Avan A Sayer

Avan A Sayer

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Avan A Sayer

Publications by authors named "Avan A Sayer"

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Multimorbidity Predicts Quality of Life but not Motor Severity in Early Parkinson's Disease.

J Parkinsons Dis 2018 ;8(4):511-515

Institute of Neuroscience, Newcastle University, Newcastle upon Tyne, UK.

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http://dx.doi.org/10.3233/JPD-181428DOI Listing
October 2019

Quadriceps miR-542-3p and -5p are elevated in COPD and reduce function by inhibiting ribosomal and protein synthesis.

J Appl Physiol (1985) 2019 Jun 24;126(6):1514-1524. Epub 2019 Jan 24.

Molecular Medicine Section, National Heart and Lung Institute, Imperial College, South Kensington Campus, London , United Kingdom.

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http://dx.doi.org/10.1152/japplphysiol.00882.2018DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6551227PMC
June 2019

Sarcopenia.

Lancet 2019 Jun 3;393(10191):2636-2646. Epub 2019 Jun 3.

AGE Research Group, Institute of Neuroscience, Newcastle University, Newcastle upon Tyne, UK; National Institute for Health Research, Newcastle Biomedical Research Centre, Newcastle upon Tyne Hospitals NHS Foundation Trust, Newcastle upon Tyne, UK; Newcastle University, Newcastle upon Tyne, UK.

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https://linkinghub.elsevier.com/retrieve/pii/S01406736193113
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http://dx.doi.org/10.1016/S0140-6736(19)31138-9DOI Listing
June 2019

Comprehensive geriatric assessment in primary care: a systematic review.

Aging Clin Exp Res 2019 Apr 9. Epub 2019 Apr 9.

Academic Geriatric Medicine, Faculty of Medicine, University of Southampton, Southampton, UK.

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http://dx.doi.org/10.1007/s40520-019-01183-wDOI Listing
April 2019

Dietary Patterns, Skeletal Muscle Health, and Sarcopenia in Older Adults.

Nutrients 2019 Mar 30;11(4). Epub 2019 Mar 30.

AGE Research Group, Institute of Neuroscience, The Medical School, Newcastle University, Newcastle upon Tyne NE2 4HH, UK.

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http://dx.doi.org/10.3390/nu11040745DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6521630PMC
March 2019

The feasibility of assessing frailty and sarcopenia in hospitalised older people: a comparison of commonly used tools.

BMC Geriatr 2019 02 15;19(1):42. Epub 2019 Feb 15.

Academic Geriatric Medicine, University of Southampton, Southampton, UK.

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http://dx.doi.org/10.1186/s12877-019-1053-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6377779PMC
February 2019

Assessment and Treatment of the Anorexia of Aging: A Systematic Review.

Nutrients 2019 Jan 11;11(1). Epub 2019 Jan 11.

Academic Geriatric Medicine, Faculty of Medicine, University of Southampton, Southampton SO16 6YD, UK.

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http://dx.doi.org/10.3390/nu11010144DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6356473PMC
January 2019

Effects of dietary patterns and low protein intake on sarcopenia risk in the very old: The Newcastle 85+ study.

Clin Nutr 2019 Jan 21. Epub 2019 Jan 21.

Newcastle University Institute for Ageing, Newcastle Upon Tyne, United Kingdom; Institute of Health & Society, Newcastle University, Newcastle Upon Tyne, United Kingdom.

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http://dx.doi.org/10.1016/j.clnu.2019.01.009DOI Listing
January 2019

miR-424-5p reduces ribosomal RNA and protein synthesis in muscle wasting.

J Cachexia Sarcopenia Muscle 2018 04 7;9(2):400-416. Epub 2017 Dec 7.

Molecular Medicine Section, National Heart and Lung Institute, Imperial College London, South Kensington Campus, London, SW7 2AZ, UK.

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http://dx.doi.org/10.1002/jcsm.12266DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5879973PMC
April 2018

Influence of Poor Oral Health on Physical Frailty: A Population-Based Cohort Study of Older British Men.

