Publications by authors named "Austin Smith"

99Publications

Cancer-Related Mutations Are Not Enriched in Naive Human Pluripotent Stem Cells.

Cell Stem Cell 2021 Jan 14;28(1):164-169.e2. Epub 2020 Dec 14.

Wellcome-MRC Cambridge Stem Cell Institute, Jeffrey Cheah Biomedical Centre, University of Cambridge, Cambridge, CB2 0AW, UK; Living Systems Institute, University of Exeter, Exeter, EX4 4QD, UK. Electronic address:

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January 2021

Capture of Mouse and Human Stem Cells with Features of Formative Pluripotency.

Cell Stem Cell 2020 Nov 24. Epub 2020 Nov 24.

Wellcome-MRC Cambridge Stem Cell Institute, Jeffrey Cheah Biomedical Centre, University of Cambridge, Cambridge CB2 0AW, UK; Department of Biochemistry, University of Cambridge, Cambridge CB2 1GA, UK; Living Systems Institute, University of Exeter, Exeter EX4 4QD, UK. Electronic address:

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November 2020

Cerebral Malaria in a Patient with Recent Travel to the Congo Presenting with Delirium: A Case Report.

Clin Pract Cases Emerg Med 2020 Nov;4(4):533-536

Vanderbilt University Medical Center, Department of Emergency Medicine, Nashville, Tennessee.

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November 2020

The Evolution of Ultrasound in Medicine: A Case Report of Point-of-care Ultrasound in the Self-diagnosis of Acute Appendicitis.

Clin Pract Cases Emerg Med 2020 Nov;4(4):527-529

Eastern Virginia Medical School, Department of Emergency Medicine, Norfolk, Virginia.

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November 2020

GMP-grade neural progenitor derivation and differentiation from clinical-grade human embryonic stem cells.

Stem Cell Res Ther 2020 09 18;11(1):406. Epub 2020 Sep 18.

Wellcome-MRC Cambridge Stem Cell Institute, Jeffrey Cheah Biomedical Centre; Department of Surgery, University of Cambridge, Cambridge, CB2 0AW, UK.

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September 2020

Spontaneous Isolated Celiac Artery Dissection: A Case Report.

Clin Pract Cases Emerg Med 2020 Aug;4(3):414-416

Indiana University School of Medicine, Department of Emergency Medicine, Indianapolis, Indiana.

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August 2020

Vitriolage by Sulfuric Acid: Unique Challenges and Considerations in Patient Resuscitation.

J Emerg Med 2020 Oct 15;59(4):e123-e126. Epub 2020 Aug 15.

Department of Emergency Medicine, Vanderbilt University Medical Center, Nashville, Tennessee.

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October 2020

Dynamic human MutSα-MutLα complexes compact mismatched DNA.

Proc Natl Acad Sci U S A 2020 07 25;117(28):16302-16312. Epub 2020 Jun 25.

Department of Chemistry, University of North Carolina, Chapel Hill, NC 27599;

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July 2020

Microfluidic platform for 3D cell culture with live imaging and clone retrieval.

Lab Chip 2020 07;20(14):2580-2591

Wellcome-MRC Cambridge Stem Cell Institute, Jeffrey Cheah Biomedical Centre, University of Cambridge, Puddicombe Way, Cambridge Biomedical Campus, Cambridge, CB2 0AW, UK.

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July 2020

Cryptococcal meningitis in an immunocompetent patient.

Am J Emerg Med 2020 11 6;38(11):2492.e1-2492.e3. Epub 2020 Jun 6.

Department of Emergency Medicine, Vanderbilt University Medical Center, 1313 21st Ave, South, 703 Oxford House, Nashville, TN 37232-4700, United States of America.

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November 2020

"Considerable unreimbursed medical care is delivered through electronic patient portals: a retrospective review".

J Am Acad Dermatol 2020 May 18. Epub 2020 May 18.

Department of Dermatology, University of Texas Southwestern Medical Center, Dallas, TX, USA. Electronic address:

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May 2020

Potentially Harmful Ionizing Radiation Exposure from Diagnostic Tests and Medical Procedures in Patients with Aneurysmal Subarachnoid Hemorrhage.

World Neurosurg 2020 08 5;140:e153-e160. Epub 2020 May 5.

