Publications by authors named "Ayoub Saeidi"

24 Publications

  • Page 1 of 1

The effects of exercise training on plasma volume variations: A systematic review.

Int J Sports Med 2021 Oct 12. Epub 2021 Oct 12.

Higher Institute of Sport and Physical Education of Ksar-Saïd, Manouba, Tunisia., Higher Institute of Sport and Physical Education of Ksar-Saïd, Manouba, Tunisia., Tunis, Tunisia.

The aim of this systematic review was to summarize the evidence on the acute and long-term effects of exercise training on PV, in both trained and untrained individuals and to examine associations between changes in %PVV and change in physical/physiological performance. Despite the status of participants and the exercise duration or intensity, all the acute studies reported a significant decrease of PV (effect size: 0.85
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1055/a-1667-6624DOI Listing
October 2021

The Effects of Aerobic-Resistance Training and Broccoli Supplementation on Plasma Dectin-1 and Insulin Resistance in Males with Type 2 Diabetes.

Nutrients 2021 Sep 9;13(9). Epub 2021 Sep 9.

M2S (Laboratoire Mouvement, Sport, Santé)-EA 1274, University of Rennes, F-35000 Rennes, France.

Background: This study aimed to evaluate the effects of a combination of aerobic-resistance training (CARET) and broccoli supplementation on dectin-1 levels and insulin resistance in men with type 2 diabetes mellitus (T2D).

Methods: Forty-four males with T2D were randomly allocated to four groups ( = 11 each group): CARET + broccoli supplement (TS), CARET + placebo (TP), control + broccoli supplement (S), and control + placebo (CP). CARET was performed three days per week for 12 weeks. TS and S groups received 10 g of broccoli supplement per day for 12 weeks. All variables were assessed at baseline and 12 weeks.

Results: Plasma dectin-1 levels were decreased in TS and TP groups compared with the CP group ( < 0.05). Cardiometabolic risk factors showed significant reductions in TP and TS groups compared to S and CP groups ( < 0.05).

Conclusion: The combination of CARET and broccoli supplementation produced the largest improvements in insulin resistance and dectin-1 and other complications of T2D.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.3390/nu13093144DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8471572PMC
September 2021

High-intensity Interval Training Improves Lipocalin-2 and Omentin-1 Levels in Men with Obesity.

Int J Sports Med 2021 Jul 28. Epub 2021 Jul 28.

Univ Rennes, M2S (Laboratoire Mouvement, Sport, Santé) - EA 1274, F-35000 Rennes, France.

We investigated the effects of 12 weeks of high-intensity interval training (HIIT) on selected circulating adipokines and other cardiovascular diseases risks factors in men with obesity. Thirty men with obesity (age: 24.96±3.11 year, BMI: 30.92±1.04 kg/m) were randomly assigned to HIIT and control groups. The HIIT group participated in a 12-week HIIT program (5×2 min interval bout at an intensity of 85-95% HRmax interspersed by 1 min passive recovery, three times per week), while the control group maintained their usual lifestyles. Blood lipids, insulin resistance, and select serum adipokines were assessed before and after 12 weeks of the intervention period. HIIT improved body composition and lipid profiles (p<0.05) and also decreased fasting insulin levels (p=0.001) and HOMA-IR (p=0.002) levels. Furthermore, HIIT increased levels of lipocalin-2 (p=0.002) while decreasing omentin-1 levels (p=0.001) in men with obesity. Changes in lcn2 and omentin-1 concentrations correlated with the changes in risk factors in the HIIT group (p<0.05). The results indicate that 12 weeks of supervised HIIT significantly improves both circulating concentrations of lcn2 and omentin-1, two recently described adipokines, and risk markers of cardiovascular diseases in men with obesity. Further research is necessary to understand the molecular mechanisms involved with these changes.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1055/a-1560-5401DOI Listing
July 2021

Physical activity and adipokine levels in individuals with type 2 diabetes: A literature review and practical applications.

Rev Endocr Metab Disord 2021 Apr 30. Epub 2021 Apr 30.

Department of Physical Education and Sport Sciences, University of Kurdistan, Sanandaj, Iran.

