Atsushi Hirao

Atsushi Hirao

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Atsushi Hirao

Publications by authors named "Atsushi Hirao"

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Identification of a novel arthritis-associated osteoclast precursor macrophage regulated by FoxM1.

Nat Immunol 2019 Dec 18;20(12):1631-1643. Epub 2019 Nov 18.

Department of Immunology and Cell Biology, Graduate School of Medicine and Frontier Biosciences, Osaka University, Osaka, Japan.

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http://dx.doi.org/10.1038/s41590-019-0526-7DOI Listing
December 2019

Identification of GSK3β inhibitor kenpaullone as a temozolomide enhancer against glioblastoma.

Sci Rep 2019 Jul 11;9(1):10049. Epub 2019 Jul 11.

Department of Neurosurgery, Faculty of Medicine, Institute of Medical, Pharmaceutical and Health Sciences, Kanazawa University, Kanazawa, Japan.

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http://dx.doi.org/10.1038/s41598-019-46454-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6624278PMC
July 2019

[Regulation of hematopoietic stem cell homeostasis by Spred1].

Rinsho Ketsueki 2018;59(11):2441-2448

Division of Molecular Genetics, Cancer and Stem Cell Research Program, Cancer Research Institute, Kanazawa University.

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http://dx.doi.org/10.11406/rinketsu.59.2441DOI Listing
May 2019

Autophagy inhibition synergizes with calcium mobilization to achieve efficient therapy of malignant gliomas.

Cancer Sci 2018 Aug 26;109(8):2497-2508. Epub 2018 Jul 26.

Cancer and Stem Cell Research Program, Division of Molecular Genetics, Cancer Research Institute, Kanazawa University, Kanazawa, Ishikawa, Japan.

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http://doi.wiley.com/10.1111/cas.13695
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http://dx.doi.org/10.1111/cas.13695DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6113445PMC
August 2018

JLP-JNK signaling protects cancer cells from reactive oxygen species-induced cell death.

Biochem Biophys Res Commun 2018 06;501(3):724-730

Division of Molecular Cell Signaling, Cancer Research Institute, Kanazawa University, Kanazawa, Japan. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S0006291X183110
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http://dx.doi.org/10.1016/j.bbrc.2018.05.055DOI Listing
June 2018

Spred1 Safeguards Hematopoietic Homeostasis against Diet-Induced Systemic Stress.

Cell Stem Cell 2018 05 26;22(5):713-725.e8. Epub 2018 Apr 26.

Division of Molecular Genetics, Cancer and Stem Cell Research Program, Cancer Research Institute, Kanazawa University, Kanazawa, Ishikawa 920-1192, Japan; WPI Nano Life Science Institute (WPI-Nano LSI), Kanazawa University, Kanazawa, Ishikawa 920-1192, Japan. Electronic address:

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http://dx.doi.org/10.1016/j.stem.2018.04.002DOI Listing
May 2018

Histochemical properties of bovine and ovine mammary glands during fetal development.

J Vet Med Sci 2018 Feb 15;80(2):263-271. Epub 2017 Dec 15.

Department of Animal Production Science, United Graduate School of Agricultural Science, Tokyo University of Agriculture and Technology, Tokyo 183-8509, Japan.

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http://dx.doi.org/10.1292/jvms.17-0584DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5836762PMC
February 2018

Distinct roles of Rheb and Raptor in activating mTOR complex 1 for the self-renewal of hematopoietic stem cells.

Biochem Biophys Res Commun 2018 01 22;495(1):1129-1135. Epub 2017 Nov 22.

Division of Molecular Genetics, Cancer and Stem Cell Research Program, Cancer Research Institute, Kanazawa University, Kakuma-machi, Kanazawa, Ishikawa 920-1192, Japan; WPI Nano Life Science Institute (WPI-Nano LSI), Kanazawa University, Kakuma-machi, Kanazawa, Ishikawa 920-1192, Japan. Electronic address:

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http://dx.doi.org/10.1016/j.bbrc.2017.11.140DOI Listing
January 2018

Regulation of Hematopoiesis and Hematological Disease by TGF-β Family Signaling Molecules.

Cold Spring Harb Perspect Biol 2017 Sep 1;9(9). Epub 2017 Sep 1.

