Bahman Sadeghi - University of Tehran - Research Assistant

Bahman Sadeghi

University of Tehran

Research Assistant

Tehran | Iran (Islamic Republic of)

Main Specialties: Addiction Psychiatry, Biology, Clinical Neurophysiology, Neurology, Neuropathology, Neuroradiology, Pharmacology

Additional Specialties: Neuroscience

ORCID logohttps://orcid.org/0000-0002-9248-5804

Bahman Sadeghi - University of Tehran - Research Assistant

Bahman Sadeghi

Introduction

Bahman Sadeghi currently works as a research assistant at the Institute of Biochemistry and Biophysics (IBB), University of Tehran.
*Other affiliations: 1) Dept Physiology, School of Allied Medical Sciences, Shahid Beheshti University of Medical Sciences 2) Neuroscience Research Center, SBMU. Bahman does research in Cognitive Science, Biological Psychology and Neuropharmacology.
*Main research interests: 1) Learning & memory deficits in neurodegeneration (AD) 2) Developing tools & protocols to study high-level sensorimotor processing 3) Reward & pain circuitry: molecular architecture & signaling in cortex 4) Machine learning & deep learning 5) Neuroinformatics & systems neuroscience 6) Psychophysics / Attention / Perception and Computational neuroscience 7) Neuropharmacology of atypical antipsychotics (in SCZ-related suicide, etc.) 8) Visuotopy, retinotopy, somatotopy, somatosensory cortices’ spatial/field 9) Neurobiology of psychiatric & affective disorders, etc.
*Interested techniques: Electrophysiology (Extracellular Single Unit Recording, Local Field Potential Recording), Optogenetics, Neuroimaging (fMRI, SPECT, FNIRS, MEG, and Multi-photon laser imaging), Patch clamp, Behavioral paradigms (Rodent, monkey, and human reward and learning tasks: CPP, PAL, Decision-making mazes, Iowa Gambling Task, etc.)

Google Scholar: https://scholar.google.com/citations?user=6tL9DV8AAAAJ&hl=en&oi=ao

Primary Affiliation: University of Tehran - Tehran , Iran (Islamic Republic of)

Specialties:

Additional Specialties:

Research Interests:

Education

Feb 2014
University of Tehran

Experience

May 2013
Shahid Beheshti University of Medical Sciences
Researcher
Neuroscience, Neurophysiology, Electrophysiology, Biological Psychiatry, Alzheimer
Apr 2010
University of Tehran
Researcher
Biological psychology, Biochemistry, Biology, Microtubules, Tauopathy, Alzheimer's disease, ...

Publications

8Publications

268Reads

5Profile Views

Nucleus basalis of Meynert modulates signal processing in rat layer 5 somatosensory cortex but leads to memory impairment and tactile discrimination deficits following lesion.

Behav Brain Res 2020 May 16;386:112608. Epub 2020 Mar 16.

Department of Physiology, School of Allied Medical Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran; Department of Biochemistry, Institute of Biochemistry and Biophysics (IBB), University of Tehran, Tehran, Iran. Electronic address:

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http://dx.doi.org/10.1016/j.bbr.2020.112608DOI Listing
May 2020
3.028 Impact Factor

Nucleus basalis of Meynert modulates signal processing in rat layer 5 somatosensory cortex but leads to memory impairment and tactile discrimination deficits following lesion

