Publications by authors named "Axel Ullrich"

100Publications

Lung cancer stem cells and their aggressive progeny, controlled by EGFR/MIG6 inverse expression, dictate a novel NSCLC treatment approach.

Oncotarget 2019 Apr 2;10(26):2546-2560. Epub 2019 Apr 2.

Department of Molecular Biology, Max-Planck Institute of Biochemistry, Martinsried, Munich, 82152, Germany.

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April 2019

The Gly385(388)Arg Polymorphism of the FGFR4 Receptor Regulates Hepatic Lipogenesis Under Healthy Diet.

J Clin Endocrinol Metab 2019 06;104(6):2041-2053

Department of Internal Medicine, Division of Endocrinology, Diabetology, Vascular Disease, Nephrology and Clinical Chemistry, University of Tübingen, Tübingen, Germany.

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June 2019

GAS6-expressing and self-sustaining cancer cells in 3D spheroids activate the PDK-RSK-mTOR pathway for survival and drug resistance.

Mol Oncol 2017 10 26;11(10):1430-1447. Epub 2017 Jul 26.

Department of Molecular Biology, Max-Planck-Institute of Biochemistry, Martinsried, Germany.

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October 2017

Sunitinib specifically augments glucose-induced insulin secretion.

Cell Signal 2017 08 24;36:91-97. Epub 2017 Apr 24.

German Center for Diabetes Research (DZD e.V.), Germany; Institute for Diabetes Research and Metabolic Diseases IDM of the Helmholtz Center Munich at the Eberhard-Karls-University of Tübingen, Germany; University Hospital Tübingen, Internal Medicine IV, Endocrinology, Diabetology, Angiology, Nephrology and Clinical Chemistry, Otfried-Müller-Str. 10, 72076 Tübingen, Germany. Electronic address:

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August 2017

Metformin Triggers Autophagy to Attenuate Drug-Induced Apoptosis in NSCLC Cells, with Minor Effects on Tumors of Diabetic Patients.

Neoplasia 2017 May 7;19(5):385-395. Epub 2017 Apr 7.

Department of Molecular Biology, Max-Planck-Institute of Biochemistry, Am Klopferspitz 18a, Martinsried, D-82152, Germany. Electronic address:

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May 2017

Membrane-proximal binding of STAT3 revealed by cancer-associated receptor variants.

Mol Cell Oncol 2016 May 24;3(3):e1145176. Epub 2016 Feb 24.

Max Planck Institute for Biochemistry, Department of Molecular Biology , Martinsried, Germany.

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May 2016

Novel compounds reducing IRS-1 serine phosphorylation for treatment of diabetes.

Bioorg Med Chem Lett 2016 Jan 28;26(2):424-428. Epub 2015 Nov 28.

MTA-SE Pathobiochemistry Research Group, Department of Medical Chemistry, Molecular Biology and Pathobiochemistry, Semmelweis University, 1444 Budapest, Hungary; Vichem Chemie Research Ltd, 1022 Budapest, Hungary. Electronic address:

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January 2016

Germline variant FGFR4  p.G388R exposes a membrane-proximal STAT3 binding site.

Nature 2015 Dec 16;528(7583):570-4. Epub 2015 Dec 16.

Max Planck Institute for Biochemistry, Department of Molecular Biology, Am Klopferspitz 18, 82152, Martinsried. Germany.

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December 2015

Activation of Cardiac Fibroblast Growth Factor Receptor 4 Causes Left Ventricular Hypertrophy.

Cell Metab 2015 Dec 1;22(6):1020-32. Epub 2015 Oct 1.

Katz Family Drug Discovery Center and Division of Nephrology and Hypertension, Department of Medicine, University of Miami Leonard M. Miller School of Medicine, Miami, FL 33136, USA; Department of Cell Biology and Anatomy, University of Miami Leonard M. Miller School of Medicine, Miami, FL 33136, USA. Electronic address:

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December 2015

Erk2 but not Erk1 regulates crosstalk between Met and EGFR in squamous cell carcinoma cell lines.

Mol Cancer 2015 Mar 4;14:54. Epub 2015 Mar 4.

Department of Molecular Biology, Max Planck Institute of Biochemistry, Am Klopferspitz 18, D-82152, Martinsried, Germany.

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March 2015

Combined inhibition of AXL, Lyn and p130Cas kinases block migration of triple negative breast cancer cells.

Cancer Biol Ther 2014 ;15(11):1571-82

a Department of Molecular Biology; Max-Planck-Institute of Biochemistry ; Martinsried , Germany.

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August 2015

Discovery and Biological Evaluation of Novel Dual EGFR/c-Met Inhibitors.

