Axel Le Cesne

Axel Le Cesne

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Axel Le Cesne

Publications by authors named "Axel Le Cesne"

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Basic Knowledge in Soft Tissue Sarcoma.

Cardiovasc Intervent Radiol 2019 Sep 24;42(9):1255-1261. Epub 2019 Jun 24.

Department of Interventional Radiology, Gustave Roussy, 114 Rue Edouard Vaillant, 94805, Villejuif, France.

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http://dx.doi.org/10.1007/s00270-019-02259-wDOI Listing
September 2019

PARP1 expression in soft tissue sarcomas is a poor-prognosis factor and a new potential therapeutic target.

Mol Oncol 2019 Jul 7;13(7):1577-1588. Epub 2019 Jun 7.

Predictive Oncology Laboratory, Marseille Cancer Research Center (CRCM), Institut Paoli-Calmettes, U1068 INSERM, U7258 CNRS, Aix-Marseille University, Marseille, France.

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http://dx.doi.org/10.1002/1878-0261.12522DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6599836PMC
July 2019

Patterns of Care and Outcome Radiation-Induced Soft Tissue Sarcomas.

Int J Radiat Oncol Biol Phys 2019 02 5;103(2):449-452. Epub 2018 Oct 5.

Department of Radiation Oncology, Sorbonne University, HU La Pitié Salpêtrière Charles Foix, Assistance-Publique des Hôpitaux de Paris, Paris, France.

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https://linkinghub.elsevier.com/retrieve/pii/S03603016183380
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http://dx.doi.org/10.1016/j.ijrobp.2018.09.028DOI Listing
February 2019

A comprehensive review of the current evidence for trabectedin in advanced myxoid liposarcoma.

Cancer Treat Rev 2019 Jan 15;72:37-44. Epub 2018 Nov 15.

Department of Medical Oncology, Gustave Roussy Institut, Villejuif, France.

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http://dx.doi.org/10.1016/j.ctrv.2018.11.003DOI Listing
January 2019

Preserving quality of life as a key treatment goal in advanced soft tissue sarcomas.

Expert Rev Anticancer Ther 2018 12 26;18(12):1241-1248. Epub 2018 Sep 26.

d Division of Surgical Oncology & Thoracic Surgery , Mannheim University Medical Center , Mannheim , Germany.

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https://www.tandfonline.com/doi/full/10.1080/14737140.2018.1
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http://dx.doi.org/10.1080/14737140.2018.1524298DOI Listing
December 2018

Making the Best of Available Options for Optimal Sarcoma Treatment.

Authors:
Axel Le Cesne

Oncology 2018 14;95 Suppl 1:11-20. Epub 2018 Dec 14.

Department of Medical Oncology, Institut Gustave Roussy, Villejuif, France.

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http://dx.doi.org/10.1159/000494861DOI Listing
December 2018

Consistent Margin-Status Reporting in Soft Tissue Sarcoma Is Essential to Establish Risk-Adapted Strategies Integrating Biology and Histotype in Perioperative Treatments.

J Clin Oncol 2018 08 7;36(22):2357-2358. Epub 2018 Jun 7.

Antonin Levy, Gustave Roussy Cancer Campus; INSERM U1030, Molecular Radiotherapy, Villejuif, France; Sylvie Bonvalot, Institut Curie; PSL Research University, Paris, France; Dario Callegaro, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy; Angela Botticella, Axel Le Cesne, Gustave Roussy Cancer Campus Villejuif, France; Alessandro Gronchi, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy; and Cécile Le Péchoux, Gustave Roussy Cancer Campus Villejuif, France.

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http://dx.doi.org/10.1200/JCO.2018.78.6657DOI Listing
August 2018

Efficacy and safety of regorafenib compared to placebo and to post-cross-over regorafenib in advanced non-adipocytic soft tissue sarcoma.

Eur J Cancer 2018 08 11;99:28-36. Epub 2018 Jun 11.

Department of Clinical Research and Innovation, Centre Oscar Lambret, 3 rue Combemale, 59000 Lille, France; Paris-Saclay University, Univ. Paris-Sud, CESP, INSERM, Gustave Roussy, 94805 Villejuif, France. Electronic address:

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http://dx.doi.org/10.1016/j.ejca.2018.05.008DOI Listing
August 2018

Quality of life and patients' expectations in soft tissue sarcoma.

Future Oncol 2018 May;14(10s):51-62

Department of Medical Oncology, Gustave Roussy, 114 Rue Edouard Vaillant, 94805 Villejuif, France.

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http://dx.doi.org/10.2217/fon-2018-0077DOI Listing
May 2018

Neoadjuvant Chemotherapy, Concurrent Chemoradiation, and Adjuvant Chemotherapy for High-Risk Extremity Soft Tissue Sarcoma.

Am Soc Clin Oncol Educ Book 2018 May;38:910-915

From the Department of Radiation Oncology, Dana-Farber Cancer Institute and Brigham and Women's Hospital, Boston, MA; Department of Adult Medicine, Gustave Roussy, Villejuif, France; Division of Medical Oncology, Sarcoma Program, Sylvester Comprehensive Cancer Center, Miami, FL.

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http://dx.doi.org/10.1200/EDBK_201421DOI Listing
May 2018

Is dose de-escalation possible in sarcoma patients treated with enlarged limb sparing resection?

Radiother Oncol 2018 Mar 7;126(3):493-498. Epub 2017 Nov 7.

Department of Radiation Oncology, Gustave Roussy, Université Paris-Saclay, Villejuif, France. Electronic address:

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http://dx.doi.org/10.1016/j.radonc.2017.10.026DOI Listing
March 2018

Perioperative Management of Extremity Soft Tissue Sarcomas.

J Clin Oncol 2018 01 8;36(2):118-124. Epub 2017 Dec 8.

Rick L. Haas, The Netherlands Cancer Institute, Amsterdam; Rick L. Haas, Michiel A.J. van de Sande, and Hans Gelderblom, Leiden University Medical Centre, Leiden, the Netherlands; Alessandro Gronchi, Fondazione IRCCS, Istituto Nazionale dei Tumori, Milan, Italy; Elizabeth H. Baldini, Brigham and Women's Hospital and Dana-Farber Cancer Institute, Boston, MA; Christina Messiou, The Royal Marsden Hospital and The Institute of Cancer Research, London, United Kingdom; Eva Wardelmann, University Hospital Münster, Münster, Germany; Axel Le Cesne, Institut Gustave Roussy, Villejuif, France.

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http://ascopubs.org/doi/10.1200/JCO.2017.74.7527
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http://dx.doi.org/10.1200/JCO.2017.74.7527DOI Listing
January 2018

Recent advances in managing gastrointestinal stromal tumor.

F1000Res 2017 14;6:1689. Epub 2017 Sep 14.

Département d'Oncologie Médicale, Gustave Roussy Institut, Villejuif, France.

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http://dx.doi.org/10.12688/f1000research.11118.1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5600003PMC
September 2017

Ten-Year Progression-Free and Overall Survival in Patients With Unresectable or Metastatic GI Stromal Tumors: Long-Term Analysis of the European Organisation for Research and Treatment of Cancer, Italian Sarcoma Group, and Australasian Gastrointestinal Trials Group Intergroup Phase III Randomized Trial on Imatinib at Two Dose Levels.

J Clin Oncol 2017 May 31;35(15):1713-1720. Epub 2017 Mar 31.