Department of Anesthesiology, University of Kentucky, Lexington, Kentucky, USA. Electronic address:

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August 2020

Improved Patient Satisfaction Following Robotic-Assisted Total Knee Arthroplasty.

J Knee Surg 2019 Nov 15. Epub 2019 Nov 15.

Adult Reconstruction Program, Kentucky One Health, University of Louisville, Louisville, Kentucky.

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November 2019

Nursing Home Social Services and Post-Acute Care: Does More Qualified Staff Improve Behavioral Symptoms and Reduce Antipsychotic Drug Use?

J Am Med Dir Assoc 2020 03 20;21(3):388-394. Epub 2019 Sep 20.

Department of Family Science & Social Work, Miami University, Oxford, OH; Department of Economics, Miami University, Oxford, OH.

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March 2020

Runner With Abdominal Pain.

Ann Emerg Med 2019 10;74(4):491-508

Department of Emergency Medicine, Vanderbilt University Medical Center, Nashville, TN.

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October 2019

Posttraumatic Stress Disorder Symptoms Contribute to Staff Perceived Irritability, Anger, and Aggression After TBI in a Longitudinal Veteran Cohort: A VA TBI Model Systems Study.

Arch Phys Med Rehabil 2020 01 9;101(1):81-88. Epub 2019 Sep 9.

Mental Health and Behavioral Sciences, James A Haley Veterans' Hospital, Tampa, Florida, United States; Defense and Veterans Brain Injury Center, Tampa, Florida, United States; Department of Internal Medicine, Division of Pulmonary and Sleep Medicine, Morsani College of Medicine, University of South Florida, Tampa, Florida, United States.

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January 2020

In Vitro Recapitulation of Developmental Transitions in Human Neural Stem Cells.

Stem Cells 2019 11 24;37(11):1429-1440. Epub 2019 Aug 24.

Institute of Reconstructive Neurobiology, LIFE & BRAIN Center, University of Bonn School of Medicine & University Hospital Bonn, Bonn, Germany.

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November 2019

Using the Retrobulbar Spot Sign to Assist in Diagnosis and Management of Central Retinal Artery Occlusions.

J Ultrasound Med 2020 Jan 22;39(1):197-202. Epub 2019 Jun 22.

Department of Emergency Medicine, Vanderbilt University Medical Center, Nashville, Tennessee, USA.

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January 2020

ST Elevation in a Patient With Abdominal Pain.

Ann Emerg Med 2019 06;73(6):624-626

Department of Emergency Medicine, Vanderbilt University Medical Center, Nashville, TN.

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June 2019

Melanoma patient notification and treatment timelines.

Dermatol Online J 2019 Apr 15;25(4). Epub 2019 Apr 15.

Texas A&M College of Medicine, Temple, Texas. Email:

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April 2019

The Cell-Surface Marker Sushi Containing Domain 2 Facilitates Establishment of Human Naive Pluripotent Stem Cells.

Stem Cell Reports 2019 06 25;12(6):1212-1222. Epub 2019 Apr 25.

Wellcome-MRC Cambridge Stem Cell Institute, University of Cambridge, Cambridge CB2 1QR, UK. Electronic address:

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June 2019

Complementary Activity of ETV5, RBPJ, and TCF3 Drives Formative Transition from Naive Pluripotency.

Cell Stem Cell 2019 05 25;24(5):785-801.e7. Epub 2019 Apr 25.

Wellcome - MRC Cambridge Stem Cell Institute, University of Cambridge, Cambridge CB2 1QR, UK; Department of Molecular Biology, Faculty of Science, Radboud University, 6525GA Nijmegen, the Netherlands. Electronic address:

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May 2019

Capacitation of human naïve pluripotent stem cells for multi-lineage differentiation.

Development 2019 04 3;146(7). Epub 2019 Apr 3.

Wellcome-MRC Cambridge Stem Cell Institute, Cambridge CB2 1QR, United Kingdom

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April 2019

Defined conditions for propagation and manipulation of mouse embryonic stem cells.

Development 2019 03 26;146(6). Epub 2019 Mar 26.

Wellcome-MRC Cambridge Stem Cell Institute, University of Cambridge, Gleeson Building, Tennis Court Road, Cambridge CB2 1QR, UK

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March 2019

Sustainability Challenges in Peptide Synthesis and Purification: From R&D to Production.

