Publications by authors named "Ayse Nur Aksoy"

17 Publications

  • Page 1 of 1

The effect of copper intrauterine device use duration on uterine and ovarian blood flow parameters: A prospective cross-sectional study.

J Clin Ultrasound 2021 Feb 2;49(2):124-128. Epub 2020 Dec 2.

Department of Radiology, Faculty of Medicine, Ataturk University, Erzurum, Turkey.

Purpose: This prospective cross-sectional study aimed to compare uterine and ovarian arterial Doppler signals in regularly menstruating patients who had been using copper intrauterine devices (IUD) for different durations.

Methods: Four groups of participants were formed (n = 30 for each) depending on the duration of copper IUD use: less than 1 year (group 1), 1 to 3 years (group 2), and over 3 years (group 3). Women without IUDs formed the control group. All participants were called in on the fifth-eighth days of their menstrual cycle for Doppler blood flow assessment. The pulsatility index (PI) and resistance index (RI) values were recorded in uterine and ovarian arteries.

Results: The groups 2 and 3 had significantly higher uterine artery PI and RI values than groups 1 and 4. Furthermore, group 2 had uterine and ovarian artery PI and RI values similar to those of group 3. There was a positive relationship between uterine and ovarian arteries' PI and RI values with the duration of IUD use.

Conclusions: The presence of an IUD for over a year seems to cause changes in the uterine artery PI and RI values assessed by Doppler ultrasonography.
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http://dx.doi.org/10.1002/jcu.22953DOI Listing
February 2021

The Effect of Anaesthetic Techniques on Maternal and Cord Blood Brain-Derived Neurotrophic Factor Levels.

Turk J Anaesthesiol Reanim 2018 Apr 1;46(2):139-146. Epub 2018 Mar 1.

Department of Anesthesiology and Reanimation, Atatürk University School of Medicine, Erzurum, Turkey.

Objective: Brain-derived neurotrophic factor (BDNF), a member of neurotrophins, plays a critical role in neuronal tissue. In this study, the effects of spinal or general anaesthesia on cord and maternal peripheral blood BDNF and malondialdehyde (MDA) levels were investigated in patients undergoing elective caesarean section.

Methods: Eighty patients with term pregnancy were included. General anaesthesia was induced with intravenous (IV) propofol 2 mg kg in the general anaesthesia group (n=36). In the spinal anaesthesia group (n=35), hyperbaric bupivacaine 0.5%, 9 mg (1.8 mL) was injected intrathecally. Maternal blood samples were taken immediately after positioning the patient on the operating table (T1), before clamping the umbilical cord (T2) and 24 hours after the first sample was obtained (T3). Cord blood samples were drawn from the umbilical artery (T4).

Results: Maternal BDNF levels (pg mL) measured at T2 time point were higher in the general anaesthesia group compared to the spinal anaesthesia group (p<0.001). Cord blood BDNF levels were higher in the general anaesthesia group compared to the spinal anaesthesia group (p<0.001). In both groups, cord blood BDNF levels were significantly lower compared to the maternal blood samples collected at any time point (p<0.001, for all). There was a negative association between both maternal and cord blood BDNF levels with maternal MDA and cord blood MDA levels, respectively (r=-0.379, p<0.001; r=-0.375, p=0.001, respectively).

Conclusion: The anaesthetic technique may have an influence on maternal peripheral and cord blood BDNF levels.
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http://dx.doi.org/10.5152/TJAR.2018.90187DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5937460PMC
April 2018

Serum heme oxygenase-1 levels in patients with primary dysmenorrhea.

Arch Gynecol Obstet 2017 Apr 25;295(4):929-934. Epub 2017 Feb 25.

Department of Obsterics and Gynecology, Nenehatun Hospital, Dr Refik Saydam Street, Palandöken, 25070, Erzurum, Turkey.

Purpose: Primary dysmenorrhea effects the life-quality of women negatively. The aim of this study was to evaluate heme oxygenase-1 (HO1) activity together with malondialdehyde (MDA) and nitric oxide (NO) levels in patients with primary dysmenorrhea.