ACS Med Chem Lett 2014 Apr 30;5(4):298-303. Epub 2014 Jan 30.

Vichem Chemie Research Ltd. , 1022 Budapest, Hungary ; MTA-SE Pathobiochemistry Research Group, Department of Medical Chemistry, Semmelweis University , 1085 Budapest, Hungary ; Rational Drug-Design Laboratory Cooperation Research Centre, Semmelweis University , 1085 Budapest, Hungary.

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April 2014

Benzylidene-indolinones are effective as multi-targeted kinase inhibitor therapeutics against hepatocellular carcinoma.

Mol Oncol 2014 Oct 2;8(7):1266-77. Epub 2014 May 2.

Singapore OncoGenome Laboratory, Institute of Molecular and Cell Biology, A*STAR, Singapore; Department of Molecular Biology, Max-Planck-Institute of Biochemistry, Martinsried, Germany.

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October 2014

Bosutinib inhibits migration and invasion via ACK1 in KRAS mutant non-small cell lung cancer.

Mol Cancer 2014 Jan 24;13:13. Epub 2014 Jan 24.

Singapore OncoGenome Laboratory, Institute of Medical Biology, Agency of Science Technology and Research, Singapore, Singapore.

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January 2014

PTK 7 is a transforming gene and prognostic marker for breast cancer and nodal metastasis involvement.

PLoS One 2014 7;9(1):e84472. Epub 2014 Jan 7.

Department of Gynecology and Obstetrics, Red Cross Hospital, Munich, Germany ; Department of Gynecology and Gynecologic Oncology, Kliniken Essen-Mitte, Evangelische Huyssens-Stiftung, Essen, Germany.

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September 2014

NEK9 depletion induces catastrophic mitosis by impairment of mitotic checkpoint control and spindle dynamics.

Biochem Biophys Res Commun 2013 Dec 9;442(3-4):139-46. Epub 2013 May 9.

Max-Planck-Institute of Biochemistry, Department of Molecular Biology, Martinsried, Germany; Shinagawa R&D Center, Daiichi Sankyo Co. Ltd., Tokyo, Japan. Electronic address:

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December 2013

Inhibition of doxorubicin-induced HER3-PI3K-AKT signalling enhances apoptosis of ovarian cancer cells.

Mol Oncol 2012 Oct 20;6(5):516-29. Epub 2012 Jul 20.

Max-Planck-Institute of Biochemistry, Department of Molecular Biology, Martinsried, Germany.

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October 2012

Combinatorial treatment of mammospheres with trastuzumab and salinomycin efficiently targets HER2-positive cancer cells and cancer stem cells.

Int J Cancer 2012 Dec 21;131(12):2808-19. Epub 2012 May 21.

Pharmaceutical Biotechnology, Department of Pharmacy, Ludwig-Maximilians Universität München, Munich, Germany.

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December 2012

Toward the prognostic significance and therapeutic potential of HER3 receptor tyrosine kinase in human colon cancer.

Clin Cancer Res 2012 Feb 5;18(4):956-68. Epub 2011 Dec 5.

Department of Molecular Biology, Max-Planck-Institute of Biochemistry, Martinsried, Munich, Germany.

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February 2012

PRKX, TTBK2 and RSK4 expression causes Sunitinib resistance in kidney carcinoma- and melanoma-cell lines.

Int J Cancer 2012 Jul 28;131(2):E45-55. Epub 2012 Feb 28.

Department of Molecular Biology, Max-Planck-Institute, Martinsried, Germany.

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July 2012

Visceral obesity and inflammation markers in relation to serum prostate volume biomarkers among apparently healthy men.

Eur J Clin Invest 2011 Sep 7;41(9):987-94. Epub 2011 Mar 7.

Department of Biochemistry, College of Science, King Saud University, Riyadh, Saudi Arabia.

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September 2011

Somatic mutation in the ACK1 ubiquitin association domain enhances oncogenic signaling through EGFR regulation in renal cancer derived cells.

Mol Oncol 2010 Aug 19;4(4):323-34. Epub 2010 Mar 19.

Singapore OncoGenome Project, Institute of Medical Biology, A* STAR, 8A Biomedical Grove, #06-06 Immunos, Singapore 138648, Singapore.

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August 2010

A single nucleotide change in the mouse genome accelerates breast cancer progression.

Cancer Res 2010 Jan 12;70(2):802-12. Epub 2010 Jan 12.

Department of Molecular Biology, Max Planck Institute of Biochemistry, 85152 Martinsried, Germany.

