Aykut Uren

Aykut Uren

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Aykut Uren

Publications by authors named "Aykut Uren"

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Covalent Complex of DNA and Bacterial Topoisomerase: Implications in Antibacterial Drug Development.

ChemMedChem 2020 Apr 18;15(7):623-631. Epub 2020 Mar 18.

Biomolecular sciences institute, Florida International University, Miami, FL 33199, USA.

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http://dx.doi.org/10.1002/cmdc.201900721DOI Listing
April 2020

Development of an Ewing sarcoma cell line with resistance to EWS‑FLI1 inhibitor YK‑4‑279.

Mol Med Rep 2020 Mar 16;21(3):1667-1675. Epub 2020 Jan 16.

Department of Oncology, Georgetown University Medical Center, Georgetown University, Washington, DC 20057, USA.

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http://dx.doi.org/10.3892/mmr.2020.10948DOI Listing
March 2020

Small Molecule Binds with Lymphocyte Antigen 6K to Induce Cancer Cell Death.

Cancers (Basel) 2020 02 22;12(2). Epub 2020 Feb 22.

Department of Oncology, Georgetown University Medical Center, Washington, DC 20057, USA.

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http://dx.doi.org/10.3390/cancers12020509DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7072568PMC
February 2020

Pilots' Healthcare Seeking Anxiety When Experiencing Chest Pain.

J Occup Environ Med 2019 Sep;61(9):e401-e405

Georgetown University School of Medicine, Washington, DC Georgetown University Medical Center, Washington, DC.

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http://dx.doi.org/10.1097/JOM.0000000000001662DOI Listing
September 2019

Identification of undecylenic acid as EAG channel inhibitor using surface plasmon resonance-based screen of KCNH channels.

BMC Pharmacol Toxicol 2019 07 17;20(1):42. Epub 2019 Jul 17.

Department of Pharmacology and Physiology, Georgetown University Medical Center, Washington, DC, USA.

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http://dx.doi.org/10.1186/s40360-019-0324-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6637479PMC
July 2019

Helix-A peptide prevents gp120-mediated neuronal loss.

Mol Brain 2019 06 25;12(1):61. Epub 2019 Jun 25.

Department of Neuroscience, Laboratory of Preclinical Neurobiology, Georgetown University, EP09, New Research Building, 3970 Reservoir Rd., NW, Washington, DC, 20057, USA.

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http://dx.doi.org/10.1186/s13041-019-0482-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6593494PMC
June 2019

Ezrin Promotes Stem Cell Properties in Pancreatic Ductal Adenocarcinoma.

Mol Cancer Res 2019 04 17;17(4):929-936. Epub 2019 Jan 17.

Department of Oncology, Sydney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, Maryland.

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http://mcr.aacrjournals.org/lookup/doi/10.1158/1541-7786.MCR
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http://dx.doi.org/10.1158/1541-7786.MCR-18-0367DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6445733PMC
April 2019

Investigating molecular interactions between oxidized neuroglobin and cytochrome c.

Sci Rep 2018 Jul 12;8(1):10557. Epub 2018 Jul 12.

Department of Oncology, Georgetown University, Washington D.C., USA.

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http://dx.doi.org/10.1038/s41598-018-28836-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6043506PMC
July 2018

Investigating cyclic nucleotide and cyclic dinucleotide binding to HCN channels by surface plasmon resonance.

PLoS One 2017 26;12(9):e0185359. Epub 2017 Sep 26.

Department of Pharmacology and Physiology, Georgetown University Medical Center, Washington, DC, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0185359PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5614581PMC
October 2017

An N,N-Bis(benzimidazolylpicolinoyl)piperazine (BT-11): A Novel Lanthionine Synthetase C-Like 2-Based Therapeutic for Inflammatory Bowel Disease.

J Med Chem 2016 11 15;59(22):10113-10126. Epub 2016 Nov 15.

Biotherapeutics Inc. , 1800 Kraft Drive, Suite 200, Blacksburg, Virginia 24060, United States.

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http://dx.doi.org/10.1021/acs.jmedchem.6b00412DOI Listing
November 2016

Interaction Between HIV-1 Nef and Calnexin: From Modeling to Small Molecule Inhibitors Reversing HIV-Induced Lipid Accumulation.

Arterioscler Thromb Vasc Biol 2016 09 28;36(9):1758-71. Epub 2016 Jul 28.

