Axel Grothey

Axel Grothey

UNVERIFIED PROFILE

Are you Axel Grothey?   Register this Author

Register author
Axel Grothey

Axel Grothey

Publications by authors named "Axel Grothey"

Are you Axel Grothey?   Register this Author

100Publications

2168Reads

17Profile Views

Echocardiographic Assessment for the Detection of Cardiotoxicity Due to Vascular Endothelial Growth Factor Inhibitor Therapy in Metastatic Renal Cell and Colorectal Cancers.

J Am Soc Echocardiogr 2019 Feb 17;32(2):267-276. Epub 2018 Nov 17.

Department of Cardiovascular Medicine, Mayo Clinic, Rochester, Minnesota; Division of Cardiology, Department of Medicine, Dalhousie University, Halifax, Nova Scotia, Canada. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.echo.2018.09.019DOI Listing
February 2019

Case series of dabrafenib-trametinib-induced pyrexia successfully treated with colchicine.

Support Care Cancer 2019 Feb 14. Epub 2019 Feb 14.

Department of Oncology, Mayo Clinic, 200 First Street SW, Rochester, MN, 55905, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s00520-019-4654-2DOI Listing
February 2019

Impact of primary tumour location on efficacy of bevacizumab plus chemotherapy in metastatic colorectal cancer.

Br J Cancer 2018 Dec 29;119(12):1451-1455. Epub 2018 Nov 29.

University of Southern California, Norris Comprehensive Cancer Center, Keck School of Medicine, 1441 Eastlake Ave, Los Angeles, CA, 90033, USA.

View Article

Download full-text PDF

Source
http://www.nature.com/articles/s41416-018-0304-6
Publisher Site
http://dx.doi.org/10.1038/s41416-018-0304-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6288128PMC
December 2018

Circulating Tumor DNA-Defined Minimal Residual Disease in Solid Tumors: Opportunities to Accelerate the Development of Adjuvant Therapies.

J Clin Oncol 2018 Oct 30:JCO2018789032. Epub 2018 Oct 30.

Arvind Dasari, The University of Texas MD Anderson Cancer Center, Houston, TX; Axel Grothey, The University of Tennessee West Cancer Center, Memphis, TN; and Scott Kopetz, The University of Texas MD Anderson Cancer Center, Houston, TX.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1200/JCO.2018.78.9032DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6286158PMC
October 2018

Duration of Adjuvant Chemotherapy for Stage III Colon Cancer.

N Engl J Med 2018 07;379(4):396-397

Mayo Clinic, Rochester MN

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1056/NEJMc1805498DOI Listing
July 2018

Leptomeningeal Carcinomatosis in Colorectal Cancer: The Mayo Clinic Experience.

Clin Colorectal Cancer 2018 06 21;17(2):e183-e187. Epub 2017 Nov 21.

Division of Medical Oncology, Mayo Clinic Rochester, Rochester, MN.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.clcc.2017.11.003DOI Listing
June 2018

5-fluorouracil and cardiotoxicity: a review.

Ther Adv Med Oncol 2018 18;10:1758835918780140. Epub 2018 Jun 18.

Department of Medical Oncology, Mayo College of Medicine, Rochester, MN, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1177/1758835918780140DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6024329PMC
June 2018

Chemotherapy-Induced Neutropenia as a Prognostic and Predictive Marker of Outcomes in Solid-Tumor Patients.

Drugs 2018 May;78(7):737-745

Division of Medical Oncology, College of Medicine/Oncology, Mayo Clinic, Gonda 10, 200 First St SW, Rochester, MN, 55905, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s40265-018-0909-3DOI Listing
May 2018

Optimizing Adjuvant Therapy for Localized Colon Cancer and Treatment Selection in Advanced Colorectal Cancer.

J Natl Compr Canc Netw 2018 May;16(5S):611-615

Presented by Axel Grothey, MD, Mayo Clinic Cancer Center, Phoenix, Arizona, and Alan P. Venook, MD, University of California, San Francisco, San Francisco, California.

View Article

Download full-text PDF

Source
http://www.jnccn.org/lookup/doi/10.6004/jnccn.2018.0038
Publisher Site
http://dx.doi.org/10.6004/jnccn.2018.0038DOI Listing
May 2018

Duration of Adjuvant Chemotherapy for Stage III Colon Cancer.