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January 2010

Regulation of Akt(ser473) phosphorylation by choline kinase in breast carcinoma cells.

Mol Cancer 2009 Dec 31;8:131. Epub 2009 Dec 31.

Singapore OncoGenome Project, Institute of Medical Biology, A*STAR, 8A Biomedical Grove, 06-06 Immunos, Singapore.

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December 2009

Protein tyrosine phosphatases expression during development of mouse superior colliculus.

Exp Brain Res 2009 Dec 1;199(3-4):279-97. Epub 2009 Sep 1.

Department of Cell Morphology and Molecular Neurobiology, Faculty of Biology, Ruhr-University Bochum, Universitaetsstr 150, 44780, Bochum, Germany.

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December 2009

Negative regulation of the EGFR-MAPK cascade by actin-MAL-mediated Mig6/Errfi-1 induction.

Mol Cell 2009 Aug;35(3):291-304

Department of Molecular Biology, Max-Planck-Institute of Biochemistry, Martinsried, Germany.

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August 2009

Resistance to chemotherapy is associated with fibroblast growth factor receptor 4 up-regulation.

Clin Cancer Res 2009 Mar 24;15(6):2058-66. Epub 2009 Feb 24.

Department of Molecular Biology, Max-Planck-Institute of Biochemistry, Martinsried, Germany.

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March 2009

Effects of sunitinib on tumor hemodynamics and delivery of chemotherapy.

Int J Cancer 2009 Mar;124(6):1293-300

Department of Neurosurgery, Universitätsmedizin Charitè, Berlin, Germany.

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March 2009

UV-induced EGFR signal transactivation is dependent on proligand shedding by activated metalloproteases in skin cancer cell lines.

Int J Cancer 2009 Feb;124(3):531-9

Department of Molecular Biology, Max-Planck-Institute of Biochemistry, Martinsried, Germany.

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February 2009

HER3 is a determinant for poor prognosis in melanoma.

Clin Cancer Res 2008 Aug;14(16):5188-97

Department of Molecular Biology, Max-Planck Institute of Biochemistry, Munich, Germany.

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August 2008

Investigation of protein-tyrosine phosphatase 1B function by quantitative proteomics.

Mol Cell Proteomics 2008 Sep 31;7(9):1763-77. Epub 2008 May 31.

Department of Molecular Biology, Max Planck Institute of Biochemistry, Am Klopferspitz 18, 82152 Martinsried, Germany.

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September 2008

Paul Ehrlich's magic bullet concept: 100 years of progress.

Nat Rev Cancer 2008 06 12;8(6):473-80. Epub 2008 May 12.

Klaus Strebhardt is at the Department of Obstetrics and Gynaecology, School of Medicine, J.W. Goethe-University, Theodour-Stern-Kai 7, 60590 Frankfurt, Germany.

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June 2008

SHPS-1/SIRP1alpha contributes to interleukin-6 signalling.

Cell Signal 2008 Jul 21;20(7):1385-91. Epub 2008 Mar 21.

Department of Biochemistry, RWTH Aachen University, Pauwelsstrasse 30, D-52074 Aachen, Germany.

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July 2008

Development of Targeted Therapies in ErbB2-Positive Breast Cancer.

Breast Care (Basel) 2008;3(s1):3-6. Epub 2008 Apr 24.

Department of Obstetrics and Gynecology and Breast Cancer Center, Klinikum Offenbach GmbH, Kassel, Germany.

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April 2008

Nuclear translocation of the tumor marker pyruvate kinase M2 induces programmed cell death.

Cancer Res 2007 Feb;67(4):1602-8

Department of Molecular Biology, Max-Planck-Institute for Biochemistry, Martinsried, Germany.

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February 2007

Another look at imatinib mesylate.

N Engl J Med 2006 Dec;355(23):2481-2

Department of Obstetrics and Gynecology, School of Medicine, J.W. Goethe University, Frankfurt, Germany.

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December 2006

Tyrosine phosphorylated Par3 regulates epithelial tight junction assembly promoted by EGFR signaling.

EMBO J 2006 Nov 19;25(21):5058-70. Epub 2006 Oct 19.

Key Laboratory of Proteomics and Laboratory of Molecular Cell Biology, Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai, China.

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November 2006

Endothelin-1 inhibits adipogenesis: role of phosphorylation of Akt and ERK1/2.

FEBS Lett 2006 Oct 27;580(24):5765-71. Epub 2006 Sep 27.

Department of Molecular Biology, Max Planck Institute for Biochemistry, Am Klopferspitz 18, D-82152 Martinsried, Germany.

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October 2006

PTP-PEST phosphatase variations in human cancer.