From the George Washington University School of Medicine and Health Sciences, Washington, DC (R.H., L.D., T.P., B.B., A.A.A., M.B.); University of Alabama School of Medicine and Dentistry, Birmingham, (M.V., D.V.); Baker IDI Heart and Diabetes Institute, Melbourne, Victoria, Australia (D.S.); Engelhardt Institute of Molecular Biology RAS, Moscow, Russia (A.A. Anashkina, A.A. Adzhubei); and Georgetown University Medical Center, Lombardi Comprehensive Cancer Center, Washington, DC (A.Ü).

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http://dx.doi.org/10.1161/ATVBAHA.116.307997DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5040351PMC
September 2016

Modeling-Enabled Characterization of Novel NLRX1 Ligands.

PLoS One 2015 29;10(12):e0145420. Epub 2015 Dec 29.

The Center for Modeling Immunity to Enteric Pathogens, Virginia Bioinformatics Institute, Virginia Tech, Blacksburg, Virginia, 24061, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0145420PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4694766PMC
July 2016

Identification of a binding site of the human immunodeficiency virus envelope protein gp120 to neuronal-specific tubulin.

J Neurochem 2016 Apr 15;137(2):287-98. Epub 2016 Mar 15.

Laboratory of Preclinical Neurobiology, Department of Neuroscience, Georgetown University Medical Center, Washington, District of Columbia, USA.

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http://dx.doi.org/10.1111/jnc.13557DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4828312PMC
April 2016

Human papillomavirus type 16 E7 oncoprotein upregulates the retinoic acid receptor-beta expression in cervical cancer cell lines and K14E7 transgenic mice.

Mol Cell Biochem 2015 Oct 15;408(1-2):261-72. Epub 2015 Jul 15.

Departamento de Genética y Biología Molecular, Centro de Investigación y de Estudios Avanzados del Instituto Politécnico Nacional (CINVESTAV-IPN), Av. IPN 2508, San Pedro Zacatenco, Gustavo A. Madero, 07360, Ciudad de México, México.

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http://dx.doi.org/10.1007/s11010-015-2504-1DOI Listing
October 2015

Note: Model identification and analysis of bivalent analyte surface plasmon resonance data.

Rev Sci Instrum 2015 Oct;86(10):106107

Department of Physics, Florida International University, Miami, Florida 33199, USA.

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http://dx.doi.org/10.1063/1.4933318DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4617740PMC
October 2015

Inorganic polyphosphates are important for cell survival and motility of human skin keratinocytes.

Exp Dermatol 2015 Aug 8;24(8):636-9. Epub 2015 May 8.

Department of Biochemistry and Molecular Biology, Georgetown University, School of Medicine, Washington, DC, USA.

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http://dx.doi.org/10.1111/exd.12729DOI Listing
August 2015

Generation of K14-E7/∆N87βcat double transgenic mice as a model of cervical cancer.

Methods Mol Biol 2015 ;1249:393-406

Department of Genetics and Bioinformatics, Faculty of Arts and Sciences, Bahcesehir University, Istanbul, Turkey.

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http://link.springer.com/10.1007/978-1-4939-2013-6_29
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http://dx.doi.org/10.1007/978-1-4939-2013-6_29DOI Listing
June 2015

RNA helicase A activity is inhibited by oncogenic transcription factor EWS-FLI1.

Nucleic Acids Res 2015 Jan 6;43(2):1069-80. Epub 2015 Jan 6.

Department of Oncology, Lombardi Comprehensive Cancer Center, Georgetown University, 3970 Reservoir Road NW, New Research Building E316, Washington, DC 20007, USA.

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http://dx.doi.org/10.1093/nar/gku1328DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4333382PMC
January 2015

Synthesis and structure-activity relationship studies of small molecule disruptors of EWS-FLI1 interactions in Ewing's sarcoma.

J Med Chem 2014 Dec 12;57(24):10290-303. Epub 2014 Dec 12.

Center for Drug Discovery, Georgetown University Medical Center , New Research Building EP07, 3970 Reservoir Road, NW, Washington, D.C. 20057, United States.

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http://dx.doi.org/10.1021/jm501372pDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4281097PMC
December 2014

Loss of SS18-SSX1 inhibits viability and induces apoptosis in synovial sarcoma.

Clin Orthop Relat Res 2014 Mar;472(3):874-82

MedStar Georgetown Orthopaedic Institute, 110 Irving Street, NW C-2173, Washington, DC, 20010, USA,

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http://dx.doi.org/10.1007/s11999-013-3065-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3916608PMC
March 2014

Secreted Frizzled-related protein potentiation versus inhibition of Wnt3a/β-catenin signaling.