Methods: A total of 28 nulliparous women with the diagnosis of primary dysmenorrhea and 26 healthy controls were included in this study. On the first day of menstruation, all patients underwent ultrasound examination to exclude pelvic pathology and the visual analogue scale was applied to patients. Patient's visual analogue scale (VAS) scores, age, body mass index (BMI), menstrual cycle length (day), length of bleeding (day) were recorded. In the same day, fasting blood samples were taken from each patient for biochemical analysis.

Results: Serum MDA, NO and HO1 levels were found to be higher in women with primary dysmenorrhea compared to healthy controls (p = 0.012, p = 0.009, p < 0.001, respectively). There were no correlation among serum levels of HO1, NO and MDA, age, BMI, cycle length, pain score and menses duration in both groups. In Pearson's correlation analysis, positive correlation was found between HO1 levels with the NO levels (r = 0.316, p < 0.05) and VAS scores (r = 0.520, p < 0.01). Also, positive correlation was found between MDA levels and VAS scores (r = 0.327, p < 0.05).

Conclusions: Serum HO1, NO and MDA levels increase in patients with primary dysmenorrhea. Antioxidant support might be helpful to reduce pain severity in primary dysmenorrhea.
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http://dx.doi.org/10.1007/s00404-017-4312-1DOI Listing
April 2017

Effects of altitude changes on Doppler flow parameters for uterine, umbilical, and mid-cerebral arteries in term pregnancy: A pilot study.

J Turk Ger Gynecol Assoc 2015 2;16(4):237-40. Epub 2015 Nov 2.

Department of Obsterics and Gynaecology, Nenehatun Maternity Hospital, Erzurum, Turkey.

Objective: We hypothesized that maternal and fetal circulations may be affected by moderately high altitudes. Therefore, we compared the differences in maternal and fetal Doppler flow parameters in women with term pregnancy living at a moderately high altitude (1890 m in Erzurum) with those of women living at the sea level (31 m in İstanbul).

Material And Methods: Eighty women (n=40, for each group) with full-term and singleton pregnancies underwent Doppler waveform analysis, and the pulsatility and resistance index values for the uterine, umbilical, and mid-cerebral arteries were recorded. Also, sex, birth, and placental weights during delivery were obtained from the medical records.

Results: Similar mean placental weight values were found at the sea level compared with the moderately high altitude (p>0.05). The mean birth weight values were found to be lower at the moderately high altitude than those at the sea level (p<0.05). The pulsatility and resistance index values for the umbilical and mid-cerebral arteries were found to be similar between the groups (p>0.05). However, the pulsatility and resistance index values for both the right and left uterine arteries were higher at the sea level than those at moderately high altitude (p<0.05, for all).

Conclusion: Moderately high altitude does not affect fetal vascular Doppler parameters. However, it appears to increase the uterine artery blood flow bilaterally, and these alterations in the bilateral uterine artery blood flow may be associated with a physiological adaptation to high altitude.
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http://dx.doi.org/10.5152/jtgga.2015.15134DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4664216PMC
December 2015

Effect of colchicine on polycystic ovary syndrome: an experimental study.

Arch Gynecol Obstet 2016 Mar 2;293(3):675-80. Epub 2015 Nov 2.

Department of Obstetric and Gynecology, Nenehatun Woman Hospital, Erzurum, Turkey.

Purpose: To investigate whether there is any therapeutic effect of colchicine on a rat model of polycystic ovary syndrome (PCOS).

Methods: Twenty-two Wistar-Albino rats were randomly assigned into four with 8 rats in each group: control group; PCOS only group; PCOS-metformin group and PCOS-colchicine group. PCOS was induced by gavage with letrozole once daily at the concentration of 1 mg/kg orally with 21 consecutive days. After PCOS model assessment, PCOS-metformin group was received metformin orally with 500 mg/kg and PCOS-colchicine group was received colchicine orally with 1 mg/kg for the 35 day. Histopathology of ovaries, circulating estrone (E1), estradiol (E2), total testosterone, androstenedione and c-reactive protein (CRP) levels were evaluated.

