype profiles predict imatinib pharmacokinetics in Asian patients with chronic myeloid leukemia.

PLoS One 2012 18;7(12):e51771. Epub 2012 Dec 18.

Laboratory of Clinical Pharmacology, Division of Medical Sciences, Humphrey Oei Institute of Cancer Research, National Cancer Centre Singapore, Singapore.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0051771PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3525665PMC
June 2013

Genetic variations of NR2A1 in Asian populations: implications in pharmacogenetics studies.

Drug Metab Pharmacokinet 2013 25;28(3):278-88. Epub 2012 Dec 25.

Laboratory of Clinical Pharmacology, Division of Medical Sciences, Humphrey Oei Institute of Cancer Research, National Cancer Centre, Singapore.

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http://dx.doi.org/10.2133/dmpk.dmpk-12-sh-114DOI Listing
January 2014

Genetic variations of NR1I3 and NR2B1 in Asian populations.

Drug Metab Pharmacokinet 2013 24;28(2):169-76. Epub 2012 Jul 24.

Laboratory of Clinical Pharmacology, Division of Medical Sciences, Humphrey Oei Institute of Cancer Research, National Cancer Centre, Singapore, Singapore.

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http://dx.doi.org/10.2133/dmpk.dmpk-12-sc-060DOI Listing
July 2014

Phase I pharmacokinetic study of chronomodulated dose-intensified combination of capecitabine and oxaliplatin (XELOX) in metastatic colorectal cancer.

Cancer Chemother Pharmacol 2012 Jul 31;70(1):141-50. Epub 2012 May 31.

Department of Medical Oncology, National Cancer Centre, 11 Hospital Drive, Singapore 169610, Singapore.

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http://link.springer.com/10.1007/s00280-012-1895-x
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http://dx.doi.org/10.1007/s00280-012-1895-xDOI Listing
July 2012

Influence of SLCO1B3 haplotype-tag SNPs on docetaxel disposition in Chinese nasopharyngeal cancer patients.

Br J Clin Pharmacol 2012 Apr;73(4):606-18

Laboratory of Clinical Pharmacology, Division of Medical Sciences, Humphrey Oei Institute of Cancer Research, National Cancer Centre, 11 Hospital Drive, Singapore.

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http://dx.doi.org/10.1111/j.1365-2125.2011.04123.xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3376437PMC
April 2012

Impact of CYP2D6, CYP3A5, CYP2C9 and CYP2C19 polymorphisms on tamoxifen pharmacokinetics in Asian breast cancer patients.

Br J Clin Pharmacol 2011 May;71(5):737-50

Laboratory of Clinical Pharmacology, Division of Medical Sciences, Humphrey Oei Institute of Cancer Research, National Cancer Centre, Singapore.

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http://dx.doi.org/10.1111/j.1365-2125.2011.03905.xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3093079PMC
May 2011

The effects of CYP3A4, CYP3A5, ABCB1, ABCC2, ABCG2 and SLCO1B3 single nucleotide polymorphisms on the pharmacokinetics and pharmacodynamics of docetaxel in nasopharyngeal carcinoma patients.

Cancer Chemother Pharmacol 2011 Jun 6;67(6):1471-8. Epub 2011 Apr 6.

Department of Pharmacology, Yong Loo Lin School of Medicine, National University of Singapore, 10 Medical Drive, Singapore 117597, Singapore.

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http://dx.doi.org/10.1007/s00280-011-1625-9DOI Listing
June 2011

Secreted protein profile from HepG2 cells incubated by S(-) and R(+) enantiomers of chiral drug warfarin - An analysis in cell-based system and clinical samples.

Proteomics Clin Appl 2010 Nov;4(10-11):808-15

School of Chemical and Biomedical Engineering, College of Engineering, Nanyang Technological University, Singapore, Singapore.

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http://dx.doi.org/10.1002/prca.201000027DOI Listing
November 2010

Influence of CYP4F2 rs2108622 (V433M) on warfarin dose requirement in Asian patients.

Drug Metab Pharmacokinet 2011 12;26(2):130-6. Epub 2010 Nov 12.

Clinical Pharmacology Laboratory, Humphrey Oei Institute of Cancer Research, National Cancer Center, Singapore.

