Badry Bursulaya

Badry Bursulaya

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Badry Bursulaya

Badry Bursulaya

Publications by authors named "Badry Bursulaya"

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45Publications

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Tuning a Protein-Labeling Reaction to Achieve Highly Site Selective Lysine Conjugation.

Chembiochem 2018 04 15;19(8):799-804. Epub 2018 Mar 15.

Genomics Institute of the Novartis Research Foundation (GNF), Biotherapeutics & Biotechnology, 10675 John Jay Hopkins Drive, San Diego, CA, 92121, USA.

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http://doi.wiley.com/10.1002/cbic.201700611
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http://dx.doi.org/10.1002/cbic.201700611DOI Listing
April 2018

Design and synthesis of novel selective anaplastic lymphoma kinase inhibitors.

Bioorg Med Chem Lett 2016 Feb 17;26(3):1090-1096. Epub 2015 Nov 17.

Novartis Institutes for BioMedical Research, Inc., 250 Massachusetts Avenue, Cambridge, MA 02139, United States.

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http://dx.doi.org/10.1016/j.bmcl.2015.11.049DOI Listing
February 2016

Site-specific dual labeling of proteins by using small orthogonal tags at neutral pH.

Chembiochem 2014 Aug 17;15(12):1787-91. Epub 2014 Jul 17.

Genomics Institute of the Novartis Research Foundation, 10675 John-Jay-Hopkins Drive, San Diego, CA 92121 (USA).

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http://dx.doi.org/10.1002/cbic.201402204DOI Listing
August 2014

Discovery of trifluoromethyl(pyrimidin-2-yl)azetidine-2-carboxamides as potent, orally bioavailable TGR5 (GPBAR1) agonists: structure-activity relationships, lead optimization, and chronic in vivo efficacy.

J Med Chem 2014 Apr 4;57(8):3263-82. Epub 2014 Apr 4.

Departments of †Medicinal Chemistry, ‡Drug Discovery Biology, §Pharmacology, ∥Pharmacokinetics, and ⊥Structural Biology, Genomics Institute of the Novartis Research Foundation , 10675 John Jay Hopkins Drive, San Diego, California 92121, United States.

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http://dx.doi.org/10.1021/jm401731qDOI Listing
April 2014

Structural basis for lack of toxicity of the diphtheria toxin mutant CRM197.

Proc Natl Acad Sci U S A 2012 Apr 19;109(14):5229-34. Epub 2012 Mar 19.

Genomics Institute of the Novartis Research Foundation, 10675 John Jay Hopkins Drive, San Diego, CA 92121, USA.

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http://dx.doi.org/10.1073/pnas.1201964109DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3325714PMC
April 2012

A chemical genomic analysis of decoquinate, a Plasmodium falciparum cytochrome b inhibitor.

ACS Chem Biol 2011 Nov 8;6(11):1214-22. Epub 2011 Sep 8.

Department of Chemistry, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, California 92037, United States.

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http://dx.doi.org/10.1021/cb200105dDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3220786PMC
November 2011

Expanding the diversity of allosteric bcr-abl inhibitors.

J Med Chem 2010 Oct;53(19):6934-46

Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, Massachusetts 02115, USA.

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http://dx.doi.org/10.1021/jm100555fDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2951064PMC
October 2010

Temperature-induced opening of TRPV1 ion channel is stabilized by the pore domain.

Nat Neurosci 2010 Jun 22;13(6):708-14. Epub 2010 Apr 22.

Department of Cell Biology, Scripps Research Institute, La Jolla, California, USA.

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http://dx.doi.org/10.1038/nn.2552DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2876202PMC
June 2010

Divalent cations slow activation of EAG family K+ channels through direct binding to S4.

Biophys J 2009 Jul;97(1):110-20

Department of Cell Biology, Institute for Childhood and Neglected Diseases, The Scripps Research Institute, La Jolla, California 92037, USA.

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http://dx.doi.org/10.1016/j.bpj.2009.04.032DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2711382PMC
July 2009

Active site conformational changes of prostasin provide a new mechanism of protease regulation by divalent cations.

Protein Sci 2009 May;18(5):1081-94

Genomics Institute of the Novartis Research Foundation, 10675 John Jay Hopkins Drive, San Diego, California 92121, USA.

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http://dx.doi.org/10.1002/pro.118DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2771310PMC
May 2009

Golgicide A reveals essential roles for GBF1 in Golgi assembly and function.

Nat Chem Biol 2009 Mar 1;5(3):157-65. Epub 2009 Feb 1.

Department of Pediatrics, Washington University School of Medicine, 660 S. Euclid Ave., St. Louis, Missouri 63110, USA.

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http://dx.doi.org/10.1038/nchembio.144DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3500152PMC
March 2009

Discovery of inhibitors of the channel-activating protease prostasin (CAP1/PRSS8) utilizing structure-based design.

Bioorg Med Chem Lett 2008 Nov 14;18(22):5895-9. Epub 2008 Aug 14.

Genomics Institute of the Novartis Research Foundation, 10675 John J. Hopkins Dr., San Diego, CA 92121, USA.

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http://dx.doi.org/10.1016/j.bmcl.2008.08.029DOI Listing
November 2008

Pore region of TRPV3 ion channel is specifically required for heat activation.

Nat Neurosci 2008 Sep;11(9):1007-13

Department of Cell Biology, The Scripps Research Institute, La Jolla, California 92037, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2685190PMC
http://dx.doi.org/10.1038/nn.2169DOI Listing
September 2008

Verification of a designed intramolecular hydrogen bond in a drug scaffold by nuclear magnetic resonance spectroscopy.

