Publications by authors named "Ayman H Fanous"

54Publications

Genome-Wide Association Studies of Schizophrenia and Bipolar Disorder in a Diverse Cohort of US Veterans.

Authors:
Tim B Bigdeli Ayman H Fanous Yuli Li Nallakkandi Rajeevan Frederick Sayward Giulio Genovese Rishab Gupta Krishnan Radhakrishnan Anil K Malhotra Ning Sun Qiongshi Lu Yiming Hu Boyang Li Quan Chen Shrikant Mane Perry Miller Kei-Hoi Cheung Raquel E Gur Tiffany A Greenwood David L Braff Eric D Achtyes Peter F Buckley Michael A Escamilla Douglas Lehrer Dolores P Malaspina Steven A McCarroll Mark H Rapaport Marquis P Vawter Michele T Pato Carlos N Pato Hongyu Zhao Thomas R Kosten Mary Brophy Saiju Pyarajan Yunling Shi Timothy J O'Leary Theresa Gleason Ronald Przygodzki Sumitra Muralidhar J Michael Gaziano Grant D Huang John Concato Larry J Siever Mihaela Aslan Philip D Harvey

Schizophr Bull 2020 Nov 10. Epub 2020 Nov 10.

Research Service Bruce W. Carter VA Medical Center, Miami, FL.

View Article and Find Full Text PDF
November 2020

Support Groups and Individual Mental Health Care via Video Conferencing for Frontline Clinicians During the COVID-19 Pandemic.

Authors:
Ramaswamy Viswanathan Michael F Myers Ayman H Fanous

Psychosomatics 2020 Sep - Oct;61(5):538-543. Epub 2020 Jun 23.

Department of Psychiatry and Behavioral Sciences, State University of New York Downstate Health Sciences University, Brooklyn, NY.

View Article and Find Full Text PDF
October 2020

Genome-wide association study of cognitive performance in U.S. veterans with schizophrenia or bipolar disorder.

Authors:
Philip D Harvey Ning Sun Tim B Bigdeli Ayman H Fanous Mihaela Aslan Anil K Malhotra Qiongshi Lu Yiming Hu Boyang Li Quan Chen Shrikant Mane Perry Miller Nallakkandi Rajeevan Frederick Sayward Kei-Hoi Cheung Yuli Li Tiffany A Greenwood Raquel E Gur David L Braff Mary Brophy Saiju Pyarajan Timothy J O'Leary Theresa Gleason Ronald Przygodszki Sumitra Muralidhar J Michael Gaziano John Concato Hongyu Zhao Larry J Siever

Am J Med Genet B Neuropsychiatr Genet 2020 04 24;183(3):181-194. Epub 2019 Dec 24.

James J. Peters Veterans Affairs Medical Center, Bronx, New York.

View Article and Find Full Text PDF
April 2020

Contributions of common genetic variants to risk of schizophrenia among individuals of African and Latino ancestry.

Authors:
Tim B Bigdeli Giulio Genovese Penelope Georgakopoulos Jacquelyn L Meyers Roseann E Peterson Conrad O Iyegbe Helena Medeiros Jorge Valderrama Eric D Achtyes Roman Kotov Eli A Stahl Colony Abbott Maria Helena Azevedo Richard A Belliveau Elizabeth Bevilacqua Evelyn J Bromet William Byerley Celia Barreto Carvalho Sinéad B Chapman Lynn E DeLisi Ashley L Dumont Colm O'Dushlaine Oleg V Evgrafov Laura J Fochtmann Diane Gage James L Kennedy Becky Kinkead Antonio Macedo Jennifer L Moran Christopher P Morley Mantosh J Dewan James Nemesh Diana O Perkins Shaun M Purcell Jeffrey J Rakofsky Edward M Scolnick Brooke M Sklar Pamela Sklar Jordan W Smoller Patrick F Sullivan Fabio Macciardi Stephen R Marder Ruben C Gur Raquel E Gur David L Braff Humberto Nicolini Michael A Escamilla Marquis P Vawter Janet L Sobell Dolores Malaspina Douglas S Lehrer Peter F Buckley Mark H Rapaport James A Knowles Ayman H Fanous Michele T Pato Steven A McCarroll Carlos N Pato

Mol Psychiatry 2020 10 7;25(10):2455-2467. Epub 2019 Oct 7.

Department of Psychiatry and Behavioral Sciences, SUNY Downstate Medical Center, Brooklyn, NY, USA.

View Article and Find Full Text PDF
October 2020

Contributions of common genetic variants to risk of schizophrenia among individuals of African and Latino ancestry.

Authors:
Tim B Bigdeli Giulio Genovese Penelope Georgakopoulos Jacquelyn L Meyers Roseann E Peterson Conrad O Iyegbe Helena Medeiros Jorge Valderrama Eric D Achtyes Roman Kotov Eli A Stahl Colony Abbott Maria Helena Azevedo Richard A Belliveau Elizabeth Bevilacqua Evelyn J Bromet William Byerley Celia Barreto Carvalho Sinéad B Chapman Lynn E DeLisi Ashley L Dumont Colm O'Dushlaine Oleg V Evgrafov Laura J Fochtmann Diane Gage James L Kennedy Becky Kinkead Antonio Macedo Jennifer L Moran Christopher P Morley Mantosh J Dewan James Nemesh Diana O Perkins Shaun M Purcell Jeffrey J Rakofsky Edward M Scolnick Brooke M Sklar Pamela Sklar Jordan W Smoller Patrick F Sullivan Fabio Macciardi Stephen R Marder Ruben C Gur Raquel E Gur David L Braff Humberto Nicolini Michael A Escamilla Marquis P Vawter Janet L Sobell Dolores Malaspina Douglas S Lehrer Peter F Buckley Mark H Rapaport James A Knowles Ayman H Fanous Michele T Pato Steven A McCarroll Carlos N Pato

Mol Psychiatry 2020 10 7;25(10):2455-2467. Epub 2019 Oct 7.