N Engl J Med 2018 Mar;378(13):1177-1188

From the Divisions of Medical Oncology (A.G.) and Biomedical Statistics and Informatics (Q.S., J.P.M., L.A.R., D.J.S.), Mayo Clinic, Rochester, MN; Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS) San Martino-IST, Genoa (A.F. Sobrero), Ospedale Papa Giovanni XXIII, Bergamo (R.L.), and IRCCS Mario Negri Institute for Pharmacological Research, Milan (V.T.) - all in Italy; Karmanos Cancer Institute, Wayne State University, Detroit (A.F. Shields); National Cancer Center Hospital East, Chiba (T. Yoshino), Yokohama City University School of Medicine, Yokohama (T. Yamanaka), and the University of Tokyo, Tokyo (T.W.) - all in Japan; the Institute of Cancer Sciences, University of Glasgow, Glasgow (J.P.), the University of Oxford, Oxford (R.K.), Christie Hospital, Manchester (M.S.), and University Hospital Southampton, Southampton (T.I.) - all in the United Kingdom; Hôpital Européen Georges-Pompidou, Sorbonne Paris Cite/Paris Descartes University (J.T.), and Saint-Antoine Hospital and Sorbonne Universités, Pierre and Marie Curie University-Paris 6 (T.A.), Paris, and Methodology and Quality of Life Unit, INSERM Unité 1098, Besançon (D.V.) - all in France; the Department of Medical Oncology, University Hospital of Heraklion, Faculty of Medicine, University of Crete, Heraklion (J.S.), and Bioclinic Thessaloniki, Thessaloniki (I.B.) - both in Greece; Dana-Farber Cancer Institute, Boston (J.A.M.); and Duke Cancer Institute, Durham, NC (D.N.).

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1056/NEJMoa1713709DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6426127PMC
March 2018

Highlights in metastatic colorectal cancer from the 2018 American Society of Clinical Oncology Gastrointestinal Cancers Symposium: commentary.

Authors:
Axel Grothey

Clin Adv Hematol Oncol 2018 Mar;16 Suppl 6(3):20-23

Mayo Clinic, Rochester, Minnesota.

View Article

Download full-text PDF

Source
March 2018

Continued disappointments with targeted agents in first-line therapy of advanced gastric cancers.

Lancet Oncol 2017 11 25;18(11):1427-1428. Epub 2017 Sep 25.

Division of Medical Oncology, Mayo Clinic, Rochester, MN 55905, USA. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/S1470-2045(17)30714-3DOI Listing
November 2017

BRAF Mutations Define a Clinically Distinct Molecular Subtype of Metastatic Colorectal Cancer.

J Clin Oncol 2017 Aug 9;35(23):2624-2630. Epub 2017 May 9.

Jeremy C. Jones, Lindsay A. Renfro, Ben Y. Zhang, Pashtoon M. Kasi, Jesse S. Voss, Alexis D. Leal, Joleen M. Hubbard, Benjamin R. Kipp, Robert R. McWilliams, and Axel Grothey, Mayo Clinic, Rochester, MN; Humaid O. Al-Shamsi, Scott Kopetz, and Robert A. Wolff, The University of Texas MD Anderson Cancer Center, Houston, TX; and Alexa B. Schrock, Andrew Rankin, James Sun, Jeffrey Ross, and Siraj M. Ali, Foundation Medicine, Cambridge, MA.

View Article

Download full-text PDF

Source
http://ascopubs.org/doi/10.1200/JCO.2016.71.4394
Publisher Site
http://dx.doi.org/10.1200/JCO.2016.71.4394DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5549454PMC
August 2017

Evidence in Favor of Standard Surgical Treatment for Rectal Cancer.

JAMA Oncol 2017 07;3(7):885-886

Division of Medical Oncology, Mayo Clinic, Rochester, Minnesota.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1001/jamaoncol.2016.5397DOI Listing
July 2017

Napabucasin: An Update on the First-in-Class Cancer Stemness Inhibitor.

Drugs 2017 Jul;77(10):1091-1103

Department of Medical Oncology, Mayo Clinic Rochester, 200 First Street NW, Rochester, MN, 55905, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s40265-017-0759-4DOI Listing
July 2017

Lack of Caudal-Type Homeobox Transcription Factor 2 Expression as a Prognostic Biomarker in Metastatic Colorectal Cancer.

Clin Colorectal Cancer 2017 06 17;16(2):124-128. Epub 2016 Sep 17.

Department of Oncology, Mayo Clinic, Rochester, MN. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.clcc.2016.09.003DOI Listing
June 2017

Clinical Calculator for Early Mortality in Metastatic Colorectal Cancer: An Analysis of Patients From 28 Clinical Trials in the Aide et Recherche en Cancérologie Digestive Database.