Paolo G. Casali, Fondazione Istituto di Ricovero e Cura a Carattere Scientifico, Istituto Nazionale Tumori and University of Milan; Elena Fumagalli and Alessandro Gronchi, Fondazione Istituto di Ricovero e Cura a Carattere Scientifico, Istituto Nazionale Tumori, Milano, Italy; John Zalcberg, Peter MacCallum Cancer Institute, East Melbourne, Victoria; Dusan Kotasek, Adelaide Cancer Centre, Kurralta Park and University of Adelaide, South Australia, Australia; Axel Le Cesne, Gustave Roussy, Villejuif; Jean-Yves Blay, NetSARC and Site de Recherche Intégrée sur le Cancer de Lyon, Centre Leon Berard, Lyon; Antoine Italiano, Institut Bergonie, Bordeaux, France; Peter Reichardt, HELIOS Klinikum Berlin-Buch, Berlin; Lars H. Lindner, Klinikum der Universitaet München, München; Viktor Grünwald, School Hannover, Hannover, Germany; Ian R. Judson and Winette van der Graaf, Royal Marsden Hospital, London, United Kingdom; Patrick Schöffski, Universitaire Ziekenhuizen Leuven, Campus Gasthuisberg, Leuven; Saskia Litière and Sandrine Marreaud, European Organisation for Research and Treatment of Cancer Headquarters, Brussels, Belgium; Serge Leyvraz, University Hospital, Lausanne, Switzerland; Antonio Lopez Pousa, Hospital De La Santa Creu I Sant Pau, Barcelona, Spain; Stefan Sleijfer and Jaap Verweij, Erasmus MC Cancer Institute, Erasmus University Medical Center, Rotterdam; Jan M. Kerst, The Netherlands Cancer Institute, Amsterdam; Pancras Hogendoorn, Leiden University Medical Center, Leiden; Winette van der Graaf, Radboud University, Medical Center Nijmegen, the Netherlands; and Piotr Rutkowski, Maria Sklodowska-Curie Memorial Cancer Centre and Institute of Oncology, Warsaw, Poland.

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http://ascopubs.org/doi/10.1200/JCO.2016.71.0228
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http://dx.doi.org/10.1200/JCO.2016.71.0228DOI Listing
May 2017

Improving treatment results with reference centres for rare cancers: where do we stand?

Eur J Cancer 2017 05 3;77:90-98. Epub 2017 Apr 3.

GSF-GETO/NETSARC, Centre Léon Bérard & Université Claude Bernard, Lyon, France.

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http://dx.doi.org/10.1016/j.ejca.2017.02.006DOI Listing
May 2017

Safety of raltegravir-based antiretroviral therapy in HIV-infected patients receiving multi-kinase inhibitors.

Invest New Drugs 2017 04 12;35(2):247-249. Epub 2016 Nov 12.

Department of Cancer Medicine, Gustave Roussy Cancer Campus, 114, rue Edouard Vaillant, 94800, Villejuif, France.

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http://dx.doi.org/10.1007/s10637-016-0405-0DOI Listing
April 2017

Key messages from the BFR14 trial of the French Sarcoma Group.

Future Oncol 2017 Feb 14;13(3):273-284. Epub 2016 Sep 14.

Department of Cancer Medicine, Gustave Roussy, University Paris-Saclay, Villejuif, France.

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http://dx.doi.org/10.2217/fon-2016-0409DOI Listing
February 2017

PDL1 expression is a poor-prognosis factor in soft-tissue sarcomas.

Oncoimmunology 2017 8;6(3):e1278100. Epub 2017 Feb 8.

Department of Molecular Oncology, Institut Paoli-Calmettes, Centre de Recherche en Cancérologie de Marseille, UMR1068 Inserm , Marseille, France.

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http://dx.doi.org/10.1080/2162402X.2016.1278100DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5384364PMC
February 2017

Primary Extremity Soft Tissue Sarcomas: Does Local Control Impact Survival?

Ann Surg Oncol 2017 Jan 4;24(1):194-201. Epub 2016 Aug 4.

Department of Radiation Oncology, Gustave Roussy, Université Paris-Saclay, Villejuif, France.

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http://dx.doi.org/10.1245/s10434-016-5462-2DOI Listing
January 2017

The importance of treating by histological subtype in advanced soft tissue sarcoma.

Future Oncol 2017 Jan;13(1s):23-31

Sarcoma Center Berlin-Brandenburg, HELIOS Klinikum Berlin-Buch, Berlin, Germany.

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http://dx.doi.org/10.2217/fon-2016-0500DOI Listing
January 2017

Individualized Pazopanib Dosing-Letter.

Clin Cancer Res 2016 12;22(24):6298

Department of Pharmacology, Gustave Roussy Cancer Campus, Villejuif, France.

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http://dx.doi.org/10.1158/1078-0432.CCR-16-2104DOI Listing
December 2016

Optimizing the use of trabectedin for advanced soft tissue sarcoma in daily clinical practice.

Future Oncol 2015 ;11(11 Suppl):3-14

2Department of Interdisciplinary Oncology, HELIOS Klinikum Berlin-Buch, Berlin, Germany.