J Am Geriatr Soc 2018 03 20;66(3):473-479. Epub 2017 Dec 20.

Department of Primary Care and Population Health, Institute of Epidemiology and Health Care, University College of London, London, United Kingdom.

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http://dx.doi.org/10.1111/jgs.15175DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5887899PMC
March 2018

Implementation of grip strength measurement in medicine for older people wards as part of routine admission assessment: identifying facilitators and barriers using a theory-led intervention.

BMC Geriatr 2018 03 22;18(1):79. Epub 2018 Mar 22.

Academic Geriatric Medicine, University of Southampton, Southampton General Hospital, Mailpoint 807, Tremona Road, Southampton, SO16 6YD, UK.

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http://dx.doi.org/10.1186/s12877-018-0768-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5865333PMC
March 2018

Nutrition in the Very Old.

Nutrients 2018 Feb 27;10(3). Epub 2018 Feb 27.

Institute of Neuroscience, The Medical School, Newcastle University, Newcastle upon Tyne NE2 4HH, UK.

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http://dx.doi.org/10.3390/nu10030269DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5872687PMC
February 2018

Physical capability predicts mortality in late mid-life as well as in old age: Findings from a large British cohort study.

Arch Gerontol Geriatr 2018 Jan 4;74:77-82. Epub 2017 Oct 4.

Department of Public Health and Primary Care, University of Cambridge, Strangeways Research Laboratory, Wort's Causeway, Cambridge, CB1 8RN, UK.

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http://dx.doi.org/10.1016/j.archger.2017.10.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5701965PMC
January 2018

Learning from older peoples' reasons for participating in demanding, intensive epidemiological studies: a qualitative study.

BMC Med Res Methodol 2017 Dec 12;17(1):167. Epub 2017 Dec 12.

Academic Geriatric Medicine, University of Southampton, Southampton, UK.

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http://dx.doi.org/10.1186/s12874-017-0439-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5727983PMC
December 2017

Initial level and rate of change in grip strength predict all-cause mortality in very old adults.

Age Ageing 2017 11;46(6):970-976

AGE Research Group, Institute of Neuroscience, Newcastle University, Newcastle upon Tyne, UK.

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http://dx.doi.org/10.1093/ageing/afx087DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5860048PMC
November 2017

Use of the electronic Frailty Index to identify vulnerable patients: a pilot study in primary care.

Br J Gen Pract 2017 Nov 25;67(664):e751-e756. Epub 2017 Sep 25.

National Institute for Health Research (NIHR) Newcastle Biomedical Research Centre, and professor of geriatric medicine, Academic Geriatric Medicine, NIHR Collaboration for Leadership in Applied Health Research and Care (NIHR CLAHRC) Wessex, University of Southampton, Southampton, Ageing, Geriatrics and Epidemiology, Institute of Neuroscience, Newcastle University, Newcastle upon Tyne, and National Institute for Health Research (NIHR) Newcastle Biomedical Research Centre in Ageing and Chronic Disease, Newcastle upon Tyne NHS Foundation Trust and Newcastle University, Newcastle upon Tyne.

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http://dx.doi.org/10.3399/bjgp17X693089DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5647918PMC
November 2017

New horizons in multimorbidity in older adults.

Age Ageing 2017 11;46(6):882-888

School of Psychology, Bangor University, Bangor, UK.

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http://dx.doi.org/10.1093/ageing/afx150DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5860018PMC
November 2017

Methodological challenges in a study on falls in an older population of Cape Town, South Africa.

Afr Health Sci 2017 Sep;17(3):912-922

MRC Lifecourse Epidemiology Unit, Faculty of Medicine, University of Southampton, United Kingdom.

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http://dx.doi.org/10.4314/ahs.v17i3.35DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5656198PMC
September 2017

Can routine clinical data identify older patients at risk of poor healthcare outcomes on admission to hospital?

