Auli Karhu

Auli Karhu

UNVERIFIED PROFILE

Are you Auli Karhu?   Register this Author

Register author
Auli Karhu

Auli Karhu

Publications by authors named "Auli Karhu"

Are you Auli Karhu?   Register this Author

63Publications

1366Reads

11Profile Views

Genetic and epigenetic characterization of growth hormone - secreting pituitary tumors.

Mol Cancer Res 2019 Oct 2. Epub 2019 Oct 2.

Department of Medical and Clinical Genetics, University of Helsinki

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1158/1541-7786.MCR-19-0434DOI Listing
October 2019

Screening for germline and mutations in a set of somatotropinoma patients.

Endocr Connect 2018 May;7(5):645-652

Institute of Biomedicine/PhysiologyBiomedicum Helsinki, University of Helsinki, Helsinki, Finland

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1530/EC-18-0123DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5931228PMC
May 2018

Global metabolomic profiling of uterine leiomyomas.

Br J Cancer 2017 Dec 26;117(12):1855-1864. Epub 2017 Oct 26.

Division of Functional Genomics, Department of Medical Biochemistry and Biophysics, Karolinska Institutet, Scheeles Väg 2, Stockholm SE-17177, Sweden.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/bjc.2017.361DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5729474PMC
December 2017

Impact of AIP and inhibitory G protein alpha 2 proteins on clinical features of sporadic GH-secreting pituitary adenomas.

Eur J Endocrinol 2017 Feb;176(2):243-252

Department of Medical and Clinical Genetics & Genome-Scale BiologyResearch Programs Unit, University of Helsinki, Helsinki, Finland

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1530/EJE-16-0620DOI Listing
February 2017

Mild pituitary phenotype in 3- and 12-month-old Aip-deficient male mice.

J Endocrinol 2016 10;231(1):59-69

Institut National de la Santé et de la Recherche Médicale (Inserm) U1185Le Kremlin-Bicêtre, France Université Paris-SudFaculté de Médecine Paris-Sud, Le Kremlin-Bicêtre, France Assistance Publique-Hôpitaux de ParisService d'Endocrinologie et des Maladies de la Reproduction, Hôpital Bicêtre, Le Kremlin Bicêtre, France

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1530/JOE-16-0190DOI Listing
October 2016

Mutation analysis of inhibitory guanine nucleotide binding protein alpha (GNAI) loci in young and familial pituitary adenomas.

PLoS One 2014 7;9(10):e109897. Epub 2014 Oct 7.

Department of Medical Genetics, Genome-Scale Biology Research Program, Institute of Biomedicine, Biomedicum Helsinki, University of Helsinki, Helsinki, Finland.

View Article

Download full-text PDF

Source
http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0109897PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4188600PMC
December 2015

Whole-Genome Sequencing of Growth Hormone (GH)-Secreting Pituitary Adenomas.

J Clin Endocrinol Metab 2015 Oct 17;100(10):3918-27. Epub 2015 Aug 17.

Department of Medical and Clinical Genetics (N.V.,H.D., E.P., E.K., L.A.A., A.Karh.), Genome-Scale Biology Research Programs Unit (N.V., H.D., E.P., E.K., L.A.A., A.Karh.), University of Helsinki, 00014 Helsinki, Finland; and Department of Neurosurgery (A.Karp., L.K.), Helsinki University Central Hospital, and Department of Endocrinology (C.S.-J.), Abdominal Center, University of Helsinki and Helsinki University Central Hospital, 00029 Helsinki, Finland.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1210/jc.2015-3129DOI Listing
October 2015

Clinical characterization, genetic mapping and whole-genome sequence analysis of a novel autosomal recessive intellectual disability syndrome.

Eur J Med Genet 2014 Oct 29;57(10):543-51. Epub 2014 Jul 29.

Department of Medical Genetics, Genome-Scale Biology Research Program, University of Helsinki and Haartman Institute, Helsinki, Finland. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.ejmg.2014.07.002DOI Listing
October 2014

Familial isolated pituitary adenomas (FIPA) and the pituitary adenoma predisposition due to mutations in the aryl hydrocarbon receptor interacting protein (AIP) gene.

Endocr Rev 2013 Apr 31;34(2):239-77. Epub 2013 Jan 31.