Division of Molecular Genetics, Cancer Research Institute, Kanazawa University, Kanazawa, Ishikawa 920-1192, Japan.

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http://dx.doi.org/10.1101/cshperspect.a027987DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5585852PMC
September 2017

A novel splenic B1 regulatory cell subset suppresses allergic disease through phosphatidylinositol 3-kinase-Akt pathway activation.

J Allergy Clin Immunol 2016 10 2;138(4):1170-1182.e9. Epub 2016 Mar 2.

Department of Dermatology, Faculty of Medicine, University of Tsukuba, Tennodai, Tsukuba, Japan. Electronic address:

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http://dx.doi.org/10.1016/j.jaci.2015.12.1319DOI Listing
October 2016

Guest editorial: Cooperative networks for stem cell homeostasis in normal and malignant hematopoiesis: from metabolism to epigenetics.

Authors:
Atsushi Hirao

Int J Hematol 2016 Jun 19;103(6):605-6. Epub 2016 Apr 19.

Division of Molecular Genetics, Cancer Research Institute, Kanazawa University, Kanazawa, Ishikawa, 920-1192, Japan.

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http://dx.doi.org/10.1007/s12185-016-2012-4DOI Listing
June 2016

MIP-1α/CCL3-expressing basophil-lineage cells drive the leukemic hematopoiesis of chronic myeloid leukemia in mice.

Blood 2016 05 22;127(21):2607-17. Epub 2016 Mar 22.

Division of Molecular Bioregulation, Cancer Research Institute, Kanazawa University, Kanazawa, Ishikawa, Japan;

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http://dx.doi.org/10.1182/blood-2015-10-673087DOI Listing
May 2016

Foxo3a Inhibitors of Microbial Origin, JBIR-141 and JBIR-142.

Org Lett 2015 Nov 23;17(21):5476-9. Epub 2015 Oct 23.

National Institute of Advanced Industrial Science and Technology (AIST) , 2-4-7 Aomi, Koto-ku, Tokyo 135-0064, Japan.

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http://dx.doi.org/10.1021/acs.orglett.5b02842DOI Listing
November 2015

S6 Kinase- and β-TrCP2-Dependent Degradation of p19Arf Is Required for Cell Proliferation.

Mol Cell Biol 2015 Oct 3;35(20):3517-27. Epub 2015 Aug 3.

Division of Cell Proliferation, ART, Graduate School of Medicine, Tohoku University, Sendai, Japan

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http://dx.doi.org/10.1128/MCB.00343-15DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4573705PMC
October 2015

[Targeted molecular therapy based on advanced cancer stem cell model].

Authors:
Atsushi Hirao

Nihon Rinsho 2015 Aug;73(8):1256-62

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August 2015

[Roles of mTOR signalings in hematopoiesis and leukemogenesis].

Authors:
Atsushi Hirao

Rinsho Ketsueki 2015 Jun;56(6):601-5

Division of Molecular Genetics, Cancer Research Institute, Kanazawa University.

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http://dx.doi.org/10.11406/rinketsu.56.601DOI Listing
June 2015

[Regulation of cancer behavior mediated by mTOR signal].

Authors:
Atsushi Hirao

Nihon Rinsho 2015 May;73(5):773-8

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May 2015

[Roles of mTORC1 in acute myeloid leukemia].

Rinsho Ketsueki 2015 Apr;56(4):359-65

Division of Molecular Genetics, Cancer and Stem Cell Research Program, Cancer Research Institute, Kanazawa University.

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http://dx.doi.org/10.11406/rinketsu.56.359DOI Listing
April 2015

Strong therapeutic potential of γ-secretase inhibitor MRK003 for CD44-high and CD133-low glioblastoma initiating cells.

J Neurooncol 2015 Jan 8;121(2):239-50. Epub 2014 Oct 8.

Department of Neurosurgery, Division of Neuroscience, Graduate School of Medical Science, Kanazawa University, 13-1 Takara-machi, Kanazawa, Ishikawa, 920-8641, Japan.

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http://dx.doi.org/10.1007/s11060-014-1630-zDOI Listing
January 2015

Pleiotropic roles of mTOR complexes in haemato-lymphopoiesis and leukemogenesis.

J Biochem 2014 Aug 23;156(2):73-83. Epub 2014 Jun 23.