Results: cystic and atretic follicle number was significantly decreased, but CRP and hormone parameters were not significantly changed with colchicine treatment.

Conclusion: Colchicine has provided histopathological improvement compared with metformin in PCOS rat model.
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http://dx.doi.org/10.1007/s00404-015-3933-5DOI Listing
March 2016

Association of Glomerular Filtration Rate with Inflammation in Polycystic Ovary Syndrome.

Int J Fertil Steril 2015 Jul-Sep;9(2):176-82. Epub 2015 Jul 27.

Department of Internal Medicine, Erzurum Bölge Training and Research Hospital, Erzurum, Turkey.

Background: We aimed to estimate the glomerular filtration rate (GFR) in women with polycystic ovary syndrome (PCOS) and to determine the relationship between GFR with C-reactive protein (CRP) and uric acid.

Materials And Methods: In this cross-sectional study, one-hundred and forty PCOS women and 60 healthy subjects were evaluated. The study was carried out at Endocrinol- ogy Outpatient Clinic, Erzurum Training and Research Hospital, Erzurum, Turkey, from December 2010 to January 2011. GFRs were estimated by Modification of Diet in Renal Disease (MDRD) formula. CRP, urinary albumin excretion (UAE) and uric acid levels were also measured.

Results: GFRs were significantly higher in PCOS group than control (135.24 ± 25.62 vs. 114.92 ± 24.07 ml/min per 1.73 m(2)). CRP levels were significantly higher in PCOS patients (4.4 ± 3.4 vs. 2.12 ± 1.5 mg/l). The PCOS group had significantly higher serum uric acid levels (4.36 ± 1.3 mg/dl vs. 3.2 ± 0.73 mg/dl). There was also significantly higher proteinuria level in PCOS patients.

Conclusion: Even though PCOS patients had higher GFR, serum uric acid and UAE val- ues than control patients, the renal function was within normal limits. Increased GFR in PCOS women positively correlates with elevated serum CRP and uric acid.
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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4518485PMC
http://dx.doi.org/10.22074/ijfs.2015.4238DOI Listing
August 2015

The Effect of Controlled Reperfusion in the Prevention of Infertility Caused by Ischemia Induced in the Contralateral Ovary in Rats with Unilateral Ovariectomy.

Gynecol Obstet Invest 2015 20;80(3):199-205. Epub 2015 Mar 20.

Department of Obsterics and Gynaecology, Nenehatun Hospital, Erzurum, Turkey.

Background/aims: To investigate the effectiveness of controlled reperfusion (CR) on ovarian tissue malondialdehyde, total glutathione and 8-hydroxyguanine levels and infertility rates in a rat model of induced ischemia-reperfusion (I/R) injury with unilateral oophorectomy.

Methods: A total of 135 adult female albino Wistar rats were divided into 9 groups (n = 15 for each group): unilateral ovariectomy + ovarian I/R (OIR), unilateral ovariectomy alone (OEG), a sham operation group (SG), and unilateral ovariectomy + CR performed at different intervals (the clips were released 10 times for 10, 8, 6, 4, 2 or 1 s and closed again 10 times for 10, 8, 6, 4, 2 or 1 s; OCR-1-6, respectively). Five rats from each group were sacrificed, and their ovaries were removed.

Results: Higher ovarian tissue malondialdehyde and 8-hydroxyguanine levels and lower ovarian tissue total glutathione levels were found in the OIR group compared with the SG, OEG and OCR-4-6 groups. The number of rats giving birth during the study period was found to be similar among the SG (n = 8), OEG (n = 8) and OCR-6 (n = 7) groups.

Conclusion: These results suggest that sterility and ovarian oxidative stress caused by I/R injury decreases in parallel to the shortening of CR duration.
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http://dx.doi.org/10.1159/000377701DOI Listing
August 2016

The role of antioxidant activity in the prevention and treatment of infertility caused by Cisplatin in rats.