We review the effects of acute and long-term physical activity on adipokine levels in individuals with type 2 diabetes (T2D). Three electronic databases were searched. Studies made in animal models were excluded, while studies based on participants with and without T2D, and also studies with type 1 diabetes were included. Of the 2,450 citations, 63 trials, including randomised control trials, cross-sectional and longitudinal studies, met our inclusion criteria. Seventy and five percent of studies reported the effects of physical activity on tumor necrosis factor-alpha (TNFα), interleukin 6 (IL-6), adiponectin, visfatin, omentin-1, and leptin levels. There are no robust results due to variations in exercise modality, intensity, duration, and also differences in cohort characteristics in the literature. Only four studies described the effects of an acute session of physical activity on adipokine levels. Overall, physical activity improves diabetes status by regulating adipokine levels. However, long-term aerobic + resistance training combined with dietary modifications is likely to be a more effective strategy for improving adipokines profiles in patients with type 2 diabetes.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1007/s11154-021-09657-xDOI Listing
April 2021

Resistance training, gremlin 1 and macrophage migration inhibitory factor in obese men: a randomised trial.

Arch Physiol Biochem 2020 Dec 28:1-9. Epub 2020 Dec 28.

Univ Rennes, M2S (Laboratoire Mouvement, Sport, Santé) - EA 1274, Rennes, France.

Objective: This study aimed to determine how different resistance training protocols affect gremlin 1, macrophage migration inhibitory factor (MIF), cardiometabolic, and anthropometric measures in obese men.

Methods: Forty-four males with obesity (weight: 93.2 ± 2.2 kg, BMI: 32.9 ± 1.2 kg/m, age: 27.5 ± 9.4 years) were randomly assigned to traditional resistance training (TRT,  = 11), circuit resistance training (CRT,  = 11), interval resistance training (IRT,  = 11) or control (C,  = 11) groups. TRT group performed ten exercises at 50% of 1RM with 14 repetitions for three sets and 30 seconds rest interval between exercises and 1.5 min rest between sets, the CRT protocol included three circuits of 10 exercises, at an intensity of 50% of 1-RM, 14 repetitions with a minimum rest (< 15 s) between exercises and 3 min rest between sets, and the IRT group performed two sets of the same exercises with 50% of 1 RM, and 14 repetitions were followed with active rest of 25% of 1RM and 14 repetitions. All resistance training groups performed 60 min per session resistance exercises, 3 days per week, for 12 weeks. Measurements were taken at baseline and after 12 weeks of exercise training.

Results: Resistance training (TRT, CRT, and IRT) significantly decreased plasma levels of gremlin (TRT from 231.0 ± 5.8 to 210.0 ± 11.6 ng/ml, CRT from 226.0 ± 7.6 to 188.0 ± 7.7 ng/ml and, IRT from 227.0 ± 6.3 to 183.0 ± 9.0 ng/ml, effect size (ES): 0.50), MIF (TRT from 251.0 ± 7.4 to 260.0 ± 6.5 ng/ml, CRT from 248.0 ± 10.9 to 214.0 ± 9.0 ng/ml and, IRT from 247.0 ± 8.9 to 196.0 ± 6.9 ng/ml, ES: 0.55) and CRP (TRT from 28.4 ± 1.7 to 23.3 ± 2.1 nmol/l, CRT from 28.5 ± 2.2 to 21.1 ± 1.8 nmol/l, IRT from 28.1 ± 1.3 to 20.8 ± 1.3 nmol/l, ES: 0.49) compared to the control group ( < .05), but these reduction were greater in the CRT and IRT groups compared to the TRT group ( < .05).

Conclusion: The CRT and IRT protocols had more beneficial improvement in gremlin 1, MIF, body composition, and cardiometabolic risk factors compared to the beneficial changes produced by TRT protocol.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1080/13813455.2020.1856142DOI Listing
December 2020

L-Arginine Improves Endurance to High-Intensity Interval Exercises in Overweight Men.

Int J Sport Nutr Exerc Metab 2020 Dec 1;31(1):46-54. Epub 2020 Dec 1.

Université Rennes 2.

