Publications by authors named "Bailong Hu"

26 Publications

  • Page 1 of 1

Pre-operative ultrasonographic evaluation of subclavian/infraclavicular axillary vein.

Eur J Anaesthesiol 2021 07;38(7):790-791

From the Department of Central Laboratory, The Second Affiliated Hospital of Guizhou University of Traditional Chinese Medicine, (HZ) and Department of Anaesthesiology, The Affiliated Hospital of Guizhou Medical University, Guiyang, China (BH).

View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1097/EJA.0000000000001355DOI Listing
July 2021

Two-handed jaw thrust in patients undergoing intubation with a double-lumen endobronchial tube.

Eur J Anaesthesiol 2021 02;38(2):184-185

From the Department of Anaesthesiology (BH, XZ) and Department of Clinical Research Centre, The Affiliated Hospital of Guizhou Medical University, Guiyang, China (HZ).

View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1097/EJA.0000000000001283DOI Listing
February 2021

Preoperative ultrasonographic evaluation of inferior vena cava collapsibility index and caval aorta index.

Eur J Anaesthesiol 2020 09;37(9):835

From the Department of Anaesthesiology (BH, XZ) and Department of Clinical Research Centre, The Affiliated Hospital of Guizhou Medical University, Guiyang, China (HZ).

View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1097/EJA.0000000000001228DOI Listing
September 2020

Reintubation in the ICU versus in the operating room in cardiac surgery patients.

Eur J Anaesthesiol 2020 09;37(9):818

From the Department of Anaesthesiology (BH, XZ), and Department of Clinical Research Centre, The Affiliated Hospital of Guizhou Medical University, Guiyang, China (HZ).

View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1097/EJA.0000000000001225DOI Listing
September 2020

Comparative Transcriptome Analysis Reveals the Potential Cardiovascular Protective Targets of the Thyroid Hormone Metabolite 3-Iodothyronamine (3-T1AM).

Biomed Res Int 2020 19;2020:1302453. Epub 2020 Jun 19.

Department of Cardiology, The Second Affiliated Hospital of Guizhou University of Traditional Chinese Medicine, 550004 Guiyang, China.

Background: The thyroid hormone metabolite 3-iodothyronamine (3-T1AM) is rapidly emerging as a promising compound in decreasing the heart rate and lowering the cardiac output. The aim of our study was to fully understand the molecular mechanism of 3-T1AM on cardiomyocytes and its potential targets in cardiovascular diseases.

Materials And Methods: In our study, we utilized RNA-Seq to characterize the gene expression in H9C2 cells after 3-T1AM treatment. Comparative transcriptome analysis, including gene ontology, signaling pathways, disease connectivity analysis, and protein-protein interaction networks (PPI), was presented to find the critical gene function, hub genes, and related pathways.

Results: A total of 1494 differently expressed genes (DEGs) were identified (192 upregulated and 1302 downregulated genes) in H9C2 cells for 3-T1AM treatment. Of these, 90 genes were associated with cardiovascular diseases. The PPI analysis indicated that 5 hub genes might be the targets of 3-T1AM. Subsequently, eight DEGs characterized using RNA-Seq were confirmed by RT-qPCR assays.

Conclusions: Our study provides a comprehensive analysis of 3-T1AM on H9C2 cells and delineates a new insight into the therapeutic intervention of 3-T1AM for the cardiovascular diseases.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1155/2020/1302453DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7322601PMC
April 2021

A Comparison of Dexmedetomidine and Midazolam for the Prevention of Postoperative Nausea and Vomiting Caused by Hemabate in Cesarean Delivery: A Randomized Controlled Trial.

Drug Des Devel Ther 2020 28;14:2127-2133. Epub 2020 May 28.

Department of Anesthesiology, The Affiliated Hospital of Guizhou Medical University, Guiyang,People's Republic of China.

Objective: To compare the efficacy of dexmedetomidine and midazolam in the prevention of postoperative nausea and vomiting (PONV) caused by hemabate in postpartum hemorrhage during cesarean delivery.

Methods: One hundred and five parturients with American Society of Anesthesiology (ASA) physical status I and II, aged 20-40 years, undergoing elective cesarean delivery under epidural anesthesia were randomly allocated into dexmedetomidine group (group D, n=35), midazolam group (group M, n=35) and control group (group C, n=35). Patients received an intrauterine injection of 250 μg hemabate and continuous intravenous infusion of 5 units oxytocin immediately following the delivery of the infant. At the same time, patients in group D received 1μg/kg intravenous dexmedetomidine, group M received 0.02 mg/kg intravenous midazolam and group C received 20 mL intravenous saline. Parameters such as the PONV, other adverse reactions (chest distress, flush, etc.) caused by hemabate, patient satisfaction, the sedation (OAA/S) scores, and the hemodynamic parameters were recorded in both groups.