J Med Chem 2007 Nov 2;50(24):5875-7. Epub 2007 Nov 2.

Genomics Institute of the Novartis Research Foundation, 10675 John Jay Hopkins Drive, San Diego, CA 92121, USA.

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http://dx.doi.org/10.1021/jm700983aDOI Listing
November 2007

Bicyclic carbamates as inhibitors of papain-like cathepsin proteases.

Bioorg Med Chem Lett 2007 Mar 9;17(5):1254-9. Epub 2006 Dec 9.

Department of Drug Discovery, The Genomics Institute of the Novartis Research Foundation, 10675 John Jay Hopkins Drive, San Diego, CA 92121, USA.

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http://dx.doi.org/10.1016/j.bmcl.2006.12.014DOI Listing
March 2007

3,4,5-Trisubstituted isoxazoles as novel PPARdelta agonists. Part 2.

Bioorg Med Chem Lett 2006 Nov 22;16(21):5488-92. Epub 2006 Aug 22.

Department of Medicinal Chemistry, The Genomics Institute of the Novartis Research Foundation, 10675 John Jay Hopkins Drive, San Diego, CA 92121, USA.

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http://dx.doi.org/10.1016/j.bmcl.2006.08.052DOI Listing
November 2006

Synthesis and biological evaluations of sulfanyltriazoles as novel HIV-1 non-nucleoside reverse transcriptase inhibitors.

Bioorg Med Chem Lett 2006 Aug 14;16(16):4174-7. Epub 2006 Jun 14.

Genomics Institute of the Novartis Research Foundation (GNF), San Diego, CA 92121, USA.

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http://linkinghub.elsevier.com/retrieve/pii/S0960894X0600641
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http://dx.doi.org/10.1016/j.bmcl.2006.05.096DOI Listing
August 2006

Design, synthesis, and biological evaluations of novel quinolones as HIV-1 non-nucleoside reverse transcriptase inhibitors.

Bioorg Med Chem Lett 2006 Aug 16;16(16):4246-51. Epub 2006 Jun 16.

Genomics Institute of the Novartis Research Foundation (GNF), San Diego, CA 92121, USA.

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http://dx.doi.org/10.1016/j.bmcl.2006.05.073DOI Listing
August 2006

1,3,5-Trisubstituted aryls as highly selective PPARdelta agonists.

Bioorg Med Chem Lett 2006 Jun 20;16(11):2969-73. Epub 2006 Mar 20.

Department of Medicinal Chemistry, The Genomics Institute of the Novartis Research Foundation, 10675 John Jay Hopkins Drive, San Diego, CA 92121, USA.

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http://dx.doi.org/10.1016/j.bmcl.2006.02.079DOI Listing
June 2006

Design, synthesis, and biological evaluations of novel oxindoles as HIV-1 non-nucleoside reverse transcriptase inhibitors. Part 2.

Bioorg Med Chem Lett 2006 Apr 7;16(8):2109-12. Epub 2006 Feb 7.

Genomics Institute of the Novartis Research Foundation (GNF), 10715 John Jay Hopkins Drive, San Diego, CA 92121, USA.

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http://dx.doi.org/10.1016/j.bmcl.2006.01.066DOI Listing
April 2006

Design, synthesis and biological evaluations of novel oxindoles as HIV-1 non-nucleoside reverse transcriptase inhibitors. Part I.

Bioorg Med Chem Lett 2006 Apr 9;16(8):2105-8. Epub 2006 Feb 9.

Genomics Institute of the Novartis Research Foundation (GNF), 10675 John Jay Hopkins Drive, San Diego, CA 92121, USA.

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http://dx.doi.org/10.1016/j.bmcl.2006.01.073DOI Listing
April 2006

Design and synthesis of arylaminoethyl amides as noncovalent inhibitors of cathepsin S. Part 1.

Bioorg Med Chem Lett 2005 Nov 23;15(22):4979-84. Epub 2005 Sep 23.

Genomics Institute of the Novartis Research Foundation, 10675 John J. Hopkins Dr., San Diego, CA 92121, USA.

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http://dx.doi.org/10.1016/j.bmcl.2005.08.017DOI Listing
November 2005

Selective incorporation of 5-hydroxytryptophan into proteins in mammalian cells.

Proc Natl Acad Sci U S A 2004 Jun 8;101(24):8882-7. Epub 2004 Jun 8.

Department of Chemistry, The Scripps Research Institute, La Jolla, CA 92037, USA.

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http://dx.doi.org/10.1073/pnas.0307029101DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC428441PMC
June 2004

Identification of novel potent bicyclic peptide deformylase inhibitors.

Bioorg Med Chem Lett 2004 Mar;14(6):1477-81

Genomics Institute of the Novartis Research Foundation, 10675 John Jay Hopkins Drive, San Diego, CA 92121, USA.

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http://dx.doi.org/10.1016/j.bmcl.2004.01.014DOI Listing
March 2004

Comparative study of several algorithms for flexible ligand docking.

J Comput Aided Mol Des 2003 Nov;17(11):755-63

Department of Molecular Biology (TPC6), The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA.

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http://dx.doi.org/10.1023/b:jcam.0000017496.76572.6fDOI Listing
November 2003

Development and characterization of nonpeptidic small molecule inhibitors of the XIAP/caspase-3 interaction.

Chem Biol 2003 Aug;10(8):759-67

The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA.

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http://dx.doi.org/10.1016/s1074-5521(03)00157-1DOI Listing
August 2003