Publications by authors named "Avrum Spira"

100Publications

Low oxygen saturation during sleep reduces CD1D and RAB20 expressions that are reversed by CPAP therapy.

EBioMedicine 2020 Jun 5;56:102803. Epub 2020 Jun 5.

Division of Sleep Medicine, Harvard Medical School, Boston, MA 02115, USA; Division of Sleep and Circadian Disorders, Department of Medicine, Brigham and Women's Hospital, Boston, MA, USA; Division of Pulmonary, Critical Care, and Sleep Medicine, Beth Israel Deaconess Medical Center, Boston, MA, USA; VA Boston Healthcare System, Boston, MA, USA.

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http://dx.doi.org/10.1016/j.ebiom.2020.102803DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7276515PMC
June 2020

Gene Expression Alterations in the Bronchial Epithelium of e-Cigarette Users.

Chest 2019 10 22;156(4):764-773. Epub 2019 Jun 22.

Bioinformatics Program, Boston University, Boston, MA; Section of Computational Biomedicine, Department of Medicine, Boston University School of Medicine, Boston, MA.

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http://dx.doi.org/10.1016/j.chest.2019.05.022DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6859252PMC
October 2019

Detection of early lung cancer among military personnel (DECAMP) consortium: study protocols.

BMC Pulm Med 2019 Mar 7;19(1):59. Epub 2019 Mar 7.

Division of Pulmonary, Allergy, and Critical Care Medicine, Boston University School of Medicine, Boston, MA, 02118, USA.

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http://dx.doi.org/10.1186/s12890-019-0825-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6407252PMC
March 2019

Biomarkers in Lung Cancer Screening: Achievements, Promises, and Challenges.

J Thorac Oncol 2019 03 4;14(3):343-357. Epub 2018 Dec 4.

Solid Tumors Program, Centro de Investigación Médica Aplicada, Pamplona, Spain; Navarra Institute for Health Research, Pamplona, Spain; CIBERONC, Centro de Investigación Biomédica en Red de Cáncer, Madrid, Spain; Department of Pathology, Anatomy and Physiology, School of Medicine, University of Navarra, Pamplona, Spain. Electronic address:

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http://dx.doi.org/10.1016/j.jtho.2018.11.023DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6494979PMC
March 2019

Electronic cigarettes: a task force report from the European Respiratory Society.

Eur Respir J 2019 02 31;53(2). Epub 2019 Jan 31.

Dept of Pathophysiology and Transplantation, Università degli Studi di Milano, Internal Medicine Department, Respiratory Unit and Regional Adult Cystic Fibrosis Center, IRCCS Fondazione Cà Granda Ospedale Maggiore Policlinico, Milan, Italy.

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http://dx.doi.org/10.1183/13993003.01151-2018DOI Listing
February 2019

microRNA-mRNA regulatory networks underlying chronic mucus hypersecretion in COPD.

Eur Respir J 2018 09 6;52(3). Epub 2018 Sep 6.

Dept of Pathology and Medical Biology, University of Groningen, University Medical Centre Groningen, Groningen, The Netherlands.

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http://dx.doi.org/10.1183/13993003.01556-2017DOI Listing
September 2018

Defining Impaired Respiratory Health. A Paradigm Shift for Pulmonary Medicine.

Am J Respir Crit Care Med 2018 08;198(4):440-446

1 Asthma and COPD Program, Division of Pulmonary and Critical Care Medicine, and.

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http://dx.doi.org/10.1164/rccm.201801-0120PPDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6118019PMC
August 2018

Impact of an Interdisciplinary Computational Research Section in a Department of Medicine: An 8-Year Perspective.

Am J Med 2018 07 27;131(7):846-851. Epub 2018 Mar 27.

Department of Medicine, Boston University School of Medicine, Mass.

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http://dx.doi.org/10.1016/j.amjmed.2018.03.008DOI Listing
July 2018

The Airway Transcriptome as a Biomarker for Early Lung Cancer Detection.

Clin Cancer Res 2018 07 20;24(13):2984-2992. Epub 2018 Feb 20.

Section of Computational Biomedicine, Department of Medicine and BU-BMC Cancer Center, Boston University, Boston, Massachusetts.

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http://dx.doi.org/10.1158/1078-0432.CCR-16-3187DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7397497PMC
July 2018

Impact of Chronic Obstructive Pulmonary Disease on Immune-based Treatment for Lung Cancer. Moving toward Disease Interception.