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http://dx.doi.org/10.2133/dmpk.dmpk-10-rg-080DOI Listing
September 2011

Pharmacogenetics of CYP1A2, novel polymorphisms and haplotypes in three distinct Asian populations.

Drug Metab Pharmacokinet 2010 1;25(6):616-23. Epub 2010 Oct 1.

Laboratory of Clinical Pharmacology, Division of Medical Sciences, Humphrey Oei Institute of Cancer Research, National Cancer Centre, Singapore.

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http://dx.doi.org/10.2133/dmpk.dmpk-10-sc-051DOI Listing
May 2011

Pharmacogenetics of target genes across doxorubicin disposition pathway: a review.

Curr Drug Metab 2010 Jan;11(1):115-28

Laboratory of Clinical Pharmacology, Division of Medical Sciences, Humphrey Oei Institute of Cancer Research National Cancer Centre, 11 Hospital Drive, Singapore 169610.

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http://dx.doi.org/10.2174/138920010791110890DOI Listing
January 2010

A comparative proteomic analysis of HepG2 cells incubated by S(-) and R(+) enantiomers of anti-coagulating drug warfarin.

Proteomics 2010 Apr;10(7):1463-73

School of Chemical and Biomedical Engineering, College of Engineering, Nanyang, Technological University, Singapore, Singapore.

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http://doi.wiley.com/10.1002/pmic.200900785
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http://dx.doi.org/10.1002/pmic.200900785DOI Listing
April 2010

VKORC1 diplotype-derived dosing model to explain variability in warfarin dose requirements in Asian patients.

Drug Metab Pharmacokinet 2009 ;24(4):365-75

Laboratory of Clinical Pharmacology, Division of Medical Sciences, Humphrey Oei Institute of Cancer Research, National Cancer Centre, Singapore.

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http://dx.doi.org/10.2133/dmpk.24.365DOI Listing
January 2010

Polymorphism of human cytochrome P450 enzymes and its clinical impact.

Drug Metab Rev 2009 ;41(2):89-295

School of Health Sciences, RMIT University, Bundoora, Victoria, Australia.

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http://www.tandfonline.com/doi/full/10.1080/0360253090284348
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http://dx.doi.org/10.1080/03602530902843483DOI Listing
September 2009

CBR1 and CBR3 pharmacogenetics and their influence on doxorubicin disposition in Asian breast cancer patients.

Cancer Sci 2008 Oct;99(10):2045-54

Laboratory of Clinical Pharmacology, Division of Medical Sciences, Humphrey Oei Institute of Cancer Research, National Cancer Centre, Singapore.

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http://dx.doi.org/10.1111/j.1349-7006.2008.00903.xDOI Listing
October 2008

PXR pharmacogenetics: association of haplotypes with hepatic CYP3A4 and ABCB1 messenger RNA expression and doxorubicin clearance in Asian breast cancer patients.

Clin Cancer Res 2008 Nov;14(21):7116-26

Laboratory of Clinical Pharmacology, Division of Medical Sciences, Humphrey Oei Institute of Cancer Research, Singapore, Singapore.

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http://dx.doi.org/10.1158/1078-0432.CCR-08-0411DOI Listing
November 2008

Phase I/II study of gemcitabine with pegylated liposomal doxorubicin as first-line therapy in Asian women with metastatic breast cancer.

Breast 2008 Oct 23;17(5):517-22. Epub 2008 May 23.

Department of Medical Oncology, National Cancer Centre, Singapore.

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http://dx.doi.org/10.1016/j.breast.2008.03.009DOI Listing
October 2008

Single nucleotide polymorphisms of the pregnane x receptor gene in Han Chinese and a comparison with other ethnic populations.

Pharmacology 2008 3;81(4):350-4. Epub 2008 Apr 3.

Institute of Clinical Pharmacology, School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou, China.

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http://dx.doi.org/10.1159/000123687DOI Listing
July 2008

Influence of ABCB1 and ABCG2 polymorphisms on doxorubicin disposition in Asian breast cancer patients.

Cancer Sci 2008 Apr;99(4):816-23

Laboratory of Clinical Pharmacology, Division of Medical Sciences, Humphrey Oei Institute of Cancer Research, National Cancer Center, 11 Hospital Drive, 169610 Singapore.

