Publications by authors named "Aydar A Ishmukhametov"

7 Publications

  • Page 1 of 1

Towards effective COVID‑19 vaccines: Updates, perspectives and challenges (Review).

Int J Mol Med 2020 Jul 6;46(1):3-16. Epub 2020 May 6.

Department of Forensic Sciences and Toxicology, Faculty of Medicine, University of Crete, 71003 Heraklion, Greece.

In the current context of the pandemic triggered by SARS-COV-2, the immunization of the population through vaccination is recognized as a public health priority. In the case of SARS‑COV‑2, the genetic sequencing was done quickly, in one month. Since then, worldwide research has focused on obtaining a vaccine. This has a major economic impact because new technological platforms and advanced genetic engineering procedures are required to obtain a COVID‑19 vaccine. The most difficult scientific challenge for this future vaccine obtained in the laboratory is the proof of clinical safety and efficacy. The biggest challenge of manufacturing is the construction and validation of production platforms capable of making the vaccine on a large scale.
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http://dx.doi.org/10.3892/ijmm.2020.4596DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7255458PMC
July 2020

A Chemographic Audit of anti-Coronavirus Structure-activity Information from Public Databases (ChEMBL).

Mol Inform 2020 12 14;39(12):e2000080. Epub 2020 May 14.

Chemoinformatics Laboratory, UMR 7140 CNRS/University of Strasbourg, 4, rue Blaise Pascal, 67000, Strasbourg.

Discovery of drugs against newly emerged pathogenic agents like the SARS-CoV-2 coronavirus (CoV) must be based on previous research against related species. Scientists need to get acquainted with and develop a global oversight over so-far tested molecules. Chemography (herein used Generative Topographic Mapping, in particular) places structures on a human-readable 2D map (obtained by dimensionality reduction of the chemical space of molecular descriptors) and is thus well suited for such an audit. The goal is to map medicinal chemistry efforts so far targeted against CoVs. This includes comparing libraries tested against various virus species/genera, predicting their polypharmacological profiles and highlighting often encountered chemotypes. Maps are challenged to provide predictive activity landscapes against viral proteins. Definition of "anti-CoV" map zones led to selection of therein residing 380 potential anti-CoV agents, out of a vast pool of 800 M organic compounds.
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http://dx.doi.org/10.1002/minf.202000080DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7267182PMC
December 2020

Simplistic perylene-related compounds as inhibitors of tick-borne encephalitis virus reproduction.

Bioorg Med Chem Lett 2020 05 9;30(10):127100. Epub 2020 Mar 9.

Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry RAS, Moscow 117997, Russia.

Rigid amphipathic fusion inhibitors are potent broad-spectrum antivirals based on the perylene scaffold, usually decorated with a hydrophilic group linked via ethynyl or triazole. We have sequentially simplified these structures by removing sugar moiety, then converting uridine to aniline, then moving to perylenylthiophenecarboxylic acids and to perylenylcarboxylic acid. All these polyaromatic compounds, as well as antibiotic heliomycin, still showed pronounced activity against tick-borne encephalitis virus (TBEV) with limited toxicity in porcine embryo kidney (PEK) cell line. 5-(Perylen-3-yl)-2-thiophenecarboxylic acid (5a) showed the highest antiviral activity with 50% effective concentration of approx. 1.6 nM.
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http://dx.doi.org/10.1016/j.bmcl.2020.127100DOI Listing
May 2020

Comparison of the Immunogenicity and Safety of Two Pediatric TBE Vaccines Based on the Far Eastern and European Virus Subtypes.

Adv Virol 2019 24;2019:5323428. Epub 2019 Dec 24.

Federal State Budgetary Scientific Institution "Chumakov Federal Scientific Center for Research and Development of Immune-and-biological Products of Russian Academy of Sciences" (FSBSI "Chumakov FSC R&D IBP RAS"), 108819 Moscow, Russia.