Gynecol Obstet Invest 2015 27;79(2):119-25. Epub 2015 Jan 27.

Department of Obsterics and Gynecology, Nenehatun Hospital, Erzurum, Turkey.

Background/aims: To investigate the importance of antioxidant activity in infertility caused by cisplatin in rats.

Methods: Rats in cisplatin control (CG), Vitamin E + cisplatin (ECG), Vitamin C + cisplatin (CCG), Hippophae rhamnoides extract (HRE) + cisplatin (HRECG), and thiamine pyrophosphate (TPP) + cisplatin (TPPCG) groups were injected intraperitoneally (ip) with (100 mg/kg) Vitamin E, Vitamin C, HRE, and TPP, respectively. One hour later, ip cisplatin was administered (5 mg/kg), and then antioxidant medications were continued for 10 days. Cisplatin + Vitamin E (CEG-1), cisplatin + Vitamin C (CCG-1), cisplatin + HRE (CHREG-1), and cisplatin + TPP (TPPCG-1) rats received cisplatin (5 mg/kg, ip) and were kept for 10 days. At the end of that period, rats received antioxidant medications for 10 days. (n = 12, for each group). Six rats from each group were sacrificed. Ovaries were removed to measure malondialdehyde, total glutathione, glutathione S-transferase, and glutathione reductase levels. The remaining rats were kept in a suitable laboratory environment.

Results: Cisplatin-induced oxidative stress was best prevented by HRE, Vitamin E, Vitamin C, and TPP, in that order. However, infertility caused by cisplatin was only prevented and treated by TPP.

Conclusion: Oxidative stress is not a major component in the pathogenesis of cisplatin-associated infertility.
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http://dx.doi.org/10.1159/000367657DOI Listing
December 2015

The effect of progesterone on systemic inflammation and oxidative stress in the rat model of sepsis.

Indian J Pharmacol 2014 Nov-Dec;46(6):622-6

Department of Biochemistry, Faculty of Medicine, Atatürk University, Erzurum, Turkey.

Objectives: To explore the protective effect of progesterone on inflammation and oxidative stress in a rat model of sepsis created by cecal ligation and puncture (CLP).

Materials And Methods: Rats were randomly divided into 4 groups: Overiectomy group (OVX), sham operated (control), sepsis (CLP) group and progesterone-treated CLP group (CLP+ progesterone). The rats in CLP+ progesterone group received intraperitoneal progesterone (2 mg/kg). Cardiac blood samples were obtained for the measurement levels of interleukin-6 (IL-6) and tumor necrosis factor-α (TNF-α). Tissue samples, including liver, kidney and uterus of rats were prepared to determine activities of myeloperoxidase (MPO), glutathione peroxidase (GPx) and levels of malondialdehyde (MDA).

Results: Increased serum IL-6 and TNF-α levels were found in the CLP group in comparison with the control group (P = 0.01, P = 0.02; respectively). In CLP+ progesterone group, mean MDA concentration of kidney tissue was significantly lower than in CLP group (P = 0.003). Liver MDA concentration of the CLP+ progesterone group was not significantly different from that of the control group. While there were no significant differences among groups regarding liver MPO; in the CLP group, MPO activity in kidney (P = 0.02) and uterine tissues (P = 0.03) were found to be significantly higher compared to the control group. In CLP+ progesterone group, mean MPO activities of all tissues were not different than those of control group. The uterine tissue GPx activity in the CLP+ progesterone group was not statistically significantly different from control group.

Conclusions: We suggest that progesterone ameliorates sepsis syndrome by reduction of the inflammatory cytokines IL-6 and TNF-α, and by restoration of antioxidant enzyme activities in some tissues.
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http://dx.doi.org/10.4103/0253-7613.144922DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4264078PMC
August 2015

The Relationship between Fear of Childbirth and Women's Knowledge about Painless Childbirth.

Obstet Gynecol Int 2014 12;2014:274303. Epub 2014 Nov 12.