Results: The PONV incidence in group D and group M was significantly lower compared with group C (6%, 17%, and 71% for group D, group M, and group C, respectively, P<0.05). The sedation (OAA/S) scores in group D and group M was significantly higher compared with group C (1.62±0.28, 1.75±0.31, and 1.00±0.00 for group D, group M, and group C, respectively, P<0.05). The patient satisfaction in group D and group M was significantly higher compared with group C (94%, 69%, and 46% for group D, group M, and group C, respectively, P<0.05). Furthermore, there were more patients satisfied with group D than group M (94% vs.69%, P<0.05).

Conclusion: Intravenous dexmedetomidine (1 μg/kg) and midazolam (0.02 mg/kg) were equally effective in preventing PONV introduced by hemabate and dexmedetomidine is superior to midazolam in patient satisfaction.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.2147/DDDT.S251525DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7266306PMC
March 2021

Thyroid Hormone Metabolite 3-Iodothyronamine (T1AM) Alleviates Hypoxia/Reoxygenation-Induced Cardiac Myocyte Apoptosis via Akt/FoxO1 Pathway.

Med Sci Monit 2020 Mar 12;26:e923195. Epub 2020 Mar 12.

Deparment of Basic Medicine, Guizhou Medical University, Guiyang, Guizhou, China (mainland).

BACKGROUND The thyroid hormone metabolite 3-iodothyronamine (T1AM) is rapidly emerging as promising compound of decreasing heart rate and lowering cardiac output. The aim of our study was to fully understand the molecular mechanism of T1AM on cardiomyocytes and its potential targets in cardiovascular diseases. MATERIAL AND METHODS We developed an in vitro myocardial ischemia-reperfusion injury model of AC-16 cells by hypoxia-reoxygenation injury. Cell viability of AC-16 cells was detected using CCK-8 assay and apoptosis was detected by flow cytometry. RNA-seq was used to characterize the gene expression in H/R-induced AC-16 cells after T1AM treatment. The mRNA levels of FoxO1, PPARalpha, Akt, and GCK and the protein levels of PPARalpha, GCK, and components of the Akt/FoxO1 pathway were detected by qRT-PCR and Western blotting, respectively. RESULTS Exogenous T1AM increased the H/R-induced AC-16 cell viability in a relatively low concentration. A total of 210 DEGs, including 142 upregulated and 68 downregulated genes, were determined in H/R-induced AC-16 cells treated with or without T1AM. A Venn diagram showed 135 common DEGs. The FoxO signaling pathway was identified via KEGG enrichment analysis of these 135 DEGs. Moreover, T1AM mediated hypometabolism and reduced the apoptosis of H/R-induced AC-16 cells via the Akt/FoxO1 pathway. CONCLUSIONS Exogenous T1AM protects against cell injury induced by H/R in AC-16 cells via regulation of the FoxO signaling pathway. Our results suggest that T1AM can play a preventive role in myocardial H/R injury and also provide new insight for clinical management of AMI patients.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.12659/MSM.923195DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7081925PMC
March 2020

Focused Cardiac Ultrasonography for Left Ventricular Systolic Function.

N Engl J Med 2020 03;382(10):977

Affiliated Hospital of Guizhou Medical University, Guiyang, China

View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1056/NEJMc2000059DOI Listing
March 2020

Is resting pupil size a predictor of GAIH?

J Anesth 2020 04 31;34(2):314. Epub 2020 Jan 31.

Department of Anesthesiology, The Affiliated Hospital of Guizhou Medical University, No. 28 Guiyi Street, Yunyan District, Guiyang, 550004, China.

View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1007/s00540-020-02744-4DOI Listing
April 2020

Measurement of gastric emptying time by ultrasonography.

J Anesth 2020 04 20;34(2):313. Epub 2020 Jan 20.

Department of Anesthesiology, The Affiliated Hospital of Guizhou Medical University, No. 28 Guiyi Street, Yunyan District 550004, Guiyang, China.

View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1007/s00540-020-02735-5DOI Listing
April 2020

Comparing the analgesic efficacy of infiltration analgesia vs. intrathecal morphine after total knee arthroplasty.

Eur J Anaesthesiol 2020 01;37(1):55

From the Department of Anesthesiology (BH, XZ, KJ), and Department of Clinical Research Centre, The Affiliated Hospital of Guizhou Medical University, Guiyang, China (HZ).

View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1097/EJA.0000000000001049DOI Listing
January 2020

Letter to the editor concerning "Demographics, presentation and symptoms of patients with Klippel-Feil syndrome: analysis of a global patient-reported registry" by Nouri et al. [Eur Spine J; (2019) 28(10): 2257-2265].

Eur Spine J 2020 02 26;29(2):384. Epub 2019 Nov 26.

Department of Anesthesiology, The Affiliated Hospital of Guizhou Medical University, No. 28 Guiyi Street, Yunyan District, 550004, Guiyang, China.

View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1007/s00586-019-06228-2DOI Listing
February 2020

TO THE EDITOR.

Spine (Phila Pa 1976) 2019 12;44(23):E1409

Department of Anesthesiology, The Affiliated Hospital of Guizhou Medical University, Guiyang, China.

View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1097/BRS.0000000000003261DOI Listing
December 2019

Propofol vs. thiopental in hypotention after GA induction.

J Anesth 2019 Dec 24;33(6):705. Epub 2019 Sep 24.

Department of Anesthesiology, The Affiliated Hospital of Guizhou Medical University, No. 28 Guiyi Street, Yunyan District, Guiyang, 550004, China.

View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1007/s00540-019-02686-6DOI Listing
December 2019

Three versus five lumbar PVB injections for herniorrhaphy.

J Anesth 2019 06 5;33(3):491. Epub 2019 Apr 5.

Department of Anesthesiology, The Affiliated Hospital of Guizhou Medical University, No. 28 Guiyi Street, Yunyan District, Guiyang, 550004, China.

View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1007/s00540-019-02636-2DOI Listing
June 2019

Assessing the sedation effect of dexmedetomidine during hysteroscopic surgery.

J Clin Pharm Ther 2019 08 4;44(4):656. Epub 2019 Mar 4.

Department of Anesthesiology, The Affiliated Hospital of Guizhou Medical University, Guiyang, China.

View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1111/jcpt.12824DOI Listing
August 2019

Elevated circulating T cell subsets and cytokines expression in patients with rheumatoid arthritis.

Clin Rheumatol 2019 Jul 26;38(7):1831-1839. Epub 2019 Feb 26.

Department of Immunology and Rheumatology, The Third Affiliated Hospital of Guizhou Medical University, Guiyang, 550004, Guizhou Province, People's Republic of China.

Objective: This study aimed to assess the role of different subsets of circulating follicular helper T cells (Tfh), central memory (TCM), effector memory (TEM), Naïve T, chemokines, and cytokines in the pathogenesis of rheumatoid arthritis (RA).

Methods: Blood samples from RA patients (n = 44) and healthy controls (n = 37) were analyzed. The frequencies of circulating Tfh, TCM, TEM, and Naïve T cell subsets were enumerated, and the expression of co-stimulatory molecules, such as inducible co-stimulator (ICOS) and programmed death-1 (PD1), on these cells was evaluated by flow cytometry. The disease state in RA patients was assessed using the DAS28. Concentrations of C-reactive protein (CRP), erythrocyte sedimentation rate (ESR), anti-cyclic citrullinated peptide (anti-CCP), and rheumatoid factor (RF) were measured. Cytokines and chemokines, such as IL-1β, TNF-α, IL-4, IL-6, IL-9, IL-17A, MCP-1, IL-10, IL-12p70, and IL-21, were measured by a cytometric beads array assay.

Results: The percentages of circulating PD1ICOS Tfh, PD1ICOS TEM, and PD1ICOS TCM of PBMCs from RA patients were higher than those in healthy controls. Furthermore, expression of circulating PD1ICOS Tfh, PD1ICOS TEM, and PD1ICOS TCM showed a positive correlation with DAS28. In addition, increased levels of IL-1β, IL-6, and MCP-1 were detected in the patients with RA compared to healthy controls.

Conclusions: Elevated circulating T cell subsets and cytokines expression profile were observed in RA patients. IL-6, MCP-1, and IL-1β were significantly increased in RA, and PD1ICOS TEM, PD1ICOS TCM, and PD1ICOS Tfh cell subsets were positively correlated with disease activity DAS28. Therefore, PD1ICOS TEM, PD1ICOS TCM, and PD1ICOS Tfh cells might serve an important role in the progression of RA.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1007/s10067-019-04465-wDOI Listing
July 2019

Assessing the effect of dexmedetomidine in patients with pre-eclampsia.