J Org Chem 2019 04 22;84(8):4615-4628. Epub 2019 Mar 22.

Chemical Development , Boehringer Ingelheim Pharmaceuticals , Ridgefield , Connecticut 06877 , United States.

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April 2019

Altered Mental Status in the Emergency Department.

Semin Neurol 2019 02 11;39(1):5-19. Epub 2019 Feb 11.

Department of Emergency Medicine, Vanderbilt University School of Medicine, Nashville, Tennessee.

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February 2019

Woman With Hip Pain.

Ann Emerg Med 2019 02;73(2):203-205

Department of Emergency Medicine, Vanderbilt University Medical Center, Nashville, TN.

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February 2019

A common molecular logic determines embryonic stem cell self-renewal and reprogramming.

EMBO J 2019 01 27;38(1). Epub 2018 Nov 27.

Department of Molecular Medicine, University of Padua, Padua, Italy

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January 2019

Hypothenar Hammer Syndrome.

J Emerg Med 2019 Jan 9;56(1):105-106. Epub 2018 Nov 9.

Department of Emergency Medicine, Vanderbilt University Medical Center, Nashville, Tennessee.

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January 2019

Hemiballismus: An Activating Lesion.

J Emerg Med 2018 Dec 1;55(6):e153-e155. Epub 2018 Nov 1.

Department of Emergency Medicine, Vanderbilt University Medical Center, Nashville, Tennessee.

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December 2018

Coping with compliance during take-off and landing in the diamond dove (Geopelia cuneata).

PLoS One 2018 25;13(7):e0199662. Epub 2018 Jul 25.

Field Research Station at Fort Missoula, Division of Biological Sciences, University of Montana, Missoula, MT, United States of America.

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January 2019

Coping with compliance during take-off and landing in the diamond dove (Geopelia cuneata).

PLoS One 2018 25;13(7):e0199662. Epub 2018 Jul 25.

Field Research Station at Fort Missoula, Division of Biological Sciences, University of Montana, Missoula, MT, United States of America.

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January 2019

Construction Worker With Chest Pain.

Ann Emerg Med 2018 08;72(2):222-231

Department of Emergency Medicine, Vanderbilt University, Nashville, TN.

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August 2018

Locked-in syndrome responding to thrombolytic therapy.

Am J Emerg Med 2018 10 3;36(10):1928.e5-1928.e7. Epub 2018 Jul 3.

Department of Emergency Medicine, Vanderbilt University Medical Center, 1313 21st Ave, South, 703 Oxford House, Nashville, TN 37232-4700, United States of America. Electronic address:

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October 2018

Negative feedback via RSK modulates Erk-dependent progression from naïve pluripotency.

EMBO Rep 2018 08 12;19(8). Epub 2018 Jun 12.

Wellcome Trust-Medical Research Council Stem Cell Institute, University of Cambridge, Cambridge, UK

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August 2018

A 3-Year-Old With Sudden-Onset Anisocoria After Playing Outside.

Pediatr Emerg Care 2018 Jun;34(6):e111-e114

Department of Emergency Medicine, Vanderbilt University Medical Center, Nashville, TN Departments of Ophthalmology and Visual Sciences, Vanderbilt University Medical Center, Nashville, TN Department of Emergency Medicine, Vanderbilt University Medical Center, Nashville, TN Department of Emergency Medicine, Vanderbilt University Medical Center, Nashville, TN

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June 2018

Acute streptococcal meningitis presenting as bilateral conductive hearing loss.

Am J Emerg Med 2018 Jul 5;36(7):1324.e3-1324.e4. Epub 2018 Apr 5.

Department of Emergency Medicine, Vanderbilt University Medical Center, 1313 21(st) Avenue, South, 703 Oxford House, Nashville, TN 37232-4700. Electronic address:

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July 2018

Reviewing state-mandated training requirements for naloxone-dispensing pharmacists.

Res Social Adm Pharm 2019 02 5;15(2):222-225. Epub 2018 Apr 5.

Division of Social and Administrative Sciences, University of Wisconsin-Madison School of Pharmacy, USA.

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February 2019

The Healing Power of Words.

Authors:
Austin T Smith

J Emerg Med 2018 05 16;54(5):719-720. Epub 2018 Mar 16.

Department of Emergency Medicine, Vanderbilt University Medical Center, Nashville, Tennessee.

