Publications by authors named "Balazs Hegedus"

100Publications

[Therapeutic possibilities in KRAS-mutant lung adenocarcinoma].

Magy Onkol 2020 Sep 6;64(3):231-244. Epub 2020 Aug 6.

Mellkassebészeti Osztály, Országos Onkológiai Intézet, Budapest, Hungary.

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September 2020

Dataset of a study investigating autologous blood patch pleurodesis in postoperative prolonged air leaks after lung resection.

Data Brief 2020 Aug 4;31:105789. Epub 2020 Jun 4.

Department of Thoracic Surgery and Thoracic Endoscopy, Ruhrlandklinik, West German Lung Center, University Hospital Essen, University Duisburg-Essen, Essen, Germany.

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http://dx.doi.org/10.1016/j.dib.2020.105789DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7317670PMC
August 2020

A Prospective Study Investigating Blood Patch Pleurodesis for Postoperative Air Leaks After Pulmonary Resection.

J Surg Res 2020 11 20;255:240-246. Epub 2020 Jun 20.

Department of Thoracic Surgery and Thoracic Endoscopy, Ruhrlandklinik, West German Lung Center, University Hospital Essen, University Duisburg-Essen, Essen, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.jss.2020.05.012DOI Listing
November 2020

Current therapy of KRAS-mutant lung cancer.

Cancer Metastasis Rev 2020 Dec;39(4):1159-1177

Department of Thoracic Surgery, National Institute of Oncology-Semmelweis University, Rath Gyorgy u. 7-9, Budapest, 1122, Hungary.

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http://dx.doi.org/10.1007/s10555-020-09903-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7680319PMC
December 2020

K-Ras prenylation as a potential anticancer target.

Cancer Metastasis Rev 2020 Dec;39(4):1127-1141

Department of Thoracic Surgery, Ruhrlandklinik, University Duisburg-Essen, Essen, Germany.

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http://dx.doi.org/10.1007/s10555-020-09902-wDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7680335PMC
December 2020

HDAC inhibition synergizes with ALK inhibitors to overcome resistance in a novel ALK mutated lung adenocarcinoma model.

Lung Cancer 2020 06 18;144:20-29. Epub 2020 Apr 18.

Department of Thoracic Surgery, West German Cancer Center, University Hospital Essen - Ruhrlandklinik, University Duisburg-Essen, Essen, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.lungcan.2020.04.002DOI Listing
June 2020

[Impact of prenylation inhibition on RAS mutant tumors in preclinical studies].

Magy Onkol 2019 Dec 30;63(4):320-329. Epub 2019 Oct 30.

II. Sz. Patológiai Intézet, Semmelweis Egyetem, Budapest, Hungary.

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December 2019

Detection of TGF-β in pleural effusions for diagnosis and prognostic stratification of malignant pleural mesothelioma.

Lung Cancer 2020 01 18;139:124-132. Epub 2019 Nov 18.

Department of Thoracic Surgery, Ruhrlandklinik, West German Cancer Center, University Hospital Essen, University Duisburg-Essen, Tueschener Weg 40, 45239, Essen, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.lungcan.2019.11.013DOI Listing
January 2020

Implementation of an experimental isolated lung perfusion model on surgically resected human lobes.

Sci Rep 2019 08 21;9(1):12193. Epub 2019 Aug 21.

Department of Thoracic Surgery and Thoracic Endoscopy, University Medicine Essen-Ruhrlandklinik, Essen, Germany.

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http://dx.doi.org/10.1038/s41598-019-48719-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6704181PMC
August 2019

Primary Human Fibroblasts in Culture Switch to a Myofibroblast-Like Phenotype Independently of TGF Beta.

Cells 2019 07 13;8(7). Epub 2019 Jul 13.

Cardiac Surgery Research Laboratory, Department of Surgery, Medical University of Vienna, 1090 Vienna, Austria.

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http://dx.doi.org/10.3390/cells8070721DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6678602PMC
July 2019

Prognostic factors for pulmonary metastasectomy in malignant melanoma: size matters.

Eur J Cardiothorac Surg 2019 Dec;56(6):1104-1109

Department of Thoracic Surgery, University Medicine Essen-Ruhrlandklinik, University of Duisburg-Essen, Essen, Germany.

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http://dx.doi.org/10.1093/ejcts/ezz211DOI Listing
December 2019

DNA damage predicts prognosis and treatment response in colorectal liver metastases superior to immunogenic cell death and T cells.