Eur J Anaesthesiol 2019 01;36(1):75

From the Department of Anaesthesiology, The Affiliated Hospital of Guizhou Medical University, Guiyang, China (BH, XZ, JS), and Department of Clinical Research Centre, The Affiliated Hospital of Guizhou Medical University, Guiyang, China (HZ).

View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1097/EJA.0000000000000923DOI Listing
January 2019

The erector spinae plane block (ESPB) for non-intubated video-assisted thoracoscopic surgery.

J Clin Anesth 2019 May 2;54:50-51. Epub 2018 Nov 2.

Department of Anesthesiology, The Affiliated Hospital of Guizhou Medical University, No. 28 Guiyi Street, Yunyan District, 550004 Guiyang, China.

View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jclinane.2018.10.032DOI Listing
May 2019

Aberrant T cell subsets and cytokines expression profile in systemic lupus erythematosus.

Clin Rheumatol 2018 Sep 22;37(9):2405-2413. Epub 2018 May 22.

Key Lab of Endemic and Ethnic Diseases of the Ministry of Education of China in Guizhou Medical University, Guiyang, 550004, Guizhou Province, People's Republic of China.

To assess T cell subsets and levels of chemokines and cytokines in patients with SLE and determine their relationships between disease activity and organ involvement. Blood samples from SLE patients (n = 24) and healthy controls (n = 36) were analyzed. Frequency of circulating follicular help T cells (Tfh), central memory T cells (Tcm), effector memory T cells (Tem), and naïve T cell subsets was enumerated and their surface markers expression of inducible T cell co-stimulator (ICOS) and programmed death 1(PD-1) protein was examined by flow cytometry. The disease state in SLE patients was evaluated using the SLE Disease Activity Index (SLEDAI). Concentrations of autoantibodies, serum C-reactive protein (CRP), the erythrocyte sedimentation rate (ESR), lgG, complement 3, complement 4, cytokines, and chemokines, such as IL-21, IL-17A, and IL-1β, were measured. The frequencies of circulating Tfh and Tcm cell subsets were significantly lower than those in healthy controls. However, the percentages of circulating PD1ICOSTfh, PD1ICOSTcm, and PD1ICOSTem of PBMCs from SLE patients were higher than those in healthy controls. Furthermore, increased levels of serum IL-1β, IL-4, IL-6, MCP-1, IL-21, and IL-17A were detected in the patients with SLE compared to healthy controls. In addition, patients with immune thrombocytopenia displayed elevated proportions of serum IL-10, IL-17A, and IL-1β. Aberrant T cell subsets and cytokines expression profile were observed in SLE patients. PD1ICOSTem cell subset was clearly influenced by disease activity and serum IL-10, IL-17A, and IL-1β were significantly increased in patients with immune thrombocytopenia. Therefore, PD1ICOSTem cells might serve as an important tool for recognition and serum IL-10, IL-17A, and IL-1β might be an effective monitor for SLE patients with immune thrombocytopenia.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1007/s10067-018-4124-0DOI Listing
September 2018

Blind method regarding the effect of dexmedetomidine on CRBD.

J Anesth 2018 06 26;32(3):461. Epub 2018 Apr 26.

Department of Anesthesiology, The Affiliated Hospital of Guizhou Medical University, No. 28 Guiyi Street, Yunyan District, 550004, Guiyang, China.

View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1007/s00540-018-2497-5DOI Listing
June 2018

Comparison of the effect of high versus low mean arterial pressure levels on clinical outcomes and complications in elderly patients during non-cardiothoracic surgery under general anesthesia: study protocol for a randomized controlled trial.

Trials 2017 Nov 21;18(1):554. Epub 2017 Nov 21.

Clinical Medical Research Center, The Second Clinical Medicine College, Jinan University, Shenzhen, 518001, China.

Background: Intraoperative blood pressure (BP) is a concern in daily clinic anesthesia and contributes to the differences in clinical outcome. We conducted a randomized controlled trial (RCT) to compare the effect of high vs. low mean arterial pressure (MAP) levels on clinical outcomes and complications in elderly patients under general anesthesia (GA).

Methods: In this multicenter, randomized, parallel-controlled, open-label, assessor-blinded clinical trial, 322 patients aged more than 65 years will be randomized for a low-level MAP (60-70 mmHg) or high-level MAP (90-100 mmHg) during non-cardiothoracic surgery under GA. The primary outcome will be the incidence of postoperative delirium. The secondary outcomes will include the delirium duration days, intraoperative urine volume, intraoperative blood loss, specific postoperative complications, and all-cause 28-day mortality.