Division of Molecular Genetics, Cancer and Stem Cell Research Program, Cancer Research Institute, Kanazawa University, Kanazawa, Ishikawa 920-1192, Japan; and Department of Cell Signaling, Institute of Biomedical Science, Kansai Medical University, Hirakata, Osaka 570-8506, Japan

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http://dx.doi.org/10.1093/jb/mvu037DOI Listing
August 2014

Association of a murine leukaemia stem cell gene signature based on nucleostemin promoter activity with prognosis of acute myeloid leukaemia in patients.

Biochem Biophys Res Commun 2014 Jul 21;450(1):837-43. Epub 2014 Jun 21.

Division of Molecular Genetics, Cancer Research Institute, Kanazawa University, Kakuma-machi, Kanazawa, Ishikawa 920-1192, Japan. Electronic address:

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http://dx.doi.org/10.1016/j.bbrc.2014.06.066DOI Listing
July 2014

Loss of Tsc1 accelerates malignant gliomagenesis when combined with oncogenic signals.

J Biochem 2014 Apr 23;155(4):227-33. Epub 2013 Dec 23.

Division of Molecular Genetics, Cancer and Stem Cell Research Program, Cancer Research Institute, Kanazawa University, Kakuma-machi, Kanazawa, Ishikawa 920-1192, Japan.

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http://dx.doi.org/10.1093/jb/mvt112DOI Listing
April 2014

TRIB1 downregulates hepatic lipogenesis and glycogenesis via multiple molecular interactions.

J Mol Endocrinol 2014 Apr 24;52(2):145-58. Epub 2014 Feb 24.

Division of Human Genetics, Center for Molecular Medicine, Jichi Medical University, 3311-1 Yakushiji, Shimotsuke, Tochigi 329-0498, Japan Department of Anatomy Division of Integrative Physiology, Department of Physiology, Jichi Medical University, Tochigi 329-0498, Japan Health Care Food Research, Human Health Care Research, Research and Development, Kao Corporation, Sumida-ku, Tokyo 131-8501, Japan Jichi Medical University Health Care Center, Shimotsuke-shi, Tochigi 329-0498, Japan Division of Inflammation Research, Center for Molecular Medicine, Jichi Medical University, Tochigi 329-0498, Japan Division of Community and Family Medicine, Center for Community Medicine, Jichi Medical University, 3311-1 Yakushiji, Shimotsuke, Tochigi 329-0498, Japan.

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http://dx.doi.org/10.1530/JME-13-0243DOI Listing
April 2014

Crosstalk between the Rb pathway and AKT signaling forms a quiescence-senescence switch.

Cell Rep 2014 Apr 3;7(1):194-207. Epub 2014 Apr 3.

Division of Cancer Biology, The Cancer Institute, Japanese Foundation for Cancer Research, Koto-ku, Tokyo 135-8550, Japan; CREST, Japan Science Technology Agency, Saitama 332-0012, Japan. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2014.03.006DOI Listing
April 2014

TPO signal for stem cell genomic integrity.

Authors:
Atsushi Hirao

Blood 2014 Jan;123(4):459-60

KANAZAWA UNIVERSITY.

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http://dx.doi.org/10.1182/blood-2013-11-537084DOI Listing
January 2014

Metabolic regulation of osteoclast differentiation and function.

J Bone Miner Res 2013 Nov;28(11):2392-9

Department of Bone and Joint Disease, National Center for Geriatrics and Gerontology, Obu, Aichi, Japan.

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http://dx.doi.org/10.1002/jbmr.1976DOI Listing
November 2013

MIP-1α/CCL3-mediated maintenance of leukemia-initiating cells in the initiation process of chronic myeloid leukemia.

J Exp Med 2013 Nov 28;210(12):2661-73. Epub 2013 Oct 28.

Division of Molecular Bioregulation, 2 Exploratory Project on Cancer Stem Cells, and 3 Division of Molecular Genetics, Cancer Research Institute, Kanazawa University, Kanazawa 920-1192, Ishikawa, Japan.

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http://dx.doi.org/10.1084/jem.20130112DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3832924PMC
November 2013

Mechanistic / mammalian target protein of rapamycin signaling in hematopoietic stem cells and leukemia.

