Ayako Tsuchiya

Ayako Tsuchiya

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Ayako Tsuchiya

Ayako Tsuchiya

Publications by authors named "Ayako Tsuchiya"

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Chandelier Illumination for Descemet Membrane Endothelial Keratoplasty.

Cornea 2017 Sep;36(9):1155-1157

*Department of Ophthalmology, Yokohama Minami Kyosai Hospital, Kanagawa, Japan; †Department of Ophthalmology, Yokohama City University School of Medicine, Yokohama, Kanagawa, Japan; ‡Department of Ophthalmology, Heart Life Hospital, Okinawa, Japan; §Department of Ophthalmology, Ryukyu University, Okinawa, Japan; and ¶Department of Ophthalmology, Saitama Medical University, Saitama, Japan.

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http://dx.doi.org/10.1097/ICO.0000000000001254DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5542790PMC
September 2017

Combination of PKCε Activation and PTP1B Inhibition Effectively Suppresses Aβ-Induced GSK-3β Activation and Tau Phosphorylation.

Mol Neurobiol 2016 09 2;53(7):4787-97. Epub 2015 Sep 2.

Division of Bioinformation, Department of Physiology, Hyogo College of Medicine, Nishinomiya, 663-8501, Japan.

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http://dx.doi.org/10.1007/s12035-015-9405-xDOI Listing
September 2016

DCP-LA Activates Cytosolic PKCε by Interacting with the Phosphatidylserine Binding/Associating Sites Arg50 and Ile89 in the C2-Like Domain.

Cell Physiol Biochem 2015 20;37(1):193-200. Epub 2015 Aug 20.

Division of Bioinformation, Department of Physiology, Hyogo College of Medicine, Nishinomiya, Japan.

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http://dx.doi.org/10.1159/000430344DOI Listing
May 2016

Phosphatidylinositol Induces Caspase-Independent Apoptosis of Malignant Pleural Mesothelioma Cells by Accumulating AIF in the Nucleus.

Cell Physiol Biochem 2015 18;36(3):1037-48. Epub 2015 Jun 18.

Division of Respiratory Medicine, Department of Internal Medicine, Hyogo College of Medicine, Nishinomiya, Japan.

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http://dx.doi.org/10.1159/000430277DOI Listing
March 2016

Amyloid-β peptide increases cell surface localization of α7 ACh receptor to protect neurons from amyloid β-induced damage.

Biochem Biophys Res Commun 2015 Dec 4-11;468(1-2):157-60. Epub 2015 Nov 4.

Division of Bioinformation, Department of Physiology, Hyogo College of Medicine, 1-1 Mukogawa-cho, Nishinomiya 663-8501, Japan. Electronic address:

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http://dx.doi.org/10.1016/j.bbrc.2015.10.141DOI Listing
March 2016

Irinotecan induces cell cycle arrest, but not apoptosis or necrosis, in Caco-2 and CW2 colorectal cancer cell lines.

Pharmacology 2015 1;95(3-4):154-9. Epub 2015 Apr 1.

Division of Bioinformation, Department of Physiology, Hyogo College of Medicine, Nishinomiya, Japan.

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http://dx.doi.org/10.1159/000381029DOI Listing
January 2016

HUHS1015 Suppresses Colonic Cancer Growth by Inducing Necrosis and Apoptosis in Association with Mitochondrial Damage.

Anticancer Res 2016 Jan;36(1):39-48

Division of Bioinformation, Department of Physiology and Division of Respiratory Medicine, Hyogo College of Medicine, Mukogawa-cho, Nishinomiya, Japan

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January 2016

Phosphatidylinositol Derivatives Induce Gastric Cancer Cell Apoptosis by Accumulating AIF and AMID in the Nucleus.

Anticancer Res 2015 Dec;35(12):6563-71

Division of Bioinformation, Department of Physiology and Division of Respiratory Medicine, Hyogo College of Medicine, Nishinomiya, Japan

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December 2015

Adipose-derived stem cell-conditioned medium ameliorates antidepression-related behaviors in the mouse model of Alzheimer's disease.