J Clin Oncol 2017 Jun 17;35(17):1929-1937. Epub 2017 Apr 17.

Lindsay A. Renfro, Axel Grothey, and Daniel J. Sargent, Mayo Clinic, Rochester, MN; Richard M. Goldberg, The Ohio State University, Columbus, OH; Alberto Sobrero, Ospedale San Martino, Genoa; Alfredo Falcone, University Hospital of Pisa, Pisa, Italy; Richard Adams, Cardiff University, Cardiff; Matthew T. Seymour, St James's Hospital and University of Leeds, Leeds, United Kingdom; Volker Heinemann, University of Munich, Munich; Hans-Joachim Schmoll, University Clinic Halle (Saale), Halle; Rainer Porschen, Klinikum Bremen-Ost Klinik für Innere Medizin, Bremen; Carsten Bokemeyer, University Hospital, Hamburg-Eppendorf, Germany; Jean-Yves Douillard, Centre René Gauducheau, Nantes; Christophe Tournigand, University of Paris Est Creteil; Christophe Tournigand, Assistance Hopitaux Publique de Paris Henri-Mondor Hospital, Créteil; Benoist Chibaudel and Aimery de Gramont, Franco-British Institute, Levallois-Perret, France; Herbert Hurwitz, Duke University Medical Center, Durham, NC; Charles S. Fuchs; Dana-Farber Cancer Institute, Boston, MA; Eduardo Diaz-Rubio, Hospital Clínico San Carlos, Universidad Complutense, Instituto de Investigación Sanitaria del Hospital Clínico San Carlos, Madrid, Spain; Paulo M. Hoff, Hospital Sírio-Libanês and University of São Paulo, São Paulo, Brazil; Fairooz F. Kabbinavar and J. Randolph Hecht, David Geffen School of Medicine at University of California at Los Angeles, Los Angeles, CA; Niall C. Tebbutt, Austin Health, Heidelberg, Victoria, Australia; Cornelis J.A. Punt, University of Amsterdam, Amsterdam, the Netherlands; John Souglakos, University of Crete, Heraklion, Greece; Eric Van Cutsem, University Hospital Leuven, Leuven, Belgium; and Leonard Saltz, Memorial Sloan Kettering Cancer Center, New York, NY.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1200/JCO.2016.71.5771DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5466009PMC
June 2017

Antiangiogenic therapy for refractory colorectal cancer: current options and future strategies.

Ther Adv Med Oncol 2017 Feb 10;9(2):106-126. Epub 2016 Nov 10.

Mayo Clinic, Rochester, MN, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1177/1758834016676703DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5298403PMC
February 2017

Chemotherapy Maintenance.

Cancer J 2016 May-Jun;22(3):199-204

From the *Hematology/Oncology and †Division of Medical Oncology, Mayo Clinic, Rochester, MN.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1097/PPO.0000000000000195DOI Listing
January 2017

European Society for Medical Oncology Copenhagen update: potential practice-changing findings.

Ther Adv Med Oncol 2017 Jan 29;9(1):4-12. Epub 2016 Dec 29.

Mayo Clinic, Rochester, MN, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1177/1758834016679105DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5298453PMC
January 2017

Role of Biologics in First-Line Treatment of Colorectal Cancer.

J Oncol Pract 2016 12;12(12):1219-1228

Mayo Clinic, Rochester, MN.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1200/JOP.2016.018382DOI Listing
December 2016

Further Evaluating the Benefit of Adjuvant Chemotherapy for Colon Cancer.

J Clin Oncol 2016 Oct;34(30):3711-3712

Mayo Clinic, Rochester, MN.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1200/JCO.2016.68.4886DOI Listing
October 2016

Adjuvant Therapy for Colon Cancer: Small Steps Toward Precision Medicine.

JAMA Oncol 2016 Sep;2(9):1133-4

Division of Biomedical Statistics and Informatics, Mayo Clinic, Rochester, Minnesota.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1001/jamaoncol.2016.2304DOI Listing
September 2016

ESMO / ASCO Recommendations for a Global Curriculum in Medical Oncology Edition 2016.