Department of Anaesthesiology and Reanimation, Faculty of Medicine, Ataturk University, 25240 Erzurum, Turkey.

This study investigated the association between fear of childbirth (FOC) and women's knowledge about painless childbirth methods. The study was performed on 900 multiparous women within the last month of pregnancy. Data was obtained through a questionnaire including the Wijma Delivery Expectancy/Experience Questionnaire (W-DEQ) Turkish form A. FOC was defined as W-DEQ sum score ≥85. Women were questioned about their knowledge about painless childbirth and the most important source of this knowledge. Group 1 consists of participants with knowledge about painless childbirth. Group 2 consists of participants without knowledge about painless childbirth. Five hundred and twenty-four women (58.2%) had knowledge while 376 women (41.7%) had no knowledge about painless childbirth. Mean W-DEQ scores in group 1 (68.46 ± 12.53) were found to be lower than group 2 (71.35 ± 12.28) (P = 0.001). FOC was associated with increased maternal request for elective caesarean section (OR 4.22, 95% CI 2.91-6.11). Better informed pregnant women about painless childbirth methods may reduce the number of women with FOC and the rate of preferred elective caesarean section.
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http://dx.doi.org/10.1155/2014/274303DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4244920PMC
December 2014

Sildenafil reduces ischemia-reperfusion injury in rat ovary: biochemical and histopathological evaluation.

Gynecol Obstet Invest 2014 18;78(3):162-7. Epub 2014 Jun 18.

Biochemistry Laboratory, Goverment Hospital of Oltu, Erzurum, Turkey.

Background/aims: To evaluate the effects of sildenafil on antioxidant enzyme activities, lipid peroxidation and histopathological changes in ovarian tissue after ischemia-reperfusion (I/R) injury in a rat model.

Methods: A total of 18 adult female Wistar albino rats weighing 200-250 g were studied as follows: (1) control group: sham operation, (2) I/R group: 3 h of reperfusion after 3 h of ischemia and (3) I/R + sildenafil group: 3 h of reperfusion after 3 h of ischemia; half an hour before reperfusion, sildenafil (1.4 mg·kg(-1)) was given by oral gavage. At the end of the reperfusion periods, the ovarian tissues were removed for histopathological examination and to determine malondialdehyde (MDA) levels and glutathione peroxidase, myeloperoxidase (MPO) and superoxide dismutase (SOD) activities.

Results: The I/R group had higher ovarian tissue MDA levels than the control group and the IR + sildenafil group (p = 0.016 and p = 0.044, respectively). MPO activity was lower in the IR + sildenafil group compared with the I/R group (p = 0.022). SOD activity was lower in the I/R group compared with the control group and the I/R + sildenafil group (p = 0.030 and p = 0.015, respectively). The I/R + sildenafil group had improved histological appearance which was not different to the control group (p > 0.05).

Conclusion: The biochemical and histopathological results of this experimental study demonstrated that I/R injury in the ovary is ameliorated by sildenafil treatment.
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http://dx.doi.org/10.1159/000363747DOI Listing
June 2015

Anaesthesia Techniques for Caesarean Operations: Retrospective Analysis of Last Decade.

Turk J Anaesthesiol Reanim 2014 Jun 11;42(3):128-32. Epub 2014 Mar 11.

Department of Anaesthesiology and Reanimation, Atatürk University Faculty of Medicine, Erzurum, Turkey.

Objective: The technique of anaesthesia in caesarean sections is selected according to the patient's clinical presentation, experience of the anaesthesist and the patient's wishes. The purpose of this study was to evaluate the anaesthesia methods employed in our clinic in the last decade (2003-2012).

Methods: Records of caesarean operations performed between 2003-2012 in the Anaesthesia department of Atatürk University Medical Faculty and stored in the hospital computer system were examined. The annual distribution of methods of anaesthesia in operations was analysed.