Behavioural Brain Research

In rodents, exploring through continuous whisking is a process resulted from sensorimotor networking among different layers of somatosensory cortex (SC) such as layer 5 (L5) or barrel field, and regions like the nucleus basalis of Meynert (NBM). NBM is densely packed with cholinergic fibers and its dysfunction leads to diminished acetylcholine release within SC, tactile deficits and Alzheimer’s disease (AD)-like memory impairment. Using extracellular single-unit recording, we investigated mechanisms underlying changes in response characteristics of L5b neurons to single or paired deflection of selected principle and adjacent whiskers (PW and AW), following NBM electrical stimulation in normal rats or ibotenic acid-induced NBM lesion leading to potential tactile deficiency and memory loss during passive avoidance learning (PAL) in AD-like neuropathology. Our results indicated that NBM electrical stimulation decreased ON and OFF response magnitude in nearly half of the units upon vibrissal deflection. The larger the response was evoked to whisker deflection before NBM stimulation, the smaller it gets after stimulation. Neuronal spontaneous activity was not changed with NBM stimulation or lesion. Leading to more sublinear response summation and decreased condition-test ratio, NBM lesion decreased ON response magnitude and facilitation, increased AW surround inhibition in paired whisker deflection, increased excitatory and decreased inhibitory receptive fields, weakened information processing during whisking, and resulted in AD-like declined PAL performance. These findings provide further understandings to develop translational approaches in precision therapeutics to target highly specific regions such as NBM or SC, and pathways like cholinergic system involved in tactile and memory deficits in AD.

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March 2020
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Oxytocin moderates risky decision-making during the Iowa Gambling Task: A new insight based on the role of oxytocin receptor gene polymorphisms and interventional cognitive study.

Neurosci Lett 2019 08 11;708:134328. Epub 2019 Jun 11.

Research Center for Addiction and Risky Behavior (ReCARB), Iran University of Medical Sciences (IUMS), Tehran, Iran. Electronic address:

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http://dx.doi.org/10.1016/j.neulet.2019.134328DOI Listing
August 2019
1 Read
2.055 Impact Factor

Chronic ghrelin administration restores hippocampal long-term potentiation and ameliorates memory impairment in rat model of Alzheimer's disease.

Hippocampus 2018 10 5;28(10):724-734. Epub 2018 Sep 5.

Department of Physiology, School of Allied Medical Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

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http://dx.doi.org/10.1002/hipo.23002DOI Listing
October 2018
226 Reads
4.162 Impact Factor

Involvement of cannabinoid system in the nucleus accumbens on delay-based decision making in the rat.

Behav Brain Res 2018 Jan 5;337:107-113. Epub 2017 Oct 5.

Neuroscience Research Center, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran; Iran National Science Foundation, Tehran, Iran. Electronic address:

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http://dx.doi.org/10.1016/j.bbr.2017.10.004DOI Listing
January 2018
1 Read
3.028 Impact Factor

Effects of dorsal hippocampal orexin-2 receptor antagonism on the acquisition, expression, and extinction of morphine-induced place preference in rats.

Psychopharmacology (Berl) 2016 06 6;233(12):2329-41. Epub 2016 Apr 6.

Neuroscience Research Center, School of Medicine, Shahid Beheshti University of Medical Sciences, P. O. Box 19615-1178, Tehran, Iran.

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http://dx.doi.org/10.1007/s00213-016-4280-3DOI Listing
June 2016
1 Read
3.875 Impact Factor

Chronic administration of ghrelin regulates plasma glucose and normalizes insulin levels following fasting hyperglycemia and hyperinsulinemia.

Gen Comp Endocrinol 2015 Dec 6;224:113-20. Epub 2015 Jul 6.

Department of Physiology, School of Allied Medical Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran; Neuroscience Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S00166480150018
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http://dx.doi.org/10.1016/j.ygcen.2015.07.001DOI Listing
December 2015
2 Reads
2.470 Impact Factor

Chemical stimulation of the lateral hypothalamus by carbachol attenuated the formalin-induced pain behaviors in rats.

Pharmacol Biochem Behav 2015 Feb 2;129:105-10. Epub 2015 Jan 2.

Neuroscience Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S00913057140035
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http://dx.doi.org/10.1016/j.pbb.2014.12.012DOI Listing
February 2015
37 Reads
2.781 Impact Factor

Top co-authors

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Shahid Beheshti University of Medical Sciences

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Islamic AZAD University

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Islamic Azad University

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Iran University of Medical Sciences

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