Up to 10,000 cases of tick-borne encephalitis are registered annually, 20% of which occur in children under 17 years of age. A comparison of the immunogenicity and safety between a new pediatric Tick-E-Vac vaccine based on the TBEV strain Sofjin and FSME-IMMUN Junior vaccine was performed in the Sverdlovsk region. The vaccine strains differ from strains of the Siberian subtype of TBEV that dominates in the region. The study was performed on 163 children aged 1 to 15, who received one of the vaccines according to either a conventional or rapid vaccination schedule. Immunogenicity was assessed based on the seroprotection rates and titers of virus-neutralizing antibodies. There were no significant differences in either the immunogenicity or reactogenicity of the pediatric vaccines based on strains of the Far Eastern or European subtypes of TBEV. Under both vaccination schedules, 30 days after the second injection, seroprotection rates were 100% for Tick-E-Vac and greater than 95% for FSME-IMMUN Junior, while the geometric mean titer of TBEV-neutralizing antibodies was at least 2,4 log (1 : 250) for either vaccine. Fourteen days after the second injection according to the rapid schedule, seroprotection rates were significantly lower, ranging from 50% to 63% regardless of the vaccine used. The observed adverse reactions were mild or moderate for both vaccines under both vaccination schedules, with total adverse event rates of less than 25%. Reactogenicity was not associated with the gender or age of the recipients. There were no statistically significant differences in the incidence of adverse reactions between the group of subjects who were baseline seronegative or seropositive. However, 14 days after the second vaccine injection according to the rapid schedule, a statistically significant difference in nAbs titers was identified between groups of children with and without reported reactions.
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http://dx.doi.org/10.1155/2019/5323428DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6942698PMC
December 2019

Hemorrhagic Fever with Renal Syndrome, Russia.

Emerg Infect Dis 2019 12;25(12):2325-2328

In Russia, 131,590 cases of hemorrhagic fever with renal syndrome caused by 6 different hantaviruses were reported during 2000-2017. Most cases, 98.4%, were reported in western Russia. The average case-fatality rate was 0.4%, and strong regional differences were seen, depending on the predominant virus type.
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http://dx.doi.org/10.3201/eid2512.181649DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6874259PMC
December 2019

Severe hantavirus disease in children.

J Clin Virol 2018 04 31;101:66-68. Epub 2018 Jan 31.

Institute of Medical Virology, Helmut-Ruska-Haus, Charité School of Medicine, Berlin, Germany. Electronic address:

Background: Very recently, a novel European hantavirus, Sochi virus, has been discovered which causes severe courses of hantavirus disease with a case fatality rate of about 15 percent.

Objectives: We aimed to study to which extent and with which clinical severity children were affected by Sochi virus infection.

Study Design: Sochi virus infection of patients was confirmed by molecular, serological, and epizoonotic studies. Clinical and laboratory parameters were analyzed for the age group of up to 15 years (n = 6) in comparison to all older patients (n = 56).

Results: 9.7 percent of patients with hantavirus disease studied (6/62) were up to 15 years old. The children showed moderate to severe clinical courses similarly to the situation in adults.

Conclusions: While children are in general considered to be less affected by hantavirus infections than adults, in case of highly pathogenic hantaviruses, such as Sochi virus, frequency of clinical cases as well as their clinical course are comparable between children and adults. Therefore, hantavirus disease, particularly in regions endemic to highly pathogenic hantaviruses, should be considered in cases of unclear fever and kidney/pulmonary failure in children.
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http://dx.doi.org/10.1016/j.jcv.2018.01.018DOI Listing
April 2018

Life-Threatening Sochi Virus Infections, Russia.

Emerg Infect Dis 2015 Dec;21(12):2204-8

Sochi virus was recently identified as a new hantavirus genotype carried by the Black Sea field mouse, Apodemus ponticus. We evaluated 62 patients in Russia with Sochi virus infection. Most clinical cases were severe, and the case-fatality rate was as high as 14.5%.
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http://dx.doi.org/10.3201/eid2112.150891DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4672424PMC
December 2015