Results: During 2003-2012, 9049 caesarean operations were performed in our clinic. General anaesthesia was used in 45% of operations and regional anaesthesia in 54%. Whereas the rate of regional anaesthesia in 2003 was 34%, this increased to 69% in 2012. The most commonly used method of regional anaesthesia was spinal anaesthesia (34%) in 2003, and spinal anaesthesia (41%) and combined spinal-epidural anaesthesia (27%) in 2012.

Conclusion: The most commonly used anaesthesia technique for caesarean operations in our clinic between 2003-2012 was spinal anaesthesia. The most widely used regional anaesthetic method in our clinic was spinal anaesthesia. A significant increase in the use of the combined spinal-epidural anaesthetic technique occurred in the last two years of the study period.
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http://dx.doi.org/10.5152/TJAR.2014.80774DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4894220PMC
June 2014

Prevalence of depressive disorders and related factors in women in the first trimester of their pregnancies in Erzurum, Turkey.

Int J Soc Psychiatry 2014 Dec 26;60(8):809-17. Epub 2014 Feb 26.

Department of Psychiatry, Erzurum Bolge Training and Research Hospital, Erzurum, Turkey.

Introduction: Depression is the most frequently seen mental disease in the pregnancy period. The first trimester of pregnancy is important in terms of its effects on both the fetus and on the mother. This study has researched the prevalence of depression in women in the first trimester of their pregnancies in Erzurum, which is a large province in the Eastern region of Turkey.

Method: The study participants were 463 pregnant women who were in the first trimester of their pregnancy. Screening was primarily carried out using the Edinburgh Postnatal Depression Scale (EPDS), and Structured Clinical Interview for Diagnostic and Statistical Manual of Mental Disorders-Fourth Edition (DSM-IV)-Clinical Version (SCID-I) was applied to those participants with a score of 12 points and higher. To assess the risk factors, a sociodemographic data form was completed by the authors.

Results: The total depressive disorder rate was 16.8% in women in the first trimester of their pregnancies (12.3% major depressive disorder, 1.5% double depression, 2.6% minor depressive disorder and 0.4% dysthymia). A history of mental disease, mental disease suffered during a previous pregnancy, exposure to violence in the present pregnancy, an unplanned pregnancy and spouse's unemployment were predictors for depressive disorders.

Conclusion: It is important to identify the risk groups for the early recognition of depression in pregnancy. Developing depression screening programs can be useful for early diagnosis and therapy.
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http://dx.doi.org/10.1177/0020764014524738DOI Listing
December 2014

Evaluation of the efficacy of Fructus agni casti in women with severe primary dysmenorrhea: a prospective comparative Doppler study.

J Obstet Gynaecol Res 2014 Mar 18;40(3):779-84. Epub 2013 Nov 18.

Department of Obstetrics and Gynecology, Nenehatun Hospital, Erzurum.

Aim: The aim of this case-control study was to compare the efficacy of ethinyl estradiol/drospirenone and Fructus agni casti in women with severe primary dysmenorrhea measuring uterine artery blood flow via Doppler ultrasonography.

Methods: A total of 60 women with severe primary dysmenorrhea and 30 healthy women (control) were included in this study. Thirty patients were treated with ethinyl estradiol 0.03 mg/drospirenone (group 1) and another 30 were treated with Fructus agni casti (group 2) during three menstrual cycles. Before and at the end of third month of therapy visual analog scale (VAS) scores, pulsatility index (PI), resistance index (RI) of uterine artery were recorded before and after receiving therapy on the first day of the menstrual cycle.

Results: Mean PI and RI values in patients with severe primary dysmenorrhea were significantly higher than in the control groups on the first day of the menstrual cycle (P < 0.0001). Mean PI and RI values were significantly lower after the treatment in both groups compared to before values (P < 0.001 for both). After using the drugs for three menstrual cycles, VAS scores were significantly dropped in both groups compared to before treatment values (P < 0.0001 for both); however, there were no significant differences in terms of Doppler findings between group 1 and 2.