Cell Signal 2014 Jan 28;26(1):94-101. Epub 2013 Sep 28.

Laboratory of Cellular and Molecular Biology, National Cancer Institute, Bethesda, MD 20892, United States.

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http://dx.doi.org/10.1016/j.cellsig.2013.09.016DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3953133PMC
January 2014

Design, synthesis and biological evaluation of ezrin inhibitors targeting metastatic osteosarcoma.

Bioorg Med Chem 2014 Jan 14;22(1):478-87. Epub 2013 Nov 14.

Georgetown University Medical Center, Lombardi Comprehensive Cancer Center, 3970 Reservoir Road, NW, The Research Building, Washington, DC 20057, USA. Electronic address:

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http://dx.doi.org/10.1016/j.bmc.2013.11.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4349528PMC
January 2014

Gene expression profile regulated by the HPV16 E7 oncoprotein and estradiol in cervical tissue.

Virology 2013 Dec 27;447(1-2):155-65. Epub 2013 Sep 27.

Department of Genetics and Molecular Biology, Centro de Investigación y de Estudios Avanzados (Cinvestav), Mexico City 07360, Mexico; Research Unit, Hospital Juárez de México, Mexico City 07760, Mexico. Electronic address:

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http://dx.doi.org/10.1016/j.virol.2013.08.036DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3982872PMC
December 2013

Emergence of ETS transcription factors as diagnostic tools and therapeutic targets in prostate cancer.

Am J Transl Res 2013 19;5(3):254-68. Epub 2013 Apr 19.

Lombardi Comprehensive Cancer Center, Georgetown University Washington DC.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3633969PMC
May 2013

Valosin containing protein (VCP/p97) is a novel substrate for the protein tyrosine phosphatase PTPL1.

Exp Cell Res 2013 Jan 24;319(1):1-11. Epub 2012 Sep 24.

Departments of Oncology and Pediatrics, Lombardi Comprehensive Cancer Center, Georgetown University, Washington, DC 20057, USA.

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http://dx.doi.org/10.1016/j.yexcr.2012.09.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3638858PMC
January 2013

A new era for an ancient drug: arsenic trioxide and Hedgehog signaling.

Vitam Horm 2012 ;88:333-54

Lombardi Comprehensive Cancer Center, Georgetown University Medical Center, Washington, District of Columbia, USA.

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http://dx.doi.org/10.1016/B978-0-12-394622-5.00015-8DOI Listing
August 2012

Predicting new indications for approved drugs using a proteochemometric method.

J Med Chem 2012 Aug 25;55(15):6832-48. Epub 2012 Jul 25.

Department of Oncology, Lombardi Comprehensive Cancer Center, Georgetown University Medical Center , Washington, DC 20057, United States.

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http://dx.doi.org/10.1021/jm300576qDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3419493PMC
August 2012

The ezrin metastatic phenotype is associated with the initiation of protein translation.

Neoplasia 2012 Apr;14(4):297-310

Tumor and Metastasis Biology Section, Pediatric Oncology Branch, Center for Cancer Research, National Cancer Institute, Bethesda, MD 20892, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3349256PMC
http://dx.doi.org/10.1593/neo.11518DOI Listing
April 2012

A comparative study of recombinant mouse and human apurinic/apyrimidinic endonuclease.

Mol Cell Biochem 2012 Mar 1;362(1-2):195-201. Epub 2011 Nov 1.

Department of Oncology, Lombardi Comprehensive Cancer Center, Georgetown University Medical Center, Washington, DC 20057, USA.

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http://dx.doi.org/10.1007/s11010-011-1142-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3493166PMC
March 2012

Characterization of magnesium requirement of human 5'-tyrosyl DNA phosphodiesterase mediated reaction.

BMC Res Notes 2012 Mar 9;5:134. Epub 2012 Mar 9.

Department of Oncology, Lombardi Comprehensive Cancer Center, Georgetown University Medical Center, Washington, DC 20057, USA.

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http://dx.doi.org/10.1186/1756-0500-5-134DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3315744PMC
March 2012

The E6 oncoprotein from HPV16 enhances the canonical Wnt/β-catenin pathway in skin epidermis in vivo.

Mol Cancer Res 2012 Feb 7;10(2):250-8. Epub 2011 Dec 7.

