Dr. Atul Rawat, PhD - Babasaheb Bhimrao Ambedkar University

Dr. Atul Rawat

PhD

Babasaheb Bhimrao Ambedkar University

Lucknow, Uttar Pradesh | India

Main Specialties: Biotechnology, Endocrinology Diabetes & Metabolism, Infectious Disease, Medical Toxicology, Pharmacology, Pulmonary Disease & Critical Care Medicine

Additional Specialties: NMR based Metabolomics

ORCID logohttps://orcid.org/0000-0001-7105-0281


Top Author

Dr. Atul Rawat, PhD - Babasaheb Bhimrao Ambedkar University

Dr. Atul Rawat

PhD

Introduction

My research interest includes the exploratory application of NMR spectroscopy in early detection of Human Disease Biomarkers, Drug Metabolism and Toxicity, Cancer Metabolism, Immunology, and Neuroscience.

Primary Affiliation: Babasaheb Bhimrao Ambedkar University - Lucknow, Uttar Pradesh , India

Specialties:

Additional Specialties:

Research Interests:


View Dr. Atul Rawat’s Resume / CV

Education

Aug 2012 - Dec 2017
Babasaheb Bhimrao Ambedkar University
Ph.D.
Biotechnology
Aug 2010
Babasaheb Bhimrao Ambedkar University
M.Sc
Biotechnology
Sep 2008
Lucknow Christian Collge
B.Sc
Life Sciences

Publications

17Publications

186Reads

272Profile Views

49PubMed Central Citations

DuCLOX-2/5 Inhibition Attenuates Inflammatory Response and Induces Mitochondrial Apoptosis for Mammary Gland Chemoprevention.

Front Pharmacol 2018 6;9:314. Epub 2018 Apr 6.

Department of Pharmaceutical Sciences, School of Biosciences and Biotechnology, Babasaheb Bhimrao Ambedkar University (A Central University), Lucknow, India.

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http://dx.doi.org/10.3389/fphar.2018.00314DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5897656PMC
April 2018
21 Reads

Metabolomics approach discriminates toxicity index of pyrazinamide and its metabolic products, pyrazinoic acid and 5-hydroxy pyrazinoic acid.

Hum Exp Toxicol 2018 Apr 20;37(4):373-389. Epub 2017 Apr 20.

3 Department of Pharmaceutical Sciences, Babasaheb Bhimrao Ambedkar University, Vidya Vihar, Lucknow, Uttar Pradesh, India.

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http://dx.doi.org/10.1177/0960327117705426DOI Listing
April 2018
3 Reads
1 Citation
1.410 Impact Factor

-TSA-promoted syntheses of 5H-benzo[h] thiazolo[2,3-b]quinazoline and indeno[1,2-d] thiazolo[3,2-a]pyrimidine analogs: molecular modeling and in vitro antitumor activity against hepatocellular carcinoma.

Drug Des Devel Ther 2017 29;11:1623-1642. Epub 2017 May 29.

Department of Pharmaceutical Sciences, Babasaheb Bhimrao Ambedkar University, Vidya Vihar, Raebareli Road, Lucknow, Uttar Pradesh.

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http://dx.doi.org/10.2147/DDDT.S136692DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5459977PMC
April 2018
15 Reads
2 Citations
3.030 Impact Factor

GLA supplementation regulates PHD2 mediated hypoxia and mitochondrial apoptosis in DMBA induced mammary gland carcinoma.

Int J Biochem Cell Biol 2018 03 2;96:51-62. Epub 2018 Feb 2.

Department of Pharmaceutical Sciences, Babasaheb Bhimrao Ambedkar University (A Central University), Vidya Vihar, Raebareli Road, Lucknow, 226025 UP, India. Electronic address:

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http://dx.doi.org/10.1016/j.biocel.2018.01.011DOI Listing
March 2018
12 Reads
1 Citation
4.050 Impact Factor

Isolated mangiferin and naringenin exert antidiabetic effect via PPAR/GLUT4 dual agonistic action with strong metabolic regulation.

Chem Biol Interact 2018 Jan 6;280:33-44. Epub 2017 Dec 6.

Department of Pharmaceutical Sciences, Babasaheb Bhimrao Ambedkar University, Vidya Vihar, Raebareli Road, Lucknow 226025, Uttar Pradesh, India. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S00092797173099
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http://dx.doi.org/10.1016/j.cbi.2017.12.007DOI Listing
January 2018
13 Reads
1 Citation
2.580 Impact Factor

Serum Metabolic Disturbances Hailing in Initial Hours of Acute Myocardial Infarction Elucidated by NMR based Metabolomics

Rawat A, Srivastava RK, Dubey D, Guleria A, Singh S, Prakash A, Modi DR, Khetrapal CL, Tiwari S, Kumar D. Serum metabolic disturbances hailing in initial hours of acute myocardial infarction elucidated by NMR based metabolomics. Current Metabolomics. 2017 Apr 1;5(1):55-67.