The effects of acute consumption of L-Arginine (L-Arg) in healthy young individuals are not clearly defined, and no studies on the effects of L-Arg in individuals with abnormal body mass index undertaking strenuous exercise exist. Thus, we examined whether supplementation with L-Arg diminishes cardiopulmonary exercise testing responses, such as ventilation (VE), VE/VCO2, oxygen uptake (VO2), and heart rate, in response to an acute session of high-intensity interval exercise (HIIE) in overweight men. A double-blind, randomized crossover design was used to study 30 overweight men (age, 26.5 ± 2.2 years; body weight, 88.2 ± 5.3 kilogram; body mass index, 28.0 ± 1.4 kg/m2). Participants first completed a ramped-treadmill exercise protocol to determine VO2max velocity (vVO2max), after which they participated in two sessions of HIIE. Participants were randomly assigned to receive either 6 g of L-Arg or placebo supplements. The HIIE treadmill running protocol consisted of 12 trials, including exercise at 100% of vVO2max for 1 min interspersed with recovery intervals of 40% of vVO2max for 2 min. Measurements of VO2 (ml·kg-1·min-1), VE (L/min), heart rate (beat per min), and VE/VCO2 were obtained. Supplementation with L-Arg significantly decreased all cardiorespiratory responses during HIIE (placebo+HIIE vs. L-Arg+HIIE for each measurement: VE [80.9 ± 4.3 L/min vs. 74.6 ± 3.5 L/min, p < .05, ES = 1.61], VE/VCO2 [26.4 ± 1.3 vs. 24.4 ± 1.0, p < .05, ES = 1.8], VO2 [26.4 ± 0.8 ml·kg-1·min-1 vs. 24.4 ± 0.9 ml·kg-1·min-1, p < .05, ES = 2.2], and heart rate [159.7 ± 6.3 beats/min vs. 155.0 ± 3.7 beats/min, p < .05, d = 0.89]). The authors conclude consuming L-Arg before HIIE can alleviate the excessive physiological strain resulting from HIIE and help to increase exercise tolerance in participants with a higher body mass index who may need to exercise on a regular basis for extended periods to improve their health.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1123/ijsnem.2020-0054DOI Listing
December 2020

Effects of Ramadan Intermittent Fasting on Gut Hormones and Body Composition in Males with Obesity.

Int J Environ Res Public Health 2020 08 3;17(15). Epub 2020 Aug 3.

ISSEP Ksar Said, University of La Manouba, Tunis 2000, Tunisia.

We studied the effects of Ramadan intermittent fasting (RIF) on gut hormones (leptin, glucagon-like peptide-1 (GLP-1), peptide YY (PYY), cholecystokinin (CCK), and ghrelin) in males with obesity. Thirty sedentary males were randomly allocated to either an experimental group (EG, = 15) or a control group (CG, = 15). The EG group completed their Ramadan fasting rituals (30 days), whereas the CG continued with their normal daily habits. Blood samples were collected at four time points: 24 h before the start of Ramadan (T0), on the 15th day of Ramadan (T1), the day after the end of Ramadan (T2) and 21 days after Ramadan (T3). There were significant pre-to-post improvements for leptin ( = 0.01, = 1.52), GLP-1 ( = 0.022, = 0.75), PYY ( = 0.031, = 0.69) and CCK ( = 0.027, = 0.81) in the EG, with no interaction effect for ghrelin ( = 0.74; = 0.008). No significant changes ( > 0.05) occurred in plasma volume variations (ΔPV) after RIF in both EG (-0.03 ± 0.01%) and CG (0.06 ± 0.07%). RIF represents an effective strategy to modify appetite-regulating hormones, leading to improved body composition indices and reduced obesity.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.3390/ijerph17155600DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7432640PMC
August 2020

The effects of physical activity on adipokines in individuals with overweight/obesity across the lifespan: A narrative review.

Obes Rev 2021 01 13;22(1):e13090. Epub 2020 Jul 13.

Movement, Sport and Health Sciences Laboratory (M2S), UFR-STAPS, University of Rennes 2-ENS Rennes, Rennes, France.

This narrative review summarizes current knowledge on the effects of physical activity (PA) on adipokine levels in individuals with overweight and obesity. Approximately 90 investigations including randomized control, cross-sectional and longitudinal studies that reported on the effects of a single session of PA (acute) or long-term PA (chronic) on adipokine levels in individuals with overweight/obesity were reviewed. The findings support the notion that there is consensus on the benefits of chronic exercise training-regardless of the mode (resistance vs. aerobic), intensity and cohort (healthy vs. diabetes)-on adipokine levels (such as tumour necrosis factor-alpha, interleukin-6, adiponectin, visfatin, omentin-1 and leptin). However, several confounding factors (frequency, intensity, time and type of exercise) can alter the magnitude of the effects of an acute exercise session. Available evidence suggests that PA, as a part of routine lifestyle behaviour, improves obesity complications by modulating adipokine levels. However, additional research is needed to help identify the most effective interventions to elicit the most beneficial changes in adipokine levels in individuals with overweight/obesity.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1111/obr.13090DOI Listing
January 2021

Resistance Exercise in a Hot Environment Alters Serum Markers in Untrained Males.

Front Physiol 2020 23;11:597. Epub 2020 Jun 23.

Université de Rennes, M2S (Laboratoire Mouvement, Sport, Santé) - EA 1274, Rennes, France.