Theranostics 2018 10;8(12):3198-3213. Epub 2018 May 10.

Division of General Surgery, Department of Surgery, Comprehensive Cancer Center Vienna, Medical University of Vienna, Waehringer Guertel 18-20, A-1090 Vienna, Austria.

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http://dx.doi.org/10.7150/thno.24699DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6010984PMC
August 2019

The role of Allee effect in modelling post resection recurrence of glioblastoma.

PLoS Comput Biol 2017 Nov 17;13(11):e1005818. Epub 2017 Nov 17.

Department of Biological Physics, Eotvos University, Budapest, Hungary.

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http://dx.doi.org/10.1371/journal.pcbi.1005818DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5711030PMC
November 2017

Targeting an Oncolytic Influenza A Virus to Tumor Tissue by Elastase.

Mol Ther Oncolytics 2017 Dec 8;7:37-44. Epub 2017 Sep 8.

Research Institute of Influenza, Russian Academy of Medical Sciences, Prof. Popova Str. 15/17, 196376 St. Petersburg, Russia.

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http://dx.doi.org/10.1016/j.omto.2017.09.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5633860PMC
December 2017

Same-day Routine Chest-X Ray After Thoracic Surgery is Not Necessary!

Zentralbl Chir 2018 Feb 13;143(1):96-101. Epub 2017 Sep 13.

Thoraxchirurgie, Lungenklinik Hemer, Germany.

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http://dx.doi.org/10.1055/s-0043-117174DOI Listing
February 2018

BARD1 serum autoantibodies for the detection of lung cancer.

PLoS One 2017 7;12(8):e0182356. Epub 2017 Aug 7.

Molecular Gynecology and Obstetrics Laboratory, Department of Gynecology and Obstetrics, Medical Genetics and Laboratories, Geneva University Hospitals, Geneva, Switzerland.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0182356PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5546601PMC
October 2017

Limited Tumor Tissue Drug Penetration Contributes to Primary Resistance against Angiogenesis Inhibitors.

Theranostics 2017 1;7(2):400-412. Epub 2017 Jan 1.

National Korányi Institute of Pulmonology, Budapest, Hungary;; Division of Thoracic Surgery, Department of Surgery, Comprehensive Cancer Center, Medical University of Vienna, Austria;; Department of Thoracic Surgery, Semmelweis University and National Institute of Oncology, Budapest, Hungary;; Department of Biomedical Imaging and Image-guided Therapy, Division of Molecular and Gender Imaging, Medical University of Vienna, Vienna, Austria.

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http://dx.doi.org/10.7150/thno.16767DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5197073PMC
October 2017

A comparison of sample preparation strategies for biological tissues and subsequent trace element analysis using LA-ICP-MS.

Anal Bioanal Chem 2017 Mar 14;409(7):1805-1814. Epub 2016 Dec 14.

Institute of Chemical Technologies and Analytics, TU Wien, Getreidemarkt 9/164-IAC, 1060, Vienna, Austria.

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http://dx.doi.org/10.1007/s00216-016-0124-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5591616PMC
March 2017

Oncolytic influenza A virus expressing interleukin-15 decreases tumor growth in vivo.

Surgery 2017 03 21;161(3):735-746. Epub 2016 Oct 21.

Department of Surgery, Medical University of Vienna, Vienna, Austria; Comprehensive Cancer Center Vienna, Medical University of Vienna, Vienna, Austria. Electronic address:

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http://dx.doi.org/10.1016/j.surg.2016.08.045DOI Listing
March 2017

Trabectedin Is Active against Malignant Pleural Mesothelioma Cell and Xenograft Models and Synergizes with Chemotherapy and Bcl-2 Inhibition In Vitro.

Mol Cancer Ther 2016 10 10;15(10):2357-2369. Epub 2016 Aug 10.

Applied and Experimental Oncology, Institute of Cancer Research, Department of Medicine I, Comprehensive Cancer Center, Medical University of Vienna, Vienna, Austria.

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http://dx.doi.org/10.1158/1535-7163.MCT-15-0846DOI Listing
October 2016

Circulating activin A is a novel prognostic biomarker in malignant pleural mesothelioma - A multi-institutional study.

Eur J Cancer 2016 08 8;63:64-73. Epub 2016 Jun 8.