BMC Res Notes 2017 Aug 10;10(1):384. Epub 2017 Aug 10.

Academic Geriatric Medicine, University of Southampton, Southampton General Hospital, Tremona Road, Mailpoint 807, Southampton, SO16 6YD, UK.

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http://dx.doi.org/10.1186/s13104-017-2705-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5553791PMC
August 2017

Epidemiology of sarcopenia and insight into possible therapeutic targets.

Nat Rev Rheumatol 2017 Jun 4;13(6):340-347. Epub 2017 May 4.

MRC Lifecourse Epidemiology Unit, University of Southampton, Southampton General Hospital, Tremona Road, Southampton SO16 6YD, UK.

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http://dx.doi.org/10.1038/nrrheum.2017.60DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5444517PMC
June 2017

Selecting Potential Pharmacological Interventions in Sarcopenia.

Drugs Aging 2017 04;34(4):233-240

Ageing and Health, University of Dundee, Dundee, UK.

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http://dx.doi.org/10.1007/s40266-017-0444-zDOI Listing
April 2017

Vitamin D Status, Muscle Strength and Physical Performance Decline in Very Old Adults: A Prospective Study.

Nutrients 2017 Apr 13;9(4). Epub 2017 Apr 13.

Institute of Neuroscience, The Medical School, Newcastle University, Newcastle upon Tyne NE2 4HH, UK.

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http://dx.doi.org/10.3390/nu9040379DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5409718PMC
April 2017

The use of volunteers to help older medical patients mobilise in hospital: a systematic review.

J Clin Nurs 2016 Nov 1;25(21-22):3102-3112. Epub 2016 Aug 1.

Academic Geriatric Medicine, University of Southampton, Southampton, UK.

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http://dx.doi.org/10.1111/jocn.13317DOI Listing
November 2016

Increased expression of H19/miR-675 is associated with a low fat-free mass index in patients with COPD.

J Cachexia Sarcopenia Muscle 2016 06 5;7(3):330-44. Epub 2016 Jan 5.

Molecular Medicine Section National Heart and Lung Institute, Imperial College South Kensington Campus London SW7 2AZ UK.

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http://dx.doi.org/10.1002/jcsm.12078DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4863928PMC
June 2016

A feasibility study of implementing grip strength measurement into routine hospital practice (GRImP): study protocol.

Pilot Feasibility Stud 2016 6;2:27. Epub 2016 Jun 6.

Academic Geriatric Medicine, Mailpoint 807, Southampton General Hospital, Tremona Road, Southampton, SO16 6YD UK ; NIHR CLAHRC: Wessex, Faculty of Health Sciences, University of Southampton, Highfield, Southampton, SO17 1BJ UK ; Medicine for Older People, Mailpoint 63, Southampton General Hospital, Tremona Road, Southampton, SO16 6YD UK.

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http://dx.doi.org/10.1186/s40814-016-0067-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5154137PMC
June 2016

Current Clinical Care of Older Adults With Sarcopenia.

J Clin Densitom 2015 Oct-Dec;18(4):493-8. Epub 2015 Jun 16.

Academic Geriatric Medicine and MRC Lifecourse Epidemiology Unit, University of Southampton, Southampton General Hospital, Southampton SO16 6YD, UK; MRC Lifecourse Epidemiology Unit; NIHR Southampton Biomedical Research Centre, University of Southampton and University Hospital Southampton NHS Foundation Trust, Southampton SO16 6YD, UK; University Hospital Southampton NHS Foundation Trust, NIHR CLAHRC:Wessex, Faculty of Health Sciences, University of Southampton, Southampton SO17 1FH, UK.

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http://dx.doi.org/10.1016/j.jocd.2015.04.009DOI Listing
January 2016

Lean mass and fat mass have differing associations with bone microarchitecture assessed by high resolution peripheral quantitative computed tomography in men and women from the Hertfordshire Cohort Study.

Bone 2015 Dec 15;81:145-151. Epub 2015 Jul 15.