We examined the effects of moderate resistance exercise (RE) on serum cortisol, testosterone, extracellular heat shock protein (HSP70), and interleukin (IL)-6 and IL-15 concentrations in untrained males in a hot environment. Ten untrained young males (26 ± 3 years; 75.8 ± 6 kg; 177.4 ± 5.3 cm) performed two series of full body RE [3 sets of 8 to 10 repetitions, 30-60 s recovery between series with 70% of one maximal repetition (1-RM), with a rest period of 1 to 3 min between exercises] carried out in a random order in both heated (∼35°C) and thermoneutral (22°C) conditions. Serum concentrations of testosterone, cortisol, HSP70, and IL-6 and IL-15 were measured before, at the end, and 1 h after RE sessions. Participants in both groups consumed 4 ml of water/kg body mass every 15 min. There were time-related changes in testosterone, HSP70, and IL-6 ( < 0.001), and cortisol and IL-15 ( < 0.05). Levels of cortisol, HSP70, and IL-6 increased immediately for RE at 35°C, and testosterone and IL-15 levels were decreased. Changes in serum testosterone, HSP70, cortisol, and IL-15 and IL-6 levels were reversed after 1 h. A significant time × condition interaction was observed for IL-15 and HSP70 ( < 0.001), cortisol and IL-6 ( < 0.05), but not for testosterone ( > 0.05). RE in a heated environment may not be appropriate for achieving muscle adaptations due to acute changes of hormonal and inflammatory markers.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.3389/fphys.2020.00597DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7324790PMC
June 2020

Effects of physical training on anthropometrics, physical and physiological capacities in individuals with obesity: A systematic review.

Obes Rev 2020 09 8;21(9):e13039. Epub 2020 May 8.

Department of Sport Sciences, College of Arts and Sciences, Qatar University, Doha, Qatar.

Increasing the amount of physical activity is an important strategy for weight loss. This systematic review summarizes recent findings on the effects of physical training on anthropometric characteristics, physical performances and physiological capacities in individuals with overweight and obesity. A systematic literature search strategy was conducted from inception until June 2019 using four electronic databases that identified 2,708 records. After screening for titles, abstracts and full texts, 116 studies were included in our final analysis. Both aerobic (e.g., endurance training) and anaerobic training (e.g., high-intensity training, resistance training) improved body composition and physical fitness indicators in adults, adolescents and children with obesity (effect size: 0.08 < d < 2.67, trivial to very large). This systematic review suggests that both low- and high-intensity training significantly reduced body weight and fat mass while increasing fat-free mass in individuals with obesity (effect size: 0.04
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1111/obr.13039DOI Listing
September 2020

Heart Rate Variability is Correlated with Perceived Physical Fitness in Elite Soccer Players.

J Hum Kinet 2020 Mar 31;72:141-150. Epub 2020 Mar 31.

CNRS 6214 Inserm 1083 Faculté de Médecine 49045 Angers, France.

Heart Rate Variability (HRV) has been typically used to monitor athletes' physical fitness readiness. The supine position maximizes parasympathetic tone, which is important for monitoring in continuous aerobic sports, however, this is not the case of team sports that rely on anaerobic intermittent bouts, thus increasing sympathetic activation and vagal withdrawal. We hypothesized that HRV during sympathetic activation and vagal withdrawal would be a useful marker to evaluate perceived physical fitness in team sports. HRV was measured in both supine and standing positions during the mornings of 4 match days in 14 professional players. The supine Root Mean Square of the Successive Differences (RMSSD), as well as spectral analysis indices were recorded. Perceived physical fitness was assessed after each match by means of a visual analogue scale (VAS). Supine RMSSD was moderately correlated with perceived physical fitness (rho = 0.416), however, larger correlations were observed for supine and standing spectral indices (rho > 0.5). Correlation between RMSSD and Total Power was very large, thus questioning the usual interpretation of RMSSD (rho > 0.7). Standing Spectral HRV analyses may be a useful method for evaluating perceived physical fitness in the context of team sports. RMSSD may reflect the overall variability of HR and not only the parasympathetic influence, as observed in the current study.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.2478/hukin-2019-0103DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7126242PMC
March 2020

Exercise Training and Fasting: Current Insights.

Open Access J Sports Med 2020 21;11:1-28. Epub 2020 Jan 21.

Higher Institute of Sport and Physical Education, Ksar-Said, University of Manouba, Manouba, Tunisia.