Current Metabolomics

Background: Acute myocardial infarction (AMI) is a serious medical emergency and leading cause of cardiac-related deaths worldwide. The devastating outcome is sudden death of the patient within first few hours from the onset of symptoms. The rapid detection of physiological transformations associated with AMI coupled with instant treatment to reset these changes and monitoring response to treatment can greatly decrease the mortality and morbidity of patients. Objective: To establish the early hour metabolomic signatures in the sera of AMI patieints. Methodology: Metabolic profiles of sera collected from 42 AMI patients (immediately after the myocardial infarction) and 38 age/sex matched normal controls were obtained using high-resolution 1D 1H CPMG and diffusion edited NMR spectra. The metabolic profiles were compared using multivariate statistical analysis to identify the disease specific metabolic disturbances associated with AMI and, therefore, the perturbed biochemical pathways in this condition. Results: Our results revealed significant metabolic perturbations in AMI compared to control cohorts. The upregulated metabolites in AMI condition include arginine, glycine, tyrosine, phenylalanine, glucose, creatine, creatinine, lactate, N-acetyl glycoproteins and phospholipids, while the levels of amino acids (such as valine, alanine, glutamate, glutamine, threonine and methionine), citrate, acetone, choline, glycero-phosphocholine, trimethylamine-N-oxide and lipids/fatty acids were decreased. Receiver operating curve characteristics (ROC) confirmed the robustness and validity of these metabolic markers. Conclusion: The resulted metabolic profiling provided new insights into the metabolic processes involved in acute myocardial infarction. Further, we foresee that these changes would aid rapid clinical evaluation of myocardial infarction in emergency and its timely management.

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September 2017
34 Reads

6,7-dimethoxy-1,2,3,4-tetrahydro-isoquinoline-3-carboxylic acid attenuates heptatocellular carcinoma in rats with NMR-based metabolic perturbations.

Future Sci OA 2017 Aug 12;3(3):FSO202. Epub 2017 May 12.

Department of Pharmaceutical Sciences, Babasaheb Bhimrao Ambedkar University, Vidya Vihar, Raibareli Road, Lucknow 226025, India.

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http://dx.doi.org/10.4155/fsoa-2017-0008DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5583658PMC
August 2017
8 Reads
3 Citations

NMR-based urinary profiling of lactulose/mannitol ratio used to assess the altered intestinal permeability in acute on chronic liver failure (ACLF) patients.

Magn Reson Chem 2017 Apr 29;55(4):289-296. Epub 2016 Sep 29.

Department of Gastroenterology, Sanjay Gandhi Post Graduate Institute of Medical Science, Lucknow, India.

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http://doi.wiley.com/10.1002/mrc.4525
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http://dx.doi.org/10.1002/mrc.4525DOI Listing
April 2017
11 Reads
1 Citation
1.180 Impact Factor

H NMR-based serum metabolomics reveals erythromycin-induced liver toxicity in albino Wistar rats.

J Pharm Bioallied Sci 2016 Oct-Dec;8(4):327-334

Centre of Biomedical Research, Sanjay Gandhi Post Graduate Institute of Medical Sciences Campus, Lucknow, Uttar Pradesh, India.

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http://dx.doi.org/10.4103/0975-7406.199339DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5314833PMC
February 2017
26 Reads
2 Citations

Antiproliferative effect of isolated isoquinoline alkaloid from Mucuna pruriens seeds in hepatic carcinoma cells.

Nat Prod Res 2016 16;30(4):460-3. Epub 2015 Mar 16.

a Department of Pharmaceutical Sciences , Babasaheb Bhimrao Ambedkar University , Vidya Vihar, Raebareli Road, Lucknow 226025 , India.

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http://dx.doi.org/10.1080/14786419.2015.1020489DOI Listing
October 2016
7 Reads
3 Citations
0.920 Impact Factor

Isolated flavonoids from Ficus racemosa stem bark possess antidiabetic, hypolipidemic and protective effects in albino Wistar rats.

J Ethnopharmacol 2016 Apr 8;181:252-62. Epub 2016 Feb 8.

Department of Pharmaceutical Sciences, Babasaheb Bhimrao Ambedkar University, Vidya Vihar, Raebareli Road, Lucknow 226025, India. Electronic address:

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http://dx.doi.org/10.1016/j.jep.2016.02.004DOI Listing
April 2016
17 Reads
7 Citations
3.000 Impact Factor

NMR-Based Serum Metabolomics Discriminates Takayasu Arteritis from Healthy Individuals: A Proof-of-Principle Study.

J Proteome Res 2015 Aug 29;14(8):3372-81. Epub 2015 Jun 29.

†Centre of Biomedical Research and ‡Department of Immunology, SGPGIMS, Lucknow, 226014 Uttar Pradesh, India.

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http://dx.doi.org/10.1021/acs.jproteome.5b00422DOI Listing
August 2015
4 Reads
7 Citations
4.250 Impact Factor

Metabolite characterisation in peritoneal dialysis effluent using high-resolution (1) H and (1) H-(13) C NMR spectroscopy.

Magn Reson Chem 2014 Sep 10;52(9):475-9. Epub 2014 Jun 10.

Centre of Biomedical Research, Lucknow, Uttar Pradesh, India.

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http://dx.doi.org/10.1002/mrc.4094DOI Listing
September 2014
4 Reads
9 Citations
1.180 Impact Factor

NMR investigations of structural and dynamics features of natively unstructured drug peptide - salmon calcitonin: implication to rational design of potent sCT analogs.

J Pept Sci 2013 Jan 4;19(1):33-45. Epub 2012 Dec 4.

Centre of Biomedical Magnetic Resonance, Sanjay Gandhi Post-Graduate Institute of Medical Sciences Campus, Raibareli Road, Lucknow-, 226014, India.

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http://dx.doi.org/10.1002/psc.2471DOI Listing
January 2013
6 Reads
2 Citations
1.550 Impact Factor