Deptamento de Genética y Biología Molecular, Centro de Investigación y de Estudios Avanzados (Cinvestav), México, México.

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http://dx.doi.org/10.1158/1541-7786.MCR-11-0287DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3332097PMC
February 2012

Development of a novel assay for human tyrosyl DNA phosphodiesterase 2.

Anal Biochem 2011 Sep 12;416(1):112-6. Epub 2011 May 12.

Department of Oncology, Lombardi Comprehensive Cancer Center, Georgetown University Medical Center, Washington, DC 20057, USA.

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http://dx.doi.org/10.1016/j.ab.2011.05.008DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3125436PMC
September 2011

A real-time electrical impedance based technique to measure invasion of endothelial cell monolayer by cancer cells.

J Vis Exp 2011 Apr 1(50). Epub 2011 Apr 1.

Lombardi Comprehensive Cancer Center, Georgetown University.

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http://www.jove.com/index/Details.stp?ID=2792
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http://dx.doi.org/10.3791/2792DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3169283PMC
April 2011

YK-4-279 inhibits ERG and ETV1 mediated prostate cancer cell invasion.

PLoS One 2011 Apr 29;6(4):e19343. Epub 2011 Apr 29.

Lombardi Comprehensive Cancer Center, Georgetown University Medical Center, Washington, D. C., United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0019343PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3084826PMC
April 2011

Binding kinetics and activity of human poly(ADP-ribose) polymerase-1 on oligo-deoxyribonucleotide substrates.

J Mol Recognit 2009 Nov-Dec;22(6):446-52

Departments of Radiation Medicine, Lombardi Comprehensive Cancer Center, Georgetown University, Washington, DC 20057, USA.

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http://dx.doi.org/10.1002/jmr.962DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3493158PMC
February 2010

Excised damaged base determines the turnover of human N-methylpurine-DNA glycosylase.

DNA Repair (Amst) 2009 Oct 17;8(10):1201-6. Epub 2009 Jul 17.

Department of Oncology, Lombardi Comprehensive Cancer Center, Georgetown University Medical Center, Washington, DC 20057, United States.

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http://dx.doi.org/10.1016/j.dnarep.2009.06.005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2752946PMC
October 2009

Wnt signaling promotes proliferation and stemness regulation of spermatogonial stem/progenitor cells.

Reproduction 2009 Jul 6;138(1):151-62. Epub 2009 May 6.

Departments of, Biochemistry and Molecular and Cellular Biology Oncology, Lombardi Comprehensive Cancer Center, Georgetown University Medical Center, 3900 Reservoir Road, Northwest, Washington, District of Columbia 20057, USA.

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http://dx.doi.org/10.1530/REP-08-0510DOI Listing
July 2009

GLI1 is a direct transcriptional target of EWS-FLI1 oncoprotein.

J Biol Chem 2009 Apr 3;284(14):9074-82. Epub 2009 Feb 3.

Lombardi Comprehensive Cancer Center, Georgetown University Medical Center, Washington, D C 20057, USA.

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http://www.jbc.org/content/284/14/9074.full.pdf
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http://www.jbc.org/cgi/doi/10.1074/jbc.M806233200
Publisher Site
http://dx.doi.org/10.1074/jbc.M806233200DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2666556PMC
April 2009

A global benchmark study using affinity-based biosensors.