Department of Psychiatry and Behavioral Sciences, SUNY Downstate Medical Center, Brooklyn, NY, USA.

View Article and Find Full Text PDF
October 2020

Contribution of Rare Copy Number Variants to Bipolar Disorder Risk Is Limited to Schizoaffective Cases.

Authors:
Alexander W Charney Eli A Stahl Elaine K Green Chia-Yen Chen Jennifer L Moran Kimberly Chambert Richard A Belliveau Liz Forty Katherine Gordon-Smith Phil H Lee Evelyn J Bromet Peter F Buckley Michael A Escamilla Ayman H Fanous Laura J Fochtmann Douglas S Lehrer Dolores Malaspina Stephen R Marder Christopher P Morley Humberto Nicolini Diana O Perkins Jeffrey J Rakofsky Mark H Rapaport Helena Medeiros Janet L Sobell Lena Backlund Sarah E Bergen Anders Juréus Martin Schalling Paul Lichtenstein James A Knowles Katherine E Burdick Ian Jones Lisa A Jones Christina M Hultman Roy Perlis Shaun M Purcell Steven A McCarroll Carlos N Pato Michele T Pato Ariana Di Florio Nick Craddock Mikael Landén Jordan W Smoller Douglas M Ruderfer Pamela Sklar

Biol Psychiatry 2019 07 20;86(2):110-119. Epub 2018 Dec 20.

Department of Psychiatry, Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, New York; Department of Neuroscience, Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, New York; Department of Genetics and Genomic Sciences, Icahn Institute of Genomics and Multiscale Biology, New York, New York.

View Article and Find Full Text PDF
July 2019

Convergent roles of de novo mutations and common variants in schizophrenia in tissue-specific and spatiotemporal co-expression network.

Authors:
Peilin Jia Xiangning Chen Ayman H Fanous Zhongming Zhao

Transl Psychiatry 2018 05 24;8(1):105. Epub 2018 May 24.

Center for Precision Health, School of Biomedical Informatics, The University of Texas Health Science Center at Houston, Houston, TX, USA.

View Article and Find Full Text PDF
May 2018

Identification of shared genetic variants between schizophrenia and lung cancer.

Authors:
Verena Zuber Erik G Jönsson Oleksandr Frei Aree Witoelar Wesley K Thompson Andrew J Schork Francesco Bettella Yunpeng Wang Srdjan Djurovic Olav B Smeland Ingrid Dieset Ayman H Fanous Rahul S Desikan Sébastien Küry Stéphane Bézieau Anders M Dale Ian G Mills Ole A Andreassen

Sci Rep 2018 01 12;8(1):674. Epub 2018 Jan 12.

NORMENT, KG Jebsen Centre for Psychosis Research, Institute of Clinical Medicine, University of Oslo, Oslo, Norway.

View Article and Find Full Text PDF
January 2018

Cross-Disorder Psychiatric Genomics.

Authors:
Anna R Docherty Arden A Moscati Ayman H Fanous

Curr Behav Neurosci Rep 2016 Sep 2;3(3):256-263. Epub 2016 Jul 2.

Virginia Institute for Psychiatric and Behavioral Genetics, Virginia Commonwealth University School of Medicine, Richmond, VA, USA; Washington Veterans Affairs Healthcare System, Washington D.C., USA; Georgetown University School of Medicine, Washington D.C., USA.

View Article and Find Full Text PDF
September 2016

Contribution of copy number variants to schizophrenia from a genome-wide study of 41,321 subjects.