MRC Lifecourse Epidemiology Unit, University of Southampton, Southampton General Hospital, Southampton SO16 6YD, UK; NIHR Musculoskeletal Biomedical Research Unit, Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Science, University of Oxford, Oxford OX3 5UG, UK; NIHR Nutrition Biomedical Research Centre, University of Southampton and University Hospital Southampton NHS Trust, Southampton General Hospital, Southampton SO16 6YD, UK. Electronic address:

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http://dx.doi.org/10.1016/j.bone.2015.07.013DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4641321PMC
December 2015

The Association of Grip Strength With Severity and Duration of Parkinson's: A Cross-Sectional Study.

Neurorehabil Neural Repair 2015 Oct 4;29(9):889-96. Epub 2015 Feb 4.

University of Southampton, Southampton, UK University Hospital Southampton NHS Foundation Trust, Southampton, UK.

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http://dx.doi.org/10.1177/1545968315570324DOI Listing
October 2015

Television viewing, walking speed, and grip strength in a prospective cohort study.

Med Sci Sports Exerc 2015 Apr;47(4):735-42

1Strangeways Research Laboratory, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UNITED KINGDOM; 2Medical Research Council Epidemiology Unit, Institute of Metabolic Science, School of Clinical Medicine, University of Cambridge, Cambridge, UNITED KINGDOM; and 3Academic Geriatric Medicine, Medical Research Council Lifecourse Epidemiology Unit, Faculty of Medicine, University of Southampton, Southampton, UNITED KINGDOM.

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http://dx.doi.org/10.1249/MSS.0000000000000453DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5642351PMC
April 2015

The age-related increase in low-grade systemic inflammation (Inflammaging) is not driven by cytomegalovirus infection.

Aging Cell 2012 Oct 12;11(5):912-5. Epub 2012 Jul 12.

MRC-ARUK Centre for Musculoskeletal Ageing Research, School of Immunity and Infection, University of Birmingham, Birmingham, UK.

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http://dx.doi.org/10.1111/j.1474-9726.2012.00849.xDOI Listing
October 2012

No interactions between previously associated 2-hour glucose gene variants and physical activity or BMI on 2-hour glucose levels.

Authors:
Robert A Scott Audrey Y Chu Niels Grarup Alisa K Manning Marie-France Hivert Dmitry Shungin Anke Tönjes Ajay Yesupriya Daniel Barnes Nabila Bouatia-Naji Nicole L Glazer Anne U Jackson Zoltán Kutalik Vasiliki Lagou Diana Marek Laura J Rasmussen-Torvik Heather M Stringham Toshiko Tanaka Mette Aadahl Dan E Arking Sven Bergmann Eric Boerwinkle Lori L Bonnycastle Stefan R Bornstein Eric Brunner Suzannah J Bumpstead Soren Brage Olga D Carlson Han Chen Yii-Der Ida Chen Peter S Chines Francis S Collins David J Couper Elaine M Dennison Nicole F Dowling Josephine S Egan Ulf Ekelund Michael R Erdos Nita G Forouhi Caroline S Fox Mark O Goodarzi Jürgen Grässler Stefan Gustafsson Göran Hallmans Torben Hansen Aroon Hingorani John W Holloway Frank B Hu Bo Isomaa Karen A Jameson Ingegerd Johansson Anna Jonsson Torben Jørgensen Mika Kivimaki Peter Kovacs Meena Kumari Johanna Kuusisto Markku Laakso Cécile Lecoeur Claire Lévy-Marchal Guo Li Ruth J F Loos Valeri Lyssenko Michael Marmot Pedro Marques-Vidal Mario A Morken Gabriele Müller Kari E North James S Pankow Felicity Payne Inga Prokopenko Bruce M Psaty Frida Renström Ken Rice Jerome I Rotter Denis Rybin Camilla H Sandholt Avan A Sayer Peter Shrader Peter E H Schwarz David S Siscovick Alena Stancáková Michael Stumvoll Tanya M Teslovich Gérard Waeber Gordon H Williams Daniel R Witte Andrew R Wood Weijia Xie Michael Boehnke Cyrus Cooper Luigi Ferrucci Philippe Froguel Leif Groop W H Linda Kao Peter Vollenweider Mark Walker Richard M Watanabe Oluf Pedersen James B Meigs Erik Ingelsson Inês Barroso Jose C Florez Paul W Franks Josée Dupuis Nicholas J Wareham Claudia Langenberg

Diabetes 2012 May 13;61(5):1291-6. Epub 2012 Mar 13.