Department of Endocrinology, Centre Hospitalier Universitaire de Liège, University of Liège, Domaine Universitaire du Sart-Tilman, 4000 Liège, Belgium.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1210/er.2012-1013DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3610678PMC
April 2013

Mice lacking a Myc enhancer that includes human SNP rs6983267 are resistant to intestinal tumors.

Science 2012 Dec 1;338(6112):1360-3. Epub 2012 Nov 1.

Science for Life Center, Department of Biosciences and Nutrition, Karolinska Institutet, Stockholm, Sweden.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1126/science.1228606DOI Listing
December 2012

No evidence of RET germline mutations in familial pituitary adenoma.

J Mol Endocrinol 2011 Feb 21;46(1):1-8. Epub 2010 Dec 21.

Genome-Scale Biology Research Program, Department of Medical Genetics, University of Helsinki, 00014 Helsinki, Finland.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1677/JME-10-0052DOI Listing
February 2011

Downregulation of the hedgehog receptor PTCH1 in colorectal serrated adenocarcinomas is not caused by PTCH1 mutations.

Virchows Arch 2011 Feb 14;458(2):213-9. Epub 2011 Jan 14.

Department of Pathology, Institute of Diagnostics, University of Oulu, FI-90014, Oulu, Finland.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s00428-010-1031-4DOI Listing
February 2011

Systematic search for enhancer elements and somatic allelic imbalance at seven low-penetrance colorectal cancer predisposition loci.

BMC Med Genet 2011 Feb 14;12:23. Epub 2011 Feb 14.

Department of Medical Genetics, Genome-Scale Biology Research Program, Biomedicum Helsinki, University of Helsinki, Helsinki, Finland.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/1471-2350-12-23DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3045878PMC
February 2011

Somatic mutations and germline sequence variants in patients with familial colorectal cancer.

Int J Cancer 2010 Dec;127(12):2974-80

Department of Medical Genetics, Genome-Scale Biology Research Program, Biomedicum Helsinki, University of Helsinki, Finland.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/ijc.25529DOI Listing
December 2010

Clinical characteristics and therapeutic responses in patients with germ-line AIP mutations and pituitary adenomas: an international collaborative study.

J Clin Endocrinol Metab 2010 Nov 4;95(11):E373-83. Epub 2010 Aug 4.

Department of Endocrinology, Centre Hospitalier Universitaire de Liège, University of Liège, Liège, Belgium.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1210/jc.2009-2556DOI Listing
November 2010

Low-penetrance susceptibility variants in familial colorectal cancer.

Cancer Epidemiol Biomarkers Prev 2010 Jun 25;19(6):1478-83. Epub 2010 May 25.

Department of Medical Genetics, Genome-Scale Biology Research Program, Biomedicum Helsinki, University of Helsinki, Helsinki, Finland.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1158/1055-9965.EPI-09-1320DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2883738PMC
June 2010

Aggressive pituitary adenomas occurring in young patients in a large Polynesian kindred with a germline R271W mutation in the AIP gene.

Eur J Endocrinol 2009 Nov 14;161(5):799-804. Epub 2009 Aug 14.

Department of Endocrinology and Diabetes and Centre for Hormone Research, The Murdoch Childrens Research Institute and The Royal Children's Hospital, Flemington Road, Parkville, Melbourne, Victoria 3052, Australia.

View Article

Download full-text PDF

Source
https://eje.bioscientifica.com/view/journals/eje/161/5/799.x
Publisher Site
http://dx.doi.org/10.1530/EJE-09-0406DOI Listing
November 2009

Large genomic deletions in AIP in pituitary adenoma predisposition.

J Clin Endocrinol Metab 2008 Oct 15;93(10):4146-51. Epub 2008 Jul 15.

Department of Medical Genetics, Biomedicum Helsinki, University of Helsinki, 00014 Helsinki, Finland.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1210/jc.2008-1003DOI Listing
October 2008

Somatic mutation analysis of MYH11 in breast and prostate cancer.

BMC Cancer 2008 Sep 17;8:263. Epub 2008 Sep 17.

Department of Medical Genetics and Translational Genome-Scale Biology Research Program, University of Helsinki, Helsinki, Finland.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/1471-2407-8-263DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2562392PMC
September 2008

A genome-wide association study identifies colorectal cancer susceptibility loci on chromosomes 10p14 and 8q23.3.

Nat Genet 2008 May 30;40(5):623-30. Epub 2008 Mar 30.