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http://dx.doi.org/10.1111/j.1349-7006.2008.00744.xDOI Listing
April 2008

A pharmacogenetic study of pregnane X receptor (NR1I2) in Han Chinese.

Curr Drug Metab 2007 Dec;8(8):778-86

Institute of Clinical Pharmacology, School of Pharmaceutical Sciences, Sun Yat-Sen University, Guangzhou, China.

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http://dx.doi.org/10.2174/138920007782798199DOI Listing
December 2007

Influence of APOE genotypes and VKORC1 haplotypes on warfarin dose requirements in Asian patients.

Br J Clin Pharmacol 2008 Feb 8;65(2):260-4. Epub 2007 Nov 8.

Laboratory of Clinical Pharmacology, Division of Medical Sciences, Humphrey Oei Institute of Cancer Research, National Cancer Centre, Singapore.

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http://dx.doi.org/10.1111/j.1365-2125.2007.03053.xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2291220PMC
February 2008

Role of UGT1A1*6, UGT1A1*28 and ABCG2 c.421C>A polymorphisms in irinotecan-induced neutropenia in Asian cancer patients.

Cancer Sci 2007 Sep 11;98(9):1461-7. Epub 2007 Jul 11.

Laboratory of Clinical Pharmacology, Division of Medical Sciences, Humphrey Oei Institute of Cancer Research, National Cancer Center, 11 Hospital Drive, Singapore 169610.

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http://doi.wiley.com/10.1111/j.1349-7006.2007.00541.x
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http://dx.doi.org/10.1111/j.1349-7006.2007.00541.xDOI Listing
September 2007

Novel SLC22A16 polymorphisms and influence on doxorubicin pharmacokinetics in Asian breast cancer patients.

Pharmacogenomics 2007 Jun;8(6):567-75

National Cancer Centre, Division of Medical Sciences, 11 Hospital Drive, 169610 Singapore.

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http://dx.doi.org/10.2217/14622416.8.6.567DOI Listing
June 2007

Role of P-glycoprotein in limiting the brain penetration of glabridin, an active isoflavan from the root of Glycyrrhiza glabra.

Pharm Res 2007 Sep 6;24(9):1668-90. Epub 2007 Jun 6.

Research Center of Medical Sciences, Guangdong Provincial People's Hospital, Guangdong Provincial Cardiovascular Institute, Guangzhou, 510080, China.

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http://dx.doi.org/10.1007/s11095-007-9297-1DOI Listing
September 2007

Transport of cryptotanshinone, a major active triterpenoid in Salvia miltiorrhiza Bunge widely used in the treatment of stroke and Alzheimer's disease, across the blood-brain barrier.

Curr Drug Metab 2007 May;8(4):365-78

Research Center of Medical Sciences, Guangdong Provincial People's Hospital, Guangdong Provincial Cardiovascular Institute, Guangzhou 510080, China.

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http://dx.doi.org/10.2174/138920007780655441DOI Listing
May 2007

Role of P-glycoprotein in the intestinal absorption of tanshinone IIA, a major active ingredient in the root of Salvia miltiorrhiza Bunge.

Curr Drug Metab 2007 May;8(4):325-40

Research Center of Medical Sciences, Guangdong Provincial People's Hospital, Guangdong Provincial Cardiovascular Institute, Guangzhou 510080, China.

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http://dx.doi.org/10.2174/138920007780655450DOI Listing
May 2007

High performance liquid chromatography with ultraviolet detection for the determination of SYUIQ-5, a novel telomerase inhibitor for cancer therapy: application to an enzyme kinetic study in rat liver microsomes.

J Chromatogr B Analyt Technol Biomed Life Sci 2007 Jul 8;854(1-2):332-7. Epub 2007 Apr 8.

Institute of Clinical Pharmacology, School of Pharmaceutical Sciences, Sun Yat-Sen University, 74 Zhongshan Road, Section 2, Guangzhou, China.

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http://dx.doi.org/10.1016/j.jchromb.2007.03.043DOI Listing
July 2007

Pharmacogenetics of SLCO1B1: haplotypes, htSNPs and hepatic expression in three distinct Asian populations.