Authors:
Christian Dittrich Michael Kosty Svetlana Jezdic Doug Pyle Rossana Berardi Jonas Bergh Nagi El-Saghir Jean-Pierre Lotz Pia Österlund Nicholas Pavlidis Gunta Purkalne Ahmad Awada Susana Banerjee Smita Bhatia Jan Bogaerts Jan Buckner Fatima Cardoso Paolo Casali Edward Chu Julia Lee Close Bertrand Coiffier Roisin Connolly Sarah Coupland Luigi De Petris Maria De Santis Elisabeth G E de Vries Don S Dizon Jennifer Duff Linda R Duska Alexandru Eniu Marc Ernstoff Enriqueta Felip Martin F Fey Jill Gilbert Nicolas Girard Andor W J M Glaudemans Priya K Gopalan Axel Grothey Stephen M Hahn Diana Hanna Christian Herold Jørn Herrstedt Krisztian Homicsko Dennie V Jones Lorenz Jost Ulrich Keilholz Saad Khan Alexander Kiss Claus-Henning Köhne Rainer Kunstfeld Heinz-Josef Lenz Stuart Lichtman Lisa Licitra Thomas Lion Saskia Litière Lifang Liu Patrick J Loehrer Merry Jennifer Markham Ben Markman Marius Mayerhoefer Johannes G Meran Olivier Michielin Elizabeth Charlotte Moser Giannis Mountzios Timothy Moynihan Torsten Nielsen Yuichiro Ohe Kjell Öberg Antonio Palumbo Fedro Alessandro Peccatori Michael Pfeilstöcker Chandrajit Raut Scot C Remick Mark Robson Piotr Rutkowski Roberto Salgado Lidia Schapira Eva Schernhammer Martin Schlumberger Hans-Joachim Schmoll Lowell Schnipper Cristiana Sessa Charles L Shapiro Julie Steele Cora N Sternberg Friedrich Stiefel Florian Strasser Roger Stupp Richard Sullivan Josep Tabernero Luzia Travado Marcel Verheij Emile Voest Everett Vokes Jamie Von Roenn Jeffrey S Weber Hans Wildiers Yosef Yarden

ESMO Open 2016 29;1(5):e000097. Epub 2016 Sep 29.

Department of General Medical Oncology , University Hospitals Leuven , Leuven , Belgium.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1136/esmoopen-2016-000097DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5070299PMC
September 2016

Is obesity an advantage in patients with colorectal cancer?

Expert Rev Gastroenterol Hepatol 2015 14;9(11):1339-42. Epub 2015 Sep 14.

a 1 Division of Medical Oncology, Mayo Clinic, Rochester, MN, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1586/17474124.2015.1089170DOI Listing
August 2016

Therapy: Colorectal cancer: how to teach an old drug new tricks.

Nat Rev Gastroenterol Hepatol 2016 07 25;13(7):384-5. Epub 2016 May 25.

Department of Surgical Oncology and Department of Molecular and Cellular Oncology, University of Texas MD Anderson Cancer Center, Houston, Texas 77230-1402, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/nrgastro.2016.87DOI Listing
July 2016

Adverse event development in clinical oncology trials - Authors' reply.

Lancet Oncol 2016 07;17(7):e264-e265

Division of Medical Oncology, Mayo Clinic, Rochester, MN 55905, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/S1470-2045(16)30245-5DOI Listing
July 2016

Regorafenib in the treatment of colorectal cancer.

Expert Opin Pharmacother 2016 4;17(1):137-45. Epub 2015 Dec 4.

b Department of Medical Oncology , Mayo Clinic , Rochester , MN 55905 , USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1517/14656566.2016.1118054DOI Listing
June 2016

Determinants of Early Mortality Among 37,568 Patients With Colon Cancer Who Participated in 25 Clinical Trials From the Adjuvant Colon Cancer Endpoints Database.

J Clin Oncol 2016 Apr 8;34(11):1182-9. Epub 2016 Feb 8.

Winson Y. Cheung, British Columbia Cancer Agency, Vancouver, British Columbia; Chris O'Callaghan, Queen's University, Kingston, Ontario, Canada; Lindsay A. Renfro, Axel Grothey, Steven R. Alberts, and Daniel J. Sargent, Mayo Clinic, Rochester, MN; David Kerr, University of Oxford, Oxford; Chris Twelves, University of Leeds and St James Institute of Oncology, Leeds, United Kingdom; Aimery de Gramont, Franco-British Institute, Levallois-Perret; Thierry Andre, Hospital Saint-Antoine and Pierre and Marie Curie University, Paris; Jean-Francois Seitz, La Timone Hospital, Aix-Marseille University, Marseille, France; Leonard B. Saltz, Memorial Sloan Kettering Cancer Center, New York, NY; Katherine A. Guthrie, Fred Hutchinson Cancer Center, Seattle, WA; Roberto Labianca, Ospedale Giovanni XXIII, Bergamo; Guido Francini, University of Siena, Siena, Italy; Eric Van Cutsem, University Hospital Leuven, Leuven, Belgium; Daniel G. Haller, University of Pennsylvania, Philadelphia; and Greg Yothers, University of Pittsburgh, Pittsburgh, PA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1200/JCO.2015.65.1158DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4933130PMC
April 2016

Association between DPYD c.1129-5923 C>G/hapB3 and severe toxicity to 5-fluorouracil-based chemotherapy in stage III colon cancer patients: NCCTG N0147 (Alliance).