Fasting is defined as the abstinence from consuming food and/or beverages for different periods of time. Both traditional and modern healthcare systems recommend fasting as a therapeutic intervention for the management of several chronic, non-infectious diseases. Exercising during a fasting state increases lipolysis in adipose tissue while also stimulating peripheral fat oxidation, resulting in increased fat utilization and weight loss. A key focus of this review is to assess whether endurance training performed while fasting induces specific training adaptations, where increased fat oxidation improves long-term endurance levels. Fasting decreases body weight, lean body and fat content in both trained and untrained individuals. Several studies indicate a broader impact of fasting on metabolism, with effects on protein and glucose metabolism in sedentary and untrained subjects. However, there are conflicting data regarding the effects of fasting on glucose metabolism in highly trained athletes. The effects of fasting on physical performance indicators also remain unclear, with some reporting a decreased performance, while others found no significant effects. Differences in experimental design, severity of calorie restriction, duration, and participant characteristics could, at least in part, explain such discordant findings. Our review of the literature suggests that there is little evidence to support the notion of endurance training and fasting-mediated increases in fat oxidation, and we recommend that endurance athletes should avoid high intensity training while fasting.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.2147/OAJSM.S224919DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6983467PMC
January 2020

Plasma retinol-binding protein-4 and tumor necrosis factor-α are reduced in postmenopausal women after combination of different intensities of circuit resistance training and Zataria supplementation.

Sport Sci Health 2019 Dec 15;15(3):551-558. Epub 2019 Mar 15.

Univ Rennes, M2S (Laboratoire Mouvement, Sport, Santé)-EA 1274, 35000 Rennes, France.

Purpose: is a plant with anti-inflammatory properties, which has been used for the treatment of many diseases. This study investigated the effect of different intensities of circuit resistance training and supplementation on plasma retinol-binding protein-4 (RBP-4) and tumor necrosis factor-α (TNF-α) in postmenopausal women.

Methods: Seventy-two postmenopausal women were divided on randomized order into six groups: Control (McGinley and Bishop in J Appl Physiol 121(6):1290-1305, 2016), Training 35% (T35%), Training 55% (T55%), Zataria (Özgünen et al. in Scand J Med Sci Sports 20:140-147, 2010), Zataria/Training 35% (ZT35%), and Zataria/Training 55% (ZT55%). Resist-ance training program included 12 exercise stations (each: 30 s, intensity: 35% and 55% of 1-RM) for 8 weeks (3 sessions/week). Daily (500 mg) was used after breakfast by participants in , ZT35%, and ZT55% groups. Blood samples were taken 48 h before and after the first and last sessions of training.

Results: After the training period the percentage of body fat decreased significantly ( < 0.001) in all trained groups, whereas muscle mass increased significantly ( < 0.01) only in T55% and ZT55% groups. A significant decrease was observed for RBP-4 values ( < 0.05) after training in all groups except for ZG and CG. Also, RBP-4 was significantly lower ( < 0.05) in all groups as compared to CG at the post-test except for ZG. Moreover, significantly lower values ( < 0.05) were found in T55%, ZT35%, and ZT55% as compared to ZG in post-intervention. TNF-α values decreased significantly ( < 0.05) at the post-test as compared to pre-intervention in ZT35% and ZT55%. Also, TNF-α was significantly lower ( < 0.05) in ZT55% compared to CG and T35% in post-test.

Conclusions: The results demonstrate clearly that in postmenopausal women, circuit resistance training both at low and moderate intensities cause a greater reduction in RBP-4 and TNF-α when is supplemented in the diet during training.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1007/s11332-019-00544-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6934256PMC
December 2019

The thyroid axis, prolactin, and exercise in humans.

Curr Opin Endocr Metab Res 2019 Dec 5;9:45-50. Epub 2019 Jul 5.

Department of Biological Sciences in Sport, Faculty of Sports Sciences and Health Shahid Beheshti University, Tehran, Iran.

The thyroid hormones thyroxine and triiodothyronine as well as the anterior pituitary hormone prolactin each serve vital roles in humans. When challenged by stressful situations, all of these hormones respond in an attempt to maintain homeostasis. One powerful stressor to invoke the release of these hormones is physical activity, that is, exercise. The thyroids and prolactin each have independent roles allowing the body to accommodate to exercise. But they also share an interrelation in their responses. Hypothalamic thyrotropin-releasing hormone release invoked by stress stimulates the release of thyroid-stimulating hormone and thus the thyroids as well as the release of prolactin. Likewise, estrogen serves as an interconnective regulatory link by stimulating the release of both the thyroids and prolactin. The roles of these hormones in exercise are multifaceted, but one overlapping and common function is their combined aid and support of the tissue inflammatory responses after exercise. This is highly critical for facilitating elements of the adaptive-recovery procedures to exercise and exercise training.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.coemr.2019.06.012DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6720127PMC
December 2019

The TNF-α, P53 protein response and lung respiratory changes to exercise, chronic hypoxia and Adiantum capillus-veneris supplementation.

