Bahman Sadeghi currently works as a research assistant at the Institute of Biochemistry and Biophysics (IBB), University of Tehran.
*Other affiliations: 1) Dept Physiology, School of Allied Medical Sciences, Shahid Beheshti University of Medical Sciences 2) Neuroscience Research Center, SBMU. Bahman does research in Cognitive Science, Biological Psychology and Neuropharmacology.
*Main research interests: 1) Learning & memory deficits in neurodegeneration (AD) 2) Developing tools & protocols to study high-level sensorimotor processing 3) Reward & pain circuitry: molecular architecture & signaling in cortex 4) Machine learning & deep learning 5) Neuroinformatics & systems neuroscience 6) Psychophysics / Attention / Perception and Computational neuroscience 7) Neuropharmacology of atypical antipsychotics (in SCZ-related suicide, etc.) 8) Visuotopy, retinotopy, somatotopy, somatosensory cortices’ spatial/field 9) Neurobiology of psychiatric & affective disorders, etc.
*Interested techniques: Electrophysiology (Extracellular Single Unit Recording, Local Field Potential Recording), Optogenetics, Neuroimaging (fMRI, SPECT, FNIRS, MEG, and Multi-photon laser imaging), Patch clamp, Behavioral paradigms (Rodent, monkey, and human reward and learning tasks: CPP, PAL, Decision-making mazes, Iowa Gambling Task, etc.)
Google Scholar: https://scholar.google.com/citations?user=6tL9DV8AAAAJ&hl=en&oi=ao
Primary Affiliation: University of Tehran - Tehran , Iran (Islamic Republic of)
Behav Brain Res 2020 May 16;386:112608. Epub 2020 Mar 16.
Department of Physiology, School of Allied Medical Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran; Department of Biochemistry, Institute of Biochemistry and Biophysics (IBB), University of Tehran, Tehran, Iran. Electronic address:
In rodents, exploring through continuous whisking is a process resulted from sensorimotor networking among different layers of somatosensory cortex (SC) such as layer 5 (L5) or barrel field, and regions like the nucleus basalis of Meynert (NBM). NBM is densely packed with cholinergic fibers and its dysfunction leads to diminished acetylcholine release within SC, tactile deficits and Alzheimer’s disease (AD)-like memory impairment. Using extracellular single-unit recording, we investigated mechanisms underlying changes in response characteristics of L5b neurons to single or paired deflection of selected principle and adjacent whiskers (PW and AW), following NBM electrical stimulation in normal rats or ibotenic acid-induced NBM lesion leading to potential tactile deficiency and memory loss during passive avoidance learning (PAL) in AD-like neuropathology. Our results indicated that NBM electrical stimulation decreased ON and OFF response magnitude in nearly half of the units upon vibrissal deflection. The larger the response was evoked to whisker deflection before NBM stimulation, the smaller it gets after stimulation. Neuronal spontaneous activity was not changed with NBM stimulation or lesion. Leading to more sublinear response summation and decreased condition-test ratio, NBM lesion decreased ON response magnitude and facilitation, increased AW surround inhibition in paired whisker deflection, increased excitatory and decreased inhibitory receptive fields, weakened information processing during whisking, and resulted in AD-like declined PAL performance. These findings provide further understandings to develop translational approaches in precision therapeutics to target highly specific regions such as NBM or SC, and pathways like cholinergic system involved in tactile and memory deficits in AD.
Gen Comp Endocrinol 2015 Dec 6;224:113-20. Epub 2015 Jul 6.
Department of Physiology, School of Allied Medical Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran; Neuroscience Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran. Electronic address: