Publications by authors named "B Li"

28,668 Publications

Reducing particulates in indoor air can improve the circulation and cardiorespiratory health of old people: A randomized, double-blind crossover trial of air filtration.

Sci Total Environ 2021 Jul 23;798:149248. Epub 2021 Jul 23.

Joint International Research Laboratory of Green Buildings and Built Environments (Ministry of Education), Chongqing University, Chongqing 400045, China; National Centre for International Research of Low-carbon and Green Buildings (Ministry of Science and Technology), Chongqing University, Chongqing, China. Electronic address:

Exposure to indoor air particulate pollution increases respiratory and cardiovascular morbidity and mortality, especially in the elderly. To assess a short-term, indoor air filtration's potential benefit on circulatory and cardiopulmonary health among healthy older people, a randomized, double-blind crossover trial was conducted with 24 healthy residents of an aged-care center in Chongqing, China in 2020. Each room received a high-efficiency particulate air filter air purifier and a placebo air purifier for two days. Fifteen circulatory system biomarkers of inflammation, coagulation, and oxidative stress; lung function; blood pressure (BP); heart rate (HR) and fractional exhaled nitric oxide (FeNO) were measured end of each two days. Indoor air particulate pollution was monitored throughout the study period. Linear mixed-effect models were used to associate health outcome variables with indoor particles. This intervention study demonstrated that air filtration was associated with significantly decreased concentrations of inflammatory and coagulation biomarkers, but not of biomarkers of oxidative stress and lung function. Just 48 h of air filtration can improve the cardiopulmonary health of the elderly. Air purifiers may be a public health measure that can be taken to improve circulatory and cardiopulmonary health among older people.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.scitotenv.2021.149248DOI Listing
July 2021

Three dimensionally printed nitrocellulose-based microfluidic platform for investigating the effect of oxygen gradient on cells.

Analyst 2021 Jul 29. Epub 2021 Jul 29.

CAS Key Laboratory of Coastal Environment Processes and Ecological Remediation, The Research Center for Coastal Environment Engineering and Technology, Yantai Institute of Coastal Zone Research, Chinese Academy of Sciences, Yantai 264003, China. and Center for Ocean Mega-Science, Chinese Academy of Sciences, Qingdao 266071, China.

In this article, we present a novel nitrocellulose-based microfluidic chip with 3-dimensional (3D) printing technology to study the effect of oxygen gradient on cells. Compared with conventional polydimethylsiloxane (PDMS) chips of oxygen gradient for cell cultures that can only rely on fluorescence microscope analysis, this hybrid nitrocellulose-based microfluidic platform can provide a variety of analysis methods for cells, including flow cytometry, western blot and RT-PCR, because the nitrocellulose-based chips with cells can be taken out from the growth chambers of 3D printed microfluidic chip and then used for cell collection or lysis. These advantages allow researchers to acquire more information and data on the basic biochemical and physiological processes of cell life. The effect of oxygen gradient on the zebrafish cells (ZF4) was used as a model to show the performance and application of our platform. Hypoxia caused the increase of intercellular reactive oxygen species (ROS) and accumulation of hypoxia-inducible factor 1α (HIF-1α). Hypoxia stimulated the transcription of hypoxia-responsive genes vascular endothelial growth factor (VEGF) and induced cell cycle arrest of ZF4 cells. The established platform is able to obtain more information from cells in response to different oxygen concentration, which has potential for analyzing the cells under a variety of pathological conditions.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1039/d1an00927cDOI Listing
July 2021

Emotions in Deaf and Hard-of-Hearing and Typically Hearing Children.

J Deaf Stud Deaf Educ 2021 Jul 29. Epub 2021 Jul 29.

Unit of Developmental and Educational Psychology, Institute of Psychology, Leiden University, Leiden, The Netherlands.

For deaf and hard-of-hearing (DHH) children living in an environment where their access to linguistic input and social interactions is compromised, learning emotions could be difficult, which may further affect social functioning. To understand the role of emotion in DHH children's social life, this study investigated emotional functioning (i.e., emotion recognition, empathy, emotion expression), and its relation with social functioning (i.e., social competence and externalizing behaviors), in 55 DHH children and 74 children with typical hearing (aged 3-10 years; Mage = 6.04). Parental reports on children's emotional and social functioning and factors related to DHH children's hearing were collected. Results showed similar levels of emotional and social functioning in children with and without hearing loss. Use of auditory intervention and speech perception did not correlate with any measures in DHH children. In both groups, higher levels of empathy related to higher social competence and fewer externalizing behaviors; emotion recognition and positive emotion expression were unrelated to either aspect of social functioning. Higher levels of negative emotion expression related to lower social competence in both groups, but to more externalizing behaviors in DHH children only. DHH children in less linguistically accessible environments may not have adequate knowledge for appropriately expressing negative emotions socially.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1093/deafed/enab022DOI Listing
July 2021

Spatiotemporal distribution of atmospheric polycyclic aromatic hydrocarbon emissions during 2013-2017 in mainland China.