Authors:
Christian R Marshall Daniel P Howrigan Daniele Merico Bhooma Thiruvahindrapuram Wenting Wu Douglas S Greer Danny Antaki Aniket Shetty Peter A Holmans Dalila Pinto Madhusudan Gujral William M Brandler Dheeraj Malhotra Zhouzhi Wang Karin V Fuentes Fajarado Michelle S Maile Stephan Ripke Ingrid Agartz Margot Albus Madeline Alexander Farooq Amin Joshua Atkins Silviu A Bacanu Richard A Belliveau Sarah E Bergen Marcelo Bertalan Elizabeth Bevilacqua Tim B Bigdeli Donald W Black Richard Bruggeman Nancy G Buccola Randy L Buckner Brendan Bulik-Sullivan William Byerley Wiepke Cahn Guiqing Cai Murray J Cairns Dominique Campion Rita M Cantor Vaughan J Carr Noa Carrera Stanley V Catts Kimberley D Chambert Wei Cheng C Robert Cloninger David Cohen Paul Cormican Nick Craddock Benedicto Crespo-Facorro James J Crowley David Curtis Michael Davidson Kenneth L Davis Franziska Degenhardt Jurgen Del Favero Lynn E DeLisi Dimitris Dikeos Timothy Dinan Srdjan Djurovic Gary Donohoe Elodie Drapeau Jubao Duan Frank Dudbridge Peter Eichhammer Johan Eriksson Valentina Escott-Price Laurent Essioux Ayman H Fanous Kai-How Farh Martilias S Farrell Josef Frank Lude Franke Robert Freedman Nelson B Freimer Joseph I Friedman Andreas J Forstner Menachem Fromer Giulio Genovese Lyudmila Georgieva Elliot S Gershon Ina Giegling Paola Giusti-Rodríguez Stephanie Godard Jacqueline I Goldstein Jacob Gratten Lieuwe de Haan Marian L Hamshere Mark Hansen Thomas Hansen Vahram Haroutunian Annette M Hartmann Frans A Henskens Stefan Herms Joel N Hirschhorn Per Hoffmann Andrea Hofman Hailiang Huang Masashi Ikeda Inge Joa Anna K Kähler René S Kahn Luba Kalaydjieva Juha Karjalainen David Kavanagh Matthew C Keller Brian J Kelly James L Kennedy Yunjung Kim James A Knowles Bettina Konte Claudine Laurent Phil Lee S Hong Lee Sophie E Legge Bernard Lerer Deborah L Levy Kung-Yee Liang Jeffrey Lieberman Jouko Lönnqvist Carmel M Loughland Patrik K E Magnusson Brion S Maher Wolfgang Maier Jacques Mallet Manuel Mattheisen Morten Mattingsdal Robert W McCarley Colm McDonald Andrew M McIntosh Sandra Meier Carin J Meijer Ingrid Melle Raquelle I Mesholam-Gately Andres Metspalu Patricia T Michie Lili Milani Vihra Milanova Younes Mokrab Derek W Morris Bertram Müller-Myhsok Kieran C Murphy Robin M Murray Inez Myin-Germeys Igor Nenadic Deborah A Nertney Gerald Nestadt Kristin K Nicodemus Laura Nisenbaum Annelie Nordin Eadbhard O'Callaghan Colm O'Dushlaine Sang-Yun Oh Ann Olincy Line Olsen F Anthony O'Neill Jim Van Os Christos Pantelis George N Papadimitriou Elena Parkhomenko Michele T Pato Tiina Paunio Diana O Perkins Tune H Pers Olli Pietiläinen Jonathan Pimm Andrew J Pocklington John Powell Alkes Price Ann E Pulver Shaun M Purcell Digby Quested Henrik B Rasmussen Abraham Reichenberg Mark A Reimers Alexander L Richards Joshua L Roffman Panos Roussos Douglas M Ruderfer Veikko Salomaa Alan R Sanders Adam Savitz Ulrich Schall Thomas G Schulze Sibylle G Schwab Edward M Scolnick Rodney J Scott Larry J Seidman Jianxin Shi Jeremy M Silverman Jordan W Smoller Erik Söderman Chris C A Spencer Eli A Stahl Eric Strengman Jana Strohmaier T Scott Stroup Jaana Suvisaari Dragan M Svrakic Jin P Szatkiewicz Srinivas Thirumalai Paul A Tooney Juha Veijola Peter M Visscher John Waddington Dermot Walsh Bradley T Webb Mark Weiser Dieter B Wildenauer Nigel M Williams Stephanie Williams Stephanie H Witt Aaron R Wolen Brandon K Wormley Naomi R Wray Jing Qin Wu Clement C Zai Rolf Adolfsson Ole A Andreassen Douglas H R Blackwood Elvira Bramon Joseph D Buxbaum Sven Cichon David A Collier Aiden Corvin Mark J Daly Ariel Darvasi Enrico Domenici Tõnu Esko Pablo V Gejman Michael Gill Hugh Gurling Christina M Hultman Nakao Iwata Assen V Jablensky Erik G Jönsson Kenneth S Kendler George Kirov Jo Knight Douglas F Levinson Qingqin S Li Steven A McCarroll Andrew McQuillin Jennifer L Moran Bryan J Mowry Markus M Nöthen Roel A Ophoff Michael J Owen Aarno Palotie Carlos N Pato Tracey L Petryshen Danielle Posthuma Marcella Rietschel Brien P Riley Dan Rujescu Pamela Sklar David St Clair James T R Walters Thomas Werge Patrick F Sullivan Michael C O'Donovan Stephen W Scherer Benjamin M Neale Jonathan Sebat

Nat Genet 2017 01 21;49(1):27-35. Epub 2016 Nov 21.

Beyster Center for Psychiatric Genomics, University of California, San Diego, La Jolla, California, USA.

View Article and Find Full Text PDF
January 2017

A simple yet accurate correction for winner's curse can predict signals discovered in much larger genome scans.

Authors:
T Bernard Bigdeli Donghyung Lee Bradley Todd Webb Brien P Riley Vladimir I Vladimirov Ayman H Fanous Kenneth S Kendler Silviu-Alin Bacanu

Bioinformatics 2016 09 13;32(17):2598-603. Epub 2016 May 13.

Department of Psychiatry, Virginia Institute for Psychiatric and Behavioral Genetics.

View Article and Find Full Text PDF
September 2016

Genome-wide association study reveals greater polygenic loading for schizophrenia in cases with a family history of illness.

