Avner Schlessinger

Avner Schlessinger

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Avner Schlessinger

Publications by authors named "Avner Schlessinger"

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Advances and Challenges in Rational Drug Design for SLCs.

Trends Pharmacol Sci 2019 Sep 10. Epub 2019 Sep 10.

Department of Pharmacological Sciences, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA. Electronic address:

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http://dx.doi.org/10.1016/j.tips.2019.08.006DOI Listing
September 2019

l-Type amino acid transporter 1 activity of 1,2,3-triazolyl analogs of l-histidine and l-tryptophan.

Bioorg Med Chem Lett 2019 Aug 20;29(16):2254-2258. Epub 2019 Jun 20.

Department of Chemistry, University of Nebraska at Kearney, Kearney, NE 69949, USA. Electronic address:

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http://dx.doi.org/10.1016/j.bmcl.2019.06.033DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6690782PMC
August 2019

Functional and structural analysis of rare SLC2A2 variants associated with Fanconi-Bickel syndrome and metabolic traits.

Hum Mutat 2019 Jul 25;40(7):983-995. Epub 2019 Apr 25.

Department of Bioengineering and Therapeutic Sciences, University of California, San Francisco, San Francisco, California.

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http://dx.doi.org/10.1002/humu.23758DOI Listing
July 2019

Integrated computational and Drosophila cancer model platform captures previously unappreciated chemicals perturbing a kinase network.

PLoS Comput Biol 2019 Apr 26;15(4):e1006878. Epub 2019 Apr 26.

Department of Pharmacological Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, United States of America.

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http://dx.doi.org/10.1371/journal.pcbi.1006878DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6506148PMC
April 2019

KinaMetrix: a web resource to investigate kinase conformations and inhibitor space.

Nucleic Acids Res 2019 Jan;47(D1):D361-D366

Department of Pharmacological Sciences, Icahn school of Medicine at Mount Sinai, New York, NY 10029, USA.

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http://dx.doi.org/10.1093/nar/gky916DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6323924PMC
January 2019

Encounter and React: Computer-Guided Design of Covalent Inhibitors.

Cell Chem Biol 2019 01;26(1):6-8

Department of Pharmacological Sciences, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA. Electronic address:

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http://dx.doi.org/10.1016/j.chembiol.2018.12.009DOI Listing
January 2019

Molecular Modeling of Drug-Transporter Interactions-An International Transporter Consortium Perspective.

Clin Pharmacol Ther 2018 11 30;104(5):818-835. Epub 2018 Aug 30.

Department of Pharmacy, Uppsala University, Uppsala, Sweden.

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http://dx.doi.org/10.1002/cpt.1174DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6197929PMC
November 2018

Novel selective thiadiazine DYRK1A inhibitor lead scaffold with human pancreatic β-cell proliferation activity.

Eur J Med Chem 2018 Sep 22;157:1005-1016. Epub 2018 Aug 22.

Drug Discovery Institute, Icahn School of Medicine at Mount Sinai, New York, NY, 10029, USA; Department of Pharmacological Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, 10029, USA. Electronic address:

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http://dx.doi.org/10.1016/j.ejmech.2018.08.007DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6396881PMC
September 2018

Redefining the Protein Kinase Conformational Space with Machine Learning.

Cell Chem Biol 2018 07 31;25(7):916-924.e2. Epub 2018 May 31.

Department of Pharmacological Sciences, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S24519456183014
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http://dx.doi.org/10.1016/j.chembiol.2018.05.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6054563PMC
July 2018

Homology Modeling Informs Ligand Discovery for the Glutamine Transporter ASCT2.

Front Chem 2018 24;6:279. Epub 2018 Jul 24.

Department of Pharmacological Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, United States.

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http://dx.doi.org/10.3389/fchem.2018.00279DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6066518PMC
July 2018

A whole-animal platform to advance a clinical kinase inhibitor into new disease space.

Nat Chem Biol 2018 03 22;14(3):291-298. Epub 2018 Jan 22.

Department of Oncological Sciences, Icahn School of Medicine at Mount Sinai, New York, New York, USA.

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http://dx.doi.org/10.1038/nchembio.2556DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5931369PMC
March 2018

Effects of Mutations and Ligands on the Thermostability of the l-Arginine/Agmatine Antiporter AdiC and Deduced Insights into Ligand-Binding of Human l-Type Amino Acid Transporters.

Int J Mol Sci 2018 Mar 20;19(3). Epub 2018 Mar 20.