Neurosci Lett 2015 Nov 17;609:53-7. Epub 2015 Oct 17.

Division of Bioinformation, Department of Physiology, Hyogo College of Medicine, Nishinomiya, Japan. Electronic address:

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http://dx.doi.org/10.1016/j.neulet.2015.10.023DOI Listing
November 2015

Diarachidonoylphosphoethanolamine induces apoptosis of malignant pleural mesothelioma cells through a Trx/ASK1/p38 MAPK pathway.

J Pharmacol Sci 2015 Nov 23;129(3):160-8. Epub 2015 Oct 23.

Division of Bioinformation, Department of Physiology, Hyogo College of Medicine, Nishinomiya 663-8501, Japan. Electronic address:

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http://dx.doi.org/10.1016/j.jphs.2015.10.003DOI Listing
November 2015

HUHS1015 induces necroptosis and caspase-independent apoptosis of MKN28 human gastric cancer cells in association with AMID accumulation in the nucleus.

Anticancer Agents Med Chem 2015 ;15(2):242-7

Division of Bioinformation, Department of Physiology, Hyogo College of Medicine, 1-1 Mukogawa-cho, Nishinomiya 663-8501, Japan.

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October 2015

Naftopidil is useful for the treatment of malignant pleural mesothelioma.

Pharmacology 2014 4;94(3-4):163-9. Epub 2014 Oct 4.

Division of Respiratory Medicine, Department of Internal Medicine, Nishinomiya, Japan.

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https://www.karger.com/Article/FullText/368050
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http://dx.doi.org/10.1159/000368050DOI Listing
October 2015

Anticancer effect of adenosine on gastric cancer via diverse signaling pathways.

World J Gastroenterol 2015 Oct;21(39):10931-5

Ayako Tsuchiya, Tomoyuki Nishizaki, Division of Bioinformation, Department of Physiology, Hyogo College of Medicine, Nishinomiya 663-8501, Japan.

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http://dx.doi.org/10.3748/wjg.v21.i39.10931DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4607894PMC
October 2015

Diarachidonoylphosphoethanolamine induces necrosis/necroptosis of malignant pleural mesothelioma cells.

Cell Signal 2015 Sep 22;27(9):1713-9. Epub 2015 May 22.

Division of Bioinformation, Department of Physiology, Hyogo College of Medicine, 1-1 Mukogawa-cho, Nishinomiya 663-8501, Japan. Electronic address:

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http://dx.doi.org/10.1016/j.cellsig.2015.05.007DOI Listing
September 2015

Oleic acid stimulates glucose uptake into adipocytes by enhancing insulin receptor signaling.

J Pharmacol Sci 2014 13;126(4):337-43. Epub 2014 Nov 13.

Division of Bioinformation, Department of Physiology, Institute for Advanced Medical Sciences, Hyogo College of Medicine, Japan.

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http://jlc.jst.go.jp/DN/JST.JSTAGE/jphs/14182FP?lang=en&
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http://dx.doi.org/10.1254/jphs.14182FPDOI Listing
August 2015

Rac1 and ROCK are implicated in the cell surface delivery of GLUT4 under the control of the insulin signal mimetic diDCP-LA-PE.

J Pharmacol Sci 2015 Aug 11;128(4):179-84. Epub 2015 Jul 11.

Division of Bioinformation, Department of Physiology, Hyogo College of Medicine, Nishinomiya, Japan. Electronic address:

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http://dx.doi.org/10.1016/j.jphs.2015.07.001DOI Listing
August 2015

Dipalmitoleoylphosphoethanolamine as a PP2A enhancer obstructs insulin signaling by promoting Ser/Thr dephosphorylation of Akt.

Cell Physiol Biochem 2014 11;34(3):617-27. Epub 2014 Aug 11.

Division of Bioinformation, Department of Physiology, Hyogo College of Medicine, Nishinomiya, Japan.

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http://dx.doi.org/10.1159/000363027DOI Listing
June 2015

The newly synthesized anticancer drug HUHS1015 is useful for treatment of human gastric cancer.

Cancer Chemother Pharmacol 2015 Mar 8;75(3):527-35. Epub 2015 Jan 8.

Division of Bioinformation, Department of Physiology, Hyogo College of Medicine, 1-1 Mukogawa-cho, Nishinomiya, 663-8501, Japan.

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http://dx.doi.org/10.1007/s00280-014-2661-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4341015PMC
March 2015

PTP1B inhibition causes Rac1 activation by enhancing receptor tyrosine kinase signaling.

Cell Physiol Biochem 2014 9;33(4):1097-105. Epub 2014 Apr 9.

Division of Bioinformation, Department of Physiology, Hyogo College of Medicine, Nishinomiya, Japan.

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http://dx.doi.org/10.1159/000358679DOI Listing
January 2015

1-[2-(2-Methoxyphenylamino)ethylamino]-3-(naphthalene-1- yloxy)propan-2-ol may be a promising anticancer drug.

Molecules 2014 Dec 19;19(12):21462-72. Epub 2014 Dec 19.

Laboratory of Chemical Biology, Advanced Medicinal Research Center, Hyogo University of Health Sciences, 1-3-6 Minatojima, Chuo-ku, Kobe 650-8530, Japan.

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http://dx.doi.org/10.3390/molecules191221462DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6271752PMC
December 2014

Hyperphosphorylation of Tau at Ser396 occurs in the much earlier stage than appearance of learning and memory disorders in 5XFAD mice.

Behav Brain Res 2014 Nov 27;274:302-6. Epub 2014 Aug 27.

Division of Bioinformation, Department of Physiology, Hyogo College of Medicine, Nishinomiya, Japan. Electronic address:

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http://dx.doi.org/10.1016/j.bbr.2014.08.034DOI Listing
November 2014

DCP-LA-phosphatidylinositol and its enantiomer exhibit different bioactivities.

Cell Physiol Biochem 2014 31;33(2):300-9. Epub 2014 Jan 31.

Division of Bioinformation, Department of Physiology, Hyogo College of Medicine, Nishinomiya, Japan.

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http://dx.doi.org/10.1159/000356670DOI Listing
October 2014

Newly synthesized anticancer drug HUHS1015 is effective on malignant pleural mesothelioma.

Cancer Sci 2014 Jul 21;105(7):883-9. Epub 2014 May 21.

Division of Bioinformation, Department of Physiology, Hyogo College of Medicine, Nishinomiya, Japan.

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http://dx.doi.org/10.1111/cas.12429DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4317914PMC
July 2014

Free fatty acids inhibit protein tyrosine phosphatase 1B and activate Akt.

Cell Physiol Biochem 2013 27;32(4):871-9. Epub 2013 Sep 27.

Department of Thoracic Oncology, Hyogo College of Medicine, Nishinomiya, Japan.

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http://dx.doi.org/10.1159/000354489DOI Listing
June 2014

A novel PP2A enhancer induces caspase-independent apoptosis of MKN28 gastric cancer cells with high MEK activity.

Cancer Lett 2014 May 4;347(1):123-8. Epub 2014 Feb 4.

Division of Bioinformation, Department of Physiology, Hyogo College of Medicine, 1-1 Mukogawa-cho, Nishinomiya 663-8501, Japan. Electronic address:

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http://dx.doi.org/10.1016/j.canlet.2014.01.034DOI Listing
May 2014

RE12 derivatives displaying Vaccinia H1-related phosphatase (VHR) inhibition in the presence of detergent and their anti-proliferative activity against HeLa cells.

Bioorg Med Chem 2014 May 18;22(9):2771-82. Epub 2014 Mar 18.

Synthetic Organic Chemistry Laboratory, RIKEN, 2-1 Hirosawa, Wako-shi, Saitama 351-0198, Japan; Tokyo Medical and Dental University, 1-5-45 Yushima, Bunkyo-ku, Tokyo 113-8510, Japan; RIKEN Center for Sustainable Resource Science, 2-1 Hirosawa, Wako, Saitama 351-0198, Japan; Graduate School of Science and Engineering, Saitama University, 255 Shimo-okubo, Sakura-ku, Saitama 338-8570, Japan; ERATO-JST, 2-1 Hirosawa, Wako-shi, Saitama 351-0198, Japan. Electronic address:

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http://dx.doi.org/10.1016/j.bmc.2014.03.012DOI Listing
May 2014

Dipalmitoleoyl-phosphatidylethanolamine induces apoptosis of NCI-H28 malignant mesothelioma cells.