Division of Thoracic Surgery, Department of Surgery, Comprehensive Cancer Center Vienna, Medical University of Vienna, Vienna, Austria; Department of Biomedical Imaging and Image-guided Therapy, Division of Molecular and Gender Imaging, Medical University of Vienna, Vienna, Austria; MTA-SE Molecular Oncology Research Group, Hungarian Academy of Sciences, Budapest, Hungary. Electronic address:

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http://dx.doi.org/10.1016/j.ejca.2016.04.018DOI Listing
August 2016

High circulating activin A level is associated with tumor progression and predicts poor prognosis in lung adenocarcinoma.

Oncotarget 2016 Mar;7(12):13388-99

Translational Thoracic Oncology Laboratory, Division of Thoracic Surgery, Department of Surgery, Comprehensive Cancer Center Vienna, Medical University of Vienna, Vienna, Austria.

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http://dx.doi.org/10.18632/oncotarget.7796DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4924649PMC
March 2016

RIG-I inhibits the MAPK-dependent proliferation of BRAF mutant melanoma cells via MKP-1.

Cell Signal 2016 May 29;28(5):335-347. Epub 2016 Jan 29.

Department of Immunology, Faculty of Medicine, University of Debrecen, Debrecen, Hungary; Sapientia Hungarian University of Transylvania, Department of Bioengineering, Miercurea-Ciuc, Romania.

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http://dx.doi.org/10.1016/j.cellsig.2016.01.012DOI Listing
May 2016

Application of dried-droplets deposited on pre-cut filter paper disks for quantitative LA-ICP-MS imaging of biologically relevant minor and trace elements in tissue samples.

Anal Chim Acta 2016 Feb 11;908:54-62. Epub 2016 Jan 11.

TU Wien, Institute of Chemical Technologies and Analytics, Vienna, Austria. Electronic address:

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http://dx.doi.org/10.1016/j.aca.2015.12.048DOI Listing
February 2016

Differences in the Epidemiology of Rare EGFR Mutations in Different Populations.

J Thorac Oncol 2016 Jan;11(1):e19-20

Translational Thoracic Oncology Laboratory, Division of Thoracic Surgery, Department of Surgery, Comprehensive Cancer Center, Medical University of Vienna, Austria; 2nd Department of Pathology, Semmelweis University, Budapest, Hungary; Molecular Oncology Research Group, Hungarian Academy of Sciences-Semmelweis University, Budapest, Hungary.

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http://dx.doi.org/10.1016/j.jtho.2015.09.003DOI Listing
January 2016

[Melanoma research in Hungary: promising results in a previously orphan tumor].

Magy Onkol 2015 Dec 25;59(4):275-81. Epub 2015 Oct 25.

II. Sz. Patológiai Intézet, Semmelweis Egyetem, Budapest, Hungary.

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December 2015

Reply to Rare Versus Artifactual EGFR Mutations.

J Thorac Oncol 2015 Aug;10(8):e80-1

National Koranyi Institute of Pulmonology, Budapest, Hungary, Translational Thoracic Oncology Laboratory, Division of Thoracic Surgery, Department of Surgery, Comprehensive Cancer Center, Medical University of Vienna, Vienna, Austria, Department of Thoracic Surgery, National Institute of Oncology-Semmelweis University, Budapest, Hungary National Koranyi Institute of Pulmonology, Budapest, Hungary National Koranyi Institute of Pulmonology, Budapest, Hungary, Department of Thoracic Surgery, National Institute of Oncology-Semmelweis University, Budapest, Hungary National Koranyi Institute of Pulmonology, Budapest, Hungary, Translational Thoracic Oncology Laboratory, Division of Thoracic Surgery, Department of Surgery, Comprehensive Cancer Center, Medical University of Vienna, Vienna, Austria, Department of Thoracic Surgery, National Institute of Oncology-Semmelweis University, Budapest, Hungary Translational Thoracic Oncology Laboratory, Division of Thoracic Surgery, Department of Surgery, Comprehensive Cancer Center, Medical University of Vienna, Vienna, Austria, 2nd Department of Pathology, Semmelweis University, Budapest, Hungary, Molecular Oncology Research Group, Hungarian Academy of Sciences-Semmelweis University, Budapest, Hungary.

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http://dx.doi.org/10.1097/JTO.0000000000000591DOI Listing
August 2015

Stromal expression of heat-shock protein 27 is associated with worse clinical outcome in patients with colorectal cancer lung metastases.