Cancer Sci 2013 Aug 9;104(8):977-82. Epub 2013 Jun 9.

Division of Molecular Genetics, Cancer and Stem Cell Research Program, Cancer Research Institute, Kanazawa University, Kanazawa, Japan.

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http://dx.doi.org/10.1111/cas.12189DOI Listing
August 2013

Abundant nucleostemin expression supports the undifferentiated properties of germ cell tumors.

Am J Pathol 2013 Aug;183(2):592-603

Division of Molecular Genetics, Cancer and Stem Cell Program, Cancer Research Institute, Kanazawa University, Kanazawa, Japan.

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http://dx.doi.org/10.1016/j.ajpath.2013.04.018DOI Listing
August 2013

B-cell linker protein expression contributes to controlling allergic and autoimmune diseases by mediating IL-10 production in regulatory B cells.

J Allergy Clin Immunol 2013 Jun 25;131(6):1674-82. Epub 2013 Mar 25.

Department of Dermatology, Faculty of Medicine, Institute of Medical, Pharmaceutical and Health Sciences, Kanazawa University, Kanazawa, Japan.

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http://dx.doi.org/10.1016/j.jaci.2013.01.044DOI Listing
June 2013

Ablation of Fbxw7 eliminates leukemia-initiating cells by preventing quiescence.

Cancer Cell 2013 Mar;23(3):347-61

Department of Molecular and Cellular Biology, Medical Institute of Bioregulation, Kyushu University, 3-1-1 Maidashi, Fukuoka, Fukuoka 812-8582, Japan.

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http://dx.doi.org/10.1016/j.ccr.2013.01.026DOI Listing
March 2013

Combination therapy using Notch and Akt inhibitors is effective for suppressing invasion but not proliferation in glioma cells.

Neurosci Lett 2013 Feb 20;534:316-21. Epub 2012 Dec 20.

Department of Neurosurgery, The First Bethune Clinical Hospital of Jilin University, 71 Xinmin Avenue, Changchun 130021, People's Republic of China.

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http://dx.doi.org/10.1016/j.neulet.2012.12.008DOI Listing
February 2013

Regulation of glycolysis by Pdk functions as a metabolic checkpoint for cell cycle quiescence in hematopoietic stem cells.

Cell Stem Cell 2013 Jan;12(1):49-61

Department of Cell Differentiation, The Sakaguchi Laboratory of Developmental Biology, Keio University School of Medicine, Shinano-machi, Shinjuku-ku, Tokyo, Japan.

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http://dx.doi.org/10.1016/j.stem.2012.10.011DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6592822PMC
January 2013

Nucleostemin in injury-induced liver regeneration.

Stem Cells Dev 2012 Nov 9;21(16):3044-54. Epub 2012 Jul 9.

Division of Molecular Genetics, Cancer Research Institute, Kanazawa University, Kanazawa, Japan.

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http://dx.doi.org/10.1089/scd.2011.0725DOI Listing
November 2012

[The PI3K-AKT-mTOR pathway as a target in cancer therapeutics].

Authors:
Atsushi Hirao

Nihon Rinsho 2012 Nov;70 Suppl 8:57-62

Division of Molecular Genetics, Cancer Research Institute, Kanazawa University.

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November 2012

[History and perspectives of leukemia stem cell research].

Authors:
Atsushi Hirao

Rinsho Ketsueki 2012 Oct;53(10):1814-8

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October 2012

mTORC1 is essential for leukemia propagation but not stem cell self-renewal.

J Clin Invest 2012 Jun 24;122(6):2114-29. Epub 2012 May 24.

Division of Molecular Genetics, Cancer and Stem Cell Research Program, Cancer Research Institute, Kanazawa University, Kanazawa, Japan.

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http://dx.doi.org/10.1172/JCI62279DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3366413PMC
June 2012

Cutting edge: mTORC1 in intestinal CD11c+ CD11b+ dendritic cells regulates intestinal homeostasis by promoting IL-10 production.

J Immunol 2012 May 13;188(10):4736-40. Epub 2012 Apr 13.

Department of Cell Signaling, Institute of Biomedical Science, Kansai Medical University, Moriguchi, Osaka 570-8506, Japan.