Am J Respir Crit Care Med 2018 02;197(3):278-280

2 Boston University Medical Center Boston, Massachusetts.

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http://dx.doi.org/10.1164/rccm.201710-2065EDDOI Listing
February 2018

subfamily suppression in lung cancer pathogenesis: a high-potential marker for early detection.

Oncotarget 2017 Sep 4;8(40):68230-68241. Epub 2017 Aug 4.

Department of Biochemistry and Molecular Genetics, Faculty of Medicine, American University of Beirut, Beirut, Lebanon.

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http://dx.doi.org/10.18632/oncotarget.19938DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5620251PMC
September 2017

Alterations in Bronchial Airway miRNA Expression for Lung Cancer Detection.

Cancer Prev Res (Phila) 2017 Nov 6;10(11):651-659. Epub 2017 Sep 6.

The Graduate Program in Bioinformatics, Boston University, Boston, Massachusetts.

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http://dx.doi.org/10.1158/1940-6207.CAPR-17-0098DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6758560PMC
November 2017

The cellular and molecular determinants of emphysematous destruction in COPD.

Sci Rep 2017 08 25;7(1):9562. Epub 2017 Aug 25.

Centre for Heart Lung Innovation, St. Paul's Hospital, Departments of Medicine, and Pathology and Laboratory Medicine, University of British Columbia, Vancouver, BC, Canada.

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http://dx.doi.org/10.1038/s41598-017-10126-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5573394PMC
August 2017

Genomic approaches to accelerate cancer interception.

Lancet Oncol 2017 08 26;18(8):e494-e502. Epub 2017 Jul 26.

Department of Medicine and BU-BMC Cancer Center, Boston University, Boston, MA, USA. Electronic address:

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http://dx.doi.org/10.1016/S1470-2045(17)30373-XDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6020676PMC
August 2017

AJRCCM: 100-Year Anniversary. The Shifting Landscape for Lung Cancer: Past, Present, and Future.

Am J Respir Crit Care Med 2017 05;195(9):1150-1160

3 Section of Computational Biomedicine, Department of Medicine, Boston University Medical Center, Boston, Massachusetts.

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http://dx.doi.org/10.1164/rccm.201702-0433CIDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5439022PMC
May 2017

The airway epithelium undergoes metabolic reprogramming in individuals at high risk for lung cancer.

JCI Insight 2016 11 17;1(19):e88814. Epub 2016 Nov 17.

Division of Allergy, Pulmonary and Critical Care Medicine, Department of Medicine, Cancer Early Detection and Prevention Initiative, Vanderbilt Ingram Cancer Center.

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https://insight.jci.org/articles/view/88814
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http://dx.doi.org/10.1172/jci.insight.88814DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5111517PMC
November 2016

Molecular Impact of Electronic Cigarette Aerosol Exposure in Human Bronchial Epithelium.

Toxicol Sci 2017 01 3;155(1):248-257. Epub 2016 Oct 3.

Section of Computational Biomedicine, Department of Medicine Boston University School of Medicine, Boston, Massachusetts 02118.

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http://dx.doi.org/10.1093/toxsci/kfw198DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5216655PMC
January 2017

Leveraging premalignant biology for immune-based cancer prevention.

Proc Natl Acad Sci U S A 2016 09 16;113(39):10750-8. Epub 2016 Sep 16.

Department of Medicine, Moores Cancer Center, University of California San Diego, La Jolla, CA 92093;

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5047191PMC
http://dx.doi.org/10.1073/pnas.1608077113DOI Listing
September 2016

Update in Lung Cancer 2015.

Am J Respir Crit Care Med 2016 Sep;194(6):661-71

3 Division of Pulmonary, Critical Care and Sleep Medicine, Icahn School of Medicine at Mount Sinai, New York, New York.

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http://www.atsjournals.org/doi/10.1164/rccm.201604-0898UP
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http://dx.doi.org/10.1164/rccm.201604-0898UPDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5027233PMC
September 2016

miR-196b Is Epigenetically Silenced during the Premalignant Stage of Lung Carcinogenesis.

Cancer Res 2016 08 14;76(16):4741-51. Epub 2016 Jun 14.

Lung Cancer Program, Lovelace Respiratory Research Institute, Albuquerque, New Mexico.