PLoS One 2015 20;10(3):e0120724. Epub 2015 Mar 20.

Department of Thoracic Surgery, Medical University of Vienna, Vienna, Austria; Christian Doppler Laboratory for Cardiac and Thoracic Diagnosis and Regeneration, Medical University of Vienna, Vienna, Austria.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0120724PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4368667PMC
February 2016

Distinct Epidemiology and Clinical Consequence of Classic Versus Rare EGFR Mutations in Lung Adenocarcinoma.

J Thorac Oncol 2015 May;10(5):738-746

Translational Thoracic Oncology Laboratory, Division of Thoracic Surgery, Department of Surgery, Comprehensive Cancer Center, Medical University of Vienna, Austria; Molecular Oncology Research Group, Hungarian Academy of Sciences-Semmelweis University, Budapest, Hungary. Electronic address:

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http://dx.doi.org/10.1097/JTO.0000000000000492DOI Listing
May 2015

Effectiveness of erlotinib treatment in advanced KRAS mutation-negative lung adenocarcinoma patients: Results of a multicenter observational cohort study (MOTIVATE).

Lung Cancer 2014 Oct 27;86(1):54-8. Epub 2014 Jul 27.

Department of Pulmonology, Semmelweis University, Diósárok utca 1/C, 1125 Budapest, Hungary. Electronic address:

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http://dx.doi.org/10.1016/j.lungcan.2014.07.011DOI Listing
October 2014

Antimicrobial peptides are highly abundant and active in postoperative pleural drainage fluids.

Ann Thorac Surg 2014 Sep 16;98(3):1042-50. Epub 2014 Jul 16.

Department of Dermatology, Research Division of Biology and Pathobiology of the Skin, Medical University Vienna, Austria.

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http://dx.doi.org/10.1016/j.athoracsur.2014.04.106DOI Listing
September 2014

Apelin promotes lymphangiogenesis and lymph node metastasis.

Oncotarget 2014 Jun;5(12):4426-37

Division of Thoracic Surgery, Department of Surgery, Comprehensive Cancer Center, Medical University of Vienna, Austria; Department of Tumor Biology, National Koranyi Institute of Pulmonology, Budapest, Hungary; Thoracic Surgery, National Institute of Oncology and Semmelweis University, Budapest, Hungary.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4147335PMC
http://dx.doi.org/10.18632/oncotarget.2032DOI Listing
June 2014

Subtype-specific KRAS mutations in advanced lung adenocarcinoma: a retrospective study of patients treated with platinum-based chemotherapy.

Eur J Cancer 2014 Jul 22;50(10):1819-1828. Epub 2014 Apr 22.

Department of Tumor Biology, National Koranyi Institute of Pulmonology, Budapest, Hungary; Division of Thoracic Surgery, Medical University of Vienna, Austria; Department of Thoracic Surgery, National Institute of Oncology-Semmelweis University, Budapest, Hungary. Electronic address:

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http://dx.doi.org/10.1016/j.ejca.2014.04.001DOI Listing
July 2014

Expression of microRNA-21 in non-small cell lung cancer tissue increases with disease progression and is likely caused by growth conditional changes during malignant transformation.

Int J Oncol 2014 Apr 22;44(4):1325-34. Epub 2014 Jan 22.

Institute of Cancer Research, Department of Medicine I, Comprehensive Cancer Center, Medical University of Vienna, A-1090 Vienna, Austria.

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http://dx.doi.org/10.3892/ijo.2014.2272DOI Listing
April 2014

Angiogenesis and angiogenic tyrosine kinase receptor expression in pediatric brain tumors.

Pathol Oncol Res 2014 Apr 5;20(2):417-26. Epub 2013 Nov 5.

2nd Department of Pediatrics, Semmelweis University, Budapest, Hungary.

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http://dx.doi.org/10.1007/s12253-013-9711-4DOI Listing
April 2014

Encephalitis and GABAB receptor antibodies: novel findings in a new case series of 20 patients.

Neurology 2013 Oct 25;81(17):1500-6. Epub 2013 Sep 25.