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http://dx.doi.org/10.4049/jimmunol.1200069DOI Listing
May 2012

Transient depletion of p53 followed by transduction of c-Myc and K-Ras converts ovarian stem-like cells into tumor-initiating cells.

Carcinogenesis 2011 Nov 8;32(11):1597-606. Epub 2011 Aug 8.

Division of Gene Regulation, Institute for Advanced Medical Research, School of Medicine, Keio University, 35 Shinanomachi, Shinjuku-ku, Tokyo 160-8582, Japan.

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https://academic.oup.com/carcin/article-lookup/doi/10.1093/c
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http://dx.doi.org/10.1093/carcin/bgr183DOI Listing
November 2011

Molecular pathology of tumor-initiating cells: lessons from Philadelphia chromosome-positive leukemia.

Pathol Int 2011 Sep 22;61(9):501-8. Epub 2011 Jun 22.

Division of Molecular Genetics, Cancer and Stem Cell Research Program, Cancer Research Institute, Kanazawa University, Kanazawa, Japan.

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http://dx.doi.org/10.1111/j.1440-1827.2011.02688.xDOI Listing
September 2011

[Development of novel therapies targeting leukemia stem cells].

Authors:
Atsushi Hirao

Rinsho Ketsueki 2011 Jul;52(7):484-9

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July 2011

Maintenance of genomic integrity in hematopoietic stem cells.

Int J Hematol 2011 Apr 9;93(4):434-439. Epub 2011 Mar 9.

Division of Molecular Genetics, Cancer and Stem Cell Research Program, Cancer Research Institute, Kanazawa University, Kakuma-machi, Kanazawa, Ishikawa, 920-1192, Japan.

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http://dx.doi.org/10.1007/s12185-011-0793-zDOI Listing
April 2011

The effect of pressure on the phase transition behavior of tridecane, pentadecane, and heptadecane: a Fourier transform infrared spectroscopy study.

J Chem Phys 2011 Apr;134(14):144503

College of Pharmaceutical Sciences, Ritsumeikan University, 1-1-1 Noji-higashi, Kusatsu, Shiga 525-8577, Japan.

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http://dx.doi.org/10.1063/1.3573376DOI Listing
April 2011

NKX2.2 suppresses self-renewal of glioma-initiating cells.

Cancer Res 2011 Feb 17;71(3):1135-45. Epub 2010 Dec 17.

Division of Molecular Genetics, Cancer and Stem Cell Research Program, Cancer Research Institute, Kanazawa University, Kanazawa, Ishikawa, Japan.

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http://dx.doi.org/10.1158/0008-5472.CAN-10-2304DOI Listing
February 2011

14-3-3sigma regulates B-cell homeostasis through stabilization of FOXO1.

Proc Natl Acad Sci U S A 2011 Jan 4;108(4):1555-60. Epub 2011 Jan 4.

Campbell Family Cancer Research Institute, Ontario Cancer Institute, University Health Network, Toronto, ON, Canada M5G 2C1.

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http://dx.doi.org/10.1073/pnas.1017729108DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3029705PMC
January 2011

Intrinsic cooperation between p16INK4a and p21Waf1/Cip1 in the onset of cellular senescence and tumor suppression in vivo.

Cancer Res 2010 Nov 9;70(22):9381-90. Epub 2010 Nov 9.

Divison of Cancer Biology, The Cancer Institute of Japanese Foundation for Cancer Research (JFCR), Tokyo, Japan.

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http://dx.doi.org/10.1158/0008-5472.CAN-10-0801DOI Listing
November 2010

Regulation of the HIF-1alpha level is essential for hematopoietic stem cells.

Cell Stem Cell 2010 Sep;7(3):391-402

Department of Cell Differentiation, The Sakaguchi Laboratory of Developmental Biology, Keio University School of Medicine, 35 Shinano-machi, Shinjuku-ku, Tokyo 160-8582, Japan.

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http://dx.doi.org/10.1016/j.stem.2010.06.020DOI Listing
September 2010

Novel therapeutic approach to eradicate tyrosine kinase inhibitor resistant chronic myeloid leukemia stem cells.

Cancer Sci 2010 Jul 5;101(7):1577-81. Epub 2010 Apr 5.

Division of Molecular Genetics, Center for Cancer and Stem Cell Research, Cancer Research Institute, Kanazawa University, Kanazawa, Japan.