Discussion: Results of this trial will help clarify whether BP management is beneficial for elderly patients under GA and will make clear whether the effect of high-level MAP can reduce the postoperative complication compared to low-level MAP.

Trial Registration: ClinicalTrials.gov, NCT02857153 . Registered on 15 July 2016.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1186/s13063-017-2233-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5698923PMC
November 2017

Inhibition of GSK-3β Alleviates Collagen II-Induced Rheumatoid Arthritis in Rats.

Med Sci Monit 2016 Mar 31;22:1047-52. Epub 2016 Mar 31.

Department of Immunology and Rheumatology, The Affiliated Hospital of Guizhou Medical University, Guiyang, Guizhou, China (mainland).

Background: Glycogen synthase kinase-3β (GSK-3β) inhibitor is a serine/threonine kinase with an inhibitory role in glycogen synthesis, which is essential in inflammatory and immunological diseases. The purpose of our study was to determine if TDZD-8 can alleviate collagen II-induced rheumatoid arthritis in rats.

Material/methods: Twenty collagen II-induced rheumatoid arthritis rats were treated with selective GSK-3β inhibitor. The effects of GSK-3β inhibition on collagen II-induced rheumatoid arthritis in the rats were evaluated by paw edema, histological examination of arthritic synovium, radiographic examination of knee joint, and the level of inflammation mediators such as prostaglandin E2, 5-hydroxytryptamin, and histamine. The level of cytokines such as IL-6, IL-12, IL-10, and TNF-α, was examined by Elisa.

Results: GSK-3β inhibitor significantly reduced the development of rheumatoid arthritis in rats. The levels of inflammation mediators such as prostaglandin E2, 5-hydroxytryptamin, and histamine were decreased in the TDZD-8 group. Serum levels of IL-6, IL-12, and TNF-α were significantly reduced in the TDZD-8 group compared with the RA group.

Conclusions: Treatment with GSK-3β inhibitor suppressed inflammatory response in RA rats. These findings suggest that the inhibition of GSK-3β can be an effective treatment for RA.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4819688PMC
http://dx.doi.org/10.12659/msm.897739DOI Listing
March 2016

Confirmation of tracheal intubation time in adult patients.

J Anesth 2016 06 25;30(3):543. Epub 2015 Nov 25.

Department of Anesthesiology, West China Hospital, Sichuan University, Chengdu, 610041, China.

View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1007/s00540-015-2103-zDOI Listing
June 2016

Sensitivity and Specificity of a Novel Approach to Confirm the Depth of the Endotracheal Tube: A Pilot Study.

Medicine (Baltimore) 2015 Aug;94(34):e1460

From the Department of Anaesthesiology, West China Hospital, Sichuan University, Chengdu, Sichuan Province, 610041 (YL, YX, JW, BH, HS, XW); Department of Anaesthesiology, Northwest Women's and Children's Hospital, Xi'an, Shaanxi Province, 710000 (JW); Department of Anaesthesiology, Nanchong Central Hospital, Nanchong, Sichuan Province, 637000 (YX); and Department of Anaesthesiology, Affiliated hospital of Guiyang Medical College into Guizhou Medical University, Guiyang, Guizhou Province, 550001 (BH).

This study aimed to explore the sensitivity and specificity an approach to confirm the depth of the endotracheal tube. It was a prospective, diagnostic study (Registration number: chiCTR-TRC-14005170) conducted in the Department of Anesthesiology of West China Hospital. A total of 100 patients underwent general anesthesia were included. The distance between the upper margin of the cuff and the manubriosternal joint (CM) and the distance between the upper margin of the cuff and the carina (CC) were measured. The accuracy of the confirmed approach against fiberoptic bronchoscopy (FOB) was evaluated. Sensitivity, specificity, positive predictive value (PPV), and negative predictive value (NPV) were calculated. The correlation and agreement between CM and CC were explored.The sensitivity, specificity, positive predictive value (PPV), and negative predictive value (NPV) were determined to be 94.74% (95% CI: 87.07-98.55%), 79.17% (95% CI: 57.85-92.87%), 93.51% (95% CI: 85.49-97.86%), 82.61% (95% CI: 61.22%-95.05%), respectively. The κ value was 0.75 (95% CI: 0.60-0.90). There was a significant correlation between CM and CC (P < 0.001) with a correlation coefficient of 0.91(95% CI: 0.87-0.94). Bland and Altman plots also demonstrated a good agreement between the CM and CC. This novel method may be used to confirm the depth of the endotracheal tubes.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1097/MD.0000000000001460DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4602919PMC
August 2015
-->