Adv Respir Med 2019 ;87(4):226-234

Université de Rennes, M2S, Laboratoire Mouvement, Sport, Santé, Rennes, France.

Introduction: Evidence suggests that hypoxia and high-intensity exercise training can increase apoptosis of lung cells and Adiantum capillus-veneris (Ac-v) extract can have anti-apoptotic effects. Thus, the aim of the present study was to investigate the effect of chronic hypoxia and the (Ac-v) extraction as a supplement on TNF-a and P53 protein expression as well as the respiratory surface.

Material And Methods: 24 healthy Wistar rats (age = 4 weeks, weight = 72 = 9 gr) were trained using interval training for 6 weeks followed by a 3-week stay in hypoxia conditions. Half of the hypoxia samples received 500 ml/gr/per body weight daily (Ac-v) within 3 weeks of hypoxia. At the end, the lung tissue was removed for histological and immunohistological analysis.

Results: After 3 weeks of hypoxia exposure following 6 weeks of exercise, expression of P53 and TNF-a increased and the respiratory surface decreased (p ≤ 0.05). After 3 weeks of taking the Ac-v extract during hypoxia exposure, reduced P53 and TNF-a expression and the increased respiratory surface were observed (p ≤ 0.05).

Conclusions: Chronic hypoxia may be considered as a strong stimulus leading to the expression of proteins involved in apoptosis and tissue disruption. However, our findings suggest that the antioxidative properties of Ac-v extract could decrease the destructive structural and molecular events that happen along with hypoxia exposure or intense exercise training.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.5603/ARM.2019.0037DOI Listing
February 2020

Supplementation of Modulates Alveolar Apoptosis under Hypoxia Condition in Wistar Rats Exposed to Exercise.

Medicina (Kaunas) 2019 Jul 23;55(7). Epub 2019 Jul 23.

Laboratoire M2S, University of Rennes, EA 1274, F-35000 Rennes, France.

Several studies have reported that some conditions such as exercise and hypoxia induce DNA damage and dysfunction and apoptosis. Some plant foods contain numerous bioactive compounds and anti-inflammatory properties that can help fight DNA damage. Therefore, the current study evaluated the effect of supplementation of Adiantum capillus-veneris (ACV) extract on Bax/B-cell lymphoma 2 (Bcl-2) ratio apoptotic index and remodeling of pulmonary alveolar epithelial cells in lung tissue of healthy Wistar rats during stressful conditions (hypoxia). Twenty-seven Wistar male rats (four-week old, 72 ± 9 g) were randomly assigned into three groups: normoxic, sedentary, and not-supplemented (NG, = 9); exercise and hypoxia and not-supplemented (HE, = 9); and exercise and hypoxia and supplemented group (HS, = 9). The NG remained sedentary in the normoxia environment for nine weeks. The HE group participated in a high-intensity (IT) program for six weeks, then remained sedentary in the hypoxia environment for three weeks. The low-pressure chamber simulated a ~2800 M altitude 24 h/d. HS participated in IT, then entered and remained sedentary in the hypoxia environment for three weeks, and they consumed 500 mg per kg of body weight ACV extract. : The Bax/Bcl-2 ratio of the HE group increased significantly (+50.27%, ≤ 0.05), the average number of type I pneumocytes was reduced significantly (-18.85%, ≤ 0.05), and the average number of type II pneumocytes was increased significantly (+14.69%, ≤ 0.05). Also, after three weeks of consuming the ACV extract, the HS group in comparison with the HE group had their Bax/Bcl-2 ratio reduced significantly (-24.27%, ≤ 0.05), the average number of type I pneumocytes increased significantly (+10.15%, ≤ 0.05), and the average number of type II pneumocytes reduced significantly (-7.18%, ≤ 0.05). The findings show that after three weeks of hypoxia following six weeks of high-intensity interval training in Wistar rats, the Bax/Bcl-2 ratio and the number of type II pneumocytes were increased and the number of type I pneumocytes was reduced significantly. These results strongly suggest that an apoptosis state was induced in the lung parenchyma, and consuming ACV extract modulated this state.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.3390/medicina55070401DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6681305PMC
July 2019

Diabetes, Insulin Resistance, Fetuin-B and Exercise Training.