Molecular and Population Genetics Laboratory, London Research Institute, Cancer Research UK, London WC2A 3PX, UK.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/ng.111DOI Listing
May 2008

Unregulated smooth-muscle myosin in human intestinal neoplasia.

Proc Natl Acad Sci U S A 2008 Apr 7;105(14):5513-8. Epub 2008 Apr 7.

Department of Medical Genetics and Division of Pathology, HUSLAB and Haartman Institute, Helsinki University Central Hospital and Genome Scale Biology Program, Biomedicum Helsinki, University of Helsinki, 00014, Helsinki, Finland.

View Article

Download full-text PDF

Source
http://www.pnas.org/cgi/doi/10.1073/pnas.0801213105
Publisher Site
http://dx.doi.org/10.1073/pnas.0801213105DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2291082PMC
April 2008

Stress-induced expression of a novel variant of human fumarate hydratase (FH).

Gene Expr 2007 ;14(2):59-69

Department of Medical Genetics, Biomedicum Helsinki, University of Helsinki, Helsinki, Finland.

View Article

Download full-text PDF

Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6042040PMC
March 2008

Allelic imbalance at rs6983267 suggests selection of the risk allele in somatic colorectal tumor evolution.

Cancer Res 2008 Jan;68(1):14-7

Department of Medical Genetics, Genome-Scale Biology Research Program, Biomedicum Helsinki, University of Helsinki, P.O. Box 63, FIN-00014 Helsinki, Finland.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1158/0008-5472.CAN-07-5766DOI Listing
January 2008

Computational identification of candidate loci for recessively inherited mutation using high-throughput SNP arrays.

Bioinformatics 2007 Aug 17;23(15):1952-61. Epub 2007 May 17.

Computational Systems Biology Laboratory, Institute of Biomedicine, University of Helsinki, Finland.

View Article

Download full-text PDF

Source
https://academic.oup.com/bioinformatics/article-lookup/doi/1
Publisher Site
http://dx.doi.org/10.1093/bioinformatics/btm263DOI Listing
August 2007

AIP gene in pituitary adenoma predisposition.

Expert Rev Endocrinol Metab 2007 Jul;2(4):443-450

b Department of Medical Genetics, Genome-Scale Biology Research Program, PO Box 63 (Haartmaninkatu 8), FIN-00014 University of Helsinki, Helsinki, Finland.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1586/17446651.2.4.443DOI Listing
July 2007

Background mutation frequency in microsatellite-unstable colorectal cancer.

Cancer Res 2007 Jun;67(12):5691-8

Department of Medical Genetics, Biomedicum Helsinki, University of Helsinki, Finland.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1158/0008-5472.CAN-06-4314DOI Listing
June 2007

Susceptibility to pituitary neoplasia related to MEN-1, CDKN1B and AIP mutations: an update.

Hum Mol Genet 2007 Apr;16 Spec No 1:R73-9

Department of Medical Genetics, University of Helsinki, Helsinki, Finland.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1093/hmg/ddm036DOI Listing
April 2007

Preferential amplification of AURKA 91A (Ile31) in familial colorectal cancers.

Int J Cancer 2006 Jan;118(2):505-8

Department of Medical Genetics, Biomedicum Helsinki, University of Helsinki, Finland.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/ijc.21344DOI Listing
January 2006

A novel functionally deficient MYH variant in individuals with colorectal adenomatous polyposis.

Hum Mutat 2005 Oct;26(4):393

Department of Medical Genetics, Biomedicum Helsinki, University of Helsinki, Helsinki, Finland.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/humu.9368DOI Listing
October 2005

7q deletion mapping and expression profiling in uterine fibroids.

Oncogene 2005 Sep;24(43):6545-54

Department of Medical Genetics, University of Helsinki, PO Box 63 (Haartmaninkatu 8), Biomedicum Helsinki, FIN-00014, Finland.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/sj.onc.1208784DOI Listing
September 2005

NOD2 3020insC alone is not sufficient for colorectal cancer predisposition.

Cancer Res 2004 Oct;64(20):7245-7

Department of Medical Genetics, Biomedicum Helsinki, University of Helsinki, Helsinki, Finland.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1158/0008-5472.CAN-04-2364DOI Listing
October 2004

Little evidence for involvement of MLH3 in colorectal cancer predisposition.

Int J Cancer 2003 Aug;106(2):292-6

Department of Medical Genetics, Biomedicum Helsinki, University of Helsinki, Helsinki, Finland.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/ijc.11218DOI Listing
August 2003