Cancer Genet Cytogenet 2006 Oct;170(1):48-53

Department of Molecular Biology, Max-Planck-Institute of Biochemistry, Am Klopferspitz 18a, D-82152 Martinsried, Germany.

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October 2006

FGFR4 Arg388 allele is associated with resistance to adjuvant therapy in primary breast cancer.

J Clin Oncol 2006 Aug 5;24(23):3747-55. Epub 2006 Jul 5.

Department of Obstetrics and Gynecology, Institute of Pathology, and Institute for Medical Statistics and Epidemiology, Technical University of Munich, Munich, Germany.

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August 2006

Dissecting the epidermal growth factor receptor signal transactivation pathway.

Methods Mol Biol 2006 ;327:85-97

Pfizer Global Research and Development, Sandwich Laboratories, Kent, UK.

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July 2006

Mig6 is a negative regulator of EGF receptor-mediated skin morphogenesis and tumor formation.

Nat Med 2006 May 30;12(5):568-73. Epub 2006 Apr 30.

Department of Molecular Neurobiology, Max-Planck Institute of Neurobiology, Klopferspitz 18, 82152 Martinsried, Germany.

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May 2006

Estrogen transactivates EGFR via the sphingosine 1-phosphate receptor Edg-3: the role of sphingosine kinase-1.

J Cell Biol 2006 Apr;173(2):301-10

Signal Transduction Laboratory, Division of Human Immunology, Hanson Institute, Institute of Medical and Veterinary Science, Adelaide SA 5000, Australia.

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April 2006

Targeting polo-like kinase 1 for cancer therapy.

Nat Rev Cancer 2006 04;6(4):321-30

Department of Obstetrics and Gynecology, School of Medicine, J.W. Goethe-University, Theodore-Stern-Kai 7, 60590 Frankfurt, Germany.

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April 2006

EGFR signaling leads to downregulation of PTP-LAR via TACE-mediated proteolytic processing.

Cell Signal 2006 Sep 14;18(9):1515-27. Epub 2006 Feb 14.

Department of Molecular Biology, Max-Planck-Institute for Biochemistry, Am Klopferspitz 18A, D-82152 Martinsried, Germany.

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September 2006

EphB4 controls blood vascular morphogenesis during postnatal angiogenesis.

EMBO J 2006 Feb 19;25(3):628-41. Epub 2006 Jan 19.

Department of Neurosurgery, Faculty for Clinical Medicine of the University of Heidelberg, University Hospital Mannheim, Mannheim, Germany.

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February 2006

Structural basis for Gas6-Axl signalling.

EMBO J 2006 Jan 15;25(1):80-7. Epub 2005 Dec 15.

Max-Planck-Institut für Biochemie, Martinsried, Germany.

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January 2006

Drug discovery in the kinase inhibitory field using the Nested Chemical Library technology.

Assay Drug Dev Technol 2005 Oct;3(5):543-51

Peptide Biochemistry Research Group of Hungarian Academy of Sciences in Department of Medicinal Chemistry and Pathobiochemistry and Rational Drug Design Laboratory Cooperative Research Center, Semmelweis University, Budapest, Hungary.

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October 2005

GPCR-induced migration of breast carcinoma cells depends on both EGFR signal transactivation and EGFR-independent pathways.

Biol Chem 2005 Sep;386(9):845-55

Department of Molecular Biology, Max-Planck-Institute of Biochemistry, Am Klopferspitz 18A, D-82152 Martinsried, Germany.

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September 2005

FGFR4 GLY388 isotype suppresses motility of MDA-MB-231 breast cancer cells by EDG-2 gene repression.

Cell Signal 2006 Jun 18;18(6):783-94. Epub 2005 Aug 18.

Department of Molecular Biology, Max-Planck-Institute of Biochemistry, Am Klopferspitz 18a, D-82152 Martinsried, Germany.

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June 2006

Identification of MMP-15 as an anti-apoptotic factor in cancer cells.

J Biol Chem 2005 Oct 9;280(40):34123-32. Epub 2005 Aug 9.

Department of Molecular Biology, Max-Planck-Institute for Biochemistry, 82152 Martinsried, Germany.

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October 2005

Identification of a transcriptionally active hVH-5 pseudogene on 10q22.2.

Cancer Genet Cytogenet 2005 Jun;159(2):155-9

Department of Molecular Biology, Max-Planck-Institute of Biochemistry, Am Klopferspitz 18a, D-82152 Martinsried, Germany.

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June 2005

Anti-HER-3 MAbs inhibit HER-3-mediated signaling in breast cancer cell lines resistant to anti-HER-2 antibodies.