Institute of Biochemistry and Molecular Medicine, and Swiss National Centre of Competence in Research (NCCR) TransCure, University of Bern, CH-3012 Bern, Switzerland.

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http://dx.doi.org/10.3390/ijms19030918DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5877779PMC
March 2018

Generation of G protein-coupled receptor antibodies differentially sensitive to conformational states.

PLoS One 2017 1;12(11):e0187306. Epub 2017 Nov 1.

Department of Pharmacological Sciences, Icahn School of Medicine at Mount Sinai, New York, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0187306PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5665533PMC
December 2017

Chemical Modulation of the Human Oligopeptide Transporter 1, hPepT1.

Mol Pharm 2017 12 15;14(12):4685-4693. Epub 2017 Nov 15.

Department of Pharmacological Sciences, Icahn School of Medicine at Mount Sinai , New York, New York 10029, United States.

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http://dx.doi.org/10.1021/acs.molpharmaceut.7b00775DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5826771PMC
December 2017

Multi-targeting Drug Community Challenge.

Cell Chem Biol 2017 12;24(12):1434-1435

Department of Cell, Developmental and Regenerative Biology and School of Biomedical Sciences, Icahn School of Medicine at Mount Sinai, One Gustave Levy Place, New York, NY 10029, USA. Electronic address:

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http://dx.doi.org/10.1016/j.chembiol.2017.12.006DOI Listing
December 2017

Mapping Functionally Important Residues in the Na/Dicarboxylate Cotransporter, NaDC1.

Biochemistry 2017 08 10;56(33):4432-4441. Epub 2017 Aug 10.

Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California-San Diego , La Jolla, California 92130-0714, United States.

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http://dx.doi.org/10.1021/acs.biochem.7b00503DOI Listing
August 2017

Human Concentrative Nucleoside Transporter 3 (hCNT3, SLC28A3) Forms a Cyclic Homotrimer.

Biochemistry 2017 07 29;56(27):3475-3483. Epub 2017 Jun 29.

Department of Bioengineering and Therapeutic Sciences, University of California, San Francisco , San Francisco, California 94158, United States.

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http://dx.doi.org/10.1021/acs.biochem.7b00339DOI Listing
July 2017

Structure activity relationships of benzylproline-derived inhibitors of the glutamine transporter ASCT2.

Bioorg Med Chem Lett 2017 02 27;27(3):398-402. Epub 2016 Dec 27.

Department of Chemistry, Binghamton University, 4400 Vestal Pkwy East, Binghamton, NY 13902, United States. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S0960894X163134
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http://dx.doi.org/10.1016/j.bmcl.2016.12.063DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5363072PMC
February 2017

GEN3VA: aggregation and analysis of gene expression signatures from related studies.

BMC Bioinformatics 2016 Nov 15;17(1):461. Epub 2016 Nov 15.

Department of Pharmacological Sciences, One Gustave L. Levy Place, Box 1603, New York, NY, 10029, USA.

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http://dx.doi.org/10.1186/s12859-016-1321-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5111283PMC
November 2016

Inhibitor Discovery for the Human GLUT1 from Homology Modeling and Virtual Screening.

ACS Chem Biol 2016 07 11;11(7):1908-16. Epub 2016 May 11.

Department of Pharmacology and Systems Therapeutics, Icahn School of Medicine at Mount Sinai , New York, New York 10029, United States.

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http://dx.doi.org/10.1021/acschembio.6b00304DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5356226PMC
July 2016

Molecular Basis for Redox Activation of Epidermal Growth Factor Receptor Kinase.

Cell Chem Biol 2016 07 14;23(7):837-848. Epub 2016 Jul 14.

Department of Chemistry, The Scripps Research Institute, Jupiter, FL 33458, USA. Electronic address:

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http://dx.doi.org/10.1016/j.chembiol.2016.05.017DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4958504PMC
July 2016

LAT-1 activity of meta-substituted phenylalanine and tyrosine analogs.

Bioorg Med Chem Lett 2016 06 11;26(11):2616-2621. Epub 2016 Apr 11.

Department of Chemistry, University of Nebraska Kearney, Kearney, NE, 68849.

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http://dx.doi.org/10.1016/j.bmcl.2016.04.023DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4875506PMC
June 2016

SLC Transporters: Structure, Function, and Drug Discovery.

Medchemcomm 2016 Jun 28;7(6):1069-1081. Epub 2016 Mar 28.

Department of Pharmacology and Systems Therapeutics, Icahn School of Medicine at Mount Sinai, New York, NY 10029.; Department of Structural and Chemical Biology, Icahn School of Medicine at Mount Sinai, New York, NY 10029.