Eur J Clin Pharmacol 2007 Jun 6;63(6):555-63. Epub 2007 Apr 6.

Laboratory of Clinical Pharmacology, Division of Medical Sciences, National Cancer Centre, 11 Hospital Drive, Singapore, 169610, Singapore.

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http://link.springer.com/10.1007/s00228-007-0285-5
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http://dx.doi.org/10.1007/s00228-007-0285-5DOI Listing
June 2007

Tanshinone IIB, a primary active constituent from Salvia miltiorrhza, exhibits neuro-protective activity in experimentally stroked rats.

Neurosci Lett 2007 May 12;417(3):261-5. Epub 2007 Mar 12.

Research Center of Medical Sciences, Guangdong Provincial People's Hospital, Guangdong Provincial Cardiovascular Institute, Guangzhou, and Department of Biological Science and Biotechnology, College of Bioengineering, Nanchang University, China.

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http://dx.doi.org/10.1016/j.neulet.2007.02.079DOI Listing
May 2007

Rapid and simultaneous determination of nifedipine and dehydronifedipine in human plasma by liquid chromatography-tandem mass spectrometry: Application to a clinical herb-drug interaction study.

J Chromatogr B Analyt Technol Biomed Life Sci 2007 Jun 21;852(1-2):534-44. Epub 2007 Feb 21.

Institute of Clinical Pharmacology, School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou, China.

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http://linkinghub.elsevier.com/retrieve/pii/S157002320700151
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http://dx.doi.org/10.1016/j.jchromb.2007.02.026DOI Listing
June 2007

Pharmacogenetics of target genes across the warfarin pharmacological pathway.

Clin Pharmacokinet 2006 ;45(12):1189-200

National Cancer Centre, Laboratory of Clinical Pharmacology, Division of Medical Sciences, Singapore, Singapore.

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http://dx.doi.org/10.2165/00003088-200645120-00004DOI Listing
February 2007

EGFR Intron 1 polymorphism in Asian Populations and its correlation with EGFR gene expression and amplification in breast tumor tissues.

Cancer Biol Ther 2006 Nov 1;5(11):1445-9. Epub 2006 Nov 1.

Laboratory of Clinical Pharmacology, National Cancer Centre, Singapore.

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http://dx.doi.org/10.4161/cbt.5.11.3457DOI Listing
November 2006

Pharmacogenetics of SLCO1B1 gene and the impact of *1b and *15 haplotypes on irinotecan disposition in Asian cancer patients.

Pharmacogenet Genomics 2006 Sep;16(9):683-91

Laboratory of Clinical Pharmacology, Division of Medical Sciences, National Cancer Centre, National University Hospital, Singapore.

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http://dx.doi.org/10.1097/01.fpc.0000230420.05221.71DOI Listing
September 2006

Evidence for selective expression of the p53 codon 72 polymorphs: implications in cancer development.

Cancer Epidemiol Biomarkers Prev 2005 Sep;14(9):2245-52

Laboratory of Molecular Carcinogenesis, National Cancer Centre, Singapore.

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http://dx.doi.org/10.1158/1055-9965.EPI-05-0153DOI Listing
September 2005

Meta-analysis of the influence of MDR1 C3435T polymorphism on digoxin pharmacokinetics and MDR1 gene expression.

Br J Clin Pharmacol 2005 Aug;60(2):159-71

Laboratory of Clinical Pharmacology, Division of Clinical Trials and Epidemiological Sciences, National Cancer Centre, Singapore.

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http://dx.doi.org/10.1111/j.1365-2125.2005.02392.xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1884933PMC
August 2005

Enhancing the therapeutic responsiveness of photodynamic therapy with the antiangiogenic agents SU5416 and SU6668 in murine nasopharyngeal carcinoma models.

Cancer Chemother Pharmacol 2005 Dec 7;56(6):569-77. Epub 2005 Jul 7.

Laboratory of Clinical Pharmacology Division of Clinical Trials & Epidemiological Sciences, National Cancer Centre, 11, Hospital Drive, 169610, Singapore.

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http://dx.doi.org/10.1007/s00280-005-1017-0DOI Listing
December 2005

An interethnic comparison of polymorphisms of the genes encoding drug-metabolizing enzymes and drug transporters: experience in Singapore.