Ann Appl Sport Sci 2019 ;7(2):1-2

Movement, Sport and Health Sciences laboratory (M2S), University of Rennes 2, Rennes, France.

View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.29252/aassjournal.7.2.1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6639044PMC
January 2019

Effects of exercise training on type 2-diabetes: the role of Meteorin-like protein.

Health Promot Perspect 2019 25;9(2):89-91. Epub 2019 May 25.

Movement, Sport and Health Sciences laboratory (M2S), University of Rennes 2, Rennes, France.

View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.15171/hpp.2019.12DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6588808PMC
May 2019

Effect of physical exercise and training on gastrointestinal hormones in populations with different weight statuses.

Nutr Rev 2019 07;77(7):455-477

Laboratory of Biomonitoring of the Environment, Faculty of Science of Bizerte, University of Carthage, Carthage, Tunisia.

Several types of hormones exert control over appetite in humans. This narrative review explores the effects of exercise and training on the concentrations of gastrointestinal hormones in healthy and obese individuals. It focuses on the major hormones of appetite regulation: ghrelin, glucagon-like peptide 1, peptide YY, cholecystokinin, leptin, and oxyntomodulin. In normal-weight and overweight individuals, responses to most of these hormones depend on the intensity of exercise and training. However, findings in obese individuals are limited in number and, to some degree, contradictory. Although some gastrointestinal hormones have been studied extensively (eg, leptin), most have not been investigated systematically. Further research is required to confirm the effectiveness of exercise and training on gut hormones and to better understand the effect of gut hormones on appetite and hunger suppression in individuals with obesity. Investigations to elucidate the impact of various forms of exercise that have recently engaged the public interest, eg, high-intensity interval training or concurrent aerobic and resistance training, are warranted.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1093/nutrit/nuz005DOI Listing
July 2019

Independent and Combined Effects of Antioxidant Supplementation and Circuit Resistance Training on Selected Adipokines in Postmenopausal Women.

Front Physiol 2019 26;10:484. Epub 2019 Apr 26.

Movement Sports Science Laboratory, University of Rennes, Rennes, France.

We examined the effects of the independent and combined effects of Zataria Multiflora supplementation and circuit resistance training (CRT) on selected adipokines among postmenopausal women. Forty-eight postmenopausal women were divided into four groups: Exercise (EG, = 12), Zataria Multiflora (ZMG, = 12), exercise and Zataria Multiflora (ZMEG, = 12), and control (CG, = 12). Participants in experimental groups either performed CRT (3 sessions per week with intensity at 55% of one-repetition maximum) or supplemented with Zataria Multiflora (500 mg every day after breakfast with 100 ml of water), or their combination, for 8 weeks. Blood samples were collected at pre- and post-intervention for measuring selected adipokines, including visfatin, omentin-1, vaspin, FGF-21, adiponectin, leptin, and ghrelin. Our findings demonstrated that visfatin, vaspin, and leptin levels significantly decreased over the intervention period (all < 0.05), with these values were lower in EG and ZMEG in comparison to CG at post-intervention (all < 0.05). Visfatin and vaspin levels were also lower in ZMEG in comparison to EG at post-intervention (both < 0.05). In contrast, omentin-1, ghrelin, adiponectin, and FGF21 significantly increased in EG and EMG (all < 0.05) after CRT. These findings suggest that Zataria Multiflora supplementation by itself has little effect on measured adipokines; however, its combination with CRT produced noticeable effects on circulating levels of these adipokines, even more than CRT alone. Consequently, a combination of CRT and Zataria Multiflora supplementation may represent a potentially beneficial non-pharmacologic intervention on some selected adipokines in postmenopausal women.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.3389/fphys.2019.00484DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6499001PMC
April 2019

Effects of polyphenol (carob) supplementation on body composition and aerobic capacity in taekwondo athletes.

Physiol Behav 2019 06 7;205:22-28. Epub 2019 Mar 7.

Higher Institute of Sport and Physical Education of Ksar Said, University of "La Manouba", Tunis, Tunisia.

