Publications by authors named "Bahram Pourghasem Gargari"

5 Publications

  • Page 1 of 1

Oral administration of alpha-lipoic acid did not affect lipid peroxidation and antioxidant biomarkers in rheumatoid arthritis patients.

Int J Vitam Nutr Res 2019 Jul 21;89(1-2):13-21. Epub 2019 Feb 21.

5Drug Applied Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.

Rheumatoid arthritis (RA) is a chronic inflammatory disease in which oxidative stress could play a substantial pathological role. Alpha-lipoic acid (ALA) has been known as a "universal" and "ideal" antioxidant. The purpose of this study was to investigate the effects of oral administration of Alpha-lipoic acid (ALA) on lipid peroxidation and antioxidant biomarkers in Rheumatoid arthritis (RA) patients. The study was a randomized, double-blinded, placebo-controlled clinical trial. 70 RA patients were randomized 1:1 to two groups using blocked randomization method and received 1200 mg/day ALA or placebo for 8 weeks. Fasting blood samples were obtained before and after the intervention to analyze total antioxidant capacity (TAC), antioxidant enzymes [superoxide dismutase (SOD), glutathione peroxidase (GSH-Px) and arylesterase (ARE) activities] and malondialdehyde (MDA). We observed significant increase in serum TAC (0.11 mmol/L; p=0.033) and ARE (13.76 U/mL; p=0.046) and significant decline in MDA (-0.36 nmol/L; p=0.002), in ALA group. However, these changes in ALA-treated group were not statistically significant when compared with placebo-treated group (p > 0.05). Also, within- and between-group differences of whole blood SOD and GSH-Px were not statistically significant (p > 0.05). In conclusion, unexpectedly, ALA therapy did not affect the oxidative status of RA patients in the present clinical trial. It seems that more comprehensive clinical trials in RA patients are still warranted to clarify the effectiveness of ALA which has been known as a potent antioxidant.
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July 2019

Evaluation of changes in anthropometric indexes due to intermaxillary fixation following facial fractures.

J Dent Res Dent Clin Dent Prospects 2016 21;10(4):247-250. Epub 2016 Dec 21.

Department of Oral and Maxillofacial Surgery, Faculty of Dentistry, Tabriz University of Medical Sciences, Tabriz, Iran.

One of the treatment modalities for facial fractures is closed reduction technique, but treatment with intermaxillary fixation (IMF) interferes with normal nutrition, and malnutrition can affect the patient's recovery. Anthropometric measurements such as skinfold thickness and body mass index (BMI) are universal indexes for diagnosing malnutrition. Therefore, in this study we explain how treatment with IMF changes the anthropometric indexes. In this study 60 patients were treated with 4 weeks of IMF. Skinfold thickness and BMI of these patients were measured and compared before and after the treatment. Patients' weight, BMI and skinfold thickness decreased during the IMF period, and this decrease was statistically significant (P < 0.01). Although no severe and acute malnutrition was seen among our patients, IMF led to mild to moderate malnutrition in some cases, making it necessary to use nutritional supplements.
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December 2016

Central obesity and coronary heart disease risk factors in referral outpatients to zahedan cardiology clinic, iran.

Int J High Risk Behav Addict 2012 25;1(2):79-83. Epub 2012 Jul 25.

Department of Neurology, Faculty of Medicine, Zahedan University of Medical Sciences, Zahedan, IR Iran.

Background: Coronary Heart Disease (CHD) is one of the most common and life-threatening diseases in both developed and developing countries and a close correlation has been found between different types of obesity and CHD.

Objectives: The current study investigated the relationship between central obesity and coronary heart disease risk factors in CHD referral outpatients to Khatam Clinic, Zahedan, Iran.

Patients And Methods: In this clinical, cross-sectional study, data for 120 CHD patients aged 30-60 years were included. Based on waist-to-hip ratio (WHR), subjects were classified into two groups: not centrally obese (NCO; WHR ≤ 0.95 for men, ≤ 0.8 for women) and centrally obese (CO; WHR > 0.95 and > 0.8 for men and women, respectively). Triglyceride (TG), total cholesterol (TC), blood urea nitrogen, creatinine, and fasting blood sugar (FBS) were enzymatically determined. Sitting systolic and diastolic blood pressures were measured for each patient.

