Aurelien de Reyniès

Aurelien de Reyniès

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Aurelien de Reyniès

Aurelien de Reyniès

Publications by authors named "Aurelien de Reyniès"

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Unraveling the cellular heterogeneity of malignant pleural mesothelioma through a deconvolution approach.

Mol Cell Oncol 2019 7;6(4):1610322. Epub 2019 May 7.

Centre de Recherche des Cordeliers, Sorbonne Universités, Inserm, Paris, France.

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http://dx.doi.org/10.1080/23723556.2019.1610322DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6548486PMC
May 2019

Assessing reproducibility of matrix factorization methods in independent transcriptomes.

Bioinformatics 2019 Apr 2. Epub 2019 Apr 2.

Institut Curie, PSL Research University, Paris, France.

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http://dx.doi.org/10.1093/bioinformatics/btz225DOI Listing
April 2019

Mutational Profile of Aggressive, Localised Prostate Cancer from African Caribbean Men Versus European Ancestry Men.

Eur Urol 2019 01 21;75(1):11-15. Epub 2018 Sep 21.

CeRePP, Paris, France; Sorbonne Université, GRC n(∘)5, ONCOTYPE-URO, Paris, France; Assistance Publique Hôpitaux de Paris, Department of Urology, Academic Hospital Paris Est, Paris, France. Electronic address:

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http://dx.doi.org/10.1016/j.eururo.2018.08.026DOI Listing
January 2019

Prognostic Biomarkers in Pancreatic Cancer: Avoiding Errata When Using the TCGA Dataset.

Cancers (Basel) 2019 Jan 21;11(1). Epub 2019 Jan 21.

INSERM U1149, Beaujon University Hospital, 92110 Clichy, France.

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http://dx.doi.org/10.3390/cancers11010126DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6357157PMC
January 2019

Machine Learning for Better Prognostic Stratification and Driver Gene Identification Using Somatic Copy Number Variations in Anaplastic Oligodendroglioma.

Oncologist 2018 12 17;23(12):1500-1510. Epub 2018 Jul 17.

Sorbonne Université, INSERM U1127, CNRS UMR7225, Institut du Cerveau et de la Moelle épinière (ICM), AP-HP, Hôpitaux Universitaires La Pitié Salpêtrière - Charles Foix, Service de Neurologie 2-Mazarin, Paris, France

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http://dx.doi.org/10.1634/theoncologist.2017-0495DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6292528PMC
December 2018

Stratification of Pancreatic Ductal Adenocarcinomas Based on Tumor and Microenvironment Features.

Gastroenterology 2018 12 27;155(6):1999-2013.e3. Epub 2018 Aug 27.

Laboratory of Experimental Gastroenterology, Université Libre de Bruxelles, Brussels, Belgium; Department of Gastroenterology and Digestive Oncology, Erasme Hospital, Brussels, Belgium.

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http://dx.doi.org/10.1053/j.gastro.2018.08.033DOI Listing
December 2018

How Bad Is the Hedgehog? GLI-Dependent, Hedgehog-Independent Cancers on the Importance of Biomarkers for Proper Patients Selection.

J Investig Dermatol Symp Proc 2018 Dec;19(2):S87-S88

Institut Curie, Centre de Recherche, Team TGF-β and Oncogenesis, Orsay, France; Institut National de la Santé et de la Recherche Médicale, Unit U1021, Orsay, France; Le Centre National de la Recherche Scientifique, Unités Mixtes de Recherche 3347, Orsay, France. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S10870024183001
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http://dx.doi.org/10.1016/j.jisp.2018.09.010DOI Listing
December 2018

Molecular Subtypes of Clear-cell Renal Cell Carcinoma are Prognostic for Outcome After Complete Metastasectomy.

Eur Urol 2018 10 17;74(4):474-480. Epub 2018 Feb 17.

