Publications by authors named "B Harshitha"

3 Publications

  • Page 1 of 1

Rare case of gemination of mandibular third molar-A case report.

J Family Med Prim Care 2020 May 31;9(5):2577-2579. Epub 2020 May 31.

Department of Periodontics, Sri Sai college of dental surgery, Vikarabad, Telangana, India.

Fusion and germination are the anomalies that occur due to some developmental eccentricity during the time of morpho-differentiation of the tooth bud and have a close resemblance to each other. The gemination is an attempt of the division of a single tooth into two and, hence, appears as an enlarged single tooth while the tooth count is normal when the affected tooth is counted as one. Its exact pathogenesis is ambiguous. This anomaly has been observed mostly in deciduous dentition as compared to that in permanent dentition. Gemination is rarely associated with the third molar and, hence, the terminology is arguable when this condition is seen in relation to the third molar. In the present article, a case of germination of mandibular third molar has been reported.
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May 2020

Role of Nanotechnology in Dentistry: Systematic Review.

J Int Soc Prev Community Dent 2019 Nov-Dec;9(6):535-541. Epub 2019 Nov 4.

Department of Restorative Dental Sciences, College of Dentistry, King Khalid University, Abha, Saudi Arabia.

Aim: This systematic review aimed to provide an overview of role of nanotechnology in dentistry and to evaluate its applicability in prevention and treatment of oral diseases.

Materials And Methods: A systematic literature search was conducted in 2 electronic databases - PMC and Cochrane. The search was restricted to the articles published during the last 5 years. First-level screening was done to select articles for the review on the basis of title and abstract. Then, full texts of selected articles were studied, and relevant articles were selected to be included in this review. Articles selected were critically appraised to evaluate their quality.

Results: Literature search revealed 837 articles in PMC, 15 in Clinical trial register of US National library, and 43 in Cochrane. Additional 6 articles were identified by hand search. Eleven clinical trials were included in this review.

Conclusion: Advancement in nanotechnology has greatly influenced dental disease prevention and therapy significantly.
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November 2019

DNA Laddering to Evaluate Cytogenetic Damage in Patients with Periodontitis.

J Int Soc Prev Community Dent 2019 Sep-Oct;9(5):486-491. Epub 2019 Sep 30.

Department of Oral and Maxillofacial Surgery, Sri Sai College of Dental Surgery, Vikarabad, Telangana, India.

Background: Inflammatory conditions show cytogenetic damage in peripheral blood leukocytes and this can be assessed using various tests. Cytogenetic damage as observed in the peripheral blood cells, is a marker of periodontal disease. DNA laddering is a sensitive assay which evaluates the cytogenetic damage. DNA laddering is a feature that can be observed when DNA fragments, resulting from apoptotic DNA fragmentation, are visualised after separation by gel electrophoresis which results in a characteristic "ladder" pattern.

Aim: The aim of the present study is to investigate the cytogenetic damage in different forms of periodontitis in comparison with healthy controls.

Materials And Methods: In this cross-sectional study, 15 systemically healthy subjects with moderate to severe chronic periodontitis (CGP), 15 systemically healthy subjects with generalised aggressive periodontitis(GAP) and 15 systemically healthy control subjects were recruited. Blood samples of the patients were drawn and evaluated for the cytogenetic damage by DNA laddering.

Results: Apoptotic DNA fragmentation was observed as a "ladder" pattern at 180-200 BP intervals in both CGP and GAP groups indicating the DNA damage, in contrast with the healthy group where the ladder pattern was not observed suggesting of the healthy DNA.

Conclusion: The results indicated that there are cytogenetic damages in both the chronic and aggressive periodontitis groups incontrast to the healthy controls.
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September 2019