Medical Research Council Epidemiology Unit, Institute of Metabolic Science, Addenbrooke’s Hospital, Cambridge, UK.

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http://diabetes.diabetesjournals.org/content/61/5/1291.full.
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http://diabetes.diabetesjournals.org/lookup/doi/10.2337/db11
Publisher Site
http://dx.doi.org/10.2337/db11-0973DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3331745PMC
May 2012

Genome-wide association identifies nine common variants associated with fasting proinsulin levels and provides new insights into the pathophysiology of type 2 diabetes.

Authors:
Rona J Strawbridge Josée Dupuis Inga Prokopenko Adam Barker Emma Ahlqvist Denis Rybin John R Petrie Mary E Travers Nabila Bouatia-Naji Antigone S Dimas Alexandra Nica Eleanor Wheeler Han Chen Benjamin F Voight Jalal Taneera Stavroula Kanoni John F Peden Fabiola Turrini Stefan Gustafsson Carina Zabena Peter Almgren David J P Barker Daniel Barnes Elaine M Dennison Johan G Eriksson Per Eriksson Elodie Eury Lasse Folkersen Caroline S Fox Timothy M Frayling Anuj Goel Harvest F Gu Momoko Horikoshi Bo Isomaa Anne U Jackson Karen A Jameson Eero Kajantie Julie Kerr-Conte Teemu Kuulasmaa Johanna Kuusisto Ruth J F Loos Jian'an Luan Konstantinos Makrilakis Alisa K Manning María Teresa Martínez-Larrad Narisu Narisu Maria Nastase Mannila John Ohrvik Clive Osmond Laura Pascoe Felicity Payne Avan A Sayer Bengt Sennblad Angela Silveira Alena Stancáková Kathy Stirrups Amy J Swift Ann-Christine Syvänen Tiinamaija Tuomi Ferdinand M van 't Hooft Mark Walker Michael N Weedon Weijia Xie Björn Zethelius Halit Ongen Anders Mälarstig Jemma C Hopewell Danish Saleheen John Chambers Sarah Parish John Danesh Jaspal Kooner Claes-Göran Ostenson Lars Lind Cyrus C Cooper Manuel Serrano-Ríos Ele Ferrannini Tom J Forsen Robert Clarke Maria Grazia Franzosi Udo Seedorf Hugh Watkins Philippe Froguel Paul Johnson Panos Deloukas Francis S Collins Markku Laakso Emmanouil T Dermitzakis Michael Boehnke Mark I McCarthy Nicholas J Wareham Leif Groop François Pattou Anna L Gloyn George V Dedoussis Valeriya Lyssenko James B Meigs Inês Barroso Richard M Watanabe Erik Ingelsson Claudia Langenberg Anders Hamsten Jose C Florez

Diabetes 2011 Oct 26;60(10):2624-34. Epub 2011 Aug 26.

Atherosclerosis Research Unit, Department of Medicine Solna, Karolinska Institutet, Karolinska University Hospital Solna, Stockholm, Sweden.

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http://dx.doi.org/10.2337/db11-0415DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3178302PMC
October 2011

Detailed physiologic characterization reveals diverse mechanisms for novel genetic Loci regulating glucose and insulin metabolism in humans.

Diabetes 2010 May 25;59(5):1266-75. Epub 2010 Feb 25.

Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.

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http://dx.doi.org/10.2337/db09-1568DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2857908PMC
May 2010