Pharmacogenet Genomics 2016 Mar;26(3):133-7

aDepartment of Molecular Pharmacology and Experimental Therapeutics (MPET), Mayo Clinic Cancer Center bAlliance Statistics and Data Center cDivision of Medical Oncology dDivision of Gastroenterology, Mayo Clinic, Rochester, Minnesota eDepartment of Surgery, Cancer Prevention and Control Program, University of Hawaii Cancer Center, Honolulu, Hawaii fDepartment of Medicine, Center for GI Oncology, The University of Chicago Medicine, Chicago, Illinois gDivision of Hematology Oncology, Vanderbilt-Ingram Cancer Center, Nashville, Tennessee hSurgical Oncology Associates of South Texas, San Antonio, Texas iDepartment of Hematology Oncology, Lehigh Valley Health Network, John and Dorthy Morgan Cancer Center, Allentown, Pennsylvania jDepartment of Oncology, Barbara Ann Karmanos Cancer Institute, Wayne State University, Detroit, Michigan kDepartment of Hematology/Oncology, Division of Medical Oncology, The Ohio State University Medical Center, Columbus, Ohio, USA lDepartment of Medicine, Division of Medical Oncology, University of British Columbia, British Columbia Cancer Agency, Vancouver, British Columbia, Canada.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1097/FPC.0000000000000197DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4738010PMC
March 2016

Current Options for Third-Line Treatment of Metastatic Colorectal Cancer.

Clin Adv Hematol Oncol 2016 Mar;14(3 Suppl 3):1-15

University of California Irvine, Irvine, California.

View Article

Download full-text PDF

Source
March 2016

Adjuvant Therapy After Resection of Metastatic Colorectal Cancer: Clear Proof of Principle in This Setting.

Oncology (Williston Park) 2016 Jan;30(1):50-1, 53

View Article

Download full-text PDF

Source
January 2016

Evaluating Continuous Tumor Measurement-Based Metrics as Phase II Endpoints for Predicting Overall Survival.

J Natl Cancer Inst 2015 Nov 21;107(11). Epub 2015 Aug 21.

Department of Mathematics, Vassar College, Poughkeepsie, NY (MWA); Department of Biostatistics, Analytical Science, Takeda Pharmaceuticals, Deerfield, IL (XD); Department of Health Sciences Research, Mayo Clinic, Rochester, MN (JM, DJS, SJM); Biometrics and Data Management Department, Novartis Pharmaceuticals Corporation, East Hanover, NJ (YH); Department of Oncology, Mayo Clinic, Rochester, MN (AG); European Organisation for Research and Treatment of Cancer (EORTC), Brussels, Belgium (JB).

View Article

Download full-text PDF

Source
http://jnci.oxfordjournals.org/content/107/11/djv239.full.pd
Web Search
http://jnci.oxfordjournals.org/lookup/doi/10.1093/jnci/djv23
Publisher Site
http://dx.doi.org/10.1093/jnci/djv239DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4643633PMC
November 2015

The Imperative for a New Approach to Toxicity Analysis in Oncology Clinical Trials.

J Natl Cancer Inst 2015 Oct 1;107(10). Epub 2015 Aug 1.

Department of Medical Oncology (GT, JH, AG) and Alliance Statistics and Data Center (JAS), Mayo Clinic, Rochester, MN.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1093/jnci/djv216DOI Listing
October 2015

Clinical Course of Oxaliplatin-Induced Neuropathy: Results From the Randomized Phase III Trial N08CB (Alliance).

J Clin Oncol 2015 Oct 17;33(30):3416-22. Epub 2015 Aug 17.

Deirdre R. Pachman, Rui Qin, Drew K. Seisler, Andreas S. Beutler, Lauren E. Ta, Jacqueline M. Lafky, Kathryn J. Ruddy, Nathan P. Staff, Axel Grothey, and Charles L. Loprinzi, Mayo Clinic, Rochester, MN; Ellen M.L. Smith, University of Michigan, Ann Arbor, MI; Nina D. Wagner-Johnston, Washington University School of Medicine, Saint Louis, MO; and Shaker Dakhil, Cancer Center of Kansas, Wichita, KS.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1200/JCO.2014.58.8533DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4606060PMC
October 2015

Molecular profiling in the treatment of colorectal cancer: focus on regorafenib.