Herbal products and supplements use by athletes has increased over the past decade. One such item being polyphenols. These are reported to reduce weight and modify body composition, which could aid athletes in many sports. Therefore, the purpose of the study was to determine the effect of 6 weeks supplementation with carob, a naturally occurring polyphenol, on body composition and aerobic capacity in youth taekwondo athletes. Twenty-three taekwondo athletes (21.9 ± 1.2 years; 1.64 ± 0.03 m; 67.4 ± 17.3 kg;BMI: 22.8 ± 5.5 kg/m) participated in a short-term (6-week) double-blind randomized design parallel fully controlled training study (pre-to-post measurements): Supplemented group (SG), n = 11;placebo group (PG), n = 12. Body composition, aerobic capacity, heart rate and RPE were analyzed before and after 6 weeks of carob rich polyphenol ingestion. Significantly greater decreases in weight were observed for SG and PG (-2.82% and - 0.51%respectively) with differences between groups (p < 0.001). No significant differences were reported in percentage body fat and muscular volume between groups. Our results revealed an improvement of aerobic performance score and RPE with differences between groups. A cute polyphenol supplementation seemed to be effective in reducing body weight and improving aerobic performance in athletes.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.physbeh.2019.03.003DOI Listing
June 2019

Progressive circuit resistance training improves inflammatory biomarkers and insulin resistance in obese men.

Physiol Behav 2019 06 29;205:15-21. Epub 2018 Nov 29.

Univ Rennes, M2S (Laboratoire Mouvement, Sport, Santé) - EA 1274, F-35000 Rennes, France. Electronic address:

Background: Circuit resistance training (CRT) is a time-efficient exercise modality for improving skeletal muscle and cardiovascular fitness. But the beneficial role of CRT in obese individuals is still not well understood. This study explores the reducing effects of progressive CRT on inflammatory biomarkers and cardiometabolic risk factors in obese young men.

Methods: Thirty obese men (Body mass index (BMI): 30.67 ± 3.06; age: 23 ± 3.2 years) were divided into CRT and control groups. The CRT was performed for eight-weeks (3 times/week, 65-85% of 1 repetition maximum). Fasting blood samples were taken pre and post intervention for analyzing apelin, chemerin, serum amyloid A (SAA), C reactive protein concentrations (CRP), lipid profile, and insulin resistance index. The data were assessed by two-way repeated measures ANOVA.

Results: Body mass, BMI and waist to hip ratio (WHR) were significantly decreased after training intervention (P < .05). Compared to the control group, the plasma concentrations of Chemrin (P = .038), SAA (P = .004), insulin (P < .001), insulin resistance index (P < .001), total cholesterol (P = .033), triglyceride (P < .001), and low-density lipoprotein (P = .039), were significantly mitigated in the CRT group, but high-density lipoprotein plasma levels increased in the CRT group compared to that of the control group (P = .035). There was no significant difference between two groups in apelin and CRP (P > .05). Moreover, insulin resistance was positively correlated with apelin (r = 0.56) and chemerin (r = 0.51). Also, chemerin had a positive correlation with SAA (r = 0.49), and WHR (r = 0.54).

Conclusion: CRT caused an improvement in inflammation and cardiometabolic risk factors in young obese men, and this improvement was accompanied by decreased insulin resistance.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.physbeh.2018.11.033DOI Listing
June 2019

The combination of exercise training and supplementation increase serum irisin levels in postmenopausal women.

Integr Med Res 2018 Mar 31;7(1):44-52. Epub 2018 Jan 31.

School of Health Sciences, University of Tasmania, Launceston, Australia.

Background: We examined the effect of antioxidant supplementation and exercise on irisin within postmenopausal women.

Methods: Forty-eight participants (age: 55.7 ± 4.9 years; weight: 68.0 ± 6.3 kg; BMI 27.0 ± 2.7; mean ± SD) were randomized into four groups for the eight week intervention: control group (CG;  = 12), resistance training group (RTG;  = 12), supplementation with group (ZG;  = 12), or supplementation with and resistance training group (ZRTG;  = 12). RTG and ZRTG performed circuit resistance training, and both ZG and ZRTG consumed 500 mg of every day during the intervention. Blood samples were taken 48 hours before and after the intervention.

Results: There was a significant difference in irisin at post-training, with greater levels in ZRTG compared to CG. A significant increase was noted for irisin at post-training compared to pre-training for ZG, RTG, and ZRTG. Moreover, we identified a significant decrease in malondialdehyde in the RTG and ZRTG groups and increase in glutathione in the ZG, RTG, and ZRTG groups when compared to CG.

Conclusion: These findings showed that exercise, supplementation or their combination led to an increase in irisin.
View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.imr.2018.01.007DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5884011PMC
March 2018

Exercise Training, Neuregulin 4 and Obesity.

Ann Appl Sport Sci 2017 ;5(2):1-2

Department of Exercise & Sport Science, University of North Carolina, Chapel Hill, NC, United States.

View Article and Find Full Text PDF

Download full-text PDF

Source
http://dx.doi.org/10.18869/acadpub.aassjournal.5.2.1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6424364PMC
January 2017
-->