Aye Aye Thike

Delineating the breast cancer immune microenvironment in the era of multiplex immunohistochemistry/immunofluorescence (mIHC/IF).

Authors:

Tracy Zhijun Tien Justina Nadia Li Wen Lee Jeffrey Chun Tatt Lim Xiao-Yang Chen Aye Aye Thike Puay Hoon Tan Joe Poh Sheng Yeong

Histopathology 2021 Jan 5. Epub 2021 Jan 5.

Integrative Biology for Theranostics, Institute of Molecular Cell Biology, Agency of Science, Technology and Research (A*STAR), Singapore, 138673, Singapore.

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January 2021

Breast ductal Carcinoma in situ associated with microinvasion induces immunological response and predicts ipsilateral invasive recurrence.

Authors:

Xiao-Yang Chen Aye Aye Thike Valerie Cui Yun Koh Nur Diyana Md Nasir Boon Huat Bay Puay Hoon Tan

Virchows Arch 2020 Nov 2. Epub 2020 Nov 2.

Department of Anatomical Pathology, Singapore General Hospital, Singapore, Singapore.

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November 2020

Quantitative stain-free imaging and digital profiling of collagen structure reveal diverse survival of triple negative breast cancer patients.

Authors:

Laurent Gole Joe Yeong Jeffrey Chun Tatt Lim Kok Haur Ong Hao Han Aye Aye Thike Yong Cheng Poh Sidney Yee Jabed Iqbal Wanjin Hong Bernett Lee Weimiao Yu Puay Hoon Tan

Breast Cancer Res 2020 05 6;22(1):42. Epub 2020 May 6.

Division of Pathology, Singapore General Hospital, 20 College Road, Academia, Level 7, Diagnostics Tower, Singapore, 169856, Singapore.

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May 2020

Morphologic and genetic heterogeneity in breast fibroepithelial lesions-a comprehensive mapping study.

Authors:

Benjamin Yongcheng Tan Nur Diyana Md Nasir Huan Ying Chang Cedric Chuan Young Ng Peiyong Guan Sanjanaa Nagarajan Vikneswari Rajasegaran Jing Yi Lee Jing Quan Lim Aye Aye Thike Bin Tean Teh Puay Hoon Tan

Mod Pathol 2020 09 22;33(9):1732-1745. Epub 2020 Apr 22.

Department of Anatomical Pathology, Singapore General Hospital, Singapore, Singapore.

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September 2020

Counting Mitoses With Digital Pathology in Breast Phyllodes Tumors.

Authors:

Zi Long Chow Aye Aye Thike Hui Hua Li Nur Diyana Md Nasir Joe Poh Sheng Yeong Puay Hoon Tan

Arch Pathol Lab Med 2020 11;144(11):1397-1400

From the Department of Anatomical Pathology (Chow, Thike, Tan, Nasir), Singapore General Hospital, Singapore.

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November 2020

PD-L1 expression is an unfavourable prognostic indicator in Asian renal cell carcinomas.

Authors:

Joe Yeong Zitong Zhao Jeffrey Chun Tatt Lim Huihua Li Aye Aye Thike Valerie Cui Yun Koh Bin Tean Teh Ravindran Kanesvaran Chee Keong Toh Puay Hoon Tan Li Yan Khor

J Clin Pathol 2020 Aug 24;73(8):463-469. Epub 2020 Jan 24.

Anatomical Pathology, Singapore General Hospital, Singapore

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August 2020

Multiplex immunohistochemistry/immunofluorescence (mIHC/IF) for PD-L1 testing in triple-negative breast cancer: a translational assay compared with conventional IHC.

Authors:

Joe Yeong Tira Tan Zi Long Chow Qing Cheng Bernett Lee Amanda Seet Johnathan Xiande Lim Jeffrey Chun Tatt Lim Clara Chong Hui Ong Aye Aye Thike Sahil Saraf Benjamin Yong Cheng Tan Yong Cheng Poh Sidney Yee Jin Liu Elaine Lim Jabed Iqbal Rebecca Dent Puay Hoon Tan

J Clin Pathol 2020 Sep 22;73(9):557-562. Epub 2020 Jan 22.

Division of Pathology, Singapore General Hospital, Singapore

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September 2020

Higher density of stromal M2 macrophages in breast ductal carcinoma in situ predicts recurrence.

Authors:

Xiao-Yang Chen Aye Aye Thike Nur Diyana Md Nasir Valerie Cui Yun Koh Boon Huat Bay Puay Hoon Tan

Virchows Arch 2020 Jun 3;476(6):825-833. Epub 2020 Jan 3.

Department of Anatomical Pathology, Singapore General Hospital, Singapore, Singapore.

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June 2020

Higher densities of tumour-infiltrating lymphocytes and CD4 T cells predict recurrence and progression of ductal carcinoma in situ of the breast.

Authors:

Aye Aye Thike Xiaoyang Chen Valerie Cui Yun Koh Nur Diyana Binte Md Nasir Joe P S Yeong Boon Huat Bay Puay Hoon Tan

Histopathology 2020 May;76(6):852-864

Department of Anatomical Pathology, Singapore General Hospital, Singapore.

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May 2020

, and in fibroepithelial tumours of the breast.

Authors:

Huan Ying Chang Valerie Cui Yun Koh Nur Diyana Md Nasir Cedric Chuan Young Ng Peiyong Guan Aye Aye Thike Bin Tean Teh Puay Hoon Tan

J Clin Pathol 2020 Jan 29;73(1):51-56. Epub 2019 Oct 29.

Department of Anatomical Pathology, Singapore General Hospital, Singapore, Singapore

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January 2020

A novel genomic panel as an adjunctive diagnostic tool for the characterization and profiling of breast Fibroepithelial lesions.