Authors:
Tim B Bigdeli Stephan Ripke Silviu-Alin Bacanu Sang Hong Lee Naomi R Wray Pablo V Gejman Marcella Rietschel Sven Cichon David St Clair Aiden Corvin George Kirov Andrew McQuillin Hugh Gurling Dan Rujescu Ole A Andreassen Thomas Werge Douglas H R Blackwood Carlos N Pato Michele T Pato Anil K Malhotra Michael C O'Donovan Kenneth S Kendler Ayman H Fanous

Am J Med Genet B Neuropsychiatr Genet 2016 Mar 11;171B(2):276-89. Epub 2015 Dec 11.

Virginia Institute for Psychiatric and Behavioral Genetics, Department of Psychiatry, Virginia Commonwealth University, Richmond, Virginia.

View Article and Find Full Text PDF
March 2016

JEPEGMIX: gene-level joint analysis of functional SNPs in cosmopolitan cohorts.

Authors:
Donghyung Lee Vernell S Williamson T Bernard Bigdeli Brien P Riley Bradley T Webb Ayman H Fanous Kenneth S Kendler Vladimir I Vladimirov Silviu-Alin Bacanu

Bioinformatics 2016 Jan 1;32(2):295-7. Epub 2015 Oct 1.

Department of Psychiatry, Virginia Commonwealth University, Richmond, VA 23298, USA.

View Article and Find Full Text PDF
January 2016

Meta-analysis of Positive and Negative Symptoms Reveals Schizophrenia Modifier Genes.

Authors:
Alexis C Edwards Tim B Bigdeli Anna R Docherty Silviu Bacanu Donghyung Lee Teresa R de Candia Arden Moscati Dawn L Thiselton Brion S Maher Brandon K Wormley Dermot Walsh Francis A O'Neill Kenneth S Kendler Brien P Riley Ayman H Fanous

Schizophr Bull 2016 Mar 27;42(2):279-87. Epub 2015 Aug 27.

Virginia Institute for Psychiatric and Behavioral Genetics, Department of Psychiatry, Virginia Commonwealth University School of Medicine, Richmond, VA; Mental Health Service Line, Washington VA Medical Center, Washington, DC; Department of Psychiatry, Georgetown University School of Medicine, Washington, DC.

View Article and Find Full Text PDF
March 2016

DISTMIX: direct imputation of summary statistics for unmeasured SNPs from mixed ethnicity cohorts.

Authors:
Donghyung Lee T Bernard Bigdeli Vernell S Williamson Vladimir I Vladimirov Brien P Riley Ayman H Fanous Silviu-Alin Bacanu

Bioinformatics 2015 Oct 9;31(19):3099-104. Epub 2015 Jun 9.

Department of Psychiatry, Virginia Institute for Psychiatric and Behavioral Genetics, Virginia Commonwealth University, Richmond, VA 23298, USA.

View Article and Find Full Text PDF
October 2015

Can genomics help usher schizophrenia into the age of RDoC and DSM-6?

Authors:
Ayman H Fanous

Schizophr Bull 2015 May;41(3):535-41

Mental Health Service Line, Washington VA Medical Center, Washington, DC; Department of Psychiatry, Georgetown University School of Medicine, Washington, DC

View Article and Find Full Text PDF
May 2015

Genome-wide gene pathway analysis of psychotic illness symptom dimensions based on a new schizophrenia-specific model of the OPCRIT.

Authors:
Anna R Docherty T Bernard Bigdeli Alexis C Edwards Silviu Bacanu Donghyung Lee Michael C Neale Brandon K Wormley Dermot Walsh F Anthony O'Neill Brien P Riley Kenneth S Kendler Ayman H Fanous

Schizophr Res 2015 May 13;164(1-3):181-6. Epub 2015 Mar 13.

Virginia Institute for Psychiatric and Behavioral Genetics, Virginia Commonwealth, University School of Medicine, VA, USA; Washington Veterans Affairs Healthcare System, Washington D.C. USA; Georgetown University School of Medicine, Washington D.C. USA.

View Article and Find Full Text PDF
May 2015

JEPEG: a summary statistics based tool for gene-level joint testing of functional variants.

Authors:
Donghyung Lee Vernell S Williamson T Bernard Bigdeli Brien P Riley Ayman H Fanous Vladimir I Vladimirov Silviu-Alin Bacanu

Bioinformatics 2015 Apr 12;31(8):1176-82. Epub 2014 Dec 12.

Department of Psychiatry, Virginia Institute for Psychiatric and Behavioral Genetics, Center for Biomarker Research & Personalized Medicine, Virginia Commonwealth University, Richmond, VA 23298, USA and Lieber Institute for Brain Development, Johns Hopkins University, Baltimore, MD 21205, USA.

View Article and Find Full Text PDF
April 2015

Uncovering the hidden risk architecture of the schizophrenias: confirmation in three independent genome-wide association studies.

Authors:
Javier Arnedo Dragan M Svrakic Coral Del Val Rocío Romero-Zaliz Helena Hernández-Cuervo Ayman H Fanous Michele T Pato Carlos N Pato Gabriel A de Erausquin C Robert Cloninger Igor Zwir

Am J Psychiatry 2015 Feb 31;172(2):139-53. Epub 2014 Oct 31.

From the Department of Psychiatry and the Department of Genetics, Washington University School of Medicine, St. Louis; the Department of Computer Science and Artificial Intelligence, University of Granada, Granada, Spain; St. Louis VA Medical Center, St. Louis; Roskamp Laboratory of Brain Development, Modulation, and Repair, Department of Psychiatry and Behavioral Neurosciences, University of South Florida, Tampa; Washington DC VA Medical Center, Washington, D.C.; and the Department of Psychiatry, University of Southern California, Los Angeles.