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http://xlink.rsc.org/?DOI=C6MD00005C
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http://dx.doi.org/10.1039/C6MD00005CDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5034948PMC
June 2016

Environmental Pressure May Change the Composition Protein Disorder in Prokaryotes.

PLoS One 2015 7;10(8):e0133990. Epub 2015 Aug 7.

TUM, Department of Informatics, Bioinformatics & Computational Biology-i12, Boltzmannstr. 3, 85748 Garching, Munich, Germany; Institute of Advanced Study (TUM-IAS), Lichtenbergstr. 2a, 85748 Garching, Munich, Germany; Institute for Food and Plant Sciences WZW Weihenstephan, Alte Akademie 8, Freising, Germany.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0133990PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4529154PMC
May 2016

Mutations in the Na(+)/citrate cotransporter NaCT (SLC13A5) in pediatric patients with epilepsy and developmental delay.

Mol Med 2016 05 26;22. Epub 2016 May 26.

Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California-San Diego, La Jolla, CA 92130-0718.

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http://dx.doi.org/10.2119/molmed.2016.00077DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5023510PMC
May 2016

Interaction of Bacillus subtilis Polynucleotide Phosphorylase and RNase Y: STRUCTURAL MAPPING AND EFFECT ON mRNA TURNOVER.

J Biol Chem 2016 Mar 21;291(13):6655-63. Epub 2016 Jan 21.

From the Department of Pharmacology and Systems Therapeutics, Icahn School of Medicine at Mount Sinai, New York, New York 10029

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http://www.jbc.org/lookup/doi/10.1074/jbc.M115.711044
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http://dx.doi.org/10.1074/jbc.M115.711044DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4807252PMC
March 2016

Computing Substrate Selectivity in a Peptide Transporter.

Cell Chem Biol 2016 Feb;23(2):211-213

Departments of Pharmacology and Systems Therapeutics, and Structural and Chemical Biology, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA. Electronic address:

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http://dx.doi.org/10.1016/j.chembiol.2016.02.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5457801PMC
February 2016

Ligand Discovery for the Alanine-Serine-Cysteine Transporter (ASCT2, SLC1A5) from Homology Modeling and Virtual Screening.

PLoS Comput Biol 2015 Oct 7;11(10):e1004477. Epub 2015 Oct 7.

Department of Pharmacology and Systems Therapeutics, Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, New York, United States of America.

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http://dx.plos.org/10.1371/journal.pcbi.1004477
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http://dx.doi.org/10.1371/journal.pcbi.1004477DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4596572PMC
October 2015

Structure-Based Identification of Inhibitors for the SLC13 Family of Na(+)/Dicarboxylate Cotransporters.

Biochemistry 2015 Aug 30;54(31):4900-8. Epub 2015 Jul 30.

†Department of Pharmacology and Systems Therapeutics, Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, New York 10029, United States.

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http://pubs.acs.org/doi/10.1021/acs.biochem.5b00388
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http://dx.doi.org/10.1021/acs.biochem.5b00388DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4781755PMC
August 2015

DFGmodel: predicting protein kinase structures in inactive states for structure-based discovery of type-II inhibitors.

ACS Chem Biol 2015 Jan 9;10(1):269-78. Epub 2014 Dec 9.

Department of Pharmacology and Systems Therapeutics, Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai , New York, New York 10029, United States.

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http://dx.doi.org/10.1021/cb500696tDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4301084PMC
January 2015

PredictProtein--an open resource for online prediction of protein structural and functional features.

Nucleic Acids Res 2014 Jul 5;42(Web Server issue):W337-43. Epub 2014 May 5.

Department of Informatics, Bioinformatics & Computational Biology i12, TUM (Technische Universität München), Garching/Munich 85748, Germany Biosof LLC, New York, NY 10001, USA New York Consortium on Membrane Protein Structure (NYCOMPS), Columbia University, New York, NY 10032, USA The Department of Biochemistry and Molecular Biology, George S. Wise Faculty of Life Sciences, Tel Aviv University, 69978 Tel Aviv, Israel Department of Biochemistry and Molecular Biophysics & New York Consortium on Membrane Protein Structure (NYCOMPS), Columbia University, New York, NY 10032, USA Institute for Advanced Study (TUM-IAS), Garching/Munich 85748, Germany.

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http://dx.doi.org/10.1093/nar/gku366DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4086098PMC
July 2014

Determinants of substrate and cation transport in the human Na+/dicarboxylate cotransporter NaDC3.