Results: Significantly more women than men and significantly more subjects with less education than subjects with more education were CO. Rates of CO were higher in subjects 45-60 years old than in those 30-45 years old (n.s.). CO subjects also had higher mean systolic and diastolic blood pressure, TG, and creatinine levels (n.s.). Significantly higher mean values were observed for FBS in CO subjects than in NCO subjects (P = 0.02). Mean values for smoking were significantly higher in the NCO group compared with the CO group (P = 0.004).

Conclusions: According to the results of this study, in CHD patients, central obesity was associated with certain risk factors, especially FBS. Central obesity was more evident in women, less educated subjects, and older subjects. Further research is required to clarify these associations.
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June 2014

Impact of prophylactic iron supplementation in healthy pregnant women on maternal iron status and birth outcome.

Food Nutr Bull 2011 Sep;32(3):213-7

Lorestan University of Medical Sciences, Khorramabad, Iran.

Background: In spite of the beneficial effect of iron supplementation in iron-deficient pregnant women, iron supplementation may not be needed for women who are iron replete or not anemic. Moreover, the theoretical possibility of adverse effects, such as oxidative damage,from administration of iron supplements during pregnancy has been raised.

Objective: To determine the effect of prophylactic iron supplementation on iron status and birth outcomes among nonanemic pregnant women. METHODS. A randomized, triple-blind clinical trial was conducted. One hundred forty-eight nonanemic pregnant women with hemoglobin > 110 g/L, serum ferritin > 12 microg/L, and gestational age < 20 weeks were randomly assigned to receive either ferrous sulfate (60 mg elemental iron) (n = 70) or placebo (n = 78) until delivery. Hemoglobin concentration and serum ferritin were measured by electronic counter and radioimmunoassay, respectively. Data were analyzed by independent t-tests, ANCOVA, and repeated measures.

Results: At delivery, the incidence of iron deficiency was significantly lower in the iron than in the placebo group. There were no significant differences between the two groups in maternal hemoglobin and ferritin concentrations at delivery or in the infant's birthweight, birth length, or length of gestation.

Conclusions: Iron supplementation during pregnancy in nonanemic women with low serum ferritin may have benefits beyond the prevention of iron-deficiency anemia.
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September 2011

The effect of hypocaloric diet enriched in legumes with or without L-arginine and selenium on anthropometric measures in central obese women.

J Res Med Sci 2010 Nov;15(6):331-43

Student Research Committee, Tabriz University of Medical Sciences, Tabriz, Iran.

Background: Identifying new ways to decrease adiposity will be very valuable for health. The aim of this study was to find out whether L-Arginine (Arg) and selenium alone or together can increase the effect of hypocaloric diet enriched in legumes (HDEL) on anthropometric measures in healthy obese women.

Methods: This randomized, double-blind, placebo-controlled trial was undertaken in 84 healthy premenopausal women with central obesity. After 2 weeks of run-in on an isocaloric diet, participants were randomly considered to eat HDEL, Arg (5 g/d) and HDEL, selenium (200 µg/d) and HDEL or Arg, selenium and HDEL for 6 weeks. The following variables were assessed before intervention and 3 and 6 weeks after it: weight, waist circumference, hip circumference, waist to hip ratio (WHR), body mass index (BMI), and fasting nitrite/nitrate (NO(x)) concentrations. Other variables (arm, thigh, calf and breast circumferences, subscapular, triceps, biceps and suprailiac skinfold thicknesses, sum of skinfold thicknesses (SSF), body density (D) and estimated percent of body fat (EPF)) were assessed before and after intervention.

Results: HDEL showed a significant effect in reduction of waist, hip, arm, thigh, calf and breast circumferences, triceps, biceps, subscapular and suprailiac skinfold thicknesses, WHR, SSF, D and EPF. HDEL + Arg + selenium significantly reduced suprailiac skinfold thicknesses; and there was no significant effect of HDEL, Arg, selenium and Arg plus selenium on weight, BMI and fasting NO(x).

Conclusions: The study indicates that HDEL + Arg + selenium reduce suprailiac skinfold thicknesses which represents the abdominal obesity reduction.
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November 2010