Laboratory of Experimental Oncology, Department of Oncology, KU Leuven, Leuven, Belgium; Inserm, UMR-1162, Génomique Fonctionnelle des Tumeurs Solides, IUH, Paris, France; Department of General Medical Oncology, University Hospitals Leuven, Leuven Cancer Institute, Leuven, Belgium. Electronic address:

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http://dx.doi.org/10.1016/j.eururo.2018.01.042DOI Listing
October 2018

Polymorphisms in the Von Hippel-Lindau Gene Are Associated With Overall Survival in Metastatic Clear-Cell Renal-Cell Carcinoma Patients Treated With VEGFR Tyrosine Kinase Inhibitors.

Clin Genitourin Cancer 2018 08 5;16(4):266-273. Epub 2018 Feb 5.

Laboratory of Experimental Oncology, Department of Oncology, University of Leuven, Leuven, Belgium; Department of General Medical Oncology, University Hospitals Leuven, Leuven Cancer Institute, Leuven, Belgium. Electronic address:

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http://dx.doi.org/10.1016/j.clgc.2018.01.013DOI Listing
August 2018

Transcriptomic analysis of the tumor microenvironment to guide prognosis and immunotherapies.

Cancer Immunol Immunother 2018 06 7;67(6):981-988. Epub 2017 Sep 7.

INSERM, UMR_S 1138, Cordeliers Research Center, Team Cancer, Immune Control and Escape, 75006, Paris, France.

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http://dx.doi.org/10.1007/s00262-017-2058-zDOI Listing
June 2018

Molecular Subtypes of Clear Cell Renal Cell Carcinoma Are Associated With Outcome During Pazopanib Therapy in the Metastatic Setting.

Clin Genitourin Cancer 2018 06 7;16(3):e605-e612. Epub 2017 Nov 7.

Laboratory of Experimental Oncology, Department of Oncology, University of Leuven, Leuven, Belgium; Department of General Medical Oncology, University Hospitals Leuven, Leuven Cancer Institute, Leuven, Belgium; Inserm, UMR-1162, Génomique fonctionnelle des tumeurs solides, Institut Universitaire Hématologie, Paris, France. Electronic address:

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http://dx.doi.org/10.1016/j.clgc.2017.10.017DOI Listing
June 2018

The Balance Between Cytotoxic T-cell Lymphocytes and Immune Checkpoint Expression in the Prognosis of Colon Tumors.

J Natl Cancer Inst 2018 01;110(1)

Programme "Cartes d'Identité des Tumeurs," Ligue Nationale Contre le Cancer, Paris, France; INSERM, UMRS 938 - Centre de Recherche Saint-Antoine, Equipe "Instabilité des Microsatellites et Cancers," Equipe labellisée par la Ligue Nationale contre le Cancer, Paris, France; Sorbonne Université, UPMC Univ Paris 06, Paris, France; AP-HP, Hôpital Saint-Antoine, Service d'Anatomie et Cytologie Pathologiques, Paris, France; Centre de Recherche en Cancérologie de Toulouse, UMR 1037 INSERM - Université Toulouse III, Department of Pathology, CHU, Toulouse, France; Laboratoire d'Oncopharmacologie, EA 3836, Centre Antoine Lacassagne, Nice, France; INSERM, U682, Développement et Physiopathologie de l'Intestin et du Pancréas, Strasbourg, France; AP-HP, Hôpital Saint-Antoine, Service d'Oncologie Médicale, Paris, France; AP-HP, Laboratoire d'oncogénétique et d'Angiogénétique, GH Pitié-Salpétrière, Paris, France; INSERM, Unité Mixte de Recherche, Paris Sorbonne Cité, Université Paris Descartes, Paris, France; Aix Marseille Univ, INSERM, GMGF, Marseille, France and RGDS, HP Clairval, Marseille, France; AP-HP, Service de Chirurgie Générale et Digestive, Hôpital Saint-Antoine, Paris, France; Department of Oncologic Medicine, Gustave-Roussy, Villejuif, France; Université Paris Descartes, Paris Sorbonne Cité INSERM UMR-S775, Paris, France; INSERM, Burgundy Cancer Registry, U866, Burgundy University, Dijon University Hospital, BP 87900?21079 Dijon, France; Department of Medical Oncology, Centre Georges-François Leclerc, Dijon, France; INSERM, UMR866, Burgundy University; Platform of transfer in oncology, Burgundy University, Centre Georges-François Leclerc, Dijon, France.