Int J Cancer 2005 Jul;115(4):519-27

Department of Molecular Biology, Max Planck Institute for Biochemistry, Martinsried, Munich, Germany.

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July 2005

Abl-kinase-sensitive levels of ERK5 and its intrinsic basal activity contribute to leukaemia cell survival.

EMBO Rep 2005 Jan;6(1):63-9

Department of Molecular Biology, Max Planck Institute of Biochemistry, Am Klopferspitz 18a, 82152 Martinsried, Germany.

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January 2005

Strategies to overcome resistance to targeted protein kinase inhibitors.

Nat Rev Drug Discov 2004 Dec;3(12):1001-10

Axxima Pharmaceuticals AG, Max-Lebsche-Platz 32, 81377 München, Germany.

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December 2004

The unique C-terminal tail of the mitogen-activated protein kinase ERK5 regulates its activation and nuclear shuttling.

J Biol Chem 2005 Jan 17;280(4):2659-67. Epub 2004 Nov 17.

Max-Planck-Institute of Biochemistry, Department of Molecular Biology, D-82152 Martinsried, Germany.

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January 2005

Tyrosine phosphorylation of PYK2 mediates heregulin-induced glioma invasion: novel heregulin/HER3-stimulated signaling pathway in glioma.

Int J Cancer 2005 Feb;113(5):689-98

Department of Molecular Biology, Max Planck Institute for Biochemistry, Munich, Germany.

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February 2005

Effect of tumor-associated mutant E-cadherin variants with defects in exons 8 or 9 on matrix metalloproteinase 3.

J Cell Physiol 2005 Mar;202(3):805-13

Technische Universität München, Klinikum rechts der Isar, Institut für Allgemeine Pathologie und Pathologische Anatomie, München, Germany.

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March 2005

Distinct ADAM metalloproteinases regulate G protein-coupled receptor-induced cell proliferation and survival.

J Biol Chem 2004 Nov 26;279(46):47929-38. Epub 2004 Aug 26.

Department of Molecular Biology, Max-Planck Institute of Biochemistry, Martinsried D-82152, Germany.

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November 2004

Protein tyrosine kinase Syk modulates EGFR signalling in human mammary epithelial cells.

Cell Signal 2004 Nov;16(11):1249-61

Department of Molecular Biology, Max-Planck-Institute of Biochemistry, Am Klopferspitz 18, D-82152 Martinsried, Germany.

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November 2004

Mammary gland remodeling depends on gp130 signaling through Stat3 and MAPK.

J Biol Chem 2004 Oct 30;279(42):44093-100. Epub 2004 Jul 30.

Laboratory of Genetics and Physiology, NIDDK, National Institutes of Health, Bethesda, Maryland 20892, USA.

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October 2004

Involvement of the FGFR4 Arg388 allele in head and neck squamous cell carcinoma.

Int J Cancer 2004 Aug;111(2):213-7

Department of Molecular Biology, Max Planck Institute for Biochemistry, Martinsried, Germany.

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August 2004

Oxidative and osmotic stress signaling in tumor cells is mediated by ADAM proteases and heparin-binding epidermal growth factor.

Mol Cell Biol 2004 Jun;24(12):5172-83

Department of Molecular Biology, Max Planck Institute of Biochemistry, D-82152 Martinsried, Germany.

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June 2004

Reactive oxygen species mediate Met receptor transactivation by G protein-coupled receptors and the epidermal growth factor receptor in human carcinoma cells.

J Biol Chem 2004 Jul 29;279(28):28970-8. Epub 2004 Apr 29.

Department of Molecular Biology, Max-Planck-Institute of Biochemistry, Am Klopferspitz 18A, D-82152 Martinsried, Germany.

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July 2004

The discovery of receptor tyrosine kinases: targets for cancer therapy.

Nat Rev Cancer 2004 05;4(5):361-70

Genentech, Inc., 1 DNA Way, South San Francisco, CA 94080, USA.

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May 2004

Interplay between mycobacteria and host signalling pathways.

Nat Rev Microbiol 2004 Mar;2(3):189-202

Axxima Pharmaceuticals AG, Max-Lebsche-Platz 32, 81377 Munich, Germany.

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March 2004

Cannabinoids induce cancer cell proliferation via tumor necrosis factor alpha-converting enzyme (TACE/ADAM17)-mediated transactivation of the epidermal growth factor receptor.

Cancer Res 2004 Mar;64(6):1943-50

Department of Molecular Biology, Max-Planck-Institute of Biochemistry, Am Klopferspitz 18A, D-82152 Martinsried, Germany.

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March 2004