Anticancer Res 2014 Apr;34(4):1759-64

Division of Bioinformation, Department of Physiology, Hyogo College of Medicine, 1-1 Mukogawa-cho, Nishinomiya 663-8501, Japan.

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April 2014

Crosstalk between PI3 kinase/PDK1/Akt/Rac1 and Ras/Raf/MEK/ERK pathways downstream PDGF receptor.

Cell Physiol Biochem 2013 17;31(6):905-13. Epub 2013 Jun 17.

Division of Bioinformation, Department of Physiology, Hyogo College of Medicine, Nishinomiya, Japan.

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http://dx.doi.org/10.1159/000350108DOI Listing
February 2014

Effects of newly synthesized DCP-LA-phospholipids on protein kinase C and protein phosphatases.

Cell Physiol Biochem 2013 5;31(4-5):555-64. Epub 2013 Apr 5.

Division of Bioinformation, Department of Physiology, Hyogo College of Medicine, 1-1 Mukogawa-cho, Nishinomiya 663-8501, Japan.

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https://www.karger.com/Article/FullText/350076
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http://dx.doi.org/10.1159/000350076DOI Listing
December 2013

Diacylglycerol promotes GLUT4 translocation to the cell surface in a PKCε-dependent and PKCλ/ι and -ζ-independent manner.

Life Sci 2013 Aug 22;93(5-6):240-6. Epub 2013 Jun 22.

Division of Bioinformation, Department of Physiology, Hyogo College of Medicine, 1-1 Mukogawa-cho, Nishinomiya 663-8501, Japan.

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http://dx.doi.org/10.1016/j.lfs.2013.06.014DOI Listing
August 2013

Contribution of Cage-Shaped Structure of Physalins to Their Mode of Action in Inhibition of NF-κB Activation.

ACS Med Chem Lett 2013 Aug 6;4(8):730-5. Epub 2013 Jun 6.

Synthetic Organic Chemistry Laboratory, RIKEN , 2-1 Hirosawa, Wako, Saitama 351-0198, Japan ; RIKEN Center for Sustainable Resource Science , 2-1 Hirosawa, Wako, Saitama 351-0198, Japan ; ERATO-JST , 2-1 Hirosawa, Wako, Saitama 351-0198, Japan.

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http://pubs.acs.org/doi/10.1021/ml400144e
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http://dx.doi.org/10.1021/ml400144eDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4027496PMC
August 2013

Indomethacin serves as a potential inhibitor of protein phosphatases.

Cell Physiol Biochem 2012 20;30(4):1014-22. Epub 2012 Sep 20.

Division of Bioinformation, Department of Physiology, Hyogo College of Medicine, 1-1 Mukogawa-cho, Nishinomiya, Japan.

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http://dx.doi.org/10.1159/000341478DOI Listing
June 2013

The linoleic acid derivative DCP-LA increases membrane surface localization of the α7 ACh receptor in a protein 4.1N-dependent manner.

Biochem J 2013 Mar;450(2):303-9

Division of Bioinformation, Department of Physiology, Hyogo College of Medicine, 1-1 Mukogawa-cho, Nishinomiya 663-8501, Japan.

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http://biochemj.org/lookup/doi/10.1042/BJ20121348
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http://dx.doi.org/10.1042/BJ20121348DOI Listing
March 2013

Novel indomethacin action: selective and direct activation of protein kinase C-ε.

Cell Physiol Biochem 2012 2;30(3):771-7. Epub 2012 Aug 2.

Division of Bioinformation, Department of Physiology, Hyogo College of Medicine, 1-1 Mukogawa-cho, Nishinomiya 663-8501, Japan.

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http://dx.doi.org/10.1159/000341456DOI Listing
December 2012

Intracellularly transported adenosine induces apoptosis in [corrected] MCF-7 human breast cancer cells by accumulating AMID in the nucleus.