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http://dx.doi.org/10.1093/jnci/djx136DOI Listing
January 2018

Combined tumor genomic profiling and exome sequencing in a breast cancer family implicates ATM in tumorigenesis: A proof of principle study.

Genes Chromosomes Cancer 2017 11 16;56(11):788-799. Epub 2017 Aug 16.

INSERM U1218, Mammary & Leukemic Oncogenesis group, Université de Bordeaux, Bordeaux, France.

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http://dx.doi.org/10.1002/gcc.22482DOI Listing
November 2017

Co-occurring Mutations of Tumor Suppressor Genes, and , in Malignant Pleural Mesothelioma.

Clin Cancer Res 2017 Jun 21;23(12):3191-3202. Epub 2016 Dec 21.

Génomique Fonctionnelle des Tumeurs Solides, INSERM, UMR-1162, Equipe labellisée Ligue Contre le Cancer, Paris, France.

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http://dx.doi.org/10.1158/1078-0432.CCR-16-1971DOI Listing
June 2017

Immune Contexture, Immunoscore, and Malignant Cell Molecular Subgroups for Prognostic and Theranostic Classifications of Cancers.

Adv Immunol 2016 29;130:95-190. Epub 2016 Jan 29.

INSERM UMR_S 1138, Cancer, Immune Control and Escape, Cordeliers Research Centre, Paris, France; Université Paris-Descartes, Sorbonne Paris Cité, UMR_S 1338, Cordeliers Research Centre, Paris, France; Sorbonne Universités, UPMC Univ Paris 06, UMR_S 1138, Cordeliers Research Centre, Paris, France. Electronic address:

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http://dx.doi.org/10.1016/bs.ai.2015.12.002DOI Listing
October 2016

Immune and Stromal Classification of Colorectal Cancer Is Associated with Molecular Subtypes and Relevant for Precision Immunotherapy.

Clin Cancer Res 2016 Aug 18;22(16):4057-66. Epub 2016 Mar 18.

INSERM UMR_S 1138, Cancer, Immune Control and Escape, Cordeliers Research Centre, Paris, France. Université Paris Descartes, Paris, France. Université Pierre et Marie Curie, Paris, France.

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http://dx.doi.org/10.1158/1078-0432.CCR-15-2879DOI Listing
August 2016

Gene Expression Profiling of Muscle Stem Cells Identifies Novel Regulators of Postnatal Myogenesis.

Front Cell Dev Biol 2016 21;4:58. Epub 2016 Jun 21.

Institut Mondor de Recherche Biomédicale, INSERM U955-E10Créteil, France; Université Paris Est, Faculté de MedecineCréteil, France; Ecole Nationale Veterinaire d'AlfortMaison Alfort, France; Etablissement Français du SangCréteil, France; APHP, Hopitaux Universitaires Henri Mondor, DHU Pepsy and Centre de Référence des Maladies Neuromusculaires GNMHCréteil, France.

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http://dx.doi.org/10.3389/fcell.2016.00058DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4914952PMC
July 2016

Prognostic and theranostic impact of molecular subtypes and immune classifications in renal cell cancer (RCC) and colorectal cancer (CRC).

Oncoimmunology 2015 Dec 7;4(12):e1049804. Epub 2015 Aug 7.

INSERM UMR_S 1138 Cancer; Immune Control and Escape; Cordeliers Research Centre ; Paris, France ; Université Paris Descartes; Sorbonne Paris Cité; UMR_S 1338; Cordeliers Research Centre ; Paris, France ; Sorbonne Universités; UPMC Univ Paris 06; UMR_S 1138; Cordeliers Research Centre ; Paris, France ; Assistance Publique-Hôpitaux de Paris; Hôpital Européen Georges Pompidou, Department of Biology , Paris, France.

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http://dx.doi.org/10.1080/2162402X.2015.1049804DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4635888PMC
December 2015

Integrating tumor microenvironment with cancer molecular classifications.

Genome Med 2015 Nov 14;7(1):115. Epub 2015 Nov 14.