Onco Targets Ther 2015 15;8:2949-57. Epub 2015 Oct 15.

Department of Medical Oncology, Mayo Clinic, Rochester, MN, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.2147/OTT.S79145DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4610887PMC
October 2015

Calcium and Magnesium Use for Oxaliplatin-Induced Neuropathy: A Case Study to Assess How Quickly Evidence Translates Into Practice.

J Natl Compr Canc Netw 2015 Sep;13(9):1097-101

From the Department of Oncology, Robert D. and Patricia E. Kern Center for the Science of Health Care Delivery, and Health Care Policy & Research, Mayo Clinic, Rochester, Minnesota; and Optum Labs, Cambridge, Massachusetts.

View Article

Download full-text PDF

Source
September 2015

Introduction to special issue on biomarker-based clinical trial designs in oncology.

Chin Clin Oncol 2015 Sep;4(3):28

Division of Medical Oncology, Mayo Clinic, Rochester, MN, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3978/j.issn.2304-3865.2015.09.05DOI Listing
September 2015

Maintenance therapy in the treatment of metastatic colorectal cancer. Axel Grothey, MD.

Authors:
Axel Grothey

Oncology (Williston Park) 2015 Aug;29(8):560, 594

View Article

Download full-text PDF

Source
August 2015

Regorafenib in metastatic colorectal cancer: optimal dosing and patient selection recommendations.

Authors:
Axel Grothey

Clin Adv Hematol Oncol 2015 Aug;13(8):514-7

May Clinic, Rochester, Minnesota.

View Article

Download full-text PDF

Source
August 2015

Randomized phase III trial of regorafenib in metastatic colorectal cancer: analysis of the CORRECT Japanese and non-Japanese subpopulations.

Invest New Drugs 2015 Jun 12;33(3):740-50. Epub 2014 Sep 12.

Department of Gastroenterology and Gastrointestinal Oncology, National Cancer Center Hospital East, 6-5-1, Kashiwanoha, Kashiwa, 277-8577, Chiba, Japan,

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s10637-014-0154-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4434855PMC
June 2015

Gastrointestinal cancer: Rationale for metronomic chemotherapy in phase III trials.

Nat Rev Clin Oncol 2015 Jun 12;12(6):313-4. Epub 2015 May 12.

Division of Biomedical Statistics and Informatics, Mayo Clinic, 200 First Street SW, Rochester, MN 55905, USA.

View Article

Download full-text PDF

Source
http://www.nature.com/articles/nrclinonc.2015.89
Publisher Site
http://dx.doi.org/10.1038/nrclinonc.2015.89DOI Listing
June 2015

The role of regorafenib in metastatic colorectal cancer.

Lancet Oncol 2015 Jun 13;16(6):596-7. Epub 2015 May 13.

Division of Medical Oncology, Mayo Clinic, Rochester, MN, USA. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/S1470-2045(15)70191-9DOI Listing
June 2015

Rectal Cancer, Version 2.2015.

J Natl Compr Canc Netw 2015 Jun;13(6):719-28; quiz 728

Robert H. Lurie Comprehensive Cancer Center of Northwestern University; UCSF Helen Diller Family Comprehensive Cancer Center; The Ohio State University Comprehensive Cancer Center - James Cancer Hospital and Solove Research Institute; Vanderbilt-Ingram Cancer Center; City of Hope Comprehensive Cancer Center; Fox Chase Cancer Center; Dana-Farber/Brigham and Women's Cancer Center; St. Jude Children's Research Hospital/The University of Tennessee Health Science Center; Fred & Pamela Buffett Cancer Center; Mayo Clinic Cancer Center; Yale Cancer Center/Smilow Cancer Hospital; Siteman Cancer Center at Barnes-Jewish Hospital and Washington University School of Medicine; University of Alabama at Birmingham Comprehensive Cancer Center; Stanford Cancer Institute; Fred Hutchinson Cancer Research Center/Seattle Cancer Care Alliance; University of Colorado Cancer Center; UC San Diego Moores Cancer Center; Roswell Park Cancer Institute; The University of Texas MD Anderson Cancer Center; Massachusetts General Hospital Cancer Center; Memorial Sloan Kettering Cancer Center; Huntsman Cancer Institute at the University of Utah; Moffitt Cancer Center; University of Michigan Comprehensive Cancer Center; The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins; Duke Cancer Institute; and National Comprehensive Cancer Network.