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http://dx.doi.org/10.1158/0008-5472.CAN-15-3367DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4987256PMC
August 2016

The Importance of the Biological Impact of Exposure to the Concept of the Exposome.

Environ Health Perspect 2016 10 3;124(10):1504-1510. Epub 2016 Jun 3.

Department of Environmental Health, Rollins School of Public Health, Emory University, Atlanta, Georgia, USA.

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http://dx.doi.org/10.1289/EHP140DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5047763PMC
October 2016

Impact of a bronchial genomic classifier on clinical decision making in patients undergoing diagnostic evaluation for lung cancer.

BMC Pulm Med 2016 May 17;16(1):66. Epub 2016 May 17.

Division of Computational Biomedicine, Department of Medicine, Boston University Medical Center, 715 Albany St, Boston, MA, 02118, USA.

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http://dx.doi.org/10.1186/s12890-016-0217-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4869188PMC
May 2016

Early Events in the Molecular Pathogenesis of Lung Cancer.

Cancer Prev Res (Phila) 2016 Jul 22;9(7):518-27. Epub 2016 Mar 22.

Section of Computational Biomedicine, Boston University School of Medicine, Boston University, Boston, Massachusetts.

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http://dx.doi.org/10.1158/1940-6207.CAPR-15-0400DOI Listing
July 2016

Integrative analyses reveal signaling pathways underlying familial breast cancer susceptibility.

Mol Syst Biol 2016 Mar 10;12(3):860. Epub 2016 Mar 10.

Department of Pharmacology and Toxicology, University of Utah, Salt Lake City, UT, USA Department of Oncological Sciences, University of Utah, Salt Lake City, UT, USA

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4812528PMC
http://dx.doi.org/10.15252/msb.20156506DOI Listing
March 2016

Clinical Utility of a Bronchial Genomic Classifier in Patients With Suspected Lung Cancer.

Chest 2016 Jul 16;150(1):210-8. Epub 2016 Feb 16.

Division of Computational Biomedicine, Department of Medicine, Boston University School of Medicine, Boston, MA.

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http://dx.doi.org/10.1016/j.chest.2016.02.636DOI Listing
July 2016

The Case for a Pre-Cancer Genome Atlas (PCGA).

Cancer Prev Res (Phila) 2016 Feb 1;9(2):119-24. Epub 2016 Feb 1.

Boston University Medical Center, Boston, Massachusetts.

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http://cancerpreventionresearch.aacrjournals.org/cgi/doi/10.
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http://dx.doi.org/10.1158/1940-6207.CAPR-16-0024DOI Listing
February 2016

Gene-expression patterns in peripheral blood classify familial breast cancer susceptibility.

BMC Med Genomics 2015 Nov 4;8:72. Epub 2015 Nov 4.

Department of Pharmacology and Toxicology, University of Utah, Salt Lake City, UT, USA.

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http://dx.doi.org/10.1186/s12920-015-0145-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4634735PMC
November 2015

Update in Lung Cancer 2014.

Am J Respir Crit Care Med 2015 Aug;192(3):283-94

3 Division of Pulmonary, Critical Care, and Sleep Medicine, Icahn School of Medicine at Mount Sinai, New York, New York.

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http://www.atsjournals.org/doi/10.1164/rccm.201504-0756UP
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http://dx.doi.org/10.1164/rccm.201504-0756UPDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4584253PMC
August 2015

A Bronchial Genomic Classifier for the Diagnostic Evaluation of Lung Cancer.

N Engl J Med 2015 Jul 17;373(3):243-51. Epub 2015 May 17.

From the Medical University of South Carolina, Charleston (G.A.S.); the University of Pennsylvania School of Medicine, Philadelphia (A.V., N.M.); Allegro Diagnostics (D.W., K.P.S., E.P.) and the Boston University School of Medicine (J.B., M.E.L., A.S.) - both in Boston; Veracyte, San Francisco (D.W., K.P.S.) and Elashoff Consulting, Redwood City (M.E.) - both in California; and the University of Wisconsin School of Medicine and Public Health, Madison (J.S.F.).

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http://dx.doi.org/10.1056/NEJMoa1504601DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4838273PMC
July 2015

SubmiRine: assessing variants in microRNA targets using clinical genomic data sets.

Nucleic Acids Res 2015 Apr 26;43(8):3886-98. Epub 2015 Mar 26.