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http://dx.doi.org/10.2217/fon.15.78DOI Listing
February 2016

Time to Definitive Failure to the First Tyrosine Kinase Inhibitor in Localized GI Stromal Tumors Treated With Imatinib As an Adjuvant: A European Organisation for Research and Treatment of Cancer Soft Tissue and Bone Sarcoma Group Intergroup Randomized Trial in Collaboration With the Australasian Gastro-Intestinal Trials Group, UNICANCER, French Sarcoma Group, Italian Sarcoma Group, and Spanish Group for Research on Sarcomas.

J Clin Oncol 2015 Dec 16;33(36):4276-83. Epub 2015 Nov 16.

Paolo G. Casali, Elena Fumagalli, and Alessandro Gronchi, Fondazione Istituto di Recovero e Cura a Carattere Scientifico Istituto Nazionale Tumori, Milano; Angelo P. Dei Tos, Azienda Unità Locale Socio Sanitaria 9 Treviso, Treviso, Italy; Axel Le Cesne, Gustave Roussy, Villejuif; Antoine Italiano, Institut Bergonie, Bordeaux; Antoine Adenis, Centre Oscar Lambret, Lille; Florence Duffaud, Hôpital de La Timone, Aix-Marseille Université, Marseille; Jean-Yves Blay, Centre Leon Berard, Lyon, France; Andres Poveda Velasco, Instituto Valenciano de Oncologia, Valencia; Javier M. Broto, Hospital Universitari Son Espases, Palma de Mallorca, Spain; Dusan Kotasek, Adelaide Cancer Centre, Kurralta Park, and University of Adelaide, Adelaide, South Australia; David Goldstein, Prince of Wales Hospital, New South Wales, Sydney; John R. Zalcberg, Peter MacCallum Cancer Institute, East Melbourne, Victoria, Australia; Piotr Rutkowski, Maria Sklodowska-Curie Memorial Cancer Centre and Institute of Oncology, Warsaw, Poland; Peter Hohenberger, Mannheim University Medical Center, Mannheim; Jörg T. Hartmann, Christian-Albrechts University, Kiel, Germany; Ian R. Judson, Royal Marsden Hospital; Winette T.A. van der Graaf, The Institute of Cancer Research and the Royal Marsden NHS Foundation Trust, London, United Kingdom; Hans Gelderblom, Leiden University Medical Center, Leiden; Winette T.A. van der Graaf, Radboud University Medical Center, Nijmegen, the Netherlands; Saskia Litière, and Sandrine Marréaud, European Organisation for Research and Treatment of Cancer, Brussels, Belgium.

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http://jco.ascopubs.org/content/early/2015/11/16/JCO.2015.62
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http://jco.ascopubs.org/cgi/doi/10.1200/JCO.2015.62.4304
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http://dx.doi.org/10.1200/JCO.2015.62.4304DOI Listing
December 2015

Paclitaxel Given Once Per Week With or Without Bevacizumab in Patients With Advanced Angiosarcoma: A Randomized Phase II Trial.

J Clin Oncol 2015 Sep 27;33(25):2797-802. Epub 2015 Jul 27.

Isabelle L. Ray-Coquard, Philippe A. Cassier, and Jean-Yves Blay, Centre Léon Bérard and Claude Bernard University, Lyon; Julien Domont, Olivier Mir, and Axel Le Cesne, Gustave Roussy, Villejuif; Emmanuelle Tresch-Bruneel and Stéphanie Clisant, Centre Oscar Lambret; Nicolas Penel, Centre Oscar Lambret and Lille-Nord-de-France Medical School, Lille; Emmanuelle Bompas, Centre René Gauducheau, Nantes; Sophie Piperno-Neumann, Institut Curie, Paris; Antoine Italiano, Institut Bergonié, Bordeaux; Christine Chevreau, Institut Claudius Regaud, Toulouse; Didier Cupissol, Institut de Cancérologie de Montpellier, Val d'Aurelle, Montpellier; François Bertucci, Institut Paoli Calmette, Marseille; Jacques-Olivier Bay, Centre Jean Perrin, Clermont-Ferrand; Olivier Collard, Institut de Cancérologie de la Loire Lucien Neuwirth, Saint Priest en Jarez; Esma Saada-Bouzid, Centre Antoine Lacassagne, Nice; Nicolas Isambert, Centre Georges-François Leclerc, Dijon; and Corinne Delcambre, Centre François Baclesse, Caen, France.