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http://dx.doi.org/10.1111/j.1349-7006.2010.01584.xDOI Listing
July 2010

TGF-beta-FOXO signalling maintains leukaemia-initiating cells in chronic myeloid leukaemia.

Nature 2010 Feb;463(7281):676-80

Division of Molecular Genetics, Center for Cancer and Stem Cell Research, Cancer Research Institute, Kanazawa University, Kanazawa, Ishikawa 920-0934, Japan.

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http://dx.doi.org/10.1038/nature08734DOI Listing
February 2010

[Regulation of stem cell homeostasis by aging-related genes].

Authors:
Atsushi Hirao

Nihon Ronen Igakkai Zasshi 2009 Sep;46(5):402-4

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http://dx.doi.org/10.3143/geriatrics.46.402DOI Listing
September 2009

Distribution of the androgen receptor in the diencephalon and the pituitary gland in goats: Co-localisation with corticotrophin releasing hormone, arginine vasopressin and corticotrophs.

Vet J 2009 Aug 12;181(2):193-9. Epub 2008 May 12.

Department of Animal Science, Faculty of Agriculture, Utsunomiya University, 350 Minemachi, Utsunomiya-Shi 321-8505, Japan.

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http://dx.doi.org/10.1016/j.tvjl.2008.02.021DOI Listing
August 2009

[Recent advances in cancer stem cell research].

Authors:
Atsushi Hirao

Nihon Geka Gakkai Zasshi 2009 May;110(3):144-7

Division of Molecular Genetics, Center for Cancer and Stem Cell Research, Cancer Research Institute, Kanazawa University, Core Research for Evolutional Science and Technology (CREST), Japan Science and Technology Agency (JST).

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May 2009

The role of uropygial gland on sexual behavior in domestic chicken Gallus gallus domesticus.

Behav Processes 2009 Feb 1;80(2):115-20. Epub 2008 Nov 1.

Department of Animal Science, Faculty of Agriculture, Utsunomiya University, Mine-machi, Utsunomiya-shi, Japan.

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http://dx.doi.org/10.1016/j.beproc.2008.10.006DOI Listing
February 2009

Identification of stem cells during prepubertal spermatogenesis via monitoring of nucleostemin promoter activity.

Stem Cells 2008 Dec 18;26(12):3237-46. Epub 2008 Sep 18.

Division of Molecular Genetics, Center for Cancer and Stem Cell Research, Cancer Research Institute, Kanazawa University, Kanazawa, Ishikawa, Japan.

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http://dx.doi.org/10.1634/stemcells.2008-0506DOI Listing
December 2008

Regulation of reactive oxygen species and genomic stability in hematopoietic stem cells.

Antioxid Redox Signal 2008 Nov;10(11):1883-94

Division of Molecular Genetics, Center for Cancer and Stem Cell Research, Cancer Research Institute, Kanazawa University, Kanazawa, Ishikawa, Japan.

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http://dx.doi.org/10.1089/ars.2008.2114DOI Listing
November 2008

Stem cell defects in ATM-deficient undifferentiated spermatogonia through DNA damage-induced cell-cycle arrest.

Cell Stem Cell 2008 Feb;2(2):170-82

Department of Cell Differentiation, The Sakaguchi Laboratory of Developmental Biology, Keio University School of Medicine, 35 Shinano-machi, Shinjuku-ku, Tokyo 160-8582, Japan.

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http://dx.doi.org/10.1016/j.stem.2007.10.023DOI Listing
February 2008

Neural-specific ablation of the scaffold protein JSAP1 in mice causes neonatal death.

Neurosci Lett 2007 Dec 2;429(1):43-8. Epub 2007 Oct 2.

Division of Molecular Cell Signaling, Department of Molecular and Cellular Biology, Cancer Research Institute, Kanazawa University, Ishikawa 920-0934, Japan.

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http://dx.doi.org/10.1016/j.neulet.2007.09.057DOI Listing
December 2007

Regulation of the self-renewal ability of tissue stem cells by tumor-related genes.

Cancer Biomark 2007 ;3(4-5):193-201

Division of Molecular Genetics, Center for Cancer and Stem Cell Research, Cancer Research Institute, Kanazawa University, Kanazawa, Ishikawa, 920-0934, Japan.