View Article and Find Full Text PDF
February 2015

Genetic modifiers and subtypes in schizophrenia: investigations of age at onset, severity, sex and family history.

Authors:
Sarah E Bergen Colm T O'Dushlaine Phil H Lee Ayman H Fanous Douglas M Ruderfer Stephan Ripke Patrick F Sullivan Jordan W Smoller Shaun M Purcell Aiden Corvin

Schizophr Res 2014 Apr 26;154(1-3):48-53. Epub 2014 Feb 26.

Neuropsychiatric Genetics Research Group, Department of Psychiatry and Institute of Molecular Medicine, Trinity College Dublin, Dublin 2, Ireland.

View Article and Find Full Text PDF
April 2014

Polygenic dissection of diagnosis and clinical dimensions of bipolar disorder and schizophrenia.

Authors:
Douglas M Ruderfer Ayman H Fanous Stephan Ripke Andrew McQuillin Richard L Amdur Pablo V Gejman Michael C O'Donovan Ole A Andreassen Srdjan Djurovic Christina M Hultman John R Kelsoe Stephane Jamain Mikael Landén Marion Leboyer Vishwajit Nimgaonkar John Nurnberger Jordan W Smoller Nick Craddock Aiden Corvin Patrick F Sullivan Peter Holmans Pamela Sklar Kenneth S Kendler

Mol Psychiatry 2014 Sep 26;19(9):1017-1024. Epub 2013 Nov 26.

Department of Psychiatry, Virginia Commonwealth University School of Medicine, Richmond, Virginia, USA.

View Article and Find Full Text PDF
September 2014

Association study of 83 candidate genes for bipolar disorder in chromosome 6q selected using an evidence-based prioritization algorithm.

Authors:
T Bernard Bigdeli Brion S Maher Zhongming Zhao Jingchun Sun Helena Medeiros Nirmala Akula Francis J McMahon Celia Carvalho Susana R Ferreira Maria H Azevedo James A Knowles Michele T Pato Carlos N Pato Ayman H Fanous

Am J Med Genet B Neuropsychiatr Genet 2013 Dec 30;162B(8):898-906. Epub 2013 Sep 30.

Virginia Institute for Psychiatric and Behavioral Genetics, Virginia Commonwealth University, Richmond, Virginia.

View Article and Find Full Text PDF
December 2013

Characterization of schizophrenia adverse drug interactions through a network approach and drug classification.

Authors:
Jingchun Sun Min Zhao Ayman H Fanous Zhongming Zhao

Biomed Res Int 2013 9;2013:458989. Epub 2013 Sep 9.

Department of Biomedical Informatics, Vanderbilt University School of Medicine, Nashville, TN 37203, USA ; Center for Quantitative Sciences, Vanderbilt University Medical Center, Nashville, TN 37232, USA.

View Article and Find Full Text PDF
June 2014

DIST: direct imputation of summary statistics for unmeasured SNPs.

Authors:
Donghyung Lee T Bernard Bigdeli Brien P Riley Ayman H Fanous Silviu-Alin Bacanu

Bioinformatics 2013 Nov 28;29(22):2925-7. Epub 2013 Aug 28.

Department of Psychiatry, Virginia Institute for Psychiatric and Behavioral Genetics, Virginia Commonwealth University, Richmond, Virginia 23298, USA.

View Article and Find Full Text PDF
November 2013

Molecular validation of the schizophrenia spectrum.

Authors:
T Bernard Bigdeli Silviu-Alin Bacanu Bradley T Webb Dermot Walsh F Anthony O'Neill Ayman H Fanous Brien P Riley Kenneth S Kendler

Schizophr Bull 2014 Jan 22;40(1):60-5. Epub 2013 Aug 22.

*To whom correspondence should be addressed; Department of Psychiatry, Virginia Institute for Psychiatric and Behavioral Genetics of VCU, Box 980126, Richmond, VA 23298-0126, US; tel: (804)-828-8590, fax: (804)-828-1471, e-mail:

View Article and Find Full Text PDF
January 2014

Association study of 167 candidate genes for schizophrenia selected by a multi-domain evidence-based prioritization algorithm and neurodevelopmental hypothesis.

Authors:
Zhongming Zhao Bradley T Webb Peilin Jia T Bernard Bigdeli Brion S Maher Edwin van den Oord Sarah E Bergen Richard L Amdur Francis A O'Neill Dermot Walsh Dawn L Thiselton Xiangning Chen Carlos N Pato Brien P Riley Kenneth S Kendler Ayman H Fanous

PLoS One 2013 29;8(7):e67776. Epub 2013 Jul 29.

Department of Biomedical Informatics, Vanderbilt University School of Medicine, Nashville, Tennessee, USA.

View Article and Find Full Text PDF
February 2014

The genomic psychiatry cohort: partners in discovery.

Authors:
Michele T Pato Janet L Sobell Helena Medeiros Colony Abbott Brooke M Sklar Peter F Buckley Evelyn J Bromet Michael A Escamilla Ayman H Fanous Douglas S Lehrer Fabio Macciardi Dolores Malaspina Steve A McCarroll Stephen R Marder Jennifer Moran Christopher P Morley Humberto Nicolini Diana O Perkins Shaun M Purcell Mark H Rapaport Pamela Sklar Jordan W Smoller James A Knowles Carlos N Pato

Am J Med Genet B Neuropsychiatr Genet 2013 Jun 3;162B(4):306-12. Epub 2013 May 3.