Sci Total Environ 2021 May 24;789:148003. Epub 2021 May 24.

Co-Innovation Center for Sustainable Forestry in Southern China, College of Forestry, Nanjing Forestry University, Nanjing 210037, China.

Following implementation of the most stringent clean air policy in China, the emissions of NOx, SO, and fine particles have greatly reduced since 2013. However, the emissions of polycyclic aromatic hydrocarbons (PAHs), which are highly toxic pollutants, and their spatiotemporal changes remain unclear. In this study, a 0.05° × 0.05° gridded PAH emission inventory was developed for mainland China during 2013-2017. The results show that the total PAH emissions have decreased from 112.92 Gg in 2013 to 100.09 Gg in 2017, with the fastest declines in the industrial (17.32%) and residential/commercial (10.58%) sectors. However, the decline in the PAH emissions is smaller than that of the NO and SO emissions. The average emission density of PAHs in mainland China in 2017 was 10.43 kg/km. North and East China have the largest PAH emissions. The residential/commercial, industrial, and transportation sectors are the major emission sources, accounting for 48.59%, 29.26%, and 17.21%, respectively. Carcinogenic PAH emissions accounted for 7.49% in mainland China, higher than those of developed countries (5.73%) and the global average (6.19%). Differences in the energy structures lead to significant differences in the spatial distribution of PAH emissions in various sectors. From 2013 to 2017, the emissions declined in most Chinese regions. The emission density in East China decreased the most, reaching 3.39 kg/km, followed by North China (2.91 kg/km). The magnitude of the decline in the PAH emissions and reasons for the decline significantly differ in different regions. Particular attention must be paid to the limited decline (5.22%) in Northwest China over the study period. Although China's emission density has been declining, it is still significantly higher than the global average. Therefore, China must further reduce the PAH emissions through technological innovation and reductions of energy consumption and, thus, reduce the regional lung cancer risk.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.scitotenv.2021.148003DOI Listing
May 2021

Visualizing and evaluating mitochondrial cysteine via near-infrared fluorescence imaging in cells, tissues and in vivo under hypoxia/reperfusion stress.

J Hazard Mater 2021 Jun 25;419:126476. Epub 2021 Jun 25.

CAS Key Laboratory of Coastal Environmental Processes and Ecological Remediation, Shandong Key Laboratory of Coastal Environmental Processes, Yantai Institute of Coastal Zone Research, Chinese Academy of Sciences, Yantai 264003, China; Laboratory for Marine Biology and Biotechnology, Pilot National Laboratory for Marine Science and Technology, Qingdao 266237, China; Center for Ocean Mega-Science, Chinese Academy of Sciences, Qingdao 266071, China. Electronic address:

Increasingly grim environmental pollutions are closely related with the occurrence and development of diseases. However, it's obscure how environmental stress disturbs the normal physiological process, and then how endogenous reactive species mend the cases. Hypoxia/reperfusion (H/R), a common and intractable injury in aquaculture and clinic, can induce oxidative stress and ultimately cause irreversible injury to organism. Cysteine (Cys) plays essential roles in maintaining transduction of numerous reactive species and redox homeostasis in subcellular structures, cells and organisms. A great deal of fluorescence research about Cys are focusing on development of selective probes but with poor exploration of the biofunction under environmental stress. Therefore, it is of great significance to examine the bio-effects of Cys against H/R stress. In the present work, we design a fluorescent probe BCy-AC for in situ detecting Cys, the unique Enol-Keto tautomerization of fluorophore BCy-Keto propels the reaction process which will improve the sensitivity and potential application performance of the probe. BCy-AC is conveniently applied to visualize Cys in HT-22 cells, zebrafish and mice tissues. Moreover, imaging results obtained from H/R models reveal that endogenous Cys changes with hypoxia and reperfusion time and Cys pretreatment effectively defend H/R injury in cells and in vivo.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jhazmat.2021.126476DOI Listing
June 2021
-->