Publications by authors named "Augusto L Souto"

2 Publications

  • Page 1 of 1

Prosopis juliflora as a new cosmetic ingredient: Development and clinical evaluation of a bioactive moisturizing and anti-aging innovative solid core.

Carbohydr Polym 2020 Apr 10;233:115854. Epub 2020 Jan 10.

Federal University of Rio Grande do Norte - UFRN, R. Gen. Gustavo Cordeiro de Faria, s/n - Petrópolis, Natal, RN, 59012-570, Brazil. Electronic address:

Prosopis juliflora is an invasive plant distributed throughout the world and presents metabolites of interest for cosmetology. The aim of this work was to develop a new polysaccharide-based ingredient from P. juliflora and analyze its application in a solid core formulation that upon contact with water instantly forms a gel to improve moisturizing and anti-aging skin properties. Purified extracts by gel chromatography were characterized by NMR and LC-DAD-MS-MS. The in vitro and in vivo safety, antioxidant activity, formulation development and clinical evaluation were performed. The extract was characterized as containing an α-glucan and phenolics. It was non-cytotoxic, non-phototoxic and no skin reactions were observed in vivo. Antioxidant activity were present through different mechanisms. Clinical evaluation reinforced the potential of P. juliflora in skin hydration and microrelief improvement. This innovative form proved to be a prototype of a new product and the first study of an α-glucan as a cosmetic ingredient.
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http://dx.doi.org/10.1016/j.carbpol.2020.115854DOI Listing
April 2020

Modulation of the antibiotic activity against multidrug resistant strains of coumarins isolated from Rutaceae species.

Microb Pathog 2017 Mar 19;104:151-154. Epub 2017 Jan 19.

Departamento de Ciências Farmacêuticas, Universidade Federal da Paraíba, João Pessoa, Brazil. Electronic address:

The first occurrences and dissemination of resistant microorganisms led to the inefficacy of many antibiotics, available in the market nowadays, therefore, the search for new substances with antimicrobial activity from natural sources has gained a great importance. The purpose of this work is to evaluate the antibacterial activity and modulation of drug resistance in Staphylococcus aureus by coumarins such as bergapten, xantotoxin, isopimpinellin and imperatorin obtained from two Rutaceae species (Metrodorea mollis and Pilocarpus spicatus). The antimicrobial activity was assessed based on the minimum inhibitory concentration (MIC), using the microdilution method. The MIC was >256 g/mL for all coumarins tested. Regarding the modulation of drug resistance assay, the isopimpinellin reducted the MIC of erytromicin by 4 times, whereas imperatorin exhibited the best result, reducing the MIC of tetracycline (2 times), erytomicin (4 times) and norfloxacin (4 times). By reducing the MIC of ethidium bromide, the imperatorin is consider in fact, as a putative efflux pump inhibitor of bacteria.
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http://dx.doi.org/10.1016/j.micpath.2017.01.028DOI Listing
March 2017