Authors:
Rebecca L Rich Giuseppe A Papalia Peter J Flynn Jamie Furneisen John Quinn Joshua S Klein Phini S Katsamba M Brent Waddell Michael Scott Joshua Thompson Judie Berlier Schuyler Corry Mireille Baltzinger Gabrielle Zeder-Lutz Andreas Schoenemann Anca Clabbers Sebastien Wieckowski Mary M Murphy Phillip Page Thomas E Ryan Jay Duffner Tanmoy Ganguly John Corbin Satyen Gautam Gregor Anderluh Andrej Bavdek Dana Reichmann Satya P Yadav Eric Hommema Ewa Pol Andrew Drake Scott Klakamp Trevor Chapman Dawn Kernaghan Ken Miller Jason Schuman Kevin Lindquist Kara Herlihy Michael B Murphy Richard Bohnsack Bruce Andrien Pietro Brandani Danny Terwey Rohn Millican Ryan J Darling Liann Wang Quincy Carter Joe Dotzlaf Jacinto Lopez-Sagaseta Islay Campbell Paola Torreri Sylviane Hoos Patrick England Yang Liu Yasmina Abdiche Daniel Malashock Alanna Pinkerton Melanie Wong Eileen Lafer Cynthia Hinck Kevin Thompson Carmelo Di Primo Alison Joyce Jonathan Brooks Federico Torta Anne Birgitte Bagge Hagel Janus Krarup Jesper Pass Monica Ferreira Sergei Shikov Malgorzata Mikolajczyk Yuki Abe Gaetano Barbato Anthony M Giannetti Ganeshram Krishnamoorthy Bianca Beusink Daulet Satpaev Tiffany Tsang Eric Fang James Partridge Stephen Brohawn James Horn Otto Pritsch Gonzalo Obal Sanjay Nilapwar Ben Busby Gerardo Gutierrez-Sanchez Ruchira Das Gupta Sylvie Canepa Krista Witte Zaneta Nikolovska-Coleska Yun Hee Cho Roberta D'Agata Kristian Schlick Rosy Calvert Eva M Munoz Maria Jose Hernaiz Tsafir Bravman Monica Dines Min-Hsiang Yang Agnes Puskas Erica Boni Jiejin Li Martin Wear Asya Grinberg Jason Baardsnes Olan Dolezal Melicia Gainey Henrik Anderson Jinlin Peng Mark Lewis Peter Spies Quyhn Trinh Sergei Bibikov Jill Raymond Mohammed Yousef Vidya Chandrasekaran Yuguo Feng Anne Emerick Suparna Mundodo Rejane Guimaraes Katy McGirr Yue-Ji Li Heather Hughes Hubert Mantz Rostislav Skrabana Mark Witmer Joshua Ballard Loic Martin Petr Skladal George Korza Ite Laird-Offringa Charlene S Lee Abdelkrim Khadir Frank Podlaski Phillippe Neuner Julie Rothacker Ashique Rafique Nico Dankbar Peter Kainz Erk Gedig Momchilo Vuyisich Christina Boozer Nguyen Ly Mark Toews Aykut Uren Oleksandr Kalyuzhniy Kenneth Lewis Eugene Chomey Brian J Pak David G Myszka

Anal Biochem 2009 Mar 27;386(2):194-216. Epub 2008 Nov 27.

Center for Biomolecular Interaction Analysis, School of Medicine, University of Utah, Salt Lake City, UT 84132, USA.

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http://dx.doi.org/10.1016/j.ab.2008.11.021DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3793259PMC
March 2009

Wnt10b induces chemotaxis of osteosarcoma and correlates with reduced survival.

Pediatr Blood Cancer 2008 Sep;51(3):349-55

Georgetown University School of Medicine, Washington, District of Columbia, USA.

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http://dx.doi.org/10.1002/pbc.21595DOI Listing
September 2008

Expression, purification and characterization of codon-optimized human N-methylpurine-DNA glycosylase from Escherichia coli.

Protein Expr Purif 2008 Apr 10;58(2):257-62. Epub 2007 Dec 10.

Department of Oncology, Lombardi Comprehensive Cancer Center, Georgetown University Medical Center, LL level, S-122, 3800 Reservoir Road, NW, Washington, DC 20057, USA.

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http://dx.doi.org/10.1016/j.pep.2007.12.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2702510PMC
April 2008

Wnt-3a and Dickkopf-1 stimulate neurite outgrowth in Ewing tumor cells via a Frizzled3- and c-Jun N-terminal kinase-dependent mechanism.

Mol Cell Biol 2008 Apr 22;28(7):2368-79. Epub 2008 Jan 22.

National Cancer Institute, Bldg. 37, Room 2042, 37 Convent Drive, MSC 4256, Bethesda, MD 20892-4256, USA.

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http://dx.doi.org/10.1128/MCB.01780-07DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2268413PMC
April 2008

Dipole-dipole interaction stabilizes the transition state of apurinic/apyrimidinic endonuclease--abasic site interaction.

J Biol Chem 2008 Jan 19;283(3):1334-9. Epub 2007 Nov 19.

Department of Oncology, Lombardi Comprehensive Cancer Center, Georgetown University Medical Center, 3800 Reservoir Road NW, Washington, D. C. 20057, USA.

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http://www.jbc.org/lookup/doi/10.1074/jbc.M704594200
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http://dx.doi.org/10.1074/jbc.M704594200DOI Listing
January 2008

N-terminal extension of N-methylpurine DNA glycosylase is required for turnover in hypoxanthine excision reaction.