BMC Med Genomics 2019 10 23;12(1):142. Epub 2019 Oct 23.

Department of Anatomical Pathology, Singapore General Hospital, Singapore, Singapore.

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October 2019

Characteristics, behaviour and role of biomarkers in metastatic triple-negative breast cancer.

Authors:

Yutaro Goto Aye Aye Thike Clara Chong Hui Ong Johnathan Xiande Lim Nur Diyana Md Nasir Huihua Li Valerie Cui Yun Koh Xiao-Yang Chen Joe Poh Sheng Yeong Hironobu Sasano Puay Hoon Tan

J Clin Pathol 2020 Mar 28;73(3):147-153. Epub 2019 Sep 28.

Duke-NUS Medical School, Singapore, Singapore

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March 2020

Genomic characterisation of breast fibroepithelial lesions in an international cohort.

J Pathol 2019 12 8;249(4):447-460. Epub 2019 Oct 8.

Department of Anatomical Pathology, Singapore General Hospital, Singapore.

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December 2019

Evaluation of phospho-histone H3 in Asian triple-negative breast cancer using multiplex immunofluorescence.

Authors:

Chi Peng Timothy Lai Joe Poh Sheng Yeong An Sen Tan Chong Hui Clara Ong Bernett Lee Jeffrey Chun Tatt Lim Aye Aye Thike Jabed Iqbal Rebecca Alexandra Dent Elaine Hsuen Lim Puay Hoon Tan

Breast Cancer Res Treat 2019 Nov 13;178(2):295-305. Epub 2019 Aug 13.

Division of Pathology, Singapore General Hospital, 20 College Road, Singapore, 169856, Singapore.

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November 2019

The role of Ki-67 in Asian triple negative breast cancers: a novel combinatory panel approach.

Authors:

An Sen Tan Joe Poe Sheng Yeong Chi Peng Timothy Lai Chong Hui Clara Ong Bernett Lee Jeffrey Chun Tatt Lim Aye Aye Thike Jabed Iqbal Rebecca Alexandra Dent Elaine Hsuen Lim Puay Hoon Tan

Virchows Arch 2019 Dec 12;475(6):709-725. Epub 2019 Aug 12.

Division of Pathology, Singapore General Hospital, 20 College Road, Academia, Level 7, Diagnostics Tower, Singapore, 169856, Singapore.

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December 2019

Prognostic role of immune infiltrates in breast ductal carcinoma in situ.

Authors:

Xiao-Yang Chen Joe Yeong Aye Aye Thike Boon Huat Bay Puay Hoon Tan

Breast Cancer Res Treat 2019 Aug 27;177(1):17-27. Epub 2019 May 27.

Department of Anatomical Pathology, Singapore General Hospital, Singapore, Singapore.

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August 2019

Behaviour and characteristics of low-grade ductal carcinoma in situ of the breast: literature review and single-centre retrospective series.

Authors:

Valerie Cui Yun Koh Jeffrey Chun Tatt Lim Aye Aye Thike Poh Yian Cheok Minn Minn Myint Thu Huihua Li Veronique Kiak Mien Tan Kong Wee Ong Benita Kiat Tee Tan Gay Hui Ho Shyamala Thilagaratnam Jill Su Lin Wong Fuh Yong Wong Ian Ogilvie Ellis Puay Hoon Tan

Histopathology 2019 Jun 28;74(7):970-987. Epub 2019 Mar 28.

Division of Pathology, Singapore General Hospital, Singapore.

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June 2019

Prognostic value of CD8 + PD-1+ immune infiltrates and PDCD1 gene expression in triple negative breast cancer.

Authors:

Joe Yeong Jeffrey Chun Tatt Lim Bernett Lee Huihua Li Clara Chong Hui Ong Aye Aye Thike Wei Hseun Yeap Yi Yang Ansel Yi Herh Lim Timothy Kwang Yong Tay Jin Liu Siew-Cheng Wong Jinmiao Chen Elaine Hsuen Lim Jabed Iqbal Rebecca Dent Evan W Newell Puay Hoon Tan

J Immunother Cancer 2019 02 6;7(1):34. Epub 2019 Feb 6.

Division of Pathology, Singapore General Hospital, 20 College Road, Academia, Level 7, Singapore, 169856, Singapore.

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February 2019

Elevated WBP2 Expression in HER2-positive Breast Cancers Correlates with Sensitivity to Trastuzumab-based Neoadjuvant Therapy: A Retrospective and Multicentric Study.

Authors:

Shin-Ae Kang Jye Swei Guan Hock Jin Tan Tinghine Chu Aye Aye Thike Cristina Bernadó Joaquín Arribas Chow Yin Wong Puay Hoon Tan Mihir Gudi Thomas Choudary Putti Joohyuk Sohn Swee Ho Lim Soo Chin Lee Yoon Pin Lim

Clin Cancer Res 2019 04 28;25(8):2588-2600. Epub 2018 Dec 28.

Department of Biochemistry, Yong Loo Lin School of Medicine, National University of Singapore, Singapore.

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April 2019

Genomic profile of breast sarcomas: a comparison with malignant phyllodes tumours.

Authors:

Sue Zann Lim Cedric Chuan Young Ng Vikneswari Rajasegaran Peiyong Guan Sathiyamoorthy Selvarajan Aye Aye Thike Nur Diyana Binte Md Nasir Valerie Cui Yun Koh Benita Kiat Tee Tan Kong Wee Ong Bin Tean Teh Puay Hoon Tan

Breast Cancer Res Treat 2019 Apr 3;174(2):365-373. Epub 2018 Dec 3.

Division of Pathology, Singapore General Hospital, Level 7, Diagnostics Tower, Academia, 20 College Road, Singapore, 169856, Singapore.

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April 2019

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