View Article

Download full-text PDF

Source
June 2015

When less is more: maintenance therapy in colorectal cancer.

Lancet 2015 May 7;385(9980):1808-10. Epub 2015 Apr 7.

Division of Medical Oncology, Mayo Clinic Rochester, Rochester, MN 55905, USA. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/S0140-6736(14)62350-3DOI Listing
May 2015

Optimizing systemic therapy selection in metastatic colorectal cancer.

Authors:
Axel Grothey

J Natl Compr Canc Netw 2015 May;13(5 Suppl):682-5

Presented by Axel Grothey, MD, Professor of Oncology, Mayo Clinic, Rochester, Minnesota.

View Article

Download full-text PDF

Source
May 2015

Metastatic extramammary Paget's disease responding to weekly paclitaxel.

BMJ Case Rep 2015 Apr 22;2015. Epub 2015 Apr 22.

Department of Oncology, Mayo Clinic, Rochester, Minnesota, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1136/bcr-2014-208653DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4420812PMC
April 2015

Selection of biologics for patients with metastatic colorectal cancer: the role of predictive markers.

Expert Rev Gastroenterol Hepatol 2015 Mar 12;9(3):273-6. Epub 2015 Jan 12.

Division of Medical Oncology, Mayo Clinic, 200 First St SW, Rochester, MN, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1586/17474124.2015.1001743DOI Listing
March 2015

Colorectal cancer in 2014: progress in defining first-line and maintenance therapies.

Nat Rev Clin Oncol 2015 Feb 6;12(2):73-4. Epub 2015 Jan 6.

Division of Medical Oncology, Mayo Clinic, 200 First Street SW, Rochester, MN 55905, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/nrclinonc.2014.233DOI Listing
February 2015

Individual patient data analysis of progression-free survival versus overall survival as a first-line end point for metastatic colorectal cancer in modern randomized trials: findings from the analysis and research in cancers of the digestive system database.

J Clin Oncol 2015 Jan 10;33(1):22-8. Epub 2014 Nov 10.

Qian Shi, Axel Grothey, and Daniel J. Sargent, Mayo Clinic, Rochester, MN; Aimery de Gramont and Benoist Chibaudel, Hospital Saint Antoine; Christophe Tournigand, Université Paris Est Créteil, Paris; Jean-Yves Douillard, Institute of Cancer Research in Western, St Herblain, France; John Zalcberg, Monash University; Niall C. Tebbutt, Austin Health, Melbourne, Victoria, Australia; Hans-Joachim Schmoll, Martin-Luther University, Halle; Rainer Porschen, Klinikum Bremen-Ost, Bremen; Volker Heinemann, University of Munich, München; Carsten Bokemeyer, University Hospital, Hamburg-Eppendorf, Germany; Matthew T. Seymour, Cancer Research UK Clincal Center, Leeds; Richard Adams, Cardiff University, Cardiff, United Kingdom; Leonard Saltz, Memorial Sloan-Kettering Cancer Center, New York, NY; Richard M. Goldberg, Ohio State University, Columbus, OH; Cornelis J.A. Punt, Academic Medical Center, Amsterdam, the Netherlands; Paulo M. Hoff, Hospital Sírio-Libanês, Sao Paulo, Brazil; Joel Randolph Hecht and Fairooz F. Kabbinavar, University of California at Los Angeles, Los Angeles, CA; Herbert Hurwitz, Duke University, Durham, NC; Eduardo Díaz-Rubio, Hospital Clinico San Carlos, Madrid, Spain; Charles Fuchs, Dana-Farber Cancer Institute, Boston, MA; John Souglakos, University of Crete, Heraklion, Greece; Alfredo Falcone, University of Pisa, Pisa, Italy; Eric Van Cutsem, University Hospital Gasthuisberg, Leuven; and Marc Buyse, International Drug Development Institute, Louvain-la-Neuve, Belgium.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1200/JCO.2014.56.5887DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4482837PMC
January 2015

ACCENT-based web calculators to predict recurrence and overall survival in stage III colon cancer.

J Natl Cancer Inst 2014 Dec 29;106(12). Epub 2014 Oct 29.