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http://dx.doi.org/10.3233/cbm-2007-34-504DOI Listing
November 2007

Foxo3a is essential for maintenance of the hematopoietic stem cell pool.

Cell Stem Cell 2007 Jun;1(1):101-12

Department of Cell Differentiation, The Sakaguchi Laboratory of Developmental Biology, Keio University School of Medicine, Shinjuku-ku, Tokyo 160-8582, Japan.

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http://dx.doi.org/10.1016/j.stem.2007.02.001DOI Listing
June 2007

Cross-talk between Chk1 and Chk2 in double-mutant thymocytes.

Proc Natl Acad Sci U S A 2007 Mar 26;104(10):3805-10. Epub 2007 Feb 26.

Campbell Family Institute for Breast Cancer Research, 620 University Avenue, Suite 706, Toronto, Ontario, Canada M5G 2C1.

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http://dx.doi.org/10.1073/pnas.0611584104DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1820665PMC
March 2007

[Regulation of self-renewal of stem cells by aging-related genes].

Authors:
Atsushi Hirao

Nihon Ronen Igakkai Zasshi 2007 Mar;44(2):191-3

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http://dx.doi.org/10.3143/geriatrics.44.191DOI Listing
March 2007

Regulation of reactive oxygen species by Atm is essential for proper response to DNA double-strand breaks in lymphocytes.

J Immunol 2007 Jan;178(1):103-10

Department of Cell Differentiation, The Sakaguchi Laboratory of Developmental Biology, Keio University School of Medicine, Tokyo, Japan.

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http://dx.doi.org/10.4049/jimmunol.178.1.103DOI Listing
January 2007

Premeiotic germ cell defect in seminiferous tubules of Atm-null testis.

Biochem Biophys Res Commun 2006 Dec 3;351(4):993-8. Epub 2006 Nov 3.

Department of Cell Differentiation, The Sakaguchi Laboratory of Developmental Biology, Keio University School of Medicine, 35 Shinano-machi, Shinjuku-ku, Tokyo 160-8582, Japan.

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http://dx.doi.org/10.1016/j.bbrc.2006.10.145DOI Listing
December 2006

[Regulation of hematopoietic stem cell self-renewal by aging-related genes].

Authors:
Atsushi Hirao

Rinsho Ketsueki 2006 May;47(5):379-82

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May 2006

Reactive oxygen species act through p38 MAPK to limit the lifespan of hematopoietic stem cells.

Nat Med 2006 Apr 26;12(4):446-51. Epub 2006 Mar 26.

Department of Cell Differentiation, The Sakaguchi Laboratory of Developmental Biology, Keio University School of Medicine, 35 Shinano-machi, Shinjuku-ku, Tokyo 160-8582, Japan.

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http://dx.doi.org/10.1038/nm1388DOI Listing
April 2006

[Hematopoietic stem cell niche in bone marrow].

Seikagaku 2006 Apr;78(4):301-9

Department of Cell Differentiation, The Sakaguchi Laboratory of Developmental Biology, Keio University School of Medicine, 35 Shinano-machi, Shinjuku-ku, Tokyo 160-8582, Japan.

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April 2006

A quantitative matrigel assay for assessing repopulating capacity of prostate stem cells.

Biochem Biophys Res Commun 2005 Dec 21;338(2):1164-70. Epub 2005 Oct 21.

Department of Cell Differentiation, Keio University School of Medicine, Japan.

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http://dx.doi.org/10.1016/j.bbrc.2005.10.055DOI Listing
December 2005

Regulation of hematopoiesis and its interaction with stem cell niches.

Int J Hematol 2005 Dec;82(5):371-6

Department of Cell Differentiation, Sakaguchi Laboratory of Developmental Biology, School of Medicine, Keio University, Tokyo, Japan.

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http://dx.doi.org/10.1532/IJH97.05100DOI Listing
December 2005

Hematopoietic stem cells and their niche.

Trends Immunol 2005 Aug;26(8):426-33

Department of Cell Differentiation, The Sakaguchi Laboratory of Developmental Biology, School of Medicine, Keio University, 35 Shinano-machi, Shinjuku-ku, Tokyo 160-8582, Japan.