Drug Metab Rev 2005 ;37(2):327-78

Laboratory of Clinical Pharmacology, Division of Clinical Trials and Epidemiological Sciences, National Cancer Centre, Singapore.

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http://dx.doi.org/10.1081/dmr-28805DOI Listing
August 2005

Pharmacogenetic profiling across the irinotecan pathway in Asian patients with cancer.

Br J Clin Pharmacol 2005 Apr;59(4):415-24

Laboratory of Clinical Pharmacology, Division of Clinical Trials and Epidemiological Sciences, National Cancer Centre, Singapore 169610.

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http://doi.wiley.com/10.1111/j.1365-2125.2004.02330.x
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http://dx.doi.org/10.1111/j.1365-2125.2004.02330.xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1884809PMC
April 2005

Phase II study of irinotecan (CPT-11) as salvage therapy for advanced nasopharyngeal carcinoma.

Cancer 2005 Feb;103(3):576-81

Department of Medical Oncology, National Cancer Center, Singapore.

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http://doi.wiley.com/10.1002/cncr.20802
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http://dx.doi.org/10.1002/cncr.20802DOI Listing
February 2005

Herbal modulation of P-glycoprotein.

Drug Metab Rev 2004 Feb;36(1):57-104

Department of Pharmacy, Faculty of Science, National University of Singapore, Singapore.

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https://www.tandfonline.com/doi/full/10.1081/DMR-120028427
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http://dx.doi.org/10.1081/dmr-120028427DOI Listing
February 2004

Influence of multiple dose activated charcoal on the disposition kinetics of irinotecan in rats.

Drug Metabol Drug Interact 2002 ;19(2):137-48

Laboratory of Clinical Pharmacology, Division of Clinical Trials and Epidemiological Sciences, National Cancer Centre, Singapore.

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http://dx.doi.org/10.1515/dmdi.2002.19.2.137DOI Listing
June 2003

The modulation of irinotecan-induced diarrhoea and pharmacokinetics by three different classes of pharmacologic agents.

Oncol Rep 2003 May-Jun;10(3):745-51

Clinical Pharmacology Unit, Division of Clinical Trials and Epidemiological Sciences, National Cancer Centre, Singapore 11, Hospital Drive, Singapore 169610, Singapore.

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December 2003

Genetic polymorphisms in MDR1 and CYP3A4 genes in Asians and the influence of MDR1 haplotypes on cyclosporin disposition in heart transplant recipients.

Pharmacogenetics 2003 Feb;13(2):89-95

Laboratory of Clinical Pharmacology, Division of Clinical Trials and Epidemiological Sciences, National Cancer Centre, 11 Hospital Drive, Singapore 169610, Republic of Singapore.

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http://dx.doi.org/10.1097/00008571-200302000-00005DOI Listing
February 2003

Determination of doxorubicin and its metabolites in rat serum and bile by LC: application to preclinical pharmacokinetic studies.

J Pharm Biomed Anal 2002 Nov;30(4):1063-74

Clinical Pharmacology Unit, Division of Clinical Trials and Epidemiological Sciences, National Cancer Centre, 11 Hospital Drive, 169610, Singapore, Singapore.

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http://dx.doi.org/10.1016/s0731-7085(02)00442-9DOI Listing
November 2002

Effect of coenzyme Q10 on the disposition of doxorubicin in rats.

Eur J Drug Metab Pharmacokinet 2002 Jul-Sep;27(3):185-92

Clinical Pharmacology Unit, Division of Clinical Trials & Epidemiological Sciences, National Cancer Centre, 11 Hospital Drive, Singapore 169610, Republic of Singapore.

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http://dx.doi.org/10.1007/BF03190456DOI Listing
March 2003

Genetic polymorphisms of UDP-glucuronosyltransferase in Asians: UGT1A1*28 is a common allele in Indians.

Pharmacogenetics 2002 Jan;12(1):81-3

Laboratory of Clinical Pharmacology, Division of Clinical Trials and Epidemiological Sciences, National Cancer Centre, Singapore.

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http://dx.doi.org/10.1097/00008571-200201000-00012DOI Listing
January 2002