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May 2018

Love Transcends Disease.

Authors:
Austin T Smith

Acad Emerg Med 2018 Mar 9. Epub 2018 Mar 9.

Department of Emergency Medicine, Vanderbilt University Medical Center, Nashville, TN.

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March 2018

Male With Sore Throat.

Ann Emerg Med 2018 Feb 5;71(2):262-269. Epub 2018 Feb 5.

Department of Emergency Medicine, Vanderbilt University Medical Center, Nashville, TN.

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February 2018

Integrated analysis of single-cell embryo data yields a unified transcriptome signature for the human pre-implantation epiblast.

Development 2018 02 7;145(3). Epub 2018 Feb 7.

Wellcome Trust - Medical Research Council Stem Cell Institute, University of Cambridge, Tennis Court Road, Cambridge CB2 1QR, UK

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February 2018

Pluripotency Deconstructed.

Dev Growth Differ 2018 Jan 23;60(1):44-52. Epub 2018 Jan 23.

Wellcome Trust-MRC Cambridge Stem Cell Institute, University of Cambridge, Gleeson Building, Tennis Court Road, Cambridge, UK.

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January 2018

Esrrb Complementation Rescues Development of Nanog-Null Germ Cells.

Cell Rep 2018 01;22(2):332-339

MRC Centre for Regenerative Medicine, Institute for Stem Cell Research, School of Biological Sciences, University of Edinburgh, 5 Little France Drive, Edinburgh EH16 4UU, Scotland. Electronic address:

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January 2018

Acute Coronary Syndrome in Octogenarians: Expect the Unexpected.

J Emerg Med 2018 Feb 23;54(2):e27-e30. Epub 2017 Nov 23.

Department of Emergency Medicine, Vanderbilt University Medical Center, Nashville, Tennessee.

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February 2018

Gene Editing in Rat Embryonic Stem Cells to Produce In Vitro Models and In Vivo Reporters.

Stem Cell Reports 2017 10;9(4):1262-1274

Wellcome Trust-Medical Research Council Cambridge Stem Cell Institute, University of Cambridge, Tennis Court Road, Cambridge CB2 1QR, UK; Department of Biochemistry, University of Cambridge, Tennis Court Road, Cambridge CB2 1GA, UK. Electronic address:

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October 2017

Moral Distress and Associated Factors Among Baccalaureate Nursing Students: A Multisite Descriptive Study.

Nurs Educ Perspect 2017 Nov/Dec;38(6):313-319

About the Authors Lorretta Krautscheid, PhD, RN, CNE, is an assistant professor, University of Portland School of Nursing, Portland, Oregon. Deborah A. DeMeester, PhD, RN, CNE, is a clinical assistant professor and assistant dean for prelicensure programs, Indiana University School of Nursing, Indianapolis, Indiana. Valorie Orton, MS, RN, CNL, is an instructor of nursing, Seattle Pacific University, Seattle, Washington. Austin Smith, BSN, is a registered nurse for Providence Health Systems, Portland, Oregon. Conor Livingston, BSN, is a registered nurse for Swedish Hospital, Seattle, Washington. Susan M. McLennon, PhD, ANP-BC, is an associate professor, University of Tennessee, Knoxville, Tennessee. For more information, contact Dr. Krautscheid at

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July 2018

A conceptual and computational framework for modelling and understanding the non-equilibrium gene regulatory networks of mouse embryonic stem cells.

PLoS Comput Biol 2017 Sep 1;13(9):e1005713. Epub 2017 Sep 1.

York Centre for Complex Systems Analysis, University of York, York, United Kingdom.

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September 2017

Epigenetic resetting of human pluripotency.

Development 2017 08;144(15):2748-2763

Wellcome Trust - Medical Research Council Cambridge Stem Cell Institute, University of Cambridge, Cambridge CB2 1QR, UK

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August 2017

Chemical Tattoo Treatment Leading to Systemic Cobalt Hypersensitivity.

Skinmed 2017;15(3):221-222. Epub 2017 Jun 1.

Department of Dermatology, Medical College of Wisconsin, Milwaukee, WI;

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August 2019

NODAL Secures Pluripotency upon Embryonic Stem Cell Progression from the Ground State.

Stem Cell Reports 2017 07 29;9(1):77-91. Epub 2017 Jun 29.