From the Service of Neurology (R.H., M.T., L.S., A.S., F.G.), Hospital Clínic, Universitat de Barcelona and Institut d'Investigació Biomèdica August Pi i Sunyer (IDIBAPS), Barcelona, Spain; Institute of Neurology (R.H.), Medical University of Vienna, Austria; Department of Neurology (M.T.), Erasmus Medical Center, Rotterdam, the Netherlands; Department of Tumor Biology (B.D., A.R., B.H., M.A.H., V.L.), National Koranyi Institute of TB and Pulmonology, Budapest, Hungary; Department of Thoracic Surgery (B.D., A.R., B.H., M.A.H., V.L., H.J.A.), Medical University of Vienna, Austria; 2nd Department of Pathology (B.H.), Semmelweis University, Budapest, Hungary; Christian Doppler Laboratory for Cardiac and Thoracic Diagnosis and Regeneration (H.J.A.), Vienna, Austria; Department of Neurology (L.H.), Charité University Medicine Berlin, Germany; Servicio Neurología (S.B.), Hospital de Cruces, Barakaldo; Servicio Neurología (A.d.F.), Hospital Ramón y Cajal, Madrid; Institució Catalana de Recerca i Estudis Avançats (ICREA) (J.D.), IDIBAPS, Hospital Clínic, Barcelona, Spain; and Department of Neurology (J.D.), University of Pennsylvania, Philadelphia.

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http://dx.doi.org/10.1212/WNL.0b013e3182a9585fDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3888170PMC
October 2013

Mononuclear cell secretome protects from experimental autoimmune myocarditis.

Eur Heart J 2015 Mar 14;36(11):676-85. Epub 2013 Jan 14.

Department of Thoracic Surgery, Medical University Vienna, Vienna, Austria Christian Doppler Laboratory for Cardiac and Thoracic Diagnosis and Regeneration, Währinger Gürtel 18-20, 1090 Vienna, Austria

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http://dx.doi.org/10.1093/eurheartj/ehs459DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4359357PMC
March 2015

Lung cancer in never smokers.

Future Oncol 2011 Oct;7(10):1195-211

National Koranyi Institute of Pulmonology, Budapest, Hungary.

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https://www.futuremedicine.com/doi/10.2217/fon.11.100
Publisher Site
http://dx.doi.org/10.2217/fon.11.100DOI Listing
October 2011

[Effect of KRAS mutation status on the efficiency of Avastin therapy of colorectal cancer].

Magy Onkol 2011 Jun 8;55(2):99-100, 102-4. Epub 2011 Apr 8.

II. számú Patológiai Intézet, Semmelweis Egyetem, Budapest, Hungary.

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http://dx.doi.org/MagyOnkol.2011.55.2.99DOI Listing
June 2011

KRAS mutation testing of colorectal cancer for anti-EGFR therapy: dogmas versus evidence.

Curr Cancer Drug Targets 2010 Dec;10(8):813-23

2nd Department of Pathology, Semmelweis University, Budapest, H-1091, Hungary.

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http://dx.doi.org/10.2174/156800910793357989DOI Listing
December 2010

Optic nerve dysfunction in a mouse model of neurofibromatosis-1 optic glioma.

J Neuropathol Exp Neurol 2009 May;68(5):542-51

Department of Neurology, Washington University School of Medicine, St Louis, MO 63110, USA.

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http://dx.doi.org/10.1097/NEN.0b013e3181a3240bDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2746323PMC
May 2009

Neurofibromin regulates somatic growth through the hypothalamic-pituitary axis.

Hum Mol Genet 2008 Oct 9;17(19):2956-66. Epub 2008 Jul 9.

Department of Neurology, Washington University School of Medicine, St Louis, MO 63110, USA.

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http://dx.doi.org/10.1093/hmg/ddn194DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2596853PMC
October 2008

Generation of a reporter mouse line expressing Akt and EGFP upon Cre-mediated recombination.

Genesis 2008 May;46(5):256-64

Division of Endocrinology, Department of Internal Medicine, Metabolism and Lipid Research, Washington University School of Medicine, Saint Louis, Missouri 63110-1010, USA.

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http://dx.doi.org/10.1002/dvg.20388DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2584870PMC
May 2008

Preclinical cancer therapy in a mouse model of neurofibromatosis-1 optic glioma.

Cancer Res 2008 Mar;68(5):1520-8

Department of Neurology, Washington University School of Medicine, St. Louis, MO 63110, USA.

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http://dx.doi.org/10.1158/0008-5472.CAN-07-5916DOI Listing
March 2008