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http://dx.doi.org/10.1200/JCO.2015.60.8505DOI Listing
September 2015

Trabectedin in advanced synovial sarcomas: a multicenter retrospective study from four European institutions and the Italian Rare Cancer Network.

Anticancer Drugs 2015 Jul;26(6):678-81

aAdult Mesenchymal Tumor Medical Oncology Unit, Department of Cancer Medicine, Fondazione IRCCS Istituto Nazionale Tumori, Milan bDepartment of Oncology, General Hospital of Agrigento, Agrigento cDepartment of Oncology, Ospedale Civile SS Annunziata Sassari, Sassari dMedical Oncology Unit, University Hospital S. Chiara, Pisa eDepartment of Anatomic Pathology, General Hospital of Treviso, Treviso, Italy fDepartment of Oncology, University College of London Hospital gSarcoma Unit, Royal Marsden, London, UK hCentre Leon Berard, Lyon iInstitut Gustave Roussy, Villejuif, France.

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http://dx.doi.org/10.1097/CAD.0000000000000228DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4730787PMC
July 2015

Algorithm for the surgical management of mesenchymal tumors of the perineum in adults.

Dis Colon Rectum 2015 Mar;58(3):304-13

1 Department of Surgical Oncology, Institut Gustave Roussy, Villejuif, France 2 Department of Radiology, Institut Gustave Roussy, Villejuif, France 3 Department of Pathology, Institut Gustave Roussy, Villejuif, France 4 Department of Medical Oncology, Institut Gustave Roussy, Villejuif, France 5 Department of Radiotherapy, Institut Gustave Roussy, Villejuif, France.

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http://dx.doi.org/10.1097/DCR.0000000000000272DOI Listing
March 2015

Desmoid-type fibromatosis and pregnancy: a multi-institutional analysis of recurrence and obstetric risk.

Ann Surg 2014 May;259(5):973-8

*Department of Surgery, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy †Department of Surgery, Institut Gustave Roussy, Villejuif, France ‡Division of General Surgery, Mount Sinai Hospital; Department of Surgical Oncology, Princess Margaret Hospital; and Department of Surgery, University of Toronto, Toronto, Ontario, Canada §Department of Surgery, Brigham and Women's Hospital, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA ¶Department of Medical Oncology, Brigham and Women's Hospital, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA ‖Department of Medical Oncology, Institut Gustave Roussy, Villejuif, France **Department of Medical Oncology, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy.

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http://pdfs.journals.lww.com/annalsofsurgery/2014/05000/Desm
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http://content.wkhealth.com/linkback/openurl?sid=WKPTLP:land
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http://dx.doi.org/10.1097/SLA.0000000000000224DOI Listing
May 2014

Efficacy and safety of trabectedin as an early treatment for advanced or metastatic liposarcoma and leiomyosarcoma.

Future Oncol 2014 Jan 29;10(1):59-68. Epub 2013 Aug 29.

Department of Medicine, Centre Leon Berard, 28 rue Laennec, 69008 Lyon, France.

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http://dx.doi.org/10.2217/fon.13.163DOI Listing
January 2014

Epithelioid sarcoma: need for a multimodal approach to maximize the chances of curative conservative treatment.

Ann Surg Oncol 2014 Jan 18;21(1):269-76. Epub 2013 Sep 18.

Department of Radiation Oncology, Institut Gustave-Roussy, Université Paris Sud, Villejuif, France,

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http://dx.doi.org/10.1245/s10434-013-3247-4DOI Listing
January 2014

CTNNB1 45F mutation is a molecular prognosticator of increased postoperative primary desmoid tumor recurrence: an independent, multicenter validation study.

Cancer 2013 Oct 31;119(20):3696-702. Epub 2013 Jul 31.

Sarcoma Service, Department of Surgery, Scientific Institute for Research, Hospitalization, and Health Care (IRCCS) Foundation, National Cancer Institute, Milan, Italy.

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http://dx.doi.org/10.1002/cncr.28271DOI Listing
October 2013