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Center for Reproductive Medicine, Shandong University, National Research Center for Assisted Reproductive Technology and Reproductive Genetics, Key Laboratory of Reproductive Endocrinology of Ministry of Education, Jinan, Shandong 250001, China; Advanced Medical Research Institute, Shandong University, Jinan, Shandong 250014, China; State Key Laboratory of Microbial Technology, Shandong University, Qingdao 266237, China. Electronic address: