Publications by authors named "Astrid M Kral"

17Publications

Divergent kinetics differentiate the mechanism of action of two HDAC inhibitors.

Biochemistry 2014 Feb 22;53(4):725-34. Epub 2014 Jan 22.

Merck & Co., Inc. , 33 Avenue Louis Pasteur, Boston, Massachusetts 02115, United States.

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http://pubs.acs.org/doi/10.1021/bi400936h
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http://dx.doi.org/10.1021/bi400936hDOI Listing
February 2014

Rapid assembly of diverse and potent allosteric Akt inhibitors.

Bioorg Med Chem Lett 2008 Mar 17;18(6):2211-4. Epub 2007 Oct 17.

Department of Medicinal Chemistry, Merck Research Laboratories, Merck & Co., PO Box 4, West Point, PA 19486, USA.

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http://dx.doi.org/10.1016/j.bmcl.2007.10.023DOI Listing
March 2008

Optimization of 2,3,5-trisubstituted pyridine derivatives as potent allosteric Akt1 and Akt2 inhibitors.

Bioorg Med Chem Lett 2008 Mar 23;18(6):2194-7. Epub 2007 Dec 23.

Department of Medicinal Chemistry, Merck Research Laboratories, Merck & Co., PO Box 4, West Point, PA 19486, USA.

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http://linkinghub.elsevier.com/retrieve/pii/S0960894X0701496
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http://dx.doi.org/10.1016/j.bmcl.2007.12.040DOI Listing
March 2008

Development of pyridopyrimidines as potent Akt1/2 inhibitors.

Bioorg Med Chem Lett 2008 Feb 19;18(4):1274-9. Epub 2008 Jan 19.

Department of Medicinal Chemistry, Merck Research Laboratories, Merck & Co., PO Box 4, West Point, PA 19486, USA.

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http://dx.doi.org/10.1016/j.bmcl.2008.01.054DOI Listing
February 2008

Optimization of biaryl Selective HDAC1&2 Inhibitors (SHI-1:2).

Bioorg Med Chem Lett 2008 Jan 19;18(2):726-31. Epub 2007 Nov 19.

Department of Drug Design and Optimization-Medicinal Chemistry, Merck Research Laboratories, 33 Avenue Louis Pasteur, Boston, MA 02115, USA.

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http://dx.doi.org/10.1016/j.bmcl.2007.11.047DOI Listing
January 2008

Amino acid derivatives as histone deacetylase inhibitors.

Bioorg Med Chem Lett 2008 Jan 13;18(1):34-8. Epub 2007 Nov 13.

Department of Drug Design and Optimization-Medicinal Chemistry, Merck Research Laboratories, 33 Avenue Louis Pasteur, Boston, MA 02115, USA.

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http://dx.doi.org/10.1016/j.bmcl.2007.11.017DOI Listing
January 2008

Design of novel histone deacetylase inhibitors.

Bioorg Med Chem Lett 2007 Aug 27;17(16):4619-24. Epub 2007 May 27.

Department of Drug Design & Optimization, Merck Research Laboratories, 33 Avenue Louis Pasteur, Boston, MA 02115, USA.

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http://dx.doi.org/10.1016/j.bmcl.2007.05.080DOI Listing
August 2007