Computational and Statistical Genomics Branch, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD 20892, USA

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http://academic.oup.com/nar/article/43/8/3886/2414381/SubmiR
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http://dx.doi.org/10.1093/nar/gkv256DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4417167PMC
April 2015

Translating the transcriptome into tools for the early detection and prevention of lung cancer.

Thorax 2015 May 27;70(5):476-81. Epub 2015 Jan 27.

The Pulmonary Center, Boston University School of Medicine, Boston, Massachusetts, USA Division of Computational Biomedicine, Boston University School of Medicine, Boston, Massachusetts, USA Bioinformatics Program, Boston University, Boston, Massachusetts, USA.

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http://dx.doi.org/10.1136/thoraxjnl-2014-206605DOI Listing
May 2015

Integrative analysis of DNA methylation and gene expression data identifies EPAS1 as a key regulator of COPD.

PLoS Genet 2015 Jan 8;11(1):e1004898. Epub 2015 Jan 8.

Institute of Genomics and Multiscale Biology, Mount Sinai School of Medicine, New York, New York, United States of America; Department of Genetics and Genomic Sciences, Mount Sinai School of Medicine, New York, New York, United States of America.

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http://dx.doi.org/10.1371/journal.pgen.1004898DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4287352PMC
January 2015

Assessment of microRNA differential expression and detection in multiplexed small RNA sequencing data.

RNA 2015 Feb 17;21(2):164-71. Epub 2014 Dec 17.

Bioinformatics Graduate Program, Boston University, Boston, Massachusetts 02215, USA Section of Computational Biomedicine, Boston University Medical Center, Boston, Massachusetts 02118, USA Department of Pathology and Laboratory Medicine, Boston University School of Medicine, Boston, Massachusetts 02118, USA

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http://dx.doi.org/10.1261/rna.046060.114DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4338344PMC
February 2015

Linking polymorphic p53 response elements with gene expression in airway epithelial cells of smokers and cancer risk.

Hum Genet 2014 Dec 2;133(12):1467-76. Epub 2014 Sep 2.

Environmental Genomics Section, Laboratory of Molecular Genetics, National Institute of Environmental Health Sciences, National Institutes of Health, Mail Drop: C3-03, 111 TW Alexander Drive, PO Box 12233, Research Triangle Park, NC, 27709, USA.

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http://dx.doi.org/10.1007/s00439-014-1483-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4225167PMC
December 2014

MODMatcher: multi-omics data matcher for integrative genomic analysis.

PLoS Comput Biol 2014 Aug 14;10(8):e1003790. Epub 2014 Aug 14.

Icahn Institute of Genomics and Multiscale Biology, Icahn School of Medicine at Mount Sinai, New York, New York, United States of America; Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, New York, United States of America.

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http://dx.doi.org/10.1371/journal.pcbi.1003790DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4133046PMC
August 2014

Updates and controversies in the rapidly evolving field of lung cancer screening, early detection, and chemoprevention.

Cancers (Basel) 2014 May 16;6(2):1157-79. Epub 2014 May 16.

Division of Computational Biomedicine, Boston University School of Medicine, 72 East Concord Street, Boston, MA 02118, USA.

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http://dx.doi.org/10.3390/cancers6021157DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4074822PMC
May 2014

Transcriptomic architecture of the adjacent airway field cancerization in non-small cell lung cancer.

J Natl Cancer Inst 2014 Mar 22;106(3):dju004. Epub 2014 Feb 22.

Affiliations of authors: Department of Translational Molecular Pathology (HK, JF, TM, MMG, C-WC, ZC, GM, IIW), Department of Thoracic/Head and Neck Medical Oncology (MK, WKH, IIW), Department of Pathology (NK, CM), Department of Bioinformatics (S-YY, LS, JW, KRC), University of Texas MD Anderson Cancer Center, Houston, TX; Section of Computational Medicine, Department of Medicine, Boston University, Boston, MA (ACG, AS).

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http://dx.doi.org/10.1093/jnci/dju004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3982778PMC
March 2014

PGE2-driven expression of c-Myc and oncomiR-17-92 contributes to apoptosis resistance in NSCLC.

Mol Cancer Res 2014 May 27;12(5):765-74. Epub 2014 Jan 27.

Authors' Affiliations: Departments of Medicine, 2Pathology and Laboratory Medicine, 3Molecular and Medical Pharmacology, 4Anesthesiology, and 5Medicine Statistics Core, David Geffen School of Medicine, University of California, Los Angeles; 6UCLA Jonsson Comprehensive Cancer Center; 7West Los Angeles VA Healthcare System, Los Angeles; 8City of Hope Comprehensive Cancer Center, Duarte, California; and 9Boston University, Boston, Massachusetts.