Division of Biomedical Statistics and Informatics, Mayo Clinic, Rochester, MN (LAR, DJS); Department of Oncology, Mayo Clinic, Rochester, MN (AMG, SRA, CLL); Department of Statistics, University of Virginia, Charlottesville, VA (YX); Gastrointestinal Oncology Service, Memorial Sloan-Kettering Cancer Center, New York, NY (LBS); Hôpital Saint Antoine, Paris, France; Pierre and Marie Curie University, Paris, France (TA); Leeds Institute of Cancer and Pathology, University of Leeds and St. James's University Hospital, Leeds Cancer Research UK Centre, UK (CT); Oncology Unit, Ospedale Giovanni XXIII, Bergamo, Italy (RL); Division of Hematology and Oncology, University of Florida, Gainesville, FL (CJA); National Surgical Adjuvant Breast and Bowel Project Biostatistical Center, Pittsburgh, PA (GY).

View Article

Download full-text PDF

Source
http://jnci.oxfordjournals.org/content/106/12/dju333.full.pd
Web Search
http://jnci.oxfordjournals.org/cgi/doi/10.1093/jnci/dju333
Publisher Site
http://dx.doi.org/10.1093/jnci/dju333DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4334801PMC
December 2014

Reply to C.d. Atkins and a. Avan et Al.

J Clin Oncol 2014 Oct 18;32(29):3342-3. Epub 2014 Aug 18.

Mayo Clinic, Rochester, MN.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1200/JCO.2014.57.2537DOI Listing
October 2014

Patient and tumor characteristics and BRAF and KRAS mutations in colon cancer, NCCTG/Alliance N0147.

J Natl Cancer Inst 2014 Jul 12;106(7). Epub 2014 Jun 12.

Affiliations of authors: Division of Hematology/Division of Medical Oncology (WIG), Division of Biomedical Statistics & Informatics (MRM, GDN), Cancer Center Statistics (DJS), Division of Medical Oncology (SRA, AG, JMH, RRM), Division of Gastroenterology & Hepatology/Division of Medical Oncology (FAS), Division of Gastroenterology & Hepatology (PJL), Molecular Genetics (SNT), Mayo Clinic, Rochester, MN; Department of Internal Medicine, Division of Medical Oncology, Ohio State University, Columbus, OH (RMG); Division of Hematology/Oncology, Vanderbilt University, Nashville, TN (EC); Section of Hematology/Medical Oncology, Lehigh Valley Health Network, Allentown, PA (SN); Cancer Prevention & Control Program, University of Hawaii Cancer Center, Honolulu, HI (JLB).

View Article

Download full-text PDF

Source
https://academic.oup.com/jnci/article-lookup/doi/10.1093/jnc
Publisher Site
http://dx.doi.org/10.1093/jnci/dju106DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4110470PMC
July 2014

Optimizing treatment outcomes with regorafenib: personalized dosing and other strategies to support patient care.

Oncologist 2014 Jun 12;19(6):669-80. Epub 2014 May 12.

Mayo Clinic, Rochester, Minnesota, USA; Dana-Farber Cancer Institute and Harvard Medical School, Boston, Massachusetts, USA; University Hospital Gasthuisberg/Leuven, Leuven, Belgium; Léon Bérard Centre and Claude Bernard University, Lyon, France; IRCCS San Martino, Genoa, Italy.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1634/theoncologist.2013-0059DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4041675PMC
June 2014

Evaluation of alternate categorical tumor metrics and cut points for response categorization using the RECIST 1.1 data warehouse.

J Clin Oncol 2014 Mar 10;32(8):841-50. Epub 2014 Feb 10.

Sumithra J. Mandrekar, Jeffrey Meyers, Axel Grothey, and Daniel J. Sargent, Mayo Clinic, Rochester, MN; Ming-Wen An, Vassar College, Poughkeepsie, NY; and Jan Bogaerts, European Organisation for Research and Treatment of Cancer, Brussels, Belgium.

View Article

Download full-text PDF

Source
http://ascopubs.org/doi/10.1200/JCO.2013.52.3019
Publisher Site
http://dx.doi.org/10.1200/JCO.2013.52.3019DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3940541PMC
March 2014

Adaptive randomized phase II design for biomarker threshold selection and independent evaluation.

Chin Clin Oncol 2014 Mar;3(1)

Division of Biomedical Statistics and Informatics, Mayo Clinic, Rochester, MN, USA.

View Article

Download full-text PDF

Source
http://www.thecco.net/article/view/3489/4336
Publisher Site
http://dx.doi.org/10.3978/j.issn.2304-3865.2013.12.04DOI Listing
March 2014

Colorectal cancer: how emerging molecular understanding affects treatment decisions.

Oncology (Williston Park) 2014 Feb;28(2):110-8

View Article

Download full-text PDF

Source
February 2014