Department of Psychiatry and the Behavioral Sciences, University of Southern California, Los Angeles, California, USA.

View Article and Find Full Text PDF
June 2013

Genome-wide association study of clinical dimensions of schizophrenia: polygenic effect on disorganized symptoms.

Authors:
Ayman H Fanous Baiyu Zhou Steven H Aggen Sarah E Bergen Richard L Amdur Jubao Duan Alan R Sanders Jianxin Shi Bryan J Mowry Ann Olincy Farooq Amin C Robert Cloninger Jeremy M Silverman Nancy G Buccola William F Byerley Donald W Black Robert Freedman Frank Dudbridge Peter A Holmans Stephan Ripke Pablo V Gejman Kenneth S Kendler Douglas F Levinson

Am J Psychiatry 2012 Dec;169(12):1309-17

Mental Health Service Line, Washington, DC, USA.

View Article and Find Full Text PDF
December 2012

Variants in the 15q25 gene cluster are associated with risk for schizophrenia and bipolar disorder.

Authors:
Kia J Jackson Ayman H Fanous Jingchun Chen Kenneth S Kendler Xiangning Chen

Psychiatr Genet 2013 Feb;23(1):20-8

Department of Psychiatry, Virginia Institute for Psychiatric and Behavioral Genetics, Virginia Commonwealth University, Richmond, Virginia 23219, USA.

View Article and Find Full Text PDF
February 2013

On schizophrenia as a "disease of humanity".

Authors:
T Bernard Bigdeli Ayman H Fanous Brien P Riley Mark Reimers Xiangning Chen Kenneth S Kendler Silviu-Alin Bacanu

Schizophr Res 2013 Jan 20;143(1):223-4. Epub 2012 Nov 20.

View Article and Find Full Text PDF
January 2013

Experimental validation of candidate schizophrenia gene ZNF804A as target for hsa-miR-137.

Authors:
Albert H Kim Erin K Parker Vernell Williamson Gowon O McMichael Ayman H Fanous Vladimir I Vladimirov

Schizophr Res 2012 Oct 9;141(1):60-64. Epub 2012 Aug 9.

Virginia Institute for Psychiatric and Behavioral Genetics, Department of Psychiatry, Medical College of Virginia of Virginia Commonwealth University, Richmond, VA, USA.

View Article and Find Full Text PDF
October 2012

Network-assisted investigation of combined causal signals from genome-wide association studies in schizophrenia.

Authors:
Peilin Jia Lily Wang Ayman H Fanous Carlos N Pato Todd L Edwards Zhongming Zhao

PLoS Comput Biol 2012 5;8(7):e1002587. Epub 2012 Jul 5.

Department of Biomedical Informatics, Vanderbilt University School of Medicine, Nashville, Tennessee, United States of America.

View Article and Find Full Text PDF
January 2013

Genetic overlap of schizophrenia and bipolar disorder in a high-density linkage survey in the Portuguese Island population.

Authors:
Ayman H Fanous Frank A Middleton Karen Gentile Richard L Amdur Brion S Maher Zhongming Zhao Jingchun Sun Helena Medeiros Celia Carvalho Susana R Ferreira Antonio Macedo James A Knowles Maria H Azevedo Michele T Pato Carlos N Pato

Am J Med Genet B Neuropsychiatr Genet 2012 Jun 27;159B(4):383-91. Epub 2012 Mar 27.

Mental Health Service Line, Washington VA Medical Center, Washington, DC, USA.

View Article and Find Full Text PDF
June 2012

Comprehensive gene-based association study of a chromosome 20 linked region implicates novel risk loci for depressive symptoms in psychotic illness.

Authors:
T Bernard Bigdeli Brion S Maher Zhongming Zhao Edwin J C G van den Oord Dawn L Thiselton Jingchun Sun Bradley T Webb Richard L Amdur Brandon Wormley Francis A O'Neill Dermot Walsh Brien P Riley Kenneth S Kendler Ayman H Fanous

PLoS One 2011 29;6(12):e21440. Epub 2011 Dec 29.

Department of Human and Molecular Genetics, Virginia Commonwealth University, Richmond, Virginia, United States of America.

View Article and Find Full Text PDF
April 2012

A bias-reducing pathway enrichment analysis of genome-wide association data confirmed association of the MHC region with schizophrenia.

Authors:
Peilin Jia Lily Wang Ayman H Fanous Xiangning Chen Kenneth S Kendler Zhongming Zhao

J Med Genet 2012 Feb 20;49(2):96-103. Epub 2011 Dec 20.

Department of Biomedical Informatics, Vanderbilt University School of Medicine, Nashville, TN 37203, USA.

View Article and Find Full Text PDF
February 2012

Two non-synonymous markers in PTPN21, identified by genome-wide association study data-mining and replication, are associated with schizophrenia.

Authors:
Jingchun Chen Grace Lee Ayman H Fanous Zhongming Zhao Peilin Jia Anthony O'Neill Dermot Walsh Kenneth S Kendler Xiangning Chen

Schizophr Res 2011 Sep 14;131(1-3):43-51. Epub 2011 Jul 14.

Virginia Institute for Psychiatric and Behavioral Genetics, Virginia Commonwealth University, Suite 390, 800 E. Leigh Street, Richmond, VA 23298, USA.