Cancer Lett 2012 Aug 28;321(1):65-72. Epub 2012 Feb 28.

Division of Bioinformation, Department of Physiology, Hyogo College of Medicine, Mukogawa-cho, Nishinomiya, Japan.

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http://dx.doi.org/10.1016/j.canlet.2012.02.023DOI Listing
August 2012

Development of a Vaccinia H1-related (VHR) phosphatase inhibitor with a nonacidic phosphate-mimicking core structure.

ChemMedChem 2011 Apr 9;6(4):617-22. Epub 2011 Mar 9.

RIKEN Advanced Science Institute, 2-1 Hirosawa, Wako-shi, Saitama 351-0198, Japan.

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http://dx.doi.org/10.1002/cmdc.201100107DOI Listing
April 2011

Hereditary rimmed vacuole myopathy showing interstitial amyloid deposition in muscle tissue.

Muscle Nerve 2009 Sep;40(3):472-5

Department of Neurology, Ishikawa Prefectural Central Hospital, 2-1 Kuratsukihigashi, Kanazawa 920-8530, Japan.

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http://dx.doi.org/10.1002/mus.21373DOI Listing
September 2009

AH amyloidosis associated with an immunoglobulin heavy chain variable region (VH1) fragment: a case report.

Amyloid 2008 Jun;15(2):125-8

Department of Medicine (Neurology and Rheumatology), Shinshu University School of Medicine, Matsumoto, Japan.

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http://dx.doi.org/10.1080/13506120802006229DOI Listing
June 2008

Amyloidogenic transthyretin Val30Met homozygote showing unusually early-onset familial amyloid polyneuropathy.

Muscle Nerve 2008 Jun;37(6):796-803

Department of Neurology and Rheumatology, Shinshu University School of Medicine, Matsumoto 390-8621, Japan.

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http://doi.wiley.com/10.1002/mus.21028
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http://dx.doi.org/10.1002/mus.21028DOI Listing
June 2008

Marked regression of abdominal fat amyloid in patients with familial amyloid polyneuropathy during long-term follow-up after liver transplantation.

Liver Transpl 2008 Apr;14(4):563-70

Department of Medicine (Neurology), Shinshu University School of Medicine, Matsumoto, Japan.

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http://dx.doi.org/10.1002/lt.21395DOI Listing
April 2008

Diurnal blood pressure variation in patients with sleep apnea syndrome.

Hypertens Res 2008 Feb;31(2):185-91

Division of Nephrology and Hypertension, Department of Internal Medicine, St. Marianna University School of Medicine, Kawasaki, Japan.

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http://dx.doi.org/10.1291/hypres.31.185DOI Listing
February 2008

Functions of cyclin D1 as an oncogene and regulation of cyclin D1 expression.

Cancer Sci 2007 May 14;98(5):629-35. Epub 2007 Mar 14.

Department of Biosciences and Informatics, Faculty of Science and Technology, Keio University, Yokohama 223-8522, Japan.

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http://dx.doi.org/10.1111/j.1349-7006.2007.00449.xDOI Listing
May 2007

Involvement of nuclear accumulation of heat shock protein 27 in leptomycin B-induced apoptosis in HeLa cells.

J Antibiot (Tokyo) 2005 Dec;58(12):810-6

Department of Biosciences and Informatics, Faculty of Science and Technology, Keio University, 3-14-1 Hiyoshi, Kohoku-ku, Yokohama 223-8522, Japan.

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http://www.nature.com/articles/ja2005108
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http://dx.doi.org/10.1038/ja.2005.108DOI Listing
December 2005

Synthesis of the naphthalene-derived inhibitors against Cdc25A dual-specificity protein phosphatase and their biological activity.

Bioorg Med Chem Lett 2005 Jan;15(1):61-5

Department of Chemistry, Faculty of Science and Technology, Keio University, Hiyoshi 3-14-1, Kohoku-ku, Yokohama 223-8522, Japan.

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http://dx.doi.org/10.1016/j.bmcl.2004.10.034DOI Listing
January 2005