Conclusion: The effectiveness of Fructus agni casti was similar to that of ethinyl estradiol/drospirenone in patients with primary dysmenorrhea.
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http://dx.doi.org/10.1111/jog.12221DOI Listing
March 2014

Serum lipid profile, oxidative status, and paraoxonase 1 activity in hyperemesis gravidarum.

J Clin Lab Anal 2009 ;23(2):105-9

Department of Biochemistry, School of Medicine, Ataturk University, Erzurum, Turkey.

The aim of this study was to investigate lipid profile, paraoxonase 1 (PON1) activity, and oxidative stress status in the serum of hyperemesis gravidarum (HG) patients. Thirty-six HG cases and 36 normal pregnants were included in the study. Serum total cholesterol (TC), triglyceride (TG), high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C), apoproteins A1 (apo A1) and B (apo B), malondialdehyde (MDA), and total antioxidant activity (TAO) values and PON1 and arylesterase activities were determined. Although serum TC, TG, LDL-C, and apo B levels were not different among; the groups (P>0.05), HDL-C (P=0.01) and apo A1 (P=0.007) levels were lower in HG patients than in normal pregnants. HG group had significantly lower serum PON1 (P=0.03) and arylesterase activities (P=0.03) compared with the control group. Additionally, mean TAO values were lower (P=0.01) and MDA levels were higher (P=0.02) in HG group than in the healthy pregnants. A significant negative correlation between PON1 and MDA was found in HG group (r=-0.33, P<0.05). The findings of this study have revealed that HG may be one of the conditions in which oxidant and antioxidant balance is impaired.
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http://dx.doi.org/10.1002/jcla.20298DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6649153PMC
April 2009

Hyperemesis Incidence in Planned versus Unplanned Pregnancy.

Authors:
Ayse Nur Aksoy

Eurasian J Med 2008 Aug;40(2):72-4

Department of Obstetrics and Gynecology, Nenehatun Hospital, Erzurum, Turkey.

Objective: We evaluated the incidence of hyperemesis between planned and unplanned pregnancy.

Materials And Methods: A prospective study was conducted among 100 women with planned pregnancies and 100 women with unplanned pregnancies. Participants completed a questionnaire to determine the presence of vomiting. If pregnant women had severe vomiting (>3 times per day), urinary investigation was performed; at least one positive ketonuria was considered as hyperemesis.

Results: There was a significant difference between planned and unplanned pregnancy in terms of the incidence of hyperemesis (p=0.0001). Women with unplanned pregnancies had a more than 18-fold increased risk of hyperemesis (OR=18.88; %95 CI, 8.84-40.31) compared to women with planned pregnancies.

Conclusion: Healthy women may be able to improve their management of hyperemesis during pregnancy if they plan their pregnancies.
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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4261684PMC
August 2008

Paraoxonase and arylesterase activities in patients with preeclampsia.

Eurasian J Med 2008 Apr;40(1):10-3

Atatürk University, Faculty of Medicine, Department of Biochemistry, Erzurum, Turkey.

Objective: Paraoxonase is a high density lipoprotein-associated anti-oxidant enzyme. The aim of this study was to investigate the serum paraoxonase and arylesterase activities and associations between these enzymes and lipid hydroperoxide (LOOH) in preeclamptic patients.

Materials And Methods: The study included 47 preeclamptic (25 severe and 22 mild preeclampsia cases) and 20 normotensive healthy pregnant women. Serum paraoxonase and arylesterase activities and LOOH levels were measured.

Results: While serum paraoxonase and arylesterase activities were significantly lower in both severe and mild preeclamptic patients (P<0.05 for both) than those in normal pregnant subjects, LOOH levels were significantly higher in severe (P<0.01) and mild preeclampsia cases (P<0.05) than in normotensive pregnant subjects. When all subjects were evaluated, there was a negative correlation between paraoxonase and LOOH (r=-0.24, P<0.05) and between arylesterase and LOOH (r=-0.31, P<0.01).

Conclusion: Our results show that serum paraoxonase and arylesterase activities decrease in preeclampsia, and this situation may be associated with increased LOOH in these patients.
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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4261318PMC
April 2008