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http://dx.doi.org/10.1158/1541-7786.MCR-13-0377DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4020971PMC
May 2014

miR-638 regulates gene expression networks associated with emphysematous lung destruction.

Genome Med 2013 31;5(12):114. Epub 2013 Dec 31.

Division of Computational Biomedicine, Department of Medicine, Boston University School of Medicine, 72 East Concord Street Boston, MA 02118, USA ; Bioinformatics Program, Boston University, 44 Cummington Street Boston, MA 02215, USA.

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http://dx.doi.org/10.1186/gm519DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3971345PMC
May 2014

Personalized management of chronic obstructive pulmonary disease via transcriptomic profiling of the airway and lung.

Ann Am Thorac Soc 2013 Dec;10 Suppl:S190-6

1 Division of Computational Biomedicine, Department of Medicine, and.

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http://dx.doi.org/10.1513/AnnalsATS.201306-190AWDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3960986PMC
December 2013

Challenge and opportunity of targeted lung cancer chemoprevention.

J Clin Oncol 2013 Nov 3;31(33):4169-71. Epub 2013 Sep 3.

David Geffen School of Medicine at University of California, Los Angeles, Los Angeles, CA.

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http://dx.doi.org/10.1200/JCO.2013.51.2400DOI Listing
November 2013

Promoting interdisciplinary research in departments of medicine: results from two models at Boston University School of Medicine.

Trans Am Clin Climatol Assoc 2013 ;124:275-82

Department of Medicine, Boston University School of Medicine, Boston, MA 02118, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3715902PMC
March 2014

Influence of vitamin D status and vitamin D3 supplementation on genome wide expression of white blood cells: a randomized double-blind clinical trial.

PLoS One 2013 20;8(3):e58725. Epub 2013 Mar 20.

Department of Medicine, Section of Endocrinology, Nutrition, and Diabetes, Vitamin D, Skin and Bone Research Laboratory, Boston University Medical Center, Boston, Massachusetts, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0058725PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3604145PMC
September 2013

Comparison of nasal epithelial smoking-induced gene expression on Affymetrix Exon 1.0 and Gene 1.0 ST arrays.

ScientificWorldJournal 2013 17;2013:951416. Epub 2013 Feb 17.

Division of Computational Biomedicine, Boston University School of Medicine, 72 East Concord Street, E631, Boston, MA 02118, USA.

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http://dx.doi.org/10.1155/2013/951416DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3588192PMC
September 2013

Enriching the molecular definition of the airway "field of cancerization:" establishing new paradigms for the patient at risk for lung cancer.

Cancer Prev Res (Phila) 2013 Jan 11;6(1):4-7. Epub 2012 Dec 11.

1Division of Hematology Oncology, Department of Pediatrics, Mattel Children's Hospital at the University of California, Los Angeles (UCLA), Los Angeles, CA, USA.

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http://dx.doi.org/10.1158/1940-6207.CAPR-12-0470DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3717378PMC
January 2013

Using microRNAs to inform clinical decision making in lung cancer: ready for prime time?

Am J Respir Crit Care Med 2012 Dec;186(11):1077-9

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http://dx.doi.org/10.1164/rccm.201210-1757EDDOI Listing
December 2012

SIRT1 pathway dysregulation in the smoke-exposed airway epithelium and lung tumor tissue.

Cancer Res 2012 Nov 17;72(22):5702-11. Epub 2012 Sep 17.

Section of Computational Biomedicine, Department of Medicine, Boston University Medical Center; Bioinformatics Program, Boston University, Boston, Massachusetts, USA.

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http://dx.doi.org/10.1158/0008-5472.CAN-12-1043DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4053174PMC
November 2012

A gene expression signature of emphysema-related lung destruction and its reversal by the tripeptide GHK.

Genome Med 2012 31;4(8):67. Epub 2012 Aug 31.

Division of Computational Biomedicine, Department of Medicine, Boston University School of Medicine, 72 East Concord Street, Boston, MA 02118, USA ; Bioinformatics Program, Boston University, 44 Cummington Street, Boston, MA 02215, USA.

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http://dx.doi.org/10.1186/gm367DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4064320PMC
August 2014