Wellcome Trust - Medical Research Council Stem Cell Institute, University of Cambridge, Tennis Court Road, Cambridge CB2 1QR, UK; Department of Biochemistry, University of Cambridge, Tennis Court Road, Cambridge CB2 1GA, UK. Electronic address:

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July 2017

Humanizing the Patient: A Lesson I Learned From Pumbaa.

Authors:
Austin Smith

Ann Emerg Med 2017 Jul;70(1):96-97

Department of Emergency Medicine, Vanderbilt University Medical Center, Nashville, TN. Electronic address:

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July 2017

Cosolutes, Crowding, and Protein Folding Kinetics.

J Phys Chem B 2017 07 29;121(27):6527-6537. Epub 2017 Jun 29.

Department of Chemistry, ‡Department of Biochemistry and Biophysics, and §Lineberger Comprehensive Cancer Center, University of North Carolina , Chapel Hill, North Carolina 27599, United States.

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July 2017

The Art of Capturing Pluripotency: Creating the Right Culture.

Stem Cell Reports 2017 06;8(6):1457-1464

Wellcome Trust - Medical Research Council Stem Cell Institute, University of Cambridge, Tennis Court Road, Cambridge CB2 1QR, UK; Department of Biochemistry, University of Cambridge, Tennis Court Road, Cambridge CB2 1GA, UK. Electronic address:

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June 2017

"Living" dynamics of filamentous bacteria on an adherent surface under hydrodynamic exposure.

Biointerphases 2017 05 10;12(2):02C410. Epub 2017 May 10.

Department of Materials Science and Engineering, Bioengineering Program, Lehigh University, Bethlehem, Pennsylvania 18015.

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May 2017

Formative pluripotency: the executive phase in a developmental continuum.

Authors:
Austin Smith

Development 2017 02;144(3):365-373

Wellcome Trust-Medical Research Council Stem Cell Institute and Department of Biochemistry, University of Cambridge, Tennis Court Road, Cambridge CB2 1QR, UK

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February 2017

Cardiac Tamponade Diagnosed by Point-of-Care Ultrasound.

Pediatr Emerg Care 2017 Feb;33(2):132-134

From the *Department of Emergency Medicine, †Division of Pediatric Emergency Medicine, Department of Pediatrics, and ‡Division of Emergency Ultrasound, Department of Emergency Medicine, Vanderbilt University Medical Center, Nashville, TN.

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February 2017

Primary Caregiver Perception of Pain Control following Pediatric Adenotonsillectomy: A Cross-Sectional Survey.

Otolaryngol Head Neck Surg 2016 11 6;155(5):869-875. Epub 2016 Sep 6.

Division of Otolaryngology-Head and Neck Surgery, University of Utah School of Medicine, Salt Lake City, Utah, USA

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November 2016

Infantile epidermolytic ichthyosis with prominent maternal palmoplantar keratoderma.

Dermatol Online J 2016 Apr 18;22(4). Epub 2016 Apr 18.

Scott & White Memorial Hospital and Clinic, Texas A&M University College of Medicine.

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April 2016

Delayed intracranial hemorrhage after head trauma in patients on direct-acting oral anticoagulants.

Am J Emerg Med 2017 Feb 15;35(2):377.e1-377.e2. Epub 2016 Aug 15.

Department of Emergency Medicine, Vanderbilt University Medical Center, Nashville, TN, USA. Electronic address:

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February 2017

Naive Pluripotent Stem Cells Derived Directly from Isolated Cells of the Human Inner Cell Mass.

Stem Cell Reports 2016 Apr 3;6(4):437-446. Epub 2016 Mar 3.

Wellcome Trust - Medical Research Council Stem Cell Institute, University of Cambridge, Tennis Court Road, Cambridge CB2 1QR, UK; Department of Physiology, Development and Neuroscience, University of Cambridge, Downing Street, Cambridge CB2 4BG, UK. Electronic address:

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April 2016

Myc Depletion Induces a Pluripotent Dormant State Mimicking Diapause.

Cell 2016 Feb;164(4):668-80

Division of Stem Cells and Cancer, Deutsches Krebsforschungszentrum (DKFZ), Im Neuenheimer Feld 280, 69120 Heidelberg, Germany; Heidelberg Institute for Stem Cell Technology and Experimental Medicine (HI-STEM gGmbH), Im Neuenheimer Feld 280, 69120 Heidelberg, Germany; German Cancer Consortium (DKTK), 69120 Heidelberg, Germany. Electronic address:

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February 2016

Protein Stability in Reverse Micelles.

Angew Chem Int Ed Engl 2016 Mar 8;55(11):3586-9. Epub 2016 Feb 8.

Department of Chemistry, University of North Carolina at Chapel Hill, Chapel Hill, NC, 27599-3290, USA.

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March 2016

Erratum to: Dynamics of gene silencing during X inactivation using allele-specific RNA-seq.

Genome Biol 2016 Feb 5;17:22. Epub 2016 Feb 5.

Radboud University, Faculty of Science, Department of Molecular Biology, Radboud Institute for Molecular Life Sciences (RIMLS), Nijmegen, 6500HB, The Netherlands.

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February 2016

In-cell thermodynamics and a new role for protein surfaces.

Proc Natl Acad Sci U S A 2016 Feb 11;113(7):1725-30. Epub 2016 Jan 11.

Department of Chemistry, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599; Department of Biochemistry and Biophysics, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599; Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599

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February 2016

Convergence of cMyc and β-catenin on Tcf7l1 enables endoderm specification.

EMBO J 2016 Feb 16;35(3):356-68. Epub 2015 Dec 16.

Wellcome Trust-Medical Research Council Cambridge Stem Cell Institute, University of Cambridge, Cambridge, UK Department of Biochemistry, University of Cambridge, Cambridge, UK

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February 2016

Lineage-Specific Profiling Delineates the Emergence and Progression of Naive Pluripotency in Mammalian Embryogenesis.

Dev Cell 2015 Nov;35(3):366-82

Wellcome Trust-Medical Research Council Stem Cell Institute, University of Cambridge, Tennis Court Road, Cambridge CB2 1QR, UK; European Bioinformatics Institute, European Molecular Biology Laboratory, Wellcome Trust Genome Campus, Cambridge CB10 1SD, UK; Genome Biology and Developmental Biology Units, European Molecular Biology Laboratory, Meyerhofstraße 1, 69117 Heidelberg, Germany. Electronic address:

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November 2015

Towards consistent generation of pancreatic lineage progenitors from human pluripotent stem cells.

Philos Trans R Soc Lond B Biol Sci 2015 Oct;370(1680):20140365

Wellcome Trust-Medical Research Council Stem Cell Institute, University of Cambridge, Tennis Court Road, Cambridge CB2 1QR, UK

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October 2015

Dynamics of gene silencing during X inactivation using allele-specific RNA-seq.

Genome Biol 2015 Aug 3;16:149. Epub 2015 Aug 3.

Radboud University, Faculty of Science, Department of Molecular Biology, Radboud Institute for Molecular Life Sciences (RIMLS), 6500HB, Nijmegen, The Netherlands.

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August 2015

Quinary structure modulates protein stability in cells.

Proc Natl Acad Sci U S A 2015 Feb 26;112(6):1739-42. Epub 2015 Jan 26.

Departments of Chemistry and Biochemistry and Biophysics and Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599

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February 2015

Hydrogen exchange of disordered proteins in Escherichia coli.

Protein Sci 2015 May 2;24(5):706-13. Epub 2015 Mar 2.

Department of Chemistry, University of North Carolina, Chapel Hill, North Carolina, 27599.

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May 2015

NMR studies of protein folding and binding in cells and cell-like environments.

Curr Opin Struct Biol 2015 Feb 3;30:7-16. Epub 2014 Dec 3.

Key Laboratory of Magnetic Resonance in Biological Systems, State Key Laboratory of Magnetic Resonance and Atomic and Molecular Physics, National Center for Magnetic Resonance in Wuhan, Wuhan Institute of Physics and Mathematics, Chinese Academy of Sciences, Wuhan 430071, PR China. Electronic address:

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February 2015

Mapping the route from naive pluripotency to lineage specification.

Philos Trans R Soc Lond B Biol Sci 2014 Dec;369(1657)

Wellcome Trust-Medical Research Council Cambridge Stem Cell Institute, University of Cambridge, Tennis Court Road, Cambridge CB2 1QR, UK Department of Biochemistry, University of Cambridge, Tennis Court Road, Cambridge CB2 1QR, UK

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December 2014