View Article and Find Full Text PDF
September 2011

Concordance between chart review and structured interview assessments of schizophrenic symptoms.

Authors:
Ayman H Fanous Richard L Amdur Francis A O'Neill Dermot Walsh Kenneth S Kendler

Compr Psychiatry 2012 Apr 12;53(3):275-9. Epub 2011 Jun 12.

Washington VA Medical Center, Washington, DC 20422, USA.

View Article and Find Full Text PDF
April 2012

Copy number variants in schizophrenia: confirmation of five previous findings and new evidence for 3q29 microdeletions and VIPR2 duplications.

Authors:
Douglas F Levinson Jubao Duan Sang Oh Kai Wang Alan R Sanders Jianxin Shi Nancy Zhang Bryan J Mowry Ann Olincy Farooq Amin C Robert Cloninger Jeremy M Silverman Nancy G Buccola William F Byerley Donald W Black Kenneth S Kendler Robert Freedman Frank Dudbridge Itsik Pe'er Hakon Hakonarson Sarah E Bergen Ayman H Fanous Peter A Holmans Pablo V Gejman

Am J Psychiatry 2011 Mar 1;168(3):302-16. Epub 2011 Feb 1.

Department of Psychiatry and Behavioral Sciences, Stanford University, Palo Alto, CA 94304-5797, USA.

View Article and Find Full Text PDF
March 2011

Application of systems biology approach identifies and validates GRB2 as a risk gene for schizophrenia in the Irish Case Control Study of Schizophrenia (ICCSS) sample.

Authors:
Jingchun Sun Chunling Wan Peilin Jia Ayman H Fanous Kenneth S Kendler Brien P Riley Zhongming Zhao

Schizophr Res 2011 Feb 30;125(2-3):201-8. Epub 2010 Dec 30.

Department of Biomedical Informatics, Vanderbilt University School of Medicine, Nashville, TN 37232, USA.

View Article and Find Full Text PDF
February 2011

Schizophrenia gene networks and pathways and their applications for novel candidate gene selection.

Authors:
Jingchun Sun Peilin Jia Ayman H Fanous Edwin van den Oord Xiangning Chen Brien P Riley Richard L Amdur Kenneth S Kendler Zhongming Zhao

PLoS One 2010 Jun 29;5(6):e11351. Epub 2010 Jun 29.

Department of Biomedical Informatics, Vanderbilt University School of Medicine, Nashville, Tennessee, United States of America.

View Article and Find Full Text PDF
June 2010

Detection of susceptibility genes as modifiers due to subgroup differences in complex disease.

Authors:
Sarah E Bergen Brion S Maher Ayman H Fanous Kenneth S Kendler

Eur J Hum Genet 2010 Aug 31;18(8):960-4. Epub 2010 Mar 31.

Department of Human and Molecular Genetics, Virginia Commonwealth University, Richmond, VA, USA.

View Article and Find Full Text PDF
August 2010

Genomewide association study of movement-related adverse antipsychotic effects.

Authors:
Karolina Aberg Daniel E Adkins József Bukszár Bradley T Webb Stanley N Caroff Del D Miller Jonathan Sebat Scott Stroup Ayman H Fanous Vladimir I Vladimirov Joseph L McClay Jeffrey A Lieberman Patrick F Sullivan Edwin J C G van den Oord

Biol Psychiatry 2010 Feb 28;67(3):279-82. Epub 2009 Oct 28.

Center for Biomarker Research and Personalized Medicine, School of Pharmacy, Medical College of Virginia of Virginia Commonwealth University, Richmond, Virginia 23298, USA.

View Article and Find Full Text PDF
February 2010

The dystrobrevin binding protein 1 (DTNBP1) gene is associated with schizophrenia in the Irish Case Control Study of Schizophrenia (ICCSS) sample.

Authors:
Brien Riley Po-Hsiu Kuo Brion S Maher Ayman H Fanous Jingchun Sun Brandon Wormley F Anthony O'Neill Dermot Walsh Zhongming Zhao Kenneth S Kendler

Schizophr Res 2009 Dec 2;115(2-3):245-53. Epub 2009 Oct 2.

Department of Psychiatry, Virginia Commonwealth University, Richmond, VA, USA.

View Article and Find Full Text PDF
December 2009

No association of dysbindin with symptom factors of schizophrenia in an Irish case-control sample.

Authors:
Sarah E Bergen Ayman H Fanous Po-Hsiu Kuo Brandon K Wormley F Anthony O'Neill Dermot Walsh Brien P Riley Kenneth S Kendler

Am J Med Genet B Neuropsychiatr Genet 2010 Mar;153B(2):700-705

Virginia Institute for Psychiatric and Behavioral Genetics, Virginia Commonwealth University, Richmond, Virginia.

View Article and Find Full Text PDF
March 2010

Apoptotic engulfment pathway and schizophrenia.

Authors:
Xiangning Chen Cuie Sun Qi Chen F Anthony O'Neill Dermot Walsh Ayman H Fanous Kodavali V Chowdari Vishwajit L Nimgaonkar Adrian Scott Sibylle G Schwab Dieter B Wildenauer Ronglin Che Wei Tang Yongyong Shi Lin He Xiong-Jian Luo Bing Su Todd L Edwards Zhongming Zhao Kenneth S Kendler

PLoS One 2009 Sep 1;4(9):e6875. Epub 2009 Sep 1.

