Publications by authors named "Aylwin Ng"

51Publications

Murine Norovirus Infection Induces T1 Inflammatory Responses to Dietary Antigens.

Cell Host Microbe 2018 11 1;24(5):677-688.e5. Epub 2018 Nov 1.

Department of Medicine, University of Chicago, Chicago, IL, USA; Committee on Immunology, University of Chicago, Chicago, IL, USA; Department of Pathology, University of Chicago, Chicago, IL, USA; Section of Gastroenterology, Hepatology, and Nutrition, Department of Pediatrics, University of Chicago, Chicago, IL, USA. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S19313128183054
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http://dx.doi.org/10.1016/j.chom.2018.10.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6326098PMC
November 2018

Nitric Oxide Engages an Anti-inflammatory Feedback Loop Mediated by Peroxiredoxin 5 in Phagocytes.

Cell Rep 2018 07;24(4):838-850

Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA; Department of Molecular Biology, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA; Gastrointestinal Unit and Center for the Study of Inflammatory Bowel Disease, Massachusetts General Hospital, Boston, MA 02114, USA; Harvard Medical School, Boston, MA 02114, USA; Center for Microbiome Informatics and Therapeutics, Massachusetts Institute of Technology, Cambridge, MA 02139, USA; Center for Computational and Integrative Biology, Massachusetts General Hospital, Boston, MA 02114, USA. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2018.06.081DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6156773PMC
July 2018

TMEM258 Is a Component of the Oligosaccharyltransferase Complex Controlling ER Stress and Intestinal Inflammation.

Cell Rep 2016 12;17(11):2955-2965

Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA; Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA; Gastrointestinal Unit and Center for the Study of Inflammatory Bowel Disease, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA; Center for Computational and Integrative Biology, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA; Center for Microbiome Informatics and Therapeutics, Massachusetts Institute of Technology, Cambridge, MA 02139, USA. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2016.11.042DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5661940PMC
December 2016

Profiling DNA damage-induced phosphorylation in budding yeast reveals diverse signaling networks.

Proc Natl Acad Sci U S A 2016 06 13;113(26):E3667-75. Epub 2016 Jun 13.

Division of Genetics, Department of Genetics, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115; Howard Hughes Medical Institute, Harvard Medical School, Boston, MA 02115

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http://dx.doi.org/10.1073/pnas.1602827113DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4932963PMC
June 2016

Ubiquitin Ligase TRIM62 Regulates CARD9-Mediated Anti-fungal Immunity and Intestinal Inflammation.

Immunity 2015 Oct;43(4):715-26

Gastrointestinal Unit and Center for the Study of Inflammatory Bowel Disease, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA; Center for Computational and Integrative Biology, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA; Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA. Electronic address:

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http://www.cell.com/immunity/pdf/S1074-7613(15)00405-7.pdf
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http://www.cell.com/cms/attachment/2038955196/2052729543/mmc
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http://linkinghub.elsevier.com/retrieve/pii/S107476131500405
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http://dx.doi.org/10.1016/j.immuni.2015.10.005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4672733PMC
October 2015

Integrated Genomics of Crohn's Disease Risk Variant Identifies a Role for CLEC12A in Antibacterial Autophagy.

Cell Rep 2015 Jun 18;11(12):1905-18. Epub 2015 Jun 18.

Gastrointestinal Unit and Center for the Study of Inflammatory Bowel Disease, Massachusetts General Hospital, Boston, MA 02114, USA; Center for Computational and Integrative Biology, Massachusetts General Hospital, Boston, MA 02114, USA; The Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2015.05.045DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4507440PMC
June 2015

Comprehensive identification of host modulators of HIV-1 replication using multiple orthologous RNAi reagents.

Cell Rep 2014 Oct 16;9(2):752-66. Epub 2014 Oct 16.

Microbiology and Physiological Systems (MaPS) Department, University of Massachusetts Medical School, Worcester, MA 01655, USA; Ragon Institute of Massachusetts General Hospital, MIT and Harvard University, Charlestown, MA 02129, USA. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2014.09.031DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4926641PMC
October 2014

Autophagy controls BCG-induced trained immunity and the response to intravesical BCG therapy for bladder cancer.

PLoS Pathog 2014 Oct 30;10(10):e1004485. Epub 2014 Oct 30.

Department of Internal Medicine, Radboud University Medical Center, Nijmegen, The Netherlands; Radboud Institute of Molecular Life Sciences (RIMLS), Radboud University Medical Center, Nijmegen, The Netherlands.

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http://dx.doi.org/10.1371/journal.ppat.1004485DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4214925PMC
October 2014

Systems genetics: From GWAS to disease pathways.

Biochim Biophys Acta 2014 Oct 2;1842(10):1903-1909. Epub 2014 May 2.