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http://dx.doi.org/10.1016/j.it.2005.06.006DOI Listing
August 2005

[Regulation of self-renewal of hematopoietic stem cells in the niche].

Tanpakushitsu Kakusan Koso 2005 Jun;50(7):886-91

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June 2005

Regulation of hematopoietic stem cells by the niche.

Trends Cardiovasc Med 2005 Feb;15(2):75-9

Department of Cell Differentiation, The Sakaguchi Laboratory of Developmental Biology, School of Medicine, Keio University, Tokyo 160-8582, Japan.

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http://dx.doi.org/10.1016/j.tcm.2005.03.002DOI Listing
February 2005

Regulation of cell cycle in hematopoietic stem cells by the niche.

Cell Cycle 2004 Dec 4;3(12):1481-3. Epub 2004 Dec 4.

Department of Cell Differentiation, The Sakaguchi Laboratory of Developmental Biology, School of Medicine, Keio University, Shinjuku-ku, Tokyo, Japan.

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http://dx.doi.org/10.4161/cc.3.12.1281DOI Listing
December 2004

Regulation of oxidative stress by ATM is required for self-renewal of haematopoietic stem cells.

Nature 2004 Oct;431(7011):997-1002

Department of Cell Differentiation, The Sakaguchi Laboratory of Developmental Biology, Keio University School of Medicine, 35 Shinano-machi, Shinjuku-ku, Tokyo 160-8582, Japan.

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http://dx.doi.org/10.1038/nature02989DOI Listing
October 2004

Tie2/angiopoietin-1 signaling regulates hematopoietic stem cell quiescence in the bone marrow niche.

Cell 2004 Jul;118(2):149-61

Department of Cell Differentiation, The Sakaguchi Laboratory of Developmental Biology, School of Medicine, Keio University, 35 Shinano-machi, Shinjuku-ku, Tokyo, 160-8582, Japan.

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http://dx.doi.org/10.1016/j.cell.2004.07.004DOI Listing
July 2004

Microtubule-associated [corrected] protein 7 increases the membrane expression of transient receptor potential vanilloid 4 (TRPV4).

J Biol Chem 2003 Dec 28;278(51):51448-53. Epub 2003 Sep 28.

Department of Pharmacology, Jichi Medical School 3311-1, Yakushiji, Minamikawachi, Tochigi, 329-0498, Japan.

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http://dx.doi.org/10.1074/jbc.M308212200DOI Listing
December 2003

Localization of mechanosensitive channel TRPV4 in mouse skin.

Neurosci Lett 2003 Dec;353(3):189-92

Department of Pharmacology, Jichi Medical School, Kawachi, Tochigi 329-0498, Japan.

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http://dx.doi.org/10.1016/j.neulet.2003.09.041DOI Listing
December 2003

Ataxia telangiectasia-mutated protein can regulate p53 and neuronal death independent of Chk2 in response to DNA damage.

J Biol Chem 2003 Sep 11;278(39):37782-9. Epub 2003 Jul 11.

Neuroscience Research Program of Ottawa Health Research Institute, University of Ottawa, Ottawa, Ontario K1H 8M5, Canada.

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http://www.jbc.org/lookup/doi/10.1074/jbc.M304049200
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http://dx.doi.org/10.1074/jbc.M304049200DOI Listing
September 2003

Chk2 regulates irradiation-induced, p53-mediated apoptosis in Drosophila.

Proc Natl Acad Sci U S A 2002 Aug 9;99(17):11305-10. Epub 2002 Aug 9.

Advanced Medical Discoveries Institute, Ontario Cancer Institute, University of Toronto, 620 University Avenue, Toronto, ON, Canada M5G 2C1.

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http://dx.doi.org/10.1073/pnas.172382899DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC123252PMC
August 2002

Chk2 is dispensable for p53-mediated G1 arrest but is required for a latent p53-mediated apoptotic response.

Proc Natl Acad Sci U S A 2002 Jul 3;99(15):9825-9. Epub 2002 Jul 3.

Cancer Biology Research Group and Department of Microbiology and Infectious Diseases, University of Calgary Health Sciences Center, Calgary, AL, Canada T2N 4N1.

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http://dx.doi.org/10.1073/pnas.152053599DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC125030PMC
July 2002