J Biol Chem 2007 Oct 22;282(41):30078-84. Epub 2007 Aug 22.

Department of Oncology, Lombardi Comprehensive Cancer Center, Georgetown University Medical Center, Washington, D. C. 20057, USA.

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http://www.jbc.org/lookup/doi/10.1074/jbc.M704051200
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http://dx.doi.org/10.1074/jbc.M704051200DOI Listing
October 2007

Oncoprotein EWS-FLI1 activity is enhanced by RNA helicase A.

Cancer Res 2006 Jun;66(11):5574-81

Lombardi Comprehensive Cancer Center, Georgetown University Medical Center, Washington, District of Columbia, USA.

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http://dx.doi.org/10.1158/0008-5472.CAN-05-3293DOI Listing
June 2006

Ewing's sarcoma oncoprotein EWS-FLI1: the perfect target without a therapeutic agent.

Future Oncol 2005 Aug;1(4):521-8

Georgetown University School of Medicine, Lombardi Comprehensive Cancer Center, 3970 Reservoir Road North West, New Research Building, Room W316, Washington DC, WA 20057, USA.

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http://dx.doi.org/10.2217/14796694.1.4.521DOI Listing
August 2005

Activation of the canonical Wnt pathway during genital keratinocyte transformation: a model for cervical cancer progression.

Cancer Res 2005 Jul;65(14):6199-206

Georgetown University Medical Center, Lombardi Comprehensive Cancer Center, Washington, District of Columbia 20057, USA.

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http://cancerres.aacrjournals.org/lookup/doi/10.1158/0008-54
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http://dx.doi.org/10.1158/0008-5472.CAN-05-0455DOI Listing
July 2005

PTPL1 is a direct transcriptional target of EWS-FLI1 and modulates Ewing's Sarcoma tumorigenesis.

Oncogene 2005 Apr;24(16):2715-22

Lombardi Comprehensive Cancer Center, Georgetown University Medical Center, Washington, DC 20057, USA.

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http://dx.doi.org/10.1038/sj.onc.1208247DOI Listing
April 2005

Pediatric malignancies provide unique cancer therapy targets.

Curr Opin Pediatr 2005 Feb;17(1):14-9

Department of Oncology, Lombardi Comprehensive Cancer Center, Georgetown University, Washington, DC, USA.

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http://dx.doi.org/10.1097/01.mop.0000147904.84978.aeDOI Listing
February 2005

Wnt-3a-dependent cell motility involves RhoA activation and is specifically regulated by dishevelled-2.

J Biol Chem 2005 Jan 27;280(1):777-86. Epub 2004 Oct 27.

Laboratories of Cellular and Molecular Biology, NCI, National Institutes of Health, Bethesda, Maryland 20892, USA.

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http://dx.doi.org/10.1074/jbc.M406391200DOI Listing
January 2005

Identification of a peptide binding motif for secreted frizzled-related protein-1.

Peptides 2004 Nov;25(11):1831-8

Laboratory of Cellular and Molecular Biology, National Cancer Institute, Bethesda, MD 20892-4256, USA.

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http://dx.doi.org/10.1016/j.peptides.2004.07.010DOI Listing
November 2004

Recombinant EWS-FLI1 oncoprotein activates transcription.

Biochemistry 2004 Oct;43(42):13579-89

Lombardi Comprehensive Cancer Center, Georgetown University Medical Center, Research Building, Room W316, 3970 Reservoir Road, N.W., Box 571469, Washington, DC 20057-1469, USA.

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http://dx.doi.org/10.1021/bi048776qDOI Listing
October 2004

Wnt/Frizzled signaling in Ewing sarcoma.

Pediatr Blood Cancer 2004 Sep;43(3):243-9

Georgetown University Medical Center, Lombardi Cancer Center, Research Building, Washington, DC 20057-1469, USA.

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http://dx.doi.org/10.1002/pbc.20124DOI Listing
September 2004

Disulfide bond assignments of secreted Frizzled-related protein-1 provide insights about Frizzled homology and netrin modules.

J Biol Chem 2002 Feb 10;277(7):5134-44. Epub 2001 Dec 10.

Wistar Institute, Philadelphia, Pennsylvania 19104, USA.

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http://www.jbc.org/lookup/doi/10.1074/jbc.M108533200
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http://dx.doi.org/10.1074/jbc.M108533200DOI Listing
February 2002