INSERM UMR_S 1138, Cancer, Immune Control and Escape, Cordeliers Research Centre, Paris, France.

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http://dx.doi.org/10.1186/s13073-015-0241-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4644274PMC
November 2015

Sporadic early-onset colorectal cancer is a specific sub-type of cancer: a morphological, molecular and genetics study.

PLoS One 2014 1;9(8):e103159. Epub 2014 Aug 1.

Centre de Recherche en Cancérologie de Toulouse, Unité Mixte de Recherche, 1037 INSERM - Université Toulouse III, Toulouse, France; Department of Pathology, Centre Hospitalier Universitaire de Toulouse, Toulouse, France.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0103159PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4118858PMC
April 2015

Molecular subtypes of clear cell renal cell carcinoma are associated with sunitinib response in the metastatic setting.

Clin Cancer Res 2015 Mar 12;21(6):1329-39. Epub 2015 Jan 12.

Inserm, UMR-1162, Génomique fonctionnelle des tumeurs solides, Paris, France. Université Paris Descartes, Sorbonne Paris Cité, Faculté de Médecine, Paris, France. Labex Immuno-oncology, Paris, France. Assistance Publique-Hôpitaux de Paris, Hôpital Européen Georges Pompidou, Department of Oncology, Paris, France.

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http://dx.doi.org/10.1158/1078-0432.CCR-14-1128DOI Listing
March 2015

Multi-omics analysis defines core genomic alterations in pheochromocytomas and paragangliomas.

Nat Commun 2015 Jan 27;6:6044. Epub 2015 Jan 27.

1] INSERM, UMR970, Paris-Cardiovascular Research Center, F-75015 Paris, France [2] Université Paris Descartes, Sorbonne Paris Cité, Faculté de Médecine, F-75006 Paris, France [3] Department of Genetics, Assistance Publique-Hôpitaux de Paris, Hôpital Européen Georges Pompidou, F-75015 Paris, France [4] Rare Adrenal Cancer Network COMETE, F-75006 Paris, France.

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http://dx.doi.org/10.1038/ncomms7044DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4354166PMC
January 2015

Clearance of PML/RARA-bound promoters suffice to initiate APL differentiation.

Blood 2014 Dec 25;124(25):3772-80. Epub 2014 Sep 25.

Université Paris Diderot, Sorbonne Paris Cité, Paris, France; INSERM Unité Mixte de Recherche 944, Equipe Labellisée par la Ligue Nationale contre le Cancer, Institut Universitaire d'Hématologie, Paris, France; Centre National de la Recherche Scientifique, Unité Mixte de Recherche 7212, Hôpital St. Louis, Paris, France; Assistance Publique-Hôpitaux de Paris, Service de Biochimie, Hôpital St. Louis, Paris, France; and Collège de France, Paris, France.

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http://dx.doi.org/10.1182/blood-2014-03-561852DOI Listing
December 2014

Lung squamous cell carcinomas with basaloid histology represent a specific molecular entity.

Clin Cancer Res 2014 Nov 4;20(22):5777-86. Epub 2014 Sep 4.

Département d'Anatomie et Cytologie Pathologique, Centre Hospitalier Universitaire de Grenoble, Institut Albert Bonniot, INSERM U823, Université Joseph Fourrier, Grenoble, France.

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http://dx.doi.org/10.1158/1078-0432.CCR-14-0459DOI Listing
November 2014

Independent component analysis uncovers the landscape of the bladder tumor transcriptome and reveals insights into luminal and basal subtypes.

Cell Rep 2014 Nov 13;9(4):1235-45. Epub 2014 Nov 13.

Institut Curie, Centre de Recherche, 75248 cedex 05 Paris, France; CNRS, UMR 144, Oncologie Moléculaire, Equipe Labellisée Ligue Contre le Cancer, Institut Curie, 75248 cedex 05 Paris, France. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2014.10.035DOI Listing
November 2014

High-resolution analysis of DNA copy number alterations in rectal cancer: correlation with metastasis, survival, and mRNA expression.

Strahlenther Onkol 2014 Oct 26;190(11):1028-36. Epub 2014 Apr 26.