University of Groningen, University Medical Centre Groningen, Department of Genetics, The Netherlands. Electronic address:

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http://dx.doi.org/10.1016/j.bbadis.2014.04.025DOI Listing
October 2014

Autophagy is essential for cardiac morphogenesis during vertebrate development.

Autophagy 2014 Apr 14;10(4):572-87. Epub 2014 Jan 14.

Department of Internal Medicine; University of Texas Southwestern Medical Center; Dallas, TX USA; Department of Molecular Biology; University of Texas Southwestern Medical Center; Dallas, TX USA; Department of Pediatrics; University of Texas Southwestern Medical Center; Dallas, TX USA.

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http://dx.doi.org/10.4161/auto.27649DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4091146PMC
April 2014

Caspase 8 inhibits programmed necrosis by processing CYLD.

Nat Cell Biol 2011 Oct 30;13(12):1437-42. Epub 2011 Oct 30.

Immunology Institute, Mount Sinai School of Medicine, New York, New York 10029, USA.

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http://dx.doi.org/10.1038/ncb2362DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3229661PMC
October 2011

Leucine-rich repeat (LRR) proteins: integrators of pattern recognition and signaling in immunity.

Autophagy 2011 Sep 1;7(9):1082-4. Epub 2011 Sep 1.

Center for Computational and Integrative Biology, and Gastrointestinal Unit, Massachusetts General Hospital, Harvard Medical School, and Broad Institute of MIT and Harvard, Cambridge, MA, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3901792PMC
http://dx.doi.org/10.4161/auto.7.9.16464DOI Listing
September 2011

Meta-analysis identifies 29 additional ulcerative colitis risk loci, increasing the number of confirmed associations to 47.

Authors:
Carl A Anderson Gabrielle Boucher Charlie W Lees Andre Franke Mauro D'Amato Kent D Taylor James C Lee Philippe Goyette Marcin Imielinski Anna Latiano Caroline Lagacé Regan Scott Leila Amininejad Suzannah Bumpstead Leonard Baidoo Robert N Baldassano Murray Barclay Theodore M Bayless Stephan Brand Carsten Büning Jean-Frédéric Colombel Lee A Denson Martine De Vos Marla Dubinsky Cathryn Edwards David Ellinghaus Rudolf S N Fehrmann James A B Floyd Timothy Florin Denis Franchimont Lude Franke Michel Georges Jürgen Glas Nicole L Glazer Stephen L Guthery Talin Haritunians Nicholas K Hayward Jean-Pierre Hugot Gilles Jobin Debby Laukens Ian Lawrance Marc Lémann Arie Levine Cecile Libioulle Edouard Louis Dermot P McGovern Monica Milla Grant W Montgomery Katherine I Morley Craig Mowat Aylwin Ng William Newman Roel A Ophoff Laura Papi Orazio Palmieri Laurent Peyrin-Biroulet Julián Panés Anne Phillips Natalie J Prescott Deborah D Proctor Rebecca Roberts Richard Russell Paul Rutgeerts Jeremy Sanderson Miquel Sans Philip Schumm Frank Seibold Yashoda Sharma Lisa A Simms Mark Seielstad A Hillary Steinhart Stephan R Targan Leonard H van den Berg Morten Vatn Hein Verspaget Thomas Walters Cisca Wijmenga David C Wilson Harm-Jan Westra Ramnik J Xavier Zhen Z Zhao Cyriel Y Ponsioen Vibeke Andersen Leif Torkvist Maria Gazouli Nicholas P Anagnou Tom H Karlsen Limas Kupcinskas Jurgita Sventoraityte John C Mansfield Subra Kugathasan Mark S Silverberg Jonas Halfvarson Jerome I Rotter Christopher G Mathew Anne M Griffiths Richard Gearry Tariq Ahmad Steven R Brant Mathias Chamaillard Jack Satsangi Judy H Cho Stefan Schreiber Mark J Daly Jeffrey C Barrett Miles Parkes Vito Annese Hakon Hakonarson Graham Radford-Smith Richard H Duerr Séverine Vermeire Rinse K Weersma John D Rioux

Nat Genet 2011 Mar 6;43(3):246-52. Epub 2011 Feb 6.

Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge, UK.

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http://dx.doi.org/10.1038/ng.764DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3084597PMC
March 2011

Integrative systems biology and networks in autophagy.

Authors:
Aylwin C Y Ng

Semin Immunopathol 2010 Dec 15;32(4):355-61. Epub 2010 Sep 15.

Center for Computational and Integrative Biology and Gastrointestinal Unit, Massachusetts General Hospital, Harvard Medical School, Simches Research Center 7th Floor, 185 Cambridge Street, Boston, MA 02114, USA.

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http://dx.doi.org/10.1007/s00281-010-0225-9DOI Listing
December 2010

Wnt signaling regulates mitochondrial physiology and insulin sensitivity.

Genes Dev 2010 Jul;24(14):1507-18

Howard Hughes Medical Institute, Division of Genetics, Brigham and Women's Hospital, Department of Genetics, Harvard Medical School, Boston, Massachusetts 02115, USA.

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http://dx.doi.org/10.1101/gad.1924910DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2904941PMC
July 2010

Human leucine-rich repeat proteins: a genome-wide bioinformatic categorization and functional analysis in innate immunity.

Proc Natl Acad Sci U S A 2011 Mar 29;108 Suppl 1:4631-8. Epub 2010 Jun 29.

Center for Computational and Integrative Biology, and Gastrointestinal Unit, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA.

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http://dx.doi.org/10.1073/pnas.1000093107DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3063585PMC
March 2011

A genome-wide genetic screen for host factors required for hepatitis C virus propagation.

Proc Natl Acad Sci U S A 2009 Sep 27;106(38):16410-5. Epub 2009 Aug 27.

Liver Diseases Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD 20892, USA.

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http://dx.doi.org/10.1073/pnas.0907439106DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2752535PMC
September 2009

A novel hybrid yeast-human network analysis reveals an essential role for FNBP1L in antibacterial autophagy.

J Immunol 2009 Apr;182(8):4917-30

Center for Computational and Integrative Biology, MassachusettsGeneral Hospital, Harvard Medical School, Boston, MA 02114, USA.

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http://dx.doi.org/10.4049/jimmunol.0803050DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2752416PMC
April 2009

Role for beta-catenin and HOX transcription factors in Caenorhabditis elegans and mammalian host epithelial-pathogen interactions.

Proc Natl Acad Sci U S A 2008 Nov 3;105(45):17469-74. Epub 2008 Nov 3.

Department of Genetics, Harvard Medical School, and Center for Computational and Integrative Biology, Massachusetts General Hospital, Boston, MA 02114, USA.

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http://dx.doi.org/10.1073/pnas.0809527105DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2582251PMC
November 2008

Hoxc6 is overexpressed in gastrointestinal carcinoids and interacts with JunD to regulate tumor growth.

Gastroenterology 2008 Sep 23;135(3):907-16, 916.e1-2. Epub 2008 Jul 23.

Gastrointestinal Unit, Massachusetts General Hospital, Boston, Massachusetts 02114, USA.

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http://dx.doi.org/10.1053/j.gastro.2008.06.034DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3777410PMC
September 2008

Defining molecular classifications and targets in gastroenteropancreatic neuroendocrine tumors through DNA microarray analysis.

Endocr Relat Cancer 2008 Mar;15(1):243-56

Gastrointestinal Unit, Department of Medicine, Cancer Center, Center for Computational and Integrative Biology, Massachusetts General Hospital, Boston, MA 02114, USA.

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http://dx.doi.org/10.1677/ERC-07-0194DOI Listing
March 2008

Resources for integrative systems biology: from data through databases to networks and dynamic system models.

Brief Bioinform 2006 Dec 13;7(4):318-30. Epub 2006 Oct 13.

Bioinformatics and Systems Biology Group, Ludwig Institute for Cancer Research, University College London Branch, 91 Riding House Street, London W1W 7BS, UK.

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http://dx.doi.org/10.1093/bib/bbl036DOI Listing
December 2006

pSTIING: a 'systems' approach towards integrating signalling pathways, interaction and transcriptional regulatory networks in inflammation and cancer.

Nucleic Acids Res 2006 Jan;34(Database issue):D527-34

Bioinformatics and Systems Biology Group, Ludwig Institute for Cancer Research, UCL Branch London, W1W 7BS, UK.

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http://dx.doi.org/10.1093/nar/gkj044DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1347407PMC
January 2006

Regulation of the H19 imprinting gene expression in human nasopharyngeal carcinoma by methylation.

Int J Cancer 2003 Mar;104(2):179-87

Laboratory of Gene Structure and Expression, Division of Cellular and Molecular Research, National Cancer Centre, Singapore.

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http://doi.wiley.com/10.1002/ijc.10926
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http://dx.doi.org/10.1002/ijc.10926DOI Listing
March 2003

The vaccinia virus A41L protein is a soluble 30 kDa glycoprotein that affects virus virulence.

J Gen Virol 2001 Sep;82(Pt 9):2095-2105

Sir William Dunn School of Pathology, University of Oxford, South Parks Road, Oxford OX1 3RE, UK1.

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http://dx.doi.org/10.1099/0022-1317-82-9-2095DOI Listing
September 2001