Department of Psychiatry and Virginia Institute for Psychiatric and Behavior Genetics, Virginia Commonwealth University, Richmond, Virginia, USA.

View Article and Find Full Text PDF
September 2009

A multi-dimensional evidence-based candidate gene prioritization approach for complex diseases-schizophrenia as a case.

Authors:
Jingchun Sun Peilin Jia Ayman H Fanous Bradley T Webb Edwin J C G van den Oord Xiangning Chen Jozsef Bukszar Kenneth S Kendler Zhongming Zhao

Bioinformatics 2009 Oct 14;25(19):2595-6602. Epub 2009 Jul 14.

Department of Biomedical Informatics and Department of Psychiatry, Vanderbilt University, Nashville, TN 37203, USA.

View Article and Find Full Text PDF
October 2009

Polymorphisms in SLC6A4, PAH, GABRB3, and MAOB and modification of psychotic disorder features.

Authors:
Sarah E Bergen Ayman H Fanous Dermot Walsh F Anthony O'Neill Kenneth S Kendler

Schizophr Res 2009 Apr 5;109(1-3):94-7. Epub 2009 Mar 5.

Virginia Commonwealth University, Department of Human and Molecular Genetics, Richmond, Virginia 23219, USA.

View Article and Find Full Text PDF
April 2009

Polymorphisms in SLC6A4, PAH, GABRB3, and MAOB and modification of psychotic disorder features.

Authors:
Sarah E Bergen Ayman H Fanous Dermot Walsh F Anthony O'Neill Kenneth S Kendler

Schizophr Res 2009 Apr 5;109(1-3):94-7. Epub 2009 Mar 5.

Virginia Commonwealth University, Department of Human and Molecular Genetics, Richmond, Virginia 23219, USA.

View Article and Find Full Text PDF
April 2009

Genetics of clinical features and subtypes of schizophrenia: a review of the recent literature.

Authors:
Ayman H Fanous Kenneth S Kendler

Curr Psychiatry Rep 2008 Apr;10(2):164-70

Washington VA Medical Center, 50 Irving Street NW, Washington, DC 20422, USA.

View Article and Find Full Text PDF
April 2008

Novel linkage to chromosome 20p using latent classes of psychotic illness in 270 Irish high-density families.

Authors:
Ayman H Fanous Michael C Neale Bradley T Webb Richard E Straub Francis A O'Neill Dermot Walsh Brien P Riley Kenneth S Kendler

Biol Psychiatry 2008 Jul 6;64(2):121-7. Epub 2008 Feb 6.

Washington VA Medical Center, Washington, DC, USA.

View Article and Find Full Text PDF
July 2008

A longitudinal study of personality and major depression in a population-based sample of male twins.

Authors:
Ayman H Fanous Michael C Neale Steven H Aggen Kenneth S Kendler

Psychol Med 2007 Aug 4;37(8):1163-72. Epub 2007 Apr 4.

Washington VA Medical Center, Washington, DC 20422, USA.

View Article and Find Full Text PDF
August 2007

A genome-wide scan for modifier loci in schizophrenia.

Authors:
Ayman H Fanous Michael C Neale B Todd Webb Richard E Straub Richard L Amdur F Anthony O'Neill Dermot Walsh Brien P Riley Kenneth S Kendler

Am J Med Genet B Neuropsychiatr Genet 2007 Jul;144B(5):589-95

Washington VA Medical Center, Washington, DC 20422, USA.

View Article and Find Full Text PDF
July 2007

Association between the 5q31.1 gene neurogenin1 and schizophrenia.

Authors:
Ayman H Fanous Xiangning Chen Xu Wang Richard L Amdur F Anthony O'Neill Dermot Walsh Kenneth S Kendler

Am J Med Genet B Neuropsychiatr Genet 2007 Mar;144B(2):207-14

Washington VA Medical Center, Washington, District of Columbia, USA.

View Article and Find Full Text PDF
March 2007

Relationship between a high-risk haplotype in the DTNBP1 (dysbindin) gene and clinical features of schizophrenia.

Authors:
Ayman H Fanous Edwin J van den Oord Brien P Riley Steven H Aggen Michael C Neale F Anthony O'Neill Dermot Walsh Kenneth S Kendler

Am J Psychiatry 2005 Oct;162(10):1824-32

Washington VA Medical Center-Georgetown University Medical Center Schizophrenia Research Program, 50 Irving St. NW, Washington, DC 20422, USA.

View Article and Find Full Text PDF
October 2005

The genetic relationship of personality to major depression and schizophrenia.

Authors:
Ayman H Fanous Kenneth S Kendler

Neurotox Res 2004 ;6(1):43-50

Washington VA Medical Center-Georgetown University Medical Center Schizophrenia Research Program, 50 Irving St. NW, Washington, DC 20422, USA.

View Article and Find Full Text PDF
August 2004

Clinical features of psychotic disorders and polymorphisms in HT2A, DRD2, DRD4, SLC6A3 (DAT1), and BDNF: a family based association study.

Authors:
Ayman H Fanous M C Neale R E Straub B T Webb A F O'Neill D Walsh K S Kendler

Am J Med Genet B Neuropsychiatr Genet 2004 Feb;125B(1):69-78

Department of Psychiatry, Virginia Commonwealth University, Richmond, Virginia, USA.

View Article and Find Full Text PDF
February 2004