Department of Radiation Oncology, Centre Antoine-Lacassagne, 33 avenue de Valombrose, 06189, Nice, France,

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http://dx.doi.org/10.1007/s00066-014-0659-4DOI Listing
October 2014

Integrated genomic characterization of adrenocortical carcinoma.

Nat Genet 2014 Jun 20;46(6):607-12. Epub 2014 Apr 20.

1] INSERM U1016, Institut Cochin, Paris, France. [2] CNRS UMR 8104, Paris, France. [3] Université Paris Descartes, Sorbonne Paris Cité, Paris, France. [4] Center for Rare Adrenal Diseases, Department of Endocrinology, Assistance Publique-Hôpitaux de Paris, Hôpital Cochin, Paris, France. [5] Rare Adrenal Cancer Network COMETE, Paris, France. [6].

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http://dx.doi.org/10.1038/ng.2953DOI Listing
June 2014

Molecular classification of malignant pleural mesothelioma: identification of a poor prognosis subgroup linked to the epithelial-to-mesenchymal transition.

Clin Cancer Res 2014 Mar 17;20(5):1323-34. Epub 2014 Jan 17.

Authors' Affiliations: Ligue Nationale Contre Le Cancer, Programme Cartes d'Identité des Tumeurs (CIT); INSERM, UMR-1162, Génomique fonctionnel des tumeurs solides, IUH; Université Paris Descartes; Université Paris Diderot; Université Paris 13; Labex Immuno-Oncology; Sorbonne Paris Cité; AP-HP, GHU Ouest, Hôpital Européen Georges Pompidou, Laboratoire d'Anatomie Pathologique; AP-HP, GHU Ouest, Hôpital Européen Georges Pompidou, Service de Chirurgie Thoracique, Paris; CHRU Lille, Service de Chirurgie Cardiaque; CHRU Lille, Université de Lille II, Institut de Pathologie, Centre de Biologie-Pathologie, 59037 Lille; CHU Caen, Service d'Anatomo-Pathologie; INSERM, U1086, Caen; CHU Nice, Laboratoire de Pathologie Clinique et Expérimentale (LPCE) et Biobanque Humaine, Hôpital Pasteur, Nice; Centre Hospitalier Intercommunal de Créteil, Service de Pneumologie et de Pathologie Professionnelle; and INSERM, U955, Equipe 4, Créteil, France.

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http://dx.doi.org/10.1158/1078-0432.CCR-13-2429DOI Listing
March 2014

Activation of a promyelocytic leukemia-tumor protein 53 axis underlies acute promyelocytic leukemia cure.

Nat Med 2014 Feb 12;20(2):167-74. Epub 2014 Jan 12.

1] Université Paris Diderot, Sorbonne Paris Cité, Hôpital St. Louis, Paris, France. [2] INSERM UMR 944, Equipe Labellisée par la Ligue Nationale contre le Cancer, Institut Universitaire d'Hématologie, Hôpital St. Louis, Paris, France. [3] CNRS UMR 7212, Hôpital St. Louis, Paris, France. [4] Assistance Publique Hôpitaux de Paris, Service de Biochimie, Hôpital St. Louis, Paris, France.

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http://www.nature.com/articles/nm.3441
Publisher Site
http://dx.doi.org/10.1038/nm.3441DOI Listing
February 2014

A poor prognosis subtype of HNSCC is consistently observed across methylome, transcriptome, and miRNome analysis.

Clin Cancer Res 2013 Aug 11;19(15):4174-84. Epub 2013 Jun 11.

EA3430, Laboratoire de Biologie Tumorale, Centre Régional de Lutte Contre le Cancer Paul Strauss, 3 Rue de la Porte de l'Hôpital, Strasbourg, France.

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http://dx.doi.org/10.1158/1078-0432.CCR-12-3690DOI Listing
August 2013

A hepatocellular carcinoma 5-gene score associated with survival of patients after liver resection.

Gastroenterology 2013 Jul 6;145(1):176-187. Epub 2013 Apr 6.