J Biol Chem 2014 Jun 7;289(24):16998-7008. Epub 2014 May 7.

the Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California, San Diego, La Jolla, California 92130-0718

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http://dx.doi.org/10.1074/jbc.M114.554790DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4059142PMC
June 2014

Molecular modeling and ligand docking for solute carrier (SLC) transporters.

Curr Top Med Chem 2013 ;13(7):843-56

Department of Bioengineering and Therapeutic Sciences, University of California, San Francisco, 1700 4th Street, San Francisco, CA 94158, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4056341PMC
http://dx.doi.org/10.2174/1568026611313070007DOI Listing
April 2014

Co-expression and co-localization of hub proteins and their partners are encoded in protein sequence.

Mol Biosyst 2014 Apr 23;10(4):787-94. Epub 2014 Jan 23.

The Goodman faculty of life sciences, Bar Ilan University, Ramat Gan 52900, Israel.

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http://xlink.rsc.org/?DOI=c3mb70411d
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http://dx.doi.org/10.1039/c3mb70411dDOI Listing
April 2014

Structural basis for alternating access of a eukaryotic calcium/proton exchanger.

Nature 2013 Jul 19;499(7456):107-10. Epub 2013 May 19.

Department of Biochemistry and Biophysics, University of California, San Francisco, California 94158, USA.

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http://dx.doi.org/10.1038/nature12233DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3702627PMC
July 2013

Structure-based ligand discovery for the Large-neutral Amino Acid Transporter 1, LAT-1.

Proc Natl Acad Sci U S A 2013 Apr 18;110(14):5480-5. Epub 2013 Mar 18.

Department of Bioengineering and Therapeutic Sciences, University of California, San Francisco, CA 94158, USA.

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http://dx.doi.org/10.1073/pnas.1218165110DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3619328PMC
April 2013

High selectivity of the γ-aminobutyric acid transporter 2 (GAT-2, SLC6A13) revealed by structure-based approach.

J Biol Chem 2012 Nov 29;287(45):37745-56. Epub 2012 Aug 29.

Department of Bioengineering and Therapeutic Sciences, University of California, San Francisco, California 94158, USA.

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http://dx.doi.org/10.1074/jbc.M112.388157DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3488050PMC
November 2012

Structure-based discovery of prescription drugs that interact with the norepinephrine transporter, NET.

Proc Natl Acad Sci U S A 2011 Sep 1;108(38):15810-5. Epub 2011 Sep 1.

Department of Bioengineering and Therapeutic Sciences, and California Institute for Quantitative Biosciences, University of California, San Francisco, CA 94158, USA.

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http://www.pnas.org/cgi/doi/10.1073/pnas.1106030108
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http://dx.doi.org/10.1073/pnas.1106030108DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3179104PMC
September 2011

Ligand discovery from a dopamine D3 receptor homology model and crystal structure.

Nat Chem Biol 2011 Sep 18;7(11):769-78. Epub 2011 Sep 18.

Department of Pharmaceutical Chemistry, University of California San Francisco, San Francisco, California, USA.

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http://dx.doi.org/10.1038/nchembio.662DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3197762PMC
September 2011

Protein disorder--a breakthrough invention of evolution?

Curr Opin Struct Biol 2011 Jun 20;21(3):412-8. Epub 2011 Apr 20.

Department of Bioengineering and Therapeutic Sciences, and California Institute for Quantitative Biosciences, University of California-San Francisco, CA, USA.

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http://dx.doi.org/10.1016/j.sbi.2011.03.014DOI Listing
June 2011

ModBase, a database of annotated comparative protein structure models, and associated resources.

Nucleic Acids Res 2011 Jan 19;39(Database issue):D465-74. Epub 2010 Nov 19.

Department of Bioengineering and Therapeutic Sciences, Department of Pharmaceutical Chemistry, and California Institute for Quantitative Biosciences, University of California at San Francisco, CA 94158, USA.

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http://dx.doi.org/10.1093/nar/gkq1091DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3013688PMC
January 2011

Role of organic cation transporter 3 (SLC22A3) and its missense variants in the pharmacologic action of metformin.

Pharmacogenet Genomics 2010 Nov;20(11):687-99

Department of Bioengineering and Therapeutic Sciences, University of California at San Francisco, San Francisco, California 94158, USA.

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http://dx.doi.org/10.1097/FPC.0b013e32833fe789DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2976715PMC
November 2010

Integrative structure modeling of macromolecular assemblies from proteomics data.