Inserm, UMR-674, Génomique Fonctionnelle des Tumeurs Solides, IUH, Paris, France; Université Paris Descartes, Labex Immuno-Oncology, Sorbonne Paris Cité, Faculté de Médecine, Paris, France; Assistance Publique-Hôpitaux de Paris, Hôpital Européen Georges Pompidou, Paris, France. Electronic address:

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http://dx.doi.org/10.1053/j.gastro.2013.03.051DOI Listing
July 2013

Identification of gene expression profiles associated with cortisol secretion in adrenocortical adenomas.

J Clin Endocrinol Metab 2013 Jun 28;98(6):E1109-21. Epub 2013 Mar 28.

Institut National de la Santé et de la Recherche Médicale Unité 1016, 75014 Paris, France.

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http://dx.doi.org/10.1210/jc.2012-4237DOI Listing
June 2013

CD8-alpha T-cell infiltration in human papillomavirus-related oropharyngeal carcinoma correlates with improved patient prognosis.

Int J Cancer 2013 Jan 1;132(2):E26-36. Epub 2012 Sep 1.

Laboratoire de Biologie Tumorale, EA3430, Centre Régional de Lutte Contre le Cancer Paul Strauss, 3 Rue de la Porte de l'Hôpital, Strasbourg, France.

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http://dx.doi.org/10.1002/ijc.27776DOI Listing
January 2013

Identification of a CpG island methylator phenotype in adrenocortical carcinomas.

J Clin Endocrinol Metab 2013 Jan 23;98(1):E174-84. Epub 2012 Oct 23.

Institut National de la Santé et de la Recherche Médicale Unité 1016, Centre National de la Recherche Scientifique Unité Mixte de Recherche 8104, Assistance Publique Hôpitaux de Paris, Hôpital Cochin, 75014 Paris, France.

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http://dx.doi.org/10.1210/jc.2012-2993DOI Listing
January 2013

Methylation profiling identifies 2 groups of gliomas according to their tumorigenesis.

Neuro Oncol 2011 Jan 5;13(1):84-98. Epub 2010 Oct 5.

Université Pierre et Marie Curie-Paris 6, Centre de Recherche de l'Institut du Cerveau et de la Moëlle épinière (CRICM) UMR-S975, 75013 Paris, France.

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http://dx.doi.org/10.1093/neuonc/noq110DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3018904PMC
January 2011

Stem cell-like micro-RNA signature driven by Myc in aggressive liver cancer.

Proc Natl Acad Sci U S A 2010 Nov 8;107(47):20471-6. Epub 2010 Nov 8.

Oncogenesis and Molecular Virology Unit, Institut Pasteur, 75015 Paris, France.

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http://dx.doi.org/10.1073/pnas.1009009107DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2996672PMC
November 2010

Cyclooxygenase-2 inhibitors down-regulate osteopontin and Nr4A2-new therapeutic targets for colorectal cancers.

Gastroenterology 2009 Oct 21;137(4):1358-66.e1-3. Epub 2009 Jun 21.

Institut Cochin, Université Paris Descartes, Centre National de la Recherche Scientifique (UMR 8104), Paris, France.

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http://linkinghub.elsevier.com/retrieve/pii/S001650850900932
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http://dx.doi.org/10.1053/j.gastro.2009.06.039DOI Listing
October 2009

Gene expression profiling reveals a new classification of adrenocortical tumors and identifies molecular predictors of malignancy and survival.

J Clin Oncol 2009 Mar 12;27(7):1108-15. Epub 2009 Jan 12.

Service des Maladies Endocriniennes et Métaboliques, Hôpital Cochin, 27, rue du Faubourg Saint-Jacques, 75014, Paris, France.

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http://dx.doi.org/10.1200/JCO.2008.18.5678DOI Listing
March 2009

Stabilization of beta-catenin affects mouse embryonic liver growth and hepatoblast fate.

Hepatology 2008 Jan;47(1):247-58

Institut Cochin, Université Paris Descartes, Centre National de la Recherche Scientifique (UMR 8104), Paris, France.

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http://dx.doi.org/10.1002/hep.21952DOI Listing
January 2008