Mol Cell Proteomics 2010 Aug 27;9(8):1689-702. Epub 2010 May 27.

Department of Bioengineering and Therapeutic Sciences, University of California, San Francisco, California 94158, USA.

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http://dx.doi.org/10.1074/mcp.R110.000067DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2938050PMC
August 2010

Function of human Rh based on structure of RhCG at 2.1 A.

Proc Natl Acad Sci U S A 2010 May 10;107(21):9638-43. Epub 2010 May 10.

Department of Biochemistry and Biophysics, S412C Genentech Hall, Center for the Structure of Membrane Proteins, and Membrane Protein Expression Center, University of California, San Francisco, CA 94158, USA.

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http://dx.doi.org/10.1073/pnas.1003587107DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2906887PMC
May 2010

Comparison of human solute carriers.

Protein Sci 2010 Mar;19(3):412-28

Department of Bioengineering and Therapeutic Sciences, California Institute for Quantitative Biosciences, University of California, San Francisco, California.

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http://salilab.org/pdf/Schlessinger_ProteinSci_2010.pdf
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http://mpec.ucsf.edu/pdfs_new/Pubs_50.pdf
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http://doi.wiley.com/10.1002/pro.320
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http://dx.doi.org/10.1002/pro.320DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2866268PMC
March 2010

Protein secondary structure appears to be robust under in silico evolution while protein disorder appears not to be.

Bioinformatics 2010 Mar 16;26(5):625-31. Epub 2010 Jan 16.

Department of Biochemistry and Molecular Biophysics, Center for Computational Biology and Bioinformatics (C2B2), Columbia University, 1130 St Nicholas Ave., New York, NY 10032, USA.

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http://dx.doi.org/10.1093/bioinformatics/btq012DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2828120PMC
March 2010

Improved disorder prediction by combination of orthogonal approaches.

PLoS One 2009 11;4(2):e4433. Epub 2009 Feb 11.

CUBIC, Department of Biochemistry and Molecular Biophysics, Columbia University, New York, New York, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0004433PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2635965PMC
April 2009

Automated identification of complementarity determining regions (CDRs) reveals peculiar characteristics of CDRs and B cell epitopes.

J Immunol 2008 Nov;181(9):6230-5

The Mina and Everard Goodman Faculty of Life Science, Bar Ilan University, Ramat-Gan Israel.

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http://dx.doi.org/10.4049/jimmunol.181.9.6230DOI Listing
November 2008

Natively unstructured regions in proteins identified from contact predictions.

Bioinformatics 2007 Sep 20;23(18):2376-84. Epub 2007 Aug 20.

Department of Biochemistry and Molecular Biophysics, Columbia University, New York, NY, USA.

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http://dx.doi.org/10.1093/bioinformatics/btm349DOI Listing
September 2007

Natively unstructured loops differ from other loops.

PLoS Comput Biol 2007 Jul;3(7):e140

Department of Biochemistry and Molecular Biophysics, Columbia University, New York, New York, USA.

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http://dx.doi.org/10.1371/journal.pcbi.0030140DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1924875PMC
July 2007

PROFbval: predict flexible and rigid residues in proteins.

Bioinformatics 2006 Apr 2;22(7):891-3. Epub 2006 Feb 2.

CUBIC, Department of Biochemistry and Molecular Biophysics, Columbia University, 650 West 168th Street BB217, New York, NY 10032, USA.

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http://dx.doi.org/10.1093/bioinformatics/btl032DOI Listing
April 2006

Epitome: database of structure-inferred antigenic epitopes.

Nucleic Acids Res 2006 Jan;34(Database issue):D777-80

CUBIC, Department of Biochemistry and Molecular Biophysics, Columbia University, 1130 St Nicholas Avenue, room 804, New York, NY 10032, USA.

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http://dx.doi.org/10.1093/nar/gkj053DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1347416PMC
January 2006

Protein flexibility and rigidity predicted from sequence.

Proteins 2005 Oct;61(1):115-26

CUBIC, Department of Biochemistry and Molecular Biophysics, Columbia University, New York, New York 10032, USA.

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http://dx.doi.org/10.1002/prot.20587DOI Listing
October 2005

Using multiple structure alignments, fast model building, and energetic analysis in fold recognition and homology modeling.

Proteins 2003 ;53 Suppl 6:430-5

Howard Hughes Medical Institute, Department of Biochemistry and Molecular Biophysics, Center for Computational Biology and Bioinformatics, Columbia University New York, New York 10032, USA.

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http://dx.doi